Academic literature on the topic 'IK1'

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Journal articles on the topic "IK1"

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Opdyke, C. A., and R. L. Calabrese. "Outward currents in heart motor neurons of the medicinal leech." Journal of Neurophysiology 74, no. 6 (1995): 2524–37. http://dx.doi.org/10.1152/jn.1995.74.6.2524.

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1. Outward currents were studied in isolation in heart motor neurons in the medicinal leech, using the single-electrode voltage-clamp technique. The currents were divided into four distinct types on the basis of their time and voltage characteristics and sensitivity to external Ca2+ concentration. 2. The four types were a fast transient current, IKA; a slow transient current. IK1; a noninactivating current, IK2, all measured in a bathing solution in which Co2+ was substituted for Ca2+; and a calcium-sensitive current. IK1Cal which was revealed in a bathing solution containing normal levels of
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Yagi, Tomohito, Shigeyoshi Hibi, Mami Takanashi, et al. "High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis." Blood 99, no. 4 (2002): 1350–55. http://dx.doi.org/10.1182/blood.v99.4.1350.

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While studying Ikaros proteins in childhood acute myeloid leukemia (AML), Ikaros isoform 6 (Ik6) expression was detected in 7 of 10 cases of M4 and M5 leukemia, but in none of the remaining French-American-British subtypes (M2, 8 cases; M7, 6 cases). The spliced Ikaros isoforms 4 to 8 (Ik4-8) suppress the function of full-length Ik1 or Ik2 in a dominant-negative manner, owing to their reduced numbers of DNA binding sites. Thus, dominant-negative Ikaros isoforms may inhibit the normal transcriptional regulation of hematopoietic cell development. To clarify the function of Ik6 in developing bloo
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Vaidyanathan, Ravi, Yogananda S. Markandeya, Timothy J. Kamp, Jonathan C. Makielski, Craig T. January, and Lee L. Eckhardt. "IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 11 (2016): H1611—H1621. http://dx.doi.org/10.1152/ajpheart.00481.2015.

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Currently available induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) do not ideally model cellular mechanisms of human arrhythmic disease due to lack of a mature action potential (AP) phenotype. In this study, we create and characterize iPS-CMs with an electrically mature AP induced by potassium inward rectifier ( IK1) enhancement. The advantages of IK1-enhanced iPS-CMs include the absence of spontaneous beating, stable resting membrane potentials at approximately −80 mV and capability for electrical pacing. Compared with unenhanced, IK1-enhanced iPS-CMs calcium transient amplitu
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Thompson, Jill, and Ted Begenisich. "Membrane-delimited Inhibition of Maxi-K Channel Activity by the Intermediate Conductance Ca2+-activated K Channel." Journal of General Physiology 127, no. 2 (2006): 159–69. http://dx.doi.org/10.1085/jgp.200509457.

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The complexity of mammalian physiology requires a diverse array of ion channel proteins. This diversity extends even to a single family of channels. For example, the family of Ca2+-activated K channels contains three structural subfamilies characterized by small, intermediate, and large single channel conductances. Many cells and tissues, including neurons, vascular smooth muscle, endothelial cells, macrophages, and salivary glands express more than a single class of these channels, raising questions about their specific physiological roles. We demonstrate here a novel interaction between two
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Panama, Brian K., Meredith McLerie, and Anatoli N. Lopatin. "Heterogeneity of IK1 in the mouse heart." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 6 (2007): H3558—H3567. http://dx.doi.org/10.1152/ajpheart.00419.2007.

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Previous studies have shown that cardiac inward rectifier potassium current ( IK1) channels are heteromers of distinct Kir2 subunits and suggested that species- and tissue-dependent expression of these subunits may underlie variability of IK1. In this study, we investigated the contribution of the slowly activating Kir2.3 subunit and free intracellular polyamines (PAs) to variability of IK1 in the mouse heart. The kinetics of activation was measured in Kir2 concatemeric tetramers with known subunit stoichiometry. Inclusion of only one Kir2.3 subunit to a Kir2.1 channel led to an approximate th
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Wahler, G. M. "Developmental increases in the inwardly rectifying potassium current of rat ventricular myocytes." American Journal of Physiology-Cell Physiology 262, no. 5 (1992): C1266—C1272. http://dx.doi.org/10.1152/ajpcell.1992.262.5.c1266.

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The neonatal rat ventricular action potential has a shape similar to that of most adult mammals. However, shortly after birth, the action potential shortens to a spike-like configuration. The contribution of changes in repolarizing currents to the shortening is unclear. Thus the inwardly rectifying potassium current (IK1) was measured in heart cells from rats of varying ages using patch-clamp techniques. In freshly isolated cells, whole cell IK1 currents increased greatly between ages 3 and 9-13 days and remained constant thereafter. In culture, IK1 disappeared preferentially in older cells, o
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Romanenko, Victor G., Kurt S. Roser, James E. Melvin, and Ted Begenisich. "The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels." American Journal of Physiology-Cell Physiology 296, no. 4 (2009): C878—C888. http://dx.doi.org/10.1152/ajpcell.00438.2008.

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Recently, we demonstrated a novel interaction between large-conductance (maxi-K or KCa1.1) and intermediate-conductance (IK1 or KCa3.1) Ca2+-activated K channels: activation of IK1 channels causes the inhibition of maxi-K activity (Thompson J and Begenisich T. J Gen Physiol 127: 159–169, 2006). Here we show that the interaction between these two channels can be regulated by the membrane cholesterol level in parotid acinar cells. Depletion of cholesterol using methyl-β-cyclodextrin weakened, while cholesterol enrichment increased, the ability of IK1 activation to inhibit maxi-K channels. Choles
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Masuda, H., and N. Sperelakis. "Inwardly rectifying potassium current in rat fetal and neonatal ventricular cardiomyocytes." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 4 (1993): H1107—H1111. http://dx.doi.org/10.1152/ajpheart.1993.265.4.h1107.

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Whole cell and single-channel inwardly rectifying potassium currents (IK1) of freshly isolated single fetal (12 and 18 days) and neonatal (1, 5, and 10 days) rat ventricular myocytes were recorded using patch-clamp techniques. Whole cell IK1 was elicited by hyperpolarizing test pulses from a holding potential of -40 mV. IK1 densities increased markedly during heart development between fetal day 12 and until neonatal day 5; there was no further increase on neonatal day 10. Cell-attached patch recordings of single IK1 channels were employed with 150 mM K+ both in the pipette and bath solutions.
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Cheng, Lu-Feng, Fuzhen Wang, and Anatoli N. Lopatin. "Metabolic stress in isolated mouse ventricular myocytes leads to remodeling of t tubules." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 5 (2011): H1984—H1995. http://dx.doi.org/10.1152/ajpheart.00304.2011.

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Cardiac ventricular myocytes possess an extensive t-tubular system that facilitates the propagation of membrane potential across the cell body. It is well established that ionic currents at the restricted t-tubular space may lead to significant changes in ion concentrations, which, in turn, may affect t-tubular membrane potential. In this study, we used the whole cell patch-clamp technique to study accumulation and depletion of t-tubular potassium by measuring inward rectifier potassium tail currents ( IK1,tail), and inward rectifier potassium current ( IK1) “inactivation”. At room temperature
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Poelzing, Steven, and Rengasayee Veeraraghavan. "Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H3043—H3051. http://dx.doi.org/10.1152/ajpheart.01312.2006.

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It was previously demonstrated that transmural electrophysiological heterogeneities can inscribe the ECG T wave. However, the bifurcated T wave caused by loss of inward rectifier potassium current ( IK1) function is not fully explained by transmural heterogeneities. Since right ventricular (RV) guinea pig myocytes have significantly lower IK1 than left ventricular (LV) myocytes, we hypothesized that the complex ECG can be inscribed by heterogeneous chamber-specific responses to hypokalemia and partial IK1 blockade. Ratiometric optical action potentials were recorded from the epicardial surface
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Dissertations / Theses on the topic "IK1"

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Henry, Patrick. "Inhibition du canal potassique a rectification entrante(ik1) par l'ischemie myocardique. Role de la proteine kinase c." Paris 11, 1997. http://www.theses.fr/1997PA112104.

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Nous avons mis au point, valide puis d'exploite un modele d'ischemie sur cellule cardiaque isolee. Ce modele consiste en l'apposition reversible, sur une cellule myocardique isolee, d'une goutte d'huile minerale par un microejecteur preforme. La goutte d'huile constitue une barriere entre la cellule et le milieu exterieur et simule alors une ischemie. Ce modele a permis de realiser une etude electrophysiologique par la technique du patchclamp de cellules ventriculaires isolees de rats soumises a une simulation d'episodes d'ischemie et de reperfusion. L'ischemie induit une activation du canal p
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Zeileis, Achim, and Roger Koenker. "Econometrics in R: Past, Present and Future." Foundation for Open Access Statistics, 2008. http://dx.doi.org/10.18637/jss.v027.i01.

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Recently, computational methods and software have been receiving more attention in the econometrics literature, emphasizing that they are integral components of modern econometric research. This has also promoted the development of many new econometrics software packages written in R and made available on the Comprehensive R Archive Network. This special volume on "Econometrics in R" features a selection of these recent activities that includes packages for econometric analysis of cross-section, time series and panel data. This introduction to the special volume highlights the contents of the
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de, Leeuw Jan, and Patrick Mair. "An Introduction to the Special Volume on "Psychometrics in R"." Foundation for Open Access Statistics, 2007. http://dx.doi.org/10.18637/jss.v020.i01.

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Tucher, von Simmelsdorf Elisabeth Maria [Verfasser]. "Therapieoptionen bei der Behandlung des invasiven Zervixkarzinoms FIGO IA1 L1- IB1 bei Patientinnen im fertilen Alter / Elisabeth Freifrau Tucher von Simmelsdorf." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1029848718/34.

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Holm, Ludvig. "IKT i förskolan : Förskollärares inställning till IKT." Thesis, Södertörns högskola, Lärarutbildningen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-29251.

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The purpose of this study is to take a closer look into preschool teachers interest of ICT, how often do they use digital tools in their practice and what do they think of implementing ICT into their daily work. I’m also interested to see if a certain culture that either is positive or negative towards the use of ICT develops in preschools. What interest do preschool teachers have for ICT? Do preschool teachers think they have sufficient knowledge about ICT? Is a certain culture created within preschools that either is positive or negative towards the use of ICT? I used a quantitative survey
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Calao, Miriam. "Role of IkB kinase (IKK) complex post-translational modifications in NF-kB signaling and therapeutic applications for the treatment of HIV-1 infection." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210318.

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Les facteurs de transcription de la famille Rel/NF-κB régulent l’expression d’un grand nombre de gènes impliqués dans les réponses immunitaires et inflammatoires ainsi que dans la régulation de la prolifération et de la survie cellulaire. Le caractère transitoire de l’activation de NF-κB est donc crucial pour poterger les cellules de l’autoxicité due à une trop forte expression des gènes cibles de ce facteur de transcription. Dans le cadre de notre thèse de doctorat, nous avons étudié les mécanismes moléculaires régulant la cinétique d’activation de NF-κB, en accordant une attention toute part
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Gingdal, Chanette. "Kompetensutveckling inom IKT Skolutvecklares uppfattning av kompetensutveckling inom IKT." Thesis, Mittuniversitetet, Avdelningen för utbildningsvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-21806.

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Franzén, Kristina, and Rebecca Maritz. "IKT i förskolan : Pedagogers attityder till IKT i förskolan." Thesis, Linnéuniversitetet, Institutionen för utbildningsvetenskap (UV), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34509.

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Studiens syfte är att undersöka pedagogers attityd till IKT i förskolan Vi ska även se vad det finns för hinder och möjligheter med IKT i förskolan. Vi har gjort intervjuer på fem olika förskolor för att studera pedagogernas syn på IKT. Vi undersöker också pedagogernas syfte till att använda sig av IKT i förskolan.Den viktigaste delen i vår studie är pedagogen syn och förhållningssätt till att införa teknik och IKT i förskolan. Lindahl & Folkesson (2012) skriver att de senaste fem decennierna har IKT-användningen ökat men är fortfarande inte så etablerade i förskolan. De skriver också att
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Moreira, Larissa Bueno Polis. "Aumento da expressão das isoformas Ik6 e Ik10 do gene IKZF1 ao diagnóstico e seu impacto no prognóstico da leucemia linfoide aguda da infância." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-08012019-163609/.

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Introdução: A leucemia linfoide aguda (LLA) \"BCR-ABL1-like\" exibe um perfil de expressão gênica semelhante ao observado em pacientes com LLA BCR-ABL1+. Este subtipo representa até 15% de todos os casos de LLA de linhagem B na população pediátrica e é frequentemente associado à presença de deleção total ou parcial do gene IKZF1. As isoformas de domínio negativo têm sido associadas a um aumento na chance de falha de resposta ao tratamento e tem sido associada com pior prognóstico. Objetivos: Analisar a presença de deleções do gene IKZF1 e a expressão de suas isoformas em amostras de medula óss
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Loro, Loro Maria Teresa Loro Loro. "IKT i matematikundervisning : Fördelar och nackdelar med användningen av IKT." Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-37394.

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Syftet med denna studie är att undersöka och ta reda på vilka digitala verktyg används i matematikundervisningen i årskurs F-3, hur dessa verktyg används samt vilka för- och nackdelar lärare ser med användningen av digitala verktyg. Resultatet visar att de lärare som undervisar i F-3 använder sig av datorer, Ipads och smartboard i klassrummet. De fem lärare som intervjuades är överens om att IKT underlättar undervisningen, att man kan motivera elever lättare och jobba mer varierat. De anser att det är ett bra komplement att nå kunskapskraven, det öppnar nya möjligheter att nå eleverna och de s
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Books on the topic "IK1"

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Sagara, Atsuko. Yo jiki niwa nido chansu ga aru: Fukkatsu suru kodomotachi. Ko dansha, 1999.

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Dzi︠a︡tlikovich, Viktar. Ikh Mroi︠a︡, ikh N.R.M. Suchasny litaratar, 2005.

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Rainā, Guracarana Siṅgha. Ika drishaṭī, ika samālocanāṃ. Naishanala Buka Shāpa, 1990.

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Rainā, Guracarana Siṅgha. Ika drishaṭī, ika samālocanāṃ. Naishanala Buka Shāpa, 1990.

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Kanada iki-iki oigurashi. Shūeisha, 2000.

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Tōkyō Ika Daigaku. Dōsōkai. Shichijūnenshi Henshū Iinkai. Tōkyō Ika Daigaku Dōsōkai shichijūnenshi. Tōkyō Iks Daigaku Dōsōkai, 1989.

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Timbang, A. Mohammad. Ika. Dewan Bahasa dan Pustaka Brunei, Kementerian Kebudayaan, Belia dan Sukan, 1995.

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Korda, Michael. Ike. HarperCollins, 2007.

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Ikʻ. Siesta, 2008.

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Dumlupınar: Iki gemi iki kaptan. Doğan Kitap, 2007.

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Book chapters on the topic "IK1"

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Sampson, Kevin J., and Robert S. Kass. "K+ Channelopathies (IKs, IKr, and Ito)." In Electrical Diseases of the Heart. Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4881-4_14.

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Viso, Michel. "IKI." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_1781.

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Viso, Michel. "IKI." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1781-2.

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Viso, Michel. "IKI." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1781.

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Donati, Pierpaolo. "Introduction." In Transcending Modernity with Relational Thinking. Routledge, 2021. http://dx.doi.org/10.4324/9781003146698-in1.

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Alpar, Paul, Heinz Lothar Grob, Peter Weimann, and Robert Winter. "IKS-Controlling und Bewertung von IKS." In Anwendungsorientierte Wirtschaftsinformatik. Vieweg+Teubner Verlag, 2005. http://dx.doi.org/10.1007/978-3-322-91909-0_6.

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Appleton, Kathryn M., Ian Cushman, Yuri K. Peterson, et al. "IkB-zeta." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100643.

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Alpar, Paul, Heinz Lothar Grob, Peter Weimann, and Robert Winter. "IKS-Ebene." In Anwendungsorientierte Wirtschaftsinformatik. Vieweg+Teubner Verlag, 2005. http://dx.doi.org/10.1007/978-3-322-91909-0_10.

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G. Wiley, Terrence. "Outside In1." In A Sociolinguistics of the South. Routledge, 2021. http://dx.doi.org/10.4324/9781315208916-4.

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Sommer, Jörg, and Joachim Scharf. "IKR Simulation Library." In Modeling and Tools for Network Simulation. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12331-3_4.

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Conference papers on the topic "IK1"

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Marinov, Peter, Alfonso Bueno-Orovio, and Blanca Rodriguez. "The Role of the Ina-Ik1 Complex on Human Ventricular Conduction Velocity." In 2017 Computing in Cardiology Conference. Computing in Cardiology, 2017. http://dx.doi.org/10.22489/cinc.2017.249-270.

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Ito, Kazufumi, and Karl Kunisch. "Nonsmooth Optimization Method for Image Restoration." In ASME 1995 Design Engineering Technical Conferences collocated with the ASME 1995 15th International Computers in Engineering Conference and the ASME 1995 9th Annual Engineering Database Symposium. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/detc1995-0673.

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Abstract In this paper we discuss applications of the numerical optimization methods for nonsmooth optimization, developed in [IK1] for the variational formulation of image restoration problems involving bounded variation type energy criterion. The Uzawa’s algorithm, first order augmented Lagrangian methods and Newton-like update using the active set strategy are described.
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van Putten, Rosalie ME Meijer, Isabella Mengarelli, Kaomei Guan, et al. "Real-time simulation of IK1 in cardiomyocytes derived from human induced pluripotent stem cells." In 2015 Computing in Cardiology Conference (CinC). IEEE, 2015. http://dx.doi.org/10.1109/cic.2015.7408610.

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ISHIHARA, KEIKO. "TWO MODES OF POLYAMINE BLOCK REGULATING THE CARDIAC K+ CURRENT IK1 AS REVEALED BY A STUDY OF THE KIR2.1 CHANNEL." In Proceedings of the 31st International Congress on Electrocardiology. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812702234_0067.

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Ahn, R. M. C., G. P. J. Baggermans, Y. A. Dijkhuizen, N. Molenaar, and L. Scholten. "IKE." In the 2nd European Union symposium. ACM Press, 2004. http://dx.doi.org/10.1145/1031419.1031421.

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Berlev, I., O. Smirnova, P. Sorokin, et al. "EP258 Long – term outcomes of laparoscopic radical hysterectomy (type III PIVER) for early stage cervical cancer (IA1-IB1 FIGO)." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.319.

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Nogueira, Emilia Alves, Ernani Viriato de Melo, Elaine Ribeiro de Faria, and Denise Guliato. "IKB-MS." In Webmedia '15: 21st Brazilian Symposium on Multimedia and the Web. ACM, 2015. http://dx.doi.org/10.1145/2820426.2820430.

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Sommerer, C., L. Mignonneau, and R. Lopez-Gulliver. "IKI-IKI phone: a multi-user alife art game for mobile phones." In IEEE International Conference on Multimedia and Expo, 2001. ICME 2001. IEEE, 2001. http://dx.doi.org/10.1109/icme.2001.1237678.

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"Session IC1: Integrated circuits 1." In 2013 International Semiconductor Conference (CAS 2013). IEEE, 2013. http://dx.doi.org/10.1109/smicnd.2013.6688647.

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"Session IP1: Image processing (I)." In 2012 Seventh International Conference on Computer Engineering & Systems (ICCES). IEEE, 2012. http://dx.doi.org/10.1109/icces.2012.6408499.

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Reports on the topic "IK1"

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Harkins, D., and D. Carrel. The Internet Key Exchange (IKE). RFC Editor, 1998. http://dx.doi.org/10.17487/rfc2409.

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Fu, D., and J. Solinas. ECP Groups For IKE and IKEv2. RFC Editor, 2007. http://dx.doi.org/10.17487/rfc4753.

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Kivinen, T., B. Swander, A. Huttunen, and V. Volpe. Negotiation of NAT-Traversal in the IKE. RFC Editor, 2005. http://dx.doi.org/10.17487/rfc3947.

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Teo, Marissa. IKK and Beta-Catenin in Breast Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada407807.

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Teo, Marissa. IKK and (Beta)-Catenin in Breast Cancer. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada425896.

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Pauly, T., S. Touati, and R. Mantha. TCP Encapsulation of IKE and IPsec Packets. RFC Editor, 2017. http://dx.doi.org/10.17487/rfc8229.

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Richardson, M., and D. H. Redelmeier. Opportunistic Encryption using the Internet Key Exchange (IKE). RFC Editor, 2005. http://dx.doi.org/10.17487/rfc4322.

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Li, Chia-Wei. Role of IKK-alpha in the EGFR Signaling Regulation. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada612726.

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Schiffbänker, Helene, and Birgit Woitech. Begleitende Evaluierung der IT-Lounge und des IKT-Programms. Joanneum Research, 2002. http://dx.doi.org/10.22163/fteval.2002.243.

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Michels, R., V. Diogo, W. H. G. J. Hennen, and L. F. Puister. Instrumentarium Kosten Natuurbeleid 2018 - Status A : IKN versie 3.0. Wettelijke Onderzoekstaken Natuur & Milieu, 2018. http://dx.doi.org/10.18174/465848.

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