Relevant bibliographies by topics / Free light chains Lambda

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Free light chains Lambda'

Author: Grafiati
Published: 24 April 2022
Last updated: 30 July 2025

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Journal articles on the topic "Free light chains Lambda"

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Cotariu, D., S. Kaufman, A. Golik, S. Scharf, and J. L. Zaidman. "Heavy- and free light-chain myeloma associated with peripheral polyneuropathy." Clinical Chemistry 34, no. 12 (1988): 2594–95. http://dx.doi.org/10.1093/clinchem/34.12.2594.

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Abstract Peripheral polyneuropathy, a rare complication of multiple myeloma, is generally associated with heavy-chain M-proteins and, in very rare instances, with free light-chain myeloma proteins. Here we describe a case of multiple myeloma and polyneuropathy with both monoclonal IgG and free lambda light chains in the blood. The patient also had free lambda light chains in the cerebrospinal fluid and urine.
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Ambrosino, D. M., M. V. Kanchana, N. R. Delaney, and R. W. Finberg. "Human B cells secrete predominantly lambda L chains in the absence of H chain expression." Journal of Immunology 146, no. 2 (1991): 599–602. http://dx.doi.org/10.4049/jimmunol.146.2.599.

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Abstract Ig H and L chains are independently assembled in B cells and then secreted together as a functional protein. H chains cannot be secreted without assembly to L chains; however, L chains can be secreted in the absence of H chains by both mice and human cells. To examine the influence of H chain expression on human L chain isotype selection (kappa or lambda), we compared the kappa/lambda ratio of L chains unassociated with H chains (free L chains) to the kappa/lambda ratio of L chains associated with H chains. Culture supernatants of human splenocytes were assayed for kappa and lambda L
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Wrightham, M., AL Tutt, MJ Glennie, TJ Hamblin, GT Stevenson, and FK Stevenson. "Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes." Blood 69, no. 3 (1987): 919–23. http://dx.doi.org/10.1182/blood.v69.3.919.919.

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Abstract Tumor cells from patients with B cell neoplasms often secrete small amounts of free monoclonal light chains that can be found in the urine. Such tumor-derived light chains of the lambda type from a patient with typical chronic lymphocytic leukemia have been used to raise mouse monoclonal antibodies (MoAbs). A hybridoma-secreting antibody that recognized the idiotypic lambda chain but not normal lambda chains by a preliminary screen but which also reacted with idiotypic IgM from the patient's tumor cells was selected. This MoAb in fact recognized 1 in 20 X 10(3) molecules of pooled nor
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Wrightham, M., AL Tutt, MJ Glennie, TJ Hamblin, GT Stevenson, and FK Stevenson. "Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes." Blood 69, no. 3 (1987): 919–23. http://dx.doi.org/10.1182/blood.v69.3.919.bloodjournal693919.

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Tumor cells from patients with B cell neoplasms often secrete small amounts of free monoclonal light chains that can be found in the urine. Such tumor-derived light chains of the lambda type from a patient with typical chronic lymphocytic leukemia have been used to raise mouse monoclonal antibodies (MoAbs). A hybridoma-secreting antibody that recognized the idiotypic lambda chain but not normal lambda chains by a preliminary screen but which also reacted with idiotypic IgM from the patient's tumor cells was selected. This MoAb in fact recognized 1 in 20 X 10(3) molecules of pooled normal lambd
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Lee, Won S., and Gurmukh Singh. "Serum Free Light Chain Assay in Monoclonal Gammopathic Manifestations." Laboratory Medicine 50, no. 4 (2019): 381–89. http://dx.doi.org/10.1093/labmed/lmz007.

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Abstract Background Serum free light chain assay is used in the diagnosis and monitoring of monoclonal gammopathic manifestations. For the kappa (κ)/lambda (λ) ratio, there is a 36% false-positive rate in patients without monoclonal gammopathic manifestations and a 30% false-negative rate in patients with monoclonal gammopathic manifestations. This study was undertaken to address the higher false-negative rate in λ chain–associated monoclonal lesions. Methods Results of serum protein electrophoresis, serum immunofixation electrophoresis, and serum free light chain assays were reviewed retrospe
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Šegulja, Dragana, Danica Matišić, Karmela Barišić, and Dunja Rogić. "Verification study of free light chains assays on reagent-optimized analysers." Biochemia medica 29, no. 3 (2019): 579–86. http://dx.doi.org/10.11613/bm.2019.030709.

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Introduction: Our aim was to compare analytical specifications of two assays (monoclonal vs. polyclonal) for free light chains (FLCs) quantification optimized for two different analytical platforms, nephelometer ProSpec (Siemens, Erlangen, Germany) and turbidimetric analyser Optilite (The Binding Site, Birmingham, UK). Materials and methods: The evaluation included verification of the precision, repeatability and reproducibility, estimation of accuracy and method comparison study with 37 serum samples of haematological patients. Kappa and lambda FLC were measured in each sample by both methods
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Treger, Rebecca, Kathleen Hutchinson, Andrew Bryan, and Chihiro Morishima. "Lambda monoclonal free light chain abnormalities detected by a serum immunofixation electrophoresis assay are underrepresented by quantitative serum free light chain results." American Journal of Clinical Pathology 156, Supplement_1 (2021): S13—S14. http://dx.doi.org/10.1093/ajcp/aqab189.023.

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Abstract Protein and immunofixation (IFIX) electrophoresis are used to diagnose and monitor monoclonal gammopathies. While IFIX detects clonal production of intact immunoglobulins and free light chains (FLC), the latter can also be quantified using a serum free light chain (SFLC) assay, in which polyclonal antisera detects epitopes specific for free kappa (KFLC) or lambda light chains (LFLC). An abnormal KFLC: LFLC ratio (KLR) serves as a surrogate for clonality. While the SFLC assay is highly sensitive, normal LFLC (<2.63mg/dL) and KLR results (>0.26 & <1.65) were fou
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Arneth, Borros, and Jörg Kraus. "The Use of Kappa Free Light Chains to Diagnose Multiple Sclerosis." Medicina 58, no. 11 (2022): 1512. http://dx.doi.org/10.3390/medicina58111512.

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Background: The positive implications of using free light chains in diagnosing multiple sclerosis have increasingly gained considerable interest in medical research and the scientific community. It is often presumed that free light chains, particularly kappa and lambda free light chains, are of practical use and are associated with a higher probability of obtaining positive results compared to oligoclonal bands. The primary purpose of the current paper was to conduct a systematic review to assess the up-to-date methods for diagnosing multiple sclerosis using kappa and lambda free light chains.
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Levinson, Stanley S. "kappa/lambda index for confirming urinary free light chain in amyloidosis AL and other plasma cell dyscrasias." Clinical Chemistry 37, no. 6 (1991): 1122–26. http://dx.doi.org/10.1093/clinchem/37.6.1122.

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Abstract Primary systemic amyloidosis (AL), a disease involving the deposition of immunoglobulin light chains in tissue, is caused by a plasma cell dyscrasia. In the case of amyloidosis reported here, no monoclonal component was seen upon routine protein electrophoresis of serum or urine nor was a bone marrow analysis positive for AL. Immunofixation electrophoresis did not show a typical paraprotein band but did show, in the gamma region, two large diffuse bands and a lower concentration of oligoclonal-type bands, all of which stained for free lambda but not for free kappa chain. The ratio of
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Dul, J. L., S. Aviel, J. Melnick, and Y. Argon. "Ig light chains are secreted predominantly as monomers." Journal of Immunology 157, no. 7 (1996): 2969–75. http://dx.doi.org/10.4049/jimmunol.157.7.2969.

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Abstract Ig light (L) chains are secreted not only as part of assembled Ab molecules, but also as free L chains, the latter process being involved in the pathology of several diseases. The secretion competence of free L chains distinguishes them from free subunits of other oligomeric proteins, which are usually retained intracellularly. We used several techniques to test the idea that secretion of free L chains is dependent on dimerization. Coexpression of pairs of L chains, differing in only one amino acid, which alters the secretory phenotype, shows that these L chains behave independently:
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Dissertations / Theses on the topic "Free light chains Lambda"

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Basnayake, Kolitha Indika. "The biology of immunoglobulin free light chains in kidney disease : a study of Monoclonal and Polyclonal light chains." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/2862/.

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Monoclonal immunoglobulin free light chains (FLCs) cause a range of disorders in the kidney. In multiple myeloma, FLCs can activate the proximal tubule to release MCP-1, an important cytokine in renal fibrosis. Distal tubular cast formation can also occur when FLCs co-precipitate with uromodulin. However a pathogenic role for the elevated polyclonal FLC concentrations seen in chronic kidney disease has not been assessed to date. This thesis explores the biology of monoclonal FLCs as well as polyclonal FLCs. Detailed histological analyses demonstrated that in multiple myeloma, interstitial fibr
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Vecchio, Domizia. "Kappa free light chains as a biomarker in multiple sclerosis." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/128428.

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Introduction. Mulple Sclerosis (MS) cerebrospinal fluid (CSF) hallmarks are increased intrathecal immunoglobulins (Ig) and free light chains of kappa subtype (KFLC). Aims . To evaluate KFLC towards MS diagnosis and prognosis. Methods. We enrolled subjects who underwent CSF study in their diagnosc work up at the Novara University Hospital. KFLC were measured in CSF and serum by nephelometry to calculate kappa index:(CSF KFLC/serum KFLC)/(CSF albumin/serum albumin). Results. First, CSF KFLC were significantly higher in MS versus not-MS, and we defined a cut-off of 5 for kappa index in a
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Rimsza, Lisa, William Day, Sarah McGinn, et al. "Kappa and lambda light chain mRNA in situ hybridization compared to flow cytometry and immunohistochemistry in B cell lymphomas." BioMed Central, 2014. http://hdl.handle.net/10150/610134.

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BACKGROUND:Detection of B cell clonality is useful for assisting in the diagnosis of B cell lymphomas. Clonality assessment can be accomplished through evaluation of KAPPA and LAMBDA light chain expression. Currently, only slide based methods are available for the majority of patient biopsies and do not detect light chain protein or mRNA in many B-cell lymphomas. Herein we evaluated a new method, known as colorimetric in situ hybridization (CISH), with improved sensitivity and multiplexing capacity, for its usefulness in clonality detection in mature B cell malignancies.METHODS:The KAPPA and L
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Levraut, Michaël. "Évaluations des chaînes légères libres sériques et intrathécales comme biomarqueur diagnostique et pronostique dans la sclérose en plaques." Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ6055.

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La sclérose en plaques (SEP) est la maladie inflammatoire du système nerveux central (SNC) la plus fréquente et est la première cause de handicap d'origine non traumatique dans les populations d'adultes jeunes. Le pronostic neurologique des patients atteints de SEP s'est amélioré ces 20 dernières années grâce à l'avènement des thérapeutiques immuno-actives et les révisions successives des critères diagnostiques, se voulant de plus en plus sensibles. Cependant, ce gain de sensibilité entraîne une diminution de spécificité, avec un risque d'erreurs diagnostiques plus fréquentes. Nous manquons do
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Germishuys, Jurie J. "Free light chains in patients with HIV: establishing local reference ranges and their association with stage of disease, chronic antigen stimulation and the effect of Haart." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20173.

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Thesis (MMedSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Background: Serum free light chains (FLC) are associated with imbalances in heavy and light chain production. Abnormal FLC ratios have been associated with risk of progression in certain diseases. Automated assays are available for their determination and they are used in the followup and management of patients with monoclonal gammopathies. Acceptable imprecision, specificity, accuracy and reproducibility between reagent batches is required to prevent under- or overestimation. Method validation is a standard process in
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Frölich, Britta. "Bedeutung freier Leichtketten im Urin bei Patienten mit chronisch entzündlicher rheumatischer Erkrankung." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E429-9.

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Books on the topic "Free light chains Lambda"

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Kuypers, Dirk R. J., and Morie A. Gertz. Light-chain deposition disease. Edited by Giuseppe Remuzzi. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0154_update_001.

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Light-chain deposition disease (LCDD) is characterized by extracellular tissue deposition of non-amyloid monoclonal immunoglobulin light chains (predominantly kappa light chains) in various organs including kidneys, heart, and liver. It is a rare cause of renal insufficiency. In two-thirds of cases it is associated with multiple myeloma, while in the remainder their monoclonal B cell proliferation does not meet the criteria for that diagnosis.Renal involvement occurs almost invariably and dominates the clinical course of the disease: greater than 90% of patients with LCDD have renal functional
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Eastmead, Stephen P. Enzyme immunoassay of human free immunoglobin light chains. 1985.

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Gallaher, Katie, and José de la Cruz. Butterflies Set Free: Breaking the Chains of 21st-Century Slavery by Bringing It into the Light. Independently Published, 2022.

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Kastritis, Efstathios, and Meletios A. Dimopoulos. The patient with myeloma. Edited by Giuseppe Remuzzi. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0153_update_001.

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Renal impairment is a common feature of multiple myeloma and often the presenting symptom of a patient with symptomatic myeloma. ‘Myeloma kidney’ results from the excess of immunoglobulin light chains which form aggregates and casts that result in tubular obstruction; however, light chains may cause renal damage with a variety of mechanisms, which often may coexist in the same patient. The presence of significant renal dysfunction in a patient with myeloma is associated with a risk for significant complications, including early death. Myeloma kidney is usually associated with high tumour burde
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Book chapters on the topic "Free light chains Lambda"

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Cohen, Gerald, and Walter H. Hörl. "Free Immunoglobulin Light Chains." In Uremic Toxins. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118424032.ch18.

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Fouquet, Guillemette, Stéphanie Poulain, Suzanna Schraen, et al. "Laboratory Investigations and Findings: Hematological Abnormalities, Biochemical Investigations, Free Light and Heavy Chains." In Waldenström’s Macroglobulinemia. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22584-5_17.

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Sindic, C. J. M. "The detection of IgA, IgM and free light chains abnormalities in cerebrospinal fluid." In Cerebrospinal Fluid Analysis in Multiple Sclerosis. Springer Milan, 1996. http://dx.doi.org/10.1007/978-88-470-2205-8_4.

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Mayo, Mary M., and Gretchen Schaef Johns. "Serum Free Light Chains in the Diagnosis and Monitoring of Patients with Plasma Cell Dyscrasias." In Contributions to Nephrology. KARGER, 2006. http://dx.doi.org/10.1159/000096760.

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Paternoster, Gianluca, Paolo Fabbrini, and Imma Attolico. "Extracorporeal Removal of Serum-Free Light Chains in Patients with Multiple Myeloma-Associated Acute Kidney Injury." In Reducing Mortality in Acute Kidney Injury. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33429-5_17.

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Rudick, Richard A. "Free Light Chains of Immunoglobulins in Multiple Sclerosis: A Putative Index of the Intrathecal Humoral Immune Response." In Cellular and Humoral Immunological Components of Cerebrospinal Fluid in Multiple Sclerosis. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4899-5348-3_23.

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Hegen, Harald, and Florian Deisenhammer. "Oligoclonal Bands: Isoelectric Focusing and Immunoblotting, and Determination of κ Free Light Chains in the Cerebrospinal Fluid." In Neuromethods. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1319-1_3.

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van Steijn, J., J. Bijzet, H. de Wit, et al. "Serum Levels of Free Kappa and Lambda Light Chains in Patients with Systemic AL, AA, and ATTR Amyloidosis." In Amyloid and Amyloidosis. CRC Press, 2004. http://dx.doi.org/10.1201/9781420037494-37.

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Hazenberg, B. P. C., J. Bijzet, H. de Wit, J. van Steijn, E. Vellenga, and M. H. van Rijswijk. "Diagnostic Value of Free Kappa and Lambda Light Chains in Fat Tissue of Patients with Systemic AL Amyloidosis." In Amyloid and Amyloidosis. CRC Press, 2004. http://dx.doi.org/10.1201/9781420037494-38.

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van de Belt, K., H. de Wit, B. Hazenberg, et al. "Serum Levels of Free Kappa and Lambda Light Chains in Patients with Systemic Al, Aa, and Attr Amyloidosis." In Amyloid and Amyloidosis. CRC Press, 2004. http://dx.doi.org/10.1201/9781420037494.ch35.

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Conference papers on the topic "Free light chains Lambda"

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Loureiro, G., LSA Rocha, DD Pereira, et al. "IMPORTÂNCIA DA QUANTIFICAÇÃO DAS CADEIAS LEVES KAPPA E LAMBDA LIVRES URINÁRIAS NO ESTUDO DAS PARAPROTEÍNAS." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.7189.

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Objetivo: Avaliar a sensibilidade e a especificidade da dosagem das CLLs por imunoturbidimetria com relação à eletroforese e à imunofixação de proteínas urinárias. Método: Trinta e oito amostras de urina da rotina laboratorial (isolada e de 24 horas) foram avaliadas. Os exames de eletroforese e imunofixação das proteínas urinárias foram solicitados. A detecção das CLLs por eletroforese e imunofixação foi realizada no equipamento SPIFE II (Helena, USA). A dosagem quantitativa das CLL foi realizada por método imunoturbidimétrico, utilizando um conjunto diagnóstico da marca Freelite (Binding Site
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Chailyan, Anna, Davide Cirillo, Paolo Marcatili, and Anna Tramontano. "Structural landscape of immunoglobulin lambda light chains." In the First ACM International Conference. ACM Press, 2010. http://dx.doi.org/10.1145/1854776.1854901.

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Tent, Michiel. "Cerebrospinal fluid kappa-free light chains for MS diagnosis." In ECTRIMS Congress 2022, edited by Hans-Peter Hartung. Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/5ddc21fc.

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Rodriguez Cambron, A. B., J. Jimenez Jimenez, M. A. Blazquez Cañamero, et al. "FRI0344 Serum free light chains as a flare biomarker in systemic lupus erythematosus." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.5374.

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Belghali, S., S. Lataoui, S. Ferchichi, et al. "FRI0165 Serum free light chains of immunoglobulins in rheumatoid arthritis: correlation with interstitial lung disease." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.6364.

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Amin, S., E. J. Atkinson, S. J. Achenbach, A. Dispenzieri, R. A. Kyle, and S. V. Rajkumar. "THU0470 Non-clonal elevation of serum immunoglobulin free light chains is predictive of hip fracture in both women and men." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6041.

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Hu, Wei, Ola Landgren, Bryan Bassig, et al. "Abstract 5074: Elevated serum free light chains and risk of non-Hodgkin lymphoma and the subtype follicular lymphoma in a prospective cohort study." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5074.

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Esteban, Jorge Illarramendi, Ivan Quispe, Mercedes Rodriguez, et al. "BREAST PLASMACYTOMA: A CASE TREATED WITH IRRADIATION THAT EVOLVED TO FURTHER BILATERAL BREAST INVOLVEMENT AND SYSTEMIC DISEASE REFRACTORY TO CHEMOTHERAPY." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2078.

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Introduction: Plasmacytomas are uncommon malignant lesions in the breast. Further knowledge is needed about the presentation, diagnosis, and therapy of this disease. Case report: A 78-year-old woman had a previous diagnosis of sacral bone plasmacytoma in March 2005 that was treated with radiotherapy. A new lesion involved in the cervical spine in 2008 was also irradiated. A mammogram and ultrasound found two well-defined nodules in January 2012 in the upper outer quadrant of the right breast, with a total diameter of 38 mm. Biopsy showed a proliferation of cells with Ki-67 staining in more tha
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Ishiguro, H., S. Higashiyama, C. Namikawa, I. Ohkubo, and M. Sasaki. "MAPPING OF FUNCTIONAL DOMAINS OF HUMAN HIGH MOLECULAR WEIGHT (HMW) AND LOW MOLECULAR WEIGHT (LMW) KININOGENS BY USING MURINE MONOCLONAL ANTIBODIES (MAbs)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642849.

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It has been widely known that HMW and LMW kininogens are the large potential sources of kinin in human blood, and that HMW kininogen also functions as a cofactor in the contact activation of blood coagulation. Recently, it has been demonstrated that the heavy chains of kininogens strongly inhibited a number of cysteine proteinases such as calpains, cathepsins, papain and ficin. We made an attempt at mapping of functional domains on the molecules of both kininogens by using MAbs.Thirty four MAbs raised against human HMW and LMW kininogens were screened by ELISA. By using HMW kininogen, kinin-fr
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LOFTUS, J. C., E. F. Plow, A. L. Frelinger III, M. A. Smith, S. D’ouza, and M. H. Ginsberg. "LOCALIZATION AND CHEMICAL SYNTHESIS OF A DIVALENT CATION REGULATED EPITOPE IN PLATELET MEMBRANE GPIIb." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643959.

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Platelet membrane glycoprotein (GP)IIb-IIIa is a component of a common adhesive protein receptor for fibrinogen, fibronectin, and von Willebrand factor. A monoclonal antibody, PMI-1, defines a divalent cation dependent regulation of the surface orientation of the heavy chain of GPIIb. Exposure of the PMI-1 epitope inversely correlates with the capacity of platelets to bind fibrinogen and aggregate. We have now localized and chemically synthesized this epitope. A 1.1 Kb cDNA clone which directs the synthesis of a fusion protein which bears the PMI-1 epitope was isolated from a lambda gt 11 expr
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