Log in

Relevant bibliographies by topics / DCVAC / Journal articles

To see the other types of publications on this topic, follow the link: DCVAC.

Journal articles on the topic 'DCVAC'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'DCVAC.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Rob, Lukas, David Cibula, Pawel Knapp, et al. "Dendritic cell vaccine (DCVAC) combined with chemotherapy (CMT) in patients with newly diagnosed epithelial ovarian carcinoma (EOC) after primary debulking surgery (PDS): Biomarker exploratory analysis of a phase 2, open-label, randomized, multicenter trial." Journal of Clinical Oncology 39, no. 15_suppl (2021): 5521. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.5521.

Full text

Abstract:

5521 Background: Most patients with EOC relapse despite PDS and CMT. Autologous DCVAC can present tumor antigens to elicit a durable immune response. We hypothesized that adding DCVAC to CMT stimulates antitumor immunity and improves clinical outcomes. Methods: Key eligibility criteria were FIGO stage III EOC (serous, endometrioid, or mucinous), post-PDS with < 1 cm maximal residuum, no prior systemic therapy, and ECOG 0-2. In part 1, patients were randomized up to 6 weeks after PDS, 1:1:1, into arm A (A; DCVAC concomitant with CMT), arm B (B; DCVAC sequential after CMT), and arm C (C; CMT)

APA, Harvard, Vancouver, ISO, and other styles

2

Lou, Yanni, Liqun Jia, Qing Liu, et al. "Efficacy and safety of DCVAC/LuCa Treatment plus standard chemotherapy and TCM in patients with advanced non-small cell lung cancer: A single-arm phase II study." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21590-e21590. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21590.

Full text

Abstract:

e21590 Background: Lung cancer remains the leading cause of cancer-related death in China. DCVAC/LuCa is an active autologous cellular immunotherapy consisting of autologous DCs loaded with NSCLC antigens from NSCLC cell lines. SQFZ is a kind of TCM injection commonly uesed for NSCLC, made from Ginseng and Astragalus membranaceus. Intent of this study is to evaluate the efficacy and safety of DCVAC/LuCa plus chemotherapy and TCM in patients with advanced NSCLC and wild type driving gene(EGFR/ALK). Methods: This study consist of screening/leukapheresis/treatment/follow-up period. On the treatme

APA, Harvard, Vancouver, ISO, and other styles

3

Havel, Libor, Vitezslav Kolek, Milos Pesek, et al. "Dendritic-cell vaccine (DCVAC) with first-line chemotherapy in patients with stage IV NSCLC: Final analysis of phase II, open label, randomized, multicenter trial." Journal of Clinical Oncology 37, no. 15_suppl (2019): 9039. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9039.

Full text

Abstract:

9039 Background: Immunotherapy aiming the induction of tumor cell specific immune responses controlling the tumor growth, has emerged as a promising treatment modality in lung cancer(LuCa). Autologous DCVAC can present tumor antigens to elicit a durable immune response. We hypothesized that adding DCVAC to the standard of care chemotherapy (ct) could prolong overall survival (OS) and progression-free survival (PFS). Methods: This study evaluated the efficacy and safety of DCVAC/LuCa (active cellular immunotherapy based on dendritic cells) concomitantly added to ct (carboplatin/paclitaxel) - Ar

APA, Harvard, Vancouver, ISO, and other styles

4

Spisek, Radek, Michal Podrazil, Marek Babjuk, et al. "Phase I/II clinical trials of dendritic cell-based immunotherapy in patients with the biochemical relapse of the prostate cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): e16002-e16002. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e16002.

Full text

Abstract:

e16002 Background: In order to have the highest impact on the control of tumor growth, cancer immunotherapy should be initiated as early in the disease course as possible. In prostate cancer, the effect of cancer immunotherapy at the minimal residual disease stage can be evaluated in patients with the biochemical relapse detected by ultrasensitive PSA measurements. We performed a Phase I/II clinical trial of dendritic cell based immunotherapy in patients with the biochemical relaps of the prostate cancer. Methods: Patients with the prostate cancer in the biochemical failure after radical prost

APA, Harvard, Vancouver, ISO, and other styles

5

Podrazil, Michal, Daniela Rozkova, Jitka Fucikova, Stanislav Katina, Radek Spisek, and Jirina Bartunkova. "Combined chemoimmunotherapy of castrate-resistant prostate cancer with dendritic-cell based vaccine DCVAC/Pca." Journal of Clinical Oncology 32, no. 15_suppl (2014): 3095. http://dx.doi.org/10.1200/jco.2014.32.15_suppl.3095.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Spisek, Radek, Michal Podrazil, Ladislav Jarolim, et al. "Cancer immunotherapy of patients with the biochemical relapse of the prostate cancer using dendritic cell-based vaccine DCVAC/PCa." Journal of Clinical Oncology 32, no. 15_suppl (2014): 3099. http://dx.doi.org/10.1200/jco.2014.32.15_suppl.3099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Podrazil, Michal, Rudolf Horvath, Etienne Becht, et al. "Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer." Oncotarget 6, no. 20 (2015): 18192–205. http://dx.doi.org/10.18632/oncotarget.4145.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Beer, Tomasz M., Nicholas Vogelzang, Jiřina Bartůňková, et al. "Autologous dendritic cell immunotherapy (DCVAC/PCa) added to docetaxel chemotherapy in a Phase III trial (viable) in men with advanced (mCRPC) prostate cancer." Journal for ImmunoTherapy of Cancer 3, Suppl 2 (2015): P164. http://dx.doi.org/10.1186/2051-1426-3-s2-p164.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Havel, Libor, Vitezslav Kolek, Milos Pesek, et al. "P3.06-001 Phase I/II Study to Evaluate Safety and Efficacy DCVAC/LuCa with 1st Line Chemotherapy +/- Immune Enhancers vs Chemotherapy, Stage IV NSCLC." Journal of Thoracic Oncology 12, no. 1 (2017): S1424—S1425. http://dx.doi.org/10.1016/j.jtho.2016.11.2183.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Havel, Libor, Milada Zemanova, Milos Pesek, et al. "Dendritic-cell vaccine (DCVAC) with first line chemotherapy in patients with stage IV NSCLC primary analysis of phase 2, open-label, randomized, multicenter trial." Journal of Clinical Oncology 36, no. 15_suppl (2018): 9051. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.9051.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Ling, X., J. Xu, R. Zhong, H. Zhong, and B. Han. "101MO Efficacy and safety of DCVAC/LuCa with chemotherapy for patients with stage IV NSCLC: A prospective, open-label, single-arm, phase II study." Journal of Thoracic Oncology 16, no. 4 (2021): S752—S753. http://dx.doi.org/10.1016/s1556-0864(21)01943-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Cibula, David, Lukas Rob, Peter Mallmann, et al. "Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial." Gynecologic Oncology 162, no. 3 (2021): 652–60. http://dx.doi.org/10.1016/j.ygyno.2021.07.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Choi, Youngmin, Hyung-Sik Lee, Hyuk-Chan Kwon, et al. "A Phase I/II Trial of DCVac/IR® Dendritic Cell Immunotherapy Combined with Irradiation in Cases of Refractory Colorectal Cancer with Multiple Liver Metastases." Journal of the Korean Society for Therapeutic Radiology and Oncology 26, no. 2 (2008): 104. http://dx.doi.org/10.3857/jkstro.2008.26.2.104.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Zemanova, Milada, Marketa Cernovska, Libor Havel, et al. "Autologous dendritic cell-based immunotherapy (DCVAC/LuCa) and carboplatin/paclitaxel in advanced non-small cell lung cancer: A randomized, open-label, phase I/II trial." Cancer Treatment and Research Communications 28 (2021): 100427. http://dx.doi.org/10.1016/j.ctarc.2021.100427.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Vogelzang, Nicholas J., Tomasz M. Beer, Jirina Bartunkova, et al. "Autologous dendritic cell vaccination (DCVAC/PCa) added to docetaxel chemotherapy in a double-blind, randomized phase III trial (VIABLE) in men with advanced (mCRPC) prostate cancer." Journal of Clinical Oncology 33, no. 15_suppl (2015): TPS5070. http://dx.doi.org/10.1200/jco.2015.33.15_suppl.tps5070.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Rob, Lukas, Jirina Bartunkova, David Cibula, et al. "Autologous dendritic cell vaccination (DCVAC/OvCa) added to standard of care therapy in three open-label randomized phase 2 studies in women with advanced stage ovarian cancer (OC)." Journal of Clinical Oncology 32, no. 15_suppl (2014): TPS3134. http://dx.doi.org/10.1200/jco.2014.32.15_suppl.tps3134.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Zhong, H., R. Zhong, and B. Yan. "A randomized study to evaluate safety of DCVAC/LUCA added to chemotherapy with carboplatin and pemetrexed vs. chemotherapy alone in patients with stage IV non-small cell lung cancer." Annals of Oncology 28 (April 2017): ii42. http://dx.doi.org/10.1093/annonc/mdx091.036.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Cibula, D., L. Rob, P. Mallmann, et al. "Dendritic cell-based immunotherapy (DCVAC/OvCa) with chemotherapy in patients with platinum-sensitive, relapsed, epithelial ovarian carcinoma: Survival analysis of a phase II, open-label, randomized, multicenter trial (study SOV02)." Gynecologic Oncology 154 (June 2019): 18. http://dx.doi.org/10.1016/j.ygyno.2019.04.046.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Rob, Lukas, Peter Mallmann, Pawel Knapp, et al. "Dendritic cell vaccine (DCVAC) with chemotherapy (ct) in patients (pts) with epithelial ovarian carcinoma (EOC) after primary debulking surgery (PDS): Interim analysis of a phase 2, open-label, randomized, multicenter trial." Journal of Clinical Oncology 36, no. 15_suppl (2018): 5509. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.5509.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Fucikova, Jitka, Michal Podrazil, Ladislav Jarolim, et al. "Phase I/II trial of dendritic cell-based active cellular immunotherapy with DCVAC/PCa in patients with rising PSA after primary prostatectomy or salvage radiotherapy for the treatment of prostate cancer." Cancer Immunology, Immunotherapy 67, no. 1 (2017): 89–100. http://dx.doi.org/10.1007/s00262-017-2068-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Nowak, Graz˙yna, Kenneth B. Keasler, Douglas E. McKeller, and Rick G. Schnellmann. "Differential effects of EGF on repair of cellular functions after dichlorovinyl-l-cysteine-induced injury." American Journal of Physiology-Renal Physiology 276, no. 2 (1999): F228—F236. http://dx.doi.org/10.1152/ajprenal.1999.276.2.f228.

Full text

Abstract:

This study examined the repair of renal proximal tubule cellular (RPTC) functions following sublethal injury induced by the nephrotoxicant S-(1,2-dichlorovinyl)-l-cysteine (DCVC). DCVC exposure resulted in 31% cell death and loss 24 h following the treatment. Monolayer confluence recovered through migration/spreading but not proliferation after 6 days. Basal, uncoupled, and ouabain-sensitive oxygen consumption (Qo 2) decreased 47, 76, and 62%, respectively, 24 h after DCVC exposure. Na+-K+-ATPase activity and Na+-dependent glucose uptake were inhibited 80 and 68%, respectively, 24 h after DCVC

APA, Harvard, Vancouver, ISO, and other styles

22

Redactie. "Over de DCVA." De Cardioloog 4, no. 4 (2020): 8. http://dx.doi.org/10.24078/cardio.2020.8.125743.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Liu, Xiuli, Malinda L. Godwin та Grażyna Nowak. "Protein kinase C-α inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-l-cysteine injury in renal cells". American Journal of Physiology-Renal Physiology 287, № 1 (2004): F64—F73. http://dx.doi.org/10.1152/ajprenal.00216.2003.

Full text

Abstract:

Previously, we showed that physiological functions of renal proximal tubular cells (RPTC) do not recover following S-(1,2-dichlorovinyl)-l-cysteine (DCVC)-induced injury. This study investigated the role of protein kinase C-α (PKC-α) in the lack of repair of mitochondrial function in DCVC-injured RPTC. After DCVC exposure, basal oxygen consumption (Qo2), uncoupled Qo2, oligomycin-sensitive Qo2, F1F0-ATPase activity, and ATP production decreased, respectively, to 59, 27, 27, 57, and 68% of controls. None of these functions recovered. Mitochondrial transmembrane potential decreased 53% after DCV

APA, Harvard, Vancouver, ISO, and other styles

24

Zhan, Y., J. L. Cleveland, and J. L. Stevens. "A role for c-myc in chemically induced renal-cell death." Molecular and Cellular Biology 17, no. 11 (1997): 6755–64. http://dx.doi.org/10.1128/mcb.17.11.6755.

Full text

Abstract:

A variety of genes, including c-myc, are activated by chemical toxicants in vivo and in vitro. Although enforced c-myc expression induces apoptosis after withdrawing survival factors, it is not clear if activation of the endogenous c-myc gene is an apoptotic signal after toxicant exposure. The renal tubular epithelium is a target for many toxicants. c-myc expression is activated by tubular damage. In quiescent LLC-PK1 renal epithelial cells, c-myc but not max or mad mRNA is induced by the nephrotoxicant S-(1,2-dichlorovinyl)-L-cysteine (DCVC). The kinetics of DCVC-induced c-myc expression and

APA, Harvard, Vancouver, ISO, and other styles

25

Regola, F., A. Tincani, F. Franceschini, and P. Toniati. "FRI0217 SENSITIVITY AND SPECIFICITY OF 2019 DCVAS DRAFT CLASSIFICATION CRITERIA FOR GIANT CELLS ARTERITIS AND TAKAYASU ARTERITIS IN A MONOCENTRIC COHORT OF PATIENTS WITH CLINICAL DIAGNOSIS OF LARGE VESSEL VASCULITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 692.2–692. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3375.

Full text

Abstract:

Background:Recently, a new set of classification criteria for Giant Cells Arteritis (GCA) and Takayasu Arteritis (TA) has been developed by the DCVAS project and presented as draft criteria at the 19th International Vasculitis and ANCA Workshop held in Philadelphia in 2019.Objectives:The purpose of the present study is to analyze the performance of the 2019 DCVAS Draft Classification Criteria in differentiating GCA and TA in a cohort of patients with Large Vessel Vasculitis (LVV), comparing their sensitivity and specificity to 1990 ACR Classification Criteria.Methods:2019 DCVAS Draft Criteria

APA, Harvard, Vancouver, ISO, and other styles

26

Banerjee, Nivedita, Hui Wang, Gangduo Wang, and M. Firoze Khan. "Enhancing the Nrf2 Antioxidant Signaling Provides Protection Against Trichloroethene-mediated Inflammation and Autoimmune Response." Toxicological Sciences 175, no. 1 (2020): 64–74. http://dx.doi.org/10.1093/toxsci/kfaa022.

Full text

Abstract:

Abstract Trichloroethene (trichloroethylene, TCE) and one of its reactive metabolites dichloroacetyl chloride (DCAC) are associated with the induction of autoimmunity in MRL+/+ mice. Although oxidative stress plays a major role in TCE-/DCAC-mediated autoimmunity, the underlying molecular mechanisms still need to be delineated. Nuclear factor (erythroid-derived 2)-like2 (Nrf2) is an oxidative stress-responsive transcription factor that binds to antioxidant responsive element (ARE) and provides protection by regulating cytoprotective and antioxidant gene expression. However, the potential of Nrf

APA, Harvard, Vancouver, ISO, and other styles

27

Andel, P., S. Brådland, A. Diamandopoulos, G. Myklebust, and G. Haugeberg. "AB0381 VALIDATING DRAFT DCVAS CRITERIA IN A SINGLE CENTER GCA COHORT IN SOUTHERN NORWAY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1218.1–1218. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4128.

Full text

Abstract:

Background:Giant cell arteritis (GCA) is the most common medium- and large vessel vasculitis in the elderly population. The diagnostic algorithm has changed in recent years in many institutions from temporal artery biopsy (TAB) to imaging based diagnosis (1). However, classification criteria that relied on TAB remained unchanged since 1990 (2). Reflecting the recent change in practice the Diagnostic and Classification Criteria for Vasculitis Study (DCVAS) group presented a draft classification criteria set for GCA. Endorsement by major scientific societies is currently pending (3).Objectives:T

APA, Harvard, Vancouver, ISO, and other styles

28

Cibula, David, Peter Mallmann, Pawel Knapp, et al. "Dendritic cell vaccine (DCVAC) with chemotherapy (ct) in patients (pts) with recurrent epithelial ovarian carcinoma (EOC) after complete response (CR) to 1st-line platinum (Pt)-based ct: Primary analysis of a phase 2, open-label, randomized, multicenter trial." Journal of Clinical Oncology 36, no. 15_suppl (2018): e17515-e17515. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.e17515.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Van Duuren, B. L., S. Melchionne, and I. Seidman. "Carcinogenicity of Acylating Agents: Chronic Bioassays in Mice and Structure-Activity Relationships (SARC)." Journal of the American College of Toxicology 6, no. 4 (1987): 479–87. http://dx.doi.org/10.3109/10915818709075693.

Full text

Abstract:

A small number of acylating agents are known to be carcinogenic. The structure-activity relationships and carcinogenicity (SARC) of these compounds are reviewed in this report. In addition, the results of chronic bioassays of three previously untested compounds are described. Female ICR/Ha Swiss mice, 30–50 per group, were used in all tests. The test duration was 18–22 months. Diethylcarbamyl chloride (DECC), ethyl chloroformate (ECF), and dichloroacetyl chloride (DCAC) were tested by repeated skin application, in two-stage carcinogenesis with phorbol myristate acetate (PMA) as promoter, and b

APA, Harvard, Vancouver, ISO, and other styles

30

Otieno, M. A., and M. W. Anders. "Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells." American Journal of Physiology-Renal Physiology 273, no. 1 (1997): F136—F143. http://dx.doi.org/10.1152/ajprenal.1997.273.1.f136.

Full text

Abstract:

Activation of NF-kappa B by the nephrotoxic and cytotoxic cysteine S-conjugate S-(1,2-dichlorovinyl)-L-cysteine (DCVC) was investigated in porcine kidney-derived LLC-PK1 cells. DCVC induced binding of nuclear proteins to an NF-kappa B consensus oligonucleotide from the immunoglobulin kappa-light chain enhancer region, as determined by electrophoretic mobility shift assays, and the activated proteins were identified as the p50/RelA heterodimeric complex of NF-kappa B. Transient transfection experiments with a kappa B-controlled luciferase reporter construct showed that the NF-kappa B complex ac

APA, Harvard, Vancouver, ISO, and other styles

31

Angelotti-Mendonça, Jéssika, Meire M. Bassan, João Paulo R. Marques, et al. "Knockdown of calreticulin, laccase, and Snf7 Genes Through RNAi Is Not Effective to Control the Asian Citrus Psyllid (Hemiptera: Livideae)." Journal of Economic Entomology 113, no. 6 (2020): 2931–40. http://dx.doi.org/10.1093/jee/toaa240.

Full text

Abstract:

Abstract The Asian citrus psyllid, Diaphorina citri Kuwayama, transmits the bacteria Candidatus Liberibacter associated with huanglongbing (HLB), a devastating disease of the citrus industry. The use of genetically modified plants is an alternative to control this vector. Conversely, technology based on RNA interference (RNAi) for silencing specific genes of a target insect could be attempted. This work evaluated the knockdown effect of the target genes calreticulin (DcCRT), laccase (DcLAC), and Snf7 (DcSnf7) by RNAi through feeding D. citri in Murraya paniculata leaves after the uptake of an

APA, Harvard, Vancouver, ISO, and other styles

32

Van de Water, B., M. Kruidering, and J. F. Nagelkerke. "F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells." American Journal of Physiology-Renal Physiology 270, no. 4 (1996): F593—F603. http://dx.doi.org/10.1152/ajprenal.1996.270.4.f593.

Full text

Abstract:

The mechanism of nephrotoxin-induced apoptosis was studied in rat renal proximal tubular cells (PTC) exposed to the nephrotoxin S-(1,2-dichlorovinyl)-L-cysteine (DCVC). After a 6-h incubation, DCVC caused a condensation of heterochromatin and a fragmentation of the nucleus in 84 and 16% of the cells, respectively, which is indicative of apoptosis. This was confirmed biochemically by agarose gel electrophoresis demonstrating the formation of DNA fragments with multiples of 200 bp. The antioxidant N,N'-diphenyl-p-phenylenediamine prevented neither the fragmentation of the nucleus nor the formati

APA, Harvard, Vancouver, ISO, and other styles

33

Nony, Paul A., Grazyna Nowak, and Rick G. Schnellmann. "Collagen IV promotes repair of renal cell physiological functions after toxicant injury." American Journal of Physiology-Renal Physiology 281, no. 3 (2001): F443—F453. http://dx.doi.org/10.1152/ajprenal.2001.281.3.f443.

Full text

Abstract:

Collagen IV is found in the renal proximal tubular cell (RPTC) basement membrane and is a mediator of renal development and function. Pharmacological concentrations ofl-ascorbic acid phosphate (AscP) promote the repair of physiological functions in RPTC sublethally injured by S-(1,2-dichlorovinyl)-l-cysteine (DCVC). We hypothesized that AscP promotes RPTC repair by stimulating collagen IV synthesis and/or deposition. RPTC exhibited increased synthesis but decreased deposition of collagen IV after DCVC exposure. In contrast, RPTC cultured in pharmacological concentrations of AscP maintained col

APA, Harvard, Vancouver, ISO, and other styles

34

Shaik, Zabeena P., E. Kim Fifer, and Grażyna Nowak. "Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells." American Journal of Physiology-Renal Physiology 292, no. 1 (2007): F292—F303. http://dx.doi.org/10.1152/ajprenal.00082.2006.

Full text

Abstract:

Protein kinase B (Akt) activation is well known for its protective effects against apoptosis. However, the role of Akt in regulation of necrosis is unknown. This study was designed to test whether Akt activation protects against nephrotoxicant-induced injury and death in renal proximal tubular cells (RPTC). Exposure of primary cultures of RPTC to the nephrotoxic cysteine conjugate, S-(1,2-dichlorovinyl)-l-cysteine (DCVC), resulted in 9% apoptosis and 30% necrosis at 24 h following the exposure. Akt was activated during 8 h but not at 24 h following toxicant exposure. No RPTC necrosis was obser

APA, Harvard, Vancouver, ISO, and other styles

35

Ramos, Isaac C., Bernardo T. Lopes, Fernando Faria-Correia, Bruno de Freitas Valbon, Michael Wellington Belin, and Renato Ambrósio. "Correlation of Topometric and Tomographic Indices with Visual Acuity in Patients with Keratoconus." International Journal of Keratoconus and Ectatic Corneal Diseases 1, no. 3 (2012): 167–72. http://dx.doi.org/10.5005/jp-journals-10025-1032.

Full text

Abstract:

ABSTRACT Purpose To evaluate the correlations of Pentacam keratometric, topometric (derived from front surface curvature) and tomographic (derived from 3D corneal shape analysis) indices with best corrected visual acuity in patients with keratoconus. Materials and methods One eye randomly selected of 123 patients with bilateral keratoconus was retrospectively enrolled. All patients underwent a comprehensive ophthalmic examination including subjective refraction, distance best-spectacle corrected visual acuity (DCVA) measurement, and rotating Scheimpflug corneal tomography (Pentacam HR; Oculus,

APA, Harvard, Vancouver, ISO, and other styles

36

Bosch, Marnix, Linda Liau, and Keyoumars Ashkan. "787 Phase III clinical trial to test the safety and efficacy of autologous tumor lysate-loaded dendritic cells in patients with newly diagnosed glioblastoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A836. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0787.

Full text

Abstract:

BackgroundGlioblastoma (GBM) is an incurable form of brain cancer with a high mortality rate in which multiple treatment attempts over the past decade have proven unsuccessful at extending survival. Early stage data have suggested that immunization against tumor cell antigens may be effective in GBM. In this Phase 3 study we aimed to assess whether autologous dendritic cells (DCs) loaded with autologous tumor cell lysate, is able to improve survival in these patients.MethodsWe conducted a randomized, double-blind, placebo-controlled international Phase 3 clinical trial with autologous tumor ly

APA, Harvard, Vancouver, ISO, and other styles

37

Van de Water, B., J. J. Jaspers, D. H. Maasdam, G. J. Mulder, and J. F. Nagelkerke. "In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function." American Journal of Physiology-Renal Physiology 267, no. 5 (1994): F888—F899. http://dx.doi.org/10.1152/ajprenal.1994.267.5.f888.

Full text

Abstract:

We investigated the relationship between F-actin damage and cell detachment using nephrotoxic L-cysteine S-conjugates. In vivo S-(1,2-dichlorovinyl)-L-cysteine (DCVC) induced loss of F-actin in the S3 segment of the proximal tubule in the outer stripe of the outer medulla, which was associated with loss of the brush border and loss of cells from the basement membrane. In vitro DCVC caused the detachment of primary cultured rat renal proximal tubular cells (PTC), which was clearly associated with F-actin damage. Disorganization of F-actin correlated with an increase in cellular levels of G-acti

APA, Harvard, Vancouver, ISO, and other styles

38

Korrapati, Midhun C., Edward A. Lock, and Harihara M. Mehendale. "Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-l-cysteine-induced acute renal failure and death." American Journal of Physiology-Renal Physiology 289, no. 1 (2005): F175—F185. http://dx.doi.org/10.1152/ajprenal.00418.2004.

Full text

Abstract:

Sustained activation of ERK 1/2 by a low dose (15 mg/kg ip) of S-1,2-dichlorovinyl-l-cysteine (DCVC) 72 h before administration of a lethal dose of DCVC (75 mg/kg ip) enhances renal cell division and protects mice against acute renal failure (ARF) and death (autoprotection). The objective of this study was to determine correlation among extent of S-phase DNA synthesis, activation of transcription factors, expression of G1/S cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors downstream of ERK 1/2 following DCVC-induced ARF in autoprotection. Administration of the lethal dose alone cau

APA, Harvard, Vancouver, ISO, and other styles

39

Polyzoidis, Stavros, and Keyoumars Ashkan. "DCVax®-L—Developed by Northwest Biotherapeutics." Human Vaccines & Immunotherapeutics 10, no. 11 (2014): 3139–45. http://dx.doi.org/10.4161/hv.29276.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Korrapati, Midhun C., Jaya Chilakapati, Edward A. Lock, John R. Latendresse, Alan Warbritton, and Harihara M. Mehendale. "Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-l-cysteine-induced acute renal failure and death in mice." American Journal of Physiology-Renal Physiology 291, no. 2 (2006): F439—F455. http://dx.doi.org/10.1152/ajprenal.00384.2005.

Full text

Abstract:

Previous studies have shown that renal injury initiated by a lethal dose of S-1,2-dichlorovinyl-l-cysteine (DCVC) progresses due to inhibition of cell division and hence renal repair, leading to acute renal failure (ARF) and death in mice. Renal injury initiated by low to moderate doses of DCVC is repaired by timely and adequate stimulation of renal cell division, tubular repair, restoration of renal structure and function leading to survival of mice. Recent studies have established that mice primed with a low dose of DCVC (15 mg/kg ip) 72 h before administration of a normally lethal dose (75

APA, Harvard, Vancouver, ISO, and other styles

41

Shaik, Zabeena P., E. Kim Fifer, and Grażyna Nowak. "Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury." American Journal of Physiology-Renal Physiology 294, no. 2 (2008): F423—F432. http://dx.doi.org/10.1152/ajprenal.00463.2007.

Full text

Abstract:

Previously, we showed that protein kinase B (Akt) activation increases intracellular ATP levels and decreases necrosis in renal proximal tubular cells (RPTC) injured by the nephrotoxicant S-(1, 2-dichlorovinyl)-l-cysteine (DCVC) (Shaik ZP, Fifer EK, Nowak G. Am J Physiol Renal Physiol 292: F292–F303, 2007). This study examined the role of Akt in improving mitochondrial function in DCVC-injured RPTC. Our data show a novel observation that phosphorylated (active) Akt is localized in mitochondria of noninjured RPTC, both in mitoplasts and the mitochondrial outer membrane. Mitochondrial levels of

APA, Harvard, Vancouver, ISO, and other styles

42

Thomas-Orillard, M., B. Jeune, and G. Cusset. "Drosophila-host genetic control of susceptibility to Drosophila C virus." Genetics 140, no. 4 (1995): 1289–95. http://dx.doi.org/10.1093/genetics/140.4.1289.

Full text

Abstract:

Abstract Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "partially tolerant". Isofemale lines obtained from one susceptible and one partially tolerant strain were studied. The partially tolerant phenotype was dominant, and there was no difference between F1 progeny of direct and reciprocal crosses. Analysis of F2 progeny showed that

APA, Harvard, Vancouver, ISO, and other styles

43

MacCall, Alec D. "Depletion-corrected average catch: a simple formula for estimating sustainable yields in data-poor situations." ICES Journal of Marine Science 66, no. 10 (2009): 2267–71. http://dx.doi.org/10.1093/icesjms/fsp209.

Full text

Abstract:

Abstract MacCall, A. D. 2009. Depletion-corrected average catch: a simple formula for estimating sustainable yields in data-poor situations. – ICES Journal of Marine Science, 66: 2267–2271. The depletion-corrected average catch (DCAC) formula is an extension of the potential-yield formula, and it provides useful estimates of sustainable yield for data-poor fisheries on long-lived species. Over an extended period (e.g. a decade or more), the catch is divided into a sustainable yield component and an unsustainable “windfall” component associated with a one-time reduction in stock biomass. The si

APA, Harvard, Vancouver, ISO, and other styles

44

Maçaneiro, Marcial, Jefferson Zeferino, and Vitor Hugo Lourenço. "O testemunho da Graça no contexto da comemoração da Reforma: perspectivas práticas do diálogo católico-luterano." Estudos Teológicos 58, no. 2 (2018): 407. http://dx.doi.org/10.22351/et.v58i2.3113.

Full text

Abstract:

O presente artigo, no horizonte dos 500 anos da Reforma, pensa perspectivas práticas do ecumenismo, em especial a partir do diálogo católico-luterano, mas também a partir de outras ressonâncias eclesiais, como a tradição reformada. Desta forma, apresenta-se o documento Do Conflito à Comunhão (DCAC) em sua constituição teórica, identificando-se a graça como moldura teológica do texto. A partir disso, elabora-se uma recepção católica e protestante, também como forma de contribuição e alargamento da noção de gratuidade expressa no DCAC. Com isso, a Exortação Apostólica Evangelii Gaudium (EG) e as

APA, Harvard, Vancouver, ISO, and other styles

45

&NA;. "A personalised brain cancer vaccine* [DCVax-Brain] appears promising,." Inpharma Weekly &NA;, no. 1537 (2006): 6. http://dx.doi.org/10.2165/00128413-200615370-00012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Yazlle Rocha, Juan Stuardo, Alzira de Oliveira Jorge, Breno José G. Simões, and Fábio Leite Vichi. "Desigualdades entre pacientes hospitalizados por doenças cardíacas e vasculares-cerebrais em localidade do Estado de São Paulo (Brasil), 1986." Revista de Saúde Pública 23, no. 5 (1989): 374–81. http://dx.doi.org/10.1590/s0034-89101989000500003.

Full text

Abstract:

Valendo-se de um sistema de informações sobre hospitalizações no Município de Ribeirão Preto, SP (Brasil) foram estudadas as características clínico-epidemiológicas referidas dos pacientes internados, em 1986, por doenças cardíacas e vasculares-cerebrais (DCVC). De 43.499 hospitalizações ocorridas naquele ano, 4.673 foram ocasionadas por doenças cardíacas e vasculares-cerebrais. Utilizando a fonte de financiamento da internação como indicador do estrato social ao qual pertence o paciente, foram compostos 4 grupos de estudo: particulares, "outros", previdenciários e "não pagantes"; estes grupos

APA, Harvard, Vancouver, ISO, and other styles

47

Korrapati, Midhun C., Jaya Chilakapati, Frank A. Witzmann, Chundury Rao, Edward A. Lock, and Harihara M. Mehendale. "Proteomics ofS-(1, 2-dichlorovinyl)-l-cysteine-induced acute renal failure and autoprotection in mice." American Journal of Physiology-Renal Physiology 293, no. 4 (2007): F994—F1006. http://dx.doi.org/10.1152/ajprenal.00114.2007.

Full text

Abstract:

Previous studies (Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Toxicol Sci 74: 215–227, 2003; Korrapati MC, Lock EA, Mehendale HM. Am J Physiol Renal Physiol 289: F175–F185, 2005; Korrapati MC, Chilakapati J, Lock EA, Latendresse JR, Warbritton A, Mehendale HM. Am J Physiol Renal Physiol 291: F439–F455, 2006) demonstrated that renal repair stimulated by a low dose of S-(1,2-dichlorovinyl)l-cysteine (DCVC; 15 mg/kg ip) 72 h before administration of a normally lethal dose (75 mg/kg ip) protects mice from acute renal failure (ARF) and death (autoprotection). The present study identified

APA, Harvard, Vancouver, ISO, and other styles

48

Santos, Rodrigo, Renata Siqueira, Bruno Valbon, Daniel Dawson, Luis claudio Pereira, and Jorge Augusto Siqueira. "Long-term Improvement after the Athens Protocol for Advanced Keratoconus with Significant Ectasia Progression in the Fellow Eye." International Journal of Keratoconus and Ectatic Corneal Diseases 3, no. 1 (2014): 40–43. http://dx.doi.org/10.5005/jp-journals-10025-1076.

Full text

Abstract:

ABSTRACT To describe the long-term result of the Athens protocol (custom topography-guided advanced surface ablation followed by riboflavin-UVA collagen cross-linking in the same day) for progressive advanced keratoconus in the left eye, while the fellow right eye first presented with relatively mild keratoconus that was treated with a more conservative therapeutic approach of continuous contact lenses use with the goal for ectasia stabilization. Five years after the Athens protocol, a regression of over 10D (diopters) was observed on the sagittal curvature with significant regularization of c

APA, Harvard, Vancouver, ISO, and other styles

49

Wheeler, Christopher J., and Keith L. Black. "DCVax®-Brain and DC vaccines in the treatment of GBM." Expert Opinion on Investigational Drugs 18, no. 4 (2009): 509–19. http://dx.doi.org/10.1517/13543780902841951.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

EDWARDS, Clare M., Janice M. MARSHALL, and M. PUGH. "Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin." Clinical Science 96, no. 6 (1999): 577–88. http://dx.doi.org/10.1042/cs0960577.

Full text

Abstract:

In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response habituates on repetition of the sound stimulus in control subjects, both cutaneous vasoconstriction and muscle dilatation persist in subjects with primary Raynaud's disease. The aim of the present study was to test whether a similar disparity exists between control subjects and those with primary Raynaud's disease for the response to mild cool stimul

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!