Dissertations / Theses: 'Non-surgical treatment'

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Abitbol, Sarah. "Outcome of non-surgical endodontic treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62996.pdf.

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Ho, Kam-yuen Simon, and 何錦源. "Healing responses following surgical/non-surgical treatment in residual periodontally-involved sites." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B43895463.

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Ho, Kam-yuen Simon. "Healing responses following surgical/non-surgical treatment in residual periodontally-involved sites." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B36787681.

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Ng, Y. L. "Factors affecting outcome of non-surgical root canal treatment." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/14526/.

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Lee, Hui-cheng Angeline, and 李慧琴. "Long term outcome of primary non-surgical root canal treatment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45165853.

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Mak, Yun-lok Raymond. "Profile changes of putative periodontal pathogens after non-surgical periodontal treatment." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B31954236.

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Mak, Yun-lok Raymond, and 麥潤樂. "Profile changes of putative periodontal pathogens after non-surgical periodontal treatment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31954236.

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Apatzidou, Danae Anastasia. "Clinical, microbiological and immunological responses to two non-surgical periodontal treatment modalities." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394964.

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Pereira, Stephen Paul. "The pathogenesis and non-surgical treatment of gallstones : clinical and laboratory studies." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271458.

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Costa, Ricardo dos Santos Araujo. "Comparação dos tratamentos cirúrgico e não cirúrgico da perimplantite : análise clínica de 3 meses de um ensaio controlado randomizado." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/173858.

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As doenças perimplantares (DPi) vêm sendo consideradas umas das maiores causas de perdas tardias de implantes dentários e nenhum dos tratamentos já propostos na literatura mostrou ser eficiente a ponto de se tornar a primeira escolha terapêutica. Considerando que a definição correta do tratamento depende invariavelmente do entendimento da etiopatogenia, ocorrências e diagnóstico das DPi, o objetivo da presente tese foi abordar as DPi através de uma ampla revisão dos seus conceitos e da apresentação de dados clínicos preliminares de três meses de um ensaio clínico controlado randomizado comparando os resultados dos tratamentos cirúrgico (C) e não cirúrgico (NC) da perimplantite. Foram incluídos implantes apresentando um ou mais sítios com profundidade de sondagem perimplantar (PSi) ≥ 5mm, com presença de sangramento submucoso (SSi) e/ou supuração e apresentando perda óssea radiográfica (PO) ≥ 3mm. O tratamento não cirúrgico incluiu debridamento mecânico com curetas de teflon e irrigação com solução salina, assim como o tratamento cirúrgico, com acesso por retalho mucoperiostal. Não foram utilizadas técnicas ressectivas e nem implantoplastia. A amostra foi randomizada de maneira estratificada para o hábito de fumar e a presente análise, de 3 meses de acompanhamento após o tratamento, se refere à amostra de 22 indivíduos (29 implantes), sendo 12 (17 implantes) no grupo C e 10 (12 implantes) no NC. No início do estudo não foram observadas diferenças significativas entre os grupos para variáveis demográficas e clínicas, exceto nas condições periodontais de índice de placa visível (IPV) (NC 22,3±14,08 / C 40,2±19,9) e sangramento a sondagem (NC 15,9±10,2 / C 31,8±15,9). Após três meses de tratamento, não houve desistências e, considerando o pior sítio do implante, os dois tratamentos reduziram significativamente as medidas de PSi (NC 5,8±0,27 para 4,3±0,55mm / C 5,9±0,29 para 5,0±0,28mm), os dois grupos apresentaram redução de SSi mas apenas no grupo C foi significativa, diminuindo de 100% para 53%. Não houve diferenças entre os níveis de perda de inserção clínica (PIi). Em uma análise multivariada para identificar os preditores de sucesso dos tratamentos, implantes com PSi basal > 6 mm apresentaram piores reduções de PSi, SSi e PIi, o histórico de periodontite dificultou a redução de PSi enquanto indivíduos com 5 ou mais implantes e reabilitados com próteses cimentadas apresentaram piores reduções de SSi. A taxa de sucesso dos tratamentos foi de 33% no grupo NC e 17% para o grupo C sem diferenças estatísticas. Conclui-se que ambos os tratamentos diminuíram sinais inflamatórios embora sem a demonstração de diferenças entre eles, e que preditores de risco ao sucesso do tratamento devem ser investigados.
Peri-implant diseases (PiD) have been considered the major causes of late loss of dental implants, and none of the proposed treatments in the literature demonstrated to be efficient to become the first therapeutic choice. Considering that the correct definition of treatment depends invariably on the understanding of the etiopathogenesis, occurrence and diagnosis of PiD, the aim of the present theses was to approach PiD through a 9oné99ono f its concepts and presenting preliminary clinical data of 3 months from a randomized controlled 9oné9 comparing surgical (ST) and non-surgical (NST) treatments of peri-implantitis. Implants presenting pocket depth (PD) ≥5mm and bleeding on probing (Bosshardt et al.) with radiographic bone loss ≥3 mm were included in the study. NST included mechanical debridement of the implant with Teflon curets and irrigation with saline solution, whereas ST included the debridement with mucoperiostal flap. Ressective surgery and implantoplasty were not applied. The sample was randomized by stratification according to smoking habit, and the present 3-months analysis after treatment referes to 22 individuals (29 implants), 12 (17 implants) in ST and 10 (12 implants) in the NST group. At basliene, no significant differences were observed between groups for demographic and clinical variables, except for periodontal conditions of teeth in regards to visible plaque (NST 22.3±14.08% and ST 40.2±19.9%) and BOP (NST 15.9±10.2% and ST 31.8±15.9%). After 3 months, there were no drop-outs and, considering the worst site of each implant, the two treatments reduced significantly mean PD (NST 5.8±0.27mm to 4.3±0.55mm and ST 5.9±0.29mm to 5.0±0.28mm. Both groups presented reduction in BOP, but only in the ST the reduction was significant, decreasing from 100% to 53%. There were no significant differences in clinical attachment loss after 3 months in the two groups. In a multivariable analysis to identify predictors of treatment success, implants with baseline PD >6mm presented lower reduction in PD over 3 months, as well as BOP and CAL. Previous history of periodontitis lead to higher PD and individuals with more then 5 implants and rehabilitated with bonded prosthesis had higher BOP over time. It can be concluded that both treatments reduced signs of inflammation although without significant differences between them, and baseline PD, number of implants, history of periodontitis and type of prosthetic fixation may be used as predictors of clinical outcomes of peri-implantitis treatment.

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馮建裕 and Kin Yue Clive Fung. "The effects of non-surgical periodontal treatment on gingival suppuration, bleeding on probing and pocket depths in male tobaccosmoking and non-smoking adults." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B38628466.

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Wang, Xusheng. "Ultrasonic Generator for Surgical Applications and Non-invasive Cancer Treatment by High Intensity Focused Ultrasound." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS052/document.

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La technique de haute intensité ultrasons focalisés (HIFU) est maintenant largement utilisée pour le traitement du cancer, grâce à son avantage non-invasif. Dans un système de HIFU, une matrice de transducteurs à ultrasons est pilotée en phase pour produire un faisceau focalisé d'ultrasons (1M ~ 10 MHz) dans une petite zone de l'emplacement de la cible sur le cancer dans le corps. La plupart des systèmes HIFU sont guidées par imagerie par résonance magnétique (IRM) dans de nos jours. Dans cette étude de doctorat, un amplificateur de puissance de classe D en demi-pont et un système d'accord automatique d'impédance sont proposés. Tous deux circuits proposés sont compatibles avec le système IRM. L'amplificateur de puissance proposé a été réalisé par un circuit imprimé (PCB) avec des composants discrets. Selon les résultats du test, il a rendement de conversion en puissance de 82% pour une puissance de sortie conçue de 1,25W à une fréquence de travail de 3MHz. Le système d'accord automatique d'impédance proposé a été conçu en deux versions: une version en PCB et une version en circuit intégré (IC). Contrairement aux systèmes d'accord automatique proposés dans la littérature, il n'y a pas besoin de l'unité de microcontrôleur (MCU) ou de l'ordinateur dans la conception proposée. D'ailleurs, sans l'aide de composants magnétiques volumineux, ce système d'auto-réglage est entièrement compatible avec l'équipement IRM. La version en PCB a été conçue pour vérifier le principe du système proposé, et il est également utilisé pour guider à la conception du circuit intégré. La réalisation en PCB occupe une surface de 110cm². Les résultats des tests ont confirmé la performance attendue. Le système d'auto-tuning proposé peut parfaitement annuler l'impédance imaginaire du transducteur, et il peut également compenser l'impédance de la dérive causée par les variations inévitables (variation de température, dispersion technique, etc.). La conception du système d'auto-réglage en circuit intégré a été réalisé avec une technologie CMOS (C35B4C3) fournies par Austrian Micro Systems (AMS). La surface occupée par le circuit intégré est seulement de 0,42mm². Le circuit intégré conçu est capable de fonctionner à une large gamme de fréquence tout en conservant une consommation d'énergie très faible (137 mW). D'après les résultats de la simulation, le rendement de puissance de ce circuit peut être amélioré jusqu'à 20% comparant à celui utilisant le réseau d'accord statique
High intensity focused ultrasound (HIFU) technology is now broadly used for cancer treatment, thanks to its non-invasive property. In a HIFU system, a phased array of ultrasonic transducers is utilized to generate a focused beam of ultrasound (1M~10MHz) into a small area of the cancer target within the body. Most HIFU systems are guided by magnetic resonance imaging (MRI) in nowadays. In this PhD study, a half-bridge class D power amplifier and an automatic impedance tuning system are proposed. Both the class D power amplifier and the auto-tuning system are compatible with MRI system. The proposed power amplifier is implemented by a printed circuit board (PCB) circuit with discrete components. According to the test results, it has a power efficiency of 82% designed for an output power of 3W at 1.25 MHz working frequency. The proposed automatic impedance tuning system has been designed in two versions: a PCB version and an integrated circuit (IC) version. Unlike the typical auto-impedance tuning networks, there is no need of microprogrammed control unit (MCU) or computer in the proposed design. Besides, without using bulky magnetic components, this auto-tuning system is completely compatible with MRI equipment. The PCB version was designed to verify the principle of the proposed automatic impedance tuning system, and it is also used to help the design of the integrated circuit. The PCB realization occupies a surface of 110cm². The test results confirmed the expected performance. The proposed auto-tuning system can perfectly cancel the imaginary impedance of the transducer, and it can also compensate the impedance drifting caused by unavoidable variations (temperature variation, technical dispersion, etc.). The IC design of the auto-tuning system is realized in a CMOS process (C35B4C3) provided by Austrian Micro Systems (AMS). The die area of the integrated circuit is only 0.42mm². This circuit design can provide a wide working frequency range while keeping a very low power consumption (137 mW). According to the simulation results, the power efficiency can be improved can up to 20% by using this auto-tuning circuit compared with that using the static tuning network

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Daniels, Sheila Meghnot. "Comparison of surgical and non-surgical orthodontic treatment approaches on occlusal and cephalometric outcomes in patients with severe Class II division I malocclusions." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/5449.

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This study aimed to examine end-of-treatment outcomes of severe Class II Division I malocclusion patients treated with surgical or non-surgical approaches. This study tests the hypotheses that occlusal outcomes (ABO-OGS) at end of treatment will be similar while cephalometric outcomes will differ between these groups. A total of 60 patients were included: 20 of which underwent surgical correction and 40 of which did not. The end of treatment ABO-OGS and cephalometric outcomes were compared by Mann-Whitney U tests and multivariable linear regression models. Following adjustment for multiple confounders (age, gender, complexity of case, and skeletal patterns), the final deband score (ABO-OGS) was similar for both groups (23.8 for surgical group versus 22.5 for non-surgical group). Those treated surgically had a significantly larger reduction in ANB angle, 3.4 degrees reduction versus 1.5 degrees reduction in the non-surgical group (p=0.002). The surgical group also showed increased maxillary incisor proclination (p=0.001) compared to candidates treated non-surgically. This might be attributed to retroclination of incisors during treatment selection in the non-surgical group – namely, extraction of premolars to mask the discrepancy. Studies such as this are necessary because they begin to give practitioners view of not only the outcomes of a single treatment plan, but a comprehensive approach by providing evidence of the over-arching treatment used for successful treatment in both groups.

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Söder, Birgitta. "Studies on plaque distribution and gingival crevicular fluid after non-surgical treatment in smokers and non-smokers with periodontal diseases." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2887-8/.

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Tan, Siow Wah. "Factors affecting the length of survival of permanent teeth after first-time non-surgical root canal treatment." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31954303.

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Tan, Siow Wah, and 陳曉華. "Factors affecting the length of survival of permanent teeth after first-time non-surgical root canal treatment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31954303.

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Alsibaie, Lina. "Non surgical treatment strategies and outcomes in patients with class II division I malocclusion and severe overjet." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/3243.

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Background: Class II malocclusion is among the most common treated cases in orthodontics, yet there has not been a uniform consensus on the most effective and stable non-surgical treatment approach for class II division 1 malocclusion. Purpose: The purpose of this study is to assess effectiveness, long term stability, and quality of life following non-surgical orthodontic treatment in patients with Class II Division I malocclusion and severe overjet. Study Design: This study consists of a retrospective arm, analyzing the treatment approaches and effectiveness of class II division 1 with severe overjet, as well as a prospective arm assessing long-term stability and quality of life. Initial and final results for 30 patients treated non-surgically were analyzed by photos and lateral cephalometric radiographs. A post retention clinical exam was done for final measurements, assessment for practitioner and patient satisfaction, and patient quality of life questionnaires. Results: Non-surgical treatments for severe class II division 1 patients have shown to be statistically significant in effectively reducing overjet and overbite (P < 0.01) as well as improving the SNB and ANB angles (P<0.01) and angulation of maxillary incisors to SN plane (P < 0.05). Patient satisfaction was averaged at 4.1-4.3 (on a 5-point scale) for treatment, esthetics, and occlusion indicating good results and long-term stability. Quality of life assessments were also high based on the OHIP and CPQ. Conclusion: Non-surgical treatment to correct class II can significantly reduce overjet and overbite, SNB and ANB angles, as well as the angulation of maxillary incisors to SN plane. These treatment approaches have shown to be reliable in retention and stability of occlusion, as well as high results of patient satisfaction.

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Lawson, Sean. "The Prevalence of Intrapulpal Cracks in 1st and 2nd Mandibular Molars Requiring Non-Surgical Root Canal Treatment." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3410.

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Few studies have reported the incidence or prevalence of cracked teeth with pulpal involvement. No attempts have been made to evaluate the prevalence or clinical predictors for intrapulpal cracks. The purpose of this study was to investigate the prevalence of intrapulpal cracks in first and second mandibular molars and to determine if clinical findings are predictive for the existence of intrapulpal cracks. First and second mandibular molars (190) requiring non-surgical root canal treatment at the VCU Graduate Endodontic Practice between February 15, 2013 and August 15, 2013 were analyzed retrospectively. Teeth were transilluminated, stained, and inspected for intrapulpal cracks using a dental microscope. Data gathered included: demographics, subjective and objective information regarding the chief complaint to include bite stick test, transillumination, probing depths greater than 4mm, existing restorations, and diagnosis. Chi-square and logistic regression were performed (p<0.05). The prevalence of intrapulpal cracks in first and second mandibular molars combined was 9% (17/190, 95%CI= 5.7% to 13.9%). The prevalence was 7% for 1st molars and 13% for 2nd molars. There was no statically significant difference in the prevalence between first and second mandibular molars. Individual characteristics predictive for the existence of intrapulpal cracks were age, probing depth greater than 4mm, transillumination and a positive Tooth Slooth™ test (all p<0.05). Staining of the pulp chamber after access identified only one of 17 intrapulpal cracks. Staining of the pulp chamber did not significantly increase the ability to identify intrapulpal cracks. Neither diagnosis, sex, nor existing restorations were significant predictors for intrapulpal cracks. Probing depth greater than 4mm, age over 40 and a positive Tooth Slooth™ test were conjointly significant for predicting intrapulpal cracks.

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万鵬 and Peng Wan. "A clinical trial of local delivery of hyaluronic acid gel as an adjunct to non-surgical treatment of chronic periodontitis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31981859.

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Chan, Pui-sze, and 陳沛思. "Effects of modified Yunu Jian: a traditional Chinese medicine formula, in non-surgical periodontal treatment ofsmokers with periodontitis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634139.

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Puglisi, Rosario. "Evaluation of instrumentation systems for periodontal mechanical treatment." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/461097.

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A major objective in the treatment of periodontitis is to reduce supra-gingival and sub-gingival plaque, dental calculus, and prevent recolonization of periodontal pockets by pathogenic bacteria{{117 Braun,A. 2005; 118 Dragoo,M.R. 1992; 119 Kocher,T. 2000; 120 Loos,B. 1987;}}. It is important for the clinician to achieve a controlled surface free of calculus and an optimal oral hygiene control by patients{{88 Keogh,T.P. 1993; 90 Alves,R.V. 2004; 89 Alves,R.V. 2005;}}. Previous studies have reported beneficial results from scaling and root planning in both clinical and microbiological aspects.{{139 Caffesse,R.G. 1986; 140 Huerzeler,M.B. 1998; 141 Leknes,K.N. 1994; 120 Loos,B. 1987; 143 Quirynen,M. 1990;}} The aim of this study is to provide new and relevant data on scaling and root planing methods in order to value the effectiveness (different changes in plaque index, probing pocket depth, attachment level, and bleeding on probing) and the morbidity of four different instrumentation systems (sensitivity and pain). The main objective is to analyze individually each instrument to analyze the effectiveness and the morbidity; the secondary objective is to compare the various instrumentation systems with the "gold standard" for scaling and root planing (Curettes + Ultrasound). Objectives: The results of this study will provide new relevant data on scaling and root planing methods. Main Objective: The main objective is to analyze the clinical effectiveness of 4 different instrumentation systems and compare the results, in terms of clinical attachment level gain, to non surgical periodontal therapy (periodontal debridement). Secondary Objectives: 1. To analyze the post-treatment morbidity for each method. 2. To analyze the working-time for each method. Focus of the Thesis to achieve the objectives: This in vivo study compared the effectiveness and morbidity of four different instruments using a split mouth design. Patients were chosen at the first visit to the department of Periodontology of the Dental Clinic of the Universitat Internacional de Catalunya UIC. On the first visit patients underwent a comprehensive periodontal examination. The operator carried out an initial examination of the patient and filled out a questionnaire relevant to the patient’s general information. A Periodontal examination was performed with a periodontal probe (HU-Friedy® - Chicago.IL.USA - COD: PCPUNC15 30 - CP15) and a periodontal chart used in the University Dental Clinic . The following parameters were examined: - plaque index (PI) {{171 O'Leary,T.J. 1972;}} - probing pocket depth (PPD) - probing attachment level (PAL) - bleeding on probing (BOP) {{170 Benamghar,L. 1982;}} - gingival recession (REC): measurement from the cementum-enamel junction to the gingival marginal crest - mobility (MOB) (Miller 1950) - furcation involvement (FI) (Hamp et al. 1975) - sensitivity (tested by the operator) After completion of initial screening, each patient (that met the selection criteria) was informed about his/her periodontal status and the clinical study. Each patient agreed to participate by signing a consent form. No patient was admitted to the study until the Informed Consent Form is signed. Twenty (20) patients were selected to obtain the statistical significance of the results and the analyses was performed using a statistical program (Stratigrafics for Windows). A power calculation before the initiation of this study revealed that a sample size of 17 patients was necessary to detect a difference of 1 mm for each clinical parameter, assuming a maximal mean - standard deviation of 1 mm. Inclusion criteria: - Patients with generalized moderate to severe chronic periodontitis - PPD : at least two sites with probing depth ≥4mm per multi-rooted teeth, and at least three sites with probing depth ≥4mm for all remaining teeth, per quadrant. (like in other studies) (44). - Systemically healthy patient Exclusion criteria - Patients who had had antibiotic therapy in the last 2 month or during the study - Patient less of 18 years old - Smokers - Pregnant woman - Remaining dentition of less than 20 teeth - Recent periodontal treatment - Allergies to local anesthetics - Physically handicapped subject and/or with mental disorders, who cannot assume proper plaque control - Aggressive periodontitis - Acute periodontal or endodontic infection - Systemic disease: - Cardiovascular disease: uncontrolled hypertension, stable and unstable angina, recent heart attack (<1 month), heart attack (> 1 month without symptoms), arrhythmias, heart failure. - Lung disease: chronic obstructive pulmonary disease, tuberculosis - Gastrointestinal disease: chronic active hepatitis, cirrhosis, pseudomembranous colitis, renal disease. - Genitourinary disease: chronic renal failure, sexually transmitted diseases (gonorrhea, syphilis, genital herpes, papillomavirus infection). - Endocrine and metabolic disease: diabetes mellitus, renal failure, hypothyroidism and hyperthyroidism, uncontrolled tiroiditis, thyroid cancer, pregnancy and lactation. - Immune disease: HIV infection and related conditions, connective tissue disorders (lupus erythematosus, pemphigus vulgaris, penfogoide, Sjogren's syndrome), organ transplant (heart, liver, kidney, pancreas, bone marrow). - Hematological disorders: Anemia, agranulocytosis, cyclic neutropenia, leukemia, multiple myeloma, lymphomas, thrombocytopenia, vascular wall, hemophilia, von Willebrand disease, disseminated intravascular coagulation, thrombocytopenia, primary fibrinogenolisis. - Oncological disease: patients undergoing radiotherapy and chemotherapy. - Psychiatric illness, disease of the behavior, neurological disease: epilepsy, Parkinson's syndrome, anxiety, eating disorders, delirium, schizophrenia, depression and bipolar disorder untreated. This in vivo study compared four different instruments using a split mouth design. The split mouth design selected for this study is the division of the mouth into 4 parts, each part corresponded to a quadrant. Four groups were formed (one for each instrument) and each quadrant (of each patient) was assigned to one clinically randomized group. The realization of treatment for each patient was made randomly using an informatical function of randomization. Groups Group A: curettes (Hu-Friedy®) Specific curettes were used following this plan: Gracey curettes 5/6 --- anterior teeth Gracey curettes 11/12 --- mesial surface of premolar and molar Gracey curettes 13/14 --- distal surface of premolar and molar Group B: conventional piezoelectric ultrasound (Suprasson P-5 Booster - Satelec®) was applied at a power between 11 and 12 with the insert n.1 (Satelec®). The minute vibration frequency of this ultrasound is 28-36 KHz. Group C: diamond burs 40 µm (Intensiv Perioset®) at 3,000 rpm. Group D: piezoelectric ultrasound - Piezosurgery 3 - Mectron® was applied in On/Mode Periodontics (ROOT) mode with the insert PP1 at a power between 2 and 3. The minute vibration frequency of this ultrasound is 24-36 KHz. One reevaluation visit was performed 1 week after the treatment of each quadrant and a questionnaire was used to analyze the post-treatment morbidity. During this visit only the hypersensibility of each tooth was tested with an air-stimulation by the operator. At 8 weeks a data collection was performed by an expert periodontist (A.S.) who was blinded to the study. All important parameters for this study were recorded (as we mentioned for the Periodontal examination). The pooled data at baseline and two months after instrumentation were then used for the statistical analysis. Each clinical parameter (plaque index, probing pocket depth, probing attachment level, bleeding on probing, gingival recession, mobility, furcation involvement and sensitivity) was analyzed for each group and for a comparison between the groups. The comparison of the four instrumentation systems find out the method that shows better results. Results At 8-week re-evaluation, regarding attachment level gain and probing pocket reduction, Gracey’s curettes, conventional ultrasound, and ultrasound Piezosurgery resulted statistical more effective when compared with diamond burs. Regarding to chair side time, a statistical difference was shown (p<0.001) when suprasson ultrasound and ultrasound Piezosurgery were compared with the others instruments. The post-treatment morbidity after scaling and root planning was not statistical difference for all the analysed instrumentations. The statistical difference was shown between baseline and weeks 1 and 4, and between weeks 1 and 8, and between weeks 4 and 8, when all the results were evaluated together. Better results at 8-week re-evaluation were obtained from the use of conventional ultrasonic device: 3.04 ± 2.39 (SD) but no statistical significance difference was shown (p>0.05) when compared with other groups. Conclusions Conventional Gracey curettes (Hu-Friedy®), conventional ultrasound (P-5 Booster Suprasson Satelec®) and ultrasound Piezosurgery Mectron® are more effective clinically when compared with diamond burs 40 µm (Intensiv Perioset®). The ultrasound instrumentation showed better results in terms of chair side time. Clinical Relevance The use of conventional curettes, conventional ultrasound and ultrasonic piezoelectric Mectron device prove to be more effective than 40 µm diamond burs in the non-surgical periodontal treatment.

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Chan, Pui-sze. "Effects of modified Yunu Jian : a traditional Chinese medicine formula, in non-surgical periodontal treatment of smokers with periodontitis /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634139.

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Fung, Kin Yue Clive. "The effects of non-surgical periodontal treatment on gingival suppuration, bleeding on probing and pocket depths in male tobacco smoking and non-smoking adults." Click to view the E-thesis via HKUTO, 1994. http://sunzi.lib.hku.hk/HKUTO/record/B38628466.

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Soo, Lingfeng, and n/a. "A comparison of fluorescence-guided Er:YAG laser debridement and mechanical therapy for the non-surgical treatment of chronic periodontitis : a controlled prospective clinical study." University of Otago. School of Dentistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20090216.150022.

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Aims: The aim of this study was to compare two different methods of root surface debridement for the treatment of moderate to advanced chronic periodontitis; fluorescence-guided laser debridement using an Er:YAG laser (ERL) or mechanical scaling and root-planing (SRP/UL) using an ultrasonic scaler and hand instruments. The effectiveness of each treatment method was assessed by patient-centred outcomes such as clinical periodontal measurements and patients� overall experience. Methods: This study was a phase IV randomised controlled clinical trial, with all examinations and treatments carried out between 1st February 2007 and 7th March 2008. Using a split-mouth design, each patient received both test and control treatments. The control quadrants received scaling and root planing using a Piezon� (EMS, Nyon, Switzerland) ultrasonic scaler and Gracey curettes, while the test quadrants received fluorescence-guided Er:YAG laser root debridement (Keylaser 3, Kavo, Biberach, Germany; panel settings 160mJ/pulse, 10Hz, water spray, 655nm fluorescence calculus-detection system). Full mouth clinical measurements [plaque index (PlI), probing depth (PD), gingival recession (GR), bleeding on probing (BOP), and clinical attachment level (CAL)] were recorded at baseline, and 6 and 12 weeks post-therapy. A patient questionnaire was used to evaluate patient perception in terms of pain, discomfort and satisfaction during treatment, and 24 hours and one week post-treatment. A wash-out period of 6 weeks enabled each patient to evaluate their experience of each treatment on its own merit. Results: Twenty-eight patients received both treatments and completed the patient perception questionnaire. No significant difference was found between ERL and SRP/UL in terms of pain and discomfort during treatment, and 24 hours and one week post-treatment. In terms of patient satisfaction, none of the patients rated ERL more favourably than SRP/UL immediately following treatment, however no significant difference was found 24 hours later and one week post-therapy. Complete clinical data was collected for 22 patients, four of whom increased their tobacco consumption to [greater than or equal to] 10 cigarettes/day. Therefore, the analysis of clinical data was carried out twice with respect to patients� smoking status. In patients who smoked [less than or equal to] 9 cigarettes/day (n = 18 patients), ERL provided less PD reduction at 6 and 12 weeks (p < 0.001, 6 weeks; p < 0.05, 12 weeks) than SRP/UL. Even though SRP/UL quadrants had a greater proportion of sites with BOP (% BOP) at baseline, at 6 weeks they showed a significantly greater reduction in %BOP (p = 0.0123) than ERL quadrants, however there was with no significant difference in bleeding scores (p = 0.202) at 12 weeks post-therapy. When patients who smoked [greater than or equal to] 10 cigarettes/day were included in the analyses (n = 22 patients), ERL resulted in less BOP reduction and PD reduction at 6 and 12 weeks following treatment (BOP reduction: 6 weeks p < 0.05, 12 weeks p < 0.001; PD reduction: 6 weeks p < 0.01, 12 weeks p < 0.05). Although statistically significant, the differences between the treatment groups were very small and were not clinically significant. Conclusion: The use of ERL for root surface debridement offers no significant advantages over mechanical therapy in the treatment of moderate to advanced chronic periodontitis, in terms of clinical outcomes and patient perception of pain, discomfort or satisfaction related to the procedure.

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Wan, Peng. "A clinical trial of local delivery of hyaluronic acid gel as an adjunct to non-surgical treatment of chronic periodontitis." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31981859.

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Ho, Chun-sing Johnson, and 何晉陞. "Adjunctive use of a Chinese herbal medicine in the non-surgical mechanical treatment of advanced periodontal disease on smokers: a randomized clinical trial." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37651584.

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Holmér, Pettersson Pia. "Pain treatment after surgery : with special reference to patient-controlled analgesia, early extubation and the use of paracetamol /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-134-2.

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Greggianin, Bruna Frizon. "Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/142160.

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A Síndrome Metabólica (SM) é uma condição de prevalência crescente no mundo e existe pouca informação sobre o efeito do tratamento periodontal nos parâmetros metabólicos em pacientes com SM. O objetivo desta tese é comparar o efeito do tratamento periodontal nos níveis de hemoglobina glicada, glicose em jejum, triglicerídeos, colesterol HDL, colesterol total, insulina, resistência à insulina, função de células beta, proteína C reativa (PCR) e pressão arterial (PA) em pacientes com periodontite e SM em um período de 6 meses. Metodologia/ Desenho: Esta tese compreende uma análise parcial de um ensaio clínico randomizado com indivíduos com diagnóstico concomitante de periodontite _ ≥ 2 sítios interproximais com perda de inserção (PI) ≥4 mm ou ≥2 sítios interproximal com profundidade de sondagem (PS) ≥ 5mm em dentes não-adjacentes e não no mesmo dente e SM (Federação Internacional do Diabetes-2009). Setenta e dois indivíduos foram randomizados para grupo teste (tratamento periodontal imediato) ou controle (tratamento periodontal tardio-após 6 meses). Os pacientes receberam avaliação odontológica e realizaram exames sanguíneos nos tempos inicial, 3 e 6 meses, além de tratamento médico para hiperglicemia, dislipidemia e hipertensão quando necessário. O desfecho primário foi alteração na hemoglobina glicada e os desfechos secundários foram alterações na glicose, triglicerídeos, colesterol total e HDL, insulina, resistência à insulina, função de células beta, PCR e PA. A análise estatística foi realizada utilizando o modelo de Equações de Estimações Generalizadas (GEE: Generalized Estimating Equations). Resultados: Não houveram diferenças significativas nos parâmetros periodontais e metabólicos em ambos os grupos no exame inicial. Houve redução significativa de placa, sangramento marginal, fatores retentivos de placa, sangramento subgengival, média de PS e de PI no grupo teste. Não houve diferença significativa nos parâmetros metabólicos e na pressão arterial aos 3 e 6 meses comparando-se indivíduos que receberam tratamento periodontal ou não. Na análise intra-grupo, indivíduos do grupo controle reduziram os níveis de insulina e resistência à insulina e aumentaram colesterol HDL aos 3 e 6 meses. Na análise do percentil 75º de hemoglobina glicada e de sangramento subgengival, a comparação intra-grupo mostrou redução significativa de hemoglobina glicada no grupo teste dos 3 para os 6 meses, além de melhora no grupo controle de insulina, resistência à insulina e HDL. Conclusão: A despeito da melhora nos parâmetros periodontais no grupo teste, não houve efeito do tratamento periodontal nos parâmetros metabólicos e na PA.
Metabolic syndrome (MS) is a condition of increasing prevalence in the world and there is a little information on the effect of periodontal treatment on levels of metabolic parameters in patients with MS. The objective of this thesis is to compare the effect of periodontal treatment on levels of glycated hemoglobin, fasting glucose, triglycerides, HDL cholesterol, total cholesterol, insulin, insulin resistance, beta cell function, C-reactive protein (CRP) and blood pressure (BP) in patients with periodontitis and MS in a period of 6 months. Methods / Design: This thesis comprises a partial analysis of a randomized clinical trial with patients with concomitant diagnosis of periodontitis _ ≥ 2 interproximal sites with clinical attachment loss (CAL) ≥4 mm or ≥2 interproximal sites with probing depth (PD) ≥ 5mm in non-adjacent teeth and SM (International Diabetes Federation, 2009). Seventy-two subjects were randomly assigned to the test group (immediate periodontal treatment) or control (periodontal treatment after 6 months). Patients received dental evaluation and performed blood tests in baseline, 3 and 6 months, and medical treatment for hyperglycemia, dyslipidemia and hypertension when needed. The primary outcome was change in glycated hemoglobin and secondary outcomes were changes in glucose, triglycerides, total and HDL cholesterol, insulin, insulin resistance, beta cell function, CRP and BP. Statistical analysis was performed using Generalized Estimated Equations (GEE). Results: There is no significant differences in periodontal and metabolic parameters in both groups at baseline. There was a significant reduction of plaque, marginal bleeding, plaque retentive factors, subgingival bleeding, mean PS and PI in the test group. There is no significant difference in metabolic parameters and blood pressure at 3 and 6 months compared to subjects who received periodontal treatment or not. In the intra-group analysis, control subjects improved insulin levels, insulin resistance and HDL cholesterol at 3 and 6 months. In the analysis of 75 percentile of glycated hemoglobin and subgingival bleeding, intra-group comparison showed significant reduction of glycated hemoglobin in the test group of 3 to 6 months, and reduction in control group of insulin, insulin resistance and improvement of HDL. Conclusion: Despite the improvement in periodontal parameters in the test group, there was no effect of periodontal treatment on metabolic parameters and BP.

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Ho, Chun-sing Johnson. "Adjunctive use of a Chinese herbal medicine in the non-surgical mechanical treatment of advanced periodontal disease on smokers a randomized clinical trial /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37651584.

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Isik, Alexandra, and Tai Truong. "Efficacy of air-polishing in disinfecting implant surfaces. A laboratory study simulating a non-surgical approach." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-42547.

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Aim: To evaluate different parameters potentially affecting the efficacy of air-polishing devices in disinfecting implant surfaces in a non-surgical treatment approach of peri-implantitis lesions. Material and method: Altogether, 56 turned and 56 moderately rough implants were coated with a simulated biofilm. The implants were mounted in customized resin models simulating peri-implant 30° bone-defects, 3- and 5-mm deep; soft tissues were simulated with ballistic gelatin. Each implant was cleaned for 30 or 90 seconds in total (6 sites pr. implant; 5 or 15 seconds pr. site) with one of two different air-polishing devices (W&H and EMS). Implants were photographed in three different angulations and the amount of residual biofilm on the implant surface was measured digitally. Beta-regression models were used to assess the outcome. Results: Implant surface, treatment time and air-polishing device significantly affected the amount of residual biofilm. Turned implant surface, longer treatment time, and using the EMS device resulted in significantly less residual biofilm. In the most apical part of the defect, both air-polishing devices performed similarly, however, this was also the area with most biofilm left compared to more coronal aspects. Defect depth had no significant effect. Conclusion: Superior biofilm removal is achieved at implants with turned surface, and when applying longer treatment time. At the deepest aspect of the defect, implant decontamination is compromised.
Syfte: Syftet med denna laborativa studie är att utvärdera olika parametrar som potentiellt kan påverka effekten av air-polishing maskiner vid icke-kirurgisk rengöring av implantat för behandling av peri-implantit. Material och metod: Sammanlagt, 56 turned (maskin bearbetade) och 56 moderately rough (måttlig ytråhet) implantat var belagda med en biofilmimitation. Implantaten var placerade i en specialgjord resin-modell som simulerar en 30° bendefektmodell med 3- respektive 5 mm defektdjup; mjukvävnaden simulerades med ballistiskt gelatin. Varje implantat rengjordes i totalt 30 eller 90 sekunder (6 sidor per implantat; 5 eller 15 sekunder per sida) med en av två air-polishing maskiner (W&H och EMS). Implantaten fotograferades sedan ur tre olika vinklar för att digitalt bedöma kvarstående biofilm. Implantatyta, tillverkare, defektdjup och behandlingstid analyserades som prediktionsvariabler för kvarstående biofilm (%). Beta-regressionsanalys användes för att bedöma resultatet. Resultat: Implantat-yta, tillverkare och behandlingstid påverkade mängden kvarvarande biofilmsimulation signifikant. Maskinbearbetade implantatytor, en längre behandlingstid, användande av EMS maskinen, resulterade alla i signifikant mindre kvarvarande biofilm. De två tillverkarna presterade endast lika i de mest apikala delarna av defekten, men detta var också det område med mest kvarvarande biofilm jämfört med mer koronala aspekter. Defekt djup hade ingen signifikant effekt på resultatet. Slutsats: Man kan förvänta sig bättre borttagning av biofilm när man behandlar maskinbearbetade implantatytor samt när man använder en längre behandlingstid.Vid den djupaste aspekten av defekten, äventyras dekontaminering av implantat

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31

Winnerkvist, Anders. "Management of thoracoabdominal aortic aneurysms and dissections : with emphasis on spinal cord protection in aneurysm repair and non-surgical treatment of type-B dissection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-768-5/.

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Fike, Jeremy W. DDS. "Assessment of changes in the size of periapical radiolucencies 3-12 months post non-surgical root canal treatment using CBCT imaging: A pilot study." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4139.

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The purpose of this study was to assess the changes in size of periapical lesions 3-12 months following root canal treatment using CBCT. Patients who had non-surgical root canal therapy (NSRCT) or non-surgical retreatment (ReTx) from July 30,2014 to August 19, 2015 with a periapical lesion of endodontic origin and received NSRCT or ReTx and had a pre-treatment or intra-treatment CBCT were invited to participate. Volumetric and linear measurements of periapical lesions on initial and post- treatment CBCT images were performed. A total of 20 patients with 23 treated teeth with 30 separate periapical radiolucent lesions returned for follow up 91-390 days after the initiation of endodontic treatment. Lesions showed an overall reduction in volume (p=0.0096), maximum coronal diameter (p=0.0117), maximum sagittal diameter (p=0.0071), and maximum axial diameter (p=0.0006). Lesions show a significant reduction in size 3-12 months following non-surgical endodontic treatment using CBCT.

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Silva, Emílio Barbosa e. [UNESP]. "Avaliação clínica e microbiológica de diferentes modalidades de terapia periodontal não-cirúrgica em pacientes com periodontite crônica." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/104724.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O objetivo deste estudo foi avaliar em pacientes portadores de periodontite crônica avançada, os efeitos de diferentes modalidades de tratamento periodontal não-cirúrgico na composição microbiana subgengival e nos parâmetros clínicos de avaliação da doença periodontal em diferentes tempos de análise. Foram avaliados 30 pacientes com idade entre 25 e 68 anos com profundidade à sondagem inicial d 6mm e = 8 mm nos sítios selecionados. Estes pacientes foram divididos em três grupos, cada um contendo 10 pessoas de acordo com o tratamento realizado: Grupo 1 - realização de raspagem e alisamento radiculares supra e subgengivais concomitantemente no mesmo dia; Grupo 2 - realização de raspagem alisamento e polimento supragengival e 7 dias após realização de raspagem e alisamento radiculares subgengival; Grupo 3 - realização de raspagem alisamento e polimento somente supragengival por 30 dias e complementação da raspagem subgengival após este período. Os pacientes foram avaliados antes e após 7, 15, 30 e 60 dias de realizado o procedimento inicial pelos seguintes parâmetros clínicos: profundidade de sondagem, nível de inserção, sangramento à sondagem, presença de placa, inflamação gengival e supuração. Também foram realizadas coletas de amostras de placa subgengival nos mesmos sítios e períodos e analisadas a prevalência e os níveis de 36 espécies bacterianas pela técnica do checkerboard DNA-DNA hybridization. Como resultados deste estudo verificamos que a profundidade de sondagem foi significativamente reduzida pelos tratamentos de raspagem supra e subgengival concomitante e raspagem supra 7 dias prévios a subgengival. O grupo que recebeu somente raspagem supragengival até o 30º dia não apresentou melhora até este período, com uma redução significativa após a complementação da raspagem... .
The purpose of the present investigation was to evaluate the effects of different modalities of non-surgical periodontal treatment in 30 patients with advanced chronic periodontitis. Subjects were monitored clinically and microbiologically prior and 7, 15, 30 and 60 days after this three periodontal treatments: Group 1 - concomitant supra and subgingival scaling and root planning; Group 2 - supragingival scaling 7 days prior to subgingival scaling and root planning; Group 3 - supragingival scaling 30 days prior to subgingival scaling and root planning. Clinical assessment of plaque, redness, suppuration, bleeding on probing, pocket depth and clinical attachment level were made in two anterior teeth per patient. Subgingival plaque samples were taken at the same sites and the presence and levels of 36 subgingival bacteria species were determined using checkerboard DNA-DNA hybridization. The mean levels and % colonized by each species (prevalence) was computed for each subject at each visit. As results of this study was verified that pocket depth was significantly reduced for group 1 and 2. The group that received only supragengival scaling until the 30th day didn't improve until this period, with a significant reduction after the complementation of subgengival scaling and root planning. The clinical attachment level parameter didn't demonstrate significant alteration in none of the three groups along the time. However all the groups showed improvement or stability in this parameter, tends the group 1 presented the best results, followed for the group 2 and 3, respectively. All the groups didn't present differences between the initial period and the times of 30 and 60 days in relation to the other parameters of clinical evaluation, except for the gingival redness that had group 2 with better results, followed for the group 1 and 3... (Complete abstract, click electronic address below).

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Silva, Emílio Barbosa e. "Avaliação clínica e microbiológica de diferentes modalidades de terapia periodontal não-cirúrgica em pacientes com periodontite crônica /." Araraquara : [s.n.], 2004. http://hdl.handle.net/11449/104724.

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Orientador: Benedicto Egbert Corrêa de Toledo
Banca: Enilson Antônio Sallum
Banca: Márcio Fernando de Moraes Grisi
Banca: Silvana Regina Perez Orrico
Banca: Valdir Gouvêia Garcia
Resumo: O objetivo deste estudo foi avaliar em pacientes portadores de periodontite crônica avançada, os efeitos de diferentes modalidades de tratamento periodontal não-cirúrgico na composição microbiana subgengival e nos parâmetros clínicos de avaliação da doença periodontal em diferentes tempos de análise. Foram avaliados 30 pacientes com idade entre 25 e 68 anos com profundidade à sondagem inicial d 6mm e = 8 mm nos sítios selecionados. Estes pacientes foram divididos em três grupos, cada um contendo 10 pessoas de acordo com o tratamento realizado: Grupo 1 - realização de raspagem e alisamento radiculares supra e subgengivais concomitantemente no mesmo dia; Grupo 2 - realização de raspagem alisamento e polimento supragengival e 7 dias após realização de raspagem e alisamento radiculares subgengival; Grupo 3 - realização de raspagem alisamento e polimento somente supragengival por 30 dias e complementação da raspagem subgengival após este período. Os pacientes foram avaliados antes e após 7, 15, 30 e 60 dias de realizado o procedimento inicial pelos seguintes parâmetros clínicos: profundidade de sondagem, nível de inserção, sangramento à sondagem, presença de placa, inflamação gengival e supuração. Também foram realizadas coletas de amostras de placa subgengival nos mesmos sítios e períodos e analisadas a prevalência e os níveis de 36 espécies bacterianas pela técnica do "checkerboard DNA-DNA hybridization". Como resultados deste estudo verificamos que a profundidade de sondagem foi significativamente reduzida pelos tratamentos de raspagem supra e subgengival concomitante e raspagem supra 7 dias prévios a subgengival. O grupo que recebeu somente raspagem supragengival até o 30º dia não apresentou melhora até este período, com uma redução significativa após a complementação da raspagem... (Resumo completo, clicar acesso eletrônico abaixo).
Abstract: The purpose of the present investigation was to evaluate the effects of different modalities of non-surgical periodontal treatment in 30 patients with advanced chronic periodontitis. Subjects were monitored clinically and microbiologically prior and 7, 15, 30 and 60 days after this three periodontal treatments: Group 1 - concomitant supra and subgingival scaling and root planning; Group 2 - supragingival scaling 7 days prior to subgingival scaling and root planning; Group 3 - supragingival scaling 30 days prior to subgingival scaling and root planning. Clinical assessment of plaque, redness, suppuration, bleeding on probing, pocket depth and clinical attachment level were made in two anterior teeth per patient. Subgingival plaque samples were taken at the same sites and the presence and levels of 36 subgingival bacteria species were determined using checkerboard DNA-DNA hybridization. The mean levels and % colonized by each species (prevalence) was computed for each subject at each visit. As results of this study was verified that pocket depth was significantly reduced for group 1 and 2. The group that received only supragengival scaling until the 30th day didn't improve until this period, with a significant reduction after the complementation of subgengival scaling and root planning. The clinical attachment level parameter didn't demonstrate significant alteration in none of the three groups along the time. However all the groups showed improvement or stability in this parameter, tends the group 1 presented the best results, followed for the group 2 and 3, respectively. All the groups didn't present differences between the initial period and the times of 30 and 60 days in relation to the other parameters of clinical evaluation, except for the gingival redness that had group 2 with better results, followed for the group 1 and 3... (Complete abstract, click electronic address below).
Doutor

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Maltagliati, Luciana Avila. "Avaliação longitudinal do tratamento periodontal em mulheres com osteoporose." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-13042013-105835/.

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A interrelação de fatores como o avanço da idade, aliado às condições sócio-econômicas e à vulnerabilidade social, refletem na proeminência de doenças crônicas como a osteoporose e a doença periodontal. Tendo em vista que a perda óssea é a principal consequência para ambas as doenças, a osteoporose e a doença periodontal podem estar relacionadas. Considerando o limitado número de estudos longitudinais sobre a associação entre osteoporose e doença periodontal, o objetivo do nosso estudo foi avaliar, através de parâmetros clínicos periodontais, o efeito da osteoporose sobre os resultados do tratamento periodontal não-cirúrgico em mulheres na pós-menopausa, acompanhadas por um ano. Delineou-se um ensaio clínico controlado, duplo cego, para avaliar trinta e cinco mulheres selecionadas divididas em dois grupos: o grupo OST, composto por dezoito mulheres com diagnóstico de periodontite e osteoporose e o grupo controle (CTRL), composto por dezessete mulheres diagnosticadas para periodontite, porém, sistemicamente saudáveis. O efeito do tratamento periodontal não cirúrgico foi avaliado por meio das mensurações dos parâmetros clínicos como índice de placa bacteriana, sangramento à sondagem, profundidade de sondagem e nível clínico de inserção após o tratamento, nos períodos de três e doze meses. Assumindo-se como resultado principal a diferença no nível clínico de inserção, aos doze meses após o tratamento periodontal, utilizou-se o teste student t para amostras pareadas na análise intra-grupo e, para a comparação entre os grupos, o teste t para amostras independentes. Observou-se que o tratamento periodontal foi efetivo e ambos os grupos mostraram melhora em todos os parâmetros estudados após tratamento periodontal, quando comparado aos valores iniciais (p<0,05), houve ganho de inserção clínica para ambos os grupos, aos doze meses de avaliação, não havendo, porém, diferença estatisticamente significante entre os grupos (p>0,05). Não pudemos observar, dentro das limitações deste estudo, a interferência da osteoporose sobre as alteraçôes dos parâmetros clínicos periodontais após um ano de avaliação dos resultados do tratamento não cirúrgico da peridontite em mulheres na pós-menopausa.
To date no studies have evaluated the effect of osteoporosis on non-surgical periodontitis treatment. The aim of the present study was to evaluate the effect of osteoporosis on non-surgical periodontal therapy in post-menopausal women with chronic periodontitis. 35 women diagnosed with slight to moderate periodontitis were divided in two groups: osteoporotic (OST, n=18) and non-osteoporotic (CTRL, n=17) women. The effect of non-surgical periodontal treatment was assessed by measuring the changes in plaque (PI) and bleeding on probing (BOP) scores, probing depth (PD) and clinical attachment level (CAL) during one year. Only sites with baseline PD 4mm were used for statistical analysis. The periodontal therapy resulted in significant improvements for both groups. At the end of twelve months, the mean PI, BOP, PD and CAL for the OST group were 27.2 ±17.7, 2.6 ±3.0, 2.5 ±0.7, 3.6 ±1.3, respectively, versus 30.2 ±17.0, 8.4 ±10.6, 3.2 ±1.2, 4.3 ±1.5, respectively, for the control group. Using an individual-based analysis and Student t test for unpaired and paired observations (significance of differences between and within groups, respectively), women in CTRL group showed enhanced in BOP and PD scores (p<0.05) over a period of 12 months compared with those in OST group but no significant difference was found between the groups for PD and CAL difference changes (p>0,05). Within the limits of the present study, it can be concluded that osteoporosis did not influence the result of non-surgical periodontal therapy in slight to moderate periodontitis, the effect of osteoporosis condition on changes in clinical parameters could not be observed after one year post non-susrgical periodontal treatment.

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Cirino, Camila Camarinha da Silva 1986. "Avaliação clínica e microbiológica do tratamento cirúrgico e não-cirúrgico de pacientes com periodontite agressiva generalizada = ensaio randomizado com acompanhamento de 12 meses = Clinical and microbiological evaluation of surgical and non surgical treatment of generalized aggressive periodontitis : a 12-month follow-up randomized trial." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290415.

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Orientador: Antônio Wilson Sallum
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O presente estudo teve o objetivo de avaliar clínica e microbiologicamente o efeito das terapias periodontais cirúrgica e não cirúrgica em um período de 12 meses no tratamento da periodontite agressiva generalizada (PAG). Quinze pacientes diagnosticados com PAG foram incluídos neste estudo com desenho experimental de boca dividida. Os quadrantes superiores foram submetidos ao tratamento, e foram alocados em dois grupos: Grupo TNC (terapia não-cirúrgica) ¿ debridamento ultrassônico associado a raspagem manual; e Grupo TC (terapia cirúrgico) ¿ acesso cirúrgico para debridamento ultrassônico associado a raspagem manual. No baseline, e aos 3, 6 e 12 meses pós terapia, foram avaliados os seguintes parâmetros clínicos: índice de placa (IP), índice de sangramento à sondagem (ISS), profundidade de sondagem (PS), nível de inserção clínica (NIC) e posição da margem gengival (PMG). Nos mesmos períodos foram determinados os níveis de concentração de Porphyromonas gingivalis (Pg) e Aggregatibacter actinomycetemcomitans (Aa) no biofilme subgengival. Os resultados indicaram que a TC foi capaz de promover maior redução de PS quando comparada à TNC, em bolsas profundas, aos 12 meses (5,9±1,2 mm e 4,8±0,6 mm, TNC e TC respectivamente, p < 0,05), e também em dentes posteriores aos 6 meses de acompanhamento (4,8±0,8 mm e 4,1±1,3 mm, TCN e TC, respectivamente, p < 0,05). Além disso, foi observada maior recessão gengival em dentes posteriores do grupo TC, aos 6 meses, comparados ao baseline (-0,2±0,2mm e -0,7±1,2 mm, TCN e TC, respectivamente, p < 0,05). A avaliação microbiológica não demonstrou diferença estatística nos níveis de Aa e Pg para ambos os grupos em todos os períodos de acompanhamento. Pode-se concluir que, apesar de ambas a terapias não terem sido capazes de reduzir os níveis de Aa e Pg, clinicamente a terapia cirúrgica promoveu maior redução de PS em bolsas profundas e dentes posteriores
Abstract: The present study aimed to evaluate clinically and microbiologically the effects of surgical and non- surgical periodontal therapy in a 12-month period in the treatment of generalized aggressive periodontitis (GAgP). Fifteen patients with GAgP were included in this randomized controlled clinical study with experimental split-mouth design. Superior quadrants were treated, and allocated into two groups: Non-Surgical Therapy Group (NST) - ultrasonic debridement associated with manual scaling, and Surgical Therapy Group (ST) - access to surgical ultrasonic debridement associated with scaling manual. At baseline and at 3, 6 and 12 months after treatment, the following clinical parameters were assessed: plaque index (PI), bleeding on probing index (BoP), probing depth (PD), clinical attachment level (CAL) and gingival margin position (GMP). In same periods were determined the concentrations of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa) in subgingival biofilm. The results showed that ST was able to promote further PS reduction compared to the NST, in deep pockets, at 12 months (5.9 ± 1.2 mm and 4.8 ± 0.6 mm, NST and ST respectively, p < 0.05) and also in posterior teeth at 6 months follow-up (4.8 ± 0.8 mm and 4.1 ± 1.3 mm, NST and ST, respectively, p < 0.05). In addition, it was observed higher gingival recession in posterior teeth of ST group at 6th month, comparing to baseline (-0.2 ± 0.2 and -0.7 ± 1.2 mm, NST and ST, respectively, p < 0.05). The microbiological evaluation showed no statistical difference in the levels of Aa and Pg for both groups at all follow-up periods. It can be concluded that, althought both therapy failed do reduce the levels of Aa and Pg, clinically the surgical therapy promoted more PD reduction in deep pockets and posterior teeth
Doutorado
Periodontia
Doutora em Clínica Odontológica

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Tong, King-hung Daniel, and 唐琼雄. "Surgical treatment for type II diabetes mellitus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193510.

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Introduction: Historically, type 2 diabetes (T2DM) has been regarded as a progressive and degenerative disease and only minority of patients can have disease remission with conventional treatment. It was noticed that gastrointestinal surgery could induce complete remission of T2DM in most of morbidly obese patients. Compared to the West, the development of bariatric and metabolic surgery is slow in Hong Kong. It is unknown whether the knowledge and attitudes of medical doctors and patients towards surgical treatment for T2DM have impacts on the development in this field. The novel procedure sleeve gastrectomy (SG) had been shown to be effective in inducing T2DM remission in obese human. Duodenal jejunal bypass (DJB) and ileal transposition (IT) were reported to be effective for ameliorating T2DM in non-obese diabetic animal model. The anti-diabetic potency of DJB and IT is unknown in comparing to SG particularly in non-obese subjects. Currently, SG is the main procedure for morbidly obese patients with or without T2DM in the authors’ institution. Aims: The aims of the present thesis were to investigate the knowledge and attitudes of medical doctors and patients toward using surgery as a treatment for T2DM, to compare the anti-diabetic effect of SG, DJB and IT in non-obese T2DM animal model, and lastly, to review of outcomes of morbidly obese patients who underwent SG in authors’ institution. Methods: Survey was conducted using questionnaire for interview of both doctors and patients to investigate their knowledge and attitudes toward surgical treatment of T2DM. The anti-diabetic effects of novel surgical procedures SG, DJB and IT were compared using non-obese T2DM animal model (Goto Kakizaki rats). The outcomes were evaluation by measuring fasting glucose and glycosylated haemoglobin (HbA1c) levels. Other parameters including alteration in gut hormones and lipid profile were also analyzed. The outcomes of morbidly obese patients who underwent laparoscopic SG in last 5 years in the authors’ institution were retrospectively reviewed. Results: The knowledge of bariatric and metabolic surgery was inadequate both in medical doctors and patients. The attitude and pattern of referral from medical doctors depends on the amount of knowledge. Patients’ attitudes were positive and they accept surgery as a treatment option for T2DM as long as they were provided with adequate information. This implies that tremendous educational works are required both for medical doctors and patients for the development of bariatric and metabolic surgery in Hong Kong. All 3 procedures (SG, DJB and IT) significantly improved glucose homeostasis and the effect was more potent and durable in DJB and IT than SG. The improved glucose homeostasis in IT was resulted from increased GLP-1 and PYY secretion (hindgut theory). In DJB, GIP, GLP-1 and PYY were raised and the anti-diabetic effect could be explained both by the foregut and hindgut theories. SG reduced the diet triglyceride absorption. DJB reduced cholesterol absorption whereas IT reduced cholesterol but increase triglyceride absorption. The outcomes of SG for T2DM for morbidly obese patients were promising. More than 90% patients had T2DM ameliorated and 70% had complete remission. SG can effectively control the body weight of morbidly obese patients. Conclusion: Education, both to doctors and patients, was crucial to overcome the potential obstacles for the development of this newly specialty. The anti-diabetic effects of DJB and IT were more potent than SG in non-obese diabetic animal model. The lipid absorption varied in different surgical procedures. Application of these procedures in non-obese T2DM patients warrants individual consideration and further investigation. SG in the authors’ institution was effective to induce T2DM remission in morbidly obese patients.
published_or_final_version
Surgery
Doctoral
Doctor of Philosophy

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Barros, Fabiana Cervos de. "Efeitos do tratamento periodontal não cirúrgico sobre a densidade e altura óssea alveolar." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5101.

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O objetivo deste trabalho foi avaliar o efeito do tratamento periodontal não cirúrgico (TPNC), na densidade e na altura óssea alveolar, em pacientes com periodontite, utilizando radiografias digitais diretas. Cento e um sítios, em dezenove pacientes (idade média 36 7.3 anos) foram acompanhados no dia 0, e 90 e 180 dias após TPNC. Os índices clínicos de profundidade de bolsa a sondagem (PBS), nível de inserção clínica, sangramento à sondagem e índice de placa foram registrados e radiografias digitais foram feitas. A densidade foi analisada através de regiões ósseas de interesse colocadas sobre a crista óssea alveolar (ROI I) e sobre o osso medular (ROI II). A altura óssea alveolar foi medida através da distância da crista óssea alveolar até a junção cemento esmalte. Os sítios profundos (PBS ≥ 5mm) apresentaram uma melhora clínica significante (p <0.01), acompanhada de um aumento na densidade da ROI I (p <0.01). A ROI II mostrou um aumento na densidade dos sítios com PBS ≤ 3mm em pacientes com periodontite agressiva (p <0.05). No entanto, houve diminuição nos sítios com PBS ≥ 5mm nesses mesmos pacientes (p <0.03). A altura óssea alveolar não sofreu alteração após TPNC. Após o tratamento periodontal não cirúrgico, observou-se que as radiografias obtidas através da técnica digital direta parecem mostrar um aumento na densidade da crista óssea, nos sítios profundos dos pacientes com periodontite. No entanto, a redução da profundidade de bolsa e do ganho no nível de inserção clínica não foi acompanhada por alterações significantes na altura óssea alveolar nestes sítios.
The aim of this study was to access the effects of non-surgical periodontal treatment (NSPT), on the bone density and alveolar bone height (ABH), in patients with periodontitis, using direct digital radiographs. One hundred one sites in nineteen patients (mean age 36 7.3 years) were accompanied on day 0, and 90 and 180 days after the TPNC. The clinical scores of probing pocket depth (PPD), clinical attachment level, bleeding on probing and plaque index were registered and digital radiographs were taken. The density was accessed considering the bone regions of interest at the alveolar bone crest (ROI I) and the medullar bone (ROI II). The ABH measured the distance between the alveolar bone crest and the cementoenamel junction. The deep sites (PPD ≥ 5mm) presented a clinical improvement (p <0.01), accompanied by an increase in bone density at ROI I (p <0.01). ROI II showed an increase in density at sites with PPD ≤ 3mm in patients with aggressive periodontitis (p <0.05). However, there was a decrease in density in sites with PPD ≥ 5mm of the same patients (p <0.03). The ABH didnt change after TPNC. After non-surgical periodontal treatment, the direct digital radiographs showed a significant increase in bone crest density of deep sites in patients with periodontitis. Moreover, the reduction in the probing pocket depth and the increase in the attachment level were not followed by changes in alveolar bone height in these sites.

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Radoje, Simić. "Kliničke i patohistološke karakteristike urođenog rascepa vrata u prednjoj srednjoj liniji i njihov značaj za diferencijalnu dijagnozu i hirurško lečenje." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94511&source=NDLTD&language=en.

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Urođeni rascep sa naborom u prednjoj srednjoj liniji vrata (UR-N PSLV) je retka anomalija sa oko 100-150 bolesnika opisanih u literaturi. Tipičan rascep se sastoji od atrofične, ružičaste kože u obliku žleba, kožne prominencije na gornjem kraju i potkožnog sinusa na donjem kraju tzv. rascepa. Ispod ovih elemenata nalazi se potkožna vezivno-mišićna traka koja izaziva nabor na vratu. Izolovani nabor vrata, kao jedan od tipova rascepa, ima samo potkožnu traku i podbradnu kožnu izraslinu. U radu analiziramo seriju od 11 bolesnika sa UR-N PSLV operisanih u periodu od 12 godina (jul 1998. - jun 2010.). Rezultati lečenja sagledani su u pogledu preciznosti postavljanja dijagnoze (diferencijalna dijagnoza anomalija i oboljenja PSLV) i analize posleoperativnih funkcionalnih i estetskih karakteristika (vrednost cervikomentalnog ugla-CMU, veličina ekstenzije glave i vrata-EGV i karakteristike ožiljka). Rezultati operativnog lečenja rascepa primenom multiple „Z” plastike sa 4-10 kožnih režnjeva poređeni su sa Sistrunkovom operacijom kod bolesnika sa cistom tiroglosnog duktusa-TGDC (ukupno 128 bolesnika u seriji). S obzirom na veliki broj bolesnika sa različitim izgledom anomalije učinjena je podela UR-N PSLV na tipove (I-IV) i podtipove. Rascep se po embriopatogenezi, izgledu i patohistološkim (PH) karakteristikama jasno razlikuje od TGDC. Deskriptivnom embriologijom rascep se definiše kao poremećaj u spajanju prednjih krajeva II (nekad i I) ždrelnih lukova. Kompresija srca u razvoju i odloženo ispravljanje vrata imaju značajnu ulogu. Kožna izraslina je rabdomiomatozni mezenhimalni hamartom kod svih naših bolesnika. Kaudalni sinus po PH izgledu ukazuje na bronhogeno poreklo. Operacijom rascepa vrata ne postiže se normalan CMU i potpuna EGV. Operacijom TGDC više se menja CMU nego EGV, ali su vrednosti bliže kontrolnoj grupi nego kod dece sa rascepom. Ožiljci, posebno kosi delovi „Z” plastike, posle operacije UR-N su lošije ocenjeni nego posle operacije TGDC (parametrijski testovi pokazuju manju razliku). Na estetiku i funkcionalnost vrata i glave posle operacije rascepa veoma mnogo utiču hipoplazija donje vilice i deficit mekih struktura prednje strane vrata. Nova operativna tehnika (poprečna eliptična ekscizija i incizija u dva nivoa ili step incision, sa dodatnom „Z” plastikom na platizmi) primenjena kod dva bolesnika (pri kraju analize rezultata u studiji) daje nadu u dobijanje boljih posleoperativnih rezultata.
Congenital midline cervical cleft and web (CMCC-W) is a rare anomaly with about 100-150 cases described in the literature. The typical CMCC consists of midline groove of atrophic, erythematous skin with a skin protuberance cranially, and a subcutaneous blind sinus tract on the lower end of so-called cleft. Subcutaneous fibro-muscular band is located underneath, causing the web. Isolated CMCW, as one of the cleft types, includes only subcutaneous band and submental skin prominence. We analyzed a series of 11 patients with CMCC-W during the 12-year period (July 1998-June 2010). Treatment outcomes were evaluated according to precisely established diagnosis (differential diagnosis of anomalies and diseases of midline neck) and analysis of postoperative functional and aesthetic features (value of cervico-mental angle (CMA), head and neck extension (HNE) and characteristics of the scar). The results of the surgical treatment using multiple Z-plasty technique with 4-10 skin flaps were compared with Sistrunk procedure in patients with thyroglossal duct cyst (TGDC) (total of 128 patients in the series). Since a great number of patients had different forms of anomaly, the cases were divided into types (I-IV) and subtypes. Regarding embryo pathogenesis, appearance and histopathology, there was a clear difference between CMCC and TGDC. A cleft is defined, due to descriptive embryology, as a failure of the second (sometimes and first) pharyngeal arches to fuse in the midline. Compression of the heart and postponed extension of the neck played an important role during development period. Skin prominence was a rhabdomyomatous mesenchymal hamartoma in all our patients. Histopathology of the caudal sinus indicated the bronchogenic origin. The normal CMA and complete HNE were not achieved by the operation of CMCC-W. TGDC operation effects more CMA than HNE, but the values are closer to control group than in children having a cleft. Scars, especially oblique parts of Z plasty, after the operation CMCC-W were worse than after TGDC (parametric tests showed lesser difference). Hypoplasia of the mandible and vertical soft-tissue deficit of the anterior neck have a great impact on aesthetics and functionality of the head and neck after cleft surgery. New operative technique (two level transverse elliptical excision and incision or step incision – with the additional Z-plasty of platysma) was applied in two patients (at the end of the analysis of the results in the study) gives a new hope regarding better postoperative results.

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Golub, Samardžija. "Patohistološka procena tumorske regresije kod nemikrocelularnih karcinoma pluća posle neoadjuvantne terapije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101318&source=NDLTD&language=en.

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Karcinomi pluća su najčešći uzrok oboljevanja i umiranja od malignih tumora u Svetu. Neodjuvantna terapija kod bolesnika sa lokalno uznapredovalim (IIIA-IIIB) karcinomom pluća i zahvaćenim N2 limfnim čvorovima jedan je od modusa multimodalnog lečenja bolesnika sa nemikrocelularnim karcinomima pluća (NSCLC) u cilju poboljšanja ishoda njihovog lečenja. Ovakav pristup podrazumeva prevođenje bolesnika iz višeg u niži stadijum bolesti - „downstaging”. Do danas nije utvrđena povezanost između pojedinih obrazaca tumorskog odgovora i vrste terapije. S obzirom na značaj kompletnog patološkog odgovora i tumorske regresije u prognozi ishoda lečenja, iznalaženje ove povezanosti je od značaja za dizajniranje budućih neoadjuvantnih trajala. Prilikom utvrđivnja histološke slike tumorske regresije veoma je važno i merenje areje rezidualnog tumora (ART). Kako je veličina tumora jedan od prognostičkih faktora za bolesnike sa NSCLC koji nisu primali neoadjuvantnu terapiju tako je i merenje ART, za razliku od makroskopske veličine tumora, jedan od prognostičkih faktora za bolesnike sa NSCLC koji su primali neoadjuvantnu terapiju. Krajnji cilj neoadjuvantne terapije trebalo bi da bude resektabilnost i „downstaging” koji bi mogao da obezbedi u specifičnim kliničkim situacijama i sveukupni onkološki benefit. Osnovni ciljevi ove doktorske disertacije su bili: da se objektivizira procena veličine ART u tumorskom tkivu pluća i limfnih čvorova; da se proceni povezanost površine ART sa veličinom tumora na postoperativnom hirurškom materijalu posle neoadjuvantne terapije; da se analizira i proceni povezanost histomorfoloških parametara kod tumorske regresije indukovane neoadjuvantnom terapijom i spontane tumorske regresije u tumorima pluća i limfnih čvorova na postoperativnom hirurškom materijalu i u zavisnosti od histološkog tipa karcinoma; da se proceni povezanost kliničkog odgovora na neoadjuvantnu terapiju prema kriterijumima Svetske Zdravstvene Organizacije i histoloških parametara u tumorima pluća i limfnim čvorovima na postoperativnom hirurškom materijalu nakon neoadjuvantne terapije; da se proceni povezanost patološkog ypTN sa kliničkim ycTN stadijumom bolesti i stepena tumorske regresije indukovane neoadjuvantnom terapijom i patološkog ypTN i da se proceni povezanosti između kliničke i patološke zahvaćenosti N2 limfnih čvorova posle neoadjuvantne terapije. Merenje ukupne veličine očuvanih ART je najznačajniji objektivni parametar u proceni stepena tumorske regresije. Veličina rezidualnog tumora nije u korelaciji sa veličinom tumora posle neoadjuvantne terapije. Postoji signifikantna razlika u patohistološkoj slici tumorske regresije indukovane neoadjuvantnom terapijom i spontane tumorske regresije. Ne postoji signifikantna razlika između histološkog tipa tumora i histološke slike tumorske regresije. Ne postoji signifikantna povezanost između kliničkog odgovora i stepena tumorske regresije nakon neoadjuvantne terapije. Ne postoji korelacija između kliničkog i patološkog stadijuma bolesti posle neoadjuvantne terapije. Ne postoji korelacija između stepena tumorske regresije indukovane neoadjuvantnom terapijom i ypTN stadijuma bolesti. Ne postoji korelacija između kliničke i patološke zahvaćenosti N2 limfnih čvorova posle neoadjuvantne terapije. Stepen regresije tumora i merenje ART posle neoadjuvantne terapije određen histopatološkom analizom reseciranog tumora je najobjektivniji kriterijum za procenu hemioterapijskog odgovora i predviđanja ishoda lečenja pacijenata.
Lung cancers are the most common cause of morbidity and mortality from malignant tumors in the World. The neodjuvant therapy in patients with locally advanced (IIIA-IIIB) lung cancer and affected N2 lymph nodes is one of the modes of multimodal treatment of patients with non-small cell lung cancer (NSCLC) in order to improve the outcome of their treatment. This involves converting patients from a higher to a lower stage of the disease - "downstaging". There has been no significant connection between some forms of tumor response and types of therapy. Given the importance of complete pathological responses and tumor regression in the prediction of treatment outcomes, finding this relationship is of importance for the design of future neoadjuvant trails. In determining the histological tumor regression is very important measurement of area of residual tumor (ART). As the size of the tumor is one of the prognostic factors in patients with NSCLC who did not receive neoadjuvant therapy so the measurement of ART, as opposed to the macroscopic size of the tumor, one of the prognostic factors in patients with NSCLC, who had received neoadjuvant therapy. The ultimate goal of neoadjuvant therapy should be resectability and "downstaging" that could provide overall oncology benefit in specific clinical situations. The main objectives of this thesis were: to objectively estimate the size of ART in tumor tissue of lung and lymph nodes; to estimate the relation between the surface of ART with the size of the tumor on postoperative surgical material after neoadjuvant therapy; to analyze and estimate the relation between histomorphological parameters in tumor regression induced by neoadjuvant therapy and spontaneous tumor regression in tumors of the lung and lymph nodes in the postoperative surgical material and depending on the histological type of cancer; to estimate the relation between clinical response to neoadjuvant therapy according to criteria of the World Health Organization and histological parameters in lung tumors and lymph nodes in the postoperative surgical material after neoadjuvant therapy; to estimate the correlation of the pathological ypTN with clinical ycTN stage of the disease and the degree of tumor regression induced by neoadjuvant therapy and pathological ypTN and estimation of the relation between clinical and pathological involvement of N2 lymph nodes after neoadjuvant therapy. Measurement of the total size of the preserved ART is the most important objective parameter in the assessment of the grade of tumor regression. Size of residual tumor did not correlate with the size of the tumor after neoadjuvant therapy. There was a significant difference in the histological picture of tumor regression induced by neoadjuvant therapy and spontaneous tumor regression. There was no significant difference between the histologic type of tumor and histological tumor regression. There is no significant correlation between clinical response and the grade of tumor regression after neoadjuvant therapy. There is no correlation between clinical and pathological staging of the disease after neoadjuvant therapy. There is no correlation between the grade of tumor regression induced by neoadjuvant therapy and ypTN stage of the disease. There is no correlation between the clinical and the pathological involvement of the N2 lymph nodes to neoadjuvant therapy. The grade of tumor regression and measurement ART after neoadjuvant therapy determined by histopathological analysis of the resected tumor is the most objective criterion for evaluation of chemotherapeutic response and prediction of treatment outcome in patients.

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Van, der Velde Gabrielle. "Identifying the optimal treatment among common non-surgical neck pain treatments." 2008. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742546&T=F.

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Colle, Eduardo Boni. "Non-surgical treatment of peri-implantitis: a literature review." Master's thesis, 2019. http://hdl.handle.net/10284/9041.

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Objective: To evaluate the effectiveness of non-surgical treatments of peri-implantitis protocols. Methods: This review was conducted through a systematic search in the PubMed database. Human studies reporting non-surgical treatment of peri-implantitis with 3 or more months of follow up published in English language were evaluated. A review was performed to evaluate the effectiveness of the different protocols employed in the included investigations. Results: Ten articles were obtained and assessed, comparing the outcomes of the technique used as treatment of peri-implantitis. The clinical parameter assessed were probing pocket depth (PD), bleeding on probing (BoP), suppuration on probing (SoP) and plaque index (PI). Conclusions: Promising results were published recently regarding the effectiveness of non-surgical treatment of peri-implantitis. Further studies are required to make it possible to support one treatment technique to be the gold-standard against peri-implantitis.

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Montemarano, Michael Anthony. "The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis." Thesis, 2015. https://hdl.handle.net/2144/16017.

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This thesis presents a literature review of the diagnosis and treatment of lumbar spinal stenosis (LSS), including a brief description of the patient history and non-surgical options while focusing mainly on the current array of surgical techniques. LSS is defined as a narrowing of any part of the lumbar spinal canal. This narrowing places excessive pressure on both the spinal cord and peripheral nerves resulting in pain, numbness and weakness in the lower extremities. LSS has a large spectrum of potential treatment options since the disease itself has a wide range of severities. An extensive physical exam, using the appropriate clinical surveys, physical manipulations, and imaging studies, is of paramount importance in the successful diagnosis. Currently, conservative treatment, while an important first step in managing LSS, seems to be limited to a first line of defense, lasting only a short period of time. Physical therapy results appear to be beneficial for only six months to a year, and despite their increased usage in recent years, management through the use of non-steroidal anti-inflammatory drugs, opiates, and corticosteroid injections seem to provide very little benefit. Surgical treatment for LSS ultimately appears to be the most effective method in reducing pain and disability for the patient who fits the clinical and radiological findings indicative of LSS. Although current surgical options available are numerous, including different types of fusion, bone grafts, and innovative joint replacements, the most promising procedures appear to be minimally invasive lumbar disk replacement surgery and dynamic stabilization. These procedures offer the benefits of a minimally invasive surgical approach, while reducing stenosis though hardware that not only reduces pain but also allows patients to maintain spinal flexibility and natural functional motion.

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HUANG, LIANG-GIE, and 黃良吉. "The Effect on HbA1c in Diabetes Mellitus Patients Receiving Periodontal Non-surgical Treatment." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/45271272178746780937.

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碩士
東海大學
工業工程與經營資訊學系
105
The prevalence of diabetes is about 10% in Taiwan. There are seven complications derivatived from diabetes mellitus that have had causing the raise of the health insurance costs. Periodontal disease is one of the common diseases of the oral environment. According to recent studies, non-surgical periodontal treatment can help stabilize glycated hemoglobin (HbA1c)；however, there are rare related researches in Taiwan. The study data of this article was obtained from a medical center in central Taiwan. Of total 267 patients who has diabetes were asked to participate in the study, 89 patients receive full mouth non-surgical periodontal treatment as the experimental group, and the other 178 patients, not receiving periodontal treatment, were as the control group. The data of HbA1c was collected before and after periodontal treatment interval for six months in the experimental group, and for the control group, two data of HbA1c were recorded interval for six months. Patients were divided into four groups according to their age with the method of Mann-Whitney U test, which were 50 years old and under, 50-59 years old, 60-69 years old, and 70 years old and over, then separated with gender. We discovered that the data of male age under 50 experiment group had declined (P=0.013) after treatment with statistically significance. Other male groups, age 50-59 (P=0.340), age 60-69 (P=0.419), age 70 and above (P=0.226), and all the female groups, age 50 and under (P=0.434), age 50-59 (P=0.335), age 60-69 (P=0.308), age 70 and over (P=0.480), failed to show any statistically significance. According to the research, we recommend National Health Insurance Administration, Ministry of Health and Welfare promotes screening and treatment of periodontitis of male aging 50 and under. For other patients, we still need large-scale randomized clinical trials (RCTs) to ensure the effect of periodontal treatment on diabetic patients’ glycated hemoglobin.

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Soares, Ana Raquel Antunes. "Infecções odontogénicas." Master's thesis, 2016. http://hdl.handle.net/10284/5603.

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Introdução: As infecções odontogénicas constituem uma das patologias mais prevalentes e o principal motivo para a procura de cuidados médico-dentários a nível mundial. Todos os Médicos Dentistas deverão mostrar-se aptos a realizar um rápido diagnóstico bem como decidir de forma eficaz, ponderada e devidamente fundamentada qual o tratamento a aplicar a cada caso tendo consciência que a progressão de uma infecção odontogénica é, muitas vezes, imprevisível e um tratamento tardio ou incorrecto poderá acarretar complicações que implicam risco de vida para o paciente ao comprometer os espaços faciais profundos da cabeça e pescoço. Objectivo: Esta dissertação pretende, recorrendo à literatura existente, auxiliar o Médico Dentista no diagnóstico de uma infecção odontogénica e, essencialmente, evidenciar qual o tratamento preconizado ou considerado mais eficaz para este tipo de infecções orais. Materiais e métodos: Para a execução desta revisão da literatura, foi desenvolvida uma pesquisa, entre Janeiro e Junho de 2016, recorrendo à Biblioteca Ricardo Reis da Universidade Fernando Pessoa e à Biblioteca da Faculdade de Medicina Dentária da Universidade do Porto, ao portal “DGS” e às bases de dados electrónicas: PUBMED, SCIENCEDIRECT e Repositório Institucional da Universidade de Barcelona utilizando, para esse fim, as “palavras-chave” estabelecidas. Em suma, na realização da presente dissertação, foram consultadas três obras literárias e 23 artigos científicos. Conclusão: Segundo a literatura analisada, não existe consenso absoluto sobre qual o antibiótico que deverá ser prescrito no tratamento de infecções odontogénicas. A amoxicilina continua a ser referenciada como primeira linha de tratamento e, a necessidade e as vantagens da associação desta ao ácido clavulânico, são evidenciadas por diversos autores. A clindamicina é o antibiótico que se apresenta como segunda linha de tratamento, em casos de alergia aos beta-lactâmicos.
Introduction: Odontogenic infections are one of the most prevalent pathologies and the main reason for seeking medical and dental care worldwide. All Dentists should be able to perform a quick diagnosis and decide in an effective, thoughtful and justifiable way which treatment have to apply in each case, being aware that the progression of an odontogenic infection is often unpredictable and a late or incorrect treatment could provoke life risking complications for the patient when compromising deep facial spaces of the head and neck. Objective: This dissertation intends, using existing literature, to assist the Dentist in the diagnosis of an odontogenic infection and, essentially, to find evidence of which is the most recommended treatment or which one is considered the most effective for this type of oral infections. Materials and methods: For the execution of this literature review, a survey was carried out between January and June of 2016, using the Library Ricardo Reis of Fernando Pessoa University and the Library from the Dentistry´s Faculty of the University of Porto, the portal "DGS" and the electronic databases: PUBMED, SCIENCEDIRECT and Institutional Repository of the University of Barcelona using, for this purpose, the keywords established. In sum, in the realization of the present dissertation were queried three literary works and 23 scientific articles. Conclusion: According to the literature review, there is no absolute consensus on which antibiotic should be prescribed in the treatment of odontogenic infections. Amoxicillin is still referred as the first-line treatment and, the necessity and the advantages from the association with clavulanic acid are evidenced by several authors. Clindamycin is presented as the second-line treatment in such cases as allergy to beta-lactams.

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Chiu, Yuan-Ting, and 邱湲婷. "Smoking on Periodontal Status and Oral Health-related Quality of Life after Non-surgical Periodontal Treatment." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/43378457285706498312.

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碩士
高雄醫學大學
口腔衛生學系碩士在職專班
105
Objectives: To investigate the influence of outcomes of non-surgical periodontal treatment and oral health-related quality of life related to risk for smoking continuously. Methods: Prospective study. A total of 150 patients (including 47 smokers and 96 non-smokers) with chronic periodontitis were treated in Tainan Municipal Hospital Dentistry Department from February 1, 2016 to January 31, 2017. Clinical periodontal examinations(PPD,BOP) were performed at baseline (before treatment), one month (after treatment), and three months (after treatment).The patients fill in the first questionnaire (first measurement of adult oral health questionnaire) at baseline, covering basic information, smoking behavior, oral health behavior, oral health attitude, oral health knowledge, oral care and quality of life.One month after treatment ,they fill in the second questionnaire (second measurement of adult oral health questionnaire), covering oral health behavior.And three months after treatment ,they fill in the third questionnaire (third measurement of adult oral health questionnaire), covering oral care and quality of life. Finally, comparing with the difference of PPD, BOP and OHIP before and after treatment by independent t-test of SPSS statistical system and Linear regression of Generalized Estimating Equation Results: The results showed that the average PPD (± SD) was 3.02 mm (± 0.47) in the smoking group and 2.84 mm (± 0.45) in the nonsmoking group one month after treatment. The average PPD was 2.95 mm (± 0.52) in the smoking group and 2.73 mm (± 0.38) in the non-smoking group three months after treatment. There were significant differences between the two groups (P = 0.032, 0.007). The depth of the periodontal pocket decreasing was 0.48 mm (± 0.43) in the smoking group and 0.36 mm (± 0.28) in the non-smoking group over anterior region of maxilla. There was a statistically significant difference (P-value = 0.036) between these two groups too. Bleeding on probing(Bop) index decreasing 0.12 (±0.11) surface in the smoking group and 0.18 (±0.13) surface in the non-smoking group, with significant difference (P-value = 0.017). The average Oral health-related quality of life decreasing 3.16 points(±8.74) in the smoking group,with significant differences(P-value =0.004) and decreasing 4.24 points(±7.03) in the non-smoking group after treatment, with significant differences (P-value =<0.001). But there were no significant differences between the two groups (P-value =0.450). The level of psychological pain (in quality of life classification) improved 0.07 points (± 2.59) in the smoking group and 0.86 points (± 1.89) in the non-smoking group after periodontal treatment. There were significant differences between the two groups (P- value = 0.022) Conclusions: Smoking status has influence on the improvement of PPD, BOP, and quality of life in patients after taking NSPT. The periodontal disease index (PPD、BOP) will improve after treatment in smoking group, but the level of improvement is less than non-smoking group. Suggest that smokers can quit smoking temporarily during treatment to achieve better results. The results found that the periodontal pocket depth, gingival bleeding index and the improvement of oral health-related quality of life are positive correlation. The quality of life of Smokers and non-smokers will improve after NSPT both, representing patients which having periodontal disease with or without smoking are recommended to accept NSPT, in order to improve the oral health-related quality of life.

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Bompard, Xavier. "Enamel matrix derivative in the treatment of peri-implant diseases - a systematic review." Master's thesis, 2020. http://hdl.handle.net/10284/9386.

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Objective: To evaluate the benefit in terms of clinical, histological and radiographic outcomes of the adjunctive use of enamel matrix derivative (Emdogain® ; Straumann, Basel, Switzerland) on the non-surgical and surgical treatment of peri-implant diseases. Methods: A systematic literature search comprised three databases: PubMed, Scopus and Cochrane. Eligible studies were selected based on the inclusion criteria. Results: Seven studies were selected for data extraction. Two randomized clinical trials using Emdogain® as an adjuvant for non-surgical treatment of peri-implant mucositis; tree cohort studies and and two randomized clinical trials using Emdogain® as an adjuvant for surgical treatment of peri-implantitis. A reduction of the mean bleeding on probing (76.6%), probing depth (3.5mm), P. gingivalis counts and mean marginal bone level gain of 2,38±0.92mm was observed. Conclusions: Emdogain® has a positive effect on clinical and microbiological outcome of non-surgical treatment of peri-implant mucositis. Combined with grafting materials, it seems to improve bone fill after surgical treatment of peri-implantitis. More studies are necessary to determine the effects of Emdogain® alone in the clinical outcome of peri-implantitis treatment.

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Chen, Ya-Wen, and 陳雅雯. "The Adjunctive Effect of Multiple Antimicrobial Photodynamic Therapy in The Non-surgical Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61656867662252873517.

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碩士
國立臺灣大學
公共衛生碩士學位學程
103
Periodontitis is the most common chronic oral disease. Periodontitis involves the periodontal tissue including gingiva, alveolar bone and periodontal ligament. Gingivitis and chronic periodontitis are frequently in clinical examination. The symptom and sign of gingivitis mostly confined to gingival tissue, gingival redness, swelling, pain, and gingival bleeding while brushing. Periodontitis the symptoms and signs of gingivitis, but the alveolar bone beneath the gingiva and periodontal ligament. There are 500-600 species of bacteria in the oral environment, existing on the tooth surface, mucosa and saliva. The bacteria species alter in different oral ecological environments. Different bacteria together a biofilm. The bacteria extracted from the periodontal pockets were mainly Gram''s negative anaerobic bacteria. Based on current literture, the periodontal disease pathogenic mechanism is caused by toxins released by the pathogenic bacteria. The toxins would evoke the gingival tissue and the host would the immune response to react. Cytokines and histodialysis enzymes are released during the process, causing alveolar bone and tissue destruction. The degree and extent of destruction depends on the defensive system function, leukocyte ability, genetic variances or environment differences, for example, inadequate oral hygiene, smoking habits, and systemic condition factors. There are 1 hundred million bacteria in 1 milligram of plaque. Inadequate oral hygiene environment increases the amount of bacteria accumulated on the tooth surface or gingival sulcus by 2 to 10 folds. Periodontal disease treatment focuses on supragingival and subgingival plaque and calculus removal. This experiment examined the adjunctive effect of photodynamic therapy on nonsurgically-treated chronic periodontitis patients. During the course of treatment, periodontal curette was applied to remove the subgingival calculus and inflammation tissue. Correct and effective oral hygiene care instructions and tooth-brushing techniques were given to the patients to reduce the amount of plaque. Clinical trial 36 patients aged between 35 to 70 years old with chronic periodontitis. At least 16 teeth in the oral cavity. Incisor, canine, or premolar teeth in the same arch on different sides were selected in pairs, and there were at least two sites with periodontal probing depth than 5mm, periodontal attachment level than 4mm as the experimental group and control group. Patients not under antibiotic medication or periodontal treatment in six month. The course of this clinical trial was arranged into two steps. In the first step, participants were all treated with scaling and root planing as full mouth periodontal nonsurgical treatment. Split mouth, the participants were into two groups experimental group then photodynamic therapy as adjunctive treatment for the nonsurgically-treated chronic periodontitis patients. And the control group injection saline as placebo for adjunctive treatment. After the photodynamic therapy and nonsurgical periodontal treatment, periodontal pocket depth, tooth mobility, and keratinized degree of gingiva were. Also, the amount of periodontal pathogenic bacteria and the amount of sulfide compound in the oral cavity were .

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Tsai, Shin-Jiun, and 蔡欣君. "The effectiveness of non-surgical treatment periodontal intervention on periodontal status and oral care behavior of type II diabetic patients: A clinical-based pilot study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/qwxcq7.

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碩士
高雄醫學大學
口腔衛生學研究所
102
Background: Awareness of oral health care is insufficient for diabetes patients to realize their disease impact on oral disease and its complications, and thus failed to take appropriate preventive oral health behaviors. Objective: To evaluate the effectiveness of non-surgical periodontal therapy and oral hygiene instruction on periodontal status, oral health knowledge, attitude and behaviors among type II diabetic patients. Method: A quasi-experimental experimental design was used. Type II diabetic patients were recruited from the Division of Endocrinology and Metabolism in Kaohsiung Medical University Hospital, Taiwan. Inclusion criteria of participants were having type II diabetes, aged 45-65, having at least five teeth in oral cavity, having gingival bleeding when screening, and probing pocket depth (PPD)≧5mm. Diabetic patients who had periodontal treatment within six months, regular used antibiotic and bisphosphonates and had seriously harmful diseases were excluded. Non-surgical periodontal therapy will be used for experimental group, the control group will be offered no receive clinical oral health education. A total of 28 patients finished the study. Wilcoxon rank sum test and Fisher’s exact test, McNemar exact test/marginal homogeneity test analyzed the differences in oral self-care behavior knowledge attitudes between pretest and post-test. Wilcoxon sign rank test/two sample t-test/Repeated-measures ANOVA analyzed the differences in periodontal status between pretest and posttest. Result: There was significant improvement of the periodontal index among experimental group after non-surgical periodontal therapy intervention. Clinical oral hygiene instruction increased the frequency of brushing method; however, oral health knowledge and attitude had no significant increase at post-test. Conclusion: The oral health knowledge and attitude had no significant change after oral hygiene instruction. Further periodontal-related health education should provide for diabetes patients to increase their oral health care behaviors.

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Rodrigues, Maria João Carvalho. "Jateamento com eritritol na terapia de manutenção periodontal." Master's thesis, 2019. http://hdl.handle.net/10316/89607.

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Trabalho Final do Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina
Introdução: O tratamento periodontal de manutenção é essencial na prevenção ou redução da progressão da doença periodontal. A terapia não cirúrgica convencional consiste na instrumentação manual com curetas e o uso de aparelhos de ultrassons. O uso regular destas técnicas induz desgaste dentário e dano tecidular. Como alternativa, desenvolveram-se os jatos periodontais associados a um pó abrasivo. O pó de glicina mostrou resultados satisfatórios, com diminuição da perda do tecido dentário e sem diferenças significativas de eficácia de remoção de placa bacteriana. Contudo, a eficácia do novo pó de eritritol e a sua eventual superioridade relativamente às restantes terapias, ainda não está esclarecida.Objetivo: O objetivo deste trabalho consiste na realização de uma revisão da literatura para avaliar a eficácia do jato periodontal com o pó de eritritol no tratamento periodontal de manutenção, em termos da melhoria do dano tecidular, dos principais parâmetros clínicos periodontais, microbiológicos e parâmetros centrados no paciente, comparativamente às técnicas de desbridamento mecânico convencionais e utilização de outos pós.Materiais e Métodos: Após a formulação de uma questão PICO, juntamente com os critérios de inclusão e exclusão preestabelecidos, foi realizada uma pesquisa de artigos relevantes nas bases de dados Medline (Pubmed), Cochrane Library, Embase e ScienceDirect, usando-se como filtros publicações em inglês, português e espanhol sem limite cronológico nem restrições sobre o tipo de estudo.Resultados: De um conjunto inicial de 68 artigos, foram selecionados 10: 3 in vitro, 1 ex vivo, 3 RCT, 3 revisões sistemáticas das quais uma com meta-análise.Conclusão: Dentro das limitações deste estudo de revisão, pode ser concluído que o uso do jato periodontal com pó de eritritol apresenta uma eficácia semelhante à terapia convencional com curetas e ultrassons, quer na melhoria dos parâmetros clínicos, quer ao nível microbiológico. A vantagem da sua utilização parece relacionar-se com o facto de causar menor dano tecidular e maior conforto do paciente. No entanto, relativamente ao jateamento com pó de glicina, os resultados apresentaram-se similares em todos os parâmetros analisados.
Background: Supportive periodontal therapy is essential in preventing or reducing the progression of periodontal disease. Conventional non-surgical therapy consists of manual scaling with curettes and ultrasonic devices. The regular use of these techniques induces hard and soft tissue damage. Air-polishing devices associated with an abrasive powder were developed as an alternative. Glycine powder showed satisfactory results, with reduction of tissue damage and similar efficacy in removing biofilm. However, the efficacy of the new powder erythitrol and its superiority in relation to other therapies is still unclear.Objective: The objective of this literature review is to evaluate the efficacy of air-polishing device with erythritol powder in supportive periodontal therapy, in terms of the improvement of the main periodontal clinical parameters, tecidular damage, microbiological and patient centered outcomes, and compare it to conventional mechanical debridement and the use of other powders. Materials and Methods: After establishing a focused question, as well as inclusion and exclusion criteria, a literature research was performed in Medline (Pubmed), Cochrane Library Embase and ScienceDirect, using as filters publications in English, Portuguese or Spanish and without chronological limitation, nor restriction regarding the type of publication..Results: A total of 68 articles were obtained from which 10 were selected: 3 in vitro, 1 ex vivo, 3 RCT and 3 systematic reviews one of them being a meta-analysis.Conclusion: Within the limitations of this review, it may be conclude that the use of air-polishing with erythritol powder shows a similar efficacy to conventional therapy in improving clinical or microbiological parameters. The advantage of its use seems to be related to the fact that it leads to less tissue damage and greater patient comfort. However, when compared with glycine powder air polishing, the results were similar in all parameters analysed.

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Dissertations / Theses on the topic 'Non-surgical treatment'

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