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1

Smithies, Alison. Alpha interferon in the treatment of chronic myeloid leukaemia. R&D Directorate, NHS Executive South and West, 1996.

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2

National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. National Institute for Clinical Excellence, 2003.

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3

National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. National Institute for Clinical Excellence, 2002.

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4

Saglio, Giuseppe, and Carmen Fava. The Treatment of Chronic Myeloid Leukemia. Future Medicine Ltd, 2013. http://dx.doi.org/10.2217/9781780842738.

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5

Brereton, Michelle Lorraine. In vitro growth characteristics of leukaemic and residual normal haemopoietic cells in chronic myeloid leukaemia. University of Salford, 1995.

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6

Hancock, Sarah. Fludarabine as first line therapy for chronic lymphocytic leukaemia. University of Birmingham, Department of Public Health and Epidemiology, 2003.

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7

Chapman, Rachel Susan. Investigation into the relationship between expression of the activated Abelson oncogene, drug sensitivity and suppression of apoptosis in chronic myeloid Leukaemia. University of Manchester, 1995.

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8

M, Carella Angelo, ed. Chronic myeloid leukaemia: Biology and treatment. Martin Dunitz, 2001.

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9

Imatinib Mesylate In The Treatment Of Chronic Myeloid Leukaemia The Malaysian Experience. Lap Lambert Academic Publishing, 2010.

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10

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Bone and soft tissue malignancies. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199689842.003.0025.

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Haematological malignancies examines the epidemiology, genetics, clinical presentation and classification of these diseases, and presents current treatment approaches for each. First are the acute leukaemias, and the management of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). Chronic myeloid leukaemia, its genetics and sensitivity to tyrosine kinase inhibitors, is described. Myelodysplastic syndromes and their management, are followed by chronic lymphoid leukaemias, a large heterogeneous group of diseases, and their treatment. Hodgkin lymphoma, its pathology and presen
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11

McCann, Shaun R. Leukaemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0007.

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The word leukaemia still is associated with foreboding and a fear of premature death. Steady advances have been made in the treatment of childhood leukaemia but, with notable exceptions, the same is not true in adults. The so-called genetic/molecular revolution has extended the understanding of the pathogenesis of many forms of leukaemia but, as yet, has rarely facilitated cure. With the introduction of tyrosine kinase inhibitor therapy, chronic myeloid leukaemia is the obvious exception but it still needs to be seen as to whether the cytogenetic/molecular revolution can provide cures for many
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12

K, Dalziel, and National Co-ordinating Centre for HTA (Great Britain), eds. Effectiveness and cost-effectiveness of imatinib for first-line treatment of chronic myeloid leukaemia in chronic phase: A systematic review and economic analysis. Gray Publishing on behalf of NCCHTA, 2004.

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13

Goldman. Chronic Myeloid Leukaemia. Elsevier, 1988.

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14

M, Goldman John, ed. Chronic myeloid leukaemia. Baillière, 1987.

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15

Goldman, John M. Chronic Myeloid Leukaemia. Elsevier, 1997.

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16

McCann, Shaun R. Molecules, genes, and gene therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0009.

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The twenty-first century has brought many innovations in haematology, with improved diagnostic technology, which may inform treatment choices for malignant diseases, and a better understanding of the genetics and/or epigenetics underlying many diseases. Unfortunately, the aetiology of most of these diseases still eludes us, and some common diseases such as sickle cell disease await simple, inexpensive, and widely available curative treatment. For reasons that are often obscure, some diseases have become fashionable and attract large research financial backing, whereas some do not. With the adv
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17

Annie, Jackson, and Cancer Information Service, eds. Understanding chronic myeloid leukaemia. BACUP, 1989.

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18

Understanding Chronic Myeloid Leukaemia. CancerBACUP (British Association of Cancer United, 1997.

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19

Bunch, Chris. Chronic leukaemia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0287.

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In the chronic leukaemias, leukaemogenesis occurs in two different cell types (and possibly even two different anatomical sites), leading to two very different forms of the disease: chronic myeloid leukaemia and chronic lymphocytic leukaemia. Chronic myeloid leukaemia is best thought of as a myeloproliferative disorder. It is a clonal disorder of the haematopoietic stem cell, leading to overproduction of the myeloid cells: neutrophils and their precursors, basophils and eosinophils. By contrast, chronic lymphocytic leukaemia can be viewed as a low-grade lymphoma. It is a clonal disorder of mat
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20

Bowker, Lesley K., James D. Price, Ku Shah, and Sarah C. Smith. Haematology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198738381.003.0016.

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This chapter provides information on the ageing haematopoietic system, investigating anaemia in older people, diagnosis of iron deficiency anaemia, treatment of iron deficiency anaemia, macrocytic anaemia, anaemia of chronic disease, paraproteinaemias, multiple myeloma, myelodysplasia and myelodysplastic syndrome, and chronic lymphocytic leukaemia.
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21

McCann, Shaun R. Combination chemotherapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0012.

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One of the major advances in haematology during the past six decades has been the development of combination chemotherapy. However, some would dispute the claim that combination chemotherapy has been a major therapeutic advance, arguing that survival for most common cancers has not improved since the advent of chemotherapy. It is certainly true that the survival of children with acute lymphoblastic leukaemia has improved and that the drug imatinib mesylate and its derivatives have changed the outcome for most patients with chronic myeloid leukaemia. Likewise, combination chemotherapy has great
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22

Mendez, Irvin. Acute Myeloid Leukaemia: Symptoms, Diagnosis and Treatment. Nova Science Publishers, Incorporated, 2018.

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23

Chronic Myeloid Leukemia: Biology and Treatment. Informa Healthcare, 2001.

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24

Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Leukaemia. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0004.

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Acute myeloblastic leukaemia (AML) - Acute lymphoblastic leukaemia (ALL) - Chronic myeloid leukaemia (CML) - Chronic lymphocytic leukaemia (B-CLL) - Prolymphocytic leukaemia (PLL) - Hairy cell leukaemia and variant - Large granular lymphocyte leukaemia (LGLL) - Adult T-cell leukaemia-lymphoma (ATLL)
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25

Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Hassan Al-Sader. Leukaemia. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0004_update_001.

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Acute myeloblastic leukaemia (AML) - Acute lymphoblastic leukaemia (ALL) - Chronic myeloid leukaemia (CML) - Chronic lymphocytic leukaemia (B-CLL) - Prolymphocytic leukaemia (PLL) - Hairy cell leukaemia and variant - Large granular lymphocyte leukaemia (LGLL) - Adult T-cell leukaemia-lymphoma (ATLL)
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26

1947-, Talpaz Moshe, and Kantarjian Hagop 1952-, eds. Medical management of chronic myelogenous leukemia. Dekker, 1998.

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27

(Editor), Moshe Talpaz, and Hagop Kantarjian (Editor), eds. Medical Management of Chronic Myelogenous Leukemia (Basic and Clinical Oncology , Vol 16). Informa Healthcare, 1999.

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28

The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: A systematic review. NCCHTA, 2002.

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29

Neureiter, Daniel, Richard Greil, and Lisa Pleyer. Chronic Myeloid Neoplasias and Clonal Overlap Syndromes: Epidemiology, Pathophysiology and Treatment Options. Springer, 2011.

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30

Chronic Myeloid Neoplasias And Clonal Overlap Syndromes Epidemiology Pathophysiology And Treatment Options. Springer, 2010.

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31

Ajithkumar, Thankamma, Ann Barrett, Helen Hatcher, and Natalie Cook. Paediatric malignancies. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235636.003.0015.

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Leukaemia is the commonest cancer (accounting for >40% of cases) in children. It is a clonal proliferation of stem cells which leads to bone marrow failure and tissue infiltration.• Acute lymphoblastic leukaemia (ALL): 4/100,000• Acute myeloid leukaemia (AML): 0.7/100,000• Chronic myeloid leukaemia (CML): 0.2/100,000...
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32

Carton, James. Haematopathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759584.003.0015.

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This chapter discusses haematopathology, including iron deficiency anaemia, anaemia of chronic disease, megaloblastic anaemias, hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency, thalassaemias, sickle-cell disorders, idiopathic thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), von Willebrand disease, haemophilia, thrombophilia, acute B-lymphoblastic leukaemia, acute myeloid leukaemias, chronic lymphocytic leukaemia (CLL), chronic myelogenous leukaemia, polycythaemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF), myelodyspl
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33

Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Paediatric haematology. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0012.

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Blood counts in children - Red cell transfusion and blood component therapy—special considerations in neonates and children - Polycythaemia in newborn and childhood - Neonatal anaemia - Anaemia of prematurity - Haemolytic anaemia in the neonate - Congenital red cell defects - Acquired red cell defects - Haemolytic disease of the newborn - Hyperbilirubinaemia - Neonatal haemostasis - Neonatal alloimmune thrombocytopenia - Congenital dyserythropoietic anaemias - Congenital red cell aplasia - Acquired red cell aplasia - Fanconi anaemia - Rare congenital marrow failure syndromes - Neutropenia in c
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34

Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Angela Theodoulou. Paediatric haematology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0012_update_001.

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Blood counts in children - Red cell transfusion and blood component therapy—special considerations in neonates and children - Polycythaemia in newborn and childhood - Neonatal anaemia - Anaemia of prematurity - Haemolytic anaemia in the neonate - Congenital red cell defects - Acquired red cell defects - Haemolytic disease of the newborn - Hyperbilirubinaemia - Neonatal haemostasis - Neonatal alloimmune thrombocytopenia - Congenital dyserythropoietic anaemias - Congenital red cell aplasia - Acquired red cell aplasia - Fanconi anaemia - Rare congenital marrow failure syndromes - Neutropenia in c
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35

Mughal, Tariq I., and Tiziano Barbui, eds. Oxford Specialist Handbook: Myeloproliferative Neoplasms. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198744214.001.0001.

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Our understanding of myeloproliferative neoplasms (MPN) disorders, a group of clonal haematological malignancies characterized by excessive accumulation of one or more myeloid cell lineages, has grown considerably over the past four decades. Even more importantly is the speed at which many of these findings were translated to accord survival benefits to our patients with MPN, in particular chronic myeloid leukaemia (CML), polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF). This text offers a detailed evidence-based guide to MPN in an easily accessible for
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36

Weinberg, Robert A., and Jessica Wapner. Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment. Experiment LLC, The, 2014.

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37

Collins, Graham, and Chris Bunch. Myeloproliferative disorders. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0291.

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Myeloproliferative disorders (also called myeloproliferative neoplasms) can be defined as clonal haematopoietic disorders resulting in excess production of one or more blood cell lineage. The four main conditions are primary polycythaemia, which is characterized by excess red-cell production; essential thrombocythaemia, which is characterized by excess platelet production; chronic myeloid leukaemia, which is characterized by excess granulocyte production; and myelofibrosis, which is characterized by excess megakaryocyte proliferation, which results in a reactive fibroblast proliferation causin
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