Academic literature on the topic 'Melanoma – Treatment – Research'

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Journal articles on the topic "Melanoma – Treatment – Research"

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Al Hmada, Youssef, Robert T. Brodell, Naji Kharouf, et al. "Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like Cells." Cancers 16, no. 2 (2024): 470. http://dx.doi.org/10.3390/cancers16020470.

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Melanoma is the third most common type of skin cancer, characterized by its heterogeneity and propensity to metastasize to distant organs. Melanoma is a heterogeneous tumor, composed of genetically divergent subpopulations, including a small fraction of melanoma-initiating cancer stem-like cells (CSCs) and many non-cancer stem cells (non-CSCs). CSCs are characterized by their unique surface proteins associated with aberrant signaling pathways with a causal or consequential relationship with tumor progression, drug resistance, and recurrence. Melanomas also harbor significant alterations in fun
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Lorenz, Anna, Mateusz Kozłowski, Sebastian Lenkiewicz, Sebastian Kwiatkowski, and Aneta Cymbaluk-Płoska. "Cutaneous Melanoma versus Vulvovaginal Melanoma—Risk Factors, Pathogenesis and Comparison of Immunotherapy Efficacy." Cancers 14, no. 20 (2022): 5123. http://dx.doi.org/10.3390/cancers14205123.

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Cutaneous melanoma is a relatively common neoplasm, with fairly well understood pathogenesis, risk factors, prognosis and therapeutic protocols. The incidence of this disease is increasing every year. The situation is different for rare malignancies such as vulvar melanomas and for the even rarer vaginal melanomas. The risk factors for vulvovaginal tumors are not fully understood. The basis of treatment in both cases is surgical resection; however, other types of treatments such as immunotherapy are available. This paper focuses on comparing the pathogenesis and risk factors associated with th
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Chacón, Matías, Yanina Pfluger, Martín Angel, Federico Waisberg, and Diego Enrico. "Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives." Cancers 12, no. 9 (2020): 2362. http://dx.doi.org/10.3390/cancers12092362.

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Malignant melanoma represents the most aggressive type of skin cancer. Modern therapies, including targeted agents and immune checkpoint inhibitors, have changed the dismal prognosis that characterized this disease. However, most evidence was obtained by studying patients with frequent subtypes of cutaneous melanoma (CM). Consequently, there is an emerging need to understand the molecular basis and treatment approaches for unusual melanoma subtypes. Even a standardized definition of infrequent or rare melanoma is not clearly established. For that reason, we reviewed this challenging topic cons
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Sun, James, Kameko M. Karasaki, and Jeffrey M. Farma. "The Use of Gene Expression Profiling and Biomarkers in Melanoma Diagnosis and Predicting Recurrence: Implications for Surveillance and Treatment." Cancers 16, no. 3 (2024): 583. http://dx.doi.org/10.3390/cancers16030583.

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Cutaneous melanoma is becoming more prevalent in the United States and has the highest mortality among cutaneous malignancies. The majority of melanomas are diagnosed at an early stage and, as such, survival is generally favorable. However, there remains prognostic uncertainty among subsets of early- and intermediate-stage melanoma patients, some of whom go on to develop advanced disease while others remain disease-free. Melanoma gene expression profiling (GEP) has evolved with the notion to help bridge this gap and identify higher- or lower-risk patients to better tailor treatment and surveil
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Huang, Yu-Yun, Tzu-Yu Hou, Wei-Kuang Yu, et al. "The Clinical Feature and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary Referral Center." Cancers 13, no. 23 (2021): 5926. http://dx.doi.org/10.3390/cancers13235926.

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Malignant melanoma can arise from melanocytes in various structures of the eye, orbit, and ocular adnexa. We reviewed the clinical features and long-term results of all subjects with histologically proved melanoma originating from any of the ocular and periocular structures in a tertiary referral center. Overall, 88 patients including 47 men were recruited. The tumor was primarily located in the uvea, followed by the conjunctiva, orbit, eyelid, and lacrimal sac. Patients with uveal melanoma were diagnosed at a relatively younger age (47.0 years), while those with orbital and eyelid melanomas w
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Song, Jung Min, Joel Daniel Marcus, Carolyn Stanek, et al. "Single center experience of dermatologic and oncologic surveillance patterns for late stage melanomas that progressed from early stage melanoma." Journal of Clinical Oncology 36, no. 7_suppl (2018): 182. http://dx.doi.org/10.1200/jco.2018.36.7_suppl.182.

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182 Background: Recent data suggests a greater proportion and greater absolute number of thin (T1) melanomas contribute to melanoma death than thicker melanomas (Whiteman et al., J Invest Dermatol 2015). NCCN guidelines for early stage melanoma, defined as stages IA-IIA, suggest at least yearly skin check and H&P, but do not specify if dermatologic and/or oncologic surveillance should be pursued. Methods: We reviewed internal and external records of 16 consecutive patients with new, non-de novo diagnoses of unresectable stage III or IV melanoma undergoing active cancer treatment, i.e. late
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Ascierto, Paolo A., John M. Kirkwood, Francesco M. Marincola, and Giuseppe Palmieri. "Melanoma: From Research to Treatment." Journal of Skin Cancer 2011 (2011): 1–2. http://dx.doi.org/10.1155/2011/710697.

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Satish, Tejus, Shaheer Khan, Matt Levin, Richard Carvajal, and Angela J. Yoon. "Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission." Journal for ImmunoTherapy of Cancer 9, no. 10 (2021): e001219. http://dx.doi.org/10.1136/jitc-2020-001219.

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Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later
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Dimitrova, Maya, and Jeffrey Weber. "Melanoma—Modern Treatment for Metastatic Melanoma." Cancer Journal 30, no. 2 (2024): 79–83. http://dx.doi.org/10.1097/ppo.0000000000000707.

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Abstract Traditional chemotherapy has been ineffective in the treatment of metastatic melanoma. Until the use of checkpoint inhibitors, patients had very limited survival. Since the original US Food and Drug Administration approval of ipilimumab over a decade ago, the armamentarium of immunotherapeutic agents has expanded to include programmed cell death protein 1 and lymphocyte activation gene 3 antibodies, requiring a nuanced approach to the selection of frontline treatments, managing patients through recurrence and progression, and determining length of therapy. Herein, we review the existi
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Sajan, Abin, Samuel Fordyce, Andrew Sideris, et al. "Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases." Diagnostics 13, no. 11 (2023): 1836. http://dx.doi.org/10.3390/diagnostics13111836.

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Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases.
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Dissertations / Theses on the topic "Melanoma – Treatment – Research"

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Rice, James C. "Brachytherapy and endoresection in the treatment of choroidal melanoma a review of patients treated in South Africa." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10758.

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Includes bibliographical references.<br>This study is a retrospective cohort analysis of patients undergoing two different treatment modalities (brachytherapy and endoresection) for medium sized choroidal melanoma. Study methods involve the collection of baseline and follow-up data from three sources: 1) A database collected by the department of Radiation Oncology at Groote Schuur Hospital; 2) Private physicians responsible for patient follow-up following brachytherapy; 3) Private physicians responsible for endoresection surgery and patient follow-up. To date there has been limited publication
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Marusak, Charles. "MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH AND TREATMENT RESISTANCE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039.

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Books on the topic "Melanoma – Treatment – Research"

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S, Agarwala Sanjiv, and Sondak Vernon K. 1957-, eds. Melanoma: Translational research and emerging therapies. Informa Healthcare, 2008.

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Rubio, Lee. Melanoma Treatment and Research. Independently Published, 2018.

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Nathanson, Larry. Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens (Cancer Treatment and Research). Springer, 1991.

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Nathanson, Larry. Malignant Melanoma: Biology, Diagnosis, and Therapy (Cancer Treatment and Research). Springer, 1988.

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Leong, Stanley P. L. Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer (Cancer Treatment and Research). Springer, 2002.

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(Editor), C. Garbe, S. Schmitz (Editor), and C. E. Orfanos (Editor), eds. Skin Cancer: Basic Science, Clinical Research and Treatment (Recent Results in Cancer Research). Springer-Verlag Telos, 1995.

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Madhu, G., Sandeep Kautish, A. Govardhan, and Avinash Sharma, eds. Emerging Computational Approaches in Telehealth and Telemedicine: A Look at The Post-COVID-19 Landscape. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150792721220101.

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This book gives an overview of innovative approaches in telehealth and telemedicine. The Goal of the content is to inform readers about recent computer applications in e-health, including Internet of Things (IoT) and Internet of Medical Things (IoMT) technology. The 9 chapters will guide readers to determine the urgency to intervene in specific medical cases, and to assess risk to healthcare workers. The focus on telehealth along with telemedicine, encompasses a broader spectrum of remote healthcare services for the reader to understand. Chapters cover the following topics: - A COVID-19 care s
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Book chapters on the topic "Melanoma – Treatment – Research"

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Koh, Howard K., Thomas H. Sinks, Alan C. Geller, Donald R. Miller, and Robert A. Lew. "Etiology of melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_1.

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Dougherty, Michael J., and Morton M. Kligerman. "Radiotherapy of melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_13.

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Weinstock, Martin A. "Epidemiology of melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_2.

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Russel, Maria C., and Keith A. Delman. "Comparative Effectiveness in Melanoma." In Cancer Treatment and Research. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-12553-4_3.

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Hyman, Leslie, M. Cristina Leske, and Anthony P. Polednak. "Epidemiology of Ocular Melanoma." In Cancer Treatment and Research. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2043-2_4.

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Harrist, Terence J., and Calvin L. Day. "Malignant Melanoma: Prognostic Factors." In Cancer Treatment and Research. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2043-2_5.

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Bines, Steven D., Jamie H. VonRoenn, Sonia M. Kheir, and John S. Coon. "Flow cytometry in melanoma." In Cancer Treatment and Research. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1751-7_9.

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Nathanson, Larry, and Shamim Jilani. "Chemotherapy of malignant melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_12.

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Albert, Lee S., and Arthur J. Sober. "Early detection of melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_3.

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Quan, Walter D. Y., and Malcolm S. Mitchell. "Immunology and immunotherapy of melanoma." In Cancer Treatment and Research. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3080-0_9.

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Conference papers on the topic "Melanoma – Treatment – Research"

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Huang, Lisa, David Rubin, Lothar Vidal, Jordan Riser, Christopher Jones, and Samantha Hiester. "Waiting for a Cure: Factors Influencing Melanoma Treatment Delays." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.195_2024.

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Melanoma, with a five-year survival rate of 94% in early-stage diagnosis, drops significantly when diagnosed at later stages, making identifying barriers to timely treatment crucial. This literature review examines factors influencing melanoma treatment wait times and their impact on patient outcomes. Elderly, male, and Medicare patients, along with those with higher Breslow thickness and severe melanoma stages, experienced longer wait times. Patients receiving intervention within 30 days had better survival rates. Lack of knowledge and misconceptions about melanoma contribute to delayed care,
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Patel, Bhumik, and Sangnya Upadhyaya. "Neoadjuvant versus Adjuvant Therapy for Stage IIIB-IIID Melanoma." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.165_2024.

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The treatment landscape for advanced stage melanoma is rapidly evolving due to advancements in our understanding of melanoma biology and the emergence of novel therapies. This necessitates a comprehensive review to guide clinicians in adopting evidence based and patient centric approaches to treat stage IIIB-IIID melanoma. A literature review was conducted to synthesize current information on the most optimal treatment available. Data available from different clinical trials found that neoadjuvant therapy was a more effective treatment compared to adjuvant therapies alone. Furthermore, neoadju
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Tang, Bill Xu, Poonam Yadav, and Rahul Anil Sheth. "Liposomal Nanoparticle Mediated Gene Modulation for the Treatment of Melanoma in the Murine Model." In Medical Students Summer in Oncology at Anderson Research (SOAR) Program. University of Texas MD Anderson, 2024. http://dx.doi.org/10.52519/00157.

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Valle, Ana Catarina, Rosangela Andrade, Marcelo Sibata, and Aloisio Carvalho. "Ultradiluted Viscum album in the Treatment of Melanoma in a Dog (Canis familiaris) – Case Report." In HRI London 2019—Cutting Edge Research in Homeopathy: Presentation Abstracts. The Faculty of Homeopathy, 2020. http://dx.doi.org/10.1055/s-0040-1702134.

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Amaral, A., J. Díaz-Martín, T. Aasen, et al. "PO-459 Unravelling endoglin as a potential therapeutic target for the treatment of uveal melanoma." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.966.

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Kecik, Tadeusz, Iwona Switka-Wieclawska, Jan Kasprzak, Alfreda Graczyk, and Antoni Pratnicki. "Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris." In Laser Technology: Fourth Symposium, edited by Wieslaw L. Wolinski and Tadeusz Kecik. SPIE, 1995. http://dx.doi.org/10.1117/12.203328.

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Simonsen, TG, JV Gaustad, and EK Rofstad. "PO-315 Intertumor heterogeneity in vascularity and response to bevacizumab treatment in artificial melanoma brain metastases." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.828.

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Thiyagarajan, Magesh. "Portable Plasma Biomedical Device for Cancer Treatment." In ASME 2011 6th Frontiers in Biomedical Devices Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/biomed2011-66030.

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This research study examined the effect of non-thermal portable atmospheric air plasma system on leukemia cancer cells. Acute monocytic leukemia cells (THP-1) were exposed to atmospheric pressure non-thermal plasma. To assess death caused by plasma exposure, cells were subjected to trypan blue exclusion assays and a kill-curve and assessment of death overtime were compiled using data from the assays. In addition to this, DNA was harvested from treated and untreated samples to determine if apoptotic ladders were present. Results have indicated that non-thermal plasma can cause cell death in THP
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Zhao, F., N. Pieper, FN Harbers, et al. "7 Evolution of cross-resistance to CD8+ T cells in the course of BRAF and MEK inhibitor treatment in BRAFV600E melanoma." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.7.

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Mota, Virgı́nia F., Jefersson A. dos Santos, and Arnaldo De A. Araújo. "FASTensor: A tensor framework for spatiotemporal description." In XXXII Conference on Graphics, Patterns and Images. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/sibgrapi.est.2019.8298.

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Spatiotemporal description is a research field with applications in various areas such as video indexing, surveillance, human-computer interfaces, among others. Big Data problems in large databases are now being treated with Deep Learning tools, however we still have room for improvement in spatiotemporal handcraft description. Moreover, we still have problems that involve small data in which data augmentation and other techniques are not valid. The main contribution of this Ph.D. Thesis 1 is the development of a framework for spatiotemporal representation using orientation tensors enabling di
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Reports on the topic "Melanoma – Treatment – Research"

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Garsa, Adam, Julie K. Jang, Sangita Baxi, et al. Radiation Therapy for Brain Metasases. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer242.

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Objective. This evidence report synthesizes the available evidence on radiation therapy for brain metastases. Data sources. We searched PubMed®, Embase®, Web of Science, Scopus, CINAHL®, clinicaltrials.gov, and published guidelines in July 2020; assessed independently submitted data; consulted with experts; and contacted authors. Review methods. The protocol was informed by Key Informants. The systematic review was supported by a Technical Expert Panel and is registered in PROSPERO (CRD42020168260). Two reviewers independently screened citations; data were abstracted by one reviewer and checke
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Smit, Amelia, Kate Dunlop, Nehal Singh, Diona Damian, Kylie Vuong, and Anne Cust. Primary prevention of skin cancer in primary care settings. The Sax Institute, 2022. http://dx.doi.org/10.57022/qpsm1481.

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Overview Skin cancer prevention is a component of the new Cancer Plan 2022–27, which guides the work of the Cancer Institute NSW. To lessen the impact of skin cancer on the community, the Cancer Institute NSW works closely with the NSW Skin Cancer Prevention Advisory Committee, comprising governmental and non-governmental organisation representatives, to develop and implement the NSW Skin Cancer Prevention Strategy. Primary Health Networks and primary care providers are seen as important stakeholders in this work. To guide improvements in skin cancer prevention and inform the development of th
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