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Journal articles on the topic 'Definitive Study Design'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Jones, Bradley, and Maria Lanzerath. "A novel application of a definitive screening design: A case study." Quality Engineering 33, no. 3 (2021): 563–69. http://dx.doi.org/10.1080/08982112.2021.1892758.

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Priyanka, Lekhwar, P. K. Sahoo Dr., and Agarwal |. Amit Sharma Ravindra. "Development of Gastroretentive Floating Tablets Quetiapine Fumarate." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1037–40. https://doi.org/10.31142/ijtsrd24051.

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The idea of the study is to prepare and characterize a sustain release floating tablets of Quetiapine Fumarate for Schizophrenia. Materials which are used in making of effervescent Tablets are hydroxy methylcellulose HPMC. For the buoyancy sodium bicarbonate is used. Initially for the selection of formulation Definitive screening design is used which allows to study the effect of large number of factors in relatively small experiment. The optimized formulation is tested for release rate, buoyancy, hardness, thickness, floating time, swelling study and release rate. These studies shows that opt

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Shah, Manish A., Jaafar Bennouna, Toshihiko Doi, et al. "KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma." Future Oncology 17, no. 10 (2021): 1143–53. http://dx.doi.org/10.2217/fon-2020-0969.

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Despite curative-intent treatment, most patients with locally advanced esophageal cancer will experience disease recurrence or locoregional progression, highlighting the need for new therapies. Current guidelines recommend definitive chemoradiotherapy in patients ineligible for surgical resection, but survival outcomes are poor. Pembrolizumab is well tolerated and provides promising antitumor activity in patients with previously treated, advanced, unresectable esophageal/esophagogastric junction cancer. Combining pembrolizumab with chemoradiotherapy may further improve outcomes in the first-li

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Roschan, MD, Suwat. "Clinical Study of a New Design Percutaneous Transpedicular Biopsy System for Spinal Tuberculosis." Journal of Southeast Asian Orthopaedics 46, no. 1 (2022): 24–28. http://dx.doi.org/10.56929/jseaortho.v46i1.9.

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Purpose: Despite some spinal tuberculosis cases having typical imaging findings, histological/ microbiological evidence is required for definitive diagnosis and management. Percutaneous biopsy is suitable for histopathologic and bacteriologic evaluation of vertebral lesions, as it is a quick and minimally invasive technique to obtain specimens from deep structures and is advantageous for open surgical biopsy. Based on a minimally invasive technique, herein, we describe a newly designed percutaneous transpedicular biopsy system for lumbar vertebral lesion biopsy. Methods: Fifty-six patients who

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Cavarzere, Paolo, Rossella Gaudino, Marco Sandri, et al. "Growth hormone retesting during puberty: a cohort study." European Journal of Endocrinology 182, no. 6 (2020): 559–67. http://dx.doi.org/10.1530/eje-19-0646.

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Objectives To report the frequency and characteristics of growth hormone (GH) deficiency (GHD) in adolescents who had normalized GH secretion at mid-puberty and to identify possible factors predictive for GH sufficiency at puberty. Design Clinical analysis of children affected by GHD at five time points: diagnosis; first year of therapy; intermediate stage of puberty; retesting and end of growth phase. Methods The study population was 80 children with idiopathic GHD and treated with GH for at least 2 years. Treatment was discontinued at the intermediate stage of puberty. Retesting with an argi

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McAllister, Jan, Sally Gascoine, Amy Carroll, et al. "Cognitive bias modification for social anxiety in adults who stutter: a feasibility study of a randomised controlled trial." BMJ Open 7, no. 10 (2017): e015601. http://dx.doi.org/10.1136/bmjopen-2016-015601.

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ObjectiveTo determine the feasibility and acceptability of a computerised treatment for social anxiety disorder for adults who stutter including identification of recruitment, retention and completion rates, large cost drivers and selection of most appropriate outcome measure(s) to inform the design of a future definitive trial.DesignTwo-group parallel design (treatment vs placebo), double-blinded feasibility study. Participants: 31 adults who stutter.InterventionAttention training via an online probe detection task in which the stimuli were images of faces displaying neutral and disgusted exp

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Park, Young-Seok, Seung-Pyo Lee, Chong-Hyun Han, Joo Hyun Kwon, and Young-Chul Jung. "The Microtomographic Evaluation of Marginal Bone Resorption of Immediately Loaded Scalloped Design Implant With Various Microthread Configurations in Canine Mandible: Pilot Study." Journal of Oral Implantology 36, no. 5 (2010): 357–62. http://dx.doi.org/10.1563/aaid-joi-d-09-00041.

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Abstract This study was undertaken to evaluate the effect of microthread geometry of scalloped design implant on marginal bone resorption. Four types of scalloped design titanium implant specimens were prepared. The type 1 implant had a machined scalloped collar, type 2 had a sandblasted and acid-etched scalloped collar, type 3 had horizontal microthreads, and type 4 had parabolic microthreads, which are parallel with the scalloped conical margin. Two implants of a type were randomly installed immediately after extraction in the mandible of a beagle dog. Definitive prostheses were delivered im

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Hitchcock, Ying J., Brandon G. Bentz, Pramod K. Sharma, et al. "Planned Neck Dissection after Definitive Radiotherapy or Chemoradiation for Base of Tongue Cancers." Otolaryngology–Head and Neck Surgery 137, no. 3 (2007): 422–27. http://dx.doi.org/10.1016/j.otohns.2007.03.008.

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OBJECTIVES: The study goal was to analyze the role of planned neck dissection for squamous cell carcinoma of the base of the tongue treated with definitive radiotherapy or chemoradiation. STUDY DESIGN, SETTING: We conducted a retrospective study of patients with squamous cell carcinoma of the base of the tongue undergoing planned neck dissection after definitive radiotherapy or chemoradiation. RESULTS: Twenty-two of 41 (53.7%) patients had one to six positive residual lymph nodes after receiving definitive radiotherapy or chemoradiation. Neck control rates were 92.3% and 88.3% at two and five

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Broderick, Lirong Z., Jonathan Moult, Oleg Rusch, Tong Tong, Tobias Erlbacher, and Yunji L. Corcoran. "Highly Efficient Floating Field Rings for SiC Power Electronic Devices - A Systematic Experimental Study." Key Engineering Materials 946 (May 25, 2023): 103–10. http://dx.doi.org/10.4028/p-0z5887.

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A systematic experimental study is conducted on floating field rings (FFR) incorporated into 4H-SiC junction barrier Schottky (JBS) diodes across four voltage ratings 650, 1200, 1700 and 3300V, in pursuit of highly efficient FFR designs. 30 designs of FFR in 3 categories are studied for each voltage rating, and the measured breakdown voltage (Vbr) of JBS divided by ring system width (W) is taken as the figure of merit (FOM) of each design. The influence of ring spacing, ring width and number of rings on Vbr is studied in detail. It is found that the initial ring spacing (S1) is critical in det

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Aramide, Kolawole Akinjide, Udeme Samuel Jacob, and Jace Pillay. "Conceptualisation and Contextualisation of Mixed-Methods Research: A Review." Research in Social Sciences and Technology 8, no. 4 (2023): 14–36. http://dx.doi.org/10.46303/ressat.2023.31.

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The purpose of this study was to investigate the conceptualisation and contextualisation of mixed-methods research within the research methodology paradigm to ascertain the categorisation of mixed methods as a type of research, research design or research approach. The methodology adopted for this paper is qualitative in nature and involves the analysis of documents and contents. The content of journals and books was analysed to review and draw inferences relating to the themes set out for investigation in the study. Thematic analysis was used for the analysis of data for the study. The study

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Al-Rasadi, Khalid, Khalid F. Alhabib, Faisal Al-Allaf, et al. "The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results." Current Vascular Pharmacology 18, no. 1 (2019): 57–64. http://dx.doi.org/10.2174/1570161116666181005125459.

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Aim: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. Methods: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. In phase 1, suspected FH patients (category 1) were collected according to the lipid profile and clinical data obtained through hospital record systems. In phase 2, patients from category 2 (patients with a previous clinical diagnosis of FH) and

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Giovanni, B.Frisoni, Barkhof Frederik, Altomare Daniele, et al. "AMYPAD Diagnostic and Patient Management Study: Rationale and design." Alzheimer's & Dementia 15, no. 3 (2018): 388–99. https://doi.org/10.1016/j.jalz.2018.09.003.

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<strong>Abstract</strong> <strong>Introduction: </strong>Reimbursement of amyloid-positron emission tomography (PET) is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. The Amyloid Imaging to Prevent Alzheimer's Disease-Diagnostic and Patient Management Study (AMYPAD-DPMS) is designed to fill this gap. <strong>Methods: </strong>AMYPAD-DPMS is a phase 4, multicenter, prospective, randomized controlled study. Nine hundred patients with subjective cognitive decline plus, mild cognitive impairment, and dementia possibly due to Alzheimer&#

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Takagaki, Keisuke, Terushi Ito, Hiroaki Arai, Yasuko Obata, Kozo Takayama, and Yoshinori Onuki. "The Usefulness of Definitive Screening Design for a Quality by Design Approach as Demonstrated by a Pharmaceutical Study of Orally Disintegrating Tablet." Chemical and Pharmaceutical Bulletin 67, no. 10 (2019): 1144–51. http://dx.doi.org/10.1248/cpb.c19-00553.

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V. B. T. Santhi, M., S. Sagar Imambi, J. Yamini Devi, and D. Tejaswani. "Design and development of information using keyword-element relationship graph - a critical study." International Journal of Engineering & Technology 7, no. 2.7 (2018): 1020. http://dx.doi.org/10.14419/ijet.v7i2.7.12211.

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These days there is a gigantic accumulation of information and content reports are present. So there is fundamental for comprehension the vast content gathering of data. To comprehend the huge content accumulation of information is currently more simple by finding a string might be a characteristic perfect model for looking for associated information sources on the net. We have a tendency to propose to course fundamental words essentially to uncommon sources to reduce the high cost of unequivocal word look questions over all sources. We have a tendency to use a watchword component relationship

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El-Shafie, Ahmed S., Areej W. Khashan, Yasser H. A. Hussein, and Marwa El-Azazy. "Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies." RSC Advances 9, no. 43 (2019): 24722–32. http://dx.doi.org/10.1039/c9ra03141c.

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A spectrochemical approach was adopted to study the charge-transfer (CT) complexation of sparfloxacin (SFX) with tetracyanoethylene (TCNE). Definitive screening design (DSD) was used to investigate the reaction variables.

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Tacail, François G., Barry Evans, and Alan Babb. "Case study of a labyrinth weir spillway." Canadian Journal of Civil Engineering 17, no. 1 (1990): 1–7. http://dx.doi.org/10.1139/l90-001.

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A labyrinth weir is an effective and economical means of providing increased spillway capacity under some restricted operating conditions. This type of weir is particularly suited to reservoir sites where a low head to high discharge relation is required, the topography restricts the spillway width, and a self-operating structure is highly desirable for emergency operation. Over the past few decades, labyrinth weir spillways have been constructed throughout the world. Definitive guidelines and theoretical procedures pertaining to hydraulic design of this type of weir are not completely establi

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Naderi, Jody Rosenblatt. "Landscape Design in Clear Zone: Effect of Landscape Variables on Pedestrian Health and Driver Safety." Transportation Research Record: Journal of the Transportation Research Board 1851, no. 1 (2003): 119–30. http://dx.doi.org/10.3141/1851-12.

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The relationship between landscape installations and safety or pedestrian activity was evaluated in pilot studies. The sites selected for study were those adjacent to or within the areas often referred to as the “clear zone” of the transportation corridor, an area shared by pedestrians and driver perception. Case study research on the impact of environmental mitigation on driver safety is summarized to identify the landscape installations in the clear zone that appear to have an effect on safety. This is followed by case study research on the identification of variables that encourage walking

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Levy, Eugene H., George D. Gatewood, and Richard J. Terrile. "The Astrometric Imaging Telescope: Near-Term Discovery and Study of Other Planetary Systems." International Astronomical Union Colloquium 123 (1990): 287. http://dx.doi.org/10.1017/s0252921100077150.

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AbstractThe Astrometric Imaging Telescope (AIT) is a space-based 1.5 to 2 meter diameter telescope designed to discover and study planetary systems around other stars. The measurement objectives and instrument design aim at a definitive search for other planetary systems. The science program includes two planetary-system investigations, and the telescope carries two separate instruments: an astrometric instrument to measure the reflex motions of stars caused by the motions of unseen planets and an imaging coronagraph to directly image planets and other circumstellar matter.

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Tomblyn, Marcie R., and J. Douglas Rizzo. "Are There Circumstances in Which Phase 2 Study Results Should Be Practice-Changing?" Hematology 2007, no. 1 (2007): 489–92. http://dx.doi.org/10.1182/asheducation-2007.1.489.

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Abstract New pharmaceuticals, innovative combinations of approved agents, and novel treatment modalities have resulted in a marked increase in the need for clinical trials. Evidence for treatment efficacy is best derived from large phase 3 randomized, controlled clinical trials. However, phase 3 investigations are lengthy and expensive, and consume patient resources. Furthermore, some diseases and treatment indications are rare, and adequate numbers of patients for a definitive phase 3 trial do not exist. Consequently, it is imperative for clinicians to understand phase 2 trial design, since t

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Brocklehurst, Paul, Zoe Hoare, Chris Woods, et al. "Dental therapists compared with general dental practitioners for undertaking check-ups in low-risk patients: pilot RCT with realist evaluation." Health Services and Delivery Research 9, no. 3 (2021): 1–118. http://dx.doi.org/10.3310/hsdr09030.

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Background Many dental ‘check-ups’ in the NHS result in no further treatment. The patient is examined by a dentist and returned to the recall list for a further check-up, commonly in 6 or 12 months’ time. As the oral health of regular dental attenders continues to improve, it is likely that an increasing number of these patients will be low risk and will require only a simple check-up in the future, with no further treatment. This care could be delivered by dental therapists. In 2013, the body responsible for regulating the dental profession, the General Dental Council, ruled that dental thera

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Siboy, Ahmad, Sholahuddin Al-Fatih, Devi Triasari, and Hilaire Tegnan. "Legal Social Justice in Appointment Non-Definitive Regional Heads toward Welfare State." BESTUUR 11, no. 1 (August) (2023): 144. http://dx.doi.org/10.20961/bestuur.v11i1.71055.

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<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p class="AbstractText">The process of resolving administrative violations in the appointment of non-definitive regional heads that have not been regulated can threaten democratic values. Likewise, there has not been a judicial institution that has been given special authority to try it. This study aims to provide a regulatory model or settlement of administrative violations in the appointment of non-definitive regional heads in the welfare state. This study is

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Angela Florida Mau and Stanislaus Digman Layan. "Bertolaklah Ke Tempat Lebih Dalam Menuju Paroki Definitif." Jurnal Budi Pekerti Agama Kristen dan Katolik 2, no. 1 (2024): 163–76. http://dx.doi.org/10.61132/jbpakk.v2i1.214.

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The Lauran Sacred Heart Quasi-Parish has held its first pastoral deliberation. This activity aims to provide an understanding of the direction of the pastoral vision of the Diocese of Amboina, reflect on the faith of the participants, and produce plans and recommendations for forming a definitive parish. This research is descriptive qualitative research carried out using the literature study method. The aim of the research is to provide an overview of church independence in relation to the pastoral vision of the Diocese of Amboina. The research results show that there is a relationship between

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Kuswandari, Yulianti. "Exploring the Link between Anisometropia, Binocular Vision Depth Perception, and Amblyopia in School-Aged Children: Insights from a Quantitative Study." Formosa Journal of Science and Technology 2, no. 5 (2023): 1373–86. http://dx.doi.org/10.55927/fjst.v2i5.4096.

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The study examined the relationship between anisometropia degree, binocular vision depth perception, and amblyopia in school-aged children. The research utilized a descriptive quantitative design at Dr. Soetomo Hospital Surabaya from November 2021 to January 2023. The findings indicated a correlation between anisometropia degree and binocular vision depth perception. As the refraction difference increased, the ability to perceive objects with three-dimensional vision diminished. However, no definitive correlation was found between anisometropia degree and amblyopia. To further explore these re

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Choi, Min Soo, and Ken Nah. "Establishing the Concept of Design Thinking Through Categorical Analysis." Korea Institute of Design Research Society 9, no. 4 (2024): 536–46. https://doi.org/10.46248/kidrs.2024.4.536.

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Design thinking should be viewed not as a fixed concept but as a flexible thought process that adapts to various situations and environments. This study aims to redefine the concept of design thinking using a categorical logic framework. Focusing on design as the 'Specific Difference' of design thinking, the research categorizes design concepts through affinity diagrams by visualizing various definitions. This highlights that design thinking is not a definitive tool tied to a specific model but a thought process that reflects design’s characteristics. The study proposes conceptualizing design

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Ismail, Muhammad, Rao Saad Ali Khan, Farrukh Saeed, and Muhammed Aasim Yusuf. "THE ROLE OF DIAGNOSTIC OESOPHAGO-GASTRODUODENOSCOPY (OGD) AND COLONOSCOPY IN CANCER OF UNKNOWN PRIMARY." PAFMJ 71, no. 6 (2021): 2166–69. http://dx.doi.org/10.51253/pafmj.v71i6.4090.

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Objective: To study the role of gastrointestinal procedures, namely oesophago-gastroduodenoscopy (OGD) and colonoscopy, in helping to establish a definitive primary tumour site in cancer of unknown primary. Study Design: Prospective observational study. Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore Pakistan, from Jan 2018 to Jan 2019. Methodology: A total of 115 patients included in the study were those, who underwent OGD and a colonoscopy for the diagnosis of a cancer of unknown primary. Data collected included demographic

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Nguyen Hai Le, Nam, Yuichi Sugai, and Kyuro Sasaki. "Investigation of Stability of CO2 Microbubbles—Colloidal Gas Aphrons for Enhanced Oil Recovery Using Definitive Screening Design." Colloids and Interfaces 4, no. 2 (2020): 26. http://dx.doi.org/10.3390/colloids4020026.

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CO2 microbubbles have recently been used in enhanced oil recovery for blocking the high permeability zone in heterogeneous reservoirs. Microbubbles are colloidal gas aphrons stabilized by thick shells of polymer and surfactant. The stability of CO2 microbubbles plays an important role in improving the performance of enhanced oil recovery. In this study, a new class of design of experiment (DOE)—definitive screening design (DSD) was employed to investigate the effect of five quantitative parameters: xanthan gum polymer concentration, sodium dodecyl sulfate surfactant concentration, salinity, st

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Naith, Qamar, and Fabio Ciravegna. "Definitive guidelines toward effective mobile devices crowdtesting methodology." International Journal of Crowd Science 4, no. 2 (2020): 209–28. http://dx.doi.org/10.1108/ijcs-01-2020-0002.

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Purpose This paper aims to gauge developers’ perspectives regarding the participation of the public and anonymous crowd testers worldwide, with a range of varied experiences. It also aims to gather their needs that could reduce their concerns of dealing with the public crowd testers and increase the opportunity of using the crowdtesting platforms. Design/methodology/approach An online exploratory survey was conducted to gather information from the participants, which included 50 mobile application developers from various countries with diverse experiences across Android and iOS mobile platform

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Spellman, Joseph, Ryan Sload, Paul Kim, Peter Martin, and Gabriel Calzada. "Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer." Otolaryngology–Head and Neck Surgery 158, no. 3 (2017): 479–83. http://dx.doi.org/10.1177/0194599817742615.

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Objective This study introduces a treatment algorithm based on staging neck dissection to identify patients with palatine tonsil squamous cell carcinoma who can be effectively treated with single-modality transoral robotic surgery while maintaining quality of life. Study Design Retrospective case series. Setting Kaiser Permanente Southern California Medical Group from 2012 to 2017. Subjects and Methods Patients with early-stage (T1/2) palatine tonsil squamous cell carcinoma with clinically and radiographically N0 necks underwent staging neck dissection. Those with pN2/3 disease or extracapsula

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Khan, Asfandyar, Sayed Najmul Hassan, Muhammad Farhan Farhat, Arsalan Riaz, Basit Mukhtar, and Akbar Ali. "External Fixation as a Primary and Definitive Treatment for Tibial Diaphyseal Fractures: a Retrospective Longitudinal Study." Pakistan Journal of Medical and Health Sciences 16, no. 1 (2022): 624–26. http://dx.doi.org/10.53350/pjmhs22161624.

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Aim:To assess the potency of unilateral external fixation as a proper cure for tibial fractures. Study design: A retrospective longitudinal study Place and duration: This study was conducted at Pakistan Institute of Medical Sciences (PIMS) Islamabad Pakistan from August 2020 to August 2021. Methodology:Treatment of 225 tibial shaft fractures was done, in which closed fractures took 22 weeks and open 26 weeks for complete fusion. All fractures were fixed with AO fixator Results:Data of 210 patients was evaluated. Treatment of 225 tibial shaft fractures was done, in which closed fractures took 2

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Flynn, Samantha, Richard P. Hastings, Christine Burke, et al. "Online Mindfulness Stress Intervention for Family Carers of Children and Adults with Intellectual Disabilities: Feasibility Randomized Controlled Trial." Mindfulness 11, no. 9 (2020): 2161–75. http://dx.doi.org/10.1007/s12671-020-01436-0.

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Abstract Objectives Family carers of people with intellectual disabilities (ID) are twice as likely as other carers to experience stress and mental ill-health, but research exploring interventions is sparse. Online mindfulness may provide an accessible, cost-effective resource. The addition of guided telephone support could help to tailor an existing intervention for this population. A feasibility randomized controlled trial (RCT) was conducted to inform the development of a definitive RCT. Methods Sixty participants were randomized to complete Be Mindful (a brief online mindfulness interventi

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Rabeea, Tahira Maira Larosh Saba Ramzan. "PERCUTANEOUS DRAINAGE FROM PERITONEAL CAVITY IN THE TREATMENT OF PERITONITIS: A SINGLE CENTRE STUDY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 07 (2019): 14125–29. https://doi.org/10.5281/zenodo.3275460.

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<em>Various factors resulting intestinal perforation including peptic ulcer perforations, ischemic colitis, intestinal obstruction, typhoid or TB infections, cancer, diverticulitis, trauma, and colonoscopy.  </em> <strong><em>Objective</em></strong><em>:  To determine the efficacy of percutaneous peritoneal drainage under local anesthesia in terms of morbidity and mortality</em> <strong><em>Study Design</em></strong><em>: Retrospective Study</em> <strong><em>Setting</em></strong><em>: The study was conducted in department of Surgery, Mayo Hospital, Lahore </em> <strong><em>Methodlogy

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Lee, Jessica, David Currow, Melanie Lovell, et al. "Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed-methods pilot study." BMJ Open 13, no. 2 (2023): e066125. http://dx.doi.org/10.1136/bmjopen-2022-066125.

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IntroductionMany patients experience unrelieved neuropathic cancer-related pain. Most current analgesic therapies have psychoactive side effects, lack efficacy data for this indication and have potential medication-related harms. The local anaesthetic lidocaine (lignocaine) has the potential to help manage neuropathic cancer-related pain when administered as an extended, continuous subcutaneous infusion. Data support lidocaine as a promising, safe agent in this setting, warranting further evaluation in robust, randomised controlled trials. This protocol describes the design of a pilot study to

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Hinckfuss, Simon, Heather J. Conrad, Lianshan Lin, Scott Lunos, and Wook-Jin Seong. "Effect of Surgical Guide Design and Surgeon's Experience on the Accuracy of Implant Placement." Journal of Oral Implantology 38, no. 4 (2012): 311–23. http://dx.doi.org/10.1563/aaid-joi-d-10-00046.

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Implant position is a key determinant of esthetic and functional success. Achieving the goal of ideal implant position may be affected by case selection, prosthodontically driven treatment planning, site preparation, surgeon's experience and use of a surgical guide. The combined effect of surgical guide design, surgeon's experience, and size of the edentulous area on the accuracy of implant placement was evaluated in a simulated clinical setting. Twenty-one volunteers were recruited to participate in the study. They were divided evenly into 3 groups (novice, intermediate, and experienced). Eac

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Watson, Megan, David Grande, Archana Radhakrishnan, Nandita Mitra, Katelyn R. Ward, and Craig Evan Pollack. "Racial Differences in Prostate Cancer Treatment: The Role of Socioeconomic Status." Ethnicity & Disease 27, no. 3 (2017): 201. http://dx.doi.org/10.18865/ed.27.3.201.

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<p><strong>Objective: </strong>This study examines whether socioeconomic status (SES), measured at both the individual and neighborhood levels, is associated with receipt of definitive treatment for localized prostate cancer and whether these associations mediate racial differences in treatment between non-Hispanic White and non-Hispanic Black men. </p><p><strong>Design: </strong>The Philadelphia Area Prostate Cancer Access Study (P2 Access) is a mailed, cross-sectional survey of men sampled from the Pennsylvania Cancer Registry, combined with neighbor

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Khachmafova, Zaineta, Tatiana Ostrovskaya, and Elena Skhalyakho. "The conceptual design of oil-and-gas metaphorical terms." E3S Web of Conferences 273 (2021): 11045. http://dx.doi.org/10.1051/e3sconf/202127311045.

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The article presents the stages and problems of conceptual design of metaphorical oil and gas terminology, which is rapidly developing in recent decades, so the purpose of the article is to define the principles of conceptual design of metaphorical terminology and to present some empirical evidence for this. The methodological basis of the article consists of methods that are widely used in linguistics: definitive and cognitive analysis, observation and description of linguistic facts. When considering the structural and semantic characteristics of metaphorical terms, the modeling method and t

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Eccles, Eamon, Yan Han, Hao Liu, et al. "EPID-11. ESTABLISHING A BASELINE TIME-FRAME FOR SYMPTOM ONSET TO DEFINITIVE DIAGNOSIS FOR CHILDREN WITH NEWLY-DIAGNOSED CNS TUMORS: AN EXPANDED, MULTI-INSTITUTIONAL COLLABORATIVE STUDY." Neuro-Oncology 22, Supplement_3 (2020): iii320—iii321. http://dx.doi.org/10.1093/neuonc/noaa222.197.

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Abstract BACKGROUND We have previously documented the presence of diagnostic delays in children with central nervous system (CNS) tumors in the United States. This study serves to expand and validate the previously established baseline from symptom onset to definitive diagnosis in children with newly-diagnosed CNS tumors. DESIGN: The medical records of children with newly-diagnosed CNS tumors were retrospectively reviewed from January 2004 to December 2017 at Nationwide Children’s Hospital, Akron Children’s Hospital and Riley Hospital for Children at IU Health. Records were reviewed for age, g

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Bunz, Oskar, Darja Iwantschenko, Sabrina Tulka, Claudia Barthel-Zimmer, and Andree Piwowarczyk. "Survival of Fiber-Reinforced Composite Resin Post-Restored vs. Cast Post-and-Core-Restored Teeth: A Retrospective Clinical Study." Oral 1, no. 4 (2021): 340–49. http://dx.doi.org/10.3390/oral1040034.

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Objective: The question of whether classic cast post-and-core (CPC) or fiber-reinforced composite resin posts (FRCP) are the best clinical decision has still not been fully solved. Materials and Methods: One hundred and sixty-two teeth were restored with FRCP, and 162 CPC restored teeth were included in this study with a matched-pair design. In a primary analysis, the survival rates after one year (primary endpoint) were compared. The additional analysis included an evaluation of tooth- and construction-specific variables and an illustration of the survival up to 60 months via Kaplan-Meier cur

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Sami, Asmara, Muhammad Ihtesham Khan, and Sami Iqbal. "Diagnostic utility of bone marrow aspiration biopsy in definitive diagnosis in cases of hepatosplenomegaly." Professional Medical Journal 28, no. 02 (2021): 214–17. http://dx.doi.org/10.29309/tpmj/2021.28.02.3928.

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Objective: To determine the diagnostic utility of bone marrow aspirate in finding cause of hepatosplenomegaly. Study Design: Cross Sectional Descriptive study. Setting: Pathology Department of Khyber Teaching Hospital. Period: August 2017 to December 2017. Material & Methods: A total of 116 cases were referred to Pathology department for workup of hepatosplenomegaly during study period. Patients were subjected to bone marrow aspiration and biopsy. The cases were diagnosis was made and those where no specific diagnosis could be made were noted. Mean and standard deviation were used for quan

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Freedland, Stephen J., Ugo De Giorgi, Martin Gleave, et al. "A phase 3 randomised study of enzalutamide plus leuprolide and enzalutamide monotherapy in high-risk non-metastatic hormone-sensitive prostate cancer with rising PSA after local therapy: EMBARK study design." BMJ Open 11, no. 8 (2021): e046588. http://dx.doi.org/10.1136/bmjopen-2020-046588.

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IntroductionLimited data from controlled clinical trials are available for men who experience biochemical recurrence after definitive therapy for prostate cancer. In the absence of overt metastases, patients with non-metastatic castration-sensitive prostate cancer (nmCSPC) often receive androgen deprivation therapy (ADT). There is no standard-of-care consensus on optimal ADT timing, although most men are treated prior to metastases, especially those with high-risk features (Gleason score 8–10 or prostate-specific antigen doubling time (PSADT) <9–12 months). Given data that ADT plus novel ho

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Gerhard, Rene, and Scott L. Boerner. "Evaluation of Indeterminate Thyroid Cytology by Second-Opinion Diagnosis or Repeat Fine-Needle Aspiration: Which Is the Best Approach?" Acta Cytologica 59, no. 1 (2015): 43–50. http://dx.doi.org/10.1159/000369332.

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Objective: This study investigated a published series evaluating the role of second-opinion diagnosis (SOD) or repeat fine-needle aspiration cytology (RFNA) for indeterminate thyroid aspirates. Study Design: Twenty-three studies were selected and the following parameters were analyzed: disagreement between SOD or RFNA and the original diagnosis (OD), reclassification of OD according to the Bethesda system for reporting thyroid cytopathology, the rate of definitive diagnosis and the diagnostic performance of SOD and RFNA. Results: 7,154 thyroid FNAs were retrieved from 9 studies that investigat

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Parkhouse, Bonnie L. "Sport Management Curricula: Current Status and Design Implications for Future Development." Journal of Sport Management 1, no. 2 (1987): 93–115. http://dx.doi.org/10.1123/jsm.1.2.93.

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The current status of undergraduate and graduate curricula in sport management was examined in 83 institutions identified as offering sport management programs in the United States (40 undergraduate, 32 graduate, and 11 programs at both levels). Since only two Canadian institutions responded to this inquiry, definitive conclusions could not be drawn about the current status of sport management in Canada. However, several observations about them are made on the basis of external data. The findings of this study clearly indicate that sport management curricula varies markedly from one institutio

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Pepas, Litha P., Alexandra Savis, Annette Jones, Gurleen K. Sharland, Robert M. R. Tulloh, and John M. Simpson. "An echocardiographic study of tetralogy of Fallot in the fetus and infant." Cardiology in the Young 13, no. 3 (2003): 240–47. http://dx.doi.org/10.1017/s1047951103000477.

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Objective: To document the echocardiographic features of tetralogy of Fallot during fetal and postnatal life. Correlation of echocardiographic findings with the requirement for early intervention prior to definitive repair. Design: Retrospective observational study. Setting: A tertiary fetal cardiology unit. Patients: Fetuses with a diagnosis of tetralogy of Fallot identified from a prospective database between 1 January 1999 and 31 October 2002. Main measures of outcome: Growth of aorta and pulmonary trunk during fetal and postnatal life. Doppler assessment of the great arteries both prenatal

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Bhargava, Ramya, Philip A. Kalra, Paul Brenchley, Helen Hurst, and Alastair Hutchison. "A Study to Inform the Design of a National Multicentre Randomised Controlled Trial to Evaluate If Reducing Serum Phosphate to Normal Levels Improves Clinical Outcomes including Mortality, Cardiovascular Events, Bone Pain, or Fracture in Patients on Dialysis." International Journal of Nephrology 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/579434.

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Background. Retrospective, observational studies link high phosphate with mortality in dialysis patients. This generates research hypotheses but does not establish “cause-and-effect.” A large randomised controlled trial (RCT) of about 3000 patients randomised 50 : 50 to lower or higher phosphate ranges is required to answer the key question: does reducing phosphate levels improve clinical outcomes? Whether such a trial is technically possible is unknown; therefore, a study is necessary to inform the design and conduct of a future, definitive trial.Methodology. Dual centre prospective parallel

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Luzanin, Ognjan, Vera Guduric, Ivan Ristic, and Simon Muhic. "Investigating impact of five build parameters on the maximum flexural force in FDM specimens – a definitive screening design approach." Rapid Prototyping Journal 23, no. 6 (2017): 1088–98. http://dx.doi.org/10.1108/rpj-09-2015-0116.

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Purpose The purpose of this study was to examine the impact of five key build parameters – layer thickness, deposition angle, infill, extrusion speed and extrusion temperature, and their interactions – on the maximum flexural force in specimens which are made of polylactic acid (PLA). Design/methodology/approach Through a previous study on the flexural properties of PLA specimens, a statistically significant effect of layer thickness was indicated, requiring further experimentation to establish the values of quadratic term in the model, as well as to perform optimization. Instead of performing

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Al-Tamimi, Abdulsalam A., Adi Pandžić, and Edin Kadrić. "Investigation and Prediction of Tensile, Flexural, and Compressive Properties of Tough PLA Material Using Definitive Screening Design." Polymers 15, no. 20 (2023): 4169. http://dx.doi.org/10.3390/polym15204169.

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The material extrusion fused deposition modeling (FDM) technique has become a widely used technique that enables the production of complex parts for various applications. To overcome limitations of PLA material such as low impact toughness, commercially available materials such as UltiMaker Tough PLA were produced to improve the parent PLA material that can be widely applied in many engineering applications. In this study, 3D-printed parts (test specimens) considering six different printing parameters (i.e., layer height, wall thickness, infill density, build plate temperature, printing speed,

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Mohamed, Omar Ahmed, Syed Hasan Masood, and Jahar Lal Bhowmik. "Influence of processing parameters on creep and recovery behavior of FDM manufactured part using definitive screening design and ANN." Rapid Prototyping Journal 23, no. 6 (2017): 998–1010. http://dx.doi.org/10.1108/rpj-12-2015-0198.

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Purpose The purpose of this paper is to investigate the effect of process parameters of fused deposition modelling (FDM) 3D printing process on viscoelastic responses (creep compliance and recoverable compliance) of FDM built parts using a novel experimental design technique. Design/methodology/approach As part of the process characterization, a recently developed class of three-level design methodology – definitive screening design (DSD) – was used in this study to fit a second-order polynomial regression model. Artificial neural network (ANN) was also used to determine the optimal process pa

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Kaja Kamal, Raja Mohammed, Ken Farrington, David Wellsted, et al. "Impact of incremental versus conventional initiation of haemodialysis on residual kidney function: study protocol for a multicentre feasibility randomised controlled trial." BMJ Open 10, no. 8 (2020): e035919. http://dx.doi.org/10.1136/bmjopen-2019-035919.

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IntroductionPreserving residual kidney function (RKF) may be beneficial to patients on haemodialysis (HD) and it has been proposed that commencing dialysis incrementally rather than three times a week may preserve RKF. In Incremental HD, target dose includes a contribution from RKF, which is added to HD dose, allowing individualisation of the HD prescription. We will conduct a feasibility randomised controlled trial (RCT) comparing incremental HD and conventional three times weekly treatments in incident HD patients. The study is designed also to provide pilot data to allow determination of ef

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Melanson, Stacy. "Clinical Benefits of Direct-to-Definitive Testing for Monitoring Compliance in Pain Management." January 2018 1, no. 21;1 (2018): E583—E592. http://dx.doi.org/10.36076/ppj.2018.6.e583.

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Background: The technical advantages of direct-to-definitive liquid chromatographytandem mass spectrometry (LC-MS/MS) urine testing for monitoring patient compliance in pain management are well known. However, the design and implementation of LC-MS/MS methods are more controversial, including factors such as determining appropriate cutoffs, specimen processing (e.g., specimen hydrolysis), reporting of qualitative and/or quantitative results, and test menu. Objectives: The objective of the research was to compare the clinical performance of our previous urine pain toxicology panel, a combinatio

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Griffiths, Robert, Warren Mansell, Timothy A. Carey, Dawn Edge, Richard Emsley, and Sara J. Tai. "Method of levels therapy for first-episode psychosis: rationale, design and baseline data for the feasibility randomised controlled Next Level study." BJPsych Open 4, no. 5 (2018): 339–45. http://dx.doi.org/10.1192/bjo.2018.44.

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BackgroundMethod of levels (MOL) is an innovative transdiagnostic cognitive therapy with potential advantages over existing psychological treatments for psychosis.AimsThe Next Level study is a feasibility randomised controlled trial (RCT) of MOL for people experiencing first-episode psychosis. It aims to determine the suitability of MOL for further testing in a definitive trial (trial registration ISRCTN13359355).MethodThe study uses a parallel group non-masked feasibilityRCT design with two conditions: (a) treatment as usual (TAU) and (b) TAU plus MOL. Participants (n = 36) were recruited fro

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Abas, Muhammad, Mohammed Alkahtani, Qazi Salman Khalid, Ghulam Hussain, Mustufa Haider Abidi, and Johannes Buhl. "Parametric Study and Optimization of End-Milling Operation of AISI 1522H Steel Using Definitive Screening Design and Multi-Criteria Decision-Making Approach." Materials 15, no. 12 (2022): 4086. http://dx.doi.org/10.3390/ma15124086.

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End-milling operation of steel grade material is a challenging task as it is hard-to-cut material. Proper selection of cutting tools, cutting conditions, and cutting process parameters is important to improve productivity, surface quality, and tool life. Therefore, the present study investigated the end-milling operation of AISI 1522H steel grade under minimum-quantity lubrication (MQL) conditions using a novel blend of vegetable oils, namely canola and olive oil. Cutting process parameters considered were spindle speed (s), feed rate (f), depth of cut (d), width of cut (w), and cutting condit

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