Journal articles: 'Database centres'

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McLachlan, R. S. "The Canadian Epilepsy Database and Registry." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 25, S4 (November 1998): S27—S31. http://dx.doi.org/10.1017/s0317167100034946.

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ABSTRACT:Epilepsy encompasses medical, psychological, social and demographic factors which are best studied in large populations. The Canadian Epilepsy Database and Registry (CEDAR) is a comprehensive English language, multicentre epilepsy database which has been developed to study the impact of these and other factors on epilepsy in Canada. In addition, it can be used locally in the clinic for office record keeping, automated printout of a referral letter or graphing seizures and other data over time. The data in CEDAR are similar to what is found in the patient's chart. There are 20 participating centres across Canada which have entered data on over 8000 adult and pediatric epilepsy patients. The information in CEDAR will be available for research purposes to centres entering data as well as to academic researchers, the pharmaceutical industry and government agencies.

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Epelbaum, Stéphane, Claire Paquet, Jacques Hugon, Julien Dumurgier, David Wallon, Didier Hannequin, Thérèse Jonveaux, et al. "How many patients are eligible for disease-modifying treatment in Alzheimer’s disease? A French national observational study over 5 years." BMJ Open 9, no. 6 (June 2019): e029663. http://dx.doi.org/10.1136/bmjopen-2019-029663.

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ObjectiveWe aimed to study the epidemiology of the prodromal and mild stages of Alzheimer’s disease (AD) patients who are eligible for clinical trials with disease-modifying therapies.SettingsWe analysed two large complementary databases to study the incidence and characteristics of this population on a nationwide scope in France from 2014 to 2018. The National Alzheimer Database contains data from 357 memory centres and 90 private neurologists. Data from 2014 to 2018 have been analysed.ParticipantsPatients, 50–85 years old, diagnosed with AD who had an Mini-Mental State Exam (MMSE) score of ≥20 were included. We excluded patients with mixed and non-AD neurocognitive disorders.Primary outcome measureDescriptive statistics of the population of interest was the primary measure.ResultsIn the National Alzheimer Database, 550 198 patients were assessed. Among them, 72 174 (13.1%) were diagnosed with AD and had an MMSE ≥20. Using corrections for specificity of clinical diagnosis of AD, we estimated that about 50 000 (9.1%) had a prodromal or mild AD. In the combined electronic clinical records database of 11 French expert memory centres, a diagnosis of prodromal or mild AD, certified by the use of cerebrospinal fluid AD biomarkers, could be established in 195 (1.3%) out of 14 596 patients.ConclusionsAD was not frequently diagnosed at a prodromal or mild dementia stage in France in 2014 to 2018. Diagnosis rarely relied on a pathophysiological marker even in expert memory centres. National databases will be valuable to monitor early stage AD diagnosis efficacy in memory centres when a disease-modifying treatment becomes available.

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Koval, J. J., L. M. Kwarciak, M. G. A. Grace, and B. J. Lockwood. "A Comprehensive Database Management System for a Variety of Clinical Trials." Methods of Information in Medicine 26, no. 01 (January 1987): 24–30. http://dx.doi.org/10.1055/s-0038-1635477.

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SummaryA multicentre database management system has been developed which permits individual centres to enter, update, and retrieve their data while allowing detailed analysis to take place on a multicentre basis. Individual centres can access only their own data; summaries, reports and graphics output can be used as a teaching device for seminars and rounds. In one instance, the system provides interactive services to 12 kidney transplant centres spanning a distance of 5000 kilometres; the database contains 20,000,000 items.The database management system is discussed and comparisons are made with other available systems.

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Zdziarska, Joanna, Krzysztof Chojnowski, Anna Klukowska, Magdalena Łętowska, Andrzej Mital, Jacek Musiał, Maria Podolak-Dawidziak, et al. "The HemoRec Database as an Example of a Rare Diseases Registry." European Oncology & Haematology 07, no. 02 (2011): 147. http://dx.doi.org/10.17925/eoh.2011.07.02.147.

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Rare diseases constitute a major burden on public health, mainly due to the high cost of therapy and logistical difficulties (for example, the need to organise a network of designated treatment centres). National and international registries of rare diseases facilitate data collection and analysis for demographic, economic and research purposes. They are also useful for treatment centres and other healthcare providers and pharmaceutical companies developing orphan drugs. We present the HemoRec database, implemented in 2006 in six European countries, as an example of an international registry of inherited bleeding disorders. HemoRec is used in 15 Polish treatment centres and stores data on 1,100 patients with inherited bleeding disorders (amounting to 24.9% of all patients registered in the Polish central registry held at the Institute of Haematology and Blood Transfusion in Warsaw). It can be developed in the future into a national platform of data collection and exchange in the network of Polish, and hopefully also European, haemophilia treatment centres.

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Kyberd, P. J., D. J. Beard, and J. D. Morrison. "The population of users of upper limb prostheses attending the Oxford Limb Fitting Service." Prosthetics and Orthotics International 21, no. 2 (August 1997): 85–91. http://dx.doi.org/10.3109/03093649709164535.

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There is no central database that records the changing provision of prostheses in the United Kingdom. Experience suggests there have been some shifts in the population, particularly in the past decade. Because the detailed records of these changes are contained in the patients' medical records it is difficult to assess the substance of these data except on an individual basis; the larger picture requires the sifting of a centre's or many centres' data. This paper describes the analysis of one such set of records at the Oxford Limb Fitting Centre. It relates the profile of the population that attends the centre to the general population, and compares the information with that obtainable from other sources. The possible causes for the findings are discussed.

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Truong, Dongngan, Leo Lopez, Peter C. Frommelt, Jessica Stelter, Brenda Ni, Meryl S. Cohen, Ashwin Prakash, et al. "Challenges and lessons learned from the Pediatric Heart Network Normal Echocardiogram Database study." Cardiology in the Young 30, no. 4 (March 17, 2020): 456–61. http://dx.doi.org/10.1017/s1047951120000438.

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AbstractBackground:The Pediatric Heart Network Normal Echocardiogram Database Study had unanticipated challenges. We sought to describe these challenges and lessons learned to improve the design of future studies.Methods:Challenges were divided into three categories: enrolment, echocardiographic imaging, and protocol violations. Memoranda, Core Lab reports, and adjudication logs were reviewed. A centre-level questionnaire provided information regarding local processes for data collection. Descriptive statistics were used, and chi-square tests determined differences in imaging quality.Results:For the 19 participating centres, challenges with enrolment included variations in Institutional Review Board definitions of “retrospective” eligibility, overestimation of non-White participants, centre categorisation of Hispanic participants that differed from National Institutes of Health definitions, and exclusion of potential participants due to missing demographic data. Institutional Review Board amendments resolved many of these challenges. There was an unanticipated burden imposed on centres due to high numbers of echocardiograms that were reviewed but failed to meet submission criteria. Additionally, image transfer software malfunctions delayed Core Lab image review and feedback. Between the early and late study periods, the proportion of unacceptable echocardiograms submitted to the Core Lab decreased (14 versus 7%, p < 0.01). Most protocol violations were from eligibility violations and inadvertent protected health information disclosure (overall 2.5%). Adjudication committee reviews led to protocol changes.Conclusions:Numerous challenges encountered during the Normal Echocardiogram Database Study prolonged study enrolment. The retrospective design and flaws in image transfer software were key impediments to study completion and should be considered when designing future studies collecting echocardiographic images as a primary outcome.

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Temple, Jeromey, Tanara Sousa, Ruth Williams, Jay Stiles, Libby Brooke, and Josh Knight. "Understanding survey data available for researchers working in ageing: the CEPAR Metadata Database on Ageing." Australian Population Studies 5, no. 1 (May 30, 2021): 65–76. http://dx.doi.org/10.37970/aps.v5i1.83.

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Background For researchers working in gerontology or the demography of ageing, knowledge of and access to population-based data, which includes mature age respondents, is critical. The collection of metadata (information describing data) supports researchers in their search for relevant data. Aims This proof-of-concept project seeks to develop a metadata database including metadata on Australian sample surveys relevant to ageing over the period 2010–2018. Data and methods We used a five-stage approach to create the Centre for Excellence in Population Ageing Research (CEPAR) metadata database on ageing: 1) identification of in-scope survey datasets; 2) indexing the in-scope surveys; 3) scraping metadata from publicly available sources; 4) appending metadata to a master database; and 5) creation of a webtool to enable users to search and export metadata and obtain contact details for the relevant data custodian. Results The CEPAR Metadata Database webtool is available from: https://mspgh.unimelb.edu.au/centres-institutes/centre-for-health-policy/research-group/metadata-database. Conclusions Metadata database collections can assist researchers to identify what data has been collected (for their specific research interest in ageing), how it was collected and how to gain access to the data.

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Randriamampianina, I., and A. Chamberlain. "The development of a specific database for rehabilitation centres in Madagascar." Annals of Physical and Rehabilitation Medicine 61 (July 2018): e532. http://dx.doi.org/10.1016/j.rehab.2018.05.1240.

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Pagès, Pierre-Benoit, Jonathan Cottenet, Anne-Sophie Mariet, Alain Bernard, and Catherine Quantin. "In-hospital mortality following lung cancer resection: nationwide administrative database." European Respiratory Journal 47, no. 6 (March 10, 2016): 1809–17. http://dx.doi.org/10.1183/13993003.00052-2016.

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Our aim was to determine the effect of a national strategy for quality improvement in cancer management (the “Plan Cancer”) according to time period and to assess the influence of type and volume of hospital activity on in-hospital mortality (IHM) within a large national cohort of patients operated on for lung cancer.From January 2005 to December 2013, 76 235 patients were included in the French Administrative Database. Patient characteristics, hospital volume of activity and hospital type were analysed over three periods: 2005–2007, 2008–2010 and 2011–2013.Global crude IHM was 3.9%: 4.3% during 2005–2007, 4% during 2008–2010 and 3.5% during 2011–2013 (p<0.01). 296, 259 and 209 centres performed pulmonary resections in 2005–2007, 2008–2010 and 2011–2013, respectively (p<0.01). The risk of death was higher in centres performing <13 resections per year than in centres performing >43 resections per year (adjusted (a)OR 1.48, 95% CI 1.197–1.834). The risk of death was lower in the period 2011–2013 than in the period 2008–2010 (aOR 0.841, 95% CI 0.764–0.926). Adjustment variables (age, sex, Charlson score and type of resection) were significantly linked to IHM, whereas the type of hospital was not.The French national strategy for quality improvement seems to have induced a significant decrease in IHM.

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Bristow, Gillian, Max Munday, and Peter Gripaios. "Call Centre Growth and Location: Corporate Strategy and the Spatial Division of Labour." Environment and Planning A: Economy and Space 32, no. 3 (March 2000): 519–38. http://dx.doi.org/10.1068/a3265.

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The authors contribute to the developing literature on call centres by providing detailed empirical evidence on the spatial unevenness in the distribution of call centre activity. They argue that the driving forces of call centre growth, whether as the rationalisation of back-office functions or as entirely new entities, have been corporate strategy and the pursuit of low-cost competitive advantage. Thus, although technological developments at the heart of call centre operations render them relatively ‘footloose’ in locational terms, the search for specific characteristics makes certain regions (and parts of regions) more attractive than others. By using a sample database of call centres, the authors describe the characteristics of call centres in the United Kingdom in terms of size, sector, and spatial distribution. They then attempt to explain the determinants of call centre location at the county level through a multiple regression analysis. The results indicate that there is a propensity to site call centres close to existing concentrations of allied activity, with preferences for densely populated areas mediated by needs to maintain employee access and avoid staff turnover problems. This has important implications for the spatial division of labour, with call centre growth likely to reinforce existing spatial unevenness in employment in key service activities. The authors conclude by considering the implications of these findings for contemporary urban and regional development, as well as providing a number of suggestions for future research.

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Jacobs, Jeffrey P., James A. Quintessenza, Redmond P. Burke, Mark S. Bleiweis, Barry J. Byrne, Eric L. Ceithaml, William M. DeCampli, et al. "Analysis of regional congenital cardiac surgical outcomes in Florida using The Society of Thoracic Surgeons Congenital Heart Surgery Database." Cardiology in the Young 19, no. 4 (August 2009): 360–69. http://dx.doi.org/10.1017/s1047951109990151.

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AbstractBackgroundFlorida is the fourth largest state in the United States of America. In 2004, 218,045 live babies were born in Florida, accounting for approximately 1744 new cases of congenital heart disease. We review the initial experience of The Society of Thoracic Surgeons Congenital Heart Surgery Database with a regional outcomes report, namely the Society of Thoracic Surgeons Florida Regional Report.MethodsEight centres in Florida provide services for congenital cardiac surgery. The Children’s Medical Services of Florida provide a framework for quality improvement collaboration between centres. All congenital cardiac surgical centres in Florida have voluntarily agreed to submit data to the Society of Thoracic Surgeons Database. The Society of Thoracic Surgeons and Duke Clinical Research Institute prepared a Florida Regional Report to allow detailed regional analysis of outcomes for congenital cardiac surgery.ResultsThe report of 2007 from the Society of Thoracic Surgeons Congenital Heart Surgery Database includes details of 61,014 operations performed during the 4 year data harvest window, which extended from 2003 through 2006. Of these operations, 6,385 (10.5%) were performed in Florida. Discharge mortality in the data from Florida overall, and from each Florida site, with 95% confidence intervals, is not different from cumulative data from the entire Society of Thoracic Surgeons Database, both for all patients and for patients stratified by complexity.ConclusionsA regional consortium of congenital heart surgery centres in Florida under the framework of the Children’s Medical Services has allowed for inter-institutional collaboration with the goal of quality improvement. This experience demonstrates, first, that the database maintained by the Society of Thoracic Surgeons can provide the framework for regional analysis of outcomes, and second, that voluntary regional collaborative efforts permit the pooling of data for such analysis.

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Kanaujia Sukula, Shiva. "Indigenous database development in Indian research and development library and information centres." Online Information Review 29, no. 2 (April 2005): 193–207. http://dx.doi.org/10.1108/14684520510598057.

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Alder, Roger W., Paul R. Allen, Kevin R. Anderson, Craig P. Butts, Ezat Khosravi, Antonio Martín, Colette M. Maunder, A. Guy Orpen, and Christopher B. St. Pourçain. "Conformational control by quaternary centres: theory, database evidence and application to polymers." Journal of the Chemical Society, Perkin Transactions 2, no. 10 (1998): 2083–108. http://dx.doi.org/10.1039/a802623h.

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Bello-Salau, Habeeb, Adeiza James Onumanyi, David Michael, Ridwanullahi Isa, Caroline O. Alenoghena, and Henry Ohize. "A new automated smart cart system for modern shopping centres." Bulletin of Electrical Engineering and Informatics 10, no. 4 (August 1, 2021): 2028–36. http://dx.doi.org/10.11591/eei.v10i4.2762.

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Modern shopping centres are undoubtedly a beehive of intense shopping activities. However, customers are often plagued by salient challenges, which may include fatigue derived from pushing trolleys around the mall and prolonged sorting of bills by the cashier. These shopping challenges could be daunting for the elderly, disabled, pregnant and nursing mothers. In this paper, we addressed these shopping challenges by developing an autonomous shopping cart with the following characteristics; (1) it follows the customer’s movement relieving the need to push a cart, (2) it bills automatically all stock placed in the cart, (3) it prompts the customer to make payment and updates each stock via a local database. Our design adopts a Raspberry Pi, a camera and a few direct current motors programmed to achieve autonomy. We used an open-source cross platform software called XAMPP to create the database and used RFID tags to bill the items placed in the cart automatically. The system updates payments and communicates these transactions to a local database via nRF24 wireless transceivers. The experimental tests conducted demonstrate that our system successfully followed customers accurately within the mall. We consider our design a major contribution to the vision of automated shopping systems for the near future.

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Lemaignen, Adrien, Leslie Grammatico-Guillon, Pascal Astagneau, Simon Marmor, Tristan Ferry, Anne Jolivet-Gougeon, Eric Senneville, and Louis Bernard. "Computerized registry as a potential tool for surveillance and management of complex bone and joint infections in France." Bone & Joint Research 9, no. 10 (October 1, 2020): 635–44. http://dx.doi.org/10.1302/2046-3758.910.bjr-2019-0362.r1.

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Aims The French registry for complex bone and joint infections (C-BJIs) was created in 2012 in order to facilitate a homogeneous management of patients presented for multidisciplinary advice in referral centres for C-BJI, to monitor their activity and to produce epidemiological data. We aimed here to present the genesis and characteristics of this national registry and provide the analysis of its data quality. Methods A centralized online secured database gathering the electronic case report forms (eCRFs) was filled for every patient presented in multidisciplinary meetings (MM) among the 24 French referral centres. Metrics of this registry were described between 2012 and 2016. Data quality was assessed by comparing essential items from the registry with a controlled dataset extracted from medical charts of a random sample of patients from each centre. Internal completeness and consistency were calculated. Results Between 2012 and 2016, 30,607 presentations in MM were recorded corresponding to 17,748 individual patients (mean age 62.1 years (SD 18.4); 10,961 (61.8%) males). BJI was considered as complex for 63% of cases (n = 19,355), and 13,376 (44%) had prosthetic joint infections (PJIs). The controlled dataset, available for 19 centres, included 283 patients. Global consistency and completeness were estimated at 88.2% and 88.9%, respectively, considering missing items in the eCRFs as negative results. Conclusion This national registry is one of the largest prospective databases on BJI and its acceptable data quality parameters allow further use for epidemiological purposes. Cite this article: Bone Joint Res 2020;9(10):635–644.

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Kazakov, A. S., M. A. Darmostukova, T. M. Bukatina, N. Yu Velts, and R. N. Alyautdin. "Comparative Analysis of International Databases of Adverse Drug Reactions." Safety and Risk of Pharmacotherapy 8, no. 3 (September 18, 2020): 134–40. http://dx.doi.org/10.30895/2312-7821-2020-8-3-134-140.

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In 1968 the World Health Organisation initiated the development of an international programme for collection of data from the maximum number of sources about potential adverse effects of medicines. In order to implement this programme, a number of databases were created, such as the global database VigiBase, the European database EudraVigilance, and the database of the Eurasian Economic Union (EAEU). The aim of the present study was to compare approaches of the international spontaneous reports databases to collection, processing, and analysis of information on adverse drug reactions. It was demonstrated that the international databases VigiBase, EudraVigilance, and the EAEU database of adverse drug reactions contain different numbers of spontaneous reports, but serve the same objectives, namely to collect, process, and analyse information submitted as spontaneous reports. Unlike VigiBase that contains reports on authorised medicines coming from the national pharmacovigilance centres only, EudraVigilance also receives data from marketing authorisation holders and has reports on adverse drug reactions observed during clinical trials. The exchange of information between countries ensures rapid identification of safety signals concerning potential risks of medicines, and increases the likelihood of detecting rare and late-onset adverse reactions that may go unnoticed when analysing national data in a particular country. Spontaneous reports databases are an essential tool of the international drug safety monitoring community. Effective measures in this area will ultimately help to improve patients’ health and quality of life.

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Kholshchevnikov, V. V., A. A. Semin, and I. A. Taktaev. "Evacuation beginning time in healthcare centres." Vestnik Tomskogo gosudarstvennogo arkhitekturno-stroitel'nogo universiteta. JOURNAL of Construction and Architecture 23, no. 1 (February 26, 2021): 105–15. http://dx.doi.org/10.31675/1607-1859-2021-23-1-105-115.

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The population of healthcare centres includes patients with disabilities. Until recently, the parameters of their movement during evacuation remain unknown. A training evacuation (not announced for patients) is performed to determine these parameters. It is found that the parameters of the people movement, which determine the estimated evacuation time, are significantly lower than those of healthy people, or they are unable to move independently (in a hospital). The time of the beginning of the evacuation has not been studied in the literature. This paper presents for the first time the results of field observations concerning the evacuation time for patients with disabilities. These data form the initial statistical database. The training evacuation is performed in the outpatient building of Vladimirskii Moscow Regional Research Clinical Institute.

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Voženílek, Vít, Jan Michalík, Alžběta Brychtová, and Alena Vondráková. "SPATIAL DISTRIBUTION OF SPECIAL EDUCATION FOR VISION IMPAIRED PEOPLE." SOCIETY, INTEGRATION, EDUCATION. Proceedings of the International Scientific Conference 3 (July 24, 2015): 181. http://dx.doi.org/10.17770/sie2014vol3.731.

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The article treats spatial analysis distribution of activities within special education of vision impaired children, pupils and students in the Czech Republic. It response to the research questions: What are territorial differences in content and volume of special education of vision impaired people? Are there any regional disparities? The authors applied several scientific methods – a standardized form for recording of particular contact the teacher with vision impaired person in Special Education Centre, database design, spatial analysis and map compiling. The study confirms a significant increase of disability in higher age and dominant role of the family in the care for a person with vision impaired people. The research confirmed the dominant role of regions as special needs centres authorities. Based on a unique survey the study quantified special needs centres activity.

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Tarantino, Matteo, and Basile Zimmermann. "Database Green: Software, Environmentalism and Data Flows in China." China Quarterly 229 (January 31, 2017): 205–17. http://dx.doi.org/10.1017/s0305741016001600.

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AbstractSignificant efforts towards environmental transparency have been made by the Chinese government since 2008. This paper focuses on the technical decisions shaping a database of official pollution information built and operated by a Chinese NGO known as the Institute of Public and Environmental Affairs (IPE). Issues of standardization, power distribution and institutional fragmentation are discussed. The paper illustrates a case of NGOs integrating enforcement capabilities as data centres amidst the growing reliance on processes of informational governance of environmental issues.

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Kansy, Andrzej, Tjark Ebels, Christian Schreiber, Jeffrey P. Jacobs, Zdzislaw Tobota, and Bohdan Maruszewski. "Higher programmatic volume in paediatric heart surgery is associated with better early outcomes." Cardiology in the Young 25, no. 8 (December 2015): 1572–78. http://dx.doi.org/10.1017/s1047951115002073.

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AbstractObjectivePrevious analyses have suggested an association between centre volume and in-hospital mortality, post-operative complications, and mortality in those patients who suffer from a complication. We sought to determine the nature of this association using a multicentre cohort.MethodsAll the patients, aged 18 years or younger, undergoing heart surgery at centres participating in the European Congenital Heart Surgeons Database (2003–2013) were included. Programmes were grouped as follows: small <150; medium 150–250; large 251–349; very large >350. Multivariable logistic regression was used to identify the differences between groups with the adjusted in-hospital mortality, onset of any and/or major complication, and in-hospital mortality in those patients with any and/or major complication. The outcomes were adjusted for patient specific risk factors and surgical risk factors.ResultsThe data set consisted of 119,345 procedures performed in 99 centres. Overall, in-hospital mortality was 4.63%; complications occurred in 23.4% of the patients. In-hospital mortality in patients with complications was 13.82%. Multivariable logistic regression showed that the risk of in-hospital death was higher in low- and medium-volume centres (p<0.001). The rate of the occurrence of any post-operative complication in small, medium, and large programmes was lower compared with very large centres (p<0.001). Low- and medium-volume centres were associated with significantly higher mortality in patients with any complication (p<0.001).ConclusionsOur analysis showed that the risk of in-hospital mortality was lower in higher-volume centres. Although the risk of complications is higher in high-volume centres, the mortality associated with complications that occurred in these centres was lower.

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Eckhauser, Aaron, Sara K. Pasquali, Chitra Ravishankar, Linda M. Lambert, Jane W. Newburger, Andrew M. Atz, Nancy Ghanayem, et al. "Variation in care for infants undergoing the Stage II palliation for hypoplastic left heart syndrome." Cardiology in the Young 28, no. 10 (July 24, 2018): 1109–15. http://dx.doi.org/10.1017/s1047951118000999.

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AbstractBackgroundThe Single Ventricle Reconstruction trial randomised neonates with hypoplastic left heart syndrome to a systemic-to-pulmonary-artery shunt strategy. Patients received care according to usual institutional practice. We analysed practice variation at the Stage II surgery to attempt to identify areas for decreased variation and process control improvement.MethodsProspectively collected data were available in the Single Ventricle Reconstruction public-use database. Practice variation across 14 centres was described for 397 patients who underwent Stage II surgery. Data are centre-level specific and reported as interquartile ranges across all centres, unless otherwise specified.ResultsPreoperative Stage II median age and weight across centres were 5.4 months (interquartile range 4.9–5.7) and 5.7 kg (5.5–6.1), with 70% performed electively. Most patients had pre-Stage-II cardiac catheterisation (98.5–100%). Digoxin was used by 11/14 centres in 25% of patients (23–31%), and 81% had some oral feeds (68–84%). The majority of the centres (86%) performed a bidirectional Glenn versus hemi-Fontan. Median cardiopulmonary bypass time was 96 minutes (75–113). In aggregate, 26% of patients had deep hypothermic circulatory arrest >10 minutes. In 13/14 centres using deep hypothermic circulatory arrest, 12.5% of patients exceeded 10 minutes (8–32%). Seven centres extubated 5% of patients (2–40) in the operating room. Postoperatively, ICU length of stay was 4.8 days (4.0–5.3) and total length of stay was 7.5 days (6–10).ConclusionsIn the Single Ventricle Reconstruction Trial, practice varied widely among centres for nearly all perioperative factors surrounding Stage II. Further analysis may facilitate establishing best practices by identifying the impact of practice variation.

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Cheema, P. K., S. Raphael, R. El-Maraghi, J. Li, R. McClure, L. Zibdawi, A. Chan, J. C. Victor, A. Dolley, and A. Dziarmaga. "Rate of EGFR mutation testing for patients with non-squamous non-small cell lung cancer with implementation of reflex testing by pathologists." Current Oncology 24, no. 1 (February 28, 2017): 16. http://dx.doi.org/10.3747/co.24.3266.

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Background Testing for mutation of the EGFR (epidermal growth factor receptor) gene is a standard of care for patients with advanced nonsquamous non-small-cell lung cancer (nsclc). To improve timely access to EGFR results, a few centres implemented reflex testing, defined as a request for EGFR testing by the pathologist at the time of a nonsquamous nsclc diagnosis. We evaluated the impact of reflex testing on EGFR testing rates.Methods A retrospective observational review of the Web-based AstraZeneca Canada EGFR Database from 1 April 2010 to 31 March 2014 found centres within Ontario that had requested EGFR testing through the database and that had implemented reflex testing (with at least 2 years’ worth of data, including the pre- and post-implementation period).Results The 7 included centres had requested EGFR tests for 2214 patients. The proportion of pathologists requesting EGFR tests increased after implementation of reflex testing (53% vs. 4%); conversely, the proportion of medical oncologists requesting tests decreased (46% vs. 95%, p < 0.001). After implementation of reflex testing, the mean number of patients having EGFR testing per centre per month increased significantly [12.6 vs. 4.9 (range: 4.5–14.9), p < 0.001]. Before reflex testing, EGFR testing rates showed a significant monthly increase over time (1.37 more tests per month; 95% confidence interval: 1.19 to 1.55 tests; p < 0.001). That trend could not account for the observed increase with reflex testing, because an immediate increase in EGFR test requests was observed with the introduction of reflex testing (p = 0.003), and the overall trend was sustained throughout the post–reflex testing period (p < 0.001).Conclusions Reflex EGFR testing for patients with nonsquamous nsclc was successfully implemented at multiple centres and was associated with an increase in EGFR testing.

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Starre, Jan H. E. van der. "Automation at the RKD: a short overview." Art Libraries Journal 23, no. 2 (1998): 15–17. http://dx.doi.org/10.1017/s0307472200010919.

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The Netherlands Institute for Art History (RKD) is one of the largest art documentation centres in the world. It maintains collections of millions of reproductions and press clippings, as well as housing a sizeable library of approximately 400,000 books. In the past decade the RKD has begun setting up various automated systems for the management of these collections. The major systems in operation are the automated library with some 30,000 records online and accessible for visitors, a database with bio- and bibliographical information on artists, and the recently initiated image database. Plans for the future include in-house and web access to all databases, continued improvement and expansion of the systems, retrospective conversion of parts of the collections and publication of CD-ROMs.

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Read, Tim R. H., Marcus Y. Chen, Catriona S. Bradshaw, Sriyakantha Beneragama, and Christopher K. Fairley. "Do all women attending urban sexual health services need testing for gonorrhoea?" Sexual Health 2, no. 4 (2005): 259. http://dx.doi.org/10.1071/sh05029.

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Asymptomatic women are often screened for gonorrhoea at Australian sexual health centres. The medical records of all women diagnosed with gonorrhoea at the Melbourne Sexual Health Centre (MSHC) between January 2002 and December 2003 were audited and the database was examined for risk factors in all women tested in 2003. Fifteen cases of gonorrhoea were identified among women at MSHC, all had symptoms or an identifiable risk factor. Asymptomatic women without risk factors may not require screening for Neisseria gonorrhoeae in low prevalence populations.

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Maguire, Sarah, Lois J. Surgenor, Suzanne Abraham, and Peter Beumont. "An International Collaborative Database: Its Use in Predicting Length of Stay for Inpatient Treatment of Anorexia Nervosa." Australian & New Zealand Journal of Psychiatry 37, no. 6 (December 2003): 741–47. http://dx.doi.org/10.1080/j.1440-1614.2003.01257.x.

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Objective: We describe the establishment of an Australasian multisite research database for inpatient treatment of anorexia nervosa (AN). Using this database, the second aim of this study is to investigate the extent to which length of stay (LOS) in participating facilities could be predicted at admission from patient, clinical, and site variables. Method: Standardized demographic and clinical data were collated for 213 admission episodes involving 154 participants over a 20 month period from five Australian and one New Zealand specialist treatment centres. Results: While nine variables significantly predicted LOS on univariate analysis, linear regression determined that only body mass index, and having had 2–3 previous admissions made significant independent contributions to LOS. Discussion: Multisite databases offer a viable means by which to conduct clinical research, particularly in regard to low prevalence disorders such as AN. Their additional advantage is that of involving front-line practitioners recruiting participants more likely to be representative of cases seen across treatment centres. At just under a fifth of the total variance predicted by the best-fit model, LOS in hospital remains an aspect of AN treatment difficult to predict, and future studies need to explore variables other than the obvious demographic or clinical issues at admission. The clinical and planning implications are discussed

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Eyland, Simon, Simon Corben, and Jenny Barton. "Suicide Prevention in New South Wales Correctional Centres." Crisis 18, no. 4 (July 1997): 163–69. http://dx.doi.org/10.1027/0227-5910.18.4.163.

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The New South Wales Department of Corrective Services has introduced a number of suicide prevention measures in order to deal with the problem of inmate suicides. This article describes the measures. The article also shows that the characteristics of the incarcerated population differ greatly from those in the community. Findings from the self-harm database 1991-1995 show that, nevertheless, there are some unique characteristics of the group of self-harmers and fatal self-harmers. These findings are discussed in relation to the preventive measures that are introduced in the NSW correctional centers.

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Fukuda, Takanari, Shin Okumura, and Naohiko Otuka. "Completeness of experimental fission product yields in EXFOR database." EPJ Web of Conferences 239 (2020): 05013. http://dx.doi.org/10.1051/epjconf/202023905013.

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The Nuclear Reaction Data Centres (NRDC) collaborate on worldwide compilation and dissemination of experimental nuclear reaction data by developing and maintaining the EXFOR database. With the growing interests in the fission product yields of various projectiles and a wide range of energies, several evaluation activities are ongoing. In line with these activities, the IAEA conducted completeness check of fission product yield data in EXFOR against two experimental datasets developed by the ENDF and UKFY library evaluators. The present status and statistics of these datasets as well as the result of the EXFOR completeness review are presented.

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Ting Trouilloud, Kae, Nathalie Sanlaville, Sandrine Yvars, and Anne Savey. "Relevance of a French National Database Dedicated to Infection Prevention and Control (NosoBase®): A Three-Step Quality Evaluation of a Specialized Bibliographic Database." Evidence Based Library and Information Practice 14, no. 1 (March 14, 2019): 33–44. http://dx.doi.org/10.18438/eblip29448.

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Abstract Objective – NosoBase® is a collection of documentation centres with a national bibliographic database dedicated to infection prevention and control (IPC), with over 20 years of experience in France. As a quality assurance activity, this study was conducted in 2017 with a three-step approach to evaluate the bibliographic database regarding (1) the availability and coverage of citations; (2) the scope and relevance of content; and (3) the quality of the documentation centre services. Methods – The three-step quality approach involved (1) evaluating the availability and coverage of citations in NosoBase® by searching for the bibliographic citations of three systematic reviews on hand hygiene practices, published recently in three different peer-reviewed international journals; (2) evaluating the scope and relevance of content in NosoBase® by searching for all documents from 2015 indexed in NosoBase® under hand hygiene related keywords, and analyzing according to publication language, document type (e.g., legislation, research, or guidelines), and target audience; and 3) evaluating the strengths, weaknesses, and opportunities of the documentation centre services, with interviews involving the librarians. Results – NosoBase® contained 70.8%-80.9% of references directly concerning hand hygiene cited by the three systematic reviews. Of the 200 articles indexed in NosoBase® under hand hygiene related keywords in 2015, 22.5% were French language based, with a significant representation of French non-indexed literature. The analysis of the documentation centre services highlighted future opportunities for growth, building on the strengths of experience and collaborations, to improve marketing and usability, targeting francophone IPC professionals. Conclusion – Specialized bibliographic databases may be useful and time efficient for the retrieval of relevant specialized content. NosoBase® has significant relevance to French and francophone healthcare professionals in its representation of French documentation and healthcare literature not otherwise indexed internationally. NosoBase® needs to highlight its resources and adapt its services to allow easier access to its content.

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Bromley, Pamela. "Locating Canadian Writing Centres: An Empirical Investigation." Canadian Journal for Studies in Discourse and Writing/Rédactologie 27 (May 16, 2017): 24–41. http://dx.doi.org/10.31468/cjsdwr.578.

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As writing centres in Canada face challenges to their existence, funding, and stature, it may be helpful to situate the Canadian experience empirically. This project investigates the number of, geographical, institutional, and physical locations of, and longevity of Canadian writing centres using information from an original database and survey examining writing centres located outside the United States. In the study, findings from Canada are compared to those from the United States, where the only other comprehensive investigations of writing centres have taken place. Results demonstrate that 123 writing centres in Canada are located in all 10 Canadian provinces as well as the Yukon territory, almost half of centres operate under the academic affairs umbrella of their university and are physically located in the library, and that while writing centres in Canada are newer, on average, than their U.S. peers, they may be located in proportionally more universities. Unfortunately, the changes Canadian writing centres are experiencing are not new, as writing centres have previously faced challenges to their existence and place in the university. However, information about the number, institutional and physical location, and longevity of Canadian writing centres may be useful to administrators as they advocate for and further develop their writing centres.

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Grothe, E., H. Meekes, and R. de Gelder. "Searching for stereoisomerism in crystallographic databases: algorithm, analysis and chiral curiosities." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 73, no. 3 (June 1, 2017): 453–65. http://dx.doi.org/10.1107/s2052520617001962.

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The automated identification of chiral centres in molecular residues is a non-trivial task. Current tools that allow the user to analyze crystallographic data entries do not identify chiral centres in some of the more complex ring structures, or lack the possibility to determine and compare the chirality of multiple structures. This article presents an approach to identify asymmetric C atoms, which is based on the atomic walk count algorithm presented by Rücker & Rücker [(1993),J. Chem. Inf. Comput. Sci.33, 683–695]. The algorithm, which we implemented in a computer program namedChiChi, is able to compare isomeric residues based on the chiral centres that were identified. This allows for discrimination between enantiomers, diastereomers and constitutional isomers that are present in crystallographic databases.ChiChiwas used to process 254 354 organic entries from the Cambridge Structural Database (CSD). A thorough analysis of stereoisomerism in the CSD is presented accompanied by a collection of chiral curiosities that illustrate the strength and versatility of this approach.

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Zink, A. "The national database of the German Collaborative Arthritis Centres: I. Structure, aims, and patients." Annals of the Rheumatic Diseases 60, no. 3 (March 1, 2001): 199–206. http://dx.doi.org/10.1136/ard.60.3.199.

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Farrell, Helena K. "Review ofResource Centres on Urban Agriculture & Food Security (RUAF) Online Library & Database." Journal of Agricultural & Food Information 13, no. 2 (April 2012): 198–200. http://dx.doi.org/10.1080/10496505.2012.667359.

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Pruess, Manuela, Paul Kersey, and Rolf Apweiler. "Integrating Genomic and Proteomic Data: The Integr8 Project." Journal of Integrative Bioinformatics 1, no. 1 (December 1, 2004): 108–15. http://dx.doi.org/10.1515/jib-2004-9.

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Summary Integr8 (http://www.ebi.ac.uk/integr8/) has been developed to provide an integration layer for the exploitation of genomic and proteomic data. High-quality databases from major bioinformatics centres in Europe are included, and some core data and the relationships of biological entities to each other and to entries in other databases are stored. Thus, a framework exists that allows for new kinds of data to be integrated, and an entity-centric view of complete genomes and proteomes is offered. Integr8 is an automatically populated database, providing different entry points to the data, depending on the user’s entity of interest. The Proteome Analysis database for statistical analysis and the Genome Reviews for annotated genome information are the main developments within the Integr8 project. With the BioMart application, an interactive querying tool for performing customisable proteome analysis and data mining is offered. Future developments will especially focus on the Genome Reviews, including mapping not yet annotated protein sequences onto their corresponding genomes, generating new predictions for non-coding RNA genes, and generally extending the scope to lower metazoan organisms.

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Chung, Henry V., Mark Riley, Jin K. Ho, Benjamin Leung, Gareth P. Jevon, Laura T. Arbour, Colin Barker, Richard Schreiber, and Eric M. Yoshida. "Retrospective Review of Pediatric and Adult Autoimmune Hepatitis in Two Quaternary Care Centres in British Columbia: Increased Prevalence Seen in British Columbia’S First Nations Community." Canadian Journal of Gastroenterology 21, no. 9 (2007): 565–68. http://dx.doi.org/10.1155/2007/757906.

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BACKGROUND: It has been previously reported that British Columbia’s (BC’s) First Nations (Aboriginal) community has an increased risk of autoimmune diseases, including rheumatological conditions (rheumatoid arthritis, systemic lupus) and primary biliary cirrhosis. The researchers hypothesized that this community may also be at increased risk for autoimmune hepatitis (AIH).METHODS: Independent, retrospective reviews of the databases of two separate tertiary/quaternary British Columbia university-affiliated health care institutions, the Adult Liver Transplant Program of the BC Transplant Society and the Division of Pediatric Gastroenterology, BC Children’s Hospital (Vancouver, BC), were performed. All patients referred with a diagnosis of probable or definite AIH who identified themselves as being of First Nations descent from 1988 to 2004 were reviewed. The liver transplant database records all adult patients in the province referred for transplant assessment. The pediatric database records all children referred to the BC Children’s Hospital.RESULTS: A total of 68 adult patients with a definite or probable diagnosis of AIH were referred to the liver transplant program. Twelve patients (17.6%) were Aboriginal, 11 of which were female. Similarly, a total of 30 children with probable or definite AIH were identified from the pediatric database. Six of these cases (20%) were identified in Aboriginal children.CONCLUSIONS: The findings suggest an increased prevalence of AIH among BC’s First Nations community. A disproportionate First Nations representation was found on independent review of two databases. Future studies are needed to determine the true prevalence of AIH in this community, and to uncover the genetic predisposition and the environmental triggers explaining this phenomenon.

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Franconetti, Antonio, and Antonio Frontera. "“Like–like” tetrel bonding interactions between Sn centres: a combinedab initioand CSD study." Dalton Transactions 48, no. 30 (2019): 11208–16. http://dx.doi.org/10.1039/c9dt01953g.

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In this manuscript, we combine a search in the Cambridge Structural Database (CSD) andab initiocalculations (RI-MP2/def2-TZVP level of theory) to analyse the ability of Sn to establish ‘like–like’ tetrel bonding interactions.

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Wappenschmidt, Barbara, Jan Hauke, Ulrike Faust, Dieter Niederacher, Lisa Wiesmüller, Gunnar Schmidt, Evi Groß, et al. "Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer." Geburtshilfe und Frauenheilkunde 80, no. 04 (April 2020): 410–29. http://dx.doi.org/10.1055/a-1110-0909.

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AbstractMore than ten years ago, the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) set up a panel of experts (VUS Task Force) which was tasked with reviewing the classifications of genetic variants reported by individual centres of the GC-HBOC to the central database in Leipzig and reclassifying them, where necessary, based on the most recent data. When it evaluates variants, the VUS Task Force must arrive at a consensus. The resulting classifications are recorded in a central database where they serve as a basis for ensuring the consistent evaluation of previously known and newly identified variants in the different centres of the GC-HBOC. The standardised VUS evaluation by the VUS Task Force is a key element of the recall system which has also been set up by the GC-HBOC. The system will be used to pass on information to families monitored and managed by GC-HBOC centres in the event that previously classified variants are reclassified based on new information. The evaluation algorithm of the VUS Task Force was compiled using internationally established assessment methods (IARC, ACMG, ENIGMA) and is presented here together with the underlying evaluation criteria used to arrive at the classification decision using a flow chart. In addition, the characteristics and special features of specific individual risk genes associated with breast and/or ovarian cancer are discussed in separate subsections. The URLs of relevant databases have also been included together with extensive literature references to provide additional information and cover the scope and dynamism of the current state of knowledge on the evaluation of genetic variants. In future, if criteria are updated based on new information, the update will be published on the website of the GC-HBOC (https://www.konsortium-familiaerer-brustkrebs.de/).

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Lachininsky, Stanislav, and Ivan Sorokin. "Spatial structure and development of settlements in the Saint Petersburg agglomeration." Baltic Region 13, no. 1 (2021): 48–69. http://dx.doi.org/10.5922/2079-8555-2021-1-3.

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This article explores the spatial structure and development of settlements comprising the Saint Petersburg agglomeration. Previous studies and database sources, which were never used before (the Federal Tax Service [FTS] database and SPARK-Interfax), are analysed to reveal factors in the economic development of metropolitan areas as well as to understand how settlements develop in Russia’s second-largest city agglomeration. The borders and composition of the Saint Petersburg agglomeration are brought up to date. Examining the population size of the settlements helps locate the ‘growth belt’ of the agglomeration. Lists of major enterprises of the city and the region make it possible to identify patterns in the economic development of the study area. The SPARK-Interfax database aids in clarifying relationships between spatial elements of the agglomeration (its core and satellites) in the distribution of revenues of economic agents. Data on the location of the largest retail stores — shopping malls and hypermarkets — are used to identify the main centres of commerce in the Saint Petersburg agglomeration. A map chart has been drawn using 2GIS and Yandex Maps geoinformation services. An important step in agglomeration analysis is the identification of residential development hotspots. FTS data on property tax base are the main source of relevant information. FTS reports contain data on the number of residential buildings and units covered by the database. Further, FTS statistics is employed to trace income and job distribution across the study area. The current functions of settlement in the Saint Petersburg agglomeration have been determined. According to the findings, the spatial structure of the agglomeration has three groups of ‘backbone centres’. The agglomeration includes a core, a population growth area (‘growth belt’), commuting sources and recipients, and ‘backbone centres’.

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Elekonawo, Fortuné M. K., Manon M. D. van der Meeren, Geert A. Simkens, Johannes H. W. de Wilt, Ignace H. de Hingh, and Andreas J. A. Bremers. "Comparison of 2 Perioperative Management Protocols and Their Influence on Postoperative Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Standard Parenteral Nutrition, Selective Bowel Decontamination and Suprapubic Catheters?" Digestive Surgery 36, no. 5 (July 6, 2018): 394–401. http://dx.doi.org/10.1159/000490068.

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Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is associated with considerable postoperative morbidity, including ileus and infectious complications. Perioperative care is believed to be an important factor for the development and treatment of postoperative morbidity. Patients and Methods: Data on case-matched patients from a retrospective database of 2 Dutch HIPEC centres was compared. Patient selection and procedures were identical in both hospitals although perioperative management items differ slightly. In centre B, immediate total parenteral nutrition (TPN), suprapubic urine bladder catheter placement (SPCs) and selective decontamination of the digestive-tract are standard care for CRS-HIPEC patients, while in centre A, they are not. Results: From a total of 223 patients, 68 consecutive patients from centre B were compared to 68 matched patients from centre A. TPN was administered to 54.4% of patients in centre A because of prolonged ileus, whereas it was standard of care in centre B. In all, 105 (77.2%) patients experienced postoperative complications including 17.6% who had a grades III–IV complication. The incidence of grade III-V complications was 18 (26.4%) in centre A and 8 (11.8%) in centre B (p = 0.03). Median hospital stay was 12 days (7–84) in A and 11(6–80) in centre B (p = 0.546). Conclusions: Gastrointestinal recovery after CRS-HIPEC seems to take longer as compared to other surgical procedures. Between the 2 centres, a significant difference in severe complications was found, while standard TPN, selective bowel decontamination and SPCs were the only identified differences in perioperative care.

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Pacurariu, Alexandra, Kelly Plueschke, Patricia McGettigan, Daniel R. Morales, Jim Slattery, Dagmar Vogl, Thomas Goedecke, Xavier Kurz, and Alison Cave. "Electronic healthcare databases in Europe: descriptive analysis of characteristics and potential for use in medicines regulation." BMJ Open 8, no. 9 (September 2018): e023090. http://dx.doi.org/10.1136/bmjopen-2018-023090.

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ObjectiveElectronic healthcare databases (EHDs) are useful tools for drug development and safety evaluation but their heterogeneity of structure, validity and access across Europe complicates the conduct of multidatabase studies. In this paper, we provide insight into available EHDs to support regulatory decisions on medicines.MethodsEHDs were identified from publicly available information from the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance resources database, textbooks and web-based searches. Databases were selected using criteria related to accessibility, longitudinal dimension, recording of exposure and outcomes, and generalisability. Extracted information was verified with the database owners.ResultsA total of 34 EHDs were selected after applying key criteria relevant for regulatory purposes. The most represented regions were Northern, Central and Western Europe. The most frequent types of data source were electronic medical records (44.1%) and record linkage systems (29.4%). The median number of patients registered in the 34 data sources was 5 million (range 0.07–15 million) while the median time covered by a database was 18.5 years. Paediatric patients were included in 32 databases (94%). Completeness of information on drug exposure was variable. Published validation studies were found for only 17 databases (50%). Some level of access exists for 25 databases (73.5%), and 23 databases (67.6%) can be linked through a personal identification number to other databases with parent–child linkage possible in 7 (21%) databases. Eight databases (23.5%) were already transformed or were in the process of being transformed into a common data model that could facilitate multidatabase studies.ConclusionA Few European databases meet minimal regulatory requirements and are readily available to be used in a regulatory context. Accessibility and validity information of the included information needs to be improved. This study confirmed the fragmentation, heterogeneity and lack of transparency existing in many European EHDs.

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Schöfl, Christof, Martin Grussendorf, Jürgen Honegger, Anke Tönjes, Daniel Thyroke-Gronostay, Bernhard Mayr, Jochen Schopohl, and _. _. "Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey." European Journal of Endocrinology 172, no. 4 (April 2015): 351–56. http://dx.doi.org/10.1530/eje-14-0844.

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ContextDisease control is a prime target in acromegaly treatment. This should be achievable in the vast majority of patients by available treatment options. For unknown reasons, however, a significant number of patients do not achieve disease control.ObjectiveTo investigate reasons for failure to achieve disease control in long-standing acromegaly.Design and methodsSurvey based on the German Acromegaly Registry database (1755 patients in 57 centres). Questionnaires were sent to 47 centres treating 178 patients with elevated disease markers (IGF1 and GH) at the last documented database visit out of 1528 patients with a diagnosis dated back ≥2 years. Thirty-three centres returned anonymised information for 120 patients (recall rate 67.4%).ResultsMedian age of the 120 patients (58 females) was 57 years (range 17–84). Ninety-four patients had at least one operation, 29 had received radiotherapy and 71 had been previously treated medically. Comorbidities were reported in 67 patients. In 61 patients, disease activity had been controlled since the last documented database visit, while 59 patients still had biochemically active disease. Reasons were patients' denial to escalate therapy (23.3%), non-compliance (20.6%), fluctuating insulin-like growth factor 1 (IGF-1) and growth hormone (GH) levels with normal values at previous visits (23.3%) and modifications in pharmacotherapy (15.1%). Therapy resistance (9.6%), drug side effects (4.1%) and economic considerations (4.1%) were rare reasons.ConclusionsMain reasons for long-standing active acromegaly were patients' lack of motivation to agree to therapeutic recommendations and non-compliance with medical therapy. Development of patient education programmes could improve long-term control and thus prognosis of acromegalic patients.

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Min, Jinsoo, Hyung Woo Kim, Helen R. Stagg, Marc Lipman, Molebogeng X. Rangaka, Jun-Pyo Myong, Hyeon Woo Yim, et al. "Latent tuberculosis infection screening and treatment in congregate settings (TB FREE COREA): protocol for a prospective observational study in Korea." BMJ Open 10, no. 2 (February 2020): e034098. http://dx.doi.org/10.1136/bmjopen-2019-034098.

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IntroductionSouth Korea regards tuberculosis (TB) incidence in congregate settings as a serious problem. To this end, systematic latent TB infection (LTBI) diagnosis and treatment were provided to approximately 1.2 million individuals in high-risk congregate settings.Methods and analysisWe designed a prospective cohort study of individuals tested for LTBI, based on the data collected on all persons screened for LTBI as part of the 2017 congregate settings programme in South Korea. Four types of databases are kept: LTBI screening database (personal information and LTBI test results), national health information (NHI) database (socio-demographic data and comorbidities), public healthcare information system (PHIS) database, and the Korean national TB surveillance system database (TB outcomes). Information regarding LTBI treatment at private hospitals and public health centres is collected from NHI and PHIS databases, respectively. The screening data are cleaned, duplicates are removed, and, where appropriate, re-coded to analyse specific exposures and outcomes. The primary objective is to compare the number of active TB cases prevented within 2 years between participants undergoing treatment and not undergoing treatment in the LTBI screening programme in congregate settings. Cascade of care for LTBI diagnosis and treatment will be evaluated among those with a positive LTBI test result. A Cox proportional hazards model will be applied to determine the risk factors for developing active TB.Ethics and disseminationThe protocol is approved by the institutional review boards of Incheon St. Mary’s Hospital, the Catholic University of Korea. Study results will be disseminated through peer-reviewed journals and conference presentations.Trial registration numberKCT0003905

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Clark, Barry, Bartosz Wachowiak, Ewan W. Crawford, Zenon Jakubowski, and Janusz Kabata. "LIS–lnterlink—connecting laboratory information systems to remote primary health–care centres via the Internet." Journal of Automatic Chemistry 20, no. 3 (1998): 77–81. http://dx.doi.org/10.1155/s1463924698000091.

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A pilot study was performed to evaluate the feasibility of using the Internet to securely deliver patient laboratory results, and the system has subsequently gone into routine use in Poland. The system went from design to pilot and then to live implementation within a four-month period, resulting in the LIS-Interlink software product. Test results are retrieved at regular intervals from the BioLinkTMLIS (Laboratory Information System), encrypted and transferred to a secure area on the Web server. The primary health-care centres dial into the Internet using a local-cell service provided by Polish Telecom (TP), obtain a TCP/IP address using the TP DHCP server, and perform HTTP ‘get’ and ‘post’ operations to obtain the files by secure handshaking. The data are then automatically inserted into a local SQL database (with optional printing of incoming reports)for cumulative reporting and searching functions. The local database is fully multi-user and can be accessed from different clinics within the centres by a variety of networking protocols.

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Rosenblatt, Eduardo, Joanna Izewska, Yavuz Anacak, Yaroslav Pynda, Pierre Scalliet, Mathieu Boniol, and Philippe Autier. "Radiotherapy capacity in European countries: an analysis of the Directory of Radiotherapy Centres (DIRAC) database." Lancet Oncology 14, no. 2 (February 2013): e79-e86. http://dx.doi.org/10.1016/s1470-2045(12)70556-9.

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Degtyarenko, K. "PROMISE: a database of information on prosthetic centres and metal ions in protein active sites." Nucleic Acids Research 26, no. 1 (January 1, 1998): 376–81. http://dx.doi.org/10.1093/nar/26.1.376.

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Gaies, Michael, Janet E. Donohue, Gina M. Willis, Andrea T. Kennedy, John Butcher, Mark A. Scheurer, Jeffrey A. Alten, et al. "Data integrity of the Pediatric Cardiac Critical Care Consortium (PC4) clinical registry." Cardiology in the Young 26, no. 6 (September 11, 2015): 1090–96. http://dx.doi.org/10.1017/s1047951115001833.

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AbstractBackgroundClinical databases in congenital and paediatric cardiac care provide a foundation for quality improvement, research, policy evaluations and public reporting. Structured audits verifying data integrity allow database users to be confident in these endeavours. We report on the initial audit of the Pediatric Cardiac Critical Care Consortium (PC4) clinical registry.Materials and methodsParticipants reviewed the entire registry to determine key fields for audit, and defined major and minor discrepancies for the audited variables. In-person audits at the eight initial participating centres were conducted during a 12-month period. The data coordinating centre randomly selected intensive care encounters for review at each site. The audit consisted of source data verification and blinded chart abstraction, comparing findings by the auditors with those entered in the database. We also assessed completeness and timeliness of case submission. Quantitative evaluation of completeness, accuracy, and timeliness of case submission is reported.ResultsWe audited 434 encounters and 29,476 data fields. The aggregate overall accuracy was 99.1%, and the major discrepancy rate was 0.62%. Across hospitals, the overall accuracy ranged from 96.3 to 99.5%, and the major discrepancy rate ranged from 0.3 to 0.9%; seven of the eight hospitals submitted >90% of cases within 1 month of hospital discharge. There was no evidence for selective case omission.ConclusionsBased on a rigorous audit process, data submitted to the PC4 clinical registry appear complete, accurate, and timely. The collaborative will maintain ongoing efforts to verify the integrity of the data to promote science that advances quality improvement efforts.

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Lacasse, Yves, Jean-Marc Daigle, Sylvie Martin, and François Maltais. "Validity of Chronic Obstructive Pulmonary Disease Diagnoses in a Large Administrative Database." Canadian Respiratory Journal 19, no. 2 (2012): e5-e9. http://dx.doi.org/10.1155/2012/260374.

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BACKGROUND: Administrative databases are often used for research purposes, with minimal attention devoted to the validity of the included diagnoses.AIMS: To determine whether the principal diagnoses of chronic obstructive pulmonary disease (COPD) made in hospitalized patients and recorded in a large administrative database are valid.METHODS: The medical charts of 1221 patients hospitalized in 40 acute care centres in Quebec and discharged between April 1, 2003 and March 31, 2004, with a principal discharge diagnosis of COPD (International Classification of Diseases, Ninth Revisioncodes 491, 492 or 496) were reviewed. The diagnosis of COPD was independently adjudicated by two pulmonologists using clinical history (including smoking status) and spirometry. The primary outcome measure was the positive predictive value (PPV) of the database for the diagnosis of COPD (ie, the proportion of patients with an accurate diagnosis of COPD corroborated by clinical history and spirometry).RESULTS: The diagnosis of COPD was validated in 616 patients (PPV 50.4% [95% CI 47.7% to 53.3%]), with 372 patients (30.5%) classified as ‘indeterminate’. Older age and female sex were associated with a lower probability of an accurate diagnosis of COPD. Hospitalization in a teaching institution was associated with a twofold increase in the probability of a correct diagnosis.CONCLUSIONS: The results support the routine ascertainment of the validity of diagnoses before using administrative databases in clinical and health services research.

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Ou, Ziqiang, and Jianjun Zhu. "AIS Database Powered by GIS Technology for Maritime Safety and Security." Journal of Navigation 61, no. 4 (October 2008): 655–65. http://dx.doi.org/10.1017/s0373463308004888.

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The Automatic Identification System (AIS) is an efficient tool to exchange positioning data among participating naval units and land control centres. It was developed primarily as an advanced tool for assistance to sailors during navigation and for the safety of the life at sea. Maritime security has become a major concern for all coastal nations, especially after September 11, 2001. The fundamental requirement is maritime domain awareness via identification, tracking and monitoring of vessels within their waters and this is exactly what an AIS could bring. This paper will be focused on how the AIS-derived information could be used for coastal security, maritime traffic management, vessel tracking and monitoring with the help of GIS technology. The AIS data used in this paper was collected by the Canadian national aerial surveillance program.

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Agbelade, Aladesanmi D., Jonathan C. Onyekwelu, and Matthew B. Oyun. "Tree Species Richness, Diversity, and Vegetation Index for Federal Capital Territory, Abuja, Nigeria." International Journal of Forestry Research 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/4549756.

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This study was conducted to investigate the tree species richness and diversity of urban and periurban areas of the Federal Capital Territory (FCT), Abuja, Nigeria, and produce Normalized Difference Vegetation Index (NDVI) for the territory. Data were collected from urban (Abuja city) and periurban (Lugbe) areas of the FCT using both semistructured questionnaire and inventory of tree species within green areas. In the study location, all trees with diameter at breast height (dbh) ≥ 10 cm were identified; their dbh was measured and frequency was taken. The NDVI was calculated in ArcGIS 10.3 environment using standard formula. A cumulative total of twenty-nine (29) families were encountered within the FCT, with 27 occurring in Abuja city (urban centre) and 12 in Lugbe (periurban centre) of the FCT. The results of Shannon-Wiener diversity index(H′)for the two centres are 3.56 and 2.24 while Shannon’s maximum diversity index(Hmax)is 6.54 (Abuja city) and 5.36 (Lugbe) for the urban (Abuja city) and periurban (Lugbe) areas of the Federal Capital Territory (FCT). The result of tree species evenness (Shannon’s equitability (EH) index) in urban and periurban centres was 0.54 and 0.42, respectively. The study provided baseline information on urban and periurban forests in the FCT of Nigeria, which can be used for the development of tree species database of the territory.

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Smith, David Anthony, Tingyan Wang, Oliver Freeman, Charles Crichton, Hizni Salih, Philippa Clare Matthews, Jim Davies, et al. "National Institute for Health Research Health Informatics Collaborative: development of a pipeline to collate electronic clinical data for viral hepatitis research." BMJ Health & Care Informatics 27, no. 3 (November 2020): e100145. http://dx.doi.org/10.1136/bmjhci-2020-100145.

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ObjectiveThe National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) is a programme of infrastructure development across NIHR Biomedical Research Centres. The aim of the NIHR HIC is to improve the quality and availability of routinely collected data for collaborative, cross-centre research. This is demonstrated through research collaborations in selected therapeutic areas, one of which is viral hepatitis.DesignThe collaboration in viral hepatitis identified a rich set of datapoints, including information on clinical assessment, antiviral treatment, laboratory test results and health outcomes. Clinical data from different centres were standardised and combined to produce a research-ready dataset; this was used to generate insights regarding disease prevalence and treatment response.ResultsA comprehensive database has been developed for potential viral hepatitis research interests, with a corresponding data dictionary for researchers across the centres. An initial cohort of 960 patients with chronic hepatitis B infections and 1404 patients with chronic hepatitis C infections has been collected.ConclusionFor the first time, large prospective cohorts are being formed within National Health Service (NHS) secondary care services that will allow research questions to be rapidly addressed using real-world data. Interactions with industry partners will help to shape future research and will inform patient-stratified clinical practice. An emphasis on NHS-wide systems interoperability, and the increased utilisation of structured data solutions for electronic patient records, is improving access to data for research, service improvement and the reduction of clinical data gaps.

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Bhangu, A. A., J. A. S. Beard, and R. J. Grimer. "Should Soft Tissue Sarcomas be Treated at a Specialist Centre?" Sarcoma 8, no. 1 (2004): 1–6. http://dx.doi.org/10.1080/13577140410001679185.

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Objective. We have investigated whether there is evidence that patients with soft tissue sarcomas do better if treated in a specialist centre compared with district general hospitals.Patients. All patients diagnosed with soft tissue sarcomas who were residents of WMRHA between 1994 and 1996, with minimum follow up of 5 years, excluding head and neck or retroperitoneal tumors.Methods. We reviewed data from the Royal Orthopaedic Hospital Oncology Service (ROHOS) database and the Cancer Intelligence Unit (CIU) Database, with medial record review where necessary. Main outcome measures were local recurrence and overall survival.Results. A total of 260 patients were diagnosed as having STS over the 3-year period (incidence=1.62per 100000 per year): 37% of patients had the majority of treatment at the specialist centre under the care of three surgeons, whilst the other 63% were treated at a total of 38 different hospitals. The rate of local recurrence was 39% at the district general hospitals compared with 19% at the specialist centre despite the fact that tumours treated at the district hospitals were smaller and of lower grade. The most significant factors affecting survival were grade (high versus low) and depth of the tumour. Patients treated at the specialist centre had a small survival advantage after multivariate testing.Conclusion. Soft tissue sarcomas are rare. Centralization of treatment improves local control in all patients and survival in some. Appropriate mechanisms for ensuring that patients with soft tissue sarcomas are seen and treated at specialist centres should be developed.

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Journal articles on the topic 'Database centres'

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