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Dissertations / Theses on the topic 'Receptors fibroblast growth factor'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Petiot, Anita Claire. "Fibroblast growth factor receptors and skeletogenesis." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368708.

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2

Markert, Anja. "Fibroblast growth factor receptors in chemoresistance." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39292.

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Chemoresistance is a major obstacle to successful treatment in many cancers. Identification and dissection of the mechanisms underlying chemoresistance is therefore crucial for finding new therapeutic targets to improve patient survival. One growth factor implicated in chemoresistance is FGF2. It has been shown to be involved in triggering chemoresistance in small cell lung cancer (SCLC) and osteosarcoma cells via the activation of a MAPK-dependent signalling pathway. Similarly, previous work by our group has shown that FGF10 induces chemoresistance in SCLC. Here, we investigated whether FGF2

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3

Grand, Effie Kyriacou. "Deregulated fibroblast growth factor receptors in haematological malignancies." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419978.

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4

Burgar, Helen Rachel. "Fibroblast growth factor receptor signalling." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275129.

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5

Walters, Jean E. "Immunochemical studies on fibroblast growth factor-1 and fibroblast growth factor receptor 1." Thesis, Oxford Brookes University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245703.

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6

Markham, Hilary Jane. "The role of fibroblast growth factor receptors in mammalian odontogenesis." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272151.

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7

Britto, Jonathan Anthony. "Syndromic craniofacial dysostosis : from genotype to phenotype: studies of FGFR gene expression in human craniofacial development and craniosynostosis." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268446.

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8

Drugan, Caroline S. "The role of fibroblast growth factors and their receptors in human oral carcinogenesis." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389231.

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9

Kolanczyk, Maria Elzbieta. "Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1242722157657-12154.

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Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a receptor-dependent manner via tyrosine kinase receptors, four of which have been so far identified. Fgf8 signaling was shown to depend both on receptor activation as well as endocytosis. The specificity of Fgf ligands and receptors as well as the function of receptors in the control of the Fgf signal

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10

Powell, Andrew Keith. "Characterisation of the interaction of fibroblast growth factor receptors with heparan sulphate." Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288866.

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11

Nair, Salil B. "Fibroblast growth factor receptor expression in vestibular Schwannoma." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275584.

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12

Chen, Pei-Yu. "Fibroblast Growth Factor Receptor-1 (FGFR1) in Vascular Smooth Muscle Cell Phenotypic Switch." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/pdf/ChenPY2009.pdf.

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13

Harmer, N. J. "Structural studies of fibroblast growth factors and their receptors." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603723.

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Recent crystal structures have suggested two models for the complex between FGFs, FGF receptors (FGFRs) and the proteoglycan heparin that mediates signalling, and have provided insight into how FGFs show differing affinities for the range of FGFRs. I have examined complexes of FGF, FGFR and heparin by size-exclusion chromatography, analytical ultracentrifugation and mass spectrometry. This analysis suggests that both of the crystal structures faithfully represent the state of the molecules in solution. From this, I conclude that the origin of the difference in the two models lies in the prepar

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14

Nash, Gordon W. "Characterization of fibroblast growth factor receptor type I isoforms in Xenopus laevis embryonic development /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,167327.

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15

Förster, Sabine [Verfasser], and Klaus [Akademischer Betreuer] Brehm. "Nuclear Hormone Receptors and Fibroblast Growth Factor Receptor Signaling in Echinococcus multilocularis / Sabine Förster. Betreuer: Klaus Brehm." Würzburg : Universität Würzburg, 2012. http://d-nb.info/1109770782/34.

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16

Hamade, Fares. "Enhanced bone formation during distraction osteogenesis in FGFR3 deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112630.

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Distraction Osteogenesis (DO) is a technique for bone lengthening and filling of bone defects following trauma, infection or resection of tumors. DO consists of an osteotomy of the bone to be lengthened, followed by controlled distraction of the bone segments with an external fixator until the desired lengthening is obtained (distraction phase). This is followed by the consolidation phase, during which the external fixator is kept in place until the newly formed bone in the distracted zone consolidates. This phase is long and may cause numerous problems. Ongoing research aims at finding a meth

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17

Kreuger, Johan. "Decoding Heparan Sulfate." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5161-6/.

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18

Patey, Susannah Juliet. "Fibroblast growth factor receptor function : analysis through natural mutations." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400436.

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19

Beleza, Meireles Ana Maria. "Hypospadias : analysis of a complex genetic disorder /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-249-1/.

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20

Ryan, Paula. "Characterization of the FGF receptor signaling complex in Xenopus laevis during early embryonic development /." St. John's, NF ; [s.n.], 1999.

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21

Böhm, Friederike. "Cooperative functions of fibroblast growth factor receptors 1 and 2 in liver homeostasis and regeneration /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18385.

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22

Whitney, Marsha L. "Molecular control of skeletal myoblast proliferation for cardiac repair /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8008.

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23

Hartge, Abbie A. "The role of FGF signaling in retinal development." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-053-Hartge-index.htm.

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Thesis (M.S.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on January 29, 2009). Research advisor: Dr. Michael A. Dyer, Ph.D. Document formatted into pages (vi, 47 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 41-44).

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24

Jastrebova, Nadja. "Role of Heparan Sulfate Structure in FGF-Receptor Interactions and Signaling." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8717.

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<p>Heparan sulfate (HS) belongs to the glycosaminoglycan family of polysaccharides and is found attached to protein cores on cell surfaces and in the extracellular matrix. The HS backbone consists of alternating hexuronic acid and glucosamine units and undergoes a number of modification reactions creating HS chains with alternating highly and low modified domains, where high degree of modification correlates with high negative charge. Fibroblast growth factors (FGFs) and their receptors (FRs) both bind to HS, which affect formation of the FGF–FR complexes on the cell surfaces. Activated FRs ca

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25

Magnusson, Peetra. "Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5824.

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26

Patrie, Kevin Michael. "Functional and structural analysis of urodele amphibian and mammalian fibroblast growth factor-1 and its receptors /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476405168.

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27

Oers, Johanna Maria Margareta van. "Activation of the fibroblast growth factor receptor 3 in bladder cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10475.

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28

Drafahl, Kristine A. "The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3355680.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 23, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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29

Rathnakumar, Navin David. "Role of fibroblast growth factor receptor in regulation of membrane traffic." Thesis, Aston University, 2016. http://publications.aston.ac.uk/28888/.

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Several studies show that membrane transport mechanisms are regulated by signalling molecules. Recently, genome-wide screen analyses in C.elegans have enabled scientists to identify novel regulators in membrane trafficking and also signalling molecules which are found to couple with this machinery. Fibroblast growth factor (FGF) via binding to fibroblast growth factor receptor (FGFR) mediate signals which are essential in the development of an organism, patterning, cell migration and tissue homeostasis. Impaired FGFR-mediated signalling has been associated with various developmental, neoplasti

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30

McCabe, Kathryn Leigh. "The transition from progenitor cell to neuron : fibroblast growth factors and their role in retinal ganglion cell neurogenesis /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10640.

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31

Lundin, Lars. "Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3783.

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<p>Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. For proper function, the FGFs and their receptors depend on specific polysaccharide co-receptors, denoted heparan sulfate (HS). This thesis describes HS regulation of FGFR-1 signal transduction using blood vessel endothelial cells as a model.</p><p>We have determined HS structural features, necessary for FGF-2 induced FGFR-1

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32

Manrique, Zuñiga Santiago. "Structural and computational studies of fibroblast growth factor receptor signalling complex formation." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:b6ccd433-f59b-40e6-838e-70aec5553caf.

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Fibroblast growth factor receptor (FGFR) signalling plays a crucial role in embryogenesis, adult tissue development and tissue repair. It has been implicated in a wide range of human pathologies such as cancers and skeletal disorders which is the reason for a particular interest over recent years. Concerted efforts in academia and industry are targeting the FGFR signalling networks at different stages. The intracellular canonical downstream signalling pathways in healthy and pathogenic cells are relatively well understood. A definition of the precise mechanism for ligand induced FGFR dimerisat

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33

Mehta, Piyush Bachoolal. "The roles of fibroblast growth factors and their receptors in human prostate cancer." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311115.

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34

Bresnick, Janine Nicola. "The fibroblast growth factors and their receptors in mammary gland development and malignancy." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307597.

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35

Fanganiello, Roberto Dalto. "Estudo de expressão gênica e de comportamento celular em células de indivíduos portadores de craniossinostoses sindrômicas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-16042010-162021/.

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Um dos grupos de doenças mais importante que acomete o desenvolvimento da caixa craniana humana é o das craniossinostoses, caracterizado pelo fechamento prematuro de uma ou mais suturas cranianas. Entre as formas mendelianas das craniossinostoses sindrômicas, mutações dominantes em FGFR2 são uma das causas mais frequentes e estão associadas às síndromes de Apert, de Crouzon e de Pfeiffer. A sinalização intracelular subseqüente à ativação de FGFR2, tanto selvagem quanto mutante, é bastante intrincada e pode sofrer inúmeras bifurcações. As porções iniciais destas vias, imediatamente subsequ

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36

Kilkenny, Dawn M. "Fibroblast growth factor (FGF) receptor-1 and FGF-2 nuclear localization in proliferating growth plate chondrocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/NQ58142.pdf.

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37

Smith, Simone Marsha-Lee. "The proteoglycan perlecan regulates long bone growth through interactions with developmental proteins in the growth plate." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002155.

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38

Wagner, Andreas. "Identifizierung von Genen, die durch fibroblast growth factor receptor 2 (FGFR2) reguliert werden." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961705361.

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39

Gill, John C. "Developmental regulation of gonadotropin-releasing hormone neurons by fibroblast growth factor receptor signaling." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p3190372.

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40

Knights, Victoria E. E. "Tumour cell responses to novel fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608393.

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41

Cha, Jiyoung Der Channing J. "The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1513.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.

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42

Fletcher, Michael. "Network analysis of fibroblast growth factor receptor 2-regulated gene expression in breast cancer." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608087.

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43

Shah, Riyaz Nazeerul Haq. "The transcriptional mechanisms of fibroblast growth factor receptor type 4 overexpression in pancreatic carcinoma." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271806.

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44

Burger, Patricia E. "The effects of fibroblast growth factor-2 (FGF-2) on haematopoietic cells and the identification of those cells expressing FGF receptors." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/3110.

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45

Poulin, Matthew Leon. "Cloning, characterization and expression analysis of acidic fibroblast growth factor and its receptors during forelimb regeneration in the newt (Notophthalmus viridescens) /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487846885777182.

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46

Valverde, Franco Gladys 1972. "The role of fibroblast growth factor receptor 3 in post-natal cartilage and bone metabolism /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115917.

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FGFR 3 is one of a family of four high affinity receptors for FGF ligands. Activating mutations in FGFR 3 result in skeletal dysplasias that vary in severity from undetectable to neonatal lethal. Mice with congenital deficiency of FGFR3 develop severe kyphosis and skeletal overgrowth. FGFR3 is also expressed in calvarial pre-osteoblasts, osteoblast and articular chondrocytes, although it biological role in these cells remains undefined. By changing the genetic background of the Fgfr3-/- mice we were able to extend their lifespan and examine its impact on post-natal skeletal growth. To investig

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47

Patani, Harshnira Hitesh. "Assessment of fibroblast growth factor receptor cancer-associated mutations and characterisation of endocrine signalling complexes." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045847/.

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Receptor tyrosine kinase (RTK) signalling is frequently deregulated in cancers, developmental syndromes and metabolic diseases. The fibroblast growth factor (FGF) receptor (FGFR) family of RTKs have pleiotropic roles in development, metabolism and tissue homeostasis. A decade of deep sequencing studies has led to the discovery of somatic cancer-associated alterations in FGFRs including point mutations, gene fusions and amplifications. Missense substitutions appear most frequently in FGFR3 and FGFR2, some of which have been implicated as oncogenic drivers. This has led to rapid progress in anti

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48

Griffin, Kevin John Paul. "An analysis of the role of fibroblast growth factor family and its receptors in the embryonic patterning of the zebrafish (Danio reio)." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283203.

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49

Graça, Joao Alberto. "Mechanisms of soft-tissue mineralization induced by the inhibition of the MEK/ERK pathway or the inhibition of fibroblast growth factor receptors." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/85896/.

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Currently in development as anti-cancer drugs, MEK/ERK and FGFR inhibitors have induced soft-tissue mineralization and increased plasma Pi and 1,25-dihydroxyvitamin D3 (1,25D3) levels in pre-clinical studies. AstraZeneca in-house data reported softtissue mineralization in stomach, kidney and heart of rats administered for >7d with MEK (MEKi) or FGFR (FGFRi) inhibitors. In this study, I aimed to unravel the mechanisms of soft-tissue mineralization associated with MEK/ERK or FGFR inhibition by assessing key processes for mineral homeostasis in rats treated with these inhibitors. The main finding

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50

Rajendran, Ranjithkumar [Verfasser]. "Evaluation of the fibroblast growth factor receptor 1 (FGFR1) in experimental autoimmune encephalomyelitis (EAE) / Ranjithkumar Rajendran." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1068922265/34.

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