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Journal articles on the topic 'Colon Cancer Early Colon Cancer Early Cancer Colon Cancer Screening Colonoscopy'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Flynn, Duncan J., and Joseph D. Feuerstein. "Colon cancer screening programs prevent cancer." World Journal of Gastroenterology 30, no. 42 (2024): 4566–68. http://dx.doi.org/10.3748/wjg.v30.i42.4566.

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In this article we comment on the article by Agatsuma et al . Our article focuses on the use of screening for colon cancer increases the likelihood of early diagnosis of colorectal cancer compared to those presenting after symptoms develop. Patients with symptoms were more likely to have left-sided lesions with resultant hematochezia and/or changes in bowel habits. In this study almost all patients in the screen group were first screened with immunochemical fecal occult blood testing. Colonoscopy was used either if it was thought to be the more appropriate initial screening modality or if the

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Noor, Ali Alqallaf Albalawi Ghada Saleh H. Amal Mohammed Abdu Shahad Hani Almuntaser Saud Abdulmajeed Bin Rakhis Abdulmalik Abdulaziz Almughamis Abdullah Abdulrahman Ghanim Ahmed Saeed Alkhathami Nourah Ali Aldossari Ghaida Mohammad Ahmad. "COLON CANCER SCREENING AND PREVENTION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 13071–78. https://doi.org/10.5281/zenodo.1495157.

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<strong><em>Introduction:</em></strong><em> Colorectal cancer (CRC) is considered one of the most common cancers around the world, it is the second most common in women, and the third in men worldwide<sup>1</sup>.CRC constitutes for about 10% of all cancers around the world with about 1.36 million people affected around the world, accounting for nearly 10% of cancers<sup>2</sup>. It is the second leading cause of mortality due to cancer both in the United States and worldwide <sup>3</sup>. CRC have a significantly slow rate of progression. Due to this slow progression and the relatively easy d

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Freeman, Hugh James. "Long-Term Follow-Up of Patients with Malignant Pedunculated Colon Polyps after Colonoscopic Polypectomy." Canadian Journal of Gastroenterology 27, no. 1 (2013): 20–24. http://dx.doi.org/10.1155/2013/380389.

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BACKGROUND: Previously published studies have suggested that patients with resected colon cancer have an increased risk for early metachronous colon cancer. Current screening guidelines recommend intense surveillance by colonoscopy for the initial five years after the initial colon cancer has been resected. Information regarding endoscopically removed malignant polyps is limited.METHODS: In the present study, 25 consecutive patients (14 male, 11 female) with malignant pedunculated colon polyps treated with snare cautery polypectomy were followed for more than one decade up to 20 years. Five pa

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Jovandaric, Miljana Z. "Importance of diet and intestinal microbiota in the prevention of colorectal cancer - colonoscopy early screening diagnosis." World Journal of Gastrointestinal Oncology 16, no. 8 (2024): 3428–35. http://dx.doi.org/10.4251/wjgo.v16.i8.3428.

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Colorectal cancer is a term used to describe colon and rectal cancer, which is the third most common type of cancer. A MEDLINE and PubMed search resulted in the inclusion of manuscripts written in the last 10 years, using keywords relevant to the topic of the manuscript. By analyzing the aim of the searched studies and manuscripts, adequate articles were included that described the stated problem. The frequency of colorectal cancer varies with climate, nutrition, and many other factors, primarily endogenous, hereditary, intestinal microbiome, as well as external factors, such as exposure of th

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Gordon, Murray B., Samer Nakhle, and William H. Ludlam. "Patients with Acromegaly Presenting with Colon Cancer: A Case Series." Case Reports in Endocrinology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5156295.

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Introduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). Case 1 patient was a 36-year-old male with acromegaly who underwent transsphenoidal surgery to remove the pituitary adenoma. After surgery, the patient underwent routine colonoscopy screening, which revealed a 40 mm tubular adenoma in the descending colon.

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Elhossary, Marwa, Nehah Hawash, Rehab Badawi, et al. "Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer." Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 19, no. 3 (2020): 302–12. http://dx.doi.org/10.2174/1871523018666190625164100.

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Background: Effective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination. Aim: The aim of the study was a comparative evaluation of chromocolonoscopy and Colon Cancer-Specific Antigen-2 test for early detection of colorectal cancer in Egyptian patients. Methods: This case control study was carried out on 55 patients classified into 3 groups: Group I consisted of twenty patients with precancerous lesions detected by colonoscopy, Group II consi

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Smith, Andrew P., Yanek S. Y. Chiu, and Nancy M. Lee. "Towards Universal Screening for Colon Cancer: A Cheap, Reliable, Noninvasive Test Using Gene Expression Analysis of Rectal Swabs." ISRN Gastroenterology 2012 (January 29, 2012): 1–8. http://dx.doi.org/10.5402/2012/170210.

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Though colon cancer is the second leading cause of cancer deaths in the US, it is entirely preventable through early screening to detect and remove adenomatous polyps. Colonoscopy has long been regarded as the “gold standard” but is expensive, invasive, and uncomfortable, and only about half those considered at risk for colon cancer currently submit to colonoscopy or to less reliable alternatives such as fecal occult blood test. Here we describe the use of gene expression analysis to detect altered expression of certain genes associated with not only colon cancer but also polyps. The analysis

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Saleh, Abdulrahman Abdulatif. "ROLES OF COLONOSCOPY IN EARLY DETECTION OF COLORECTAL CANCER AND REVIEWING RISK FACTORS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 15068–76. https://doi.org/10.5281/zenodo.3374920.

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<em>Colorectal cancer (CRC) is a common and lethal disease. The danger of obtaining CRC is affected by both ecological and genetic factors, which are discussed in this review. The epidemiology of CRC and Colorectal screening, pros and effect of Colonoscopy are emphasized as well. </em><em>We conducted a narrative review study that performed through Comprehensive literature search was performed in MEDLINE/PubMed (using combinations of the following search terms: " colorectal cancer, Colonoscopy, diagnosis, screening, risk factors" " our search was ended on June, 2019. Numerous co

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Azer. "Challenges Facing the Detection of Colonic Polyps: What Can Deep Learning Do?" Medicina 55, no. 8 (2019): 473. http://dx.doi.org/10.3390/medicina55080473.

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Colorectal cancer (CRC) is one of the most common causes of cancer mortality in the world. The incidence is related to increases with age and western dietary habits. Early detection through screening by colonoscopy has been proven to effectively reduce disease-related mortality. Currently, it is generally accepted that most colorectal cancers originate from adenomas. This is known as the “adenoma–carcinoma sequence”, and several studies have shown that early detection and removal of adenomas can effectively prevent the development of colorectal cancer. The other two pathways for CRC developmen

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Haridharshini K S and Dr. A. Manimaran. "Developing a Machine Learning Model for Colon Cancer Detection from Colonoscopy Data." International Journal of Scientific Research in Science and Technology 12, no. 4 (2025): 12–21. https://doi.org/10.32628/ijsrst251243.

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Colon cancer is one of the leading causes of cancer- related deaths globally. Early detection and accurate diagnosis are crucial for improving patient outcomes and survival rates. Colonoscopy remains the gold standard for detecting colon cancer,yet the process is highly dependent on the expertise of the physician and can be time-consuming. In this project, we aim to develop an automated machine learning model for the detection of colon cancer from colonoscopy images and videos. We explore various machine learning techniques, including Con- volutional Neural Networks (CNNs), to analyze colonosc

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Volkov, S. V., and S. L. Lobanov. "Characterization of the parietal intestinal microbiota in colon cancer." Сибирский научный медицинский журнал 41, no. 2 (2021): 74–78. http://dx.doi.org/10.18699/ssmj20210210.

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Introduction. Colon cancer (RCC) clinically manifests itself in the late stages, therefore, early diagnosis presents significant difficulties. There are many types of microorganisms in the human colon that form symbiosis with intestinal cells to maintain normal function. Аim of the study was to determine the composition of the parietal microflora of the colon under conditions of a tumor process and to assess the possibility of using these data in the diagnosis of colon cancer. Material and methods. The main group included 63 patients operated on for cancer (adenocarcinoma) of the left half of

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Synytsya, Alla, Aneta Vaňková, Michaela Miškovičová, Jaromír Petrtýl, and Luboš Petruželka. "Ex Vivo Vibration Spectroscopic Analysis of Colorectal Polyps for the Early Diagnosis of Colorectal Carcinoma." Diagnostics 11, no. 11 (2021): 2048. http://dx.doi.org/10.3390/diagnostics11112048.

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Colorectal cancer is one of the most common and often fatal cancers in humans, but it has the highest chance of a cure if detected at an early precancerous stage. Carcinogenesis in the colon begins as an uncontrolled growth forming polyps. Some of these polyps can finally be converted to colon cancer. Early diagnosis of adenomatous polyps is the main approach for screening and preventing colorectal cancer, and vibration spectroscopy can be used for this purpose. This work is focused on evaluating FTIR and Raman spectroscopy as a tool in the ex vivo analysis of colorectal polyps, which could be

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Alshammari, Mohammed, Saleh Al-Maktoum, Abdulrahman Alsharidah, et al. "An Assessment of Knowledge, Attitude, and Practice (KAP) of Colorectal Cancer among Community Pharmacists in the Qassim Region of Saudi Arabia." Pharmacy 12, no. 2 (2024): 42. http://dx.doi.org/10.3390/pharmacy12020042.

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Background: The global burden of colorectal cancer remains a major public health issue and one of the leading causes of death worldwide. In Saudi Arabia, it continues to be a health concern. Any delays in diagnosis for any reason may contribute to advanced complications; therefore, pharmacists’ knowledge and awareness of colorectal cancer are crucial for the welfare of society. Studies of colon cancer-related knowledge, attitude, and practice (KAP) among community pharmacists have not previously been conducted in the Al-Qassim region of Saudi Arabia. In the present study, therefore, we sought

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Kavitha, Muthu Subash, Prakash Gangadaran, Aurelia Jackson, Balu Alagar Venmathi Maran, Takio Kurita, and Byeong-Cheol Ahn. "Deep Neural Network Models for Colon Cancer Screening." Cancers 14, no. 15 (2022): 3707. http://dx.doi.org/10.3390/cancers14153707.

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Early detection of colorectal cancer can significantly facilitate clinicians’ decision-making and reduce their workload. This can be achieved using automatic systems with endoscopic and histological images. Recently, the success of deep learning has motivated the development of image- and video-based polyp identification and segmentation. Currently, most diagnostic colonoscopy rooms utilize artificial intelligence methods that are considered to perform well in predicting invasive cancer. Convolutional neural network-based architectures, together with image patches and preprocesses are often wi

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Bellows, Charles, Giuseppe Gagliardi, and Lorenzo Bacigalupo. "Review of Computed Tomographic Colonography from a Surgeon’s Perspective." Journal of Gastrointestinal and Liver Diseases 24, no. 2 (2015): 215–23. http://dx.doi.org/10.15403/jgld.2014.1121.242.blws.

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Abstract New research has addressed many of the early concerns of Computed Tomographic colonography (CTC) and these studies are now beginning to shape clinical practices. A review of the literature demonstrates that the sensitivity of CTC in screening for large polyps (≥ 1cm) or cancers in the large intestine is as high as that of conventional optical colonoscopy, however, the sensitivity decreases with the diameter of the polyp. Despite this, CTC is well tolerated, more acceptable to patients than optical colonoscopy and therefore may improve colorectal cancer screening compliance. This

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Sun, Na. "The Relationship Between Technology Use and Colon Cancer Screening." Innovation in Aging 4, Supplement_1 (2020): 317. http://dx.doi.org/10.1093/geroni/igaa057.1014.

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Abstract Population aging is accompanied by an increase in chronic diseases such as cancer. Colon cancer is the third most common cancer and a leading cause of cancer death. Screening tests can aid early detection and treatment. It is unclear how information and communication technology (ICT), especially media through mobile devices, influences cancer screening. This study analyzes the relationship between ICT usage and colon cancer screening among U.S. adults. Data are from the second cycle of the Health Information National Trend Survey 5. Cancer screening included having one of the followin

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Mentor-Marcel, R. A., K. Visvanathan, M. A. Garza, Y. Xie, L. McCaffrey, and J. G. Ford. "Predictors of colon cancer screening among low-income urban minority residents: The Cancer Risk Assessment in Baltimore (CRAB) Study." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4101. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4101.

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4101 Background: Colorectal cancer mortality can be reduced through early detection, using recommended screening tests (fecal occult blood test (FOBT), sigmoidoscopy, or colonoscopy). However, screening is underutilized, especially among low-income and racial/ethnic minority groups. Few studies have examined determinants of screening in these groups. Methods: We analyzed data on predictors of colon cancer screening from a cross-sectional study of Baltimore City Residents (N = 534). Participants responded to a questionnaire administered by an interviewer, on screening practices, behavioral, soc

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Fort, Callie, Chaitra Surapaneni, and Rakesh Surapaneni. "Risk of second cancers in long term survivors of neuroendocrine tumors of the large intestine." Journal of Clinical Oncology 42, no. 3_suppl (2024): 600. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.600.

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600 Background: There is an increasing incidence of neuroendocrine tumors (NET) of the colon and rectum likely related to increased screening colonoscopy and availability of better diagnostics. Most of these tumors identified during screening are low grade early-stage tumors with high cure rates. Data on long term risk of recurrence of NET and other second cancers is lacking. We studied the incidence rates of all second malignancies in survivors of NET of the colon and rectum. Methods: We analyzed data from the Surveillance, Epidemiology and End Results (SEER), Research Data 17 Registries, Nov

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Haggitt, Rodger C. "Premalignant Lesions of the Colon." Canadian Journal of Gastroenterology 4, no. 4 (1990): 174–78. http://dx.doi.org/10.1155/1990/857961.

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Cancer of the colon and rectum is the second most common cancer in men and women in North America. Early diagnosis results in detection of early stage tumours with a high probability of cure. Several studies document the efficacy of screening for the early detection of colorectal cancer; however, its incidence is so high chat screening the entire older adult population is not feasible. Thus, attempts have been made to focus screening on patients at higher than average risk for colorectal carcinoma; these include patients with predisposing conditions or premalignant lesions of the colon. Common

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Gini, Andrea, Reinier G. S. Meester, Homa Keshavarz, et al. "Cost-Effectiveness of Colonoscopy-Based Colorectal Cancer Screening in Childhood Cancer Survivors." JNCI: Journal of the National Cancer Institute 111, no. 11 (2019): 1161–69. http://dx.doi.org/10.1093/jnci/djz060.

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Abstract Background Childhood cancer survivors (CCS) are at increased risk of developing colorectal cancer (CRC) compared to the general population, especially those previously exposed to abdominal or pelvic radiation therapy (APRT). However, the benefits and costs of CRC screening in CCS are unclear. In this study, we evaluated the cost-effectiveness of early-initiated colonoscopy screening in CCS. Methods We adjusted a previously validated model of CRC screening in the US population (MISCAN-Colon) to reflect CRC and other-cause mortality risk in CCS. We evaluated 91 colonoscopy screening str

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Emiloju, Oluwadunni Eunice, Bahar Saberzadeh Ardestani, and Frank A. Sinicrope. "Comparison of precursor neoplasms at colonoscopic diagnosis of early-onset and later-onset colon cancer." Journal of Clinical Oncology 41, no. 4_suppl (2023): 74. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.74.

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74 Background: Colorectal cancer (CRC) incidence has steadily increased in adults younger than 50 years (EO-CRC) since the 1990s, with a reported higher prevalence in the left colon and rectum. Established precursor lesions of CRCs are adenomas, including advanced adenomas, and sessile serrated polyps. We hypothesized that patients at diagnosis of early-onset colon cancer (EO-CC) would have fewer adenomas compared to patients with later-onset colon cancer (LO-CC). Methods: We performed a retrospective review of electronic health records and identified 58 patients diagnosed with EO-CC who had c

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Dan-Nicolae, Bele. "The Value of Colon Cancer Screening in Developing Countries." American Journal of Clinical Case Reports 4, no. 1 (2023): 03–04. http://dx.doi.org/10.33597/2766-5844-v4-id1074.

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Abstract Objectives: Colorectal cancer is the third most diagnosed cancer worldwide and the second most common cause of cancer death. If diagnosed at an early stage, however, it is one of the most curable malignancies. Patients with biopsy-proven adenocarcinoma of the colon without evidence of distant metastasis, and without contraindications to major surgery, are commonly treated with surgical resection. Methods and results: A 49-year-old male patient without any significant history is admitted at Surgery 5 Service, Cluj-Napoca for abdominal pain, diarrhoea, and important weight loss in the l

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Ahmed, Farid E., Farid E. Ahmed, Farid E. Ahmed, et al. "Quantification of Micrornas by Absolute Dpcr for the Diagnostic Screening of Colon Cancer." Journal Of Colon And Rectal Cancer 1, no. 3 (2019): 10–37. http://dx.doi.org/10.14302/issn.2471-7061.jcrc-18-2526.

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There is currently no validated micro(mi)RNA diagnostic stool test to screen for colon cancer (CC) on the market because of the complexity of fecal density, vulnerability of stool to daily changes, and the presence of three sources of miRNAs in stool (cell-free from fecal homogenates, exsosomal miRNAs from fecal exosomes, and fecal colonocytes). To address these complexities, we have first carried out a microarray miRNA experiment, using Affymetrix GeneChip miRNA 2.0 Arrays, on immunocaptured and enriched stool colonocytes of 15 subjects (three healthy controls and twelve colon cancer patients

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Pineau, Benoit C. "Motion-Computerized Tomographic Colography is a Better Method for Screening for Polyps: Arguments for the Motion." Canadian Journal of Gastroenterology 17, no. 2 (2003): 125–28. http://dx.doi.org/10.1155/2003/210940.

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Colorectal cancer is an important public health problem that is amenable to prevention and early treatment. Traditional screening techniques - fecal occult blood testing, flexible sigmoidoscopy, barium enema and colonoscopy - each have limitations in terms of diagnostic accuracy, cost and/or patient acceptability. Compliance with recommendations for screening has been poor, in part, because of negative perceptions about the available modalities. Virtual colonoscopy, or computerized tomographic colography, is a minimally invasive technique that safely evaluates the entire colon and does not req

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Belev, Nicodim F., Rodica Mindruta-Stratan, Diana Iarovoi, Tatiana Kazubskaya, and Diana Brega. "Risk of colorectal cancer and endoscopic screening in families of patients with hereditary nonpolyposis syndrome of colorectal cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): e12543-e12543. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e12543.

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e12543 Background: Relatives of patients with hereditary nonpolyposis colorectal cancer (HNPCC) have an elevated risk of colorectal cancer (CRC) and adenomas. To determine the efficacy of endoscopic screening among relatives of patients with HNPCC syndrome. Methods: 50 relatives of the first and 17 relatives of the second-degree relatives of 127 families of patients with HNPCC syndrome was subjected to endoscopic screening (colonoscopy). Results: The analysis of cancer register database of families, which includes clinical and genealogical information about 1,505 patients with colorectal cance

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Luka, J., P. M. Arlen, and J. A. Bristol. "Development of a new stool biomarker ELISA for the early detection of colorectal cancer." Journal of Clinical Oncology 29, no. 4_suppl (2011): 390. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.390.

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390 Background: An ELISA was developed using NPC-1C, a novel antibody that reacts with an antigen expressed specifically by human colorectal and pancreatic tumor tissues and cell lines. The target antigen that NPC-1C recognizes was shown to be related to MUC5AC, a member of the mucin family of glycoproteins. NPC-1C reacts with neither normal tissues from healthy donors (rare, weak binding to normal colon and esophagus), nor cell lines derived from other tumor types, thereby providing the basis for a proof of concept comparative evaluation with stool from normal healthy donors. Methods: An ELIS

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Bankovic-Lazarevic, Dusica, Zoran Krivokapic, Goran Barisic, Verica Jovanovic, Dragan Ilic, and Marko Veljkovic. "Organized colorectal cancer screening in Serbia - the first round within 2013-2014." Vojnosanitetski pregled 73, no. 4 (2016): 360–67. http://dx.doi.org/10.2298/vsp150421113b.

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Background/Aim. The National Organized Colorectal Cancer Screening Program was conducted in the Republic of Serbia during 2013-2014 covering the population of both genders, aged 50 to 74 years, in 28 municipalities out of 180, with the target population of 651,445 people. This organized colorectal cancer screening aims to reduce mortality from colorectal cancer in the target population. The aim of this study was to show the results of organized screening for colorectal cancer during the first biannual round in Serbia. Methods. General practitioners from the primary health centers, invited targ

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Vilkoite, Ilona, Ivars Tolmanis, Hosams Abu Meri, Inese Polaka, Linda Mezmale, and Aivars Lejnieks. "Age-Based Comparative Analysis of Colorectal Cancer Colonoscopy Screening Findings." Medicina 59, no. 11 (2023): 2017. http://dx.doi.org/10.3390/medicina59112017.

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Background and Objectives: Colorectal cancer (CRC) incidence is rapidly emerging among individuals <50 years, termed as early-onset colorectal cancer (EOCRC). This study aimed to probe variations in tumorigenic pathology and relevant manifestations (polyp and adenoma incidence) between suspected cases of EOCRC and late-onset CRC (LOCRC; ≥50 years of age). Materials and Methods: Between September 2022 and February 2023, colonoscopy-based screening data from 1653 patients were included in this study. All eligible participants were divided into two groups, depending upon patient age, where Gro

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Nesterov, P. V., A. V. Ukharskiy, and N. V. Kislov. "Regional clinical and economic model of colorectal cancer screening." Research and Practical Medicine Journal 7, no. 3 (2020): 146–59. http://dx.doi.org/10.17709/2409-2231-2020-7-3-15.

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Purpose of the study. To evaluate the clinical and economic efficiency of colorectal cancer screening model in the Yaroslavl region. Materials and methods. To achieve this goal, we have given a clinical and economic assessment of the existing approach to the diagnosis and treatment of colon cancer. We have also developed a clinical and economic model of colorectal cancer screening strategy in the Yaroslavl region. After that, we made a comparative assessment between the strategies on such parameters as total costs, efficiency, and CER coefficient. Results. The strategy for the absence of color

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McLeod, Robin S. "Screening Strategies for Colorectal Cancer: A Systematic Review of the Evidence." Canadian Journal of Gastroenterology 15, no. 10 (2001): 647–60. http://dx.doi.org/10.1155/2001/284746.

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BACKGROUND: Colorectal cancer is the third most common cancer in Canada. It is well recognized that there are improved survival rates if the disease is treated in its early stages, and indeed this may be a preventable disease. This paper systematically reviews the effectiveness of specific screening techniques for colorectal cancer in asymptomatic individuals at normal or above average risk.METHODS: MEDLINE was searched for articles published between January 1966 and January 2001 by using the MESH terms 'screening' and 'colorectal neoplasia'. The reference sections of review articles published

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Chen, Yen T., Heather A. Becker, Gabriela Orsak, Carlton M. Allen, and Paul McGaha. "Predictors of Colorectal Cancer Screening Activities among Uninsured Individuals in Rural Northeast Texas." Texas Public Health Journal 72, no. 2 (2020): 13–17. https://doi.org/10.5281/zenodo.6476004.

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Introduction: Adherence to colorectal cancer (CRC) screening recommendations allows for both prevention and early detection of the disease, yet approximately one-third of U.S. adults aged 50-75 years have not regularly received CRC screening. Screening rates are lower for uninsured and rural individuals. We examined the relationships between demographic factors, past CRC screening experience, family history of colon cancer, and preference for CRC screening (fecal immunochemical test [FIT] vs. colonoscopy) and completion of CRC screening in an ethnically diverse, largely rural sample, with a sp

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Trushina, Olga Yu, Maria A. Isaikina, Ksenia A. Vekhova, Polina I. Lazareva, Renat A. Takhirov, and Viсtor V. Fomin. "Colonoscopy: History, development and prospects." Terapevticheskii arkhiv 97, no. 04 (2025): 393–96. https://doi.org/10.26442/00403660.2025.04.203156.

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The article highlights the stages of formation and development of colonoscopy from simple rectal examinations to modern video endoscopy. The development of imaging technologies has improved the early diagnosis and verification of colorectal cancer and inflammatory bowel disease, screening of colon tumors. Moreover, it was made possible to carry out minimally invasive interventions – taking a biopsy and performing a polypectomy. The prospects of the method and its place in clinical practice are discussed.

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Bagga, Ekta, David Innes, and Edmund Leung. "Looking beyond the surface: Muir Torre syndrome." Archive of Clinical Cases 10, no. 3 (2023): 119–22. http://dx.doi.org/10.22551/2023.40.1003.10255.

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Muir-Torre Syndrome (MTS) is associated with multiple visceral malignancies. Initial presentation may be a benign skin tumor mimicking a sebaceous cyst. This case report highlights the importance of early diagnosis, genetic testing, and multidisciplinary screening. A 67-year-old man was diagnosed with MTS following excision of a skin lesion (sebaceoma). He was declined both screening colonoscopy and genetic testing. Subsequently, advanced colon cancer was found following presentation with iron deficiency anemia, which ultimately led to palliation despite successful surgery. MTS can present ins

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Foreman, Leslie, Donna Akerson Green, Beverly Thorpe, et al. "A demonstration project: Providing colon cancer screening to homeless people—Capitalizing on community partnerships." Journal of Clinical Oncology 35, no. 15_suppl (2017): e18009-e18009. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e18009.

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e18009 Background: Homeless people encounter many barriers to healthcare and preventative services, while having an increased prevalence of most risk factors for cancer. A group of homeless adults (40) receiving services from Preble Street in Portland Maine were successfully provided access, support and coaching to participate in colon cancer screening using Fecal Immunochemical Test (FIT) over a period of six weeks. Maine Medical Center Cancer Institute (MMCCI) recruited a Physician champion, while Preble Street gathered multiple internal and external community partners and together help plan

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He, Yupeng, Anton Valouev, Liyang Xiong, et al. "Abstract 3331: Highly sensitive blood-based multi-cancer screening device with tiered specificity based on diagnostic workflow." Cancer Research 83, no. 7_Supplement (2023): 3331. http://dx.doi.org/10.1158/1538-7445.am2023-3331.

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Abstract Background. Multi-cancer blood-based tests may yield clinical benefit by improving compliance to guideline recommended screening with a more patient-friendly modality, and also by detection of early (stage I/II) tumors in cancer types that lack screening tests, yet early intervention can save lives. A single test with clinically meaningful performance which addresses both opportunities has yet to be developed. Methods. We evaluated a blood-based multi-modal device based on cfDNA epigenomic and targeted protein analysis that enables high performance for early-stage cancer detection in

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RKR, Vedula. "Role of CT colonoscopy for colorectal cancer screening in Indian population." Journal of Medical and Scientific Research 4, no. 3 (2016): 136–46. http://dx.doi.org/10.17727/jmsr.2016/4-031.

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Cancer as a cause of death is missed mostly in many parts of India. Mortality continues to rise from colorectal cancers that could well be prevented. Genetic, familial and dietary factors significantly account for increased risk of colorectal cancers. More so, large bowel origin of cancer, as a primary lesion or a source of distant metastases is undetected in a large number of patients in the absence of a complete work up. Even with metastatic disease, patients with colorectal cancer survive for many years unlike those having upper gastrointestinal cancers. Colorectal malignancy is potentially

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Martinez, Carlos Augusto Real, Lilian Vital Pinheiro, Debora Helena Rossi, et al. "Adenocarcinoma of the Right Colon in a Patient with Bloom Syndrome." Case Reports in Surgery 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/3176842.

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Introduction. Bloom syndrome (BS) is an inherited disorder due to mutation inBLMgene. The diagnosis of BS should be considered in patients with growth retardation of prenatal onset, a photosensitive rash in a butterfly distribution over the cheeks, and an increased risk of cancer at an early age. Clinical manifestations also include short stature, dolichocephaly, prominent ears, micrognathia, malar hypoplasia and a high-pitched voice, immunodeficiency, type II diabetes, and hypogonadism associated with male infertility and female subfertility. The aim of this report is to describe case of pati

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Dwivedi, Alok K., Sherif E. Elhanafi, Mohamed O. Othman, and Marc J. Zuckerman. "Zero-inflated models for the evaluation of colorectal polyps in colon cancer screening studies—a value-based biostatistics practice." PeerJ 13 (May 26, 2025): e19504. https://doi.org/10.7717/peerj.19504.

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Background Colon cancer screening studies are needed for the early detection of colorectal polyps to reduce the risk of colorectal cancer. Unfortunately, the data generated on colon polyps are typically analyzed in their dichotomized form and sometimes with standard count models, which leads to potentially inaccurate findings in research studies. A more appropriate approach for evaluating colon polyps is zero-inflated models, considering undetected existing polyps at colonoscopy screening. Method We demonstrated the application of the zero-inflated and hurdle models including zero-inflated Poi

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Aldakhil, Mohammed D., Abdullah S. Alayaaf, Nibras M. Alamro, and Omar K. Aljubaili. "Awareness of colon cancer screening among the general population: Community-based study from the Qassim Region of Saudi Arabia." Journal of Family Medicine and Primary Care 13, no. 11 (2024): 5207–12. http://dx.doi.org/10.4103/jfmpc.jfmpc_865_24.

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ABSTRACT Introduction: Colorectal cancer (CRC) has surged to prominence as the leading cancer affecting men and the second most common affecting women in Saudi Arabia. The need for preventative screening is underscored by the rising prevalence of precancerous polyps, early-stage colorectal cancer, and the fact that these conditions often manifest without symptoms. Methods: This study utilized a cross-sectional descriptive design and employed data from a sample of 425 residents of Qassim region in Saudi Arabia. The participants guaranteed their confidentiality when completing self-administered

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Campos, Frederico Fonseca, and Renata Luiza de Medeiros Rodrigues Scocuglia. "RASTREAMENTO DE LESÕES NEOPLÁSICAS EM CÓLON DIREITO POR COLONOSCOPIA: UM ESTUDO RANDOMIZADO E CONTROLADO DE COLONOSCOPIA CONVENCIONAL VERSUS CROMOSCOPIA COM ÍNDIGO CARMIM E DIGITAL." Revista ft 29, no. 142 (2025): 38–39. https://doi.org/10.69849/revistaft/ar10202501101038.

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The study of colorectal neoplastic lesions, particularly adenomatous ones, is relevant due to their association with colorectal carcinoma (CRC), the fourth leading cause of cancer in Brazil. Screening aims to detect premalignant lesions or early-stage cancer, reducing disease progression through endoscopic resection. This research evaluated the detection rate of colorectal neoplastic lesions in conventional colonoscopy compared to digital chromoendoscopy methods (FICE) and indigo carmine in the right colon. A total of 309 patients underwent screening between September 2017 and May 2018, divide

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Kanthan, Rani, Jenna-Lynn Senger, and Selliah Chandra Kanthan. "Fecal Molecular Markers for Colorectal Cancer Screening." Gastroenterology Research and Practice 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/184343.

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Despite multiple screening techniques, including colonoscopy, flexible sigmoidoscopy, radiological imaging, and fecal occult blood testing, colorectal cancer remains a leading cause of death. As these techniques improve, their sensitivity to detect malignant lesions is increasing; however, detection of precursor lesions remains problematic and has generated a lack of general acceptance for their widespread usage. Early detection by an accurate, noninvasive, cost-effective, simple-to-use screening technique is central to decreasing the incidence and mortality of this disease. Recent advances in

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Novikova, Valeriya P., and Alexey N. Drygin. "Fecal blood tests-screening methods for identification of pre-tumor changes and tumors at the early stage." Pediatrician (St. Petersburg) 10, no. 5 (2020): 73–78. http://dx.doi.org/10.17816/ped10573-78.

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Mortality due to cancer of the rectal colon is currently increasing in all groups of the adult population. Various screening methods are used to identify the pre-tumor and early stages of the development of tumor pathology of the colon: occult blood tests in feces, computer colonography (virtual colonoscopy), colonoscopy, DNA testing, tumor marker M2-PK (tumor fractional pyruvate kinase fraction M2). All of these colorectal cancer screening methods give good results, but there is no consensus among experts regarding the choice of the most optimal method. One of the first tests to detect hidden

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Ramsoekh, D., M. E. van Leerdam, M. van Ballegooijen, J. D. F. Habbema, and E. J. Kuipers. "Population Screening for Colorectal Cancer: Faeces, Endoscopes or X-Rays?" Analytical Cellular Pathology 29, no. 3 (2007): 185–94. http://dx.doi.org/10.1155/2007/610496.

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Colorectal carcinoma (CRC) is a common cancer and the second most common cause of death. The therapeutic costs for this disease will continue to rise due to an increasing incidence and the introduction of new chemotherapeutic modalities. Colorectal carcinoma is preceded by precursor lesions, which can be used as a target for early detection and therapy. Biennial population screening with faecal occult blood tests (FOBT) lowers CRC mortality with 14–18%. Five year screening with flexible sigmoidoscopy is a cost-effective alternative, which yields a higher preventive effect when similar particip

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Hunter, Ewan, Heba Alshaker, Cicely Weston, et al. "A New Blood-Based Epigenetic Diagnostic Biomarker Test (EpiSwitch®® NST) with High Sensitivity and Positive Predictive Value for Colorectal Cancer and Precancerous Polyps." Cancers 17, no. 3 (2025): 521. https://doi.org/10.3390/cancers17030521.

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Background/Objectives: Colorectal cancer (CRC) arises from the epithelial lining of the colon or rectum, often following a progression from benign adenomatous polyps to malignant carcinoma. Screening modalities such as colonoscopy, faecal immunochemical tests (FIT), and FIT-DNA are critical for early detection and prevention, but non-invasive methods lack sensitivity to polyps and early CRC. Chromosome conformations (CCs) are potent epigenetic regulators of gene expression. We have previously developed an epigenetic assay, EpiSwitch®®, that employs an algorithmic-based CCs analysis. Using EpiS

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Shen, Liping, Wenqing Lu, Yujv Huang, et al. "SNORD15B and SNORA5C: Novel Diagnostic and Prognostic Biomarkers for Colorectal Cancer." BioMed Research International 2022 (May 9, 2022): 1–10. http://dx.doi.org/10.1155/2022/8260800.

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Colorectal cancer (CRC) is presenting a global public health problem with high incidence and mortality. Early diagnosis and treatment are the most important strategies to improve prognosis of this disease. Besides fecal occult blood test (FOBT) and colonoscopy, the most widely used methods for CRC screening currently, more effective methods for early diagnosis or prognostic prediction for CRC are needed. Small nucleolar RNAs (snoRNAs) is a class of noncoding RNAs (ncRNAs) playing crucial roles in carcinogenesis and considered to be promising tumor biomarker. In this study, we found that SNORD1

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Starker, Anne, Franziska Prütz, and Susanne Jordan. "Intention for Screening Colonoscopy among Previous Non-Participants: Results of a Representative Cross-Sectional Study in Germany." International Journal of Environmental Research and Public Health 18, no. 8 (2021): 4160. http://dx.doi.org/10.3390/ijerph18084160.

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Early detection of colorectal cancer has the potential to reduce mortality at population level. Colonoscopy is the preferred modality for colon cancer screening and prevention, but attendance rates are low. To exploit colonoscopy’s preventive potential, it is necessary to identify the factors influencing uptake, especially among previous non-participants. This analysis of cross-sectional data involved 936 non-participants in screening colonoscopy aged 55 years or older in Germany. Differences between non-participants with and without future participation intentions were investigated in terms o

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Rahman, Dr Md Hasanur. "Colonoscopy Screening: An Optimal Early Diagnostic Choice for Colorectal Symptoms." Scholars Journal of Applied Medical Sciences 13, no. 04 (2025): 854–58. https://doi.org/10.36347/sjams.2025.v13i04.004.

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Background: Colorectal cancer (CRC) is an emerging public health challenge in Bangladesh, with increasing incidence due to lifestyle changes, dietary habits, and genetic predisposition. Early detection significantly improves prognosis, yet colonoscopy remains underutilized due to limited awareness and accessibility. Implementing routine colonoscopic screening could enhance early diagnosis and reduce CRC-related mortality. Objective: This study aimed to evaluate the necessity and effectiveness of early colonoscopy screening as the preferred diagnostic method for colorectal symptoms in Banglades

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Ahmed, Farid E., Mostafa M. Gouda, and Nancy C. Ahmed. "Use of Microfluidic Assays to Develop Reliable and Economic Nucleic Acid Application Technologies, Employing MicroRNAs for the Diagnostic Screening of Colon Cancer in Human Stool in Low-Resource Settings." International Journal of Nutrition 5, no. 4 (2020): 1–29. http://dx.doi.org/10.14302/issn.2379-7835.ijn-19-3123.

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Isolation methods that employ readily-available inexpensive supplies on the open market, which are reliable, as well as economical, such as nucleic acid amplification techniques (NAAT) based on microfluidic technology in low-resource research settings (LRRS) that meets the ASSURED guidelines are essential to develop a noninvasive diagnostic colon cancer screen in stool using micro(mi)RNA molecules. A combination of a microfluidic-based MiRNA stool test with a reliable rolling circle amplification/detection method applied to the quantification of miRNA molecules, result in an affordable sensiti

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Ahmed, Farid E., Mostafa M. Gouda, and Nancy C. Ahmed. "Use of Microfluidic Assays to Develop Reliable and Economic Nucleic Acid Application Technologies, Employing MicroRNAs for the Diagnostic Screening of Colon Cancer in Human Stool in Low-Resource Settings." International Journal of Nutrition 6, no. 1 (2020): 44–72. http://dx.doi.org/10.14302/issn.2379-7835.ijn-20-3418.

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Isolation methods that employ readily-available inexpensive supplies on the open market, which are reliable, as well as economical, such as nucleic acid amplification techniques (NAAT) based on microfluidic technology in low-resource research settings (LRRS) that meets the ASSURED guidelines are essential to develop a noninvasive diagnostic colon cancer screen in stool using micro(mi)RNA molecules. A combination of a microfluidic-based MiRNA stool test with a reliable rolling circle amplification/detection method applied to the quantification of miRNA molecules, result in an affordable sensiti

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Minutolo, Giuseppa, Palmira Immordino, Alessia Dolce, et al. "Could a Behavioral Model Explain Adherence to Second-Level Colonoscopy for Colon Cancer Screening? Results of a Cross-Sectional Study of the Palermo Province Population." International Journal of Environmental Research and Public Health 19, no. 5 (2022): 2782. http://dx.doi.org/10.3390/ijerph19052782.

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According to Italian Essential Levels of Assistance (ELA), a colonoscopy is strongly recommended after a positive fecal occult blood test (FOBT) due to its effectiveness in early colorectal cancer detection. Despite the evidence, the Palermo province population (Italy), after a positive FOBT, have a lower colonoscopy adherence compared to Italian standards. This cross-sectional study analyzed patients’ perceptions of colonoscopy procedures to understand the reasons for non-adherence. Patients with a positive FOBT who did not undergo a colonoscopy within the national organized screening program

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