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Dissertations / Theses on the topic 'Lymfomy'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Fredriksson, Sofie. "Bestämning av utfallet av translokationen t(11;18)(q21;q21) hos patienter med MALT-lymfom genom FISH analys." Thesis, University of Kalmar, School of Pure and Applied Natural Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-577.

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<p>Lymphoma is a group of malignant tumour diseases developing in the secondary lymphatic system. These diseases can develop in all organs as lymphocytes are ubiquitously in the body. In connection to mucus membranes we find mucosa-associated lymphoid tissue, MALT, in which lymphoma can spontaneously but slowly develop, mostly at chronic inflammation or at autoimmune diseases. Today these diseases are incureable with the exception of some cases caused by <em>Helicobacter pylori</em>-infection. Antibiotic treatment of these cases can induce remissions.MALT-lymphomas have characteristic histolog
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2

Skog, Emma. "Betydelsen av interleukin 4 receptorn (IL-4R) i stimulering av lymfom- och leukemiceller." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24758.

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Cytokiner eller interleukiner är signalpeptider med låg molekylär vikt somreglerar många viktiga funktioner. De kan delas in i två grupper beroende på deraseffekt på celler. Interleukin 4 (IL-4) till exempel kan tillhöra gruppentillväxtfaktorer medan interleukin 6 (IL-6) kan tillhöra gruppen aktiverings- ellerdifferentieringsfaktorer. IgM-receptorn eller B-cellsreceptorn, BCR, finns på Bcelleroch är membranbundna immunoglobuliner (mIg) som har tvåhuvuduppgifter; att förmedla signaler som styr B-cellens utveckling samt att bindain antigen som sedan ska presenteras för T-celler. I studien aktive
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3

Geete, Järvekülg. "Fertilitet efter behandling av Hodgkins lymfom med olika kombinationer av cytostatika (ABVD och BECOPP)." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76292.

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Hodgkins lymfom är en cancersjukdom som uppstår i det lymfatiska systemet och i Sverige är det ungefär 200 personer per år som insjuknar. Majoriteten av de insjuknade är mellan 15-34 år och ungefär 90% med diagnosen blir botade. Behandlingsformen för Hodgkins lymfom varierar beroende på stadie och då även vilka substanser som ingår i behandlingen. Alkylerande substanser, till exempel prokarbazin och cyklofosfamid, är substanser som är icke-cell-cykelspecifika och förhindrar DNA syntes. Detta kan leda till azoospermi hos männen och reducerad population av ursprungfolliklar hos kvinnor. På grund
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4

Stroeken, Peter Johannes Marie. "Adhesion molecules in lymphoma cell migration and metastasis the role of the [beta]1 integrin cytoplasmic domain /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/61380.

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5

Bergfoth, Emelie, and Maria Eriksson. "Livskvalitet efter avslutad behandling hos dem som drabbats av leukemi, lymfom eller hjärntumör under barn- och ungdomsåren – en litteraturstudie." Thesis, Uppsala University, Department of Public Health and Caring Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112121.

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<p><strong>Syfte</strong></p><p>Syftet med denna litteraturstudie var att undersöka livskvaliteten hos de som drabbats av leukemi, lymfom eller hjärntumör under barndomen och som överlevt denna sjukdom.</p><p><strong>Metod</strong></p><p>Sexton studier som undersökte livskvaliteten hos dessa grupper granskades. Alla studier var baserade på självrapporteringar och var publicerade mellan 1999 och 2009.</p><p><strong>Resultat</strong></p><p>I ett flertal studier jämfördes överlevarnas mentala och fysiska hälsa med den för den friska befolkningen och resultatet visade inga skillnader mellan dessa
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6

Gisbertz, I. A. M. "Non-Hodgkin's lymphoma of the gastro-intestinal tract clinicopathological correlations /." Maastricht : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8423.

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7

Larsson, Patrik. "Standardiserat vårdförlopp – Lymfom/KLL,hur ingången påverkar utgången, vilka kriterier som ärvanligast och vilka diagnoser patienter får istället förlymfom/KLL." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91525.

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Bakgrund: Vid välgrundad misstanke om lymfom eller KLL (kronisk lymfatisk leukemi) skapatienten utredas enligt SVF (standardiserat vårdförlopp) för lymfom/KLL. Patienten måsteuppfylla minst ett av sex kriterier för att uppnå detta. SVF-programmen infördes för att kortaväntetiderna och minska regionala skillnader inom cancervården.Syfte: Att se hur ingången i SVF-utredningen (vilket kriterium patienten uppfyllde för remiss)påverkar utgången. I studien undersöks också vilka kriterier och lymfomdiagnoser som ärvanligast, vilka diagnoser patienter får istället för lymfom och hur stor andel av pati
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8

Källerwald, Susanne. "I skuggan av en hotad existens : Om den onödiga striden mellan biologi och existens i vården av patienter med malignt lymfom." Doctoral thesis, Växjö universitet, Institutionen för vårdvetenskap och socialt arbete, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1575.

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The purpose of this thesis is to describe what it is like to suffer from malignant lymphoma and to highlight the care given to these patients. A reflective lifeworld approach, founded in phenomenological philosophy, has been used. Data have been collected using interviews and have been analyzed using essence-seeking analysis. The results are founded upon three empirical studies and a philosophical excursus. The results are presented in four sections. The thesis describes how patients with malignant lymphoma live in limbo characterized by existential uncertainties, partly caused by the mortal t
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9

Källerwald, Susanne. "I skuggan av en hotad existens : om den onödiga striden mellan biologi och existens i vården av patienter med malignt lymfom /." Växjö : Växjö University Press, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1575.

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10

Baarle, Debbie van. "Viro-immunological studies on the role of Epstein-Barr virus in the development of AIDS-related non-Hodgkin's lymphoma." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/57552.

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11

Aarts, Wilhelmina Maria. "The antigen receptor in the pathogenesis of B-cell non-Hodgkin's lymphomas." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/84176.

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12

Schouten, Hendricus Constantinus. "Chromosomal abnormalities in hematological malignancies." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=5640.

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13

Kolk, Lizetta Elisabeth van der. "CD20 monoclonal antibody therapy for B-cell lymphoma." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/58282.

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14

Nilsson, Fredrik, and Mikaela Engdahl. "Skattning av biverkningar : Sjuksköterske- och patientuppfattning om behandlingsrelaterade biverkningar vid stamcellstransplantation." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143462.

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A possible treatment for patients with lymphoma and myeloma is stem cell transplantation (SCT). SCT is preceded with cytostatic treatment. There are several side effects related to this treatment, for example fatigue, nausea, constipation/diarrhoea, pain, mucositis and loss of appetite. Aim: Investigate which side effects related to the treatment where most troubling after SCT and if nurse assessment and patient assessment differ. Methods: A quantitative empirical study with repeated measuring. The two groups of nurses and patients answered a form independently. Results: Loss of appetite and f
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15

Berglund, Mattias. "Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4266.

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16

Jysky, Camilla. "Poliklinisering och dess samband med cytostatikarelaterat fördröjt illamående och kräkningar hos patienter som genomgått autolog stamcellstransplantation." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-218159.

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Introduktion Autolog stamcellstransplantation är idag en vanlig behandling vid myelom och högmaligna lymfom hos patienter &lt;65 år utan omfattande komorbiditet. Behandlingen delas upp i fem faser: induktionsbehandling, stamcellsmobilisering, stamcellsskörd, konditionering med högdoscytostatika och stamcellsåtergivning/transplantation. Initialt behandlades alla patienter som genomgick autolog stamcellstransplantation inom slutenvården under den sista behandlingsfasen, det vill säga i samband med konditionering och stamcellsåtergivning. Sedan 1990-talet har man dock på många håll i
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17

Peroja, P. (Pekka). "Oxidative stress in diffuse large B-cell lymphoma and follicular lymphoma, and TP53 mutations and translocations of MYC, Bcl-2 and Bcl-6 in diffuse large B-cell lymphoma." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526218595.

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Abstract Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are two of the most common lymphomas in the Western world. DLBCL is an aggressive disease with a good response to treatment; about 75% of patients achieve permanent remission after first-line treatment. In patients with relapses or primary refractory disease, prognosis is dismal; only 10–20% of them can be cured, even with aggressive treatments. FL is an indolent lymphoma with a very good response to treatment and slow progression. Median survival with modern treatments is over 15 years. Nevertheless, some patients hav
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18

Hohn, Michal. "Umělé imunitní systémy pro detekci spamů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2011. http://www.nusl.cz/ntk/nusl-237087.

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This work deals with creating a hybrid system based on the aggregation of artificial immune system with appropriate heuristics to make the most effective spam detection. This work describes the main principles of biological and artificial immune system and conventional techniques to detect spam including several classifiers. The developed system is tested using well known database corpuses and a comparison of the final experiments is made.
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19

Bur, H. (Hamid). "Biological prognostic and predictive markers in Hodgkin lymphoma." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219455.

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Abstract Hodgkin lymphoma (HL) is among a heterogeneous group of lymphomas. Over 80% of all patients can be cured with chemo- and radiotherapy. HL has become a model to study long-term effects of radio- and chemotherapy, because of the excellent prognosis. There are a significant number of patients who suffer or die because of the treatment-related long-term toxicity. The aim of this work was to discover new possible biological factors to predict poor prognosis and offer new aspects to individualize patient treatment in a convenient manner in HL. The retrospective study involved HL patients un
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20

Kuusisto, M. (Milla). "Translational research on challenges in the treatment of diffuse large B-cell lymphoma." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526210643.

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Abstract In the present study, some of the difficulties in the treatment of the most common malignant lymphoma, diffuse large B-cell lymphoma (DLBCL), were evaluated. Some patients develop local or central nervous system (CNS) relapse after first-line treatment. The treatment of relapsed disease is challenging and despite all efforts, some patients die of the disease. Chemoresistant disease also remains challenging because some patients suffer from refractory disease of a progressive nature. The antioxidant enzymes peroxiredoxins (Prxs) and thioredoxin-1 (Trx) were evaluated as prognostic and
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Molin, Daniel. "Bystander Cells and Prognosis in Hodgkin Lymphoma." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2547.

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<p>Hodgkin lymphoma (HL) is characterised histologically by a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells surrounded by benign cells, and clinically by a relatively good prognosis. The treatment, however, leads to a risk of serious side effects. Knowledge about the biology of the disease, particularly the interaction between the HRS cells and the surrounding cells, is essential in order to improve diagnosis and treatment. </p><p>HL patients with abundant eosinophils in the tumours have a poor prognosis, therefore the eosinophil derived protein eosinophil cationic protein (ECP)
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Mrhalová, Karolína. "Nehodgkinské lymfomy (epidemiologie, trendy a možnosti prevence)." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-278993.

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Non-Hodgkin's lymphomas as lymphoproliferative disease are among the cancer is still increasing incidence. According to the World analysis is the high incidence observed mainly in developed countries than in development, which could suggest that also applies to the modern way of life. In the Czech Republic recorded a similar trend increasing incidence. In 2002, non-Hodgkin's tumors reached the 11th place in the incidence of individual tumors in the Czech Republic. From the etiological point of view it is typically multifactorial diseases, but some of the units are associated with inducing caus
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23

Veselá, Pavla. "Nodální a extranodální lymfomy: klinickopatologická, imunohistochemická, molekulárně-biologická charakteristika." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-353549.

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3 Abstract The doctor thesis is composed of two major studies, both of them focused on the mantle cell lymphoma (MCL). The first part deals with the verification of the prognostic influence of Mantle Cell Lymphoma International Prognostic Index (MIPI) and of the proliferative activity in 235 patients with MCL diagnosed in 1996-2008 in the Czech Republic. This population study was performed in the collaboration with the Czech Lymphoma Study Group. The clinical data of patients were completed in April 2012. The diagnosis of MCL was confirmed by our central histopathologic examination of prethera
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Berková, Adéla. "Přínos molekulárně genetických a cytogenetických analýz k diagnostice a predikci léčebné odpovědi u pacientů s non-Hodgkinskými lymfomy." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338423.

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Malignant lymphoproliferative disorders include highly heterogeneous entities, i.e. lymphomas (Non-Hodgkin - NHL, as well Hodgkin's lymphoma), lymphoid leukemias, multiple myeloma and others. As currently many chromosomal aberrations with diagnostic and prognostic significance are known, molecular cytogenetic analyses of tumor cell genome has become a substantial examination also in lymphoproliferative disorders. This thesis focuses primarily on chronic lymphocytic leukemia (CLL), which is one of the mature B-cell neoplasms and represents the most common type of leukemia. We analyzed four most
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Hušková, Hana. "Zvýšená exprese mikroRNA miR-155 a snížená exprese její cílové mRNA kódující transkripční faktor PU.1 ve vzorcích tumorů z lidských lymfomů." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322036.

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Lymphomas are heterogenous class of diseases characterized by proliferation of a malignant lymphocyte clone. MicroRNA miR-155 was found to be a key molecule in immune response, namely in inflammation and germinal reaction of B cells. On the other hand, miR-155 can drive lymphoproliferation in mouse and its levels were found to be elevated in certain lymphoma types in human. MiR-155 down-regulates expression of its target gene PU.1, a hematopoietic transcription factor important for B cell differentiation. Expression of the gene encoding miR-155, known as MIR155HG, is controled by several trans
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Klánová, Magdalena. "Experimentální terapie B-nehodgkinských lymfomů." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-372609.

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1 ABSTRACT B-cell non-Hodgkin lymphomas (B-NHL) represent the most common mature lymphoproliferative diseases. B-NHL arise at different stages of B-cell development and represent their malignant counterpart. Diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) are aggressive types of B-NHLs. Deregulation of cell cycle control, inhibition of apoptosis or abnormal DNA damage response play a key role in the pathogenesis of DLBCL and MCL. Aberrant activation of several signaling pathways that further promote survival, cell proliferation or affect the tumor microenvironment have bee
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Nilsson, Madeleine. "Personers upplevelser av sjukdomen lymfom : En litteraturstudie." Thesis, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11504.

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28

Šiftancová, Jana. "Studium buněčného cyklu u maligních lymfomů řady B." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-380569.

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29

Vít, Ondřej. "Proteomická analýza rozpustných i membránových proteinů buněk lymfomu." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-356201.

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In the works presented here, we studied molecular changes associated with drug resistance in human mantle cell lymphoma (MCL) cells using proteomics. Our analyses allowed us to identify causal and/or secondary changes in protein expression associated with the development of resistance to the experimental drug TRAIL and the clinically used antimetabolites cytarabine and fludarabine. Resistance of MCL cells to the recombinant proapoptotic cytokine TRAIL was associated with downregulation of key enzymes of purine metabolism. This pathway potentially represents a molecular "weakness", which could
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Koubská, Eva. "Lymfom centrálního nervového systému v obraze magnetické rezonance." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-409599.

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Background: The aim of this study was to describe the morphological signs of the central nervous system lymphoma (CNSL) in magnetic resonance imaging (MRI). We compared morphological characteristics of primary CNSL (PCNSL) and secondary CNSL (SCNSL) and also of PCNSL and glioblastoma (GBM). Methods: We included 64 patients with PCNSL (ten of them were immunocompromised), 21 patients with SCNSL and 54 patients with GBM. The diagnosis was confirmed histologically in all patients. We evaluated morphological signs on the first MRI examination. Additionally, in patients with PCNSL, we evaluated the
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Břízová, Helena. "Lymfom z buněk pláště, genová exprese v patogenezi onemocnění." Doctoral thesis, 2010. http://www.nusl.cz/ntk/nusl-278017.

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Martinsson, Gustaf. "Primära CNS-lymfom(PCNSL); med speciell inriktning påimmunohistokemisk profil, behandlingsutfall och epidemiologi." Thesis, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210492.

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Havránek, Ondřej. "Genetické faktory u lymfoproliferativních nádorů Alterace genu CHEK2 u lymfomů a vybraných solidních tumorů." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-299547.

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Genetic factors in lymphoproliferative malignancies. Focus on CHEK2 gene in lymphomas with comparison to distinct solid tumors. MUDr. Ondřej Havránek Summary of PhD thesis: Background: The checkpoint kinase 2 gene (CHEK2) codes for an important mediator of DNA damage response pathway that among others interacts with the p53 protein. Mutations in the CHEK2 gene increase the risk of several cancer types, however, their role in non- Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) is not clear. The most frequent TP53 gene R72P polymorphism was analyzed in several studies in NHL but not in HL. Met
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Kořínková, Klára. "Role onkogenů PIM v biologii a chemoresistenci agresivních lymfómů." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397074.

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Proviral integration site for Moloney murine leukemia virus (PIM) kinases are serine/threonine kinases and oncoproteins involved in tumorigenesis of many solid and hematopoietic malignancies including mantle cell lymphoma (MCL) and diffuse-large B-cell lymphoma (DLBCL). They were shown to promote growth and survival of cancer cells by phosphorylation of proteins involved in cell cycle regulation, transcription, translation and apoptosis. Their potential as therapeutic target is, however, complicated by existence of overlapping signaling pathways. Here we show that inhibition of PIM kinases wit
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Votavová, Hana. "Odlišení primárně mediastinálního a difuzního velkobuněčného B-lymfomu s využitím metody real-time kvantitativní polymerázové řetězové reakce." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-299441.

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Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. It is a molecular and prognostic heterogeneous disease. Three main genetic subtypes are called germinal center-like DLBCL (GC-like DLBCL), non-germinal center-like DLBCL (nonGC-like DLBCL) and primary mediastinal B-cell lymphoma (PMBL). These subtypes can be reliably distinguished only with usage of gene expression profiling (GEP). The GEP method can be applied only when fresh frozen tissue is available. The method is technically difficult and expensive. Thus, it is not used routinely. Since the DLBCL subtyp
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Molinský, Jan. "Resenzitizace leukemických a lymfomových buněk k TRAILem indukované apoptóze." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-327193.

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Apoptosis serves as a natural barrier to cancer development, and the resistance to apoptosis represents one of the key capabilities acquired during tumor development or progression. Impairment of the intrinsic apoptotic pathway exemplifies one of the established mechanisms of constitutive or acquired drug resistance. As most of the currently used cytotoxic drugs initiate tumor cell death by direct or indirect triggering of the intrinsic apoptotic pathway, impairment of the intrinsic pathway is associated with therapy failure. Targeting of the death receptors, however, enables induction of apop
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Klocperk, Adam. "Adaptivní imunita u pacientů s primárními imunodeficiencemi." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-404418.

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(ENG) This thesis summarizes the results of a project dedicated to adaptive immune system of patients with partial DiGeorge syndrome caused by deletion of 22q11.2. The introduction sets the DiGeorge syndrome into a broader context of international pathophysio- clinical classification of primary immunodeficiencies and goes into detail describing its history, causes, clinical phenotype, therapeutic options and changes of the immune system. The attached manuscripts illustrate the premature aging of the T cell population, but also impaired development of B cells with low class-switched memory and
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Šinkorová, Vendula. "Vývoj metody 8-mi barevného cytometrického testování pacientů s primárním imunodeficitem." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-336884.

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Primary immunodeficiencies represent a heterogeneous group of hereditary immune system malfunctions with very variable causes and symptoms. Multiparametric flow cytometry has become an important tool in primary immunodeficiency diagnostics and research because it provides detailed information on the phenotype of individual immune cells and their proportions in circulation. We have developed a complex monoclonal antibody panel composed of five eight-color tubes which is designed for immunophenotyping of basic lymphocyte subsets and further analysis of B and T cell subpopulations. We have optimi
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Tupý, Radek. "Komplexní předoperační zobrazování nádorů mozku." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-389253.

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Title Complex preoperative brain tumor imaging Abstract The differentiation of glioblastoma, metastases and brain lymphoma using modern diagnostic imaging methods has a major impact on the strategy of further diagnostic examinations and treatment. In a group of 67 patients with glioblastoma and 31 with cerebral metastasis, the ability to differentiate them according to the evaluation of perfusion parameters changes in peritumoral white matter by T1 dynamic post-contrast magnetic resonance imaging was verified, with the positive predictive value in glioblastoma detection up to 91%. In a group o
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Matoušková, Klára. "Vliv preventivního podávání rekombinantního erytropoetinu na redukci potřeby transfúzí erytrocytů a další parametry u pacientů s Hodgkinovým lymfomem léčených intenzivní chemoterapií." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-268943.

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Lokvenc, Milan. "Přestavby genů pro imunoglobuliny a sledování minimální reziduální nemoci u B-lymfoproliferativních onemocnění." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-310536.

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Malignant lymphomas are tumors arising by clonal proliferation of lymphocytes stopped at a specific stage of differentiation. All tumor cells arising from the original clone thus share the same characteristics and that can be used in their detection. Finding a suitable molecular marker of tumor cells is an essential step not only to disease diagnosis, but also for monitoring of minimal residual disease. Minimal residual disease is defined as the subclinical disease level, which malignant cells are not detectable for conventional cytological methods during the therapy. These residual cells can
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Schreiberová, Lucie. "Vývoj techniky pro transfer genů do T-lymfocytů pomocí polyomavirových struktur a peptidu LAH4." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-435906.

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Efficient delivery of genetic material to T-lymphocytes is key in gene therapy using T-lymphocytes with chimeric antigen receptors. Current procedures require the use of potentially dangerous viral vectors or large amount of input material. The diploma thesis therefore focuses on exploring new approaches for gene transfer into T-lymphocytes: use of safe virus-like particles (VLPs) derived from mouse polyomavirus in combination with the amphipathic cationic peptide LAH4. LAH4 has the potential to increase the efficiency of DNA and viral vector transport into cells. The system which combines VLP
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43

Belada, David. "Stanovení transkriptu BCL-2/IgH u nemocných s folikulárním B-nehodgkinským lymfomem léčených chemoterapií event. v kombinaci s monoklonální protilátkou anti CD20 - rituximabem." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-293317.

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SLÁMOVÁ, Martina. "Vliv klíštěcích slin na interakce mezi spirochetami \kur{Borrelia affzelii} a myšími dendritickými buňkami." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-52281.

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Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spichochetes was studied on three different levels: phagocytosis of borrelia by DCs, production of cytokines by borrelia-activated DCs and the ablilty of DCs to activate CD4+ T cells. The effect of Ixodes ricinus saliva on each of these levels was examined. Tick saliva was shown to decrease the number of phagocosing DCs. The ability of borrelia-activated DCs to induce both proliferation and IL-2 production in specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect o
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Babošová, Oľga. "Molekulární základy klonální heterogenity hematologických onemocnění." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-393512.

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Tumor heterogeneity has been recognized for decades. The molecular mechanisms impacting clonal heterogeneity in hematological diseases, specifically myeloproliferative neoplasms (MPN) and mantle cell lymphoma, with the focus on several inherited genetic factors, inflammation, the protective mechanisms of DNA damage response (DDR) in the leukemic transformation and the treatment strategies are the focus of this thesis. Firstly, I focus on studying germline JAK2 variants and how these may influence the initiation and progression of MPN diseases, and even contribute to further genomic alterations
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Valečka, Jan. "Identifikace nového mechanismu regulace Lck zprostředkovanou její C-terminální sekvencí." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-340365.

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T-cell activation is a complex process crucial for a proper function of immune system. It has been extensively studied and its main features are well understood. However, some of the events involved in T-cell signalling are still unclear. After T-cell receptor stimulation, Src-family kinase Lck drives the initiation of signalling by tyrosine phosphorylation. Phosphorylation of several downstream targets is dependent on the redistribution of Lck to the different compartment of the plasma membrane, called lipid rafts. In lipid rafts, active Lck is juxtaposed and activates raft-resident substrate
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Lorková, Lucie. "Proteomické přístupy ke studiu nádorových onemocnění." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338123.

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Proteomics as a modern comprehensive approach to the analysis of proteomes was applied in three projects aimed at diagnosis and therapy of cancer. The aim of the first the project was to find a new diagnostic biomarker for ovarian cancer. Two different comparative proteomic approaches were used for comparative analysis of sera from patients diagnosed with ovarian cancer and from healthy age-matched women. We identified -1-antitrypsin with increased concentration in patien sera, and apolipoprotein A4 and retinol-binding protein 4 (RBP4) with significantly decreased concentration in patients. T
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Růžičková, Barbora. "Studium struktury receptoru DCL-1 pomocí hmotnostní spektrometrie." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-324111.

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DCL-1 (CD302) is a type I transmembrane C-type lectin receptor, which is expressed on monocytes, macrophages, granulocytes and dendritic cells. However, its extracellular domain lacks the amino acids motives essential for carbohydrate binding in the presence of calcium ions, suggesting that it does not have the classic binding capacity found in other C-type lectin receptors such as the mannose receptor. No exogenous or endogenous ligands have been identified yet, though. Due to internal colocalization with F-actin we can assume, that this unconventional lectin receptor plays a role not only in
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JELÍNEK, Jiří. "Vliv interferonu gama (IFN-\recke{gamma})a specifických polyklonálních protilátek na průběh experimentální perorální infekce \kur{Encephalitozoon cuniculi in vivo}." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-46628.

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The influence of interferon gamma and specific antibodies on the infection with E. cuniculi in vivo has been studied. Reconstruction of SCID mice with CD4+ T-lymphocytes from BALB/c mice and from mice with defect gene for interferon gamma was used. Effects of the treatment with mouse recombinant interferon gamma and anti-E. cuniculi sera on survival of E. cuniculi infected SCID mice were monitored. The influence of the immunization with E. cuniculi antigen on the survival of E. cuniculi infected mice with defect gene for interferon gamma was examined.
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Valatová, Pavla. "Imunotypové rozdíly v subpopulacích CD27+ B lymfocytů u zdravých kontrol a pacientů s různými imunopatologiemi." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-357873.

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The immune system will maintain the integrity of the organism from harmful non-malicious recognizes and protects the body against exo- and endogenous toxic substances and together with the nervous and endocrine system are among regulatory systems of the organism. Recently the evidence has supported the emerging concept of different B cell subpopulations to play a direct or indirect role in a pathogenesis of spectrum of disorders. However, so far the knowledge has been limited mainly in the way of how the specific differentiation stages of B lymphocytes are involved in pathogenesis of diseases
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