Relevant bibliographies by topics / HDMO

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'HDMO'

Author: Grafiati
Published: 11 September 2021
Last updated: 15 February 2022

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Journal articles on the topic "HDMO"

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Medina-Medina, Ixaura, Paola García-Beltrán, Ignacio de la Mora-de la Mora, Jesús Oria-Hernández, Guy Millot, Robin Fahraeus, Horacio Reyes-Vivas, José G. Sampedro, and Vanesa Olivares-Illana. "Allosteric Interactions byp53mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions." Molecular and Cellular Biology 36, no. 16 (May 23, 2016): 2195–205. http://dx.doi.org/10.1128/mcb.00113-16.

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HDM2 and HDMX are key negative regulatory factors of the p53 tumor suppressor under normal conditions by promoting its degradation or preventing itstransactivity, respectively. It has more recently been shown that both proteins can also act as positive regulators of p53 after DNA damage. This involves phosphorylation by ATM on serine residues HDM2(S395) and HDMX(S403), promoting their respective interaction with thep53mRNA. However, the underlying molecular mechanisms of how these phosphorylation events switch HDM2 and HDMX from negative to positive regulators of p53 is not known. Our results show that these phosphorylation events reside within intrinsically disordered domains and change the conformation of the proteins. The modifications promote the exposition of N-terminal interfaces that support the formation of a new HDMX-HDM2 heterodimer independent of the C-terminal RING-RING interaction. The E3 ubiquitin ligase activity of this complex toward p53 is prevented by thep53mRNA ligand but, interestingly, does not affect the capacity to ubiquitinate HDMX and HDM2. These results show how ATM-mediated modifications of HDMX and HDM2 switch HDM2 E3 ubiquitin ligase activity away from p53 but toward HDMX and itself and illustrate how the substrate specificity of HDM2 E3 ligase activity is regulated.
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Bernal, Federico, Mark Wade, Amy M. Silverstein, Gregory L. Verdine, Geoffrey M. Wahl, and Loren D. Walensky. "A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer." Blood 112, no. 11 (November 16, 2008): 2645. http://dx.doi.org/10.1182/blood.v112.11.2645.2645.

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Abstract p53 is a transcription factor that induces cell cycle arrest or apoptosis in response to DNA damage and cellular stress, and thereby plays a critical role in protecting cells from malignant transformation. The E3 ubiquitin ligase HDM2 controls p53 levels through a direct binding interaction that neutralizes the transactivation activity of p53 and targets it for degradation via the ubiquitylation-proteasomal pathway. Whereas the HDM2-homologue HDMX lacks ubiquitin ligase function, it participates in regulating the p53 axis by heterodimerizing with HDM2 and sequestering p53 through protein interaction. Loss of p53 activity, either by deletion, mutation, or HDM2/HDMX overexpression, is the most common defect in human cancer. Tumors expressing wild type p53 are rendered vulnerable by pharmacologic approaches that stabilize and upregulate p53. In this context, HDM2 and HDMX have emerged as independent therapeutic targets for restoring p53 activity and resensitizing cancer cells to apoptosis in vitro and in vivo. The small molecule nutlin-3 is an effective antagonist of the p53-HDM2 interaction. However, several studies have demonstrated the inability of nutlin-3 to disrupt the p53-HDMX complex, rendering tumor cells that overexpress HDMX nutlin-3-resistant. We have previously described the synthesis and characterization of a hydrocarbon-stapled alpha-helical p53 peptide (SAH-p53-8) that binds HDM2 with low nanomolar affinity, targets HDM2 in situ, and reactivates the p53 tumor suppressor pathway in HDM2-overexpressing osteosarcoma cells. We now report that SAH-p53-8 binds HDMX with even higher affinity, co-immunoprecipitates with endogenous HDMX, and induces apoptosis and cell cycle arrest in nutlin-3-resistant cancer cells that overexpress HDMX. Thus, by inserting a chemical staple into a peptide fragment of the p53 transactivation domain, we have generated the first bifunctional inhibitor of HDM2 and HDMX, enabling the investigation and pharmacologic modulation of both targets in human cancer.
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Pereg, Yaron, Suzanne Lam, Amina Teunisse, Sharon Biton, Erik Meulmeester, Leonid Mittelman, Giacomo Buscemi, et al. "Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage." Molecular and Cellular Biology 26, no. 18 (September 15, 2006): 6819–31. http://dx.doi.org/10.1128/mcb.00562-06.

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ABSTRACT The p53 tumor suppressor plays a major role in maintaining genomic stability. Its activation and stabilization in response to double strand breaks (DSBs) in DNA are regulated primarily by the ATM protein kinase. ATM mediates several posttranslational modifications on p53 itself, as well as phosphorylation of p53's essential inhibitors, Hdm2 and Hdmx. Recently we showed that ATM- and Hdm2-dependent ubiquitination and subsequent degradation of Hdmx following DSB induction are mediated by phosphorylation of Hdmx on S403, S367, and S342, with S403 being targeted directly by ATM. Here we show that S367 phosphorylation is mediated by the Chk2 protein kinase, a downstream kinase of ATM. This phosphorylation, which is important for subsequent Hdmx ubiquitination and degradation, creates a binding site for 14-3-3 proteins which controls nuclear accumulation of Hdmx following DSBs. Phosphorylation of S342 also contributed to optimal 14-3-3 interaction and nuclear accumulation of Hdmx, but phosphorylation of S403 did not. Our data indicate that binding of a 14-3-3 dimer and subsequent nuclear accumulation are essential steps toward degradation of p53's inhibitor, Hdmx, in response to DNA damage. These results demonstrate a sophisticated control by ATM of a target protein, Hdmx, which itself is one of several ATM targets in the ATM-p53 axis of the DNA damage response.
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Juckett, Lisa. "MENTAL HEALTH AND HUNGER: RISK FACTORS FOR HOSPITALIZATION AMONG HOME-DELIVERED MEAL PARTICIPANTS." Innovation in Aging 3, Supplement_1 (November 2019): S227. http://dx.doi.org/10.1093/geroni/igz038.837.

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Abstract Home-delivered meals (HDMs) provided through the Older Americans Act (OAA) are intended to reduce hunger, promote socialization, and maximize wellness. However, HDM recipients are at increased likelihood of being hospitalized due to their complex health needs and risk for social isolation and depression. Drawing data from the OAA-HDM National Survey, we evaluated the predictors of hospitalization among HDM recipients in 2017. From our sample (n = 578), we conducted random forest classification analyses to identify the most important risk factors related to HDM recipient hospitalization. Our random forest model yielded an accuracy rate of 66.3% with risk factors most indicative of hospitalization being attributed to number of co-morbidities, depressive symptoms, and feelings of social isolation. These findings indicate that although HDMs may help alleviate hunger among older adults, innovate strategies are warranted to address the unmet mental health needs of HDM recipients.
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Linares, L. K., A. Hengstermann, A. Ciechanover, S. Muller, and M. Scheffner. "HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53." Proceedings of the National Academy of Sciences 100, no. 21 (September 24, 2003): 12009–14. http://dx.doi.org/10.1073/pnas.2030930100.

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Harker, Elizabeth A., Douglas S. Daniels, Danielle A. Guarracino, and Alanna Schepartz. "β-Peptides with improved affinity for hDM2 and hDMX." Bioorganic & Medicinal Chemistry 17, no. 5 (March 2009): 2038–46. http://dx.doi.org/10.1016/j.bmc.2009.01.039.

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Beekman, Andrew M., Marco M. D. Cominetti, Samuel J. Walpole, Saurabh Prabhu, Maria A. O'Connell, Jesus Angulo, and Mark Searcey. "Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design." Chemical Science 10, no. 16 (2019): 4502–8. http://dx.doi.org/10.1039/c9sc00059c.

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Carvajal, Luis, Daniela Ben-Neriah, Adrien Senecal, Lumie Benard, Swathi-Rao Narayanagari, Charles Kenworhty, Victor Thiruthuvanathan, et al. "Dual inhibition of HDMX and HDM2 in acute myeloid leukemia." Experimental Hematology 53 (September 2017): S46. http://dx.doi.org/10.1016/j.exphem.2017.06.058.

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Hayashi, Ryo, Deyun Wang, Toshiaki Hara, Jaclyn A. Iera, Stewart R. Durell, and Daniel H. Appella. "N-Acylpolyamine inhibitors of HDM2 and HDMX binding to p53." Bioorganic & Medicinal Chemistry 17, no. 23 (December 2009): 7884–93. http://dx.doi.org/10.1016/j.bmc.2009.10.032.

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Yasuda, Yuichiro, Tatsuya Nagano, Kazuyuki Kobayashi, and Yoshihiro Nishimura. "Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model." Cells 9, no. 5 (May 9, 2020): 1178. http://dx.doi.org/10.3390/cells9051178.

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Asthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among innate immune cells, group 2 innate lymphoid cells (ILC2s) have been considered to be crucial for eosinophilic airway inflammation by releasing T helper 2 cytokines. Moreover, house dust mites (HDMs) belonging to group 1 act on airway epithelial cells not only as allergens but also as cysteine proteases. The production of interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP) from airway epithelial cells was induced by the protease activity of HDMs. These cytokines activate ILC2s, and activated ILC2s produce IL-5, IL-9, IL-13, and amphiregulin. Hence, the HDM-induced asthma mouse model greatly contributes to understanding asthma pathogenesis. In this review, we highlight the relationship between ILC2s and the HDM in the asthma mouse model to help researchers and clinicians not only choose a proper asthma mouse model but also to understand the molecular mechanisms underlying HDM-induced asthma.
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Dissertations / Theses on the topic "HDMO"

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Rojas, Fernandez Alejandro [Verfasser]. "Regulation of Hdm2, HdmX-mediated ubiquitination and neddylation / Alejandro Rojas Fernandez." Konstanz : Bibliothek der Universität Konstanz, 2010. http://d-nb.info/1024034968/34.

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Mpagi, Meldrick Daniel. "In Search For New p53 Regulated Genes." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1227282714.

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Heminger, Katherine Ann. "LOSS OF HDMX LEADS TO ALTERATIONS IN GENE EXPRESSION AND INHIBITION OF CELL GROWTH IN TUMOR CELLS WITH WILD-TYPE p53." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1175282827.

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Jani, Meghna. "Transcriptional regulation of LAMB3 by p53." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1229958362.

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Nystøyl, Bjarte Løken. "HDMI Transmitter." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for elektronikk og telekommunikasjon, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-18483.

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HDMI is the de facto global standard for connecting HD components and bridging the gap between consumer electronics and personal computer products, making it a priority to develop efficient hand-held, battery-powered units that support the standard.This is a study into how to design a low power and high performance system that can transmit HDMI-signals to a valid HDMI-receiver. The main priority is to implement the TMDS part of a HDMI-transmitter, where parallel data is encoded and serialized at high frequencies. The theory chapters provides an orderly summary of the complex workings of the HDMI-standard, in addition to an introduction to high-performance digital circuit design. This is followed by a system specification chapter, which sets the constraints of the design and discusses the hardware requirements. The subsequent chapter first deals with the design of a straightforward, basic HDMI-transmitter, before moving on to an enhanced design process. The basic design is used as a base for discussions in regard to how effective the suggested enhancement techniques are. The improvements result in an enhanced design able to operate at 742,5 MHz and support High-Definition video at the impressive resolution of 1080p30. This is achieved by using a 180nm, low-leakage library, and the final design consists of approximately 24.000 unit-sized transistor equivalents, consuming approximately a total of 13,6 mW.
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Gu, Xun. "HDMI frame grabber." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1526915.

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The High-Definition Multimedia Interface (HDMI) is widely adopted by the modern media devices, and supporting HDMI source is required in many streaming and broadcasting solutions. This paper introduces an HDMI frame grabber design which will capture the image from an HDMI source, and then display the image on both a local HDMI display and a remote computer screen. As a result, the captured frame will be shared in the different locations across the network. The project design involves the embedded hardware/software development on a Xilinx FPGA board, and GUI/Network programming on the Microsoft .NET framework. The paper describes the embedded design to enable the HDMI and Ethernet peripherals on the FPGA board, analyzes the data format and protocol difference among the network nodes, and then introduces the method to convert and transport the data.

Keywords: Embedded Design, FPGA, HDMI, lwIP, Network Programming.

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Yu, Grace Wang. "Characterization of HDM2 domains." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613861.

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Čurda, Pavel. "Měřicí přístroj HDO signálů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-400610.

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The thesis deals with the introduction of the measuring instrument SVA - M on the market for compliance with electromagnetic compatibility and electrical safety requirements. Furthermore it deals with determination of measuring accuracy instrument SVA - M and measurement uncertainties. For the determination of accuracy there is a theoretical analysis and subsequent practical measurements.
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Bartek, Tomáš. "Řídící obvod s rozhraním HDMI pro modulární LED displeje." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-242003.

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This work deals with modernization of information LED panels. It mainly focuses on utilizing input HDMI interface into FPGA, which controls modular LED displays, but also on ensuring professional functions such as communication with control unit, thermal security and detection of faulty LED.
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Kaltea, Eddie, and Daniel Lundgren. "Utveckling och konstruktion av analysatorverktyg för styrsignaler i HDMI-gränssnittet." Thesis, Linköping University, Linköping University, Computer Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16789.

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Utveckling av produkter som skall stöda HDMI-standarden medför många hinder som behöver överkommas. Ett av problemen är certifiering mot standarden. Det är svårt att testa att standardens alla krav uppfylls på ett utvecklingsföretag då testutrustningen är kostsam och därför ej tillgänglig. Ett enkelt verktyg har därför utvecklats för att underlätta testning av att standarden följs.

Denna rapport inleds med en problemställning och grundläggande teori om relaterade ämnen. En förstudie följer sedan där olika sätt att lösa problemet presenteras. Sedan följer en övergripande beskrivning om hur verktyget fungerar och hur det tillverkades. I slutet på rapporten finns en efterstudie och resultat som beskriver hur verktygets utveckling har fungerat och hur resultatet från förstudien påverkat utvecklingen.

Resultatet av examensarbetet är en prototyp som går att använda för att underlätta testning av att HDMI-standarden följs i vissa avseenden.

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Books on the topic "HDMO"

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Söhn, Gerhart. Handbuch der Original-Graphik in deutschen Zeitschriften, Mappenwerken, Kunstbüchern und Katalogen (HDO), 1890-1933. Düsseldorf: Edition GS, 1989.

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Watanatada, Thawat. Description of the HDM-III Model (World Bank). The Johns Hopkins University Press, 1988.

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Watanatada, Thawat. Users Manual for the HDM-Model (World Bank). The Johns Hopkins University Press, 1988.

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1974-, Li Jianhua, Washington (State). Dept. of Transportation. Research Office., United States. Federal Highway Administration., and Washington State Transportation Center, eds. Application of HDM-4 in the WSDOT highway system. [Olympia, Wash.]: Washington State Dept. of Transportation, 2004.

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Archondo-Callao, Rodrigo. HDM-PC (The Highway design and maintenance standards series). World Bank, 1988.

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Vernon and Soud. Fgd Installations on Coal Fired Plants (Order #iea.Cr-90.08.Hdm). Natl Technical Information, 1990.

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Transporte, Instituto Mexicano del, ed. Aplicación del HDM-III a la red carretera federal del Estado de Puebla. Sanfandila, Qro: Instituto Mexicano del Transporte, Secretaria de Comunicaciones y Transportes, 2001.

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Sohn, Gerhart. Handbuch Der Original-Graphik in Deutschen Zeitschriften,Mappenwerken,Kunsbuchern Und Katalogen (Hdo 1890-1933). Alan Wofsy Fine Arts, 1990.

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White and Maibodi. Assessment of Control Technologies for Reducing Emissions of S02 and Nox from Existing Coal-Fired Utility Boilers (Order # Pb90-2735-74/Hdm). Natl Technical Information, 1990.

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Banco de Proyectos de Inversión Nacional (Colombia), Colombia. Departamento Nacional de Planeación. Unidad de Inversiones y Finanzas Públicas. Division de Metodologías., and Latin American and Caribbean Institute for Economic and Social Planning. Project and Advisory Assistance Programme., eds. Manual para la evaluación de proyectos de vias nacionales y regionales mediante el uso del programa HDM: The highway design and maintenance standard model : documento preparado para el Banco de Proyectos de Inversión Nacional de Colombia por el Convenio DNP-BID-ILPES (ATN/JF-3342-CO). [Colombia]: República de Colombia, Departamento Nacional de Planeación, Unidad de Inversiones y Finanzas Públicas, División de Metodologías, División de Operación y Sistemas, 1992.

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Book chapters on the topic "HDMO"

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Gay, Warren. "LCD HDMI Display." In Advanced Raspberry Pi, 451–64. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3948-3_24.

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Doyle, D. John. "Hemodynamic Monitoring (HDM) Program." In Computer Programs in Clinical and Laboratory Medicine, 29–38. New York, NY: Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4612-3576-7_6.

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Venuti, Steve, Jim Chase, and Laurie Iwami. "High-Definition Multimedia Interface (HDMI®)." In Handbook of Visual Display Technology, 1–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-35947-7_37-2.

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Tobias, Rob, Jim Chase, Jeff Park, and Bramy Brad. "High-Definition Multimedia Interface (HDMI®)." In Handbook of Visual Display Technology, 1–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-642-35947-7_37-3.

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Chase, Jim. "High Definition Multimedia Interface (HDMI®)." In Handbook of Visual Display Technology, 481–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-79567-4_37.

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Shereena, O. A., and B. Nageswara Rao. "HDMR-Based Bayesian Structural System Identification." In Lecture Notes in Civil Engineering, 453–64. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0362-3_36.

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Tobias, Rob, Jim Chase, Jeff Park, and Brad Bramy. "High Definition Multimedia Interface (HDMI®)." In Handbook of Visual Display Technology, 695–709. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-14346-0_37.

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Gazi, Orhan, and A. Çağrı Arlı. "Video Graphic Array (VGA) and HDMI Interfacing." In State Machines using VHDL, 237–307. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-61698-4_6.

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Keesara, Yashwant Reddy, Rashi Vatsa, and Someet Singh. "4K HDMI USB3 capture card reference design." In Intelligent Circuits and Systems, 517–24. London: CRC Press, 2021. http://dx.doi.org/10.1201/9781003129103-79.

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De Carvalho, J. P. M., and P. P. Avelino. "Cosmic Strings With Self-Interacting Hdm." In The Non-Sleeping Universe, 323–24. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4497-1_80.

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Conference papers on the topic "HDMO"

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Park, Bu S., Joshua W. Guag, Leonardo M. Angelone, and Sunder S. Rajan. "A Novel Method to Decrease Electric Field and SAR Using an External High Dielectric Sleeve at 3T Head MRI: Numerical and Experimental Results." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16133.

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We present experimental and numerical simulation results showing that high dielectric materials (HDMs) located outside of a RF head coil decrease the electric field (E-field, |E|) with minimum change of the RF magnetic field (B1+) at 3T MRI imaging. Compared to previous research using HDMs located between the RF coil and sample, our method locating the HDM outside the coil allowed an increased sample size and more flexibility of HDM thickness optimization. Numerical simulation results showed more than 30% decrease in the local SAR at the boundary region of the head model. Validating experimental results showed a 21% decrease in the maximum |Etotal| using a HDM made of distilled water.
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Camarero, Julio A. "Abstract A134: Therapeutic targeting of Hdm2/HdmX E3 ligase with bioactive cyclotides." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-a134.

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Park, Bu S., Sunder S. Rajan, and Leonardo M. Angelone. "A New Method to Concentrate Electromagnetic Field Within ROI Using a High Dielectric Material in 3T Body MRI." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16135.

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We present numerical simulation results showing that high dielectric materials (HDMs) when placed between the human body model and the body coil significantly alter the electromagnetic field inside the body. The numerical simulation results show that the electromagnetic field (E, B, and SAR) within a region of interest (ROI) is concentrated (increased). In addition, the average electromagnetic fields decreased significantly outside the region of interest. The calculation results using a human body model and HDM of Barium Strontium Titanate (BST) show that the mean local SAR was decreased by about 56% (i.e., 18.7 vs. 8.2 W/kg) within the body model.
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Singh, Harman, Neeti Dhanak, Haroon Ansari, and Krishan Kumar. "HDML." In the 7th International Conference. New York, New York, USA: ACM Press, 2017. http://dx.doi.org/10.1145/3154979.3154996.

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Bernal, Federico, Mark Wade, Geoffrey M. Wahl, and Loren D. Walensky. "Abstract C174: Therapeutic reactivation of p53 through dual targeting of HDM2 and HDMX with a stapled p53 peptide." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c174.

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Rondon, Luis Puche, Leonardo Babun, Kemal Akkaya, and A. Selcuk Uluagac. "HDMI-walk." In ACSAC '19: 2019 Annual Computer Security Applications Conference. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3359789.3359841.

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Hajikolaei, Kambiz Haji, and G. Gary Wang. "A Global High Dimensional Metamodeling Approach With the Ability of Using Non-Uniform Sampling." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-35316.

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In engineering design, spending excessive amount of time on physical experiments or expensive simulations makes the design costly and lengthy. This issue exacerbates when the design problem has a large number of inputs, or of high dimension. High Dimensional Model Representation (HDMR) is one powerful method in approximating high dimensional, expensive, black-box (HEB) problems. One existing HDMR implementation, Random Sampling HDMR (RS-HDMR), can build a HDMR model from random sample points with a linear combination of basis functions. The most critical issue in RS-HDMR is that calculating the coefficients for the basis functions includes integrals that are approximated by Monte Carlo summations, which are error prone with limited samples and especially with non-uniform sampling. In this paper, a new approach based on Principal Component Analysis (PCA), called PCA-HDMR, is proposed for finding the coefficients that provide the best linear combination of the bases with minimum error and without using any integral. Benchmark problems are modeled using the method and the results are compared with RS-HDMR results. With both uniform and non-uniform sampling, PCA-HDMR built more accurate models than RS-HDMR for a given set of sample points.
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8

Rao, B. N., and Rajib Chowdhury. "Structural Reliability Evaluation Using Enhanced HDMR." In ASME 2008 Pressure Vessels and Piping Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/pvp2008-61876.

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This paper presents a new computational tool for predicting failure probability of randomly parametered structural/mechanical systems based on high dimensional model representation (HDMR) generated from low order function components. HDMR is a general set of quantitative model assessment and analysis tools for capturing the high-dimensional relationships between sets of input and output model variables. When first-order HDMR approximation of the original high dimensional implicit limit state/performance function is not adequate to provide desired accuracy to the predicted failure probability, this paper presents an enhanced HDMR (eHDMR) method to represent the higher order terms of HDMR expansion by expressions similar to the lower order ones with monomial multipliers. The accuracy of the HDMR expansion can be significantly improved using preconditioning with a minimal number of additional input-output samples without directly invoking the determination of second- and higher order HDMR terms. This study aims to assess how accurately and efficiently eHDMR approximation technique can capture complex model output uncertainty. As a part of this effort, the efficacy of HDMR approximation, which is recently applied to reliability analysis, is also demonstrated. Once the approximate form of implicit response function is defined using HDMR/eHDMR, the failure probability can be obtained by statistical simulation.
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Haji Hajikolaei, Kambiz, and G. Gary Wang. "Adaptive Orthonormal Basis Functions for High Dimensional Metamodeling With Existing Sample Points." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70480.

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High Dimensional Model Representation (HDMR) is a tool for generating an approximation of an input-output model for a multivariate function. It can be used to model a black-box function for metamodel-based optimization. Recently the authors’ team has developed a radial basis function based HDMR (RBF-HDMR) model that can efficiently model a high dimensional black-box function and, moreover, to uncover inner variable structures of the black-box function. This approach, however, requests a complete new, although optimized, set of sample points, as dictated by the methodology, while in engineering design practice one often has many existing sample data. How to utilize the existing data to efficiently construct a HDMR model is the focus of this paper. We first identify the Random-Sampling HDMR (RS-HDMR), which uses orthonormal basis functions as HDMR component functions and existing sample points can be used to calculate the coefficients of the basis functions. One of the important issues related to the RS-HDMR is that in theory the basis functions are obtained based on the continuous integrations related to the orthonormality conditions. In practice, however, the integrations are approximated by Monte Carlo summation and thus the basis functions may not satisfy the orthonormality conditions. In this paper, we propose new and adaptive orthonormal basis functions with respect to a given set of sample points for RS-HDMR approximation. RS-HDMR models are built for different test functions using the standard and new adaptive basis functions for different number of sample points. The relative errors for both models are calculated and compared. The results show that the models that are built using the new basis functions are more accurate.
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Du, Yang, Tingting Liu, Yiping Dai, Gang Fan, Jiangfeng Wang, and Pan Zhao. "Performance Prediction of a Multi-Stage Ammonia-Water Turbine Under Variable Nozzle Operation via Machine Learning." In ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/gt2021-59615.

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Abstract This study proposes machine learning models to predict the performance of a multi-stage ammonia-water radial turbine using variable nozzle operation under different operating conditions. A 1.2 MW four-stage ammonia-water radial turbine is firstly designed. Then, the one-dimensional off-design simulation model is developed based on the geometric parameters to mainly evaluate the effects of different nozzle outlet angles and turbine inlet temperatures on the turbine performance. A set of data, which consists of 10,000 training points based on one-dimensional model, is used to train the proposed two high-dimensional model representation (HDMR) methods. The forward HDMR model predicts the mass flow rate, turbine outlet temperature, turbine power and turbine efficiency for any combination of turbine nozzle outlet angle and turbine inlet temperature, while the reverse HDMR model predicts the mass flow rate, turbine outlet temperature, turbine efficiency and turbine nozzle outlet angle for any combination of turbine power and turbine inlet temperature. The two HDMR models are validated using 238 sets of separated test data. The results show that the minimum coefficients of determination (R2) of forward HDMR model and reverse HDMR model are 0.9837 and 0.9953, respectively. The maximum relative errors of two HDMR models are below 1.6822%, so the quality of the proposed machine learning methods is high. The overall performance maps of multi-stage ammonia-water radial turbine under the variable nozzle operation method are constructed based on the reverse HDMR model. The reverse HDMR model is helpful in monitoring the healthy operation state of turbine.
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Reports on the topic "HDMO"

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Camarero, Julio A., Krishnapa Jagadish, Yanbin Ji, Mark Wade, and Geoffrey Wahl. Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada583420.

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Camerero, Julio A. Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction. Fort Belvoir, VA: Defense Technical Information Center, March 2011. http://dx.doi.org/10.21236/ada545593.

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Camarero, Julio. Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada560756.

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4

Spindler, Martin, Christian Hansen, and Victor Chernozhukov. hdm: High-Dimensional Metrics. The IFS, August 2016. http://dx.doi.org/10.1920/wp.cem.2016.3716.

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Spindler, Martin, Victor Chernozhukov, and Philipp Bach. Valid simultaneous inference in high-dimensional settings (with the HDM package for R). The IFS, June 2019. http://dx.doi.org/10.1920/wp.cem.2019.3019.

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