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Li, Zhe Kun, Min Li, and Fu Yu Li. "Intelligent MES Based on RFID." Key Engineering Materials 407-408 (February 2009): 194–97. http://dx.doi.org/10.4028/www.scientific.net/kem.407-408.194.
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By taking the advantages of RFID (Radio frequency identification) technology, this paper consequently raises an idea of applying RFID into MES (Manufacturing Execution System), establishing the modules concerning MES onsite-material management and monitoring of manufacturing, and studying how to construct Intelligent MES.
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Gao, Wei Zeng, Yue Sheng Gu, and Yan Li Zhu. "Design for Refrigerator Assembly." Advanced Materials Research 538-541 (June 2012): 2932–36. http://dx.doi.org/10.4028/www.scientific.net/amr.538-541.2932.
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In refrigerator industry, takt time becomes shorter with the growth of refrigerator production, product configurations become more diverse with the increase of customizing requirements, traditional data acquisition methods and manufacturing resource identification methods cannot meet the need of manufacturing execution system (MES) in job shop scheduling, work in process (WIP) tracking, rapid response of process control and so on. As an automatic identification technology, Radio Frequency Identification (RFID) can be applied to bridge the gap between physical flow of product/part and information flow in enterprise application system due to its characteristics such as automatic identification, long-distance reading, and non-line-of sight. Based on this characteristic, this paper design a real-time MES (RT-MES) for refrigerator production and successfully implements this system based on the actual situation of JAC.
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Wang, Chuang, Xu’nan Chen, Abdel-Hamid Soliman, and Zhixiang Zhu. "RFID Based Manufacturing Process of Cloud MES." Future Internet 10, no. 11 (October 30, 2018): 104. http://dx.doi.org/10.3390/fi10110104.
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RFID (radio frequency identification) is widely used in the manufacturing processes of enterprises. At the same time, with the advent of the Industry 4.0 era, Manufacturing Execution System (MES) systems began to evolve into cloud MES systems. In this paper, a RFID-based manufacturing process for cloud MES is proposed and a framework manufacturing process fora cloud MES system centered on machine tools is constructed. The process division of the manufacturing process, RFID configuration and cloud processing are analyzed, and other key technologies involved in implementing the framework are briefly discussed. Finally, the effectiveness of a RFID-based manufacturing process of cloud MES is verified by two different types of case analysis namely photovoltaic slice production and garment outsourcing processing.
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Kendsersky, Nathan M., Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Michal Odrobina, Kimberly Stegmaier, and John M. Maris. "Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3889. http://dx.doi.org/10.1158/1538-7445.am2022-3889.
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Abstract Background: Neuroblastoma is an extracranial solid tumor of childhood that arises from the developing sympathetic nervous system. Half of patients with high-risk disease do not survive despite multimodal therapy, and survival after relapse is unlikely. Recent studies have characterized two distinct neuroblastoma cell subtypes: the adrenergic (ADRN) subtype of sympathetic noradrenergic-like identity and the mesenchymal (MES) subtype of neural crest-like identity. ADRN-like cells are more aggressive and proliferative, while the MES-like cells are chemotherapy resistant. Neuroblastoma tumors are heterogenous and comprised of both ADRN and MES cell subtypes, which likely leads to differential responses to therapy. Thus, to eliminate cells that may lead to tumor relapse, it is critical to develop therapies against both neuroblastoma subtypes. Methods: To identify candidate subtype-specific therapeutic targets, we used ssGSEA to classify human neuroblastoma tumors into ADRN- or MES-dominant and performed differential expression. We validated subtype-specific targets in additional datasets and models, including transdifferentiated neuroblastoma cell lines (ADRN-to-MES) after inducible overexpression of the MES transcription factor PRRX1. Results: We show ADRN-specific expression of known preclinical and clinical neuroblastoma targets with limited or no expression in MES-dominant tumors. We propose CD276 (B7-H3) and L1CAM as pan-subtype targets with similar expression in both subtypes and stable expression after ADRN-to-MES transdifferentiation. In MES-specific neuroblastoma patient samples and cell lines, we identify the receptor tyrosine kinase AXL as a candidate MES target. MES neuroblastoma cell lines are more sensitive to small molecule AXL inhibitors (Cabozantinib, NPS-1034, and ONO-7475) compared to ADRN cell lines. We also observe higher expression of PDL1 and immunosuppressive chemokines in MES-dominant tumors and cell lines. Finally, we detect AXL and Gas6 transcripts in tumor-resident macrophages and fibroblasts, which may further promote immune evasion. Conclusion: Here we have identified and prioritized ADRN-specific, MES-specific, and pan-subtype neuroblastoma therapeutic targets and suggest AXL-targeted therapy may eliminate both MES-dominant neuroblastoma cells and immune cell populations that contribute to an immunosuppressive microenvironment. Citation Format: Nathan M. Kendsersky, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Michal Odrobina, Kimberly Stegmaier, John M. Maris. Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3889.
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Li, Xue Jun, Peng Wang, and Xin Huang. "Design of Data Acquisition System in MES Based on RFID." Advanced Materials Research 201-203 (February 2011): 852–56. http://dx.doi.org/10.4028/www.scientific.net/amr.201-203.852.
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Manufacturing execution system is the link in the process of enterprise implementation information integration.The application of Radio Frequency Identification technology is important to implement the data collection function of MES. Speculation against the low efficiency, poor in real time, and low security function for data acquisition in a motor manufacturer, established data acquisition system in MES based on RFID,discussed the data collection process, designed structure of the system in detail，analyzed the function requirements,provide anti-collision algorithm to avoid data collection of the label which may be used in the system implementation,finally discussed the principle of coding.
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Modrak, Vladimir, Pavol Semančo, and Martin Straka. "Applying RFID for Synchronization of Factory Floor Documentation in Robotic Manufacturing Cells." Applied Mechanics and Materials 718 (December 2014): 137–42. http://dx.doi.org/10.4028/www.scientific.net/amm.718.137.
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The goal of this article is to present the conceptual model of RFID technology integration with manufacturing information and control system. Offered ideas are motivated to achieve seamless connection between automatic identification of parts on the shop floor level and CAD/CAM/MES and ERP system. The mentioned connection could be accomplished by use of RFID technology to transfer data from shop floor level into MES environment. Modern CAD/CAM systems such as NX provide wide possibilities for generating electronic reports, such as operation lists, setup instruction, tool report, according to own customization. Therefore, the process of shop floor documentation creation in html format is described in this paper as well.
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Ashraf, Muhammad Aleem, Babar Ali, Judith K. Brown, Imran Shahid, and Naitong Yu. "In Silico Identification of Cassava Genome-Encoded MicroRNAs with Predicted Potential for Targeting the ICMV-Kerala Begomoviral Pathogen of Cassava." Viruses 15, no. 2 (February 9, 2023): 486. http://dx.doi.org/10.3390/v15020486.
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Cassava mosaic disease (CMD) is caused by several divergent species belonging to the genus Begomovirus (Geminiviridae) transmitted by the whitefly Bemisia tabaci cryptic species group. In India and other parts of Asia, the Indian cassava mosaic virus-Kerala (ICMV-Ker) is an emergent begomovirus of cassava causing damage that results in reduced yield loss and tuber quality. Double-stranded RNA-mediated interference (RNAi) is an evolutionary conserved mechanism in eukaryotes and highly effective, innate defense system to inhibit plant viral replication and/or translation. The objective of this study was to identify and characterize cassava genome-encoded microRNAs (mes-miRNA) that are predicted to target ICMV-Ker ssDNA-encoded mRNAs, based on four in silico algorithms: miRanda, RNA22, Tapirhybrid, and psRNA. The goal is to deploy the predicted miRNAs to trigger RNAi and develop cassava plants with resistance to ICMV-Ker. Experimentally validated mature cassava miRNA sequences (n = 175) were downloaded from the miRBase biological database and aligned with the ICMV-Ker genome. The miRNAs were evaluated for base-pairing with the cassava miRNA seed regions and to complementary binding sites within target viral mRNAs. Among the 175 locus-derived mes-miRNAs evaluated, one cassava miRNA homolog, mes-miR1446a, was identified to have a predicted miRNA target binding site, at position 2053 of the ICMV-Ker genome. To predict whether the cassava miRNA might bind predicted ICMV-Ker mRNA target(s) that could disrupt viral infection of cassava plants, a cassava locus-derived miRNA–mRNA regulatory network was constructed using Circos software. The in silico-predicted cassava locus-derived mes-miRNA-mRNA network corroborated interactions between cassava mature miRNAs and the ICMV-Ker genome that warrant in vivo analysis, which could lead to the development of ICMV-Ker resistant cassava plants.
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Boot, R. "Frequent major errors in antimicrobial susceptibility testing of bacterial strains distributed under the Deutsches Krebsforschungszentrum Quality Assurance Program." Laboratory Animals 46, no. 3 (July 2012): 253–57. http://dx.doi.org/10.1258/la.2012.011085.
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The Quality Assurance Program (QAP) of the Deutsches Krebsforschungszentrum (DKFZ) was a proficiency testing system developed to service the laboratory animal discipline. The QAP comprised the distribution of bacterial strains from various species of animals for identification to species level and antibiotic susceptibility testing (AST). Identification capabilities were below acceptable standards. This study evaluated AST results using the DKFZ compilations of test results for all bacterial strains showing the number of participants reporting the strain as resistant (R), sensitive (S) or intermediate susceptible (I) to each antibiotic substance used. Due to lack of information about methods used, it was assumed that what the majority of the participants reported (R or S) was the correct test result and that an opposite result was a major error (ME). MEs occurred in 1375 of 14,258 (9.7%) of test results and ME% ranged from 0% to 23.2% per bacterial group–agent group combination. Considerable variation in MEs was found within groups of bacteria and within groups of agents. In addition to poor performance in proper species classification, the quality of AST in laboratory animal diagnostic laboratories seems far below standards considered acceptable in human diagnostic microbiology.
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Ćwikła, Grzegorz. "Real-Time Monitoring Station for Production Systems." Advanced Materials Research 837 (November 2013): 334–39. http://dx.doi.org/10.4028/www.scientific.net/amr.837.334.
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Real-time monitoring of the flow of materials, semi-completed and completed products during production process is necessary practice for every company because of need for optimal production management. Identification of technological operations, parts, products and persons responsible for any production stage is possible using means of processes control devices and automatic identification systems. Paper describes the in-line monitoring station designed for tests of real-time production monitoring methods. Available sources of information are RFiD, bar codes, and vision system. These data sources are integrated into the in-line production monitoring station. Modular production system model or small production system can be placed under the In-line station as an object of monitoring. Advanced PLC integrates control over subsystems and allows communication between hardware and software components of data acquisition system. Data acquired from the in-line research station is stored in a dedicated database, then processed and analysed using MES (Manufacturing Execution System) software.
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Sharma, Sangeeta, Fauzia Tabassum, Sarbjeet Khurana, and Kaveri Kapoor. "Frontline worker perceptions of medication safety in India." Therapeutic Advances in Drug Safety 7, no. 6 (September 16, 2016): 248–60. http://dx.doi.org/10.1177/2042098616665290.
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Background: To explore interprofessionals’ perceptions about patient safety, particularly medication safety and associated factors and barriers. Methods: A total of 389 respondents were recruited using convenience sample in the cross sectional survey. Results: Medication safety was perceived as somewhat safe (60%). One-third of respondents witnessed 3–4 or more medication errors (MEs) within the past 1 year. Out of that, one quarter were reportedly, sentinel events. More sentinel events were witnessed in public hospitals and solo practice clinics compared with corporate hospitals and nursing homes ( p < 0.02). No difference was observed in the occurrence of sentinel events in accredited and nonaccredited facilities ( p = 0.30). Younger respondents witnessed more MEs, whereas accredited hospitals (mostly corporate hospitals) witnessed significantly fewer MEs and graded overall safety as ‘better’. However, most MEs go unreported particularly in solo practice clinics (88%) followed by nursing homes (67%), public hospitals (54%), and corporate hospitals (42%). Error identification and subsequent disclosure was inhibited by several system factors: fear of punitive action and lack of reporting systems. General surgical (46%), medical (42%), and paediatric units (36%), were the most error-prone places. Documentation diverted all healthcare workers from direct patient care. Many doctors and pharmacists from nursing homes, solo clinics and public hospitals reported working overtime. Staff shortages and poor training were overwhelming concerns to all healthcare workers and in public hospitals. Solo clinics and nursing homes perceived more barriers; lack of reporting systems, standard protocol, and resources for patient safety and unfamiliarity with prescribed medications was their overwhelming concern. Other factors threatening MEs were a lack of team approach and openness in interdisciplinary communications, illegible medical orders, and medicines prescribed by brand names. Conclusions: Immediate interventions to improve medication safety include enforcement of legible/printed medical orders in generic names, workforce development, developing standard protocols, and a corresponding change in organizational culture. Accreditation can serve as a driver for improving patient safety.
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Xie, Hao Fei, Chong Yang Li, Guo Qi Zhang, and De Long Su. "Research and Design on Integrating RFID System in Automotive Manufacture Based on Web Service." Applied Mechanics and Materials 568-570 (June 2014): 1593–96. http://dx.doi.org/10.4028/www.scientific.net/amm.568-570.1593.
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In order to remedy the deficiency of application of bar code that needs artificial intervention in automotive manufacture, we propose a solution to integrate Radio Frequency Identification (RFID) system in the original enterprise information system based on Web service. Distributed real-time data of welding, lacquer covering and assembly workshops in the automotive manufacture are collected, that are used in the enterprise information system to provide more productions information for management. Firstly, the architecture of integrating the RFID system and the Manufacturing Execution System (MES) in automotive manufacture is given, that is focused on the RFID system network, the Middleware and the Application Gateway. Finally, web service implementation is designed to integrate RFID system in enterprise information system.
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Fathy, Ahmed, Hegazy Rezk, Dalia Yousri, Abdullah G. Alharbi, Sulaiman Alshammari, and Yahia B. Hassan. "Maximizing Bio-Hydrogen Production from an Innovative Microbial Electrolysis Cell Using Artificial Intelligence." Sustainability 15, no. 4 (February 17, 2023): 3730. http://dx.doi.org/10.3390/su15043730.
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In this research work, the best operating conditions of microbial electrolysis cells (MECs) were identified using artificial intelligence and modern optimization. MECs are innovative materials that can be used for simultaneous wastewater treatment and bio-hydrogen production. The main objective is the maximization of bio-hydrogen production during the wastewater treatment process by MECs. The suggested strategy contains two main stages: modelling and optimal parameter identification. Firstly, using adaptive neuro-Fuzzy inference system (ANFIS) modelling, an accurate model of the MES was created. Secondly, the optimal parameters of the operating conditions were determined using the jellyfish optimizer (JO). Three operating variables were studied: incubation temperature (°C), initial potential of hydrogen (pH), and influent chemical oxygen demand (COD) concentration (%). Using some measured data points, the ANFIS model was built for simulating the output of MFC considering the operating parameters. Afterward, a jellyfish optimizer was applied to determine the optimal temperature, initial pH, and influent COD concentration values. To demonstrate the accuracy of the proposed strategy, a comparison with previous approaches was conducted. For the modelling stage, compared with the response surface methodology (RSM), the coefficient of determination increased from 0.8953 using RSM to 0.963 using ANFIS, by around 7.56%. In addition, the RMSE decreased from 0.1924 (using RSM) to 0.0302 using ANFIS, whereas for the optimal parameter identification stage, the optimal values were 30.2 °C, 6.53, and 59.98 (%), respectively, for the incubation temperature, the initial potential of hydrogen (pH), and the influent COD concentration. Under this condition, the maximum rate of the hydrogen production is 1.252 m3H2/m3d. Therefore, the proposed strategy successfully increased the hydrogen production from 1.1747 m3H2/m3d to 1.253 m3H2/m3d by around 6.7% compared to RSM.
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Feng, Chia-Hsien, Chi-Hsien Chou, Lea-Yea Chuang, and Chi-Yu Lu. "Identification of the Metabolites of Angiotensin II (1-8) in MES-13 Cells by a Simple NanoLC-MS-MS System: A Preliminary Platform." Analytical Letters 44, no. 7 (May 2011): 1187–96. http://dx.doi.org/10.1080/00032719.2010.511742.
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Tan, Yong Yu, Fionn Woulfe, Griphin Baxter Chirambo, Patrick Henn, Liezel Cilliers, Kayode Philip Fadahunsi, Simon D. Taylor-Robinson, and John O'Donoghue. "Framework to assess the quality of mHealth apps: a mixed-method international case study protocol." BMJ Open 12, no. 10 (October 2022): e062909. http://dx.doi.org/10.1136/bmjopen-2022-062909.
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IntroductionHealthcare professionals (HCPs) often recommend their patients to use a specific mHealth app as part of health promotion, disease prevention and patient self-management. There has been a significant growth in the number of HCPs downloading and using mobile health (mHealth) apps. Most mHealth apps that are available in app stores employ a ‘star rating’ system. This is based on user feedback on an app, but is highly subjective. Thus, the identification of quality mHealth apps which are deemed fit for purpose can be a difficult task for HCPs. Currently, there is no unified, validated standard guidelines for assessment of mHealth apps for patient safety, which can be used by HCPs. The Modified Enlight Suite (MES) is a quality assessment framework designed to provide a means for HCPs to evaluate mHealth apps before they are recommended to patients. MES was adapted from the original Enlight Suite for international use through a Delphi method, followed by preliminary validation process among a population predominantly consisting of medical students. This study aims to evaluate the applicability and validity of the MES, by HCPs, in low, middle and high income country settings.Methods and analysisMES will be evaluated through a mixed-method study, consisting of qualitative (focus group) and quantitative (survey instruments) research, in three target countries: Malaŵi (low income), South Africa (middle income) and Ireland (high income). The focus groups will be conducted through Microsoft Teams (Microsoft, Redmond, Washington, USA) and surveys will be conducted online using Qualtrics (Qualtrics International, Seattle, Washington, USA). Participants will be recruited through the help of national representatives in Malawi (Mzuzu University), South Africa (University of Fort Hare) and Ireland (University College Cork) by email invitation. Data analysis for the focus group will be by the means of thematic analysis. Data analysis for the survey will use descriptive statistics and use Cronbach alpha as an indicator of internal consistency of the MES. The construct validity of the mHealth app will be assessed by computing the confirmatory factor analysis using Amos.Ethics and disseminationThe study has received ethical approval from the Social Research Ethics Committee (SREC) SREC/SOM/03092021/1 at University College Cork, Ireland, Malaŵi Research Ethics Committee (MREC), Malaŵi MZUNIREC/DOR/21/59 and Inter-Faculty Research Ethics Committee (IFREC) of University of Fort Hare (REC-2 70 710-028-RA). The results of the study will be disseminated through the internet, peer-reviewed journals and conference presentations.
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Torres-Sangiao, Eva, Brais Lamas Rodriguez, María Cea Pájaro, Raquel Carracedo Montero, Noelia Parajó Pazos, and Carlos García-Riestra. "Direct Urine Resistance Detection Using VITEK 2." Antibiotics 11, no. 5 (May 15, 2022): 663. http://dx.doi.org/10.3390/antibiotics11050663.
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Urinary tract infections (UTIs) are the most common infectious diseases in both communities and hospitals. With non-anatomical or functional abnormalities, UTIs are usually self-limiting, though women suffer more reinfections throughout their lives. Certainly, antibiotic treatment leads to a more rapid resolution of symptoms, but also it selects resistant uropathogens and adversely affects the gut and vaginal microbiota. As uropathogens are increasingly becoming resistant to currently available antibiotics, it could be time to explore alternative strategies for managing UTIs. Rapid identification and antimicrobial susceptibility testing (AST) allow fast and precise treatment. The objective of this study was to shorten the time of diagnosis of UTIs by combining pathogen screening through flow cytometry, microbial identification by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS), and the VITEK 2 system for the direct analysis of urine samples. First, we selected positive urine samples by flow cytometry using UF5000, establishing the cut-off for positive at 150 bacteria/mL. After confirming the identification using MALDI-TOF MS and filtering the urine samples for Escherichia coli, we directly tested the AST N388 card using VITEK 2. We tested a total of 211 E. coli from urine samples. Cefoxitin, ertapenem, imipenem, gentamicin, nalidixic acid, ciprofloxacin, fosfomycin, and nitrofurantoin had no major important errors (MIE), and ampicillin, cefuroxime, and tobramycin showed higher MIEs. Cefepime, imipenem, and tobramycin had no major errors (ME). Fosfomycin was the antibiotic with the most MEs. The antibiotic with the most minor errors (mE) was ceftazidime. The total categorical agreement (CA) was 97.4% with a 95% CI of (96.8–97.9)95%. The direct AST from the urine samples proposed here was shorter by one day, without significant loss of sensibility regarding the standard diagnosis. Therefore, we hypothesize that this method is more realistic and better suited to human antibiotic concentrations.
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Fedorowicz, Olga, Łukasz Rypicz, Anna Wiela-Hojeńska, Ewa Jaźwińska-Tarnawska, and Izabela Witczak. "Application of Novel Pharmacists’ Risk in Pharmacotherapy (PHARIPH) Scale for Identification of Factors Affecting the Safety of Hospital Pharmacotherapy—An Observational Pilot Study." International Journal of Environmental Research and Public Health 19, no. 3 (January 25, 2022): 1337. http://dx.doi.org/10.3390/ijerph19031337.
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Background: The widespread occurrence of medication errors (MEs) has become a global problem because it poses a serious threat to the health and lives of patients, can prevent the achievement of treatment goals, undermines patient trust in the health care system, and increases treatment costs. The purpose of this study was to develop an appropriate tool to identify key risk factors that hospital pharmacists believe threaten pharmacotherapy safety in the hospital. Methods: A diagnostic survey method using the authors’ PHARIPH (Pharmacists’ Risk in Pharmacotherapy) scale and authorial questions was used to identify risks that may result in patient pharmacotherapy errors at the hospital pharmacist level. A total of 125 Polish hospital pharmacists participated in the study. Results: The original authors’ created PHARIPH scale was characterized by a Cronbach’s alpha coefficient of 0.958. According to the surveyed pharmacists, the greatest threat to pharmacotherapy safety was misreading of a doctor’s order (similar drug nomenclature) and preparing a wrong drug (similar drug packaging, similar drug nomenclature). Female pharmacists compared to male pharmacists attributed significantly higher importance to such risk factors such as pharmacist’s ignorance of a list of drug substitutes (p = 0.047, risk 8), preparation from an expired/withdrawn drug (p = 0.002, risk 14), preparation from a drug stored in inappropriate conditions (p = 0.05, risk 15), preparation of drugs ordered in hospital and PODs (patients’ own drugs) without checking for possible drug duplication (p = 0.011, risk 17) and their potential effect on patient safety. Conclusions: The PHARIPH scale could be applied as a novel tool for identification of pharmacotherapy risks.
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Bandurko, I. A., and Z. Sh Daguzhieva. "Ecological and geographical grouping of pear varieties and identification of new sources for breeding in the conditions of the North Caucasus." New Technologies 16, no. 6 (February 20, 2021): 48–57. http://dx.doi.org/10.47370/2072-0920-2020-16-6-48-57.
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The article presents the results of a long-term study of the world collection of pears, which is one of the largest in the RIPB system. It is kept at the Maykop Experimental Station of the Federal Research Center of the All-Russian Institute of Plant Genetic Resources named after N.I. Vavilov» branch and has 875 varieties, 248 species, forms and varieties, and is constantly updated with new samples. The collection includes wild species, as well as Russian and foreign varieties from Europe, America, Asia. The research was carried out in the soil and climatic conditions of the foothill zone of the North Caucasus in 2005–2015. The aim of the research is to study the dependence of biological traits and properties on the origin of samples and to isolate genotypes with the maximum expression of traits for use in breeding. In the research the methodological instructions of the All-Russian Research Institute of Breeding of Fruit Crops and the North Caucasus Center for the Breeding of Fruit, Berry, Flower and Ornamental Crops and Grapes have been used. The analysis of weather conditions has been carried out using meteorological data of the MES of the RIPB Branch. The regularities of the manifestation of signs and biological properties of the studied samples depending on their geographical origin have been established. The varieties that combine a fairly good quality of fruits and other, valuable characteristics have been identified: late flowering for protection from frost – Obilnaya Tuza, Uspenka; resistance to fungal diseases – Vodnik, Utrennyaya Svezhest; early maturity – Borup, Napoca and high regular yield – P. regelii x P. pyrifolia № 2 interspecific hybrid. As a result of many years of studying the world collection of pears the list of isolated genotypes of valuable traits has been added, the use of which contributes to a significant increase in the efficiency of breeding work.
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Marziali, Elsa. "David C. Burdick and Sunkyo Kwon (Eds.). Gerontechnology: Research and Practice in Technology and Aging. New York: Springer, 2004." Canadian Journal on Aging / La Revue canadienne du vieillissement 25, no. 2 (2006): 237–38. http://dx.doi.org/10.1353/cja.2006.0039.
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RÉSUMÉCe livre est essentiel pour quiconque s'intéresse à l'impact des technologies sur la qualité de vie des personnes âgées. Partant d'un introduction qui illustre clairement que la société dans son ensemble est de plus en plus immergée dans la communication et la transmission d'informations digitales, les chapitres suivants fournissent des données et analyses de l'interface qui existe entre le déclin lié à l'âge et l'acce`s aux technologies spécifiques telles que les ordinateurs, les appareils d'aide fonctionnelle, le monitorage à la maison et les syste`mes interactifs de voix/vidéo sur réseau IP. Le rôle que joue la technologie dans la vie des personnes âgées est bien décrit sur les plans empirique et pratique. De plus, la plupart des chapitres centrent leur attention sur les défis que constitue la conception d'interfaces techniques qui visent spécifiquement les changements visuels, moteurs et cognitifs liés à l'âge. De toute évidence, cet ouvrage peut amener les fournisseurs de services à mieux cerner les différentes façons dont les technologies sont susceptibles d'améliorer et de remodeler la vie d'une société vieillissante.
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Taboada, Jorge, Salvador González-Gordo, María A. Muñoz-Vargas, José M. Palma, and Francisco J. Corpas. "NADP-Dependent Malic Enzyme Genes in Sweet Pepper Fruits: Involvement in Ripening and Modulation by Nitric Oxide (NO)." Plants 12, no. 12 (June 17, 2023): 2353. http://dx.doi.org/10.3390/plants12122353.
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NADPH is an indispensable cofactor in a wide range of physiological processes that is generated by a family of NADPH dehydrogenases, of which the NADP-dependent malic enzyme (NADP-ME) is a member. Pepper (Capsicum annuum L.) fruit is a horticultural product consumed worldwide that has great nutritional and economic relevance. Besides the phenotypical changes that pepper fruit undergoes during ripening, there are many associated modifications at transcriptomic, proteome, biochemical and metabolic levels. Nitric oxide (NO) is a recognized signal molecule with regulatory functions in diverse plant processes. To our knowledge, there is very scarce information about the number of genes encoding for NADP-ME in pepper plants and their expression during the ripening of sweet pepper fruit. Using a data mining approach to evaluate the pepper plant genome and fruit transcriptome (RNA-seq), five NADP-ME genes were identified, and four of them, namely CaNADP-ME2 to CaNADP-ME5, were expressed in fruit. The time course expression analysis of these genes during different fruit ripening stages, including green immature (G), breaking point (BP) and red ripe (R), showed that they were differentially modulated. Thus, while CaNADP-ME3 and CaNADP-ME5 were upregulated, CaNADP-ME2 and CaNADP-ME4 were downregulated. Exogenous NO treatment of fruit triggered the downregulation of CaNADP-ME4. We obtained a 50–75% ammonium–sulfate-enriched protein fraction containing CaNADP-ME enzyme activity, and this was assayed via non-denaturing polyacrylamide gel electrophoresis (PAGE). The results allow us to identify four isozymes designated from CaNADP-ME I to CaNADP-ME IV. Taken together, the data provide new pieces of information on the CaNADP-ME system with the identification of five CaNADP-ME genes and how the four genes expressed in pepper fruits are modulated during ripening and exogenous NO gas treatment.
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van Hedel, Henriëtte. "Towards a European Ius Commune – What Lessons can We Learn from Quebec’s Mixed Legal System?" European Review of Private Law 15, Issue 5 (October 1, 2007): 685–705. http://dx.doi.org/10.54648/erpl2007036.
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Abstract: We are witness today, within a context of an increasingly integrated European Union, the making of a new European private law. This ius commune Europeaum will have to be based on legal foundations that can be adhered to by all member states. In this perspective it is indispensable to investigate whether domestic legal systems of the member states are able to adopt legal concepts of other member states and yet remain cohesive systems. This article analyzes how the Quebec jurisdiction adopted the common law concepts of the trust and the common law doctrine of unconscionability, in order to answer the question whether, and if so how, European civil law jurisdictions may adopt common legal concepts and yet remain cohesive. Résumé: Nous sommes aujourd’hui témoins, dans le cadre d’une Union Européenne de plus en plus intégrée, de l’élaboration d’un nouvel droit civil Européenne. Ce ius commune Europease devra d’être basé sur des fondations juridiques qui pourront être adoptées par tous les états membres. Dans cette perspective, il est primordial d’examiner si les syste`mes juridiques domestiques des états membres peuvent adopter des concepts juridiques d’autres états membres et rester pourtant des syste`mes cohérents. Ce n’est que dans ces circonstances qu’il sera possible de construire l’émergente ius commune sur un cadre juridique conceptuel, qui ne va pas être perc¸u comme un Fremdkörper dans les états participants. Le présent article analyse comment le législateur Québécois a adopté les concepts de common law du trust et de unconscionability afin de comprendre si et comment les juridictions européennes de droit civil peuvent adopter des concepts juridiques de common law et tout en demeurant cohérentes. Zusammenfassung: Trotz einer europäischen Tendenz zur einer nationalen Introversion gestalten EU Juristen weiter ihre gemeinsame Identität in ihrem Bemühen, ein gemeinsames europäische Zivilrecht zu schaffen. Für den Erfolg dieses ius commune Europeaum ist es entscheidend, dass es auf rechtlichen Grundprinzipien basiert, die in allen Mitgliedstaaten wiedergefunden werden können. Im Hinblick hierauf ist es unerlässlich zu untersuchen, ob die nationalen Rechtssysteme der EU Mitgliedstaaten rehtliche Instrumente anderer Mitgliedstaaten in ihr eigenes Rechtssystem übernehmen können, und weiterhin ein geschlossenes System darstellen. Dieser Beitrag analysiert, wie das Recht von Quebec – ein sogenanntes gemischtes Rechtssystem – das aus dem Common Law stammende Rechtsinstrument des Trust sowie die im Common Law enthaltene Doktrin von der Sittenwidrigkeit übernommen hat, um die Frage beantworten zu können, ob, und wenn ja, wie die europäischen Civil Law Rechtssysteme Instrumente des Common Law übernehmen können und weiterhin auch ein geschlossenes System bilden.
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How, Jonathan P. "Nonlinear System Identification [About This Issue]." IEEE Control Systems 39, no. 6 (December 2019): 5–6. http://dx.doi.org/10.1109/mcs.2019.2937256.
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Capowski, E. E., P. Martin, C. Garvin, and S. Strome. "Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans." Genetics 129, no. 4 (December 1, 1991): 1061–72. http://dx.doi.org/10.1093/genetics/129.4.1061.
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Abstract To identify genes that encode maternal components required for development of the germ line in the nematode Caenorhabditis elegans, we have screened for mutations that confer a maternal-effect sterile or "grandchildless" phenotype: homozygous mutant hermaphrodites produced by heterozygous mothers are themselves fertile, but produce sterile progeny. Our screens have identified six loci, defined by 21 mutations. This paper presents genetic and phenotypic characterization of four of the loci. The majority of mutations, those in mes-2, mes-3 and mes-4, affect postembryonic germ-line development; the progeny of mutant mothers undergo apparently normal embryogenesis but develop into agametic adults with 10-1000-fold reductions in number of germ cells. In contrast, mutations in mes-1 cause defects in cytoplasmic partitioning during embryogenesis, and the resulting larvae lack germ-line progenitor cells. Mutations in all of the mes loci primarily affect the germ line, and none disrupt the structural integrity of germ granules. This is in contrast to grandchildless mutations in Drosophila melanogaster, all of which disrupt germ granules and affect abdominal as well as germ-line development.
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Schoukens, Johan, and Lennart Ljung. "Nonlinear System Identification: A User-Oriented Road Map." IEEE Control Systems 39, no. 6 (December 2019): 28–99. http://dx.doi.org/10.1109/mcs.2019.2938121.
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Khadijeh Taghizadeh, Seyedeh, Syed Abidur Rahman, Noor Hazlina Ahmad, and Thurasamy Ramayah. "Psychological Factors of Innovativeness among Nomadic Micro-Entrepreneurs for Achieving Business Growth." Verslas: teorija ir praktika 17, no. 3 (September 29, 2016): 191–201. http://dx.doi.org/10.3846/btp.2016.618.
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The objective of this paper is to explore the psychological factors of innovativeness that drives nomadic micro entrepreneurs’ (MEs) in enhancing their business growth in Malaysia. Nomadic micro entrepreneurs refer to those who regularly change the location of their business. To meet the research objective, the current study carried out in-depth interviews among the Nomadic MEs operating their business in Northern region, Malaysia. Twenty Nomadic MEs were interviewed on voluntary basis. Thematic analysis was conducted to identify the recurring themes that delineate psychological factors that may influence innovativeness. Interestingly, the findings revealed that the innovativeness of Nomadic MEs is influenced by four psychological characteristics namely sense of curiosity, interest, risk taking, and risk avoidance. The contribution of this study lies in the identification of four substantial psychological factors that act as a foundation for innovativeness among nomadic micro entrepreneurs’ (MEs) in enhancing their business growth.
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González, E. J., A. Hamilton, L. Moreno, R. L. Marichal, G. N. Marichal, and J. Toledo. "A MAS IMPLEMENTATION FOR SYSTEM IDENTIFICATION AND PROCESS CONTROL." Asian Journal of Control 8, no. 4 (October 22, 2008): 417–23. http://dx.doi.org/10.1111/j.1934-6093.2006.tb00294.x.
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Mercere, Guillaume. "Technical Committee on System Identification and Adaptive Control [Technical Activities]." IEEE Control Systems 39, no. 3 (June 2019): 21–23. http://dx.doi.org/10.1109/mcs.2019.2900815.
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Formentin, Simone. "Technical Committee on System Identification and Adaptive Control [Technical Activities]." IEEE Control Systems 40, no. 6 (December 2020): 18–20. http://dx.doi.org/10.1109/mcs.2020.3019149.
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Heri Nurdiyanto. "Critical Role of Manufacturing Execution Systems in Digital Transformation of Manufacturing Industry." Journal of Electrical Systems 20, no. 7s (May 4, 2024): 2432–36. http://dx.doi.org/10.52783/jes.4038.
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The manufacturing industry is undergoing a significant digital transformation, propelled by advancements in technology. Central to this evolution is the implementation of Manufacturing Execution Systems (MES), which act as a vital link between the shop floor and enterprise-level systems. This paper explores the critical role of MES in the digital transformation of the manufacturing industry, focusing on how it enhances operational efficiency, improves product quality, and enables real-time decision-making. Manufacturing Execution Systems are software platforms designed to monitor, control, and optimize production processes from the initiation of orders to the delivery of finished goods. MES provides real-time data on production activities, enabling manufacturers to make informed decisions, reduce production costs, and increase overall productivity. The integration of MES with advanced technologies such as the Internet of Things (IoT), Big Data analytics, and cloud computing has further amplified its impact, leading to smarter and more agile manufacturing processes. One of the key benefits of MES is its ability to improve operational efficiency. MES offers real-time visibility into the production process, allowing manufacturers to identify and resolve bottlenecks, minimize downtime, and optimize resource utilization. Predictive maintenance capabilities, enabled by IoT integration, prevent unexpected equipment failures and reduce maintenance costs. MES also plays a crucial role in enhancing product quality. By monitoring each stage of production, MES ensures adherence to quality standards and facilitates traceability. In the event of a quality issue, MES allows for quick identification of the root cause and implementation of corrective actions. Real-time quality checks at critical points in the production process help detect and address defects promptly. Moreover, MES supports real-time decision-making by providing up-to-date data that allows production managers to respond swiftly to changes in demand or production conditions. This agility is essential in today's fast-paced manufacturing environment. In conclusion, Manufacturing Execution Systems are indispensable in the digital transformation of the manufacturing industry. By improving efficiency, product quality, and decision-making capabilities, MES equips manufacturers to succeed in the era of Industry 4.0. This paper highlights the benefits and challenges of MES implementation, offering valuable insights for manufacturers aiming to leverage MES in their digital transformation efforts
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Ahuja, Atula, Suparak Techacharoenrungrueang, and Sudaporn Luksaneeyanawin. "Metaphors of womanhood in the literary works of contemporary Indian writers." Metaphor Variation in Englishes around the World 4, no. 1 (September 22, 2017): 131–58. http://dx.doi.org/10.1075/cogls.4.1.07ahu.
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Abstract This study examines the notion of womanhood in the literary works of contemporary Indian authors by analyzing conceptual metaphors of womanhood. More specifically, the data collected in this study are metaphorical expressions (MEs) from nine fictional works set in India’s three main ethnically and linguistically diverse regions occupied by three linguistic groups, namely, the Indo-Aryan, the Dravidian, and the Tibeto-Burmese. The identification of MEs follows the Metaphor Identification Procedure VU University Amsterdam (MIPVU; Steen et al. 2010a). The analysis focuses on cross-cultural variation in conceptual metaphor, applying Conceptual Metaphor Theory (CMT; Lakoff & Johnson 1980) and the cognitive dimension of socio-cultural diversity proposed by Kövecses (2008). Through the analysis of conceptual metaphor, the paper provides insights into the current social context regarding the status and roles of women in India.
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Ko, Song Yi, Hye Yoon Kang, Hyun Sil Lee, Sang Yeul Han, and Seung Hwan Hong. "Identification of Jmjd1a as a STAT3 Downstream Gene in mES Cells." Cell Structure and Function 31, no. 2 (2006): 53–62. http://dx.doi.org/10.1247/csf.31.53.
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Batselier, Kim. "Low-Rank Tensor Decompositions for Nonlinear System Identification: A Tutorial with Examples." IEEE Control Systems 42, no. 1 (February 2022): 54–74. http://dx.doi.org/10.1109/mcs.2021.3122268.
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Marsyela, Marsyeli, Uswatun Hasanah, Wardatun Thaibah Marpaung, and Sifa Maulida. "Identification of School System Approaches at MAS Al-Washliyah 22 Tembung." Quality : Journal Of Education, Arabic And Islamic Studies 1, no. 2 (November 30, 2023): 136–45. http://dx.doi.org/10.58355/qwt.v1i2.32.
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In this research, we conducted an in-depth analysis of the various systems approaches implemented at the MAS Al-Washliyah Tembung school to improve the quality of education. We identified various aspects of the systems approach, starting from the application of the systems approach in education at the school, the obstacles in explaining the systems approach, elements or components in education, what approaches are used in the learning process and the stages in implementing the systems approach. The systems approach in schools can include analysis of various systems approaches applied in the educational environment. This can include learning approaches, school management, and curriculum development. Through this research, we hope to provide deeper insight into the systems approach that exists at the MAS Alwashliyah 22 Tembung school in the context of school education.
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Reshetnikov, I. S., and R. A. Moshkovich. "BASIC ANALYSIS OF THE APPLICABILITY OF THE VISUAL BIOMETRIC IDENTIFICATION FOR MES." Information Technologies of CAD/CAM/CAE, no. 3 (2022): 21–26. http://dx.doi.org/10.52190/2073-2597_2022_3_21.
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Hart, Lara, Mallory Chavannes, Omar Kherad, Chelsea Maedler, Nathalie Mourad, Victoria Marcus, Waqqas Afif, et al. "Faecal Calprotectin Predicts Endoscopic and Histological Activity in Clinically Quiescent Ulcerative Colitis." Journal of Crohn's and Colitis 14, no. 1 (June 10, 2019): 46–52. http://dx.doi.org/10.1093/ecco-jcc/jjz107.
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Abstract Introduction Faecal calprotectin [FC] is a reliable surrogate marker for disease activity in ulcerative colitis [UC]; however, there are no consensus cut-off values for remission. The study aim was to correlate FC with Mayo Endoscopic Score [MES] and histological disease activity of UC patients in clinical remission. Methods Our study recruited adult UC patients at the McGill IBD Center between 2013 and 2017. Patients in clinical remission [partial Mayo score ≤2], undergoing endoscopy for disease activity or dysplasia surveillance, were enrolled. Before bowel preparation, FC was collected. MES was documented during colonoscopy. Biopsies were taken; histological activity was assessed using Geboes score and the presence of basal plasmacytosis. Results A total of 185 patients were recruited. The area under the curve [AUC] in receiver operating characteristic [ROC] analysis to predict MES 1–3 [from 0] was 0.743 [95% CI 0.67–0.82; p <0.001] with an FC cut-off value 170 µg/g [64% sensitivity, 74% specificity], and to predict MES 2–3 [from 0–1] was 0.722 [95% CI 0.61–0.83; p <0.001] with an FC cut-off value 170 µg/g [69% sensitivity, 65% specificity]. To differentiate MES 0 from MES 1, an FC value 130 µg/g yields a 70% sensitivity and 68% specificity. The AUC in ROC analysis to predict Geboes <3.1 was 0.627 [95% CI 0.55–0.71; p = 0.003], with an FC value 135 µg/g [54% sensitivity, 69% specificity]. Conclusions In this large study, FC ≥170 µg/g predicts endoscopic activity and FC ≥135 µg/g predicts histological activity. Therefore in clinical practice, lower faecal calprotectin thresholds can be chosen to optimise identification of patients with ongoing endoscopic and histological disease activity.
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Tang, Wangxiangfu, and Ping Liang. "The identification of retro-DNAs in primate genomes as DNA transposons mobilizing via retrotransposition." F1000Research 12 (March 9, 2023): 255. http://dx.doi.org/10.12688/f1000research.130043.1.
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Background: Mobile elements (MEs) constitute a major portion of the genome in primates and other higher eukaryotes, and they play important role in genome evolution and gene function. MEs can be divided into two fundamentally different classes: DNA transposons which transpose in the genome in a “cut-and-paste” style, and retrotransposons which propagate in a “copy-and-paste” fashion via a process involving transcription and reverse-transcription. In primate genomes, DNA transposons are mostly dead, while many retrotransposons are still highly active. We report here the identification of a new type of MEs, which we call “retro-DNAs”, for their combined characteristics of these two fundamentally different ME classes. Methods: A comparative computational genomic approach was used to analyze the reference genome sequences of 10 primate species consisting of five apes, four monkeys, and marmoset. Results: From our analysis, we identified a total of 1,750 retro-DNAs, representing 748 unique insertion events in the genomes of ten primate species including human. These retro-DNAs contain sequences of DNA transposons but lack the terminal inverted repeats (TIRs), the hallmark of DNA transposons. Instead, they show characteristics of retrotransposons, such as polyA tails, longer target-site duplications (TSDs), and the “TT/AAAA” insertion site motif, suggesting the use of the L1-based target-primed reverse transcription (TPRT) mechanism. At least 40% of these retro-DNAs locate into genic regions, presenting potentials for impacting gene function. More interestingly, some retro-DNAs, as well as their parent sites, show certain levels of expression, suggesting that they have the potential to create more retro-DNA copies in the present primate genomes. Conclusions: Although small in number, the identification of these retro-DNAs reveals a new mechanism for propagating DNA transposons in primate genomes without active canonical DNA transposon activity. Our data also suggest that the TPRT machinery may transpose a wider variety of DNA sequences in the genomes.
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Tang, Wangxiangfu, and Ping Liang. "The identification of retro-DNAs in primate genomes as DNA transposons mobilizing via retrotransposition." F1000Research 12 (April 16, 2024): 255. http://dx.doi.org/10.12688/f1000research.130043.2.
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Background Mobile elements (MEs) constitute a major portion of the genome in primates and other higher eukaryotes, and they play important role in genome evolution and gene function. MEs can be divided into two fundamentally different classes: DNA transposons which transpose in the genome in a “cut-and-paste” style, and retrotransposons which propagate in a “copy-and-paste” fashion via a process involving transcription and reverse-transcription. In primate genomes, DNA transposons are mostly dead, while many retrotransposons are still highly active. We report here the identification of a new type of MEs, which we call “retro-DNAs”, for their combined characteristics of these two fundamentally different ME classes. Methods A comparative computational genomic approach was used to analyze the reference genome sequences of 10 primate species consisting of five apes, four monkeys, and marmoset. Results From our analysis, we identified a total of 1,750 retro-DNAs, representing 748 unique insertion events in the genomes of ten primate species including human. These retro-DNAs contain sequences of DNA transposons but lack the terminal inverted repeats (TIRs), the hallmark of DNA transposons. Instead, they show characteristics of retrotransposons, such as polyA tails, longer target-site duplications (TSDs), and the “TT/AAAA” insertion site motif, suggesting the use of the L1-based target-primed reverse transcription (TPRT) mechanism. At least 40% of these retro-DNAs locate into genic regions, presenting potentials for impacting gene function. More interestingly, some retro-DNAs, as well as their parent sites, show certain levels of expression, suggesting that they have the potential to create more retro-DNA copies in the present primate genomes. Conclusions Although small in number, the identification of these retro-DNAs reveals a new mechanism for propagating DNA transposons in primate genomes without active canonical DNA transposon activity. Our data also suggest that the TPRT machinery may transpose a wider variety of DNA sequences in the genomes.
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Tang, Wangxiangfu, and Ping Liang. "The identification of retro-DNAs in primate genomes as DNA transposons mobilizing via retrotransposition." F1000Research 12 (May 29, 2024): 255. http://dx.doi.org/10.12688/f1000research.130043.3.
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Background Mobile elements (MEs) constitute a major portion of the genome in primates and other higher eukaryotes, and they play important role in genome evolution and gene function. MEs can be divided into two fundamentally different classes: DNA transposons which transpose in the genome in a “cut-and-paste” style, and retrotransposons which propagate in a “copy-and-paste” fashion via a process involving transcription and reverse-transcription. In primate genomes, DNA transposons are mostly dead, while many retrotransposons are still highly active. We report here the identification of a unique group of MEs, which we call “retro-DNAs”, for their combined characteristics of these two fundamentally different ME classes. Methods A comparative computational genomic approach was used to analyze the reference genome sequences of 10 primate species consisting of five apes, four monkeys, and marmoset. Results From our analysis, we identified a total of 1,750 retro-DNAs, representing 748 unique insertion events in the genomes of ten primate species including human. These retro-DNAs contain sequences of DNA transposons but lack the terminal inverted repeats (TIRs), the hallmark of DNA transposons. Instead, they show characteristics of retrotransposons, such as polyA tails, longer target-site duplications (TSDs), and the “TT/AAAA” insertion site motif, suggesting the use of the L1-based target-primed reverse transcription (TPRT) mechanism. At least 40% of these retro-DNAs locate into genic regions, presenting potentials for impacting gene function. More interestingly, some retro-DNAs, as well as their parent sites, show certain levels of expression, suggesting that they have the potential to create more retro-DNA copies in the present primate genomes. Conclusions Although small in number, the identification of these retro-DNAs reveals a new mean for propagating DNA transposons in primate genomes without active canonical DNA transposon activity. Our data also suggest that the TPRT machinery may transpose a wider variety of DNA sequences in the genomes.
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Duan, Lian, Jun Jie Wu, and Fan Liu. "Research on Automatic Identification of MCS Based on Infrared Satellite Cloud Image of FY2D." Applied Mechanics and Materials 716-717 (December 2014): 954–57. http://dx.doi.org/10.4028/www.scientific.net/amm.716-717.954.
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The mesoscale convective system (MCS) has a great influence on the Aviation flight, this article used infrared satellite cloud image data detected by FY2D and eigenvalue method to research MCS’ identification to accurately identify the MCS cloud. Firstly, satellite image binarization processing and edge detection ,to extract the large boundary gray gradient cloud. Then, calculating cloud’s geometric center coordinates , cloud size ,centroid coordinates, the average TBB values, ellipticity and some other eigenvalue and eigenvector. Finally, selecting those which meet to the MCS identification criterion to realize the automatic identification of MCS.
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Wigren, Anna, Johan Wagberg, Fredrik Lindsten, Adrian G. Wills, and Thomas B. Schon. "Nonlinear System Identification: Learning While Respecting Physical Models Using a Sequential Monte Carlo Method." IEEE Control Systems 42, no. 1 (February 2022): 75–102. http://dx.doi.org/10.1109/mcs.2021.3122269.
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Cohen, L., F. Soto, M. S. Luna, C. R. Pratesi, G. Cassani, and L. Faccetti. "Analysis of sulfoxylated methyl esters (Φ-MES): Sulfonic acid composition and isomer identification." Journal of Surfactants and Detergents 6, no. 2 (April 2003): 151–54. http://dx.doi.org/10.1007/s11743-003-0259-0.
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Zhao, Yi, Shiva Kant, Pravin Kesarwani, Christopher Hubert, Ichiro Nakano, Joseph Fullmer, and Prakash Chinnaiyan. "MODL-02. GLIOMA ORGANOID MODEL PHENOTYPICALLY RECAPITULATES KEY ASPECTS OF MALIGNANT TRANSFORMATION IN GLIOBLASTOMA." Neuro-Oncology 24, Supplement_7 (November 1, 2022): vii291. http://dx.doi.org/10.1093/neuonc/noac209.1130.
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Abstract Glioblastoma (GBM) displays extensive intra-tumoral heterogeneity, serving as a major obstacle for effective treatment. The identification of molecular subtypes offered promise for personalized treatment regimens in GBM, however, it has seen been determined these subtypes are reflective of intra- rather than inter-tumoral heterogeneity, with proneural (PN) and mesenchymal (MES) subtypes corresponding to the infiltrative edge and peri-necrotic core of a tumor, respectively. Further, plasticity between subtypes has been identified, with PN-to-MES transition being described as a mode of resistance. Our laboratory utilizes patient-derived, subtype-specific GBM neurospheres as a model to understand GBM heterogeneity and have previously demonstrated that these models faithfully recapitulate human disease, with PN-neurospheres expressing Olig2, having a metabolic phenotype consistent with low-grade glioma, and an indolent growth pattern in vivo when compared to aggressive, CD44 expressing MES-neurospheres. In parallel, our group demonstrated 3D-organoid models of GBM recapitulate the tumor ecology of this malignancy ex vivo. Therefore, we sought to determine if this model could be utilized to provide a window into the plasticity of GBM molecular subtypes. Consistent with their phenotype when grown as neurospheres, MES-organoids had a homogeneous distribution of proliferating cells and retained CD44 expression. In contrast, cellular heterogeneity emerged in PN organoids that could be morphologically divided into an outer, cell-dense rim and an inner core with a lower cell density. The outer rim, recapitulating a perivascular niche, contained proliferating cells, and the inner core contained necrotic cells, mimicking the hypoxic microenvironment of GBM. Intriguingly, PN organoids retained Olig2 expression in the edge, however, actively transitioned into a MES-like state in the core, expressing CD44 and metabolic reprogramming consistent with malignant transformation. Collectively, these finding support that microenvironment contributes towards PN-MES transition and PN organoid models may serve as a tool to provide a window into specific molecular and metabolic factors contributing towards transformation.
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Annergren, Mariette, Christian A. Larsson, Hakan Hjalmarsson, Xavier Bombois, and Bo Wahlberg. "Application-Oriented Input Design in System Identification: Optimal Input Design for Control [Applications of Control]." IEEE Control Systems 37, no. 2 (April 2017): 31–56. http://dx.doi.org/10.1109/mcs.2016.2643243.
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Chiba, Takayuki, Shunrou Fujiwara, Kazumasa Oura, Kohki Oikawa, Kokei Chida, Masakazu Kobayashi, Kenji Yoshida, et al. "Superb Microvascular Imaging Ultrasound for Cervical Carotid Artery Stenosis for Prediction of the Development of Microembolic Signals on Transcranial Doppler during Carotid Exposure in Endarterectomy." Cerebrovascular Diseases Extra 11, no. 2 (May 25, 2021): 61–68. http://dx.doi.org/10.1159/000516426.
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<b><i>Introduction:</i></b> During exposure of the carotid arteries, embolism from the surgical site is recognized as a primary cause of neurological deficits or new cerebral ischemic lesions following carotid endarterectomy (CEA), and associations have been reported between histological neovascularization in the carotid plaque and both plaque vulnerability and the development of artery-to-artery embolism. Superb microvascular imaging (SMI) enables accurate visualization of neovessels in the carotid plaque without the use of intravenous contrast. This study aimed to determine whether preoperative SMI ultrasound for cervical carotid artery stenosis predicts the development of microembolic signals (MES) on transcranial Doppler (TCD) during exposure of the carotid arteries in CEA. <b><i>Methods:</i></b> Preoperative cervical carotid artery SMI ultrasound followed by CEA under TCD monitoring of MES in the ipsilateral middle cerebral artery was conducted in 70 patients previously diagnosed with internal carotid artery stenosis (defined as ≥70%). First, observers visually identified intraplaque microvascular flow (IMVF) signals as moving enhancements located near the surface of the carotid plaque within the plaque on SMI ultrasonograms. Next, regions of interest (ROI) were manually placed at the identified IMVF signals (or at arbitrary places within the plaque when no IMVF signals were identified within the carotid plaque) and the carotid lumen, and time-intensity curves of the IMVF signal and lumen ROI were generated. Ten heartbeat cycles of both time-intensity curves were segmented into each heartbeat cycle based on gated electrocardiogram findings and averaged with respect to the IMVF signal and lumen ROI. The difference between the maximum and minimum intensities (ID) was calculated based on the averaged IMVF signal (ID<sub>IMVF</sub>) and lumen (ID<sub>l</sub>) curves. Finally, the ratio of ID<sub>IMVF</sub> to ID<sub>l</sub> was calculated. <b><i>Results:</i></b> MES during exposure of the carotid arteries were detected in 17 patients (24%). The incidence of identification of IMVF signals was significantly greater in patients with MES (94%) than in those without (57%; <i>p</i> = 0.0067). The ID<sub>IMVF</sub>/ID<sub>l</sub> ratio was significantly greater in patients with MES (0.108 ± 0.120) than in those without (0.017 ± 0.042; <i>p</i> < 0.0001). The specificity and positive predictive value for the ID<sub>IMVF</sub>/ID<sub>l</sub> ratio for prediction of the development of MES were significantly higher than those for the identification of IMVF signals. Logistic regression analysis revealed that only the ID<sub>IMVF</sub>/ID<sub>l</sub> ratio was significantly associated with the development of MES (95% CI 101.1–3,628.9; <i>p</i> = 0.0048). <b><i>Conclusion:</i></b> Preoperative cervical carotid artery SMI ultrasound predicts the development of MES on TCD during exposure of the carotid arteries in CEA.
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ZHENG, HUA-LIN, YUE-PAI WANG, and XI-YUAN WAN. "RFID-BASED SYNCHRONIZATION OF INFORMATION FLOW AND MATERIAL FLOW." Journal of Advanced Manufacturing Systems 07, no. 02 (December 2008): 271–74. http://dx.doi.org/10.1142/s0219686708001553.
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RFID (Radio Frequency Identification) technology is put forward as a new data collection method to bridge the gap between information flow and material flow. The data achieved by RFID can be shared by both MES and ERP simultaneously. A simulated WIP (Work In Process) machining process application case study is used in the paper to show how the synchronization is realized.
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Xiang, Ruxuanyi, Tao Xie, Shuying Bai, Xuehong Zhang, Jian Li, Minghua Wang, and Chao Wang. "Monitoring Mesoscale Convective System Using Swin-Unet Network Based on Daytime True Color Composite Images of Fengyun-4B." Remote Sensing 15, no. 23 (November 30, 2023): 5572. http://dx.doi.org/10.3390/rs15235572.
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The monitoring of mesoscale convective systems (MCS) is typically based on satellite infrared data. Currently, there is limited research on the identification of MCS using true color composite cloud imagery. In this study, an MCS dataset was created based on the true color composite cloud imagery from the Fengyun-4B geostationary meteorological satellite. An MCS true color composite cloud imagery identification model was developed based on the Swin-Unet network. The MCS dataset was categorized into continental MCS and oceanic MCS, and the model’s performance in identifying these two different types of MCS was examined. Experimental results indicated that the model achieved a recall rate of 83.3% in identifying continental MCS and 86.1% in identifying oceanic MCS, with a better performance in monitoring oceanic MCS. These results suggest that using true color composite cloud imagery for MCS monitoring is feasible, and the Swin-Unet network outperforms traditional convolutional neural networks. Meanwhile, we find that the frequency and distribution range of oceanic MCS is larger than that of continental MCS, and the area is larger and some parts of it are stronger. This study provides a novel approach for satellite remote-sensing-based MCS monitoring.
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Anuradha Phadke ,Subrata Kumar Das, Vidya Patil ,. "Hue Channel Mesoscale Convective System Identification Techniques using Kalpana Geostationary Satellite Observations." Journal of Electrical Systems 20, no. 1s (March 28, 2024): 175–89. http://dx.doi.org/10.52783/jes.763.
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Climate change is leading to sudden extreme weather events like floods and heavy rain to occur. One of the most significant rain-bearing systems, Mesoscale Convective Systems (MCSs), is in charge of catastrophic rainfall and flood events that may cause loss of life and property. MCSs are one of the vital components of the climate system on Earth. Many studies contributed to two significant steps, MCS identification and tracking. There are a variety of algorithms focused on tracking whereas for MCS identification only limited methods are present. They contribute to global as well as regional climate patterns by transporting heat and moisture. It is necessary to identify MCS properly to track MCS occurrences over time and comprehend their typical lifecycle to get early warnings of their existence. Three MCS identification techniques based on the Hue channel of the Hue Saturation Value (HSV) color model are implemented in this research, and their effectiveness is assessed. These techniques execute segmentation based on Hue channel Thresholding (HT), K means clustering combined with Hue channel Thresholding (KMCHT) and the modified Source Apportionment Technique combined with Hue channel Thresholding (SATHT). Image pixel values are used to depict infrared brightness temperature data obtained from the Indian geostationary satellite Kalpana-1. The generated ground truth images and performance measurements are used to assess the effectiveness of the methods. The proposed SATHT method for multiple cloud segmentation results in superior performance metrics than the HT and KMCHT approaches.
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Naidu, Sushma V., Harsha R., and Jyothsnya S. "To evaluate the anticonvulsant activity of ethanolic extract of Moringa oleifera (drumstick leaves) in albino mice." International Journal of Basic & Clinical Pharmacology 6, no. 10 (September 23, 2017): 2491. http://dx.doi.org/10.18203/2319-2003.ijbcp20174382.
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Background: To evaluate the anti-convulsant activity of ethanolic extract of Moringa oleifera (Drum stick leaves) in seizure induced albino mice and to compare it with standard drug Sodium valproate.Methods: Swiss albino mice of either sex weighing around 25-30g were randomly selected and divided into four groups of six mice each. Group 1: control- treated with gum acacia. Group 2: Standard - Valproic acid 40mg/kg body weight. Group 3: T1- ethanolic extract of Moringa oleifera (150mg/kg). Group 4: T2 - ethanolic extract of Moringa oleifera (300mg/kg). All drugs were administered orally one hour prior to induction of seizure. The anticonvulsant activity was screened using maximal electroshock seizure (MES) model and pentylenetetrazole (PTZ) model.Results: Results were analysed by ANOVA followed by Bonferroni’s post hoc test. Abolition of Tonic hind limb extension was taken as the protective end point against MES induced seizures and prolongation of seizure latency in PTZ model.At both the doses the ethanolic extract of Moringa oleifera significantly (p value <0.05) reduced the duration of hind limb extension in MES test and also significantly (p value <0.05) delayed the onset of clonic seizures in PTZ induced convulsion when compared with control group.Conclusions: On comparing the percentage protection offered by Moringa oleifera leaves against both MES and PTZ model, it possesses significant anticonvulsant activity at both doses, with more efficacy at 300mg/kg BW indicating that the test drug can prove a very promising drug for treatment of epilepsy. Further studies are required for isolation and identification of the active constituent.
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Lee, Phil Hyu, Seung Hyeon Yeo, Hyun Joon Kim, and Hyo Young Youm. "Correlation between cardiac123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy." Movement Disorders 21, no. 11 (2006): 1975–77. http://dx.doi.org/10.1002/mds.21083.
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Sekione Reward Jeremiah, Sekione Reward Jeremiah, Oscar Enrique Llerena Castro Sekione Reward Jeremiah, Pradip Kumar Sharma Oscar Enrique Llerena Castro, and Jong Hyuk Park Pradip Kumar Sharma. "CCTV Footage De-identification for Privacy Protection: A Comprehensive Survey." 網際網路技術學刊 25, no. 3 (May 2024): 379–86. http://dx.doi.org/10.53106/160792642024052503004.
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<p>Privacy preservation is a significant concern in our data-driven society, both in the social and political spheres. These concerns are amplified by the continuous emergence of technologies and services, expanding the boundaries of what is possible in our modern era. Technologies, such as audio-video surveillance, play an essential role in security and law enforcement but can potentially lead to privacy breaches. One of the approaches for privacy preservation in still images and video is de-identification which involves replacing or concealing personal identifiers to prevent unauthorized, unintended use or disclosure of personal information. This paper comprehensively reviews privacy and security issues in closed-circuit television (CCTV) data streams, representative state-of-the-art de-identification techniques for privacy protection. We also present a service scenario in which a MEC-enabled distributed system is used for CCTV footage de-identification and re-identification for individuals’ privacy protection. Finally, we highlight open research challenges and future directions for privacy protection in CCTV footage.</p> <p> </p>
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Tabariès, Sébastien, Jérôme Lapointe, Terri Besch, Marcelle Carter, John Woollard, Christopher K. Tuggle, and Lucie Jeannotte. "Cdx Protein Interaction with Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton." Molecular and Cellular Biology 25, no. 4 (February 15, 2005): 1389–401. http://dx.doi.org/10.1128/mcb.25.4.1389-1401.2005.
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ABSTRACT Hox gene functions are intimately linked to correct developmental expression of the genes. The identification of cis-acting regulatory sequences and their associated trans-acting factors constitutes a key step in deciphering the mechanisms underlying the correct positioning of the functional domain of Hox genes along the anterior-posterior axis. We have identified DNA elements driving Hoxa5 regionalized expression in mice, using the 2.1-kb mesodermal enhancer (MES) localized in Hoxa5 3′ flanking sequences as a starting point. The MES sequence comprises regulatory elements targeting Hoxa5 expression in the limbs, the urogenital and gastrointestinal tracts, and the cervical-upper thoracic region of the prevertebral column. A 164-bp DNA fragment within the MES caudally restricts Hoxa5 expression at the level of prevertebra 10, corresponding to the posterior limit of its functional domain. Cdx proteins directly bind to this element in vitro via two conserved sites. Preventing Cdx binding by mutating the sites causes caudal expansion of the transgene expression domain. Of all three murine Cdx proteins that bind this element in vitro, Cdx4 has emerged as a potential regional posterior repressor of Hoxa5 expression. The restrictive control provided by Cdx interactions with Hoxa5 regulatory sequences may be one of the critical events in cervicothoracic axial specification.