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Dissertations / Theses on the topic 'Carbamoyl phosphate synthetase'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Tripathi, Neha. "Inhibition studies of carbamoyl phosphate synthetase from Escherichia coli." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4810.

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Carbamoyl phosphate synthetase (CPS) catalyzes the formation of carbamoyl phosphate (CP) from MgATP, bicarbonate, and glutamine. It has three active sites, one present on the small subunit and the two phosphorylation sites present on the large subunit. These two nucleotide binding sites are homologous. Six compounds were designed to mimic the reactive intermediate species carboxy phosphate, and product cabamoyl phosphate. The apparent Ki values calculated estimated the inhibitory strengths of these compounds. These plots were also utilized in identifying the linear inhibitors, nonlinear inhibi

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2

Kim, Jungwook. "Molecular engineering of oligomerization and metabolite channeling through a molecular tunnel of carbamoyl phosphate synthetase." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/332.

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The oligomerization of CPS from E. coli was investigated in order to examine the influence of this property on the catalytic activity. Mutations at the two interfacial sites of oligomerization were constructed in an attempt to elucidate the mechanism for assembly of the (αβ)4 tetramer through disruption of the molecular binding interactions between monomeric units. The results are consistent with a model for the structure of the (αβ)2 dimer that is formed through molecular contact between two pairs of allosteric domains. No significant dependence of the specific catalytic activity on the prote

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3

Ogura, Masahito. "Overexpresion of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1." Kyoto University, 2010. http://hdl.handle.net/2433/120925.

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4

Wauson, Eric M. Graves Lee M. "The regulation of carbamoyl phosphate synthetase-aspartate transcarbamoylase-dihydroorotase (CAD) by phosphorylation and protein-protein interactions." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1267.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.

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5

Soltys, Carrie-lynn Mary. "Characterization of mitochondrial fatty acylation and identification of a new fatty acylated protein, carbamoyl phosphate synthetase 1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/MQ47099.pdf.

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6

Díez, Fernández Carmen. "USING RECOMBINANT HUMAN CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS1) FOR STUDYING THIS ENZYME'S FUNCTION, REGULATION, PATHOLOGY AND STRUCTURE." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/52855.

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[EN] Carbamoyl phosphate synthetase 1 (CPS1), a 1462-residue mitochondrial enzyme, catalyzes the entry of ammonia into the urea cycle, which converts ammonia, the neurotoxic waste product of protein catabolism, into barely toxic urea. The urea cycle inborn error and rare disease CPS1 deficiency (CPS1D) is inherited with mendelian autosomal recessive inheritance, being due to CPS1 gene mutations (>200 mutations reported), and causing life-threatening hyperammonemia. We have produced recombinantly human CPS1 (hCPS1) in a baculovirus/insect cell expression system, isolating the enzyme in active

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7

Schiller, Tamar M. "Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia." Miami University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1196441446.

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8

Schiller, Tamar Marie. "Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia." Oxford, Ohio : Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1196441446.

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9

Guilloton, Michel. "Déterminisme génétique et rôle physiologique de la cyanate aminohydrolase chez e. Coli : intéraction spécifique du cyanate avec la biosynthèse de l'arginine." Poitiers, 1987. http://www.theses.fr/1987POIT2010.

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10

Laberge, MacDonald Tammy. "Molecular Aspects of Nitrogen Metabolism in Fishes." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/668.

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Molecular aspects of nitrogen metabolism in vertebrates is an interesting area of physiology and evolution to explore due to the different ways in which animals excrete nitrogenous waste as they transition from an aquatic to a terrestrial lifestyle. Two main products of nitrogen metabolism in fishes are ammonia and urea. Ammonia is produced during protein catabolism and build up of ammonia is toxic. Some aquatic vertebrates convert ammonia into a less toxic compound urea via de novo synthesis through the ornithine-urea cycle (O-UC). Five enzymes are involved in the O-UC: carbamoyl phosphat

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11

Lagacé, Monique. "Transcriptional regulation of rat carbamyl phosphate synthetase I gene." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70204.

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The promoter region of the rat gene encoding the enzyme carbamyl phosphate synthetase I (CPS) has been cloned and characterized. The start of transcription was positioned to 138-140 nucleotides upstream of the translation initiation codon. From transient transfection analyses, the functional promoter region of the CPS gene extends 5$ sp prime$ to about 525 nucleotides of the start site of transcription. This promoter region contains six footprinted regions when analyzed in liver nuclear extracts. All sites can be recognized by endogenous C/EBP from liver nuclear extracts while the endogenous D

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12

DAMMERY, HAZARD CLAUDINE. "Hyperammoniemie constitutionnelle par deficit en carbamyl-phosphate synthetase de type i : a propos d'un cas et revue de la litterature." Amiens, 1988. http://www.theses.fr/1988AMIEM102.

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13

Ryall, Jeremiah C. "Regulation of expression of genes encoding carbamyl phosphate synthetase I and ornithine carbamyl transferase." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=73963.

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14

Goping, Ing Swie. "Mechanisms of transcriptional regulation for the rat carbamyl phosphate synthetase I gene." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28760.

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The proximal promoter of the rat carbamyl phosphate synthetase I gene contains 4 cis-acting regulatory regions, designated sites GAC, I, II, and III. Transient transfection assays revealed that the GAG element functions as the main activator element, whereas sites I and III bind repressor proteins and site II binds an anti-repressor. We propose that sites I and III repress the CPS I promoter either by quenching the sole activator(s) bound to the GAG element, or by directly repressing the basal transcription apparatus. Footprint analyses of the promoter with and without a mutation within site I

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15

GUILLOU, FRANCOISE. "Definition des domaines structuraux et fonctionnels de la carbamyl phosphate synthetase d'escherichia coli." Clermont-Ferrand 2, 1990. http://www.theses.fr/1990CLF21261.

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Pour contribuer a la definition des domaines structuraux et fonctionnels de la carbamyl phosphate synthetase d'escherichia coli, nous avons entrepris une analyse mutationnelle de cette enzyme. L'etude de l'effet de deletions sur la formation de l'heterodimere montre que le tiers amino-terminal de la sous-unite glutaminase, ainsi que deux domaines de la sous-unite synthetase, sont impliques dans l'interaction entre les deux sous-unites. Les deux domaines d'interaction situes sur la sous-unite synthetase sont homologues entre eux et sont adjacents aux deux sites atp. L'etude des proprietes catal

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16

Potier, Serge. "Translocation reciproque entre sites chromosomiques choisis : remplacement du locus ura2 sauvage par des alleles deletes in vitro chez saccharomyces cerevisiae." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13121.

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Etude fine du gene ura2 grace aux techniques d'integration chromosomique ou loeus ou remplacement genique et analyse de l'expression, la regulation du gene et du fonctionnement de l'enzyme bifonctionnel codee pae ce gene. Mise au point d'une methode permettant de faire des translocations reciproques stables entre 2 sites choisis

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17

Gautier, Claude. "Evolution et contrôle des enzymes mitochondriales du cycle de l'urée pendant la période périnatale chez le rat." Rouen, 1988. http://www.theses.fr/1988ROUES008.

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18

CHUPIN, BERTRAND. "Oedeme cerebral avec hyperammoniemie au cours d'une intoxication par valpromide : revelation d'un deficit partiel en carbamyl prosphate synthetase de type 1 chez un adulte jeune asymptomatique jusque-la." Angers, 1989. http://www.theses.fr/1989ANGE1006.

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19

Lund, Liliya. "Biophysical and Mechanistic Characterization of Carbamoyl Phosphate Synthetase from Escherichia coli." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8792.

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Carbamoyl phosphate synthetase (CPS) from E. coli catalyzes the formation of carbamoyl phosphate, an intermediate in the biosynthesis of pyrimidine nucleotides and arginine, from glutamine, bicarbonate and two molecules of MgATP. This reaction is catalyzed by three separate active sites that are separated in space by ~100 Å. The transfer of ammonia and carbamate through the two intramolecular tunnels was investigated by molecular dynamics simulations and experimental characterization of mutations within. The presence of an unstable reaction intermediate, carboxyphosphate, was established. A me

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20

Katrib, Marilyn School of Biotechnology &amp Biomolecular Science UNSW. "The malarial carbamoyl phosphate synthetase II gene as a target for DNAzyme therapy." 2007. http://handle.unsw.edu.au/1959.4/40660.

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Today, malaria remains the biggest killer of the third world, killing over a million people every year, despite intensive research efforts. Carbamoyl phosphate synthetase II (CPSII) is the first and rate-limiting enzyme in pyrimidine biosynthesis of Plasmodium falciparum, the causative agent of malaria. PfCPSII is a unique target for DNAzyme therapy due to the presence of two unique insertion sequences of 700bp and 1800bp that exist within the mature mRNA transcript. Previous studies have demonstrated that exogenous delivery of nucleic acids such as ribozymes and DNAzymes targeting PfCPSII ins

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21

Mathomu, Lutendo Michael. "Partial purification and characterization of selected enzymes of bovine nitrogen metabolism : comparison of the Nguni and Hereford breeds." Diss., 2012. http://hdl.handle.net/10500/10060.

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Ruminant animals consuming low N-diet have been reported to have increased urea reabsorption with the Nguni being categorized as N-recycling ruminant. The enzymes associated with N-cycling are hypothesized to contribute to survival of the Nguni in harsh conditions. Enzymes responsible for such a function needed to be characterized in order to determine their effect in the functioning of the Nguni as opposed to Hereford breed. Crude enzymes from both breeds were separated from most or some contaminants by sephadex G-25, DEAE sephacel, and different affinity column chromatography. CPS and GDH we

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