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Journal articles on the topic 'MiR-122-5p'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Liao, Wen, Yu Ning, Hai-Jia Xu, et al. "BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head." Clinical Science 133, no. 18 (2019): 1955–75. http://dx.doi.org/10.1042/cs20181064.

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Abstract Mesenchymal stem cells (MSCs) with multipotential differentiation capacity can differentiate into bone cells under specific conditions and can be used to treat osteonecrosis (ON) of the femoral head (ONFH) through cell transplantation. The current study aims to explore the role of bone marrow (BM) MSCs (BMSCs)-derived exosomes carrying microRNA-122-5p (miR-122-5p) in ONFH rabbit models. First, rabbit models with ONFH were established. ONFH-related miRNAs were screened using the Gene Expression Omnibus (GEO) database. A gain-of-function study was performed to investigate the effect of

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Meng, Lei, Zhangming Chen, Zhe Jiang, et al. "MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN." Acta Biochimica et Biophysica Sinica 52, no. 1 (2019): 49–57. http://dx.doi.org/10.1093/abbs/gmz141.

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Abstract Gastric cancer (GC) is one of malignant tumors with high mortality and morbidity in the world. MicroRNA-122 (miR-122) acts as a tumor suppressor in a variety of cancers and has been found to be dominant in gastric adenocarcinoma. However, the specific biological function of miR-122-5p in GC is not completely clear. In this study, we found that miR-122-5p was low-expressed in GC tissues and cell lines by using qRT-PCR. Overexpression of miR-122-5p inhibited the proliferation, migration, and invasion of GC cells by using CCK-8 and transwell assays. On the contrary, downregulation of miR

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Hukowska-Szematowicz, Beata, Agata Maciejak-Jastrzębska, Małgorzata Blatkiewicz, et al. "Changes in MicroRNA Expression during Rabbit Hemorrhagic Disease Virus (RHDV) Infection." Viruses 12, no. 9 (2020): 965. http://dx.doi.org/10.3390/v12090965.

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Current knowledge on the role of microRNAs (miRNAs) in rabbit hemorrhagic disease virus (RHDV) infection and the pathogenesis of rabbit hemorrhagic disease (RHD) is still limited. RHDV replicates in the liver, causing hepatic necrosis and liver failure. MiRNAs are a class of short RNA molecules, and their expression profiles vary over the course of diseases, both in the tissue environment and in the bloodstream. This paper evaluates the expression of miRNAs in the liver tissue (ocu-miR-122-5p, ocu-miR-155-5p, and ocu-miR-16b-5p) and serum (ocu-miR-122-5p) of rabbits experimentally infected wit

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Badacz, Rafał, Paweł Kleczyński, Jacek Legutko, et al. "Expression of miR-1-3p, miR-16-5p and miR-122-5p as Possible Risk Factors of Secondary Cardiovascular Events." Biomedicines 9, no. 8 (2021): 1055. http://dx.doi.org/10.3390/biomedicines9081055.

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Ischemic event in one arterial territory increases the risk of a subsequent ischemic event. Circulating microRNAs (miRs) emerge as a potential clinical tool to assess risk of subsequent atherothrombotic events such as cardiovascular death (CVD), myocardial infarction (MI) and ischemic stroke (IS). In this prospective study, we searched for athero-specific miRs related to cardiovascular event risk in patients with symptomatic coronary, carotid lesion, or both territories involvements. The choice of particular miRs was based on database research (Pub-Med, Bethesda, MD, USA) taking into considera

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Jiao, Yigang, Li Zhang, Jun Li, Yuqi He, Xin Zhang, and Jingzhe Li. "Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1." International Journal of Biological Markers 36, no. 1 (2021): 36–46. http://dx.doi.org/10.1177/1724600821990677.

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Background: microRNAs (miRNAs) are non-coding RNAs with important roles in the progression of human cancers, including gastric cancer. Exosomes are extracellular vesicles, which could transfer numerous noncoding RNAs, such as miRNAs. Here, in our study, we intended to investigate the role of exosomal miR-122-5p in gastric cancer progression. Methods: Exosomes were isolated utilizing commercial kit or ultracentrifugation. Biomarkers of exosomes or epithelia-mesenchymal transition (EMT) were monitored by western blot. Expression levels of miR-122-5p and G-protein-coupled receptor kinase interact

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Hänninen, Mikko, Toni Jäntti, Heli Tolppanen, et al. "Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock." International Journal of Molecular Sciences 21, no. 21 (2020): 7925. http://dx.doi.org/10.3390/ijms21217925.

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Cardiogenic shock (CS) is a life-threatening emergency. New biomarkers are needed in order to detect patients at greater risk of adverse outcome. Our aim was to assess the characteristics of miR-21-5p, miR-122-5p, and miR-320a-3p in CS and evaluate the value of their expression levels in risk prediction. Circulating levels of miR-21-5p, miR-122-5p, and miR-320a-3p were measured from serial plasma samples of 179 patients during the first 5–10 days after detection of CS, derived from the CardShock study. Acute coronary syndrome was the most common cause (80%) of CS. Baseline (0 h) levels of miR-

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Salazar-Ruales, Carolina, Jessica-Viviana Arguello, Andrés López-Cortés, et al. "Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population." BioMed Research International 2018 (November 21, 2018): 1–9. http://dx.doi.org/10.1155/2018/9792730.

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary microRNAs (miRNAs) have emerged as a promising molecular tool for early diagnosis of HNSCC. The aim was to identify the differential expression of salivary miRNAs associated with HNSCC in the high altitude mestizo Ecuadorian population. Using PCR Arrays, miR-122-5p, miR-92a-3p, miR-1

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Zhi, Feng, Naiyuan Shao, Lian Xue та ін. "Characteristic MicroRNA Expression Induced by δ-Opioid Receptor Activation in the Rat Liver Under Prolonged Hypoxia". Cellular Physiology and Biochemistry 44, № 6 (2017): 2296–309. http://dx.doi.org/10.1159/000486067.

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Background/Aims: Hypoxic/ischemic injury to the liver is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ ischemic events, and δ-opioid receptor (DOR) is protective against hypoxic/ischemic injury, we asked if pharmacological activation of DOR can alter hypoxic events by regulating miRNA expression in the liver. As the first step, the present work aimed at testing the effect of DOR activation on hepatic miRNA expression in hypoxia. Methods: Male Sprague Dawley rats were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10

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Liu, Naihua, Yuancheng Huang, Fengbin Liu, and Hong Liu. "Serum exosomal miR-122-5p, GAS, and PGR in the non-invasive diagnosis of CAG." Open Medicine 16, no. 1 (2021): 1350–55. http://dx.doi.org/10.1515/med-2021-0342.

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Abstract Objective The aim of this study was to integrate the serum exosomal miRNA miR-122-5p with canonical serological biomarkers for the non-invasive screening of chronic atrophic gastritis (CAG) patients. Methods miR-122-5p and U6 were amplified by the quantitative reverse transcription polymerase chain reaction (RT-qPCR), gastrin (GAS), pepsinogen I (PG-I), and PG-II and were measured by ELISA. The area under the receiver operating characteristic (ROC) curves and their correlation were analyzed. Results In the present study, GAS level and PG-I/PG-II ratio (PGR) were increased in CAG group

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Pushkin, Anton A., Ilya A. Alliluev, Eduard E. Rostorguev, et al. "Role of miR-122-5P, miR-107, miR-22-3P, and miR-330-3P microRNAs in regulation of HIF1A expression in high-grade gliomas." Journal of Clinical Oncology 38, no. 15_suppl (2020): e14550-e14550. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14550.

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e14550 Background: HIF1-alfa is a powerful regulator of angiogenesis and cell invasion activating a wide range of oncogenes. Control of the HIF1-alpha transcription is strictly regulated by many molecular pathways, including miRNAs which can become targets for gene therapy of cancer. Methods: The study included 30 patients with histologically verified high-grade gliomas. RNAs were isolated from 30 paired (tumor and control) samples using the TRIzol reagent (Thermo Fisher, USA). The cDNA synthesis was performed using the Reverta MMLV kit (Sintol, Russia). Expression of miRNAs and HIF1A was eval

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Singh, Sandeep, Maurice W. J. de Ronde, Maayke G. M. Kok, et al. "MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability." Open Heart 7, no. 1 (2020): e001223. http://dx.doi.org/10.1136/openhrt-2019-001223.

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BackgroundIn this study, we discovered and validated candidate microRNA (miRNA) biomarkers for coronary artery disease (CAD).MethodCandidate tissue-derived miRNAs from atherosclerotic plaque material in patients with stable coronary artery disease (SCAD) (n=14) and unstable coronary artery disease (UCAD) (n=25) were discovered by qPCR-based arrays. We validated differentially expressed miRNAs, along with seven promising CAD-associated miRNAs from the literature, in the serum of two large cohorts (n=395 and n=1000) of patients with SCAD and UCAD and subclinical atherosclerosis (SubA) and contro

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Derumeaux, Geneviève A., and Thomas d’Humières. "MicroRNA, miR-122-5p, Stiffens the Diabetic Heart." JACC: Cardiovascular Imaging 14, no. 6 (2021): 1143–45. http://dx.doi.org/10.1016/j.jcmg.2021.01.025.

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Lak, Ramin, Ramin Yaghobi, and Masood Garshasbi. "Importance of miR-125a-5p and miR-122-5p expression in patients with HBV infection." Cellular and Molecular Biology 66, no. 5 (2020): 1. http://dx.doi.org/10.14715/cmb/2020.66.5.1.

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Gillet, Virginie, Annie Ouellet, Yulia Stepanov, et al. "miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus." Journal of Clinical Endocrinology & Metabolism 104, no. 11 (2019): 5157–69. http://dx.doi.org/10.1210/jc.2018-02693.

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Abstract Context Underlying mechanisms leading to gestational diabetes mellitus (GDM) are still under investigation, and it is unclear whether the placenta plays a role in triggering glucose intolerance or if its functions are modified in response to the hyperglycemia. Circulating miRNAs are involved in placental development and function and are encapsulated in extracellular vesicles (EVs). Objective To compare differential expression of miRNAs in circulating EVs in pregnancies complicated by GDM vs controls. Methods This was a case-control study nested in a prospective pregnancy cohort includ

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Lee, Seunghyun, Namki Hong, Yongnyun Kim, et al. "Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study." Diagnostics 11, no. 9 (2021): 1704. http://dx.doi.org/10.3390/diagnostics11091704.

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Primary hyperparathyroidism (PHPT) is the leading cause of secondary osteoporosis. Although bone mineral density (BMD) tends to recover after parathyroidectomy in PHPT patients, the degree of recovery varies. Circulating microRNAs (miRNAs) profiles are known to be correlated with osteoporosis and fracture. We aimed to investigate whether osteoporotic fracture-related miRNAs are associated with postoperative BMD recovery in PHPT. Here, 16 previously identified osteoporotic fracture-related miRNAs were selected. We analyzed the association between the preoperative level of each miRNA and total h

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Loria, Antonio Di, Vincenzo Dattilo, Domenico Santoro, et al. "Expression of Serum Exosomal miRNA 122 and Lipoprotein Levels in Dogs Naturally Infected by Leishmania infantum: A Preliminary Study." Animals 10, no. 1 (2020): 100. http://dx.doi.org/10.3390/ani10010100.

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Current knowledge on the role of exosomal microRNA (miRNA) in canine leishmaniasis (CL), with particular regards to the interaction between miR-122 and lipid alterations, is limited. The aim of this study was to isolate/characterize exosomes in canine serum and evaluate the expression of miR-122 in ten healthy and ten leishmaniotic dogs. Serum exosomes were isolated using a polymer-based kit, ExoQuick® and characterized by flow cytometry and transmission electron microscopy, whereas miR-122-5p expression was evaluated by quantitative reverse-transcriptase polymerase chain reaction. A significa

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Chang, Young, Jae-A. Han, Suk Min Kang, et al. "Clinical impact of serum exosomal microRNA in liver fibrosis." PLOS ONE 16, no. 9 (2021): e0255672. http://dx.doi.org/10.1371/journal.pone.0255672.

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Background/aim We investigated alterations in the expression of serum exosomal miRNAs with the progression of liver fibrosis and evaluated their clinical applicability as biomarkers. Methods This study prospectively enrolled 71 patients who underwent liver biopsy at an academic hospital in Korea. Exosomes were extracted from serum samples, followed by next-generation sequencing (NGS) of miRNAs and targeted real-time quantitative polymerase chain reaction. A model was derived to discriminate advanced fibrosis based on miRNA levels and the performance of this model was evaluated. Validation of t

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Bogusławska, Popławski, Alseekh, et al. "MicroRNA-Mediated Metabolic Reprograming in Renal Cancer." Cancers 11, no. 12 (2019): 1825. http://dx.doi.org/10.3390/cancers11121825.

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Metabolic reprogramming is one of the hallmarks of renal cell cancer (RCC). We hypothesized that altered metabolism of RCC cells results from dysregulation of microRNAs targeting metabolically relevant genes. Combined large-scale transcriptomic and metabolic analysis of RCC patients tissue samples revealed a group of microRNAs that contribute to metabolic reprogramming in RCC. miRNAs expressions correlated with their predicted target genes and with gas chromatography-mass spectrometry (GC-MS) metabolome profiles of RCC tumors. Assays performed in RCC-derived cell lines showed that miR-146a-5p

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Chantzichristos, Dimitrios, Per-Arne Svensson, Terence Garner, et al. "MiR-122-5p: A Novel Biomarker of Glucocorticoid Action." Journal of the Endocrine Society 5, Supplement_1 (2021): A89. http://dx.doi.org/10.1210/jendso/bvab048.178.

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Abstract Background: Glucocorticoids are among the most prescribed medications for various indications, and treatment with glucocorticoids is associated with increased morbidity and mortality. A biomarker allowing quantification of glucocorticoid action could improve treatment safety and efficacy. Objective: To identify and validate circulating biomarkers of glucocorticoid action using a clinical experimental study and multi-omic network analysis. Methods: In a randomized, controlled, crossover, single-blind trial, 10 subjects without endogenous glucocorticoid production (Addison’s disease) re

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Gioffré, Sonia, Mattia Chiesa, Daniela Maria Cardinale, et al. "Circulating MicroRNAs as Potential Predictors of Anthracycline-Induced Troponin Elevation in Breast Cancer Patients: Diverging Effects of Doxorubicin and Epirubicin." Journal of Clinical Medicine 9, no. 5 (2020): 1418. http://dx.doi.org/10.3390/jcm9051418.

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Anthracyclines are anti-neoplastic drugs presenting cardiotoxicity as a side effect. Cardiac troponins (cTn) and echocardiography are currently used to assess cardiac damage and dysfunction, but early biomarkers identifying patients in need of preventive treatments remain a partially met need. Circulating microRNAs (miRNAs) represent good candidates, so we investigated their possible roles as predictors of troponin elevation upon anthracycline treatment. Eighty-eight female breast cancer patients administered with doxorubicin (DOX) or epirubicin (EPI) were divided into four groups basing on dr

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Xu, Zhuo, Guangchao Liu, Meng Zhang, et al. "miR-122-5p Inhibits the Proliferation, Invasion and Growth of Bile Duct Carcinoma Cells by Targeting ALDOA." Cellular Physiology and Biochemistry 48, no. 6 (2018): 2596–606. http://dx.doi.org/10.1159/000492702.

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Background/Aims: Bile duct cancer, although not among the most common tumors, still accounts for more and more worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues and cells and explore the underlying molecular mechanism regulated by miR-122-5p, this study was designed to provide a potential molecular target in bile duct cancer treatment. Methods: Western blot and immunohistochemistry were performed to detect the ALDOA protein level in duct carcinoma tissues. The transfection efficiency was confirmed by western blot and/or RT-qPCR assay.

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Pratama, Muhammad Yogi, Devis Pascut, Sofia Tamini, et al. "Circulating microRNA Associated to Different Stages of Liver Steatosis in Prader–Willi Syndrome and Non-Syndromic Obesity." Journal of Clinical Medicine 9, no. 4 (2020): 1123. http://dx.doi.org/10.3390/jcm9041123.

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Background: Prader–Willi syndrome (PWS) is a rare and poorly characterized disease. Recent genomic and transcriptomic studies contributed to elucidate the molecular bases of the syndrome. In this study, we characterized the expression of circulating miRNAs in patients with PWS compared to those with non-syndromic obesity in association with liver steatosis. Methods: MiRNAs were studied by qRT-PCR in serum samples from 30 PWS and 30 non-syndromic obese subjects. Results: MiRNA expression was associated with the presence of the syndrome and to the grade of liver steatosis. MiR-122-5p, miR-151a,

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Ortega, Francisco José, Josep María Mercader, Victoria Catalán, et al. "Targeting the Circulating MicroRNA Signature of Obesity." Clinical Chemistry 59, no. 5 (2013): 781–92. http://dx.doi.org/10.1373/clinchem.2012.195776.

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BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and potential therapeutic targets. We sought to define the circulating pattern of miRNAs in obesity and examine changes after weight loss. METHODS We assessed the genomewide circulating miRNA profile cross-sectionally in 32 men and after surgery-induced weight loss in 6 morbidly obese patients. The most relevant miRNAs were cross-sectionally validated in 80 men and longitudinally in 22 patients (after surgery-induced weight los

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Wan, Lanlan, Zhen Su, Fayin Li, Pengfei Gao, and Xianlong Zhang. "MiR-122-5p suppresses neuropathic pain development by targeting PDK4." Neurochemical Research 46, no. 4 (2021): 957–63. http://dx.doi.org/10.1007/s11064-020-03213-w.

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Wang, Yu, Wenguang Chang, Yuan Zhang, et al. "Circulating miR-22-5p and miR-122-5p are promising novel biomarkers for diagnosis of acute myocardial infarction." Journal of Cellular Physiology 234, no. 4 (2018): 4778–86. http://dx.doi.org/10.1002/jcp.27274.

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Zhu, Maoying, Juan Lu, Jianyun Shen, Lumin Fei, and Deyu Chen. "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis." PeerJ 8 (November 3, 2020): e10147. http://dx.doi.org/10.7717/peerj.10147.

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Occludin is a structural protein of tight junctions (TJ) in the blood–testis barrier (BTB). A 22-amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown. In this study, a 22AA-induced TJ destruction animal model was constructed to investigate the effect of 22AA on Sertoli cells (SCs) and spermatid counts and cell apoptosis at different time points using a multiplex immunofluorescence technique. The effect of 22AA on the location and distribution of occludin was analyzed via dual confocal fluorescence microscope. Western blo

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Venkatesan, Nalini, Perinkulam Ravi Deepa, Vikas Khetan, and Subramanian Krishnakumar. "Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy." Bioinformatics and Biology Insights 9 (January 2015): BBI.S21742. http://dx.doi.org/10.4137/bbi.s21742.

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Purpose Retinoblastoma (RB), a primary pediatric intraocular tumor, arises from primitive retinal layers. Several novel molecular strategies are being developed for the clinical management of RB. miRNAs are known to regulate cancer-relevant biological processes. Here, the role of selected miRNAs, namely, miR-532-5p and miR-486-3p, has been analyzed for potential therapeutic targeting in RB. Methods A comprehensive bioinformatic analysis was performed to predict the posttranscriptional regulators (miRNAs) of the select panel of genes [Group 1: oncogenes (HMGA2, MYCN, SYK, FASN); Group 2: cancer

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Matamala, Nerea, María Teresa Vargas, Ricardo González-Cámpora, et al. "Tumor MicroRNA Expression Profiling Identifies Circulating MicroRNAs for Early Breast Cancer Detection." Clinical Chemistry 61, no. 8 (2015): 1098–106. http://dx.doi.org/10.1373/clinchem.2015.238691.

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Abstract BACKGROUND The identification of novel biomarkers for early breast cancer detection would be a great advance. Because of their role in tumorigenesis and stability in body fluids, microRNAs (miRNAs) are emerging as a promising diagnostic tool. Our aim was to identify miRNAs deregulated in breast tumors and evaluate the potential of circulating miRNAs in breast cancer detection. METHODS We conducted miRNA expression profiling of 1919 human miRNAs in paraffin-embedded tissue from 122 breast tumors and 11 healthy breast tissue samples. Differential expression analysis was performed, and a

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Heverhagen, Anna E., Nathalie Legrand, Vinona Wagner, Volker Fendrich, Detlef K. Bartsch, and Emily P. Slater. "Overexpression of MicroRNA miR-7-5p Is a Potential Biomarker in Neuroendocrine Neoplasms of the Small Intestine." Neuroendocrinology 106, no. 4 (2017): 312–17. http://dx.doi.org/10.1159/000480121.

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Background/Aims: Neuroendocrine neoplasms of the small intestine (SI-NENs) constitute 25-30% of all gastroenteropancreatic NEN. These tumors arise from enterochromaffin cells, and little is known about their microRNA (miRNA) expression. The purpose of this study was to characterize the expression of miRNAs in SI-NEN and to determine the potential of miRNAs as noninvasive blood-based biomarkers. Methods: miRNA was purified from 15 tumor and 7 control tissue samples, converted to cDNA, and applied to a miScript miRNA PCR. The small nucleolar RNA, SNORD95, was used as an endogenous control. Resul

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Lee, Seunghyun, Namki Hong, Kyoung Jin Kim, Jong Ju Jeong, and Yumie Rhee. "Circulating MicroRNA-23a-5p Is a Potential Biomarker for Recovery of Bone Mass After Parathyroidectomy in Primary Hyperparathyroidism." Journal of the Endocrine Society 5, Supplement_1 (2021): A258. http://dx.doi.org/10.1210/jendso/bvab048.524.

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Abstract Circulating microRNA (miRNA), a non-coding RNA molecule, is the potential biomarker for bone and mineral metabolism. Primary hyperparathyroidism (PHPT) is one of the leading causes of secondary osteoporosis. After parathyroidectomy, BMD improves as parathyroid hormone (PTH) decreases in patients with PHPT but degree of recovery in BMD vary greatly among patients. Biomarkers which are able to predict postoperative bone response may facilitate individualized approach to PHPT treatment. In this study, we aimed to investigate whether changes of miRNA related to PHPT can predict postoperat

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Ruggeri, Clarissa, Sonia Gioffré, Mattia Chiesa, et al. "A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo." Disease Markers 2018 (December 9, 2018): 1–9. http://dx.doi.org/10.1155/2018/8395651.

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Background. Cardiotoxicity is a detrimental side effect of the anticancer drug doxorubicin (DOX), characterized by progressive heart dysfunction. Circulating microRNAs (miRNAs) are recognized as potential biomarkers of cardiac disease; thus, we aimed to investigate their association with late cardiotoxicity in an animal model of disease. Methods. Twenty C57BL/6 female mice were administered with 24 mg/kg cumulative dose of DOX or saline during 2 weeks, followed by a recovery period of one month (T42). Echocardiography was performed at baseline and at T42, and plasma samples were collected at T

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Vasu, Srividya, Jiemin M. Yang, James Hodges, et al. "Circulating miRNA in Patients Undergoing Total Pancreatectomy and Islet Autotransplantation." Cell Transplantation 30 (January 1, 2021): 096368972199933. http://dx.doi.org/10.1177/0963689721999330.

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Circulating microRNAs (miRNAs) can be biomarkers for diagnosis and progression of several pathophysiological conditions. In a cohort undergoing total pancreatectomy with islet autotransplantation (TPIAT) from the multicenter Prospective Observational Study of TPIAT (POST), we investigated associations between a panel of circulating miRNAs (hsa-miR-375, hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-216a-5p, hsa-miR-320d, hsa-miR-200c, hsa-miR-125b, hsa-miR-7-5p, hsa-miR-221-3p, hsa-miR-122-5p) and patient, disease and islet-isolation characteristics. Plasma samples ( n = 139) were collected before T

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Kiss, Attila, Stefan Heber, Anne-Margarethe Kramer, et al. "MicroRNA Expression Profile Changes after Cardiopulmonary Bypass and Ischemia/Reperfusion-Injury in a Porcine Model of Cardioplegic Arrest." Diagnostics 10, no. 4 (2020): 240. http://dx.doi.org/10.3390/diagnostics10040240.

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Identification of microRNAs (miRNA) associated with cardiopulmonary bypass, cardiac arrest and subsequent myocardial ischemia/reperfusion may unravel novel therapeutic targets and biomarkers. The primary aim of the present study was to investigate the effects of cardiopulmonary bypass and temperature of cardioplegic arrest on myocardial miRNA profile in pigs’ left ventricular tissue. We employed next-generation sequencing to analyse miRNA profiles in the following groups: (1) hearts were arrested with antegrade warm St Thomas Hospital No. 2 (STH2) cardioplegia (n = 5; STH2-warm, 37 °C) and (2)

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Ahmed, Mohd Murshad, Romana Ishrat, Safia Tazyeen, et al. "In Silico Integrative Approach Revealed Key MicroRNAs and Associated Target Genes in Cardiorenal Syndrome." Bioinformatics and Biology Insights 15 (January 2021): 117793222110273. http://dx.doi.org/10.1177/11779322211027396.

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Cardiorenal syndromes constellate primary dysfunction of either heart or kidney whereby one organ dysfunction leads to the dysfunction of another. The role of several microRNAs (miRNAs) has been implicated in number of diseases, including hypertension, heart failure, and kidney diseases. Wide range of miRNAs has been identified as ideal candidate biomarkers due to their stable expression. Current study was aimed to identify crucial miRNAs and their target genes associated with cardiorenal syndrome and to explore their interaction analysis. Three differentially expressed microRNAs (DEMs), namel

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Černá, Václava, Pavel Ostašov, Pavel Pitule, Jiří Moláček, Vladislav Třeška, and Martin Pešta. "The Expression Profile of MicroRNAs in Small and Large Abdominal Aortic Aneurysms." Cardiology Research and Practice 2019 (November 29, 2019): 1–8. http://dx.doi.org/10.1155/2019/8645840.

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Background. Abdominal aortic aneurysms (AAA) are relatively frequent in elderly population, and their ruptures are related with high mortality rate. There are no actually used laboratory markers predicting the AAA development, course, and rupture. MicroRNAs are small noncoding molecules involved in posttranscriptional gene expression regulation, influencing processes on cell and tissue levels, and are actually in focus due to their potential to become diagnostic or prognostic markers in various diseases. Methods. Tissue samples of AAA patients and healthy controls were collected, from which mi

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Mansueto, Gelsomina, Giuditta Benincasa, Nunzia Della Mura, Giovanni Francesco Nicoletti, and Claudio Napoli. "Epigenetic-sensitive liquid biomarkers and personalised therapy in advanced heart failure: a focus on cell-free DNA and microRNAs." Journal of Clinical Pathology 73, no. 9 (2020): 535–43. http://dx.doi.org/10.1136/jclinpath-2019-206404.

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Dilated cardiomyopathy (DCM) represents a common genetic cause of mechanical and/or electrical dysfunction leading to heart failure (HF) onset for which truncating variants in titin (TTN) gene result in the most frequent mutations. Moreover, myocyte and endothelial cell apoptosis is a key endophenotype underlying cardiac remodelling. Therefore, a deeper knowledge about molecular networks leading to acute injury and apoptosis may reveal novel circulating biomarkers useful to better discriminate HF phenotypes, patients at risk of heart transplant as well as graft reject in order to improve perso

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Kang, Bong Kyun, In kyeom Hwang, Yoon Suk Lee, Jaihwan Kim, and Jin-Hyeok Hwang. "MicroRNA-27b as a prognostic marker in pancreatic neuroendocrine tumor." Journal of Clinical Oncology 32, no. 3_suppl (2014): 251. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.251.

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251 Background: Pancreatic neuroendocrine tumors (PNETs) are heterogeneous group of tumors with a wide spectrum of behavioral characteristics. PNET generally behaves in an indolent fashion. However, when metastasis occurs, it is difficult to be treated. Little is known about prognostic biomarker in PNET. The aim of this study was to elucidate prognostic biomarker in PNET using nanostring microRNA (miRNA) array technology. Methods: We had already selected several candidate miRNAs (miR-27b, miR-122, miR-142-5p, miR-196a, miR-223, miR-590-5p, miR-630 and miR-944), which indicated 3 folds expressi

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Lin, Jingyang, and Xiaochun Zheng. "Salvianolate Blocks Apoptosis During Myocardial Infarction by Down Regulating miR-122-5p." Current Neurovascular Research 14, no. 4 (2018): 323–29. http://dx.doi.org/10.2174/1567202614666171026114630.

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ErgÃ¼n, Sercan, Celaletdin Camci, Ebru Temiz, et al. "The relationship of miR-122-5p with trastuzumab therapy in breast cancer." Journal of Clinical Oncology 33, no. 15_suppl (2015): e11593-e11593. http://dx.doi.org/10.1200/jco.2015.33.15_suppl.e11593.

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Jiang, Meng, Weiyuan Ma, Yumei Gao, et al. "IL-22-induced miR-122-5p promotes keratinocyte proliferation by targeting Sprouty2." Experimental Dermatology 26, no. 4 (2017): 368–74. http://dx.doi.org/10.1111/exd.13270.

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Zhang, Wei, Haitao Jiang, Yunjie Chen, and Feng Ren. "Resveratrol chemosensitizes adriamycin‐resistant breast cancer cells by modulating miR‐122‐5p." Journal of Cellular Biochemistry 120, no. 9 (2019): 16283–92. http://dx.doi.org/10.1002/jcb.28910.

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El-Diwany, Ramy, Lisa N. Wasilewski, Kenneth W. Witwer, et al. "Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release." Journal of Virology 89, no. 18 (2015): 9454–64. http://dx.doi.org/10.1128/jvi.00955-15.

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ABSTRACTPlasma microRNAs (miRNAs) change in abundance in response to disease and have been associated with liver fibrosis severity in chronic hepatitis C virus (HCV) infection. However, the early dynamics of miRNA release during acute HCV infection are poorly understood. In addition, circulating miRNA signatures have been difficult to reproduce among separate populations. We studied plasma miRNA abundance during acute HCV infection to identify an miRNA signature of early infection. We measured 754 plasma miRNAs by quantitative PCR array in a discovery cohort of 22 individuals before and during

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Kim, Jae, Ji Jun, Soo Park, Seong Yang, Si Bae, and Gi Kim. "Dynamic Regulation of miRNA Expression by Functionally Enhanced Placental Mesenchymal Stem Cells Promotes Hepatic Regeneration in a Rat Model with Bile Duct Ligation." International Journal of Molecular Sciences 20, no. 21 (2019): 5299. http://dx.doi.org/10.3390/ijms20215299.

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Placenta-derived mesenchymal stem cells (PD-MSCs) were highlighted as therapeutic sources in several degenerative diseases. Recently, microRNAs(miRNAs) were found to mediate one of the therapeutic mechanisms of PD-MSCs in regenerative medicine. To enhance the therapeutic effects of PD-MSCs, we established functionally enhanced PD-MSCs with phosphatase of regenerating liver-1 overexpression (PRL-1(+)). However, the profile and functions of miRNAs induced by PRL-1(+) PD-MSCs in a rat model with hepatic failure prepared by bile duct ligation (BDL) remained unclear. Hence, the objectives of the pr

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Yuan, Wenya, Lili Liu, Lixia Liang, et al. "MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure." Gene 724 (January 2020): 144156. http://dx.doi.org/10.1016/j.gene.2019.144156.

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Favreau, Amanda, Erin Cross, and Pradeep Sathyanarayana. "Mir-590-5p, Mir-219-5p, Mir-15b and Mir-628-5p Are Commonly Regulated by IL-3, GM-CSF and G-CSF in Acute Myeloid Leukemia,." Blood 118, no. 21 (2011): 3520. http://dx.doi.org/10.1182/blood.v118.21.3520.3520.

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Abstract Abstract 3520 IL-3, GM-CSF and G-CSF are predominant regulators for growth and differentiation of myeloid progenitors. Interestingly, they all signal via a common JAK2-STAT5 pathway in myeloid progenitor compartments. However, the specific mechanism through which JAK2-STAT5 responds differentially to early-acting and lineage restricted cytokines, particularly in leukemic and stem/progenitor cells, is largely unresolved. Aberrations in IL-3, GM-CSF and G-CSF induced signaling are frequently reported in acute myeloid leukemia (AML). microRNA (miRNA) play several crucial roles during hem

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Dégano, Irene R., Anna Camps-Vilaró, Isaac Subirana, et al. "Association of Circulating microRNAs with Coronary Artery Disease and Usefulness for Reclassification of Healthy Individuals: The REGICOR Study." Journal of Clinical Medicine 9, no. 5 (2020): 1402. http://dx.doi.org/10.3390/jcm9051402.

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Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. Human endothelial and vascular smooth muscle cells were treated with oxidized/native low-density lipoproteins, and microRNA expression was analyzed. Differentially expressed and CAD-related miRNAs were examined in serum samples from (1) a case-control stud

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Bueno Marinas, Maria, Rudy Celeghin, Marco Cason, et al. "A microRNA Expression Profile as Non-Invasive Biomarker in a Large Arrhythmogenic Cardiomyopathy Cohort." International Journal of Molecular Sciences 21, no. 4 (2020): 1536. http://dx.doi.org/10.3390/ijms21041536.

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Arrhythmogenic Cardiomyopathy (AC) is a clinically and genetically heterogeneous myocardial disease. Half of AC patients harbour private desmosomal gene variants. Although microRNAs (miRNAs) have emerged as key regulator molecules in cardiovascular diseases and their involvement, correlated to phenotypic variability or to non-invasive biomarkers, has been advanced also in AC, no data are available in larger disease cohorts. Here, we propose the largest AC cohort unbiased by technical and biological factors. MiRNA profiling on nine right ventricular tissue, nine blood samples of AC patients, an

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Wang, Cheng, Cuihua Yang, Xi Chen, et al. "Altered Profile of Seminal Plasma MicroRNAs in the Molecular Diagnosis of Male Infertility." Clinical Chemistry 57, no. 12 (2011): 1722–31. http://dx.doi.org/10.1373/clinchem.2011.169714.

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BACKGROUND Although microRNAs (miRNAs) play essential roles in spermatogenesis, little is known about seminal plasma miRNAs in infertile men. We investigated the profile of seminal plasma miRNAs in infertile men to identify miRNAs that are altered in infertility; we then evaluated their diagnostic value. METHODS Seminal plasma samples were obtained from 289 infertile men and 168 age-matched fertile control individuals. The stability of the miRNAs was first assessed by time-course and freeze–thaw cycle analyses. The Solexa sequencing technology was used for an initial screen of the miRNAs in sa

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Pascut, Devis, Sofia Tamini, Silvia Bresolin, et al. "Differences in circulating microRNA signature in Prader–Willi syndrome and non-syndromic obesity." Endocrine Connections 7, no. 12 (2018): 1262–74. http://dx.doi.org/10.1530/ec-18-0329.

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Prader–Willi syndrome (PWS) represents the most common genetic-derived obesity disorder caused by the loss of expression of genes located on the paternal chromosome 15q11.2-q13. The PWS phenotype shows peculiar physical, endocrine and metabolic characteristics compared to those observed in non-syndromic essential obesity. Since miRNAs have now a well-established role in many molecular pathways, including regulatory networks related to obesity, this pilot study was aimed to characterize the expression of circulating miRNAs in PWS compared to essential obesity. The circulating miRNome of 10 PWS

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Ge, Yulong, Wenzhi Tu, Junjun Li, et al. "MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1." Toxicology and Applied Pharmacology 399 (July 2020): 115054. http://dx.doi.org/10.1016/j.taap.2020.115054.

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