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Dissertations / Theses on the topic 'Mesenchymal Stromal Cells – cytology'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Nie, Yingjie, and 聶瑛潔. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells ascell-therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278681.

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Fung, Kwong-lam, and 馮廣林. "Chemoresistance induced by mesenchymal stromal cells on cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205639.

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Human mesenchymal stromal cells (hMSCs) are part of bone marrow micro-environment that supports hematopoiesis. However, hMSCs also enhance tumor progression and survival when they become part of the cancer micro-environment. I aimed to investigate the interaction between hMSCs and cancer cells during chemotherapy. Firstly, I studied the interaction between hMSCs and T-lineage acute lymphoblastic leukemia (T-ALL) cells under pegylated arginase I (BCT-100) treatment. Three T-ALL cell lines were sensitive to BCT-100 but not hMSCs. Conversely, hMSCs could partly protect all T-ALL cell lines fro

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Nie, Yingjie. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells as cell-therapy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278681.

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4

Sory, David Roger Raymond. "Dynamic loading of periosteum-derived mesenchymal stromal cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59138.

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Explosive-generated waves exhibit high-energy loading profiles featured with mechanical characteristics applied over a wide range of strain rates. Recent decades have seen unprecedented occurrence of high-energy trauma associated with blast wave exposure. One such blast-specific pathology is blast-induced heterotopic ossification (bHO), which refers to ectopic bone formation due to inappropriate mesenchymal stromal cell (MSC) osteogenesis in non-skeletal tissues. Significant effort has been made into deciphering the molecular mechanisms that allow the onset of bHO, however little research has

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Ward, Lewis Stuart Corey. "Interactions of mesenchymal stromal cells with their microenvironment." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8278/.

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Mesenchymal stromal cells (MSC) suppress the inflammatory infiltrate through crosstalk with neighbouring endothelium. However, this response is lost at chronic inflammatory sites where stromal cells instead support leukocyte recruitment and upregulate expression of podoplanin. The mechanism and function by which this inflammatory phenotype is established is unknown. We hypothesise that MSC modulation of endothelium is also altered by exposure to inflammatory cytokines, and that expression of podoplanin confers an invasive phenotype, enabling the interaction of these perivascular MSC with circu

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Pasanen, I. (Ilkka). "Stromal cells of mesenchymal origin in breast cancer." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215587.

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Abstract Breast cancer, the most common cancer in women in Finland; its prognosis varies from very good to poor. During the last two decades, mesenchymal stromal cells, carcinoma-associated fibroblasts and normal fibroblasts of the breast have been investigated in the context of breast carcinomas because of their presence in the tumor microenvironment. It has been shown that the properties of the non-malignant tumor compartment possess prognostic value. The effects that these three stromal cell types have on cancer progression have been studied, but their exact mechanisms remain still largely

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Correia, Dos Reis Mónica Sofia. "Mesenchymal stromal cells : mode of action and clinical translation." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3456.

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Mesenchymal Stromal Cells (MSCs) are an extensively used cell type in clinical trials for the treatment of various diseases. In order to obtain clinically relevant numbers, MSCs need to be expanded in vitro, usually relying on the use of foetal calf serum (FCS), which is now not recommended by the regulatory authorities. In addition, the precise mechanism of action of MSCs remains unclear. The initial rationale for the therapeutic potential of MSCs was based on their engraftment and differentiation ability. It gets increasingly clear that MSCs exert their effects in a paracrine manner, by the

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Dhadda, Paramjeet Kaur. "Using mesenchymal stromal cells to improve islet transplantation outcome." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/using-mesenchymal-stromal-cells-to-improve-islet-transplantation-outcome(aef61279-a461-4023-8a23-7caceae29a1a).html.

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Pancreatic islet transplantation is an attractive treatment option for a subset of patients with Type 1 diabetes. However islet transplantation efficacy remains hampered by a number of factors, including the impaired quality of isolated islets available for transplantation and the loss of long-term islet function post transplantation. Harnessing the properties of multipotent mesenchymal stromal cells (MSCs), which can be derived from numerous clinically relevant post-natal tissues including adipose and pancreas, is currently under investigation for improving the survival of islet cells during

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Tsui, Yat-ping, and 徐軼冰. "Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197485.

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Myelin is essential for neuronal survival and maintenance of normal functions of the nervous system. Demyelinating disorders are debilitating and are often associated with failure of resident oligodendrocyte precursor cells (OPCs) to differentiate into mature, myelinating oligodendrocytes. Derivation of OPCs, from a safe source that evades ethical issues offers a solution to remyelination therapy. We therefore hypothesized that bone marrow stromal cells (BMSCs) harbour neural progenitor cells at a pre-commitment stage and that in vitro conditions can be exploited to direct differentiation of t

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Krasheninnikova, Maria Alieva. "Adipose tissue mesenchymal stromal cells as therapeutic vehicles against glioblastoma." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97086.

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Lately adipose tissue mesenchymal stem cells (hAMSCs) have emerged as cellular vehicles for therapy of solid tumors, due to their ease of isolation and manipulation, and wound/tumor homing capacity. HAMSCs have been successfully used in suicide gene therapy, employing the prodrug activating system based on Herpes simplex virus type I thymidine kinase (HSV-TK)/ganciclovir (GCV). In the current study we demonstrate an effective model of glioblastoma therapy based on the use of genetically modified hAMSCs and in vivo monitoring of tumor and therapeutic cells. Due to the capacity of photons to pa

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11

Lenz, Daniel. "Dissecting the heterogeneity of murine mesenchymal bone marrow stromal cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21017.

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Knochenmarks-Stromazellen sind in den letzten Jahren in den Fokus der Forschung gerückt. Es konnte gezeigt werden, dass sie durch Bereitstellung von Überlebenssignalen essenziell für die Erhaltung hämatopoetischer Nischen sind. Stromales Interleukin-7 (IL-7) konnte dabei für T Zellen als Überlebenssignal identifiziert werden. Gemeinsam ist allen Stromazellen die Expression des Oberflächenmarkers CD106/VCAM-1. Ein effizientes Protokoll erlaubte die qualitative wie quantitative Isolation von Stromazellen aus dem murinen Knochenmark mit anschließender ex vivo Microarray-Analyse. Die auf diese We

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Rae, Michelle C. "An investigation into the immuno-modulatory properties of mesenchymal stromal cells." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506524.

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13

Huang, Gang [Verfasser]. "Impact of mesenchymal stromal cells on streptozotocin-induced diabetic cardiomyopathy / Gang Huang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1180387996/34.

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Roberts, Samantha. "PECAM-1 expression by mesenchymal stromal cells is regulated by Notch signalling." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/pecam1-expression-by-mesenchymal-stromal-cells-is-regulated-by-notch-signalling(1259846d-df3b-43c3-8ce0-d25135ccdedd).html.

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Mesenchymal stromal cells (MSCs) reside within the perivascular niche and have been shown in vivo to facilitate vascular repair. Previous in vitro studies, have demonstrated the potential of MSCs to differentiate towards an endothelial lineage, when cultured at high cell density; but the characterisation of these cells and the mechanisms directing this important differentiation effect are ill-defined. To resemble a three-dimensional (3D) cellular environment, MSCs were cultured as spheroids and the endothelial characteristics of these cells determined. MSCs cultured as spheroids significantly

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Gaboury, Louis A. "Studies of the role of mesenchymal cells in the regulation of hemopoiesis." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28784.

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Hemopoiesis is thought to be regulated in part by specific, but as yet undefined, interactions between primitive hemopoietic cells and fixed, non-hemopoietic marrow elements collectively referred to as the stroma. Recently, a marrow culture system has been described that allows the maintenance of primitive human hemopoietic progenitor cells for many weeks in the absence of exogenously added hemopoietic growth factors. The formation of a heterogeneous adherent layer in which many stromal elements are found appears to be important to the maintenance of hemopoiesis in this system. As part of the

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Bown, Andre B. J. "The Utilization of Multipotent Mesenchymal Stromal Cell Transplantation to Improve Fascia Repair." Youngstown State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1376390936.

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17

Consentius, Christine. "Inhibition of the crosstalk between dendritic, natural killer and T cells by mesenchymal stromal/stem cells." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17694.

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Mesenchymale Stromazellen (MSC) unterstützen die endogene Geweberegeneration und sind kaum immunogen. Die Mechanismen der Immunmodulation sind kaum bekannt. Diese Arbeit untersucht, ob MSC in die Interaktion von Dendritischen Zellen (DC), Natürlichen Killer (NK) und T Zellen eingreifen, indem sie die DC-Reifung beeinflussen. Das Netzwerk ist wichtig für die Differenzierung naïver T Zellen zu Typ 1 T Helferzellen (Th1). Abhängig vom DC-Subtyp und dem Zeitpunkt des Aufeinandertreffens, beeinflussten Knochenmark-MSC (BM-MSC) die in vitro DC-Reifung verschieden. Sie inhibierten die Differenzieru

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Ordemann, Rainer, Duohui Jing, Ana-Violeta Fonseca, et al. "Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro." Ferrata Storti Foundation, 2010. https://tud.qucosa.de/id/qucosa%3A28891.

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Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and ‘stemness’ of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion. Design and Methods In the co-culture system, we defined three distinct l

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Ordemann, Rainer, Duohui Jing, Ana-Violeta Fonseca, et al. "Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-177403.

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Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and ‘stemness’ of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion. Design and Methods In the co-culture system, we defined three distinct l

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François, Moïra. "Comprehensive study of the immunomodulatory properties of bone marrow-derived mesenchymal stromal cells." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103683.

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Over the course of the last decade, mesenchymal stromal cells (MSC) have made a remarkable entry in the field of cell-based immunotherapy. In vitro, MSC were shown to modulate the immune response, either by acting as an immunosuppressant on several immune cells, or upon IFN-γ stimulation, as an antigen presenting cell (APC) for the priming of CD4+ T cells. Although a vast array of in vivo experiments in animals and humans has undeniably proven the immunological properties of MSC, the exact mechanisms by which MSC mediate their effects remain unclear. In Chapter 1, I presented a succinct review

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Amann, Elisa Maria [Verfasser]. "Immunomodulatory and regenerative effects of mesenchymal stromal cells in trauma / Elisa Maria Amann." Ulm : Universität Ulm, 2019. http://d-nb.info/1197692819/34.

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Bader, Andreas Matthäus [Verfasser]. "Molecular mechanisms of cardioprotection by cord blood mesenchymal stromal cells / Andreas Matthäus Bader." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1100387854/34.

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Espig, Sandy [Verfasser]. "Isolation and characterization of rat bone-marrow derived mesenchymal stromal cells / Sandy Espig." Ulm : Universität Ulm. Medizinische Fakultät, 2016. http://d-nb.info/1082294284/34.

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Burk, Janina, Claudia Gittel, Sandra Heller, et al. "Gene expression of tendon markers in mesenchymal stromal cells derived from different sources." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-157823.

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Background: Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the MSC source on their properties relevant to tendon regeneration. The aim of this study was to assess and compare the expression of tendon extracellular matrix proteins and tendon differentiation markers in MSC derived from different sources as well as in native tendon tissue. MS

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Badraiq, Heba Ghazi O. "Effects of maternal body weight on Wharton's Jelly mesenchymal stromal cells (pilot study)." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/effects-of-maternal-body-weight-on-whartons-jelly-mesenchymal-stromal-cells-pilot-study(dac6be9c-1f9d-4c00-88dc-2a73ec4489b4).html.

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To investigate whether the maternal metabolic environment affects the DNA methylation of mesenchymal stromal/stem cells (MSCs) from umbilical cord (UC) Wharton’s Jelly (WJ), potentially rendering them unsuitable for clinical use in multiple recipients, a pilot study was conducted on fourteen UCs obtained post partum from healthy non-obese (BMI=19-25; n=7) and obese (BMI≥30; n=7) donors receiving elective Caesarean sections. The time of first WJ-MSCs outgrowth from UC explants was similar in samples from obese and non-obese donors. However, the cells from non-obese donors proliferated faster af

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Kinoshita, Masaki. "The novel protein kinase Vlk is essential for stromal function of mesenchymal cells." Kyoto University, 2009. http://hdl.handle.net/2433/126438.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第14862号<br>医博第3377号<br>新制||医||977(附属図書館)<br>27284<br>UT51-2009-K658<br>京都大学大学院医学研究科脳統御医科学系専攻<br>(主査)教授清水章, 教授開祐司, 教授影山龍一郎<br>学位規則第4条第1項該当

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Clough, Sally. "IL7 as a marker of a subset of bone marrow mesenchymal stromal cells." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/4771/.

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The organisation of a multitude of cellular niche components, their communication via many signalling pathways and their response to physical factors, protects and regulates haematopoietic stem cell (HSC) fate in adult bone marrow. Whilst the contribution of osteoblasts, endothelial cells and perivascular cells have been examined, the role of a second stem cell population in the bone marrow; mesenchymal stem cells, is not well understood due to the lack of distinctive markers to identify them in vivo. There is therefore a requirement to determine a characteristic that allows their prospective

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Cuthbert, Richard J. "Exploiting knowledge of mesenchymal stromal cells in vivo for bone disease therapy development." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8418/.

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This thesis aims to demonstrate how understanding of the nature of MSCs in vivo can be used to guide bone disease therapy development. It first address the unpredictable MSC content of bone marrow (BM) aspirates used for therapy; then examines MSC enrichment using clinical grade immunomagnetic cell selection. Induction of osteogenesis was subsequently explored; by examining an induced membrane (IM) used for bone regeneration. Finally the potential of a janus kinase (JAK) inhibitor to block osteogenesis was assessed, by studying its effect on MSCs in vitro. Flow cytometry was used to enumerate

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Rossi, Barbara <1986&gt. "Mesenchymal Stromal Cells (MSCs) and induced Plutipotent Stem Cells (iPSCs) in Domestic Animals: Characterization and Differentiation Potential." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6795/.

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Derivation of stem cell lines from domesticated animals has been of great interest as it benefits translational medicine, clinical applications to improve human and animal health and biotechnology. The main types of stem cells studied are Embryonic Stem Cells (ESCs), induced Pluripotent Stem Cells (iPSCs) and Mesenchymal Stem/Stromal Cells (MSCs). This thesis had two main aims: (I) The isolation of bovine MSCs from amniotic fluid (AF) at different trimesters of pregnancy and their characterization to study pluripotency markers expression. Stemness markers were studied also in MSCs isolated fr

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Khalil-Khan, Alam. "Use of native Mesenchymal Stromal Cells from the knee joint towards regenerating articular cartilage." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/17060/.

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The existing technique for the use of stem cell based therapies for joint repair are based on time-consuming laboratory culture expansion protocols that are also expensive. The purpose of this thesis was to devise ways to exploit the discovery of synovial fluid mesenchymal stromal cells (MSC) towards the cost effective development of one stage cellular therapy development for knee osteoarthritis (OA). This work is based on the hypothesis that synovial fluid (SF) MSC that originate from the synovium, can be greatly increased in the joint cavity using a novel device. Secondly, it was hypothesise

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Siriwardena, Dylan. "Determination of Immunomodulatory Bioactivity Biomarkers and Mechanistic Insights in Umbilical Cord Mesenchymal Stromal Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38497.

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Detrimental immune and inflammatory responses contribute to the pathogenesis of various conditions, including Crohn’s disease, Lupus, and sepsis.1,2,3 Unfortunately, novel treatments for detrimental immune and inflammatory responses have been met with little success. Mesenchymal stromal cells (MSCs) represent a promising cellular therapy to treat immune and inflammatory disorders due to their ability to suppress the immune system. However, despite their promise, clinical trials that have employed MSC cellular therapies have produced varying and sometimes conflicting results. These discrepancie

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Haddouti, El-Mustapha [Verfasser]. "Characterization of Mesenchymal Stromal Cells for Musculoskeletal Disorders and Regenerative Medicine / El Mustapha Haddouti." Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1238687407/34.

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Limonovs, Dmitrijs. "An investigation into mesenchymal stromal cells' behaviour in 3D environment of PNIPAM-based hydrogel." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/9356/.

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Mesenchymal stromal cells (MSCs) are multipotent cells, known for the ability to differentiate into cells of bone, fat and cartilage. MSCs are commonly sourced from the bone marrow environment, where these cells reside in a 3-dimensional (3D) environment and are exposed to components of the extracellular matrix (ECM), other cells types, biochemical and mechanical stimuli. Conventional monolayer culture cannot replicate the complexity of the in vivo bone marrow environment. Therefore, a more representative MSC culture environment is required. The aim of this project was to develop a highly tuna

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Lavado, Andrea Sofia Caetano das Neves. "Porphyrinic-nanoplatforms : controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14200/.

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Reactive Oxygen Species (ROS) are known as important intracellular signaling molecules. These are also well known for their role in oxidative stress and cellular damage, leading to their involvement in several pathologies. Despite the widespread postulation of ROS mechanisms, little is actually known about the immediate response in living cells to the generation of these highly reactive compounds. The development of nanoplatforms incorporating photosensitizers would permit the generation of ROS at specific sub-cellular locations and determine the in situ cellular response. The work presented i

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Wu, Yuenv. "Altered interactions between mesenchymal stromal cells and hematopoietic stem cells from MDS and AML through expression of FAK." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1123.

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La FAK est une tyrosine kinase cytoplasmique qui régule divers processus cellulaires, dont la survie, la prolifération, la différenciation et la motilité. Bien que diverses études aient démontré l'importance du FAK dans la pathogenèse du SMD et de la LAM, le rôle de cette molécule dans le microenvironnement des tumeurs du SMD et de la LAM reste à déterminer davantage. En examinant les CSM de la moelle osseuse qui dérivent de patients atteints de SMD et de LAM, nous avons observé une augmentation continue de l'expression et de l'activation de la FAK pendant la progression du SMD vers de la LAM,

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Ueda, Minoru, Fumitaka Kikkawa, Hideharu Hibi, et al. "Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms." Thesis, Informa healthcare, 2012. http://hdl.handle.net/2237/18891.

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Ma, Ming, and 馬明. "Human mesenchymal stromal cells enhance bone marrow metastases of neuroblastoma via SDF-1 related pathways." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45790486.

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Deng, Ruixia, and 邓瑞霞. "Astragaloside IV promotes haematopoiesis and enhances cytokines release by mesenchymal stromal cells mediated immune regulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198839.

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Although tremendous efforts have been made to search for other novel growth factors in promoting marrow recovery after irradiation or chemotherapy, there have not been any efficient and safe agents discovered so far. Danggui Buxue Tang (當歸補血湯) as a traditional Chinese herbal decoction, is commonly used for replenishing blood loss in menstruating women, or enhancing erythropoiesis and immune responses in various settings. Our previous study confirmed that Danggui Buxue Tang promotes haematopoiesis and thrombopoiesis both in vitro & in vivo. Recent studies also showed that parenteral Astragalus

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Partridge, Simon William. "The influence of hydroxyapatite nanoparticles on human mesenchymal stromal cells : application in tissue engineered constructs." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3446.

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Osteoarthritis (OA) is a debilitating disease characterised by degradation of the articular cartilage and changes in the subchondral bone. Presently the gold standard treatment for OA is total joint replacement using metal, ceramic and non-degradable polymer materials. Tissue engineering using novel bioresorbable biomaterials has the potential to stimulate regeneration of bone and cartilage for early stage intervention in OA suffers. This thesis investigates the synthesis of hydroxyapatite nanoparticles (HAp) and techniques to generate poly (lactic acid) (PLA) HAp nanocomposites. The effect of

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Smith, Joseph Robert. "Methods for isolating, expanding, and characterizing umbilical cord mesenchymal stromal cells and their in vitro metabolism." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/35462.

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Master of Science in Biomedical Sciences<br>Department of Anatomy and Physiology<br>Mark L. Weiss<br>Mesenchymal stromal cells (MSCs) derived from the umbilical cord (UC-MSCs) have therapeutic applications and are studied to understand their potential uses and immunomodulatory properties. Research must identify good manufacturing process (GMP) compliant methods to isolate and expand UC-MSCs. In addition, MSCs metabolism characteristics in culture are unknown, warranting further investigation. Viability of MSCs decreases after cryopreservation, which is detrimental to clinical translation. Prev

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Campos, Ana Margarida Ferreira. "Lipidomic analysis of mesenchymal cells candidates for cell therapy." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15275.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>Mesenchymal stromal cells are adult stem cells found mostly in the bone marrow. They have immunosuppressive properties and they have been successfully applied as biological therapy in several clinical trials regarding autoimmune diseases. Despite the great number of clinical trials, MSCs’ action is not fully understand and there are no identified markers that correlate themselves with the immunomodulatory power. A lipidomic approach can solve some of these problems once lipids are one of the major cells’ components. Therefore, in this study

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Munshi, Afnan M. N. Alam. "Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39538.

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Vivas, Pradillo Daniel. "Optimisation of a Tissue Engineering Product based on Mesenchymal Stromal Cells aiming to regenerate bony tissue." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664844.

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Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the formation of a fibrotic scar. Despite its natural healing potential, bone is not always able to repair large defects, which can result in permanent bone loss and fracture non-unions. Consequently, interventions such as bone grafting are required to replace damaged or diseased bone, accounting for more than two million grafted bones in the world annually. Currently, autografts are

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Owen, Andrew Philip. "Cellular interactions underpinning the immunomodulatory action of mesenchymal stromal cells in models of liver transplant injury." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8570/.

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End stage liver disease represents a common end point for a number of disease processes, the only current treatment for which is liver transplantation, but the demand for donor organs exceeds the supply. This has led to the use of more marginal donors with an increase in the rates of complications. Mesenchymal stem/stromal cells (MSC) are a multipotent cell capable of modulating the immune system through a number of different processes and represent a potential therapy in post transplantation liver injury. In this study I describe the prospective isolation and culture expansion of murine MSC.

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Lithopoulos, Marissa Athena. "Mesenchymal Stromal Cells to Treat Lung and Brain Injury in Neonatal Models of Chronic Lung Disease." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42124.

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Targa, Laurie. "Contribution to the study of mesenchymal stromal / stem cells heterogeneity, focus on surface markers and senescence." Thesis, Université de Lorraine, 2019. https://docnum.univ-lorraine.fr/ulprive/DDOC_T_2019_0353_TARGA.pdf.

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Les Cellules Stromales / Souches Mésenchymateuses (CSM) ont un grand potentiel pour de nombreuses applications. Elles sont les cellules les plus utilisées pour les essais cliniques développant des thérapies cellulaires. L’efficacité thérapeutique des CSM est influencée par leur amplification in vitro et d’autres facteurs tels que les paramètres liés au donneur de cellules. Pour améliorer les thérapies à base de CSM, cette étude a ciblé l’étude de leur hétérogénéité grâce à leurs marqueurs de surface, qui permettent de mutualiser la caractérisation des cellules et la possibilité de trier des ce

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Franzen, Julia [Verfasser], Wolfgang Akademischer Betreuer] Wagner, and Martin [Akademischer Betreuer] [Zenke. "DNA methylation changes upon replicative senescence of mesenchymal stromal cells / Julia Franzen ; Wolfgang Wagner, Martin Zenke." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1195446381/34.

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Saverot, Scott-Eugene. "Bone Regeneration Potential of Mesenchymal Stromal Cells derived from a Clinically Relevant Rat Model of Osteoporosis." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97582.

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Falls among the elderly are a major source of injury, often leading to serious fractures, hospitalization, and death. Osteoporosis (OP) is a global problem intimately related with these fractures, characterized by reduced bone mass, increased bone fragility. There exists a high failure rate in the translation of treatments to osteoporotic populations. Mesenchymal stromal cell (MSC) transplantation as a therapeutic strategy for OP has not yet been examined in clinical trials. This may be attributed to the mixed findings of pre-clinical studies aimed at determining the efficacy of MSC therapy to

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Perko, John C. "Applying Mesenchymal Stromal Cells and Platelet-Rich Plasma on a Collagen Matrix to Improve Fascial Repair." Youngstown State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1342115316.

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Diehl, Michael W. "Prevention of Incisional Hernias Using Mesenchymal Stromal Cells and Platelet-Rich Plasma treated Collagen Matrix Tape." Youngstown State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1402572449.

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