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Journal articles on the topic 'Clinical and immunological changes'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Schwab, Nicholas, Karin G. Höhn, Tilman Schneider-Hohendorf, et al. "Immunological and clinical consequences of treating a patient with natalizumab." Multiple Sclerosis Journal 18, no. 3 (2011): 335–44. http://dx.doi.org/10.1177/1352458511421919.

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Background: Long-term therapy with natalizumab increases the risk of progressive multifocal leukoencephalopathy (PML). Objectives: We present a patient study through therapy, the diagnosis of PML (after 29 infusions), plasma exchange (PE) and development of immune reconstitution inflammatory syndrome (IRIS). Methods: Routine diagnostics, magnetic resonance imaging (MRI), immunological status (flow cytometry, T-cell migration assays and T-cell repertoire analysis), and brain biopsy with immunohistological analysis. Results: CD49d decreased after 12 months of treatment. At PML diagnosis, CD49d e

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2

Maruf, Gadoev, and Bakhromuddin Saidzoda. "CLINICAL AND IMMUNOLOGICAL CHANGES OF NON-GONOCOCCAL URETHRITIS." Avicenna Bulletin 22, no. 1 (2020): 40–44. http://dx.doi.org/10.25005/2074-0581-2020-22-1-40-44.

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Objective: To study the clinical features and the state of general immunological reactivity in non-gonococcal urethritis (NGU) in men. Methods: Examined 100 men between the ages of 20 and 48 years: 75 patients of NGU (main group) and 25 healthy (control group). The average age of the patients was 26.7±1.7 years, and the male of control group was 27.9±1.7 years. Clinical, microscopic, immunological research methods were used, including direct immunofluorescence (DIF), polymerase chain reaction (PCR). Results: Ureaplasma urealyticum was found in 37 (49.3%) patients, 33 (44%) had Chlamydia tracho

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Tamási, Lilla, Ildikó Horváth, Anikó Bohács, Veronika Müller, György Losonczy, and Michael Schatz. "Asthma in pregnancy – Immunological changes and clinical management." Respiratory Medicine 105, no. 2 (2011): 159–64. http://dx.doi.org/10.1016/j.rmed.2010.11.006.

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4

HILL, D. J., C. S. HOSKING, M. J. SHELTON, and M. W. TURNER. "Childhood asthma: clinical and immunological changes over a decade." Clinical Experimental Allergy 21, no. 3 (1991): 343–49. http://dx.doi.org/10.1111/j.1365-2222.1991.tb01666.x.

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5

Tylutka, Anna, and Agnieszka Zembroń-Łacny. "Immunological aging and clinical consequences." Postępy Higieny i Medycyny Doświadczalnej 74 (July 8, 2020): 260–71. http://dx.doi.org/10.5604/01.3001.0014.3054.

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Immunosenescence is defined as the changes in the immune system associated with age. It is a progressive and irreversible process involving a decrease in the number of naïve T and B cells, NK cells cytotoxic and activity, and disruption of pro and anti-inflammatory balance by altering the production of IL-2, -4, -6, -10, -10, TNF-α, interferon γ and others. With age there is an increase in autoimmunity and generalized inflammation with simultaneous immunodeficiency, which results in greater susceptibility to infectious diseases, a decrease in reactivity to prophylactic vaccinations, the incide

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Zhou, Julie Y., and Brian A. Cobb. "Glycans in Immunologic Health and Disease." Annual Review of Immunology 39, no. 1 (2021): 511–36. http://dx.doi.org/10.1146/annurev-immunol-101819-074237.

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The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on

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Baars, Erik W., Miek Jong, Andreas F. M. Nierop, Inge Boers, and Huub F. J. Savelkoul. "Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety." ISRN Allergy 2011 (July 18, 2011): 1–11. http://dx.doi.org/10.5402/2011/836051.

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Background. Clinical experiences in vitro and clinical studies have demonstrated the curative potency and safety of Citrus/Cydonia compositum in seasonal allergic rhinitis treatment. Objectives. To compare the efficacy and safety of two routes of administration (nasal spray versus subcutaneous injections). Methodology: Design. a national, randomised, comparative clinical trial with two parallel groups. Participants. 23 patients fulfilled the study requirements. Intervention. after a one- or two-week wash-out period, 23 patients were randomized, to a 6-week treatment period. Outcomes. immunolog

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Taylor, J., R. Afrasiabi, JL Fahey, E. Korns, M. Weaver, and R. Mitsuysau. "Prognostically significant classification of immune changes in AIDS with Kaposi's sarcoma." Blood 67, no. 3 (1986): 666–71. http://dx.doi.org/10.1182/blood.v67.3.666.666.

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Abstract Sixteen immunological parameters were assessed quantitatively for their value in providing an immunologically-based and prognostically significant classification of the immune alteration in 97 patients with AIDS and Kaposi's sarcoma (AIDS-KS). The dimensions of reductions in the T4 (T helper-inducer cells) subpopulation of lymphoid cells in the T4-T8 ratio were found to correlate most closely with prognosis. Most other immunological changes did not relate to clinical course. T4 lymphocyte levels greater than 300/microL and a T4-T8 ratio greater than 0.5 indicated a relatively good pro

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Taylor, J., R. Afrasiabi, JL Fahey, E. Korns, M. Weaver, and R. Mitsuysau. "Prognostically significant classification of immune changes in AIDS with Kaposi's sarcoma." Blood 67, no. 3 (1986): 666–71. http://dx.doi.org/10.1182/blood.v67.3.666.bloodjournal673666.

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Sixteen immunological parameters were assessed quantitatively for their value in providing an immunologically-based and prognostically significant classification of the immune alteration in 97 patients with AIDS and Kaposi's sarcoma (AIDS-KS). The dimensions of reductions in the T4 (T helper-inducer cells) subpopulation of lymphoid cells in the T4-T8 ratio were found to correlate most closely with prognosis. Most other immunological changes did not relate to clinical course. T4 lymphocyte levels greater than 300/microL and a T4-T8 ratio greater than 0.5 indicated a relatively good prognosis, e

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Axmedovich, Makhmudov Farxod, Sharopova Gulnoza Samadovna, and Sultonov Sohib Obidovich. "Observation of immunological changes during clinical cycles of skin leishmaniosis." ACADEMICIA: An International Multidisciplinary Research Journal 11, no. 5 (2021): 618–22. http://dx.doi.org/10.5958/2249-7137.2021.01449.x.

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Perezábad, Laura, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, and Iván López-Expósito. "Clinical efficacy and immunological changes subjacent to egg oral immunotherapy." Annals of Allergy, Asthma & Immunology 114, no. 6 (2015): 504–9. http://dx.doi.org/10.1016/j.anai.2015.04.006.

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12

Pedrosa, Elisabet, Violeta Lorén, Eduard Cabré, et al. "Bacteria and spontaneous experimental colitis: immunological changes." European Journal of Clinical Investigation 41, no. 10 (2011): 1047–53. http://dx.doi.org/10.1111/j.1365-2362.2011.02499.x.

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13

Flores, Erica B., Bulent A. Aksoy, and Eric Bartee. "Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication." Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000804. http://dx.doi.org/10.1136/jitc-2020-000804.

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BackgroundOncolytic therapy uses live-replicating viruses to improve the immunological status of treated tumors. Critically, while these viruses are known to self-amplify in vivo, clinical oncolytic therapies still appear to display a strong dose dependence and the mechanisms mediating this dose dependence are not well understood.MethodsTo explore this apparent contradiction, we investigated how the initial dose of oncolytic myxoma virus affected the subsequent ability of treatment to alter the immunological status of tumors as well as synergize with programmed cell death protein 1 (PD1) block

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Blinchikova, M. S., and A. V. Zhestkov. "BRONCHIAL ASTHMA AND SMOKING: CLINICAL FEATURES AND DIAGNOSTICS." Russian Journal of Allergy 11, no. 6 (2014): 20–24. http://dx.doi.org/10.36691/rja492.

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Background. Improvement of the results of diagnostics and optimization of treatment of adult patients with bronchial asthma on the basis of clinical, immunological and microbiological features of the disease. Methods. The study included 150 patients with bronchial asthma at the age from 18 till 65 years old (the average age - 51,8 years old). Results. It was proven, that smoking patients with bronchial asthma had upgraded levels of the inducing inflammation cytokines and reduced concentration of antiinflammatory IL-10. These changes were more expressed in a long lasting active smoking patients

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Srivastava, Deepsikha, Shailendra Nath Gaur, Naveen Arora, and Bhanu Pratap Singh. "Clinico-immunological changes post-immunotherapy with Periplaneta americana." European Journal of Clinical Investigation 41, no. 8 (2011): 879–88. http://dx.doi.org/10.1111/j.1365-2362.2011.02480.x.

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16

Noga, Oliver, Gerald Hanf, and Gert Kunkel. "Immunological and Clinical Changes in Allergic Asthmatics following Treatment with Omalizumab." International Archives of Allergy and Immunology 131, no. 1 (2003): 46–52. http://dx.doi.org/10.1159/000070434.

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17

Vasichkina, Elena, Daria Alekseeva, Igor Kudryavtsev, et al. "COVID-19 Heart Lesions in Children: Clinical, Diagnostic and Immunological Changes." International Journal of Molecular Sciences 24, no. 2 (2023): 1147. http://dx.doi.org/10.3390/ijms24021147.

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In the beginning of COVID-19, the proportion of confirmed cases in the pediatric population was relatively small and there was an opinion that children often had a mild or asymptomatic course of infection. Our understanding of the immune response, diagnosis and treatment of COVID-19 is highly oriented towards the adult population. At the same time, despite the fact that COVID-19 in children usually occurs in a mild form, there is an incomplete understanding of the course as an acute infection and its subsequent manifestations such as Long-COVID-19 or Post-COVID-19, PASC in the pediatric popula

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18

Mazhitova, N., R. Kalmatov, G. Abdykaimova, and Zh Abdullaeva. "Clinical-pathological Changes in Reproductive Age Women With Autoimmune Thyroiditis." Bulletin of Science and Practice 7, no. 9 (2021): 354–59. http://dx.doi.org/10.33619/2414-2948/70/31.

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Research relevance: Autoimmune pathology of the thyroid gland is one of the urgent problems of modern endocrinology, and this is due to the lack of clarity of pathogenetic mechanisms and the lack of objective and reliable diagnostic methods, including immunological. The mechanisms of autoimmune thyroid diseases have not yet been fully elucidated, although about a hundred years have passed since the first description of autoimmune thyroiditis. According to world statistics, thyroid disease occurs in almost 30% of the world’s population. According to the latest data, in Kyrgyzstan, they are foun

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Sabirova, Dilnoza Shukhratovna, Samandar Vokhidjon ogli Tashniyozov, Sakhiyor Ilhom ogli Yarmamatov, Sunnatulla Jamal ogli Tashturdiyev, and Farangis Abduhakim kizy Choriyeva. "IMMUNOLOGIC CHANGES IN DIFFUSE TOXIC GOITERS." Research and implementation, no. 4 (March 19, 2024): 134–41. https://doi.org/10.5281/zenodo.10837682.

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<em>This review of the article is devoted to an actual disease in the field of endocrinology, such as DTB. It has been shown that the clinical manifestations of the disease are associated with multiple secretions of thyroid hormones that affect several systems at the same time. The immunological mechanisms of the formation of the disease are indicated. Damage to the cardiovascular system is a frequent serious complication of DTB, and it often ranks first among cardiovascular diseases. Its clinical presentation and determination of the course and outcome of the disease are explained</em>

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20

Ovcharenko, Mykola, Yevgeny Verbitsky, Iryna Chumakova, and Yuliia Yevtushenko. "Clinical significance of immunological indicators in the remote period after traumatic brain injury." Ukrains'kyi Visnyk Psykhonevrolohii, Volume 32, issue 1 (118), 2024 (March 20, 2024): 19–23. http://dx.doi.org/10.36927/2079-0325-v32-is1-2024-3.

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The article describes the clinical significance of immunological indicators in the remote period after traumatic brain injury (TBI). Immunological indicators take a key role in determining the clinical outcomes in the remote period of TBI, as they reflect the state of the body’s immune reactivity and correlate with the body’s ability to recover. Changes in both humoral and cellular immunity have been observed in patients with TBI. Variations in immunological parameters can serve as predictors for assessing the rehabilitative potential of patients after TBI. Key words: traumatic brain injury, c

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21

Jiang, Chao, Jianping Wang, and Haidong Lu. "Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases." Case Reports in Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/203602.

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We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that immunological abnormalities are present in the specimens of certain childhood-onset NM patients without autoimmune diseases. Further evaluation of the immunological changes is warranted in childhood-onset N

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22

NOVIKOVA, I. A., A. V. GOMOLYAKO, and M. V. ZLOTNIKOVA. "Clinical and immunological aspects of recurrent, bacterial and viral skin affections." Vestnik dermatologii i venerologii 87, no. 2 (2011): 44–48. http://dx.doi.org/10.25208/vdv993.

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The authors analyzed the subpopulation composition of lymphocytes in the peripheral blood of 69 patients suffering from chronic recurrent furunculosis and herpes at the stage of remission. They revealed similar changes in the form of an increased content of T-helpers and immunoregulatory index. In herpes patients such changes are accompanied with the reduced number of natural killers while in furunculosis patients changes are related to the reduced amount of activated T-lymphocytes. These changes do not depend on the relapse duration or frequency but are related to the number of exacerbations

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Fazleeva, L. K., N. A. Romanova, and I. Sh Trofimova. "Clinical and immunologic changes in newborns in late toxicosis of pregnancy." Kazan medical journal 68, no. 4 (1987): 259–61. http://dx.doi.org/10.17816/kazmj96126.

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The aim of this work was to study the features of humoral immunity in 198 newborns depending on the duration of maternal treatment during pregnancy for late toxicosis. Immunological changes were judged by the levels of serum immunoglobulins A, M, G and E, circulating immune complexes and by the activity of the kinin system.

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Sabitov, A. U., D. A. Soldatov, and Yu B. Khamanova. "Clinical and immunological features of opisthorchiasis." Kazan medical journal 102, no. 5 (2021): 626–35. http://dx.doi.org/10.17816/kmj2021-626.

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Aim. To assess the clinical and immunological features in patients with chronic opisthorchiasis, depending on the duration of the infection. Methods. The first group consisted of 19 patients with the duration of the infection up to 1 year, the second group consisted of 21 patients with the duration of the infection between 1 and 5 years, the third group was formed of 23 patients with the duration of the disease more than 5 years, the control group 20 healthy individuals. Immunological research was carried out at the Clinical Diagnostic Center. Statistical processing was performed using M

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Rouleau, Pascal, Roth-Visal Ung, Nicolas P. Lapointe, and Pierre A. Guertin. "Hormonal And Immunological Changes in Mice after Spinal Cord Injury." Journal of Neurotrauma 24, no. 2 (2007): 367–78. http://dx.doi.org/10.1089/neu.2006.0117.

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26

Makienko, NV, VV Minukhin, TI Kolyada, II Toryanyk, and АI Sklyar. "The main clinical and immunological aspects of post-COVID syndrome." Annals of Mechnikov Institute, no. 3 (September 12, 2022): 21–27. https://doi.org/10.5281/zenodo.7070908.

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COVID-19 pandemic has encouraged many researchers to focus on the formation of further changes in the human body caused by SARS-CoV-2, as well as to study the epidemiological, pathophysiological and immunological processes of coronavirus disease in the long term in order to determine the therapeutic tactics of patients. The article presents the main overview provisions of the formation of post- Covid-19 syndrome in individuals who have been infected with SARS-CoV-2. The reasons, symptoms and the most common syndromes that occur in patients after suffering a coronavirus infection are also given

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Zhdanova, E. V., E. V. Rubtsova, and E. G. Kostolomova. "Clinical and immunological characteristics of post-COVID syndrome." Bulletin of Siberian Medicine 23, no. 2 (2024): 46–54. http://dx.doi.org/10.20538/1682-0363-2024-2-46-54.

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Aim. To evaluate changes in clinical manifestations and the cytokine profile of blood serum in patients with postCOVID syndrome. Materials and methods. The study involved 46 patients (37 women and 9 men) with signs of post-COVID syndrome 1–12 months after COVID-19 infection. COVID-19 infection was laboratory-confirmed (patients were tested positive for SARS-Cov-2 RNA using polymerase chain reaction (PCR), or they were tested positive for SARS-Cov-2 immunoglobulin (Ig)G antibodies after the end of the acute phase and in asymptomatic infection). Along with mandatory tests included in the regular

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KARAKHALIS, L. Yu, A. R. JHIGALENKO, G. A. PENJHOYAN, and N. V. KOLESNIKOVA. "CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY." Kubanskij nauchnyj medicinskij vestnik, no. 5 (January 1, 2017): 37–44. http://dx.doi.org/10.25207/1608-6228-2017-24-5-37-44.

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Zhitnukhin, Yu L., I. V. Litvinenko, G. N. Bisaga, and M. M. Odinak. "Perfluorodecalin-induced changes in clinical and immunological parameters of experimental allergic encephalomyelitis." Bulletin of Experimental Biology and Medicine 123, no. 3 (1997): 273–75. http://dx.doi.org/10.1007/bf02445424.

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Sorokin, Yuriy Aleksandrovich. "Immunological features of chronic endometritis." Terapevt (General Physician), no. 1 (2022): 62–65. http://dx.doi.org/10.33920/med-12-2201-07.

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Chronic endometritis is a clinical and morphological syndrome with a complex of morphological and functional changes in the endometrium, leading to a violation of the physiological cyclic transformation and receptivity of endometrial tissues. The treatment of chronic endometritis requires special consideration. Despite the progress of pharmacotherapy, there are significant methodological and practical difficulties. Cavitated solutions, low-intensity ultrasound effects, and photochromotherapy increase the effectiveness of the treatment of chronic endometritis and female infertility.

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Dibrov, D. A. "ACCP-negative rheumatoid arthritis – clinical and immunological features." Rheumatology Science and Practice 60, no. 3 (2022): 314–26. http://dx.doi.org/10.47360/1995-4484-2022-314-326.

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Depending on the presence of laboratory biomarkers: rheumatoid factor IgM and anti-cyclic citrullinated peptide antibodies (ACCP), “seropositive” and “seronegative” variants of rheumatoid arthritis (RA) are distinguished. Immunological subtypes differ in risk factors, immunopathogenesis, and the course of the disease. A review of data concerning immunology and clinical features of ACCP-negative rheumatoid arthritis is presented. The presence of ACCP in the peripheral blood reflects the progressive erosive process with a predominance of the inflammatory component and involvement of the B cells.

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Chichirelo-Konstantynovych, K.D., L.V. Moroz, T.V. Konstantynovych, and A.V. Demchuk. "Immunological aspects of cytomegalovirus infection in community-acquired pneumonia among young adults." Medicni perspektivi 23, no. 1 part 1 (2018): 141–45. https://doi.org/10.26641/2307-0404.2018.1(part1).127253.

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The problem of comorbidities and mutual influence due to progressive immunological suppression occupies an important place in the morbidity structure among young population. This fact is usually considered to be a result of existent immunodeficiency in the process of studying respiratory comorbidities with subsequent chances of immunological reactivities. The purpose of our research is to investigate the features of immunological reactivity changes among young patients with community-acquired pneumonia and cytomegaloviral persistence. Received data showed a high level of cytomegaloviral persis

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Kulmukanova, K. K., A. U. Baiduissenova, E. A. Akhmediyarova, et al. "BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA." Medical Immunology (Russia) 23, no. 4 (2021): 781–84. http://dx.doi.org/10.15789/1563-0625-bir-2289.

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Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the

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Luz, Jean Carlos dos Santos da, Fernanda Antunes, Maria Alejandra Clavijo-Salomon, Emanuela Signori, Nayara Gusmão Tessarollo, and Bryan E. Strauss. "Clinical Applications and Immunological Aspects of Electroporation-Based Therapies." Vaccines 9, no. 7 (2021): 727. http://dx.doi.org/10.3390/vaccines9070727.

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Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunolo

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Sh.B., Pulatova, and Allamurodova N.A. "Renal problems in scleroderma: pathogenesis, clinical manifestations, and modern treatment methods." International Journal of Medical Sciences And Clinical Research 5, no. 3 (2025): 31–35. https://doi.org/10.37547/ijmscr/volume05issue03-06.

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Systemic sclerosis (SSc) is an autoimmune disease of connective tissue characterized by fibrosis of the skin and internal organs, vascular damage, and immunological changes. One of the most severe complications is renal involvement, particularly scleroderma renal crisis (SRC). Renal crisis is one of the most serious complications of SSc and often occurs in diffuse SSc. This article discusses the pathogenesis, clinical manifestations, diagnostic methods, and modern approaches to treatment of renal involvement in SSc.

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Kim, Jin Youp, Chae-Seo Rhee, Seong H. Cho, Goun Choe, Dong-Young Kim, and Doo Hee Han. "House Dust Mite Sublingual Immunotherapy in Children Versus Adults With Allergic Rhinitis." American Journal of Rhinology & Allergy 35, no. 1 (2020): 9–16. http://dx.doi.org/10.1177/1945892420931713.

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Background There are only a few studies in which the clinical efficacy of SLIT has been compared between children and adults. In addition, there is a lack of research on other factors, associated with the treatment, including immunological parameters and quality of life (QOL). Objective To compare the effects of sublingual immunotherapy (SLIT) in adults and children on various factors: clinical efficacy, quality of life (QOL), satisfaction, immunological parameters, and adverse events. Methods Subjects who were sensitized to house dust mites and treated with SLIT for at least 2 years were enro

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Borisova, O. "IMMUNOLOGICAL DIAGNOSTICS SYSTEMIC CONNECTIVE TISSUE DISEASES." Clinical Medicine and Pharmacology 6, no. 2 (2020): 25–39. http://dx.doi.org/10.12737/2409-3750-2020-6-2-25-39.

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Modern clinical immunology makes it possible to conduct fairly effective laboratory diagnostics of immuno-inflam-matory rheumatic diseases (IVRS). The applied methods make it possible to obtain objective information about the nature of immunopathological changes, being an important tool for diagnosis, assessment of activity, determining the prognosis, choosing a treatment method for the disease and monitoring the effectiveness of therapy. Currently, the optimal choice and use of immunological methods is possible. The main goal of laboratory diagnostics of IVRS is to obtain objective informatio

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Bröde, Peter, Maren Claus, Patrick D. Gajewski, Stephan Getzmann, Edmund Wascher, and Carsten Watzl. "From Immunosenescence to Aging Types—Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation." International Journal of Molecular Sciences 24, no. 17 (2023): 13186. http://dx.doi.org/10.3390/ijms241713186.

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Immunological aging type definition requires establishing reference intervals from the distribution of immunosenescence biomarkers conditional on age. For 1605 individuals (18–97 years), we determined the comprehensive immune age index IMMAX from flow-cytometry-based blood cell sub-populations and identified age-specific centiles by fitting generalized additive models for location, scale, and shape. The centiles were uncorrelated with age and facilitated the categorization of individuals as immunologically slow or fast aging types. Using its 50th percentile as a reference, we rescaled the IMMA

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Heo, Seung Chul, Jie-Eun Kim, and Rumi Shin. "Immunological changes during intraperitoneal growth of colorectal cancer." Journal of Clinical Oncology 36, no. 5_suppl (2018): 97. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.97.

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97 Background: Immunoediting other than PD-1 works in colorectal cancer (CRC), except for some MSI high tumors. Study of immune response to cancers in the primary CRC is difficult due to interference by the colonic microorganisms. If a clinical model reflecting tumor progression, free from microbial antigens and characterizing the microenvironment is developed it will help us understand the immunoediting of CRC. We studied immunologic changes, according to the peritoneal tumor progression, in ascites and peritoneal immune cells of CRC patients. These results will provide clues to the immunoedi

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Buyuktiryaki, Betul, Francesko Hela, Ayse Bilge Ozturk, et al. "Clinical features, severity, and immunological changes during venom immunotherapy in children and adults." Allergy and Asthma Proceedings 45, no. 4 (2024): 276–83. http://dx.doi.org/10.2500/aap.2024.45.240017.

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Background: Hymenoptera venom allergy (HVA) is among the most common causes of severe allergic reactions worldwide. Objective: To investigate clinical features and factors that affect the severity of HVA and to determine the alterations in immunologic biomarkers after venom immunotherapy (VIT). Methods: Seventy-six adults and 36 children were prospectively investigated. We analyzed specific immunoglobulin E (sIgE) and sIgG4 levels of venom extracts and components (rApi m1, rApi m10, rVes v1, rVes v5, rPol d5) before and after the first year of VIT. Results: Although cardiovascular symptoms wer

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Morais-Papini, Tatiane Figueiredo, Jordana Grazziela Alves Coelho-dos-Reis, Ana Paula Barbosa Wendling, et al. "Systemic Immunological changes in patients with distinct clinical outcomes during Mycobacterium tuberculosis infection." Immunobiology 222, no. 11 (2017): 1014–24. http://dx.doi.org/10.1016/j.imbio.2017.05.016.

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Castés, Marianella, Isabel Hagel, Miguel Palenque, Pablo Canelones, Alejandra Corao, and Neil R. Lynch. "Immunological Changes Associated with Clinical Improvement of Asthmatic Children Subjected to Psychosocial Intervention." Brain, Behavior, and Immunity 13, no. 1 (1999): 1–13. http://dx.doi.org/10.1006/brbi.1999.0551.

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Gulnora Kutpitdinovna Rakhmatullaeva, Firuza Khidoyatovna Inoyatova, Nigina Anorbekovna Vakhobova, and Akbarbek Anorbekovich Vakhobov. "Relationship between clinical and neuro-immunological parameters in post-COVID patients." World Journal of Advanced Research and Reviews 25, no. 3 (2025): 526–37. https://doi.org/10.30574/wjarr.2025.25.3.0753.

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The coronavirus infection continues to circulate among the population, which may lead to an increase in the number of patients with post-COVID neurological consequences. By studying the profiles of neurotropic autoantibodies, it is possible to diagnose the pathological process that began in the nervous tissue at the earliest stages of its development in post-COVID patients, which makes it possible to justify personalized neurotropic therapy, as well as predict the degree of reversibility of neurological disorders depending on their causation by a neurodestructive process or neurodysfunction. A

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Litvinenko, I. V., G. N. Bisaga, V. S. Chirsky, et al. "Balo's concentric sclerosis: a clinical case." Neurology, Neuropsychiatry, Psychosomatics 10, no. 3 (2018): 97–102. http://dx.doi.org/10.14412/2074-2711-2018-3-97-102.

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This paper describes a case of Balo's concentric sclerosis, a rare demyelinating disease of the central nervous system (CNS), which is currently classified as multiple sclerosis. In recent years, there has been a more favorable clinical course of Balo's sclerosis. The significant polymorphism of clinical manifestations of the disease, its neuroimaging pattern, and laboratory tests cause difficulties diagnosing this pathology. Its differentiation with CNS tumors presents a particular challenge. So it also happens in the described clinical case, when computed tomography revealed the signs of spa

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Moed, Heleen, Roy Gerth van Wijk, Rudi W. Hendriks, and J. C. van der Wouden. "Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite." Mediators of Inflammation 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/345217.

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Background. Allergic rhinitis is a disease with polarization towards Th2and a defect of regulatory T cells. Immunological changes have been reported after immunotherapy treatment. However, there is not much known about the natural course of allergic rhinitis with respect to clinical manifestation and the relation with immunological responses.Objective. To evaluate clinical symptoms of allergic rhinitis, in relation toin vivoallergen-specific skin responses andin vitroallergen-specific effector and regulatory T cells determined at baseline and after two years.Methods. From a large trial, 59 chi

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Shramko, S. V., L. F. Gulyaeva, V. N. Zorina, and T. V. Tretyakova. "Proliferative diseases of the uterus: clinical, immunological, and molecular aspects." Voprosy ginekologii, akušerstva i perinatologii 19, no. 5 (2020): 13–21. http://dx.doi.org/10.20953/1726-1678-2020-5-13-21.

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Objective. To perform comparative analysis of clinical data, serum levels of acute-phase proteins, cytokines, steroid hormones, and expression of genes encoding sex hormone receptors in tissues of patients with proliferative diseases of the uterus. Patients and methods. We analyzed clinical data of 349 patients with various proliferative diseases of the uterus. We also evaluated their serum levels of α2-macroglobulin, pregnancy-associated α2-glycoprotein, their immunocomplexes with IgG, lactoferrin, VEGF, IL-6, TNFa, IL-8, and sex hormones. Uterine tissue samples were tested for the expression

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Bieganowska, Katarzyna, Anna Członkowska, Andrzej Bidziński, Hanna Mierzewska, and Janina Korlak. "Immunological changes in the MPTP-induced Parkinson's disease mouse model." Journal of Neuroimmunology 42, no. 1 (1993): 33–37. http://dx.doi.org/10.1016/0165-5728(93)90209-h.

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Cztonkowska, A., K. Piotrowska, H. Mierzewska, and A. Bidziński. "Immunological changes in the MPTP induced parkinson disease mouse model." Journal of Neuroimmunology 35 (January 1991): 170. http://dx.doi.org/10.1016/0165-5728(91)91162-6.

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Gupta, Amita, and Jyoti Mathad. "Pulmonary Infections in Pregnancy." Seminars in Respiratory and Critical Care Medicine 38, no. 02 (2017): 174–84. http://dx.doi.org/10.1055/s-0037-1602375.

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AbstractPregnant women experience physiological and immunological changes that increase the risk or severity of certain pulmonary infections. These changes also affect drug disposition, which impacts treatment choices. In this article, we review the available data on (1) the physiological and immunological changes that specifically impact tuberculosis, influenza, and varicella pneumonia; (2) active and latent tuberculosis management, including drug monitoring and maternal–infant outcomes; (3) the treatment and prevention of influenza; and (4) the diagnosis and management of varicella pneumonia

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Seo, Joo Hee, Yun-Jin Lee, Ki Hyeong Lee, Elakkat Gireesh, Holly Skinner, and Michael Westerveld. "Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum." Clinical and Experimental Pediatrics 63, no. 8 (2020): 291–300. http://dx.doi.org/10.3345/kjp.2019.00598.

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Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron-specific autoantibodies targeting intracellular and plasma membrane antigens. However, current criteria for autoimmune encephalitis are quite dependent on antibody testing and responses to immunotherapy, which might delay the diagnosis. This form of encephalitis can involve the multifaceted present

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