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Dissertations / Theses on the topic 'Drug disease'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Durrant, Jacob Devin. "Computational drug design applied to neglected disease." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3404614.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed June 7, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (leaves 213-239).

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2

Lickteig, Andrew Joseph. "Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193836.

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Correct dosing in pharmacotherapeutics is based on the idea that too much of a drug will cause toxicity, while too little will result in failure to elicit the desired response. A major factor in the ability of a patient to handle any dose of a drug is the capacity to metabolize and eliminate that drug from the body. For the vast majority of drugs, the liver plays a key role in determining the rate at which drugs are eliminated. First, drugs must be taken up across the cell membrane into hepatocytes by uptake transporters. Once inside the hepatocyte, biotransformation enzymes metabolize and con

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3

Grosset, Katherine Anne. "Therapy concordance and drug adherence in Parkinson's disease." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/2341/.

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Chapter 1 gives an overview of the relevance of studying therapy adherence in Parkinson’s disease. Chapter 2 examines drug induced neurological syndromes and considers the validity of patients’ concerns about taking prescribed medications. Chapter 3 compares different methods of assessing therapy adherence. Chapter 4 studies factors associated with sub-optimal medicine usage in 54 patients. Chapter 5 reports a study of patient perceived involvement with management decisions and an assessment of satisfaction with the movement disorder service in 107 patients. Chapter 6 explores patients’ belief

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4

Sappy, Immaculate. "Ribonucleic Acids in Disease Etiology and Drug Discovery." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1566562465233197.

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5

TONON, FEDERICA. "Exploring drug molecular effects in cancer disease models." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908483.

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. As usually HCC diagnosis occurs in the advanced stage of the disease, available treatments such as resection, liver transplant, or local ablation are poorly if not at all effective. Also systemic chemotherapy has limited effectiveness. The only drug that can prolong patient survival is Sorafenib; unfortunately, however, the extent of increased survival is very modest being of few months. Together the above considerations clearly indicate that the development of novel therapeutic approaches for HCC are

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6

Shams, Tahiatul. "Solute Carrier Transporters in drug-drug/herb interactions and their molecular regulation in disease." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20342.

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Solute Carrier Transporters (SLCs) are a group of influx transporters responsible for the cellular uptake of endogenous substances and exogenous molecules including a number of clinically important drugs. They are widely expressed in epithelium throughout the body, where they play essential roles in determining the disposition and elimination of these substances. They have been recognized as the crucial determinants to drug pharmacokinetics in humans. The dysfunction of SLC transporters contributes to the pathophysiology of several diseases, as well as largely impacts on drug pharmacokinetic p

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7

Freeman, J. G. "Therapeutic modalities in liver disease." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378854.

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8

Ibrahim, N. "Drug-related problems (DRPs) in children with kidney disease." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1448344/.

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Introduction: Medicines are used with the intention of benefitting from their effect. The effects of medicines can also be undesirable and potentially lead to harm. A drug-related problem (DRP) is a term used to describe problem(s) that exist in the use of medicines. There remains a distinct paucity of data on the epidemiology of DRPs in children with kidney disease. Aim: To investigate the epidemiology of DRPs in children with kidney disease in clinical practice at tertiary Paediatric Nephrology units. Methods: Study 1: Prospective observational study on the characteristics of DRPs in hospita

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9

Terrasso, Ana Paula Barreto. "Neural cell models for disease modeling and drug discovery." Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2018. http://hdl.handle.net/10362/98065.

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"Neurological disorders are a major public health problem and are expected to rise dramatically together with the higher life expectancy and the shift towards an ageing society. Current therapeutic options can only ameliorate some of the symptoms and there are no effective treatments to target pathological mechanisms and stop disease progression. The human brain complexity hampers the understanding of the brain functioning at the molecular, cellular, and pathophysiological levels for many neurological disorders. This highlights the need for new brain models, which can contribute to unveil mole

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10

Nyren-Erickson, Erin Kathryn. "In Vitro Detection of Disease Biomarkers and Drug Contaminants." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27018.

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In recent years the rising cost and increased regulation within the U.S. healthcare system have caused medical laboratory tests to become more costly and more frequently required. As a result, insurance premiums are rising, and small independent laboratories are threatened with closure as their already narrow margins dwindle. Concurrently, there have been several incidents of contaminants and impurities in pharmaceutical drugs causing hundreds of deaths and thousands of illnesses. These challenges substantiate the need for simple and cost-effective screening tests for the presence of disease b

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11

Yaddanapudi, Suryanarayana. "Machine Learning Based Drug-Disease Relationship Prediction and Characterization." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1565349706029458.

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12

Chau, Ying. "Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32332.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references.<br>We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic clearance, thereby improving the pharmacokinetics of the attached drugs. Traditionally, linkers are degraded by acidity or by some ubiquitous intracellular enzyme

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13

Gopalakrishnan, Sathej [Verfasser], and Wilhelm [Akademischer Betreuer] Huisinga. "Mathematical modelling of host-disease-drug interactions in HIV disease / Sathej Gopalakrishnan ; Betreuer: Wilhelm Huisinga." Potsdam : Universität Potsdam, 2016. http://d-nb.info/1218401133/34.

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14

Barua, Neil U. "Convection-enhanced drug delivery and its application to Alzheimer's disease." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617593.

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15

Ho, Yuen-shan, and 何宛珊. "Investigation of lycium barbarum as neuroprotective drug against Alzheimer's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572388.

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16

Wu, Calvin. "In Vitro Cortical Networks for Disease Modeling and Drug Evaluation." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407860/.

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In translational research, disease models in preclinical studies are used as media for discovery of drugs or novel therapeutics. Development of in vitro models for various neurological diseases that enable efficient pharmacological or toxicological screening has been ongoing but challenging. Recognizing the potential benefit of in vitro disease models, dysfunctions in the cortical neuronal networks were induced to mimic the functional pathology of neurological symptoms using microelectrode arrays. Two different disease states – tinnitusand excitotoxicity – were investigated and discussed. In t

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17

Samtani, Grace, and Grace Samtani. "Evaluation of Drug "X" in Preclinical Models of Parkinson's Disease." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625144.

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Parkinson's disease (PD) is a hypokinetic, age-related movement disorder associated with chronic, progressive degeneration of dopaminergic neurons, with cell bodies located in the substantia nigra pars compacta (SNpc) and axon terminals in the striatum. Striatal depletion of the neurotransmitter dopamine (DA) gives rise to the cardinal PD motor symptoms. We utilized a 6-hydroxydopamine (6-OHDA) animal PD model to test the application of a preclinical drug candidate, drug "X", in ameliorating and/or preventing advanced parkinsonism in two studies. First, a neurorestoration study tested th

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18

Ho, Yuen-shan. "Investigation of lycium barbarum as neuroprotective drug against Alzheimer's disease." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43572388.

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19

Davani, Lara <1992&gt. "Development of advanced analytical methodologies for Alzheimer’s disease drug discovery." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10295/1/Ph.D.%20Thesis%20Lara%20Davani%20caricamento.pdf.

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Advanced analytical methodologies were developed to characterize new potential active MTDLs on isolated targets involved in the first stages of Alzheimer’s disease (AD). In addition, the methods investigated drug-protein bindings and evaluated protein-protein interactions involved in the neurodegeneration. A high-throughput luminescent assay allowed the study of the first in class GSK-3β/ HDAC dual inhibitors towards the enzyme GSK-3β. The method was able to identify an innovative disease-modifying agent with an activity in the micromolar range both on GSK-3β, HDAC1 and HDAC6. Then, the same a

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20

Watchon, Maxinne. "Investigating disease mechanisms and potential drug treatments in a transgenic zebrafish model of Machado-Joseph disease." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20272.

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Machado-Joseph disease (MJD) is a neurodegenerative disease resulting in the loss of muscle control and coordination. This disease is caused by inheritance of the ATXN3 gene containing an expanded CAG trinucleotide repeat region encoding for the polyglutamine (polyQ) tract in the ataxin-3 protein. Normally, the length of the CAG repeat region is between 12-44 repeats whilst MJD patients harbour >44 repeats. There is no known treatment or cure to prevent disease progression and understanding the mechanisms causing MJD neuropathology are limited. Thus, there are various cell and animal models ex

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21

Smith, Breland Elise. "Small Molecule Approaches Toward Therapeutics for Alzheimer's Disease and Colon Cancer." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337213.

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The research described in this dissertation is focused on the knowledge-based, often in silico assisted design, targeted synthesis, and biological evaluation of small molecules of interest for two translational medicinal chemistry projects. The first project (Part 1) is aimed at the identification of blood brain barrier (BBB) penetrable dual specificity tyrosine phosphorylation regulated kinase-1A (DYRK1A) inhibitors as a potential disease modifying approach to mitigate cognitive deficits associated with Alzheimer's neurodegeneration. Two major series with potent activity against DYRK1A were i

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22

Pérez, Areales Francisco Javier. "Novel multi-target directed ligands as drug candidates against Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404781.

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Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, current treatments are only symptomatic, but do not prevent, halt, or delay the disease progression. In the light of the multiple mechanisms involved in its pathogenesis, such as dysfunction of cholinergic and glutamatergic neurotransmitter systems, amyloid and tau pathologies, or oxidative stress, among others, the traditional medicinal chemistry approach of developing drugs b

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23

Pont, Masanet Caterina. "Multitarget strategies in search of novel drug candidates against Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668672.

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Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current commercialised treatments are only symptomatic, but are not capable of preventing, curing or even delaying the disease progression. Because AD arises from a complex network of pathological events, such as dysfunction in neurotransmitter systems (mainly cholinergic and glutamatergic), β-amyloid and tau proteins disorders, oxidative stress or neuroinflammation, amongst others, the

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24

Lewandowski, Eric Michael. "Structure Based Drug Design Targeting Bacterial Antibiotic Resistance and Alzheimer's Disease." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5982.

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Structure based drug design is a rapidly advancing discipline that examines how protein targets structurally interact with small molecules, or known inhibitors, and then uses this information to lead inhibitor optimization efforts. In the case of novel inhibitors, protein structural information is first obtained via X-ray crystallography, NMR studies, or a combination of both approaches. Then, computational molecular docking is often used to screen, in silico, millions of small molecules and calculate the potential interactions they may have with the target protein’s binding pocket, in hopes o

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25

Yang, Sen. "Disease, Drug, and Target Association Predictions by Integrating Multiple Heterogeneous Sources." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1342194249.

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26

Hernández, Teruel Adrián. "Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/129863.

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[ES] La presente tesis doctoral titulada "Sistemas de liberacio'n controlada de fa'rmacos diseñados para mejorar el tratamiento de Enfermedad Inflamatoria Intestinal" se centra en el diseño, preparación, caracterización y evaluación in vivo de distintos sistemas de liberación controlada de fármacos en colon (CDDS, por sus siglas en inglés) utilizando como soporte micropartículas de silice mesoporosa, funcionalizadas con puertas moleculares. En conclusión, los estudios realizados demuestran que los materiales de silice mesoporosa, en combinación con puertas moleculares sensibles a estímulos es

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27

Alghamdi, Shareefa. "Consequences of non-alcoholic fatty liver disease on drug-induced hepatocytoxicity." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/808210/.

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Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid in liver. Liver is the principal organ involved in drug biotransformation. The central hypothesis of this project is that alterations in the liver environment due to lipid accumulation aggravate sensitivity of hepatocytes to toxicity of some commonly prescribed drugs (paracetamol, alcohol, phenobarbital, cisplatin or doxorubicin). The aim of this study was to investigate the effect of lipid overloading (steatosis) on drug cytotoxicity in the liver model Huh7 cell line. Hepatic steatosis was induced in Huh7

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28

Merrell, Matthew David. "Xenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/194051.

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A large and varied array of xenobiotics (foreign chemicals) enters into our bodies every day. In order to prevent toxicity resulting from xenobiotic accumulation, the body has developed a complex and integrated network of enzymes and transporters to promote and control the metabolism and excretion of drugs and other compounds. Drug metabolizing enzymes are classified as oxidative (Phase I) or conjugative (Phase II), and generally result in increased hydrophilicity of their substrates. Drug transporters actively route xenobiotics into (Phase 0) or out of (Phase III) the cells. The expression o

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29

Li, Y. M. J. "An in-vivo study of the anti-arrhythmic and electrophysiological effects of amiodarone, lignocaine and penticainide (CM7857) in the rat." Thesis, De Montfort University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233821.

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30

Crispo, James Alexander George. "Pharmacotherapies in Parkinson Disease: Investigating Trends and Adverse Health Outcomes." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35065.

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Parkinson disease (PD) is the second most common neurodegenerative disease worldwide, with estimates suggesting that PD prevalence and incidence will increase with aging populations. Therapeutic options and clinical guidelines for PD have significantly changed over the past 15 years; however, pharmacoepidemiology data in PD are lacking, especially regarding adverse effects of non-ergot dopamine agonists (DAs) and outcomes associated with anticholinergic burden. The objectives of this doctoral research are threefold: 1) examine patterns of antiparkinson drug use in relation to clinical guidelin

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31

Zent, Clive Steven, and Clive Steven Zent. "The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/24969.

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The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological

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32

Donovan, Mark C. "Taking aim : target populations and the wars on drugs and AIDS /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/10736.

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33

Little, Eden. "Evaluation of bioactive natural products from traditional Chinese medicines against a-synuclein-targeted drug screening." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/398094.

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Parkinson’s Disease belongs to a group of overlapping neurodegenerative disorders called α-Synucleinopathies. Patients are diagnosed by degeneration of dopaminergic neurons and the presence of Lewy bodies within surviving neurons of the Substantia Nigra Pars Compacta. These Lewy bodies are proteinaceous deposits of α-Synuclein. This intrinsically disordered protein pathologically aggregates into toxic oligomers or β-sheet fibril species. Currently there are no known drugs available to treat or reverse the pathogenesis of this disease. Therefore there is an unmet clinical need to find small mol

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34

Liang, Yousheng. "Studies on the resistance of Schistosoma to Praziquantel, an anti-schistosomal drug." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368563.

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35

Kumari, Vandana. "Structure-Based Computer Aided Drug Design and Analysis for Different Disease Targets." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311612599.

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36

Jokinen, Mika. "Effects of drug interactions and liver disease on the pharmacokinetics of ropivacaine." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/jokinen/.

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37

Winter, Helen Rayma. "Strategies to reduce arylamine drug toxicity in people with AIDS /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/7937.

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38

Soozandehfar, Seyed Hashem. "A study of azo reduction as an approach to colon-specific drug delivery." Thesis, University of Brighton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309181.

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39

SONI, SISWANTO. "A drug repurposing study based on clinical big data for the treatment of interstitial lung disease." Kyoto University, 2020. http://hdl.handle.net/2433/259020.

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40

Sola, Lao Irene. "Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399594.

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This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel anti-malarial target. The work carried out in the frame of this PhD Thesis has followed three research lines, thus dividing the next report on three main objectives, namely the development of novel diseasemodifying anti‐Alzheimer agents, novel potential 4-aminoquinoline-based anti tripanosomatid compounds, and so far unexplored substrate analog PfG6PD inhibitors for the trea

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41

Mitrev, Nikola. "Therapeutic drug monitoring guided anti-tumour necrosis factor therapy in inflammatory bowel disease (IBD): Gastroenterological Society of Australia (GESA)/ Australian IBD Association (AIBDA) consensus statements." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17449.

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INTRODUCTION: Growing evidence supports the use of therapeutic drug monitoring (TDM) to guide anti-tumour necrosis factor (TNF) drug treatment among patients with inflammatory bowel disease (IBD). Currently, TDM for anti-TNF drugs is variably practiced by gastroenterologists in Australia. Our aim was to develop consensus statements for TDM of anti-TNF drugs in IBD that will be endorsed by the Australian IBD Association (AIBDA) of the Gastroenterological Society of Australia (GESA). METHODS: A consensus committee of 25 Australian and international experts was assembled. A systematic literature

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42

Hutchinson, Sharon J. "Modelling the hepatitis C virus disease burden among injecting drug users in Scotland." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/1340/.

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A forward projection model was used to estimate the numbers of, both current and former, IDUs who acquired HCV infection and progressed to mild, moderate and severe HCV disease in Glasgow and Scotland between 1960 and 2030. The model was developed initially for Glasgow because more epidemiological information exists for this region, than elsewhere in Scotland, to calibrate model outcomes with local data relating to HCV and its consequence. Insights gained from the model fitting process in Glasgow were then used to extend the model to the rest of Scotland. First, the incidence and cessation of

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Stevens, J. C. "The use of a health status indicator to evaluate disease and drug therapy." Thesis, Cardiff University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375605.

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Flinders, Bryn. "The use of MALDI-MS for imaging drug disposition in respiratory disease models." Thesis, Sheffield Hallam University, 2013. http://shura.shu.ac.uk/19652/.

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Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) has been extensively applied to monitoring the distribution of pharmaceutical compounds in tissues. The main aim of the work reported in this thesis is to monitor the distribution of respiratory compounds in the lungs following inhaled delivery. Glucocorticoids that contain multiple carbonyl functionalities are not easily protonated/de-protonated to form charged species due to the poor ionisation efficiencies of the carbonyl functionalities. Derivatisation with hydrazine based reagents has been proposed as a solu

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Lee, K. V. "Optimisation and analysis of sustained release drug delivery systems to treat ocular disease." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400532/.

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Transscleral drug delivery has been a moreviable alternative drug delivery route to the posterior segment than other more invasive methods. The drug absorption involves passing through several layers of tissue, including the sclera and retinal pigment epithelium (RPE), to reach the retina. Posterior scleral thickness in both humans and normal C57BL/6 mice decreases with age. Lipofuscin density in albino mice’s eyes were two-fold higher than in pigmented mice and the drug-binding to these pigments could affect drug bioavailability. Drug molecular weight didn’t correlate with penetration efficie

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46

Heikkinen, Helena. "Entacapone, a drug for Parkinson's disease : a pharmacokinetic and pharmacodynamic study of entacapone." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/heikkinen/.

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47

Cross, Megan. "Structure-based drug discovery using trehalose-6-phosphate phosphatase, an infectious disease target." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/384294.

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Over 400 million people are currently affected by parasitic worm infections. While seldom fatal, the long-term consequences of helminthiases are significant and global burden is estimated at 22 million disability adjusted life years per annum. Amid growing concerns of zoonosis, treatment resistance and geographical expansion, there has been a call for the development of novel anti-parasitic strategies. To minimise potential treatment side effects, common approaches target proteins that are essential for parasite survival but absent from the host genome. One such target is the essential enzyme

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48

Fisher, Craig. "Non-Alcoholic Fatty Liver Disease Alters the Three Stages of Hepatic Drug Management." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195795.

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In pharmacotherapeutics, the term "correct dosing" is based on the concept that too high a systemic concentration will lead to drug toxicity, while drug levels that are too low may not produce the intended therapeutic effect. Often, the factors determining the ability of a patient to manage a given dose rely on their capacity to efficiently metabolize and eliminate drugs from the body. The liver plays a crucial role in the processing of many clinically relevant drugs via three stages of hepatic drug management. Drugs must first be taken into hepatocytes by uptake transporters. Drugs are th

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Brizi, Valerio. "Engineering complex kidney structures for disease modelling, drug testing, and studying kidney development." Thesis, Open University, 2018. http://oro.open.ac.uk/53445/.

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Although existing kidney tissue engineering systems and cell-based strategies favoured significant advances in the field, they cannot reproduce the organ’s complex architecture. This prevented the use of these tissues in studying kidney development realistically, modelling diseases, and establishing therapeutic approaches. To fill these gaps, we devised a 3D engineering system for rapid generation of custom-made geometrically predefined kidney units that more faithfully resemble their counterparts <i>in vivo</i>. Combining 3D printing and PDMS prototyping, we fabricated differently sized and s

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Di, Martino Rita Maria Concetta <1987&gt. "Naturally Inspired Privileged Structures in Drug Discovery: Multifunctional Compounds for Alzheimer's Disease Treatment." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7582/1/DiMartino_RitaMariaConcetta_tesi.pdf.

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Polypharmacology-based strategies are gaining ever-increasing attention as useful approaches to develop disease-modifying drug candidates for effective Alzheimer’s disease (AD) treatment. In this scenario, multitarget-directed ligands could increase efficiency by simultaneous modulation of several targets involved in AD pathogenesis. In drug discovery, natural products (NPs) represent an excellent source of evolutionary-chosen “privileged structures”. In this thesis, the polyphenol curcumin, found in Curcuma longa L, encompassing the essential structural elements for the concurrent inhibition

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