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Dissertations / Theses on the topic 'P 80'

Author: Grafiati

Published: 4 September 2021

Last updated: 29 July 2025

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1

Nicoletti, Caroline Deckmann. "Desenvolvimento de géis de papaína a 4,0% (p/p) com polissorbato 80 como agente solubilizante." Niterói, 2017. https://app.uff.br/riuff/handle/1/3061.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-03-17T17:34:41Z No. of bitstreams: 1 Nicoletti, Caroline Deckmann [Dissertação, 2015].pdf: 2492191 bytes, checksum: 2cc1df517b27092f16baf567910a3c1a (MD5)<br>Made available in DSpace on 2017-03-17T17:34:41Z (GMT). No. of bitstreams: 1 Nicoletti, Caroline Deckmann [Dissertação, 2015].pdf: 2492191 bytes, checksum: 2cc1df517b27092f16baf567910a3c1a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A papaína é uma enzima proteolítica utilizada no tratamento de feridas. É parcialmente solúvel em água

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2

Merouah, Aiman <1997&gt. "Classificazione e analisi di 80 business model pattern." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/20199.

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La tesi ha l'obiettivo di classificare e analizzare 80 business model pattern. Il primo capitolo affronta l'innovazione strategica, approfondendo il suo ruolo metodologico nella creazione e formulazione di nuovi modelli di business, e nella loro rappresentazione tramite il canvas composto da dieci building blocks. Inoltre, tale capitolo dà una definizione di business model pattern. Il secondo capitolo illustra la metodologia di ricerca, mentre il terzo descrive il framework utilizzato per l'analisi dei pattern. Il quarto capitolo contiene tutti gli 80 business model pattern, esplicati tramite

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3

Difino, Davide Marco <1993&gt. "The "80 Euro" policy: a theoretical and empirical evaluation." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/13831.

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This work will examine, from a theoretical and empirical perspective, the policy adopted by the Italian Government on April 24, 2014 and known as the "Eighty Euro Tax Rebate". It provided for an automatic tax rebate of € 80 for employees, freelancers, independent contractors and project-based workers with gross incomes between € 8,125 and euro 26,000. This policy affected over 10 million workers and entailed a transfer of euro € 5.823 billion, equivalent to 0.4 percent of the Italian GDP. The first part will present a general overview of the policy, with a focus on the empirical analysis by

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4

Belache, Boukhalfa. "Propriétés électriques de l'InP in type p." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59298.

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Indium Phosphide epitactic layers grown by MOCVD and lightly doped with Zn and Mg (p-type) have been studied by Hall effect measurements and secondary ion mass spectroscopy (SIMS). The Zn-doped samples showed a uniform distribution of the acceptor concentration as a function of depth. Mg doped samples showed strong Mg concentration gradients, with substantial diffusion into the substrate. An electrical transport model has been developed for each of the previous cases. These models provided excellent agreement with experiment. The uniformly Zn-doped samples have been used for a detailed study o

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5

Van, Zyl Johannes Jacobus. "Two-nucleon transfer in the 58Ni(p;3He)56Co reaction at incident energies of 80, 100 and 120 MeV." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71798.

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6

TONINELLI, Daniele (ORCID:0000-0002-3158-1982). "Survey techniques : an application to prices data for the computation of price indexes." Doctoral thesis, Università degli studi di Bergamo, 2009. http://hdl.handle.net/10446/80.

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7

Reid, Fergus. "Varieties for modules of small dimension." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203509.

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This thesis focuses on the subject of varieties for modules for elementary abelian p-groups. Given a homogeneous polynomial over an algebraically closed field of char- acteristic 2 we will give constructions for modules of small dimension having that polynomial as variety. This is similar to an earlier construction given by Jon Carlson but our modules will in general be of considerably smaller dimension. We also investigate the connection between the variety of a module and its Loewy length. We show that working over an algebraically closed field of characteristic 2 with modules of Loewy lengt

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8

Castellà, Cabello Francisco. "On the p-adic variation of Heegner points." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117141.

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In this thesis we study the so-called ``big Heegner points'' introduced and first studied by Ben Howard. By construction these are global cohomology classes, with values in the Galois representation associated to a twisted Hida family, interpolating in weight 2 the twisted Kummer images of CM points.In the first part, we relate the higher weight specializations of the big Heegner point of conductor one to the p-adic etale Abel-Jacobi images of Heegner cycles. This is based on a new p-adic limit formula of Gross-Zagier type obtained in the recent work [BDP] of Bertolini-Darmon-Prasanna, a form

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9

Zhao, Jin 1975. "Investigations of the biocatalytic activity of human P450 2D6." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111940.

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The cytochrome P450 enzymes (CYPs) are very attractive biocatalysts because of their ability to regio- and stereo-selectively catalyze the insertion of a single atom of molecular oxygen into inactivated C-H bonds. There are many drawbacks, however, limiting the use of these enzymes in organic synthesis, including the need for expensive cofactors, low stability, and low tolerance to organic solvents. The goal of this thesis was to overcome some of these drawbacks for human CYP2D6. This isoform was selected because of its broad substrate promiscuity and high importance in drug metabolism.<br>We

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10

Nicole, Marc-Hubert. "The supersingular locus of Hilbert modular surfaces modulo p /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33431.

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We try generalizing the description of the supersingular locus of the moduli space of polarized abelian surfaces with real multiplication by OL (see [1]) in the case where p is inert in OL . We present evidence to support a conjectural mass formula for superspecial points and a counting formula for such points, generalizing a classical result of Deuring on supersingular elliptic curves. This result would provide a geometric interpretation of a special case of the Jacquet-Langlands correspondence. The remaining portion of the thesis is preliminary work with a view toward arithmetical applicatio

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11

Yang, Hung-Pao 1980. "A study of P-type zinc oxide thin films /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99550.

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In the past decade, p-type ZnO material has been investigated extensively. Its properties offer the potential for broad applications including the development of ultraviolet light emitting devices. Although n-type ZnO material is well known and studied for decades, the fabrication method and properties of p-type ZnO material are still to date not clearly understood.<br>In this report, reproducible p-type ZnO thin films sputtered on glass substrates are reported. On the same substrate, p-type ZnO film is local and surrounded by n-type ZnO regions. The thickness of the films is typically three m

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12

Polvani, Carlomaria. "Ion transport and charge transfer by P-type ATPases." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74298.

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Using fluorescein isothiocyanate-dextran filled inside-out vesicles derived from 4$ sp prime$,4-diisothiocyano-2$ sp prime$,2-disulfonic stilbene treated human red blood cells, we investigated the mechanistic basis for the decrease in the Na:Rb(K) stoichiometry of the Na,K-ATPase observed when the cytoplasmic sodium concentration is decreased below 0.4 mM (Blostein, R., 1983, J. Biol. Chem. 258: 12228-12232). First, we considered the possibility of H$ sp{+}$ replacing Na$ sp{+}$ and/or K$ sp{+}$. It was found that in the absence of Na$ sp{+}$, a decrease in pH from 7.4 to 6.0 effected an incre

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13

Park, Sunyoung. "Studies of metal contacts on p-type copper indium diselenide." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103479.

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For characterization of devices on copper indium diselenide, CuInSe2, it is important to obtain metal contacts with low contact resistance. Samples from p-type CuInSe2 ingots grown by the Bridgman method were prepared for contact experiments. Metal contacts of Ag, Au, Al, Ni, Pt, Se, or Te were deposited on the CuInSe2 by vacuum evaporation for contact resistance measurements. Effects on polishing and etching the CuInSe2 surfaces on the contact resistance were studied. It was observed that the contact resistance can be reduced by etching.<br>Pour la caractérisation des dispositifs sur disélé

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14

Kwan, Tony 1972. "Structural and functional analysis of the mouse Mdr3 P-glycoprotein." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38069.

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Multidrug resistance in certain tumours in vivo and in cultured cells in vitro is caused by the overexpression of P-glycoprotein. Pgps are encoded by a small family of three genes in rodents (mdr1, mdr2, mdr3 ) and two in humans (MDR1, MDR2), and belong to the larger superfamily of ABC transporters, characterized by their ability to transport various substrates at the expense of ATP. Pgps are comprised of 12 transmembrane (TM) domains, some of which are involved in the binding of these drugs, and two intracellular nucleotide-binding (NB) domains that catalyze ATP hydrolysis. Communication occu

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15

Cayrol, Romain. "Study of class I and class II P-glycoprotein chimeras." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19436.

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The Multidrug drug resistance (MDR) phenotype is a major limitation to chemotherapy. The MDR phenotype arises when class I P-glycoproteins (P-gps) are overexpressed in cultured cells in vitro and in tumor cells in vivo. P-gps are encoded in rodents by three genes: mdr1, mdr2 and mdr3. Class I P-gps (Mdrl, Mdr3) confer drug resistance upon transfection in non-resistant cells and act as ATP dependent drug efflux pumps, class II P-gps (Mdr2) do not convey MDR but act as lipid flippases in the canalicular membranes of hepatocytes. P-gps are composed of twelve transmembrane domains and two nucleoti

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16

Rousseau, Marc-Etienne. "Studies of P-glycoprotein intracellular domains by cysteine scanning mutagenesis." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30738.

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Interactions between the various intracellular loops and nucleotide binding domains (NBDs) of P-glycoprotein (P-gp), and the extent to which they contribute to protein structure and transport mechanism are widely unknown. Analogy to bacterial members of the ABC transporter family suggests that the nucleotide binding domains interact with a specific site on an intracellular loop and with each other, as a cooperative dimer, in order to energize the transport functions. To investigate this hypothesis, we have used a cysteine scanning mutagenesis strategy on four potentially interacting regions of

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17

Nogueira, Dayanne Támela Soares. "Salinidade, temperatura e petróleo na resposta fisiológica de sementes de Poincianella pyramidalis (Tul.) L. P. Queiroz." Universidade Federal Rural do Semi-Árido, 2016. http://bdtd.ufersa.edu.br:80/tede/handle/tede/641.

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Submitted by Lara Oliveira (lara@ufersa.edu.br) on 2017-03-23T19:49:11Z No. of bitstreams: 1 DayanneTSN_DISSERT.pdf: 1338268 bytes, checksum: 2ceb62e733ae7b4bf23609d3ab99716a (MD5)<br>Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2017-04-13T14:44:45Z (GMT) No. of bitstreams: 1 DayanneTSN_DISSERT.pdf: 1338268 bytes, checksum: 2ceb62e733ae7b4bf23609d3ab99716a (MD5)<br>Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2017-04-13T14:44:54Z (GMT) No. of bitstreams: 1 DayanneTSN_DISSERT.pdf: 1338268 bytes, checksum: 2ceb62e733ae

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18

Wang, Guanhua 1970. "Genetic variation in P-glycoprotein in Haemonchus contortus following ivermectin selection." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79203.

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Resistance to ivermectin (IVM) in Haemonchus contortus has developed in many countries and its mechanism is still under investigation. P-glycoproteins (P-gp) are transmembrane proteins that can transport drugs out of cells. Researchers have found that there is polymorphism in a P-gp gene from H. contortus between IVM-selected and unselected worms. Three main P-gp polymorphs were identified, polymorph A was found to be related to IVM selection, while polymorphs B and X were associated with susceptibility. The purpose of this research is to investigate the genetic variations in P-glycopro

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19

Bellerive, Alain. "Investigation of semileptonic B meson decays to p-wave charm mesons." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34913.

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This thesis presents an investigation of semileptonic B meson decays with a narrow P-wave charm meson in the final state. The data sample consists of 3.29 x 106 BB¯ events collected with the CLEO II detector at the Cornell Electron-positron Storage Ring. The P-wave charm mesons are reconstructed in the chain of decays: D0J→D*+p- ,D*+→D0p+,D 0→K-p+ or D0→K-p+p 0 . Study of the decay B-→D*+p0&ell; -n&ell;&d1; reveals useful information about the deficit observed in inclusive charm semileptonic B decays and the effective couplings of the W boson to heavy quark mesons

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20

Rosati, Marzia. "A measurement of proton and pion induced P-wave charmonium hadroproduction." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39314.

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The production of charmonium states, $ chi sb1$ and $ chi sb2$, was measured at 300 GeV/c with $ pi sp+$, $ pi sp-$, and proton beams on a lithium target. The cross-sections were determined by analyzing the full data sample recorded, during the 1987-1988 running period, by experiment E705 at Fermilab. The $ chi$ mesons were detected through their radiative decay into J/$ psi$ $ gamma$ and the subsequent decay, $ psi to mu sp+ mu sp-$.<br>The measured cross-sections for the $ chi$ mesons and estimates of the cross section for direct production of J/$ psi$'s have been compared with measurements

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21

MacLellan, Kelly N. M. (Kelly Nadine Mary). "The effects of O,P'-dicofol on two generations of American kestrels /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68216.

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A two generation laboratory study was conducted on a captive population of American kestrels (Falco sparverius) to investigate the possible teratogenic effects of the pesticide Dicofol. Paired females were exposed to three levels of Dicofol. Integrity of the reproductive tract of the resulting embryos were examined. Viable eggs were hatched and these birds were permitted to breed the following year. Breeding performance for these birds was measured based on their ability to form pair bonds and exhibit normal behaviour in the presence of a mate. Clutch completion, fertility, hatchability and nu

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22

Zhong, Mei 1969. "Structure-function studies of the proprotein convertases : the Pro- and P-domains." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37603.

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The proprotein convertases (PCs) are involved in the activation of a wide variety of precursors via limited proteolysis at either single or paired basic residues, a crucial regulatory process in both normal and disease states. Seven members of this family were identified including furin, PC I, PC2, PC4, PACE4, PC5 and PC7. All of which exhibit a signal peptide, a prosegment, a catalytic domain, a P-domain and a specific C-terminal segment. The present work concentrated on the characterization of two structural elements, namely the prosegment and the P-domain, which are critical for enzymatic f

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23

Chan, Chi Lun. "Alp-CuInSe2 tunnel MIS Schottky diodes & surface properties of crystalline p-CuInSe2." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61911.

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24

Grand'Maison, Jérôme. "Determining the Zeta function of curves via p-adic cohomology and deformation theory." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18779.

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This thesis has two main parts: both of which aim at computing the Zeta function of some curves. The first part contains the theoretical and practical considerations to make K. Kedlaya's algorithm and some of its generalizations work. We review important properties of the Monsky-Washnitzer cohomology, the Weil conjectures and piece the bits together in order to provide an algorithm that would compute the Zeta function of a superelliptic curve, due to P. Gaudry and N. Gürel. In the second part, we present an algorithm to compute the Zeta function of a Cab curve using deformation theory. The gen

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25

Masdeu, Sabaté Marc. "CM cycles on varieties fibered over Shimura curves, and «p»-adic «L»-functions." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95183.

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Let f be a modular form of weight k ≥ 4 on a Shimura curve, let K be a quadratic imaginary field, and fix a rational prime p which is inert in K and di- vides the level of f. The goal of this thesis is to construct and study a collection of algebraic cycles on an appropriate Chow motive which encode data about the anticyclotomic p-adic L-function Lp(f,K,s) attached to f and K introduced by Bertolini-Darmon-Iovita-Spieß in [BDIS02]. In our setting, this function of a p-adic variable s vanishes in the critical range s = 1,...,k−1, and we study its derivative. After constructing this motive and t

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26

Ma, Weiya. "Substance P sensory fiber innervation of CNS target tissues in two experimental models." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40185.

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The aim of this thesis study was to investigate the substance P (SP)-immunoreactive (IR) sensory fiber innervation of CNS target tissues in two experimental models. In the first model, we examined the SP-IR boutons apposed to three functional types of dorsal horn neurons and their morphological interaction with calcitonin gene-related peptide (CGRP) and enkephalin (ENK) in the cat spinal cord, using a combination of intracellular electrophysiological recording and horseradish peroxidase injection with ultrastructural immunocytochemistry. In addition to SP-IR only boutons, we detected boutons c

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Godoy, Rosas Pablo. "Functional analysis of «Haemonchus contortus» P-glycoprotein-A and interaction with macrocyclic lactones." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97122.

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Macrocyclic lactone (ML) resistance has been described in the parasitic nematode, Haemonchus contortus. One of the mechanisms involved could be the over expression of P-glycoproteins (Pgps) which are ABC transporters. These proteins may influence the concentration of MLs that reach their target. In H. contortus one ABC transporter that is overexpressed in ML resistant parasites is Pgp-A (HcPgp-A). The goal of this project was the expression of HcPgp-A, in transfected LLC-PK1 cells, and to see the effect of ivermectin and moxidectin on inhibition of rhodamine 123 transport by the transfected ce

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Chandler, Catherine. "Spectroscopy of exotic f - p - g nuclei using projectile fragmentation and fusion evaporation reactions." Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/843034/.

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The structural properties of the very neutron deficient systems around N~Z~40 have been studied in two experiments performed at the GANIL and Legnaro laboratories. The fragmentation of a 60 MeV/u92 Mo beam on a natural nickel target at the GANIL Laboratory, France, produced exotic nuclei along the proton drip line in the mass 80 region. Isomeric decays have been observed for the first time in the N=Z+2 systems 74 36Kr, 80 39Y and 84 41Nb. The isomer in 74 Kr is interpreted as the hindered decay from an excited 0+ state, supporting the long-standing prediction of prolate/oblate shape coexistenc

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Al-Dhaher, Zainab. "Angiotensin II produces endothelial dysfunction by simultaneously activating eNOS and NAD(P)H oxidase." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112371.

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Blockade of the renin-angiotensin system lowers the rate of cardiovascular events in patients at risk for vascular disease and also improves endothelial function but the mechanism remains unclear. HUVECs were stimulated with Ang II (100 nM). Ang II produced a 2-fold increase in O2- production, which was measured by lucigenin-enhanced chemiluminescence. This increase was blocked by NAD(P)H oxidase inhibitor DPI, but not by eNOS inhibitor L-NAME. Ang II increased monocyte adhesion to ECs by 4.5-fold, and this increase was blocked by candesartan (AT1 receptor antagonist), DPI, L-NAME, wortmannin

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Liston, Peter. "Structure and function of the protein products encoded by the measles virus P cistron." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39946.

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The research work presented in this thesis involved an examination of the structure and function of the protein products of the measles virus (MV) P cistron. At least three protein products of the P cistron have been identified in MV infected cells. The largest of these is the P protein, which is translated in a canonical manner from genome faithful transcripts. The V protein is translated from a secondary population of edited mRNAs, and the C protein is generated via alternative translational initiation from both P- and V-specific mRNAs. Previous work in our laboratory had identified and char

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Carrier, Isabelle 1976 Dec 18. "Investigating the nucleotide-binding domains of Abcb1a (mouse P-glycoproteinMdr3) : a mutational analysis approach." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115678.

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ABC transporters consist of two transmembrane domains (TMDs) that form the transport channel and two cytosolic nucleotide-binding domains (NBDs) that energize transport via ATP binding and hydrolysis. Using site-directed mutagenesis, the role of highly conserved residues in the NBDs of Abcb1a was investigated.<br>In both NBDs of Abcb1a the A-loop aromatic residue is a tyrosine: Y397 in NBD1 and Y1040 in NBD2. Another tyrosine (618 in NBD1 and 1263 in NBD2) also appears to lie close to the ATP molecule. These four tyrosine residues were mutated to tryptophan and the effect of these substitution

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Asimakopulos, Anna. "P.D. James : a moral murder she wrote." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61066.

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This thesis places P. D. James's detective novels within the historical and critical framework of the detective genre, and explores her particular contributions to it. James's awareness of the implications of a police investigation, coupled with her strikingly bleak and moralistic representation of our contemporary world are two of the main reasons she has achieved such widespread critical acclaim. Her novels also have a didactic dimension that ranges from an assertion of morally-correct modes of behaviour in an age without religion, to the constant reminder that, although they provide enterta

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Wang, Ying 1958. "Identification and characterization of a novel mechanism of multidrug resistance in tumour cells." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35507.

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The development of multidrug resistance (MDR) in tumour cells to a wide range of anticancer drugs has become a major obstacle in the chemotherapeutic treatment of cancer. Molecular characterization of MDR tumour cells has led to the identification of several cell-based genetic alterations including the overexpression of a membrane protein, P-glycoprotein (P-gp). P-gp is a ATP dependent drug efflux pump and P-gp ATPase activity has been demonstrated to be essential in drug transport. In an effort to understand how P-gp ATPase activity is coupled to drug binding and transport, we examined the ef

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Andrade, Miguel Wanderley de. "Fontes e doses de N, P, K e métodos de enxertia na produção de mudas de umbuzeiro (Spondias tuberosa Arr. Cam.)." Universidade Federal Rural do Semi-Árido, 2010. http://bdtd.ufersa.edu.br:80/tede/handle/tede/148.

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Made available in DSpace on 2016-08-12T19:18:23Z (GMT). No. of bitstreams: 1 MiguelWA_TESE.pdf: 866144 bytes, checksum: bde15803e78a319bdc6626bd84a49d0a (MD5) Previous issue date: 2010-12-16<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The objective of this study was to determine the effect of sources and doses of NPK and to evaluate the propagation by grafting for the production of vigorous seedlings of umbu tree (Spondias tuberosa Arr Cam). The experiments were conducted in greenhouse in Sousa-PB. We adopted the randomized block design in 2 x 5 factorial scheme with fo

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Sohati, Philemon Hakainda. "Studies on the egg parasitoids of Lygus lineolaris (P. de B.) (Hemiptera:Miridae) in southwestern Quebec." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55677.

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Cridland, Ruth Anne. "Roles of substance P in the mediation or modulation of a nociceptive reflex in the rat." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75692.

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This thesis investigates the effects of substance P on a spinal nociceptive reflex in the rat. Intrathecal administration of substance P and other analogous peptides to the L5 vertebral level produced a dose-dependent decrease in reaction time to tail withdrawal from a noxious radiant heat source. Similar administration of VIP, galanin, CGRP, angiotensin II, somatostatin and TRH failed to mimic these effects of substance P. As substance P was found to equally decrease the reaction time in spinal transected rats, it is concluded that this facilitation occurs via a spinal mechanism alone.<br>Adm

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Flageole, Hélène. "Substance P increases in vitro lymphokine-activated-killer (LAK) cell cytotoxicity against fresh colorectal cancer cells." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56993.

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Gut associated lymphoid cells are modulated by gut hormones. We postulated that lymphokine-associated-killer (LAK) cell cytotoxicity of lymphocytes from the gut mucosa may be increased by substance P (SP).<br>Intestinal lamina propria mononuclear cells (LPMC) and colonic cancer cells were isolated from operative specimens by mechanical and enzymatic dissociation methods. Effector LAK cells were induced by culturing LPMC with 250 u/ml of recombinant interleukin-2 (IL-2). Substance P (10$ sp{-5}$M) was added to the culture. Targets consisted of fresh colon cancer cells, HT-29 and control cell li

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Sam, Hakeem. "Mechanism(s) of interleukin-12-induced protection against early murine blood-stage P. Chabaudi AS malaria." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35939.

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Previous studies suggest that IL-12, the potent Th1-inducing cytokine, IFN-gamma, TNF-alpha and nitric oxide (NO) contribute to resistance against blood-stage malaria. Early Th1 responses correlate with resistance, whereas predominantly Th2 responses are associated with susceptibility. In the present studies, the requirements for endogenous IL-12 and its role in host defense against blood-stage P. chabaudi AS malaria were investigated. Our results reveal, for the first time, significant differences in the kinetics of endogenous IL-12 p70 synthesis and splenic IL-12R beta1 and beta2 mRNA expres

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Shen, Baike 1972. "Slip frequency phase lock loop (PLL) for decoupled P-Q control of doubly-fed induction generator (DFIG)." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81568.

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The term "sensor-less" in power electronic drives refers to measurement of mechanical shaft position and/or speed from the currents and voltages of the electrical machine. This thesis presents innovative sensor-less means (a Slip Frequency Phase Lock Loop (PLL) and a gamma-delta Axes Aligner) for implementing decoupled P-Q control of a doubly-fed induction generator (DFIG) for wind-turbine application. Proofs of concepts are by digital simulations.<br>The accuracy of the Slip Frequency Phase Lock Loop in speed estimation is evaluated; the origin of a shortcoming (small phase lag) locate

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Zhang, Shan Hong. "Directed evolution of a pseudomonad p-cumate-2,3-dioxygenase for enhanced synthesis of an acid cis-diol." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82455.

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p-Cumate-2,3-dioxygenase (CDO) from Pseudomonas putida F1 converts p-cumate to cis-2,3-dihydroxy-2,3-dihydro-p-cumate, a potential useful acid cis-diol. To enhance the activity of CDO for the production of this acid cis-diol, the recombinant CDO expressed in Escherichia coli Top10 strain was evolved by directed evolution using the error-prone polymerase chain reaction (EP-PCR) method. The mutant library was screened in a 96-well format based on the enzyme's ability to transform colorless indole-2-carboxylate to the water-insoluble blue dye indigo. Screening of 300 colonies resulted in four var

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Liu, Hao Yuan 1961. "Genetic variation of a P-glycoprotein gene in unselected and ivermectin- and moxidectin-selected strains of Haemonchus contortus." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21597.

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Anthelmintics, antiparasitic agents, have been developed as a main weapon to control parasitic nematodes of domestic ruminants. Unfortunately, the intensive use of anthelmintics leads to the development of drug resistance in parasite populations. Anthelmintic resistance has compromised the control of nematode parasites and has become a major problem in many countries of the world. Resistance to the newest anthelmintics such as ivermectin (IVM) and related anthelmintics in Haemonchus contortus in sheep has been developing rapidly in recent years. The development of drug resistance is an evoluti

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Karwatsky, Joel Michael. "The biochemical and drug binding characteristics of two ABC transporters /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85925.

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Chemotherapy is used in the treatment of cancer. Unfortunately, drugs often fail due to multidrug resistance (MDR) caused by P-glycoprotein (P-gp1or ABCB1) and the multidrug resistance-associated protein (MRP1 or ABCC1). These proteins bind and transport drugs out of cancer cells, thereby conferring MDR.<br>The second chapter of this thesis addresses an unexplained phenomenon that accompanies P-gp1 expression, collaterally sensitive to verapamil. The collective results of this work demonstrated that treatment of cells that over-express P-gp1 with verapamil induces apoptosis. Furthermore

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Fallis, Brooks A. "Investigations into the role of substance P and the NK-1 receptor in an animal model of neuropathic pain." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78358.

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This study investigates the role of substance P and NK-1 receptors in an animal model of neuropathic pain. Unlike naive animals, innocuous peripheral stimulation of neuropathic animals was determined to cause heterosegmental inhibition in the tail-flick test as well as increased plasma extravasation in the paw. These effects were prevented by administration of CP-96,345 before stimulation. Additionally, CP-96,345 or an antisense oligonucleotide against NK-1 receptors significantly alleviated mechanical allodynia in neuropathic animals. Finally, mass spectrum of lumbar spinal cord of neu

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Molento, Marcelo Beltrão. "Effect of multidrug resistance modulators on activity against Haemonchus contortus and pharmacokinetics of ivermectin and moxidectin in sheep." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37599.

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Resistance to the avermectin/milbemycin class of anthelmintics in nematodes has become a serious problem worldwide due to their unrestricted usage. Resistance to these compounds is attributed to the over-expression of the transport protein, P-glycoprotein (P-gp). P-gp acts by pumping drug molecules out from the cell or organism, P-gp efflux activity can be blocked using multidrug resistance (MDR) modulators associated with chemotherapy to enhance their therapeutic effect. A series of experiments was undertaken to determine if the association of the anthelmintics, ivermectin (IVM) and moxidecti

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Blackhall, William James. "Genetic variation and multiple mechanisms of anthelmintic resistance in Haemonchus contortus." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37596.

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Anthelmintic treatment of livestock is an important aspect of the control of gastrointestinal parasites. Resistance to anthelmintics is common, and an understanding of resistance requires knowledge of an anthelmintic's mode(s) of action and mechanism(s) of resistance. The parasitic nematode, Haemonchus contortus, has developed resistance to benzimidazoles and avermectins/milbemycins. Proposed mechanisms of resistance are here supported by genetic changes observed in genes whose protein products are believed to interact with these anthelmintics. Statistically significant differences in allele f

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Robichaud-Véronneau, Andrée. "Measurement of the inclusive cross section of p°, f₀(980) and f₂(1270) mesons in deep inelastic scattering at HERA." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98780.

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The production of neutral meson resonances in deep inelastic scattering has been studied in DESY with the ZEUS detector at the HERA collider. The rho 0, f0(980) and f2(1270) total cross sections, as well as differential pT and eta cross sections, were measured in the 0 GeV < pT < 7 GeV and |eta| < 1 ranges. The obtained total cross sections were sr0 = 19.21 +/- 0.92 (stat.) +/- 7.59 (syst.) nb, sf0 = 0.63 +/- 0.04 (stat.) +/- 0.25 (syst.) nb and sf2 = 3.62 +/- 0.02 (stat.) +/- 1.73 (syst.) nb. The cross sections measurements for f0 and f2 mesons are underestimated since acceptances ha

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Belanger, Serge. "Expression of calcitonin gene-related peptide and substance P in cultured dorsal root ganglion neurons following chronic exposure to opiates." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32758.

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The mechanisms involved in morphine tolerance are poorly understood. It was reported that calcitonin gene-related peptide (CGRP) immunoreactivity was increased in the spinal dorsal horn during morphine tolerance and an in vitro repetitive morphine treatment was able to mimic the in vivo results by inducing increases in CGRP- and substance P (SP)-immunoreactive (IR) neurons in cultured dorsal root ganglia (DRG). The aim of this study was to validate the DRG cell culture model by establishing which subtypes of opioid receptors are involved in the induction of CGRP and SP in cultured rat DRG neur

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Hensen, Janina [Verfasser], Margarete [Akademischer Betreuer] Schön, Michael P. [Akademischer Betreuer] Schön, Holger [Akademischer Betreuer] Bastians, and Martin [Akademischer Betreuer] Oppermann. "Die anti-tumorale Wirkung des neuen Phosphoinositid-3-Kinase-Inhibitors BAY 80-6946 auf humane Myelom-Zellen / Janina Hensen. Gutachter: Michael P. Schön ; Holger Bastians ; Martin Oppermann. Betreuer: Margarete Schön." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1066427445/34.

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Al-Ghamdi, Khalid M. "Field and laboratory studies on egg parasitoids of the tarnished plant bug, Lygus lineolaris (P. de B.) (Hemiptera:Miridae) in southwestern Quebec." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37690.

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From 1991 to 1994 inclusively, a field and laboratory study was undertaken on egg parasitoids of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) to determine their potential in controlling their host. Five species were found to parasitize Lygus eggs in southwestern Quebec. They were three mymarids: Anaphes iole Girault, Polynema pratensiphagum (Walley), and Erythmelus miridiphagus Dozier (Mymaridae) and two scelionids: Telenomus nysivorus Huggert and Telenomus n.sp. (a new species near strelzovi Vasiliev) (Scelionidae). The maximum levels of field parasitism by these parasitoid

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Dyck, Timothy Lee. "Experientialist epistemology : Plantinga and Alston on Christian knowledge." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36919.

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This study examines Christian experientialist epistemology as articulated of late by Alvin Plantinga especially and also William Alston. It situates their approach to the epistemic status of Christian belief claims within the overall outlook they have respectively developed on what features generally legitimate beliefs as being rationally responsible or even qualify some true beliefs as constituting knowledge. First to be taken up is Plantinga's journey from considering the deontological justification for basic belief in God to making his own externalist proposal for warranted belief at large.

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