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Dissertations / Theses on the topic 'Clinical and immunological changes'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Gibson, John. "Orofacial granulomatosis : clinical and immunological studies." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266680.

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2

Huang, Dennis Shihchang. "Immunological changes in retrovirus-infected mice." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186463.

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Acquired Immune Deficiency Syndrome (AIDS), a progressive immunodeficiency induced by Human Immunodeficiency Virus (HIV), frequently sets the stage for life-threatening tumors and opportunistic infections. The proposed study focuses on the immunological changes associated with HIV infection. Often superimposed diarrhea, causing malabsorption and malnutrition, leads to further immunosuppression and accelerated deterioration in many patients. The pathomechanism of Cryptosporidium-induced diarrhea is poorly understood and its relation to AIDS urgently requires investigation. We used LP-BM5 murine

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3

Sjöwall, Johanna. "Clinical and Immunological Aspects of Lyme borreliosis." Doctoral thesis, Linköpings universitet, Infektionsmedicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68745.

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Lyme borreliosis (LB) is a tick-borne infection caused by spirochetes of the Borrelia (B.) burgdorferi sensu lato complex. The infection is associated with several clinical features, of which erythema migrans (EM) and neuroborreliosis (NB) are the most common in Europe. The prognosis after antibiotic therapy is generally good. However, some patients may have residual symptoms post-treatment. The cause of the delayed convalescence is unclear. There are several factors that may affect the clinical outcome of LB, for example, the early interaction between the host’s immune response and B. burgdor

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4

Fennerty, A. G. "Clinical and immunological studies in hay fever." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382062.

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5

Hourihane, Jonathan O'Brien. "Clinical & immunological features of peanut allergy." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242421.

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6

Kitley, Joanna Louise. "A clinical/immunological neuromyelitis optica association study." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:274bb81c-edce-4f6f-8330-172659ba99fc.

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Neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) are associated with the disease-specific autoantibody aquaporin-4 (AQP4-Ab), which is thought to be pathogenic. Some NMO/NMOSD patients do not have this antibody and may have different clinical and immuno-pathological disease characteristics, but previous clinical NMO/NMOSD studies have been confounded by inclusion of such patients. To define better the characteristics of AQP4-Ab disease, disease course, outcomes and predictors of disability were investigated in 106 AQP4-Ab positive NMO/NMOSD patients from the UK and Japan. AQP4-Ab

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7

Bernstrand, Cecilia. "Langerhans cell histiocytosis : a clinical and immunological study /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-468-2/.

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8

Hedin, Skogman Barbro. "Neuroborreliosis in childhood : Clinical, immunological and diagnostic aspects." Doctoral thesis, Linköpings universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11520.

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Lyme Borreliosisis is a multi-organ infectious disease caused by the spirochete Borrelia burgdorferi. The spirochete is transmitted to humans by tick bites. Neuroborreliosis (NB) is a disseminated form of the disease, in which the spirochetes invade the nervous system. In children, subacute meningitis and facial nerve palsy are typical clinical manifestations of NB. The aim of this thesis was to study clinical, immunological and laboratory characteristics in children being evaluated for NB in a Lyme endemic area of Sweden, in order to identify factors of importance for prognosis and clinical r

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9

Robertson, William Duncan. "Oral keratoses : a clinical, pathological and immunological study." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/20152.

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The diagnosis of a patient presenting with an oral keratosis is the first stage in the management of the patient. Diagnosis is based on a combination of patient history, clinical examination and laboratory investigations. The aim of this thesis was to identify factors which may be helpful in the diagnosis of oral keratoses. It is based on a prospective study of 159 patients being examined haematologially, immunologically and histopathologically. Two main groups of keratoses were identified by the presence or absence of an associated inflammatory cell infiltrate. Infiltrated keratoses comprised

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10

Söderlund, Stina. "Clinical and Immunological Studies in Chronic Myeloid Leukaemia." Doctoral thesis, Uppsala universitet, Hematologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-324272.

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Chronic myeloid leukaemia (CML) is characterised by the constitutively active tyrosine kinase BCR-ABL. Standard treatment with tyrosine kinase inhibitors (TKI) in the chronic phase (CP) of CML conveys excellent long-term prognosis but is associated with side effects and costs. Treatment free remission (TFR) is possible in a proportion of patients discontinuing treatment after obtaining deep treatment responses but it is not fully known how to select the right patients for stopping attempts. Treatment of accelerated phase (AP) and blast crisis (BC) is more complicated and the prognosis more dis

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11

Blount, Daniel Graham. "Age-related immunological changes in labrador retriever dogs." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436864.

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12

Clark, Andrew Thomas. "Development of multiple nut allergy : clinical and immunological studies." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409414.

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13

Jablonowska, Barbara. "Recurrent spontaneous abortion : a clinical, immunological and genetic study /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med772s.pdf.

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14

Tengvall, Linder Maria. "Immunological mechanisms in atopic dermatitis : clinical and experimental studies /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3217-4/.

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15

Norbeck, Oscar. "Clinical and immunological aspects of human parvovirus B19 infection /." Stockholm : Dept. of laboratory medicine, Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-203-9/.

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16

OKAMOTO, SUSUMU, AKlRA TAKAHASHI, TOSHIHIKO TAKEGAMI, and KAZUO MANO. "Remission of Myasthenia Gravis: Clinical, Electrophysiological and Immunological Studies." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17540.

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17

Davison, Lucy Jane. "A clinical and immunological study of canine diabetes mellitus." Thesis, Royal Veterinary College (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411735.

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18

Thomas, Paul David. "Clinical and immunological investigations on the pathogenesis of pouchitis." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391128.

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19

Thoday, Keith Lawrence. "Clinical, biochemical and immunological studies of feline thyroid function." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/30022.

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20

SERAFINI, GIORGIA. "IL-10 mediated immunological tolerance: preclinical and clinical studies." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1022.

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Thalassemia Major can be cured with allogeneic hematopoietic stem-cell transplantation (HSCT). Persistent mixed chimerism (PMC) develops in around 10% of transplanted thalassemic patients, but the biological mechanisms underlying this phenomenon are poorly understood. IL-10 is an immunomodulant cytokine that plays a central role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. Detection of high levels of IL-10, produced by PBMCs of patients with PMC, in comparison to those of patients with complete donor chimerism (CC) or normal donors (ND),

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21

de, Boniface Jana. "Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7890.

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22

Österlundh, Ingrid. "Coliform mastitis in the sow : clinical immunological studies around parturition /." Uppsala : Dept. of Obstetrics and Gynaecology, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/v146-ab.html.

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23

Trebble, Timothy Mark. "The clinical and immunological response to fish oil in Crohn's disease." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438965.

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24

Lundin, Jeanette. "Targeted CD52 therapy in lymphoid malignancies : a clinical and immunological study /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-441-0/.

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25

Boström, Lennart. "Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4456-3/.

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26

Sparrelid, Elda. "Infections in allogeneic stem cell transplanted patients : clinical and immunological aspects /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4840-2/.

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27

Saleem, Benazir. "The clinical, imaging and immunological phenotype of remission in inflammatory arthritis." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588745.

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The aim of this thesis was to identify and compare objective measures and predictors of remission. This was done in a cohort of patients with established RA, early RA and very early undifferentiated arthritis with poor prognostic markers. The objective markers used to define the remission state included clinical (remission scores, clinical examination, inflammatory markers and antibody status), imaging (ultrasound [US] assessment for power Doppler [PD] activity) and immunology (assessment of T cell subtypes) assessments. In patients with established RA treated with combination TNF blocker ther

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28

Salih, Abdelrazig Mustafa. "A clinical and immunological study of peripheral neuropathy in rheumatoid arthritis." Thesis, Keele University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318158.

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29

CONTEDUCA, VINCENZA. "Pathophysiology of HCV-Related cryoglobulinemic vasculitis: molecular, immunological and clinical analysis." Doctoral thesis, Università di Foggia, 2015. http://hdl.handle.net/11369/338382.

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ABSTRACT INTRODUZIONE: L’infezione da virus dell’epatite C (HCV) rappresenta la principale causa di malattia cronica del fegato, che può evolvere in cirrosi e carcinoma epatocellulare (HCC). L’infezione cronica da HCV è inoltre caratterizzata dall’insorgenza di diverse manifestazioni extraepatiche, la più comune delle quali è la crioglobulinemia mista (MC). Si tratta di una vasculite mediata da immunocomplessi che coinvolge vasi sanguigni di piccolo calibro, caratterizzata da una proliferazione B-cellulare con possibile evoluzione in linfoma non-Hodgkin a cellule B. Il caratteristico tropism

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30

Timmons, Brian Weldon Bar-Or Oded. "Immunological changes in response to acute exercise, considering puberty and sex /." *McMaster only, 2005.

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31

Broström, Christina. "Slow progression in HIV-1 infection : a clinical, virological and immunological study /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980603bros.

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32

Apatzidou, Danae Anastasia. "Clinical, microbiological and immunological responses to two non-surgical periodontal treatment modalities." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394964.

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33

Lucas, Jane Sarah Anne. "The clinical & immunological characteristics of kiwi fruit allergy in the UK." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427336.

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34

Willis, Mark. "A clinical and immunological study of CD8+ T cells in multiple sclerosis." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/108478/.

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Prior focus has largely been on the role of CD4+ T cells in Multiple sclerosis (MS) disease pathogenesis, but there is mounting evidence for the role of CD8+ T cells. This thesis aimed to explore the role of CD8+ T cells by; (i) analysing clinical outcomes in MS patients treated with alemtuzumab, (ii) performing an in-depth phenotypic analysis of cerebrospinal fluid (CSF)-resident T cells in MS patients, (iii) examining the CSFresident T cell receptor (TCR) repertoire in MS patients, and; (iv) identifying the pathogenic triggers/antigenic targets of dominant CSF-resident TCRs. Alemtuzumab was

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35

Joubert, Bastien. "Autoimmune neurological syndromes with anti- CASPR2 antibodies : clinical, immunological and genetic characterization." Thesis, Lyon, 2019. https://n2t.net/ark:/47881/m6xp749b.

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Les auto-anticorps dirigés contre CASPR2 (Contactin-2 Associated Protein), une protéine d'adhésion neuro-gliale, ont été décrits dans au moins trois syndromes neurologiques auto-immuns: l'encéphalite limbique auto-immune, la neuromyotonie acquise et le syndrome de Morvan. Cependant, le phénotype clinique associé aux anticorps anti-CASPR2 demeure imparfaitement décrit. Ce travail de thèse vise à décire les présentations cliniques des patients avec anticorps anti-CASPR2. La première étude est consacrée à l'analyse de la présentation clinique et du pronostic de l'encéphalite limbique auto-immune

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36

del, Fierro Gloria M. "Clinical, immunological and pathological aspects of experimental feline immunodeficiency virus (FIV) infection." Thesis, del Fierro, Gloria M. (1995) Clinical, immunological and pathological aspects of experimental feline immunodeficiency virus (FIV) infection. PhD thesis, Murdoch University, 1995. https://researchrepository.murdoch.edu.au/id/eprint/53477/.

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Feline immunodeficiency virus is a recently discovered feline lentivirus which clinically resembles human HIV-1 virus inducing immune dysfunction and secondary infections in cats. FIV presence has been confirmed throughout the world in domestic, feral and zoo cat populations. Older, free-roaming, diseased male cats are at the greatest risk of acquiring the infection. There are no specific clinical signs restricted to FIV infection. However, weight loss, recurrent fever of undetermined origin, unthriftiness, inappetence, pyrexia, lymphadenopathy, anaemia, leucopenia and myeloproliferative d

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37

Abdalla, Amir Osman. "Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-114-2/.

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38

Bertolaccini, Maria Laura. "Antiprothrombin antibodies : detection, immunological characteristics and clinical significance in patients with antiphospholipid syndrome." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408765.

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39

Humby, Frances Claire. "The clinical and immunological significance of ectopic lymphoneogenesis in the rheumatoid synovial membrane." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28086.

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Despite the development of new biomarkers predicting prognosis in rheumatoid arthritis (RA) remains challenging and targeting of powerful biologics difficult. The presence of ectopic germinal centres (GC) within synovium has long been recognised (ectopic lymphoneogenesis [ELN]) and data have suggested that they manufacture antibody (Ab). High affinity class switched Ab production occurs through class switch recombination (CSR) and somatic hypermutation (SHM) both critically dependent on activation induced cytidine deaminase (AID). However, whether ectopic GCs express AID has not been known. No

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40

Malm, Christer. "Immunological changes in human blood and skeletal muscle in response to physical exercise /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-035-0/.

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41

Schoeman, Tanya. "Clinical and clinico-pathological changes in feline babesiosis." Diss., Electronic thesis, 2001. http://upetd.up.ac.za/thesis/available/etd-03232005-133808/.

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42

Mohammed, N. A. "The renal glomerulus of the dog : Its normal structure and its reaction to immunological injury." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379301.

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43

Bejon, Philip. "Clinical and immunological evaluation of new malaria vaccines encoding the thrombospondin related adhesion protein." Thesis, Open University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441151.

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44

Remus, Natascha. "Genetic epidemiologic of the response to Mycobacterium tuberculosis : investigation of clinical and immunological phenotypes." Paris 5, 2008. http://www.theses.fr/2008PA05T042.

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La tuberculose (TB) demeure un problème majeur de la santé publique mondiale et il est connu que des facteurs génétiques influencent la susceptibilité de l'hôte à l'infection par M. Tuberculosis. Nous avons étudié les gènes NRAMP1, qui a été associé à la susceptibilité à la tuberculose dans plusieurs groupes ethniques, etIL12RBl, qui joue un rôle majeur dans la susceptibilité Mendélienne aux infections mycobactériennes (MSMD), et nous n'avons pas trouvé une association avec la TB pulmonaire dans une population adulte Marocaine. Par conséquent, la susceptibilité complexe à la TB maladie dans ce

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45

Kronqvist, Marianne. "Clinical and immunological studies of respiratory allergy among farmers : with focus on dust mite allergy /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4411-3/.

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46

Örtqvist, Eva. "The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4632-9/.

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47

Cuthbert, Robert J. G. "Clinical and immunological studies on a cohort of haemophiliacs infected with the human immunodeficiency virus." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335965.

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48

Sporik, Richard Bernard. "The natural history of allergic diseases in children : a prospective clinical, immunological and environmental study." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295805.

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49

Kubasch, Anne Sophie, Rebekka Wehner, Serena Bazzurri, et al. "Clinical, molecular, and immunological responses to pembrolizumab treatment of synchronous melanoma and acute myeloid leukemia." American Society of Hematology, 2018. https://tud.qucosa.de/id/qucosa%3A34908.

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Cancer cells use the interaction between immune-checkpoint receptor programmed cell death protein 1 (PD-1) on activated T cells and programmed cell death ligand 1 (PD-L1) on tumor cells and various cell types of the tumor microenvironment to evade immune surveillance. Blocking the interaction between PD-1 and PD-L1 with checkpoint inhibitors can improve T-cell reactions and mediate efficient antitumor activity in a variety of solid tumors including melanoma. However, clinical data from patients with myeloid diseases that are treated with these agents are limited to clinical trials in advanced

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50

Lai, Sum Wing Christina. "An Analysis of Strategies Targeting Early Clinical and Immunological Events to Improve Kidney Transplant Outcomes." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29651.

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Background: Kidney transplantation is an essential treatment for patients with end-stage renal failure. The long-term fate of the transplant often depends on early events, including the development of delayed graft function (DGF) and rejection. However, there are barriers to targeting these risk factors to improve outcomes. First, DGF is associated with an increased incidence of acute rejection, but there is a lack of consensus around how to diagnose DGF. Second, despite growing recognition of the role of inflammatory monocytes (MΦ) in rejection, no clinically available treatment specifically

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