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Dissertations / Theses on the topic 'Model buňky'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Orlová, Lucie. "Výpočtové modelování mechanických zkoušek živočišné buňky." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443747.

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Předkládaná diplomová práce se zabývá stavbou živých živočišných buněk a jejich odezvou na mechanické zatěžování. Zobecněným zaměřením práce je popis mechanického chování buňky nejenom ve fyziologickém, ale i v patologickém stavu. Výchozím předpokladem pro úspěšné řešení zadané úlohy je vysoce interdisciplinární přístup kombinující výpočtové přístupy mechaniky těles (v~tomto případě metodu konečných prvků) s lékařským výzkumem. Nejdůležitějším bodem při tvorbě výpočtového modelu, pomocí něhož je možné aproximovat chování živé buňky při zatížení, je zejména identifikace mechanicky významných ko

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Hoplíček, Štěpán. "Návrh robotické buňky pro manipulační operace." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-382118.

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This Master´s thesis deals with the design of a robotic cell for manipulation operations. By two robots are performed manipulation operations with a product between turntable, station with a pulsed fiber laser, label printer with applicator and conveyor belt. Further, the thesis describes the selection process of each device of the robotic cell, the design of an end effector and a fixture. The robotic cell is designed in compliance with the safety standards. The aim of this thesis is to design the robotic cell, which meets the requirement for a given cycle time. The cycle time is determined us

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Závodský, Martin. "Návrh robotické buňky pro výrobu plošných dílů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443246.

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This master’s thesis deals with the design of a robotic cell for the automation of woodworking machine tending. The task of the robot is to manipulate with the specified laminated chipboards of various sizes, before and after machining. The boards are brought to the cell on pallets in three possible placement variants. After a brief research part, conceptual designs of cell layout were created. The optimal and further elaborated design came as a result of selected evaluation criteria. The next part of the thesis consists of designs and selection processes of individual components. These were l

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Srdošová, Michaela. "Návrh robotické buňky pro manipulační operace." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400982.

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This Master`s thesis deals automation of the workplace for manipulation operations. Robot’s role is take cooler from case, insert them into the dimensional and tightness device and then robot must place cooler on the output conveyor in robotic cell. The thesis describe deployment working cell, the selection and design process of each device and the robotic cell is designed with the safety standards. On the end in this thesis is a technical-economics evaluation. The simulation model in Process Simulate is a aim of this thesis, because we know working cycle time from this model.

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Krbálek, Jaroslav. "Určování elastických parametrů pro modely izolovaných buněk." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229369.

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This diploma thesis focuses on computational modeling of the cell mechanical tests. The goal of this thesis is to build a cell model and to simulate compression test on this model. If necessary, the model should be adjusted so the model reflects real cell behavior. It was created the cell model reflecting cytoplasm, nucleus, membrane and cell cytoskeleton. Cytoskeleton was modeled as tensegrity structure. After this, the pressure test was simulated on this model. The behavior of the cell model and real cell was compared using the stress force. The stress force - cell deformation curve was mark

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Bauer, David. "Využití tensegritních struktur pro modelování mechanického chování hladkých svalových buněk." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229836.

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The master’s thesis deals with the computational modelling of the mechanical testing of isolated smooth muscle cells. The main aims are to create computational model of a cell, to simulate single-axis tensile test and to modify the model so that the model reflects real mechanical response. The model of the cell includes cytoplasm, nucleus, cell membrane and cytoskeleton which is modelled as a tensegrite structure. On this model the tensile test was simulated in case of the cell with cytoskeleton and the cell with distributed the cytoskeleton. Force-elongation curves, which were obtained from t

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Mrkva, Tomáš. "Simulační studie výrobní linky s průmyslovými roboty." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417546.

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This diploma thesis deals with the design of a robotic workplace for deburring of a given part. The robot's task is to remove the machined part from the production machine, create a blank workpiece ready for machining, and finally deburr the the machined part. There are several proposals for the layout of the robotic cell, as well as the design of the end effector, the input tray for semi-finished products and a stand with tools for deburring. Subsequently, a simulation model of the designed robotic cell is created in the Siemens Process Simulate software. Using RSC modules, the exact resultin

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8

Hupka, Dušan. "Techniky "level of detail" v knihovně OpenSceneGraph." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2014. http://www.nusl.cz/ntk/nusl-236099.

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Present graphic requires a lot of optimizations of rendering techniques and mathematical calculations. It is caused by increased requirements of scene's visualization. One of scene's optimizing techniques is the Level of detail. This thesis is focused on methods used by LOD in OpenSceneGraph and OpenGL library. Next it will be described how to choose the right level of detail in a scene. Later it will be explained how to simplify 3D models. These techniques will be implemented in converting tool and demonstrating application. Methods for simplify 3D models will be tested for their speed and qu

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Šmídová, Zlata. "Optimalizační modely v odpadovém hospodářství." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400460.

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The master’s thesis deals with the application of optimization models in the waste management. The analysis of the current state, the estimation of information about the flow of a specific waste, the estimation of the probable processing site and the method of processing is developed by a suitable approach based on sophisticated mathematical methods. The mathematical model, which was created by merging the two already existing models, brings results suitable also for forecasting the state of the waste management. The output is a comprehensive computational tool that was tested on data from the

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Abreu, Claudilene Lima de. "Avaliação da cinética de trânsito gastrintestinal de volumosos utilizando diferentes modelos matemáticos e indicadores em bovinos." Universidade Federal de Viçosa, 2008. http://locus.ufv.br/handle/123456789/5762.

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Made available in DSpace on 2015-03-26T13:55:15Z (GMT). No. of bitstreams: 1 texto completo.pdf: 793112 bytes, checksum: d869c3853a7619f4cc816a4c2ba6dcca (MD5) Previous issue date: 2008-07-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The objective of this research was to assess the kinetics of gastrointestinal transit of bulky using different mathematical models and indicators in cattle. It was used four Flemish-Zebu steers, fistulated in the rumen, distributed in experimental design 4 x 4 Latin square, and kept in confinement in individual stalls receiving daily 1 kg

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Klozar, Lukáš. "Lokalizační systém kombinující výhody GPS a GSM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218628.

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Aim of this master´s project is to analyse localization possibilities in GSM and GPS wireless networks. Choise of proper module and design location device for both GPS and GSM networks. Design and construction of system, which is able to designate it´s positron, using both GPS and GSM networks. The location informations, are send to Internet server, using GPRS system. Localization techniques in both wireless network are described. The system which is able to get position information was designed and constructed. The module´s driving software and the software, which process the localization inf

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12

Kljajič, Marko. "Simulační studie robotické linky pro obsluhu obráběcího stroje a realizaci dokončovacích operací." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417547.

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The aim of the thesis is conceptual design of robotic workplace with its subsequent simulation. The current workplace for manufacturing and deburring parts for automotive industry is operated manually. The plan is overall automation and replacement of operators by robots. The thesis deals with the concept of layout of elements in the cell, and the procedure of their selection or design. Process simulation is performed in the Process Simulate software from Siemens. For the purposes of the work is used RCS module, which on the basis of dynamic conditions can calculate the cycle of production ver

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Tobolová, Marie. "Mikrostimulátor." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219499.

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The theoretical part of the thesis deals with the explanation of the actions that occur during the stimulation of tissues with the electric current. A significant analogy with electrical circuits is used to describe the phenomena at the molecular and cellular level. The models of membrane and cell are necessary for understanding the behaviour of more complex structures, such as tissues and organs. A considerable attention is paid to the conditions of electrical stimulation which bring about response in the stimulated area. Next, the cumulative effect of the subthreshold stimulation is analysed

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Šulák, Petr. "Vysokovýklopná lopata dřevní štěpky." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-442820.

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15

Popelková, Vendula. "RAW 264.7 buňky jako protizánětlivý model: Optimalizace podmínek buněčných kultur a LPS koncentrací." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-279017.

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16

Obrtlíková, Petra. "Diferenciace lidských embryonálních kmenových buněk v buňky endotelové a hladké svalové jako model cévního vývoje." Doctoral thesis, 2010. http://www.nusl.cz/ntk/nusl-299557.

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Aims of the study: We hypothesized that the optimal source of cell for vascular regeneration will be the progenitor cells derived from human embryonic stem cells (ESCs) which can differentiate both into endothelial cells (ECs) as well as vascular smooth muscle cells (SMCs). We propose to test if the population of human ESCs, H9 cell line, can serve this role. Material and methods: Human ESCs were cocultured with stromal cells S17, M2-10B4 or Wnt1 expressing M2-10B4 cell line to generate a CD34+ cell population. After that, CD34+ cells were sorted and cultured in media containing specific cytok

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17

Hvolková, Simona. "Testování cytotoxicity na 2D a 3D modelu lidských jaterních buněk." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370986.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Simona Hvolková Supervisor: PharmDr. Jana Ramos Mandíková, Ph.D. Title of diploma thesis: Cytotoxicity testing on 2D and 3D model of human liver cells. An inherent part of drug development are in vitro assays, which might be helpful in prediction of drug toxicity. Nowadays, the majority of assays use simple 2D structures for cell growth, but 3D structures with similar conditions to in vivo are becoming more popular. The goal of the study was to assess the cytotoxicity of selected xenobio

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Svobodová, Eliška. "Příprava prasečích indukovaných pluripotentních kmenových buněk - model Huntingtonovy choroby." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323620.

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Stable porcine ES cell lines have not been succesfully established yet. Ability to selfrenew or to differentiate has been limited in different porcine ES-like cell lines so far. PiPSCs represent an alternative to pESCs. PiPSCs can be generated by reprogramming of somatic cells by introduction of several transcription factors on viral vectors and were established by several groups. However, the majority of piPS cell lines depend on transgene expression because of incomplete reprogramming and weak activation of endogenous pluripotency genes. Transgene expression can infuence differentiation pote

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Růna, Vochozková Petra. "Prasečí modely pro Huntingtonovu chorobu." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-451136.

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The causative role of the huntingtin (HTT) gene in Huntington's disease (HD) has been identified more than 25 years ago. The extension of CAG repeat stretch over 39 repeats in exon 1 of one HTT allele results in full penetrance of this neurodegenerative disorder. While the identification of the causative mutation raised hopes that development of the therapeutic compound will be easily achievable, the patients and their families are still waiting for treatment until now. The main reason for that might be the complex cellular function HTT that makes the determination of the pathologic mechanism

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Gajdoš, Roman. "Vliv imunosuprese na buněčnou terapii u myšího modelu Alzheimerovy choroby." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-410749.

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Alzheimer's disease is a chronic, progressive, neurodegenerative disease. It belongs to the most common type of dementia and worldwide it is statistically the fifth cause of mortality. The most common morphological markers are insoluble β amyloid plaques, hyperphosforylated tau proteins and formation of neurofibrilar tangles. Among the manifestations of the disease is amyloid angiopathy, synaptic transmission disorders and subsequent apoptosis, deterioration of cognitive functions and brain atrophy. Studies have shown that administration of mesenchymal stem cells (MSC) has an immunomodulatory

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Jančová, Pavlína. "Vliv sekretomu mezenchymálních kmenových buněk izolovaných z Whartonova rosolu na terapii poranění míchy u potkanů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-416124.

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As previously shown, transplantation of Wharton's jelly-derived mesenchymal stem cells in the experimental model of spinal cord injury leads to the motor and sensory functions improvement, supports neuroregeneration, angiogenesis and provides immunomodulation. On the other hand, these cells have limited migration and survival capacity, and their therapeutic effect is mediated mostly by their secretome. Therefore, application of mesenchymal stem cells derived conditioned medium is studied as an alternative option for cell therapy. In this thesis, therapeutic effect of repeated intrathecal deliv

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Pačes, Jan. "Charakterizace distribuce a dynamiky antigen-prezentujících buněk na modelu MHC II-EGFP knock-in myši." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-348328.

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Results of recent studies indicate that dendritic cells are capable of transporting commensal intestinal bacteria into the mammary glands, which ultimately leads to their occurrence in breast milk. We have therefore decided to evaluate the phenotype of immunologically relevant antigen presenting cells (APCs) present in the mammary glands and the small intestine, respectively and perform a comparison study. We also studied plasticity of these populations during lactation. In situ immunodetection and flow cytometry methods were used to determine phenotype. We succeeded in optimising the methods

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Měšťák, Ondřej. "Užití biologických materiálů k náhradě tkání v plastické chirurgii." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-326221.

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Užití biologických materiálů k náhradě tkání v plastické chirurgii ! Abstrakt v angličtině Background: Biological meshes are biomaterials consisted of extracellular matrix and used in surgery particularly for hernia treatment or thoracic wall reconstruction. They are capable of vascularization, that decreases risk of infection, expecially when used in contaminated fields. This study compared the strength of incorporation and biocompatibility of two porcine-derived grafts (cross-linked and non-cross-linked) in a rat hernia model. In addition, we hypothesized that combination of extracellular ma

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Presová, Gabriela. "Příprava a charakterizace buněčných modelů lysosomálních dědičných onemocnění - mukopolysacharidos." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-415870.

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Mucopolysaccharidoses are a group of diseases that belong to lysosomal storage disorders. A common sign of these monogenic multisystem diseases is a gene mutation leading to a deficiency of the lysosomal enzyme participating in glycosaminoglycan degradation. It results to their accumulation in the tissues and organs, where they cause a progressive damage. There is no efficient treatment available for most mucopolysaccharidoses. Moreover, the research is complicated because of the low prevalence and type of affected tissues. Animal models of these human diseases are used for an evaluation of ne

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Pytlík, Robert. "Lidské multipotentní mezenchymové stromální buňky - kostní diferenciace a podpora krvetvorby." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-372372.

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Human mesenchymal stromal cells (hMSC) are adult stem or progenitor cells, which physiological role is reparation of damaged tissues. This is achieved mostly by secretion of trophic, angiopoietic and immunomodulatory factors. Beside this, hMSC have potential to differentiate in vitro into specialized cells, especially of the mesodermal lineages. Human MSC also significantly support hematopoiesis in hematopoietic niche. This knowledge raised high hopes for therapeutic use of hMSC, especially in regenerative medicine and treatment of autoimmune diseases, including graft versus host disease (GvHD

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Zadražil, Zdeněk. "Charakterizace imunitního systém s využitím MHC II/ EGFP knock-in myši." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-304812.

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The immune system is essential for keeping the integrity of multicellular organisms. We were able to make a step forward in studying the complex immune reactions in mammals in vivo and/ or in situ using the major histocompatibility complex (MHC) class II/ enhanced green fluorescent protein (EGFP) knock-in mouse model. Due to the EGFP visualization of MHC II expressing cells we were able to observe antigen presenting cells, which are essential for the onset of immune responses, in their natural environment. Thus, we report some original features of the immune system. We have identified MHC II+

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CAISOVÁ, Veronika. "Studium nádorové imunoterapie založené na instalaci ligandů fagocytárních receptorů na nádorové buňky a objasnění probíhajících procesorů." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-370739.

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Immunotherapy became a very promising approach for cancer therapy. Tumor cells are eliminated using the body's own immune system with minimal negative effect on healthy tissue. This thesis is focused on immunotherapy based on activation of innate immunity, specifically on intratumoral application of ligands stimulating phagocytosis and Toll-like receptor ligands. This therapeutic approach was tested in several types of tumor mouse models, such as melanoma B16-F10, pancreatic adenocarcinoma, and pheochromocytoma. The composition of the therapeutic mixture as well as the application schedule wer

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BYTYUTSKYY, Dmytro. "Vztahy mezi úrovní ploidie, velikostí genomu a velikostí buňky v sérii modelů ryb ploidní úrovně od 2n do 14n." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-175340.

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The ploidy level of diploid and induced triploid tench, Tinca tinca, was verified using flow cytometry to determine relative DNA content of 4',6-diamidino-2-phenylindole (DAPI)-stained erythrocyte nuclei. The C-value (haploid nuclear DNA content; pgDNA.nucleus-1) of these same individuals was determined by means of Feulgen image analysis densitometry, in comparison to the chicken standard (Gallus gallus domesticus; 1.25 pgDNA.nucleus-1, P < 0.05), using three different approaches. Highly similar mean C-values were obtained, thus confirming the possibility of using tench blood as standard in Eu

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Hájková, Michaela. "Terapeutický potenciál mezenchymálních kmenových buněk v myším experimentálním modelu." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-368805.

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Due to their immunomodulatory and regenerative potential, mesenchymal stem cells (MSCs) represent a promising therapeutic tool for cell-based therapy, organ transplantation or tissue engineering. To improve clinical applicability of MSCs, new methods to increase their delivery and efficacy have been tested in the latest years but the mechanism of observed alterations has not yet been described. In the present project we focused on studying the effect of several factors that can significantly affect the therapeutic success of MSC-based treatment. Initially, we analysed the therapeutic effect of

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Jabůrek, Filip. "Studium vlivu mezenchymálních kmenových buněk v kombinaci s imunosupresivní terapií na zánětlivou odpověď v in vivo modelu." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-405402.

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Immunosuppressive drugs have been used for many years for the treatment of autoimmune diseases and post-transplantation treatment. While these drugs have a lot of advantages, they also show several undesirable side effects. The most common side effects are higher blood pressure, lowered renal function and susceptibility to infections. Therefore, in recent years there has been a demand for other medical approaches that do not exhibit the above-mentioned adverse effects. Among one of the newly tested approaches is the application of mesenchymal stem cells (MSCs), which possess several advantages

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Rybová, Jitka. "Patobiochemie lysosomálních střádavých onemocnění: studie Fabryho nemoci a příprava buněčných modelů X-vázaných chorob." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-388707.

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Human autopsy or biopsy tissue samples, mouse models and cell cultures of various types represent the most common materials in the investigation of cell pathogenesis of inherited diseases. This dissertation is devoted to all these approaches in the study of two X-linked lysosomal storage diseases, Fabry disease (FD,α-galactosidase A (AGAL) deficiency) and mucopolysaccharidosis type II (MPSII, idunorate-2- sulfatase (IDS) deficiency). The primary goal of the work was analysis of lipid blood group B antigens with terminal α-galactose (B-GSL) in the pancreas of FD patients with blood group B (FD-

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Faltýsková, Helena. "Experimentální modely přenosu kmenových buněk pro léčebné účely." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-297762.

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Experimental models of a transfer of stem cells for therapeutic purposes Abstract Stem cell therapy currently represents a standard procedure of treating a wide variety of hereditary diseases and serious injuries. Development of the most suitable way of transfer of stem cells into the patient body remains very important question concerning this type of therapy. In our experiments we used nanofiber scaffolds for stem cell cultivation and their subsequent transfer. These nanofibers were prepared by the original needleless electrospun NanospiderTM technology. Allogeneic cornea or skin graft were

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Žlabová, Anna. "Charakterizace vedlejší populace buněčné linie TRAMP-C2, myšího modelu karcinomu prostaty"." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-305775.

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Side population is a minor subpopulation (SP) of some cell lines, exporting staining dye Hoechst 33342 out of their cytoplasm. It is discussed as a possible source of "cancer stem cells", "tumour initiating cells" or "metastasis initiating cells". However, broad literature suggest, that stemness and other privileged properties of SP are very variable between different cell types, cell lines and stage of disease. Cell lines TRAMP are the only widely available murine models for testing of prostate cancer therapy. We noticed in literature a mention about existence of 1-2% of cells constituting si

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Knížková, Karolina. "Studium maternálně-fetálního mikrochimérismu APC s využitím MHCII/EGFP myšího modelu a clearovacích histologických technik." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-416119.

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Microchimerism arises from the exchange of cells between genetically distinct individuals. The coexistence of genetically distinct cell populations within a single organism has possible effects on health and functioning of individuals immune systems, but the exact mechanisms of action are often not yet known. With the development of microscopic technologies and software for data analysis, the possibilities of detection and phenotyping of these rare cell populations are expanding. My intention in this work is to find maternal microchimerism in embryonic tissues (E13) and intestines of breastfed

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Bednář, Vojtěch. "Počítačové modelování vývoje tkání." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-370544.

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Title: Computer Modeling of Tissue Development Author: Vojtěch Bednář Department: Department of applied mathematics Supervisor: Doc. RNDr. Zdeněk Hedrlín, CSc. Abstract: This thesis describes hybrid individual cell-based approach to modeling of systems of biological cells. In the first part reaction-diffusion model of environment is introduced together with vax equilibrium and model of a cell based on zygotic graph and cummulative states. Further, simulations modeling three biologically motivated situations are introduced: Lumen formation, tumor growth, and cellular migration in chronic inflam

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Tejklová, Tereza. "Vliv bezlepkové diety na populace imunitních buněk na NOD myším modelu diabetu 1. typu." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436129.

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Type 1 diabetes (T1D) is an autoimmune disease leading to destruction of insulin-secreting pancreatic -cells. Environmental factors e.g. exposures to infections, dietary components play a substantial role in etiopathogenesis of T1D and are responsible for rapid increase of T1D incidence in past decades, preferentially in developed countries. Despite long record of T1D research no causative cure or efficient prevention exists. While gluten displays proinflammatory properties, gluten-free diet (GFD) has been documented by several studies as a strong diabetes- preventive environmental factor in

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LEVÁ, Jana. "Imunomodulační účinky extraktů z helminta na střevní buněčnou linii potkaního modelu." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-394528.

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In this study, we examined the immunomodulatory effect of excretory/secretory products, crude adult extracts and crude larvae extracts from Hymenolepis diminuta on the intestinal epithelilal cell line from a rat. For determination of the immunomodulation effect of all H. diminuta extracts was used relative gene expression of TNFa, IL-17re and IL-33 from epithelial cells and it was tested using real-time PCR. Our result showed that excretory/secretory products had the strongest antiinflammatory effect on the epithelial cells. We assume that crude adult extracts play an important role in increas

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Šalomová, Martina. "Změny motorických funkcí u myšího modelu cerebelární degenerace v průběhu ontogeneze." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-367899.

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The cerebellum affects a number of important and complex processes in the organism. It ensures coordination, motor learning and plays an important role in cognitive and affective functions. In the case of cerebellar degeneration, we find not only the movement disorders but also behavioral abnormalities, collectively referred to as cognitive-affective syndrome. The aim of this work was to investigate motor functions during ontogenesis in animal models of hereditary cerebellar degeneration - mutant mice Lurcher and Purkinje cell degeneration using the device for quantitative gait analysis and ro

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