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Journal articles on the topic 'Adenosine triphosphatase genes Expression'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Dvorak, Pavel, Martin Pesta, and Pavel Soucek. "ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer." Tumor Biology 39, no. 5 (2017): 101042831769980. http://dx.doi.org/10.1177/1010428317699800.

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Adenosine triphosphate–binding cassette proteins constitute a large family of active transporters through extracellular and intracellular membranes. Increased drug efflux based on adenosine triphosphate–binding cassette protein activity is related to the development of cancer cell chemoresistance. Several articles have focused on adenosine triphosphate–binding cassette gene expression profiles (signatures), based on the expression of all 49 human adenosine triphosphate–binding cassette genes, in individual tumor types and reported connections to established clinicopathological features. The ai

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2

Ojamaa, K., A. M. Samarel, J. M. Kupfer, C. Hong, and I. Klein. "Thyroid hormone effects on cardiac gene expression independent of cardiac growth and protein synthesis." American Journal of Physiology-Endocrinology and Metabolism 263, no. 3 (1992): E534—E540. http://dx.doi.org/10.1152/ajpendo.1992.263.3.e534.

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Prior studies have demonstrated the importance of hemodynamic loading in mediating thyroxine (T4)-induced cardiac hypertrophy. Direct cellular effects of thyroid hormone have been implicated in modulating the expression of the myosin heavy chain (MHC) genes and the slow sarcoplasmic reticulum calcium adenosine triphosphatase (SR Ca(2+)-ATPase) gene. In the present report, administration of T4 for 72 h did not stimulate growth of the hemodynamically unloaded heterotopic isograft. The synthetic rates of total cardiac proteins and MHC in the isograft remained significantly lower at 64 and 53% of

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Habib, Tania, Heon Park, Mark Tsang, et al. "Myc stimulates B lymphocyte differentiation and amplifies calcium signaling." Journal of Cell Biology 179, no. 4 (2007): 717–31. http://dx.doi.org/10.1083/jcb.200704173.

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Deregulated expression of the Myc family of transcription factors (c-, N-, and L-myc) contributes to the development of many cancers by a mechanism believed to involve the stimulation of cell proliferation and inhibition of differentiation. However, using B cell–specific c-/N-myc double-knockout mice and Eμ-myc transgenic mice bred onto genetic backgrounds (recombinase-activating gene 2−/− and Btk−/− Tec−/−) whereby B cell development is arrested, we show that Myc is necessary to stimulate both proliferation and differentiation in primary B cells. Moreover, Myc expression results in sustained

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Davis, Lowell, James Musso, Divya Soman, Samantha Louey, Jonathan W. Nelson, and Sonnet S. Jonker. "Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 3 (2018): R500—R508. http://dx.doi.org/10.1152/ajpregu.00319.2017.

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Fetal anemia causes rapid and profound changes in cardiac structure and function, stimulating proliferation of the cardiac myocytes, expansion of the coronary vascular tree, and impairing early contraction and relaxation. Although hypoxia-inducible factor-1α is sure to play a role, adenosine, a metabolic byproduct that increases coronary flow and growth, is implicated as a major stimulus for these adaptations. We hypothesized that genes involved in myocardial adenosine signaling would be upregulated in chronically anemic fetuses and that calcium-handling genes would be downregulated. After ste

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Aubier, M., and N. Viires. "Calcium ATPase and respiratory muscle function." European Respiratory Journal 11, no. 3 (1998): 758–66. http://dx.doi.org/10.1183/09031936.98.11030758.

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The sarcoplasmic reticulum (SR) of striated muscle is a highly specialized intracellular membrane system that plays a key role in the contraction-relaxation cycle of muscle. Its primary function is the regulation of cytoplasmic Ca2+ concentration. A key element in this regulation is the Sarco(endo)plasmic reticulum Ca2+-adenosine triphosphatase (SERCA), which by sequestering Ca2+ into the SR, induces and maintains relaxation. It has been extensively studied with respect to structure and mechanism of action, and more recently to gene expression. Three separate genes encode five SERCA isoforms,

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Li, Jiajia, Xionghui Li, Hong Huang, et al. "Role of SERCA3 in the Prognosis and Immune Function in Pan-Cancer." Journal of Oncology 2022 (November 4, 2022): 1–12. http://dx.doi.org/10.1155/2022/9359879.

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The sarcoendoplasmic reticulum calcium adenosine triphosphatase (ATPase) 3 (SERCA3), a member of the SERCA protein family, is located at the endoplasmic reticulum. Its main function is to pump Ca2+ into the endoplasmic reticulum and is involved in maintaining intracellular calcium homeostasis and signal transduction, which are very important factors impacting cancer development and progression. However, the specific role of SERCA3 in cancer remains unclear. Our study, for the first time, comprehensively analyzed the SERCA3 expression profile in multiple cancers and its prognostic value in diff

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Nemtsova, M. V., and I. V. Bure. "Targeting of the SWI/SNF chromatin remodeling complex in cancer therapy." Advances in Molecular Oncology 10, no. 1 (2023): 8–17. http://dx.doi.org/10.17650/2313-805x-2023-10-1-8-17.

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Chromatin remodeling is the one of the main epigenetic ways of gene expression regulation both in normal cells and in oncological diseases. Genes encoding protein subunits of SWI/ SNF remodeling complexes often mutate and/or change their expression in human tumors, affecting the expression programs of many genes during carcinogenesis, which is associated with the occurrence and progression of cancer. Today, there are no therapeutic drugs that could directly change the structure of chromatin because of complexity of this process with involvement of a large number of genes, proteins, non-coding

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Mahajan, Milind C., та Sherman M. Weissman. "DNA-dependent adenosine triphosphatase (helicaselike transcription factor) activates β-globin transcription in K562 cells". Blood 99, № 1 (2002): 348–56. http://dx.doi.org/10.1182/blood.v99.1.348.

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Correct developmental regulation of β-like globin gene expression is achieved by preferential transcription of a gene at a given developmental stage, silencing of other β-like gene promoters, and competition among these promoters for interaction with the locus control region (LCR). Several evolutionarily conserved DNA elements in the promoters of the β-like genes and LCR have been studied in detail, and the role of their binding factors has been investigated. However, the β-globin promoter includes additional evolutionarily conserved sequences of unknown function. The present study examined th

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Varchenko, O., M. Kuchuk, M. Parii, and Y. Symonenko. "Matching of the GFP Gene Expression Levels by Different Terminator Sequences Regulation." Mikrobiolohichnyi Zhurnal 82, no. 6 (2020): 74–83. http://dx.doi.org/10.15407/microbiolj82.06.074.

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The ability to express foreign genes in plant cells provides a powerful tool for studying the function of specific genes. In addition, the creation of genetically modified plants may provide new important features that are useful for industrial production or pharmaceutical applications. One of the key parameters for the development of a high level of heterologous genes expression is the efficiency of terminators used in genetic engineering, since the level of gene expression depends on its choice. Aim. Study of the gfp gene expression regulation in Nicotiana rustica L. tissues by different ter

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10

Singer, Thomas D., Koreen M. Clements, Jeffrey W. Semple, et al. "Seawater tolerance and gene expression in two strains of Atlantic salmon smolts." Canadian Journal of Fisheries and Aquatic Sciences 59, no. 1 (2002): 125–35. http://dx.doi.org/10.1139/f01-205.

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The seawater tolerance of Atlantic salmon (Salmo salar) smolts reared under identical hatchery conditions was assessed in two Norwegian strains: AquaGen and Imsa. Plasma ion levels were disrupted in both strains following seawater exposure, but these disruptions were more profound in the AquaGen fish. To investigate the mechanisms underlying these differences, we measured gill Na+,K+-adenosine triphosphatase (ATPase) activity and mRNA levels of Na+,K+-ATPase α-subunit and two isoforms of the cystic fibrosis transmembrane conductance regulator (CFTR). Gill Na+,K+-ATPase activity rose significan

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Chowdhury, Aniqua Tasnim, Md Nazmul Hasan, Fahmid H. Bhuiyan, et al. "Identification, characterization of Apyrase (APY) gene family in rice (Oryza sativa) and analysis of the expression pattern under various stress conditions." PLOS ONE 18, no. 5 (2023): e0273592. http://dx.doi.org/10.1371/journal.pone.0273592.

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Apyrase (APY) is a nucleoside triphosphate (NTP) diphosphohydrolase (NTPDase) which is a member of the superfamily of guanosine diphosphatase 1 (GDA1)—cluster of differentiation 39 (CD39) nucleoside phosphatase. Under various circumstances like stress, cell growth, the extracellular adenosine triphosphate (eATP) level increases, causing a detrimental influence on cells such as cell growth retardation, ROS production, NO burst, and apoptosis. Apyrase hydrolyses eATP accumulated in the extracellular membrane during stress, wounds, into adenosine diphosphate (ADP) and adenosine monophosphate (AMP

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Lew, Sze Yuen, Nur Shahirah Mohd Hisam, Michael Weng Lok Phang, et al. "Adenosine Improves Mitochondrial Function and Biogenesis in Friedreich’s Ataxia Fibroblasts Following L-Buthionine Sulfoximine-Induced Oxidative Stress." Biology 12, no. 4 (2023): 559. http://dx.doi.org/10.3390/biology12040559.

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Adenosine is a nucleoside that is widely distributed in the central nervous system and acts as a central excitatory and inhibitory neurotransmitter in the brain. The protective role of adenosine in different pathological conditions and neurodegenerative diseases is mainly mediated by adenosine receptors. However, its potential role in mitigating the deleterious effects of oxidative stress in Friedreich’s ataxia (FRDA) remains poorly understood. We aimed to investigate the protective effects of adenosine against mitochondrial dysfunction and impaired mitochondrial biogenesis in L-buthionine sul

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13

Liu, Hong, Zhigang Wang, Weihui Xu, et al. "Bacillus pumilus LZP02 Promotes Rice Root Growth by Improving Carbohydrate Metabolism and Phenylpropanoid Biosynthesis." Molecular Plant-Microbe Interactions® 33, no. 10 (2020): 1222–31. http://dx.doi.org/10.1094/mpmi-04-20-0106-r.

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Elucidation of the underlying mechanisms of plant growth promotion of rhizobacteria is very important. This study explored the mechanism by which Bacillus pumilus LZP02 promotes growth in rice roots through proteomic, transcriptomic, and metabolomic techniques. The results showed that B. pumilus LZP02 promoted the absorption of phosphorous, calcium, and magnesium ions by colonization of rice roots and enhanced peroxidase, catalase, superoxide dismutase, and Ca2+Mg2+ adenosine triphosphatase activities and chlorophyll contents in rice. The proteomic results showed that most of the differentiall

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Mierzejewska, Paulina, Noemi Di Marzo, Magdalena A. Zabielska-Kaczorowska, et al. "Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a Mouse." Pharmaceuticals 16, no. 10 (2023): 1409. http://dx.doi.org/10.3390/ph16101409.

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The vascular endothelium is key target for immune and thrombotic responses that has to be controlled in successful xenotransplantation. Several genes were identified that, if induced or overexpressed, help to regulate the inflammatory response and preserve the transplanted organ function and metabolism. However, few studies addressed combined expression of such genes. The aim of this work was to evaluate in vivo the effects of the simultaneous expression of three human genes in a mouse generated using the multi-cistronic F2A technology. Male 3-month-old mice that express human heme oxygenase 1

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15

Sadeghi Fazel, Farida, Amir Rashid Lamir, Rambod Khajeie, and Akbar Safipour Afshar. "The Effect of Combined Training on ABCG5 and ABCG8 in Coronary Artery Bypass Graft Patients." Quarterly of Horizon of Medical Sciences 28, no. 3 (2022): 398–411. http://dx.doi.org/10.32598/hms.28.3.3775.1.

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Aims Coronary heart disease is one of the leading causes of mortality in modern societies. The disease is associated with the lack of physical activity and the expression of some genes involved in blood cholesterol transportation. Adenosine triphosphate (ATP)-binding cassette transporters G5/G8) ABCG5 and ABCG8) is the expression of adenosine triphosphate-dependent box protein genes 5 and 8, a member of the ABC transporter family, playing a crucial role in high-density lipoprotein cholesterol and lipoproteins metabolism. The action of ABCG5/8 is to remove cholesterol and decrease its toxicity.

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Zhang, Ziling, Tao Tong, Yunxia Fang, et al. "Genome-Wide Identification of Barley ABC Genes and Their Expression in Response to Abiotic Stress Treatment." Plants 9, no. 10 (2020): 1281. http://dx.doi.org/10.3390/plants9101281.

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Adenosine triphosphate-binding cassette transporters (ABC transporters) participate in various plant growth and abiotic stress responses. In the present study, 131 ABC genes in barley were systematically identified using bioinformatics. Based on the classification method of the family in rice, these members were classified into eight subfamilies (ABCA–ABCG, ABCI). The conserved domain, amino acid composition, physicochemical properties, chromosome distribution, and tissue expression of these genes were predicted and analyzed. The results showed that the characteristic motifs of the barley ABC

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Wu, Patricia S. C., Anselmo S. Moriscot, Kirk U. Knowlton, Randa Hilal-Dandan, Huaping He та Wolfgang H. Dillmann. "α1-Adrenergic Stimulation Inhibits 3,5,3′-Triiodothyronine-Induced Expression of the Rat Heart Sarcoplasmic Reticulum Ca2+Adenosine Triphosphatase Gene1". Endocrinology 138, № 1 (1997): 114–20. http://dx.doi.org/10.1210/endo.138.1.4893.

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18

Robin, Elodie, Fabrice Marcillac, and Eric Raddatz. "A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 7 (2015): R614—R626. http://dx.doi.org/10.1152/ajpregu.00423.2014.

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To what extent hypoxia alters the adenosine (ADO) system and impacts on cardiac function during embryogenesis is not known. Ectonucleoside triphosphate diphosphohydrolase (CD39), ecto-5′-nucleotidase (CD73), adenosine kinase (AdK), adenosine deaminase (ADA), equilibrative (ENT1,3,4), and concentrative (CNT3) transporters and ADO receptors A1, A2A, A2B, and A3 constitute the adenosinergic system. During the first 4 days of development chick embryos were exposed in ovo to normoxia followed or not followed by 6 h hypoxia. ADO and glycogen content and mRNA expression of the genes were determined i

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Song, Jie, Hong-Man Hou, Hong-Yan Wu, et al. "Transcriptomic Analysis of Vibrio parahaemolyticus Reveals Different Virulence Gene Expression in Response to Benzyl Isothiocyanate." Molecules 24, no. 4 (2019): 761. http://dx.doi.org/10.3390/molecules24040761.

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Vibrio parahaemolyticus isolated from seafood is a pathogenic microorganism that leads to several acute diseases that are harmful to our health and is frequently transmitted by food. Therefore, there is an urgent need for the control and suppression of this pathogen. In this paper, transcriptional analysis was used to determine the effect of treatment with benzyl isothiocyanate (BITC) extracted from cruciferous vegetables on V. parahaemolyticus and to elucidate the molecular mechanisms underlying the response to BITC. Treatment with BITC resulted in 332 differentially expressed genes, among wh

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20

Guo, Zhenhua, Lei Lv, Di Liu, et al. "Network Meta-Analysis: Effect of Cold Stress on the Gene Expression of Swine Adipocytes ATGL, CIDEA, UCP2, and UCP3." Current Issues in Molecular Biology 46, no. 5 (2024): 3866–76. http://dx.doi.org/10.3390/cimb46050240.

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Cold stress significantly affects gene expression in adipocytes; studying this phenomenon can help reveal the pathogeneses of conditions such as obesity and insulin resistance. Adipocyte triglyceride lipase (ATGL); cell death-inducing deoxyribonucleic acid (DNA) fragmentation factor subunit alpha (DFFA)-like effector (CIDEA); and uncoupling protein genes UCP1, UCP2, and UCP3 are the most studied genes in pig adipose tissues under cold stress. However, contradictory results have been observed in gene expression changes to UCP3 and UCP2 when adipose tissues under cold stress were examined. There

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Gilmore-Hebert, M., J. W. Schneider, A. L. Greene, et al. "Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells." Journal of Clinical Investigation 84, no. 1 (1989): 347–51. http://dx.doi.org/10.1172/jci114161.

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22

Balakrishnan, Kumudha, Christine M. Stellrecht, Davide Genini, et al. "Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP." Blood 105, no. 11 (2005): 4455–62. http://dx.doi.org/10.1182/blood-2004-05-1699.

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Abstract Myeloid cell leukemia-1 (MCL-1) acts as a key survival factor for chronic lymphocytic leukemia (CLL) cells. In addition, dissipation of cellular bioenergy may impose a lethal effect on these quiescent cells. Previously, in multiple myeloma cell lines we demonstrated that halogenated adenosine (8-Cl-Ado) was phosphorylated to triphosphate (8-Cl–adenosine triphosphate [ATP]), which preferentially incorporated into mRNA and inhibited RNA synthesis by premature transcription termination. Furthermore, 8-Cl-ATP accumulation was associated with a decline in cellular bioenergy. Based on these

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Jones, Richard E., Anja V. Gruszczyk, Christina Schmidt, et al. "Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease." Nature Cardiovascular Research 2, no. 8 (2023): 733–45. http://dx.doi.org/10.1038/s44161-023-00312-z.

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AbstractRecurrent myocardial ischemia can lead to left ventricular (LV) dysfunction in patients with coronary artery disease (CAD). In this observational cohort study, we assessed for chronic metabolomic and transcriptomic adaptations within LV myocardium of patients undergoing coronary artery bypass grafting. During surgery, paired transmural LV biopsies were acquired on the beating heart from regions with and without evidence of inducible ischemia on preoperative stress perfusion cardiovascular magnetic resonance. From 33 patients, 63 biopsies were acquired, compared to analysis of LV sample

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Ghaffari Novin, M., Azra Allahveisi, M. Noruzinia, et al. "The Relationship Between Transcript Expression Levels of Nuclear Encoded (TFAM, NRF1) and Mitochondrial Encoded (MT-CO1) Genes in Single Human Oocytes During Oocyte Maturation." Balkan Journal of Medical Genetics 18, no. 1 (2015): 39–46. http://dx.doi.org/10.1515/bjmg-2015-0004.

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Abstract In some cases of infertility in women, human oocytes fail to mature when they reach the metaphase II (MII) stage. Mitochondria plays an important role in oocyte maturation. A large number of mitochondrial DNA (mtDNA), copied in oocytes, is essential for providing adenosine triphosphate (ATP) during oocyte maturation. The purpose of this study was to identify the relationship between transcript expression levels of the mitochondrial encoded gene (MT-CO1) and two nuclear encoded genes, nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) in various stages

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Takeuchi, Hiroya, Nancy C. Greep, Dave S. B. Hoon, et al. "Hypermethylation of Adenosine Triphosphate-Binding Cassette Transporter Genes in Primary Hyperparathyroidism and Its Effect on Sestamibi Imaging." Journal of Clinical Endocrinology & Metabolism 92, no. 5 (2007): 1785–90. http://dx.doi.org/10.1210/jc.2006-2010.

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Abstract Context: Retention of technetium-99m-sestamibi (99mTc-sestamibi) by parathyroid adenomas appears to be due to the loss of at least one membrane transporter, multidrug resistance 1 (MDR1), and possibly another, multidrug resistance-associated protein 1 (MRP1). Objective: The objective was to determine whether hypermethylation of either gene plays a role in their expression and 99mTc-sestamibi retention. Design: This was a retrospective study on a convenience sample of paraffin-embedded parathyroid glands. Setting: The study was performed at the John Wayne Cancer Institute at Saint John

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Reshetnikov, Alexander, Natalia Solntseva, Olga Rozova, Ildar Mustakhimov, Yuri Trotsenko, and Valentina Khmelenina. "ATP- and Polyphosphate-Dependent Glucokinases from Aerobic Methanotrophs." Microorganisms 7, no. 2 (2019): 52. http://dx.doi.org/10.3390/microorganisms7020052.

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The genes encoding adenosine triphosphate (ATP)- and polyphosphate (polyP)-dependent glucokinases (Glk) were identified in the aerobic obligate methanotroph Methylomonas sp. 12. The recombinant proteins were obtained by the heterologous expression of the glk genes in Esherichia coli. ATP-Glk behaved as a multimeric protein consisting of di-, tri-, tetra-, penta- and hexamers with a subunit molecular mass of 35.5 kDa. ATP-Glk phosphorylated glucose and glucosamine using ATP (100% activity), uridine triphosphate (UTP) (85%) or guanosine triphosphate (GTP) (71%) as a phosphoryl donor and exhibite

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Kotani, Kohei, Joji Kawabe, Hiroyasu Morikawa, Tomohiko Akahoshi, Makoto Hashizume, and Susumu Shiomi. "Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension." Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/349215.

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The functions of genes involved in idiopathic portal hypertension (IPH) remain unidentified. The present study was undertaken to identify the functions of genes expressed in blood samples from patients with IPH through comprehensive analysis of gene expression using DNA microarrays. The data were compared with data from healthy individuals to explore the functions of genes showing increased or decreased expression in patients with IPH. In cluster analysis, no dominant probe group was shown to differ between patients with IPH and healthy controls. In functional annotation analysis using the Dat

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Waugh, Declan Timothy. "Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health." International Journal of Environmental Research and Public Health 16, no. 8 (2019): 1427. http://dx.doi.org/10.3390/ijerph16081427.

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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neur

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Chutani, Namita, Sandhya Ragula, Khajamohiddin Syed, and Suresh B. Pakala. "Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer." Biomolecules 13, no. 10 (2023): 1527. http://dx.doi.org/10.3390/biom13101527.

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A newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain. MORC2 is highly expressed in a variety of human cancers. It controls diverse signaling pathways essential for cancer development through its target genes and interacting partners. MORC2 promotes cancer cells’ growth, invasion, and migration by regulating the expression of genes involved in these processes. MORC2 is localized primarily in the nucleus and is also found in the cytoplasm. In the

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Zaza, Gianluigi, Meyling Cheok, Wenjian Yang, et al. "Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment." Blood 106, no. 5 (2005): 1778–85. http://dx.doi.org/10.1182/blood-2005-01-0143.

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Abstract To elucidate interpatient variability in thioguanine nucleotide (TGN) concentrations in acute lymphoblastic leukemia (ALL) cells, we determined the TGN concentrations in leukemic blasts from 82 children with newly diagnosed ALL after intravenous administration of mercaptopurine (MP). Patients treated with MP alone achieved higher TGN concentrations than those treated with the combination of methotrexate plus mercaptopurine (MTX + MP). Analysis of the expression of approximately 9600 genes in ALL cells obtained at diagnosis identified 60 gene probes significantly associated with TGN ac

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Hayakawa, Yoichi. "Comments to Recent Studies Showing Systemic Mechanisms Enabling Drosophila Larvae to Recover From Stress-Induced Damages." International Journal of Insect Science 10 (January 2018): 117954331879589. http://dx.doi.org/10.1177/1179543318795894.

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Compensational recovery from the damage created by stressors is important for all animals. However, how organisms recover from stress-induced negative impacts has been poorly understood. An 1-hour exposure to heat stress at 35°C led to reduced feeding activity of Drosophila melanogaster larvae, which caused reduction in body weight 2 hours after the stress, but not at other times. Such weight losses seem to be rescued by following enhanced feeding activities. We investigated the mechanisms underlying the accelerated feeding activity after the stress-induced reduction in feeding behavior. Our d

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Zhu, Ruojia, Xiaoxia Dong, Yingying Xue, et al. "Redox-Responsive Transcription Factor 1 (RRFT1) Is Involved in Extracellular ATP-Regulated Arabidopsis thaliana Seedling Growth." Plant and Cell Physiology 61, no. 4 (2020): 685–98. http://dx.doi.org/10.1093/pcp/pcaa014.

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Abstract Extracellular adenosine triphosphate (eATP) is an apoplastic signaling molecule that plays an essential role in the growth and development of plants. Arabidopsis seedlings have been reported to respond to eATP; however, the downstream signaling components are still not well understood. In this study, we report that an ethylene-responsive factor, Redox-Responsive Transcription Factor 1 (RRTF1), is involved in eATP-regulated Arabidopsis thaliana seedling growth. Exogenous adenosine triphosphate inhibited green seedling root growth and induced hypocotyl bending of etiolated seedlings. RR

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Słowińska, Mariola, Łukasz Paukszto, Laura Pardyak, et al. "Transcriptome and Proteome Analysis Revealed Key Pathways Regulating Final Stage of Oocyte Maturation of the Turkey (Meleagris gallopavo)." International Journal of Molecular Sciences 22, no. 19 (2021): 10589. http://dx.doi.org/10.3390/ijms221910589.

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In birds, the zona pellucida (ZP) matrix that surrounds the ovulated oocyte—called the inner perivitelline layer—is involved in sperm–zona interaction and successful fertilization. To identify the important genes and proteins connected with the final step of egg development, next-generation sequencing and two-dimensional electrophoresis, combined with mass spectrometry, were used for the analysis of mature oocytes at the F1 developmental stage. A total of 8161 genes and 228 proteins were annotated. Six subfamilies of genes, with codes ZP, ZP1–4, ZPD, and ZPAX, were identified, with the dominan

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Liu, Min, Xue-Ying Zhang, Chen-Zhu Wang, and De-Hua Wang. "Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)." International Journal of Molecular Sciences 24, no. 1 (2022): 342. http://dx.doi.org/10.3390/ijms24010342.

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Skeletal muscle-based nonshivering thermogenesis (NST) plays an important role in the regulation and maintenance of body temperature in birds and large mammals, which do not contain brown adipose tissue (BAT). However, the relative contribution of muscle-based NST to thermoregulation is not clearly elucidated in wild small mammals, which have evolved an obligate thermogenic organ of BAT. In this study, we investigated whether muscle would become an important site of NST when BAT function is conditionally minimized in Brandt’s voles (Lasiopodomys brandtii). We surgically removed interscapular B

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LIU, Z., Y. LI, J. WANG, X. HE, and C. TIAN. "Different respiration metabolism between mycorrhizal and non-mycorrhizal rice under low-temperature stress: a cry for help from the host." Journal of Agricultural Science 153, no. 4 (2014): 602–14. http://dx.doi.org/10.1017/s0021859614000434.

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SUMMARYLow-temperature stress is an important environmental factor that severely disrupts plant respiration but can be alleviated by symbiotic arbuscular mycorrhizal fungi (AMF). In the current study, a pot experiment was performed to determine changes in the respiratory metabolic capacity of mycorrhizal rice (Oryza sativa) under low-temperature stress. The results demonstrated that low temperature might accelerate the biosynthesis of strigolactone in mycorrhizal rice roots by triggering the expression of genes for the synthesis of strigolactone, which acted as a host stress response signal. I

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Haghikia, Aiden, Simon Faissner, Derek Pappas, et al. "Interferon-beta affects mitochondrial activity in CD4+lymphocytes: Implications for mechanism of action in multiple sclerosis." Multiple Sclerosis Journal 21, no. 10 (2014): 1262–70. http://dx.doi.org/10.1177/1352458514561909.

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Background:Whereas cellular immune function depends on energy supply and mitochondrial function, little is known on the impact of immunotherapies on cellular energy metabolism.Objective:The objective of this paper is to assess the effects of interferon-beta (IFN-β) on mitochondrial function of CD4+T cells.Methods:Intracellular adenosine triphosphate (iATP) in phytohemagglutinin (PHA)-stimulated CD4+cells of multiple sclerosis (MS) patients treated with IFN-β and controls were analyzed in a luciferase-based assay. Mitochondrial-transmembrane potential (ΔΨm) in IFN-β-treated peripheral blood mon

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Marteau, Frédéric, Nathalie Suarez Gonzalez, David Communi, Michel Goldman, Jean-Marie Boeynaems, and Didier Communi. "Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells." Blood 106, no. 12 (2005): 3860–66. http://dx.doi.org/10.1182/blood-2005-05-1843.

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Extracellular adenosine triphosphate affects the maturation of human monocyte–derived dendritic cells (DCs), mainly by inhibiting T-helper 1 (Th1) cytokines, promoting Th2 cytokines, and modulating the expression of costimulatory molecules. In this study, we report that adenosine triphosphate (ATP) can induce immunosuppression through its action on DCs, defining a new role for extracellular nucleotides. Microarray analysis of ATP-stimulated human DCs revealed inter alia a drastic up-regulation of 2 genes encoding mediators involved in immunosuppression: thrombospondin-1 (TSP-1) and indoleamine

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Wu, Gong-Jhe, Yih-Giun Cherng, Jui-Tai Chen, Chuen-Chau Chang, Shing-Hwa Liu, and Ruei-Ming Chen. "Genistein Triggers Translocation of Estrogen Receptor-Alpha in Mitochondria to Induce Expressions of ATP Synthesis-Associated Genes and Improves Energy Production and Osteoblast Maturation." American Journal of Chinese Medicine 49, no. 04 (2021): 901–23. http://dx.doi.org/10.1142/s0192415x21500439.

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Our previous study showed that estrogen can induce mitochondrial adenosine triphosphate (ATP) synthesis-associated gene expressions and osteoblast maturation. Genistein, a phytoestrogenic isoflavone that is widely found in various foods and traditional herb products, is beneficial for osteogenesis by selectively triggering estrogen receptor alpha (ER[Formula: see text] expression. In this study, we further investigated the mechanisms of genistein-induced energy production and osteoblast activation. Exposure of rat calvarial osteoblasts and human U-2 OS cells to genistein triggered osteoblast a

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Dillard, Clémentine, Chloé Borde, Ammara Mohammad, et al. "Expression Pattern of Purinergic Signaling Components in Colorectal Cancer Cells and Differential Cellular Outcomes Induced by Extracellular ATP and Adenosine." International Journal of Molecular Sciences 22, no. 21 (2021): 11472. http://dx.doi.org/10.3390/ijms222111472.

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The purine nucleotide adenosine triphosphate (ATP) is known for its fundamental role in cellular bioenergetics. However, in the last decades, different works have described emerging functions for ATP, such as that of a danger signaling molecule acting in the extracellular space on both tumor and stromal compartments. Beside its role in immune cell signaling, several studies have shown that high concentrations of extracellular ATP can directly or indirectly act on cancer cells. Accordingly, it has been reported that purinergic receptors are widely expressed in tumor cells. However, their expres

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Tsutsumi, Yasuo M., Hemal H. Patel, N. Chin Lai, Toshiyuki Takahashi, Brian P. Head, and David M. Roth. "Isoflurane Produces Sustained Cardiac Protection after Ischemia–Reperfusion Injury in Mice." Anesthesiology 104, no. 3 (2006): 495–502. http://dx.doi.org/10.1097/00000542-200603000-00017.

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Background Isoflurane reduces myocardial ischemia-reperfusion injury within hours to days of reperfusion. Whether isoflurane produces sustained cardiac protection has never been examined. The authors studied isoflurane-induced cardiac protection in the intact mouse after 2 h and 2 weeks of reperfusion and determined the dependence of this protection on adenosine triphosphate-dependent potassium channels and the relevance of this protection to myocardial function and apoptosis. Methods Mice were randomly assigned to receive oxygen or isoflurane for 30 min with 15 min of washout. Some mice recei

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Huang, Chongyang, Huanzhou Xu, Xin Zhou, Maili Liu, Jing Li, and Chaoyang Liu. "Systematic Investigations on the Metabolic and Transcriptomic Regulation of Lactate in the Human Colon Epithelial Cells." International Journal of Molecular Sciences 23, no. 11 (2022): 6262. http://dx.doi.org/10.3390/ijms23116262.

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Lactate, primarily produced by the gut microbiota, performs as a necessary “information transmission carrier” between the gut and the microbiota. To investigate the role of lactate in the gut epithelium cell–microbiota interactions as a metabolic signal, we performed a combinatory, global, and unbiased analysis of metabolomic and transcriptional profiling in human colon epithelial cells (Caco-2), using a lactate treatment at the physiological concentration (8 mM). The data demonstrated that most of the genes in oxidative phosphorylation were significantly downregulated in the Caco-2 cells due

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Göttgens, Eva-Leonne, Corina NAM van den Heuvel, Monique C. de Jong, et al. "ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker." Cancers 11, no. 12 (2019): 1971. http://dx.doi.org/10.3390/cancers11121971.

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Radiotherapy is an important treatment modality of head and neck squamous cell carcinomas (HNSCC). Multiple links have been described between the metabolic activity of tumors and their clinical outcome. Here we test the hypothesis that metabolic features determine radiosensitivity, explaining the relationship between metabolism and clinical outcome. Radiosensitivity of 14 human HNSCC cell lines was determined using colony forming assays and the expression profile of approximately 200 metabolic and cancer-related genes was generated using targeted RNA sequencing by single molecule molecular inv

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Dykhuizen, Emily C., Leigh C. Carmody, Nicola Tolliday, Gerald R. Crabtree, and Michelle A. J. Palmer. "Screening for Inhibitors of an Essential Chromatin Remodeler in Mouse Embryonic Stem Cells by Monitoring Transcriptional Regulation." Journal of Biomolecular Screening 17, no. 9 (2012): 1221–30. http://dx.doi.org/10.1177/1087057112455060.

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The SWI/SNF-like adenosine triphosphate (ATP)–dependent chromatin remodeling complex, esBAF, is both necessary and, in some contexts, sufficient to induce the pluripotent state. Furthermore, mutations in various BAF subunits are associated with cancer. Little is known regarding the precise mechanism(s) by which this complex exerts its activities. Thus, it is unclear which protein interactions would be important to disrupt to isolate a relevant readout of mechanism. To address this, we developed a gene expression–based assay to identify inhibitors of the native esBAF complex. Specifically, a qu

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Ferrari, Marco, Agata Negri, Claudia Romeo, et al. "Adenosine Triphosphate–Binding Cassette Transporters Are Not Involved In the Detoxification of Azadirachta indica Extracts In Anopheles stephensi Larvae." Journal of the American Mosquito Control Association 34, no. 4 (2018): 311–14. http://dx.doi.org/10.2987/18-6779.1.

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ABSTRACT Detoxifying pathways of mosquitoes against the neem (Azadirachta indica) extracts are still unclear. The aim of the present study was to investigate the role of adenosine triphosphate–binding cassette (ABC) transporters in this process in Anopheles stephensi, one of the main malaria vectors in southern Asia. Third-stage larvae of An. stephensi were fed with fish food alone or in combination with neem extract at 0.5%, 1%, 5%, and 10%. Six ABC-transporter genes from 3 different subfamilies (B, C, and G) were analyzed to assess their relative expression compared with controls. A bioassay

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Roncalli, Vittoria, Daniela Ascione, Chiara Lauritano, and Ylenia Carotenuto. "The Chemical Defensome: A Survey of Environmental Sensing and Response Genes in Copepods." International Journal of Molecular Sciences 26, no. 4 (2025): 1546. https://doi.org/10.3390/ijms26041546.

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Highly conserved among eukaryotes, the chemical defensome protects organisms against chemical stressors and helps to reestablish the altered homeostatic state. The defensome includes genes such as transporters (e.g., adenosine triphosphate ATP-binding cassette), phase I and phase II detoxification enzymes, and antioxidant enzymes. During their life cycle, planktonic copepods, the most abundant and ubiquitous metazoans on Earth, are exposed to many environmental stressors that impair their survival and fitness. Here, using high-quality publicly available transcriptomic data, defensome genes wer

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Tian, Xin, Renjiao Zhang, Zhengfei Yang, and Weiming Fang. "Methyl Jasmonate and Zinc Sulfate Induce Secondary Metabolism and Phenolic Acid Biosynthesis in Barley Seedlings." Plants 13, no. 11 (2024): 1512. http://dx.doi.org/10.3390/plants13111512.

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This study aimed to reveal the impact of MeJA and ZnSO4 treatments on the physiological metabolism of barley seedlings and the content of phenolic acid. The results showed that MeJA (100 μM) and ZnSO4 (4 mM) treatments effectively increased the phenolic acid content by increasing the activities of phenylalanine ammonia-lyase and cinnamate-4-hydroxylase (PAL) and cinnamic acid 4-hydroxylase (C4H) and by up-regulating the expression of genes involved in phenolic acid synthesis. As a result of the MeJA or ZnSO4 treatment, the phenolic acid content increased by 35.3% and 30.9% at four days and by

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Buakaew, Watunyoo, Rungnapa Pankla Sranujit, Chanai Noysang та ін. "Phytochemical Constituents of Citrus hystrix DC. Leaves Attenuate Inflammation via NF-κB Signaling and NLRP3 Inflammasome Activity in Macrophages". Biomolecules 11, № 1 (2021): 105. http://dx.doi.org/10.3390/biom11010105.

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Citrus hystrix DC. (CH) is found in many countries in Southeast Asia. This plant has been reported for anti-microbial, anti-cancer and anti-inflammatory bioactivities. However, the anti-inflammatory and anti-inflammasome properties of the leaves remain poorly understood. This study aimed to investigate the effect of CH leaves on NLRP3 and NF-κB signaling pathways. CH leaves were sequentially extracted using hexane, ethyl acetate and 95% ethanol to give three crude extracts. An active compound, lupeol was fractionated from the ethanolic extract using chromatographic techniques, and its structur

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Liang, Jinlian, Tianchan Peng, Jinrong Hu, et al. "Lycium barbarum Glycopeptide Promotes Testosterone Synthesis and Glucose Metabolism in Leydig Cells of the Testis." Biomolecules 15, no. 3 (2025): 425. https://doi.org/10.3390/biom15030425.

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Lycium barbarum extracts have been shown to be effective in male reproductive protection and male infertility. However, its role in enhancing testicular function, such as testosterone synthesis, and the potential mechanism remain to be understood. To elucidate the effects of Lycium barbarum glycopeptide (LbGp) on testosterone synthesis, we isolated primary Leydig cells (LCs) from testes and performed RNA sequencing (RNA seq) on LCs treated with LbGp. In this study, we demonstrated that LbGp promoted testosterone synthesis in LCs both in vivo and in vitro. We also demonstrated that LbGp elevate

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Zhang, Bohong, and Mingliang He. "Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis." Cardiovascular Therapeutics 2023 (January 25, 2023): 1–13. http://dx.doi.org/10.1155/2023/5996144.

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Identifying peripheral biomarkers is an important noninvasive diagnosis method for coronary artery disease (CAD) which has aroused the strong interest of researchers. Cuproptosis, a newly reported kind of programmed cell death, is closely related to mitochondrial respiration, adenosine triphosphate (ATP) production, and the TCA cycle. Currently, no studies have been published about the effects of cuproptosis-related genes (CRGs) on diagnosing CAD. To screen marker genes for CAD from CRGs, we downloaded the whole blood cell gene expression profile of CAD patients and normal samples, i.e., the G

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Zhuang, Xiang, Yuwei Chen, Zhenru Wu, et al. "Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain." Carcinogenesis 41, no. 7 (2019): 972–83. http://dx.doi.org/10.1093/carcin/bgz174.

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Abstract Liver cancer and other malignant tumor cells rely on the glycolytic pathway to obtain energy (i.e. the Warburg effect); however, the underlying mechanism is unclear. Mitochondria are sites of oxidative phosphorylation and adenosine triphosphate (ATP) production. The 13 constituent respiratory chain proteins encoded by the mitochondrial genome (namely, mtDNA) play essential roles. We found that in human hepatocellular carcinoma (HCC) tissues, 11 out of the 13 mtDNA-encoded genes exhibited decreased mRNA levels and 5 genes displayed decreased protein levels, including the cytochrome B (

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