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Journal articles on the topic 'MiR-17(similar to)92'

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Published: 4 June 2021

Last updated: 10 February 2022

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1

Khuu, Cuong, Tor Paaske Utheim, and Amer Sehic. "The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25." Scientifica 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1379643.

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MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers. Studies in mouse and human cells have identified the miR-17-92 cluster as a potential oncogene. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as th

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Bi, Chengfeng, Chunsun Jiang, Xiaoxing Jiang, et al. "The Mir-17∼92 Cluster Activates mTORC1 Signaling in MCL by Targeting Multiple Regulators of the LKB1/AMPK/mTOR Pathway." Blood 120, no. 21 (2012): 5118. http://dx.doi.org/10.1182/blood.v120.21.5118.5118.

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Abstract Abstract 5118 Mantle cell lymphoma (MCL) is an aggressive hematological malignancy with a median survival ranging between 3 and 5 years. Novel therapeutic strategies are urgently needed to improve the outcome. Mammalian target of rapamycin (mTOR) pathway which plays a central role in controlling cell growth, proliferation and metabolism has been shown to be deregulated in MCL. mTOR inhibitors, such as rapamycin and its analogues, have been approved for treatment of relapsed/refractory MCL. However, the molecular mechanism of mTOR activation in MCL has yet to be defined. MiRNA (miR)-17

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3

Liao, Ya-Chun, Tzu-Heng Lin, Chih-Ying Chen, Shwu-Bin Lin, and Lo-Chun Au. "The Antileukemia Activity of Natural Product HQ17(3) Is Possibly Associated with Downregulation of miR-17-92 Cluster." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/306718.

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The compound 10′(Z),13′(E),15′(E)-heptadecatrienylhydroquinone [HQ17(3)] was purified from the sap of the lacquer treeRhus succedanea. HQ17(3) has cytotoxic effect on cancer cells and can inhibit topoisomerase (topo) IIαactivity. We treated various cancer cells with different doses of HQ17(3) and found that leukemia cells were most sensitive to HQ17(3). After analysis of microRNA (miRNA) profiling, we found that treatment with HQ17(3) caused downregulation of miR-17-92 cluster in some leukemia cells. These changes partially restored the normal levels from leukemia-specific miRNA expression sig

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Cao, H., W. Yu, X. Li, et al. "A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent." Gene Therapy 23, no. 6 (2016): 527–42. http://dx.doi.org/10.1038/gt.2016.22.

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Abstract Current tools for the inhibition of microRNA (miR) function are limited to modified antisense oligonucleotides, sponges and decoy RNA molecules and none have been used to understand miR function during development. CRISPR/Cas-mediated deletion of miR sequences within the genome requires multiple chromosomal deletions to remove all functional miR family members because of duplications. Here, we report a novel plasmid-based miR inhibitor system (PMIS) that expresses a new RNA molecule, which inhibits miR family members in cells and mice. The PMIS engineered RNA optimal secondary structu

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Robertus, Jan-Lukas, Miao Wang, Geert Harms, et al. "Differences in the C13orf25 miRNA Cluster in Non-Hodgkin Lymphoma and Normal B-Cell Subtypes." Blood 110, no. 11 (2007): 3586. http://dx.doi.org/10.1182/blood.v110.11.3586.3586.

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Abstract Introduction Amplification of chromosome 13q31 is a frequent occurrence in lymphoma and solid tumors. The C13orf25 gene at 13q31.3 is the primary miRNA transcript for seven miRNAs. This specific cluster of miRNAs is sequentially related to the homologous miR-106a-92 cluster on chromosome X and the miR-106b-25 cluster on chromosome 7. The miR17-92 cluster has been shown to be over expressed in various non-Hodgkin Lymphoma (NHL). As a specific group of miRNAs which are derived from the same primary miRNA transcript, each miRNA in the cluster may be expected to show a similar expression

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He, Ming, Bo Zhang, Qianqian Yin, Meng Guo, Qian Zhao, and Guo-Qiang Chen. "MicroRNA Expression Contributes to Hypoxia-Inducible Factor-1a-Induced Differentiation of Myeloid Leukemic Cells." Blood 114, no. 22 (2009): 1007. http://dx.doi.org/10.1182/blood.v114.22.1007.1007.

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Abstract Abstract 1007 Poster Board I-29 In our previous study, we showed that the hypoxia or hypoxia-mimetic agents induces differentiation of myeloid leukemic cells. During this event, hypoxia-inducible factor-1a (HIF-1a) exerts a critical role in its transcriptional activity-independent manner. MicroRNAs (miRNAs) regulate the expression of 30% of the transcripts of human genome on a posttranscriptional level. Recent work on miRNA has shed light on the possible involvement of miRNA genes in biological processes such as cell proliferation, differentiation and hematopoiesis. To reveal the miRN

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Mosakhani, Neda, Mohamed El Missiry, Emmi Vakkila, Päivi Heikkilä, Sakari Knuutila, and Jukka Vakkila. "Low Epression of MiR-18a Distinguishes Pediatric and Adult Acute Lymphoblastic Leukemia from Each Other." Blood 126, no. 23 (2015): 4991. http://dx.doi.org/10.1182/blood.v126.23.4991.4991.

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Abstract In several adult solid cancers the presence or absence of an inflammatory microenvironment has turned out to be an important prognostic factor. Acute lymphoblastic leukemia (ALL) is seen in both adults and children but the response to chemotherapy and survival is significantly worse in adults than children. Therefore, we wanted to study whether the expression of immune system associated molecular markers would be different in adult and pediatric ALL patients at the time of diagnosis. IDO and FOXP3 were studied from paraffin embedded tissue samples by immunohistochemistry in 12 pediatr

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8

Wang, Yi, Yaohui Tian, Zonghao Li, Zhaoke Zheng, and Liangliang Zhu. "miR-92 regulates the proliferation, migration, invasion and apoptosis of glioma cells by targeting neogenin." Open Medicine 15, no. 1 (2020): 283–91. http://dx.doi.org/10.1515/med-2020-0040.

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AbstractThis study aimed to explore the pathological mechanism in regulating glioma progression. The expression of miR-92 and neogenin was evaluated by qRT-PCR and western blot. Cell viability and apoptosis were measured by MTT and flow cytometry assays, respectively. The migration and invasion abilities were examined by transwell assays. The interaction between miR-92 and neogenin was conducted by dual-luciferase reporter system. As a result, we found that the expression of miR-92 was up-regulated in glioma tissues and cell lines. Down-regulation of miR-92 inhibited glioma cell proliferation,

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Souza, Felipe C., Josiane L. Schiavinato, Antonio R. Lucena-Araujo, et al. "High Aurora Kinase and Low Dido Levels Characterizes a Sub-Group of Chronic Lymphocytic Leukemia with Chromosomal Gains and High White Blood Cell Counts: Potential Inter-Regulatory Role of E2F1 and Mir-17-92 Cluster." Blood 128, no. 22 (2016): 2029. http://dx.doi.org/10.1182/blood.v128.22.2029.2029.

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Abstract During cell cycle division Aurora kinases (AURKA and AURKB) participate in the formation and control of mitotic spindle fibers, while, protein isoforms (DIDO1, DIDO2 and DIDO3), derived by alternative splicing of the DIDO gene, assist at the junction of microtubules to kinetochores. Thus, both are relevant to cell cycle maintenance. Interestingly, overexpression (or gain of function) of AURKs or low expression (or loss of function of DIDO) are both associated with centrosomal amplification and chromosomal instability (CIN), leading to aneuploidy. Among hematological diseases with CIN

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Bouska, Alyssa, Chengfeng Bi, Waseem Lone, et al. "Comprehensive Genomic Analysis of Adult Burkitt Lymphoma Identifies the B-Cell Receptor Signaling Pathway As a Potential Therapeutic Target." Blood 128, no. 22 (2016): 4095. http://dx.doi.org/10.1182/blood.v128.22.4095.4095.

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Abstract Burkitt lymphoma (BL) is the most common non-Hodgkin lymphoma (NHL) in children. Although it accounts for only 1-5% of NHL in adults, approximately 60% of the BL cases diagnosed each year in western countries occur in patients >40 years of age. Although adult and pediatric BL cases are indistinguishable by molecular classification, pediatric patients have a significantly better outcome than adults. While translocation of MYC to the immunoglobulin heavy or light chain genes is characteristic of pediatric and adult BL, genetic differences may contribute to the superior clinical outco

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Barraclough, Jennifer Y., Mugdha V. Joglekar, Andrzej S. Januszewski, et al. "A MicroRNA Signature in Acute Coronary Syndrome Patients and Modulation by Colchicine." Journal of Cardiovascular Pharmacology and Therapeutics 25, no. 5 (2020): 444–55. http://dx.doi.org/10.1177/1074248420922793.

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Background: Circulating microRNAs (miRNAs) may play a pathogenic role in acute coronary syndromes (ACS). It is not yet known if miRNAs dysregulated in ACS are modulated by colchicine. We profiled miRNAs in plasma samples simultaneously collected from the aorta, coronary sinus, and right atrium in patients with ACS. Methods: A total of 396 of 754 miRNAs were detected by TaqMan real-time polymerase chain reaction from EDTA-plasma in a discovery cohort of 15 patients (n = 3 controls, n = 6 ACS standard therapy, n = 6 ACS standard therapy plus colchicine). Fifty-one significantly different miRNAs

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Lawrie, Charles H., Shamit Soneji, Christopher D. Cooper, and Chris Hatton. "MicroRNA Expression Profiling of Diffuse Large B-Cell Lymphoma Reveals Differences between Germinal Center-Like and Activated B Cell-Like Subtypes." Blood 106, no. 11 (2005): 3002. http://dx.doi.org/10.1182/blood.v106.11.3002.3002.

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Abstract MicroRNAs (miRNA) are a recently discovered class of short non-coding RNA molecules that negatively regulate gene expression. They have been shown to play a critical role in many biological functions. In humans about 320 miRNAs have been identified, some of which are expressed in a cell-specific and developmental stage-specific manner. Recently it has been shown that the expression profile of miRNAs can be used to subtype clinical cases (and cell lines) according to diagnosis with a greater degree of accuracy than traditional gene expression analysis. The identity of miRNAs associated

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Wang, Miao, Jan-Lukas Robertus, Lu-ping Tan, et al. "miRNA Expression Profile of B-SLL Consistent with Normal Memory B Cells:BIC/miR–155 Specific Location in Proliferation Center." Blood 110, no. 11 (2007): 2081. http://dx.doi.org/10.1182/blood.v110.11.2081.2081.

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Abstract Introduction: B cell Chronic Lymphocytic Leukemia (B-CLL) is characterized by the accumulation of nonproliferating mature-appearing lymphocytes in the blood, marrow, lymph nodes, and spleen. B-CLL behaves like leukemia and is found mostly in the blood. The expression of ZAP-70 and mutation status of the immunoglobulin heavy-chain gene (IgH) can serve as prognostic markers in B-CLL. ZAP-70 positive cases usually present with unmutated IgH genes and have a bad prognosis, whereas ZAP-70 negative cases mostly present with mutated IgH genes and have good prognosis. Gene expression studies

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Beta, Madhu, Nalini Venkatesan, Madavan Vasudevan, Umashankar Vetrivel, Vikas Khetan, and Subramanian Krishnakumar. "Identification and Insilico Analysis of Retinoblastoma Serum microRNA Profile and Gene Targets towards Prediction of Novel Serum Biomarkers." Bioinformatics and Biology Insights 7 (January 2013): BBI.S10501. http://dx.doi.org/10.4137/bbi.s10501.

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Retinoblastoma (RB) is a malignant tumor of the retina seen in children, and potential non invasive biomarkers are in need for rapid diagnosis and for prognosticating the therapy. This study was undertaken to identify the differentially expressed miRNAs in the serum of children with RB in comparison with the normal age matched serum, to analyze its concurrence with the existing RB tumor miRNA profile, to identify its novel gene targets specific to RB, and to study the expression of a few of the identified oncogenic miRNAs in the advanced stage primary RB patient's serum sample. MiRNA profiling

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15

Li, Zejuan, Roger T. Luo, Shuangli Mi, et al. "Identification of Genes Deregulated in Both Human and Murine MLLRearrangement Leukemias." Blood 112, no. 11 (2008): 3359. http://dx.doi.org/10.1182/blood.v112.11.3359.3359.

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Abstract Chromosome translocations are among the most common genetic abnormalities in human leukemia. The mixed lineage leukemia (MLL) gene was identified as a common target of chromosomal translocations associated with human acute leukemias; it is located on human chromosome 11 band q23 and on mouse chromosome 9. More than 50 different loci are rearranged in11q23 leukemias involving MLL, resulting in either acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). In general, MLL rearrangements are associated with a poor prognosis. MLL-ELL and MLL-ENL resulting from t(11;19)(q23;p13

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16

Batliner, Jasmin, Mathias Jenal, Martin F. Fey, and Mario P. Tschan. "Mir-29c and Mir-424 Are Novel Myeloid Differentiation-Associated MicroRNAs in Acute Promyelocytic Leukemia." Blood 112, no. 11 (2008): 3346. http://dx.doi.org/10.1182/blood.v112.11.3346.3346.

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Abstract MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. Recent studies showed that they are critically involved in hematopoietic differentiation and function by a coordinating multi-target repression of hematopoiesis-related genes. To identify miRNAs involved in the pathogenesis of acute promyelocytic leukemia (APL), characterized by the t(15;17) translocation, we performed TaqMan Low Density Array-based miRNA expression profiling on blast cells from an APL patient under all-trans retinoic acid (ATRA) treatment. Although

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Kudo, Masatoshi, Joong-Won Park, Shuntaro Obi, et al. "Regional differences in efficacy/safety/biomarkers in a randomised study of axitinib in 2nd line patients (pts) with advanced hepatocellular carcinoma (HCC)." Journal of Clinical Oncology 34, no. 4_suppl (2016): 329. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.329.

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329 Background: A randomised, double-blind phase II study of axitinib plus BSC [AXI] vs placebo plus BSC [PBO] was conducted in HCC pts after failure of one antiangiogenic therapy. Primary outcome was presented at ESMO 2014. No significant differences in overall survival (OS) between two arms were noted overall and in pre-specified subgroup analysis (non-Asian [nA] and Asian [A]). Interestingly, improvements favouring AXI (P < 0.01) were observed in secondary efficacy endpoints and retained among A. Methods: Exploratory efficacy/safety/biomarker analyses were performed by geographic region

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Pospisil, Vit, Heidi Mocikova, Magdalena Klanova, et al. "Oncogenic Micrornas In Cerebrospinal Fluid and Sera Reflect Therapy Efficacy and Their Reappearance Precedes Clinical Relapse In Primary and Secondary CNS Lymphoma." Blood 122, no. 21 (2013): 1777. http://dx.doi.org/10.1182/blood.v122.21.1777.1777.

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Abstract Introduction MicroRNAs (miRNAs) are single-stranded non-coding RNAs (21-25nt) that negatively regulate gene expression at post-transcriptional level by blocking translation and mRNA destabilization. Diffuse large B cell lymphomas (DLBCL) overexpress oncogenic microRNAs (including miR-17-92 and miR-155) that regulate tumor growth and spreading. Unlike longer species of RNA, microRNAs are stable and detectable in body fluids including serum/plasma and cerebrospinal fluid (CSF), however their kinetics in body fluids upon course the therapy of DLBCL has not been fully explored. Notably DL

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Girerd, Sandrine, Lucie Tosca, Olivier Herault, et al. "Superoxide Dismutase 2 (Sod2) Expression Is Highly Decreased In Chronic Myeloid Leukemia (CML): Contribution To Genetic Instability In Bcr-Abl-Expressing Leukemic Cells." Blood 122, no. 21 (2013): 3980. http://dx.doi.org/10.1182/blood.v122.21.3980.3980.

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Abstract A increased oxidative stress is one of the hallmarks of chronic myeloid leukemia (CML). Manganese Superoxide dismutase 2 (SOD2) is a key scavenger enzyme against reactive oxygen species (ROS) in eukaryotic cells, playing a crucial role in antioxidant defense but its potential implication in the CML pathophysiology is not determined. We have analyzed the expression of SOD2 at the RNA level in a large cohort of CML patients (n=49) compared to a cohort of controls with non-malignant hyperleucocytosis (n= 19). This analysis showed a major decrease of SOD2 mRNA, inversely correlated with l

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Zhan, Huichun, Wayne Yu, Hai Xu, et al. "Differential Regulation of MicroRNA Expression In Polycythemia Vera CD34+ Cells." Blood 116, no. 21 (2010): 4785. http://dx.doi.org/10.1182/blood.v116.21.4785.4785.

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Abstract Abstract 4785 Introduction: Polycythemia vera (PV) is a clonal stem cell disorder characterized by unregulated red cell, white cell and platelet production, a phenotype attributable to an activating point mutation (V617F) in JAK2, a tyrosine kinase utilized for signaling by Type 1 hematopoietic growth factor receptors. However, it is generally conceded that JAK2 V617F is not the initiating mutation in PV, nor are any of the other gene mutations, deletions and amplifications discovered to date. Deregulated gene transcription is also a feature of PV but a unified mechanism for this also

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Khalaj, Mona, Carolien Woolthuis, Wenhuo Hu, Benjamin Heath Durham, and Christopher Y. Park. "Mir-99 Regulates Normal and Leukemic Stem Cell Function." Blood 128, no. 22 (2016): 1469. http://dx.doi.org/10.1182/blood.v128.22.1469.1469.

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Abstract Acute myeloid leukemia (AML) is composed of functionally heterogeneous cells including leukemic stem cells (LSCs), which exhibit the ability to self-renew and propagate disease. It is thought that failure of common chemotherapy regimens is due to insufficient eradication of LSCs. However, the mechanisms that maintain stem cell function in the hematopoietic system are not well understood. MicroRNAs play an important role in the regulation of normal and malignant hematopoietic stem cells. Our studies showed that miR-99, a miRNA highly expressed in AML patient cell populations enriched f

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Ntoufa, Stavroula, Nikos Papakonstantinou, Benedetta Apollonio, et al. "B-Cell Anergy Underlies Indolent Clinical Behavior Of CLL Stereotyped Subset #4." Blood 122, no. 21 (2013): 4115. http://dx.doi.org/10.1182/blood.v122.21.4115.4115.

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Abstract Mounting evidence suggests that specific modalities of B-cell receptor (BcR) and Toll-like receptor (TLR) collaboration and/or regulation may exist in chronic lymphocytic leukemia (CLL), eventually impacting on the behavior of the malignant clones. CLL patients assigned to stereotyped subset #4 (mutated IGHV4-34/IGKV2-30 BcRs, SS4), the largest subset within mutated CLL, are characterized clinically by early age at diagnosis and indolent disease course and genetically by few lesions, with deletion of chromosome 13q representing the exclusive recurrent aberration. Examination of the IG

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Avigad, Smadar, Keren Shichrur, Sara Elitzur, et al. "Mir Expression Profile of Peripheral Blood Lymphocytes Predicts Relapse in Pediatric Acute Lymphoblastic Leukemia." Blood 128, no. 22 (2016): 1736. http://dx.doi.org/10.1182/blood.v128.22.1736.1736.

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Abstract Introduction: Our previous findings showed that the microRNA (miR) expression profile of miR-151, miR-1290 and miR-451 measured in bone marrow (BM) aspirations taken at diagnosis can predict risk of relapse in pediatric acute lymphoblastic leukemia (ALL) patients treated according to BFM and DCOG protocols (Avigad et al., Genes, Chromosomes & Cancer; 55:328-339, 2016). The development of a minimally invasive blood test for predicting relapse in pediatric B-ALL patients can greatly benefit patients. Therefore, the aim of this current retrospective exploratory study was to investiga

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Molloy, Timothy J., Thi T. Vu, Friedrich Stölzel, Gerhard Ehninger, and David Ma. "Mir-10a Regulates Autophagy and Cell Cycle in Normal Karyotype Acute Myeloid Leukaemia." Blood 128, no. 22 (2016): 2862. http://dx.doi.org/10.1182/blood.v128.22.2862.2862.

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Abstract Aim: Normal karyotype (NK) Acute Myeloid Leukemia (AML) accounts for approximately half of all AML cases. Almost two-thirds of these carry the Nucleophosmin 1(NPM1) gene mutation (NPM1c+). MicroRNAs (miRNA/miRs), short RNA molecules that act as post-transcriptional regulators of gene expression, have multiple roles in regulating key gene signalling networks in cancer, including in NK-AML. miR-10a is significantly overexpressed in NK-AML compared to normal bone marrow, particularly in those carrying the NPM1c+mutation in which it is expressed at levels ~20-fold higher than in NPM1 wild

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Yaghoobi, Hanif, Keivan Maghooli, Masoud Asadi-Khiavi, and Nader Jafarnia Dabanloo. "GENAVOS: A New Tool for Modelling and Analyzing Cancer Gene Regulatory Networks Using Delayed Nonlinear Variable Order Fractional System." Symmetry 13, no. 2 (2021): 295. http://dx.doi.org/10.3390/sym13020295.

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Gene regulatory networks (GRN) are one of the etiologies associated with cancer. Their dysregulation can be associated with cancer formation and asymmetric cellular functions in cancer stem cells, leading to disease persistence and resistance to treatment. Systems that model the complex dynamics of these networks along with adapting to partially known real omics data are closer to reality and may be useful to understand the mechanisms underlying neoplastic phenomena. In this paper, for the first time, modelling of GRNs is performed using delayed nonlinear variable order fractional (VOF) system

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Brook, Itzhak. "Bacterial Flora of Stethoscopes' Earpieces and Otitis Externa." Annals of Otology, Rhinology & Laryngology 106, no. 9 (1997): 751–52. http://dx.doi.org/10.1177/000348949710600907.

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External otitis caused by Staphylococcus aureus was observed in a nurse after extensive use of a stethoscope. The infection recurred and a similar organism was isolated from the stethoscope's earpiece. The infection did not recur after the earpiece was cleansed after each use. In a prospective study, the bacterial flora of 35 earpieces was evaluated. Fifty-three isolates, 36 aerobic or facultative and 17 anaerobic, were recovered. The number of organisms per earpiece ranged from 14 to 204 (average 92 ± 17). The predominant isolates were Staphylococcus epidermidis (16 isolates), Propionibacteri

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Dyck, G. W., and D. J. A. Cole. "The effect of restricted energy and nutrient intake after mating on reproductive performance of multiparous sows." Animal Science 42, no. 1 (1986): 127–32. http://dx.doi.org/10.1017/s0003356100017815.

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ABSTRACTNinety-six multiparous sows were allocated at random on the 1st day of mating at the post-weaning oestrus to three dietary treatments of: 1·84 kg control diet (C); 0·92 kg control diet plus 0·92 kg pelleted hay (R); or 1·84 kg pelleted hay per day (M) for the following 10-day period to determine if restriction of nutrient intake affected reproductive performance. Subsequent to the 10-day period of nutrient intake restriction, all sows were fed 1·84 kg control diet once daily. The treatments had no effect on pregnancy rate, number of piglets born, number born alive, number weaned, or on

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Li, Yulin, Stephanie C. Casey, Peter S. Choi, and Dean W. Felsher. "miR-17–92 explainsMYConcogene addiction." Molecular & Cellular Oncology 1, no. 4 (2014): e970092. http://dx.doi.org/10.4161/23723548.2014.970092.

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Kuhnert, Frank, and Calvin J. Kuo. "miR-17-92 angiogenesis micromanagement." Blood 115, no. 23 (2010): 4631–32. http://dx.doi.org/10.1182/blood-2010-03-276428.

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Oliveira, Rudolf K. F., Mariana Faria-Urbina, Bradley A. Maron, Mario Santos, Aaron B. Waxman, and David M. Systrom. "Functional impact of exercise pulmonary hypertension in patients with borderline resting pulmonary arterial pressure." Pulmonary Circulation 7, no. 3 (2017): 654–65. http://dx.doi.org/10.1177/2045893217709025.

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Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study, we sought to evaluate the prevalence and functional impact of exercise pulmonary hypertension (ePH) across a spectrum of resting mPAP’s in consecutive patients with contemporary resting right heart catheterization (RHC) and invasive cardiopulmonary exercise testing. Patients with resting mPAP <

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Ducrocq, Guillaume P., Thomas J. Hureau, Olivier Meste, and Grégory M. Blain. "Similar Cardioventilatory but Greater Neuromuscular Stimuli With Interval Drop Jump Than With Interval Running." International Journal of Sports Physiology and Performance 15, no. 3 (2020): 330–39. http://dx.doi.org/10.1123/ijspp.2019-0031.

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Context: Drop jumps and high-intensity interval running are relevant training methods to improve explosiveness and endurance performance, respectively. Combined training effects might, however, be achieved by performing interval drop jumping. Purpose: To determine the acute effects of interval drop jumping on oxygen uptake ()—index of cardioventilatory/oxidative stimulation level and peripheral fatigue—a limiting factor of explosiveness. Methods: Thirteen participants performed three 11-minute interval training sessions during which they ran 15 seconds at 120% of the velocity that elicited max

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Hadzic, Admir, Harold S. Minkowitz, Timothy I. Melson, et al. "Liposome Bupivacaine Femoral Nerve Block for Postsurgical Analgesia after Total Knee Arthroplasty." Anesthesiology 124, no. 6 (2016): 1372–83. http://dx.doi.org/10.1097/aln.0000000000001117.

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Abstract Background The authors evaluated the efficacy of liposome bupivacaine in a femoral nerve block (FNB) after total knee arthroplasty. Methods Part 1: subjects received FNB with 20 ml liposome bupivacaine (67, 133, or 266 mg) or placebo. Part 2: subjects were randomized to FNB with liposome bupivacaine 266 mg or placebo. The primary outcome measure was area under the curve of the numeric rating scale score for pain intensity at rest through 72 h (AUC NRS-R0–72) with imputed scores after rescue medication. Results In part 1, FNB with liposome bupivacaine 266 mg (n = 24) resulted in analge

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Fiala, Mark A., David Schwab, Ravi Vij, Amanda F. Cashen, Keith Stockerl-Goldstein, and Camille N. Abboud. "A Randomized Trial of Tbo-Filgrastim Versus Filgrastim for Autologous Stem Cell Mobilization in Patients with Multiple Myeloma or Non-Hodgkin Lymphoma." Blood 126, no. 23 (2015): 516. http://dx.doi.org/10.1182/blood.v126.23.516.516.

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Abstract Background: Tbo-filgrastim, biosimilar to filgrastim, was approved by the FDA in 2012 as a new drug due to the lack of a biosimilar approval pathway at time of submission. Like filgrastim, tbo-filgrastim is currently indicated for the treatment of neutropenia following chemotherapy; however, filgrastim is also indicated for mobilization of hematopoietic progenitor cells for autologous stem cell transplantation (ASCT) while tbo-filgrastim is not. In Europe, tbo-filgrastim carries all the indications that filgrastim does, however, no prospective studies have been completed comparing tbo

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Walker, Alison R., Klaus H. Metzeler, Susan Geyer, et al. "Impact of DNMT3A mutations on Clinical Response to the Hypomethylating Agent Decitabine in Older Patients (pts) with Acute Myeloid Leukemia (AML)." Blood 118, no. 21 (2011): 944. http://dx.doi.org/10.1182/blood.v118.21.944.944.

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Abstract Abstract 944 Loss of function mutations of the DNA methyltransferase 3A (DNMT3A) gene have been associated with a negative impact on outcome in AML pts treated with conventional chemotherapy and/or stem cell transplantation. DNA methyltransferases (DNMTs) such as DNMT3A are responsible for catalyzing the addition of methyl groups to CpG dinucleotides. In AML, aberrant DNMT activity plays a role in epigenetic silencing of genes involved in hematopoiesis, and inhibition of DNMT activity by hypomethylating agents such as azacitidine and decitabine has been explored as a way to reverse hy

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Agrawal, Samir G., Christina Lim, and Ivor Cavill. "Prospective Targeted Epoietin beta Therapy for Chemotherapy-Associated Anaemia Achieves High Response Rates." Blood 106, no. 11 (2005): 588. http://dx.doi.org/10.1182/blood.v106.11.588.588.

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Abstract Background: EPO for management of chemotherapy-associated anaemia in patients with cancer is recommended by international guidelines. However, the variable response rate to EPO limits its effective deployment. In the UK, a ‘predictive factor testing service (PFTS)’ (supported by Roche) ascribes a low, moderate or high probability of response to EPO therapy - based on a two step holostic evaluation: (i) the state of erythropoiesis (serum EPO in relation to Haemoglobin concentration [Hb]; reticulocyte count and %); (ii) the need for IV iron to support erythropoiesis (MCH, reticulocyte H

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Patt, Debra A., Eileen Fonseca, Bongin Yoo, Thomas Wilson, Hans-Peter Goertz, and Catherine Lai. "Real-world treatment patterns and outcomes in HER2 positive MBC patients with brain metastasis in the U.S. community oncology setting." Journal of Clinical Oncology 34, no. 7_suppl (2016): 92. http://dx.doi.org/10.1200/jco.2016.34.7_suppl.92.

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92 Background: Patients (pts) with HER2 positive (HER2+) metastatic breast cancer (MBC) have different patterns of disease and treatment (tx) from HER2 negative MBC. Brain metastasis (BM) frequently occurs and txs vary. Methods: This retrospective study included adult HER2+ MBC pts from a community oncology network electronic health record (EHR) database and diagnosed between 2009-2011, with follow-up until 11/2014. Pts with other primary tumors were excluded. Two cohorts were defined: pts diagnosed with BM and pts with no evidence of BM (NBM), and were initially matched on age and performance

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Ko, YounJin, and TaeYong Yoo. "Development and validation of knowledge hiding motivation scale." Korean Journal of Industrial and Organizational Psychology 33, no. 1 (2020): 61–92. http://dx.doi.org/10.24230/kjiop.v33i1.61-92.

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The purpose of this study was to develop and validate knowledge hiding motivation scale. First, in preliminary study, using the open-ended survey research method, 89 cases were collected from 200 employees who were working in a variety of organizations in Korea. After eliminating overlapped and unintended cases of knowledge hiding, 42 cases in five categories(rationalization, ownership, competition, avoidance, and relation) were obtained. Based on the previous theory, we removed one category(rationalization) and constructed 34 items from cases. Then, we conducted an exploratory factor analysis

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Zhu, Hanqing, Chang Han, and Tong Wu. "MiR-17-92 cluster promotes hepatocarcinogenesis." Carcinogenesis 36, no. 10 (2015): 1213–22. http://dx.doi.org/10.1093/carcin/bgv112.

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Kuo, George, Chao-Yi Wu, and Huang-Yu Yang. "MiR-17-92 cluster and immunity." Journal of the Formosan Medical Association 118, no. 1 (2019): 2–6. http://dx.doi.org/10.1016/j.jfma.2018.04.013.

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Luley, Kim B., Shauni B. Biedermann, Axel Künstner, et al. "A Comprehensive Molecular Characterization of the Pancreatic Neuroendocrine Tumor Cell Lines BON-1 and QGP-1." Cancers 12, no. 3 (2020): 691. http://dx.doi.org/10.3390/cancers12030691.

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Experimental models of neuroendocrine tumor disease are scarce, with only a few existing neuroendocrine tumor cell lines of pancreatic origin (panNET). Their molecular characterization has so far focused on the neuroendocrine phenotype and cancer-related mutations, while a transcription-based assessment of their developmental origin and malignant potential is lacking. In this study, we performed immunoblotting and qPCR analysis of neuroendocrine, epithelial, developmental endocrine-related genes as well as next-generation sequencing (NGS) analysis of microRNAs (miRs) on three panNET cell lines

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Forconi, Francesco, Francesco Zaja, Tamara Intermesoli, et al. "Equivalent Efficacy and Lower Toxicity of Subcutaneous Cladribine at Reduced Doses (Five versus Seven Consecutive days) in Hairy Cell Leukemia: An Interim Analysis of the ICGHCL 2004 Protocol by the Italian Cooperative Group on Hcl." Blood 112, no. 11 (2008): 3174. http://dx.doi.org/10.1182/blood.v112.11.3174.3174.

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Abstract Hairy cell leukemia (HCL) is a rare B-cell neoplasm generally responsive to Cladribine. Cladribine is generally administered intravenously either as a continuous weekly infusion or as a 2-hour daily or weekly infusion for 7 days. Subcutaneous Cladribine is an alternative route with 100% bioavailability and with efficacy similar to intravenous 2CdA at the dose of 0.7 mg/kg/cycle. In indolent non-Hodgkin lymphomas other than HCL, reduction to 0.5 mg/kg/cycle determined equivalent efficacy and lower toxicity. In a national multicentre clinical trial (protocol EudraCT code: ICGHCL 2004),

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Gruson, Berengere, Sarah Ivanoff, Céline Berthon, et al. "Rural but Not Urban AML Exhibit Cytogenetic and Molecular Characteristics of Therapy-Related AML." Blood 124, no. 21 (2014): 2353. http://dx.doi.org/10.1182/blood.v124.21.2353.2353.

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Abstract Background:There are few established risk factors for AML. Benzene, radiation, prior chemotherapy treatments for cancer, and cigarette smoking have been causally linked with AML. Few studies have shown that incidence rates are highest in the agricultural region and it has been hypothesized that farming and its related exposures (e.g., pesticides) may account for this increased risk. Nonetheless, there are no do data regarding clinical, cytogenetic and molecular differences between rural and urban area. The primary objective of this study is to look for cytogenetic features of rural pa

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Kongkam, Pradermchai, Theerapat Orprayoon, Chaloemphon Boonmee, et al. "ERCP plus endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage for malignant hilar biliary obstruction: a multicenter observational open-label study." Endoscopy 53, no. 01 (2020): 55–62. http://dx.doi.org/10.1055/a-1195-8197.

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Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) may not provide complete biliary drainage in patients with Bismuth III/IV malignant hilar biliary obstruction (MHBO). Complete biliary drainage is accomplished by adding percutaneous transhepatic biliary drainage (PTBD). We prospectively compared recurrent biliary obstruction (RBO) rates between combined ERCP and endoscopic ultrasound-guided biliary drainage (EUS-BD) vs. bilateral PTBD. Methods Patients with MHBO undergoing endoscopic procedures (group A) were compared with those undergoing bilateral PTBD (group B). The

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Rice, G. E. "Biophysical characteristics of oxytocin secretory granules isolated from ovine corpora lutea." Journal of Endocrinology 116, no. 2 (1988): 267–72. http://dx.doi.org/10.1677/joe.0.1160267.

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ABSTRACT Luteal oxytocin-containing secretory granules have been isolated and characterized in terms of their physicochemical parameters. The isopynic sedimentation density (1·03 ±0·003 g/ml) and sedimentation coefficient (1670 S, 0·32 mol sucrose/l, 4 °C) of these granules have been estimated. Based upon these estimates, the average vesicle diameter (258 ± 17 nm) and vesicle weight (9·92 ±0·67 fg/vesicle) were calculated. The exchangeable water content (58·2%) of these granules was determined using density gradients prepared with deuterium oxide. Luteal oxytocin-containing granules displayed

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Childs, Bradley J., Marcia L. Scudder, Donald C. Craig, and Harold A. Goodwin. "Structural and Electronic Properties of the Iron(II) and Nickel(II) Bis(ligand) Complexes of 6-(5-Methyl-1,2,4-oxadiazol-3-yl)-2,2′-bipyridine— a Terpyridine-Based Tridentate." Australian Journal of Chemistry 52, no. 7 (1999): 673. http://dx.doi.org/10.1071/ch98153.

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Iron(II) and nickel(II) bis(ligand) complexes of 6-(5-methyl-1,2,4-oxadiazol-3-yl)-2,2′-bipyridine (L) are described. The ligand field in the iron complex is close to that at the singlet ( 1 A1) ? quintet ( 5 T2) crossover and magnetic and Mössbauer spectral evidence indicates that a spin transition occurs in salts of the iron complex but is centred above room temperature. The structures of [FeL2] [CF3SO3]2.CH3CN and [NiL2] [BF4]2.CH3CN were determined and both are very similar to the structures of the corresponding terpyridine complexes. Spectroscopic data indicate that for the iron complex π

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Osweiler, Gary D., P. F. Ross, T. M. Wilson, et al. "Characterization of an Epizootic of Pulmonary Edema in Swine Associated with Fumonisin in Corn Screenings." Journal of Veterinary Diagnostic Investigation 4, no. 1 (1992): 53–59. http://dx.doi.org/10.1177/104063879200400112.

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In 1989, corn screenings were associated with acute interstitial pulmonary edema, hydrothorax, and death in swine. Attack rate was 5–50%, case fatality rate was 50–90%, and clinical course was 1–2 days. Screenings from farms with pigs affected with pulmonary edema contained 20–330 μg fumonisin B1 per gram. Screenings containing 92 μg fumonisin B1 per gram fed to weanling pigs caused pulmonary edema and death. Sterilized corn inoculated with Fusarium moniliforme and diluted 1:1 with clean corn contained fumonisin B, (17 μg/g) and caused acute pulmonary edema when fed for 5 days. Survivors devel

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Zhu, Hanqing, Chang Han, Dongdong Lu, and Tong Wu. "miR-17-92 Cluster Promotes Cholangiocarcinoma Growth." American Journal of Pathology 184, no. 10 (2014): 2828–39. http://dx.doi.org/10.1016/j.ajpath.2014.06.024.

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Huh, Hyub, Doo Yeon Go, Jang Eun Cho, Jihoon Park, Jiwon Lee, and Hyun-Chang Kim. "Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study." Journal of International Medical Research 49, no. 2 (2021): 030006052096123. http://dx.doi.org/10.1177/0300060520961237.

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Objective General anaesthesia with tracheal intubation results in sore throat. We evaluated the influence of the two-handed jaw thrust on postoperative sore throat in patients who require tracheal intubation. Methods In this prospective, double-blind, single-centre, parallel-arm, and randomised trial, 92 patients who were scheduled for general anaesthesia for total hip arthroplasty were allocated to one of two groups. In the jaw thrust group (n = 46), the two-handed jaw thrust manoeuvre was applied at intubation. In the control group (n = 46), conventional intubation with sham jaw thrust was p

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Pospisil, Vit, Karin Vargova, Juraj Kokavec, et al. "The Oncogenic Mir-17-92 MicroRNA Cluster Is Inhibited by EGR2 During Macrophage Differentiation Via JARID1b-Mediated Histone 3 Lysine 4 Demethylation." Blood 116, no. 21 (2010): 390. http://dx.doi.org/10.1182/blood.v116.21.390.390.

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Abstract Abstract 390 The miR-17-92 cluster (Oncomir1) encodes seven related microRNAs associated with cell proliferation, apoptosis and development and is overexpressed in number of malignancies including myeloid leukemias. The miR-17-92 cluster is highly expressed in myeloid progenitors, while it becomes downregulated upon the onset of macrophage differentiation. Conversely, sustained expression of miR-17-92 is associated with a differentiation blockade (Fontana 2007). Here we report a novel mechanism of the regulation of miR-17-92 cluster within differentiating myeloid progenitors. During m

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Olive, V., M. J. Bennett, J. C. Walker, et al. "miR-19 is a key oncogenic component of mir-17-92." Genes & Development 23, no. 24 (2009): 2839–49. http://dx.doi.org/10.1101/gad.1861409.

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