Dissertations / Theses: 'Structural analogs'

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Park, Ju-Hyun. "Magneto-structural and magneto-optical studies of Prussian blue analogs." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013792.

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Liu, Zhihong. "Structural analysis of amylin and its analogs by NMR spectroscopy /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8657.

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Cheng, Chang-Chung. "Syntheses of chorismate analogs for investigation of structural requirements for chorismate mutase." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/17370.

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Wallace, Raye Ann. "The interaction of structural analogs of dopamine, chlorpromazine and sulpiride with striatal dopamine receptors /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487586889186522.

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Knapp, Steven E. "Synthesis and Structural Analysis of Novel Bis(triazole) UDP Analogs as Potential Glycosyl Transferase Inhibitors." Connect to resource online, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229371574.

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Juntunen, K. (Kari). "Functional and structural characterization of nuclear vitamin D receptor and its ligand binding domain." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514268784.

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Abstract The hormonally active form of vitamin D, 1,25(OH)2D3, is involved in many biological functions throughout the body, such as regulation of calcium and phosphate homeostasis, bone remodeling and controlling cell proliferation and differentiation. Vitamin D receptor (VDR), a member of the nuclear hormone receptor (NHR) super family, mediates those genomic actions of 1,25 (OH)2D3 by actively repressing or activating its target genes. In the present study recombinant human nuclear VDR and its ligand binding domain (LBD) were expressed in Spodoptera frugiperda (Sf9) insect cells and in E.coli. Recombinant proteins were purified and their biochemical and biophysical properties were characterized. Recombinant VDR was shown to bind to the vitamin D response element (VDRE) of osteopontin and osteocalcin genes as a homodimer or as a heterodimer with the retinoid X receptor (RXR)-αΔAB. Full-length VDR and its LBD were demonstrated to bind natural ligand 1,25 (OH)2D3 with high affinity. The binding affinities of several vitamin D analogs were also determined. Ligand binding induced conformational change within the receptor was studied using several methods such as partial proteolytic digestion, small angle neutron scattering (SANS), native gel electrophoresis and circular dichroism (CD) spectroscopy. Results indicate that ligand binding induces conformational change within VDR and different 1,25(OH)2D3 analogs might induce a somewhat different conformation within the receptor. This is seen as an unequal capacity of analogs to stabilize receptor against proteases or heat and as differences in the promotion of receptor homodimerization. Compared to other nuclear hormone receptors, VDR presents a large insertion region at the N-terminal part of the LBD between helices H1 and H3, encoded by an additional exon. In the present study this additional exon was deleted and the properties of mutated LBD were compared to the wild type LBD. Biochemical analyses indicated that the mutant protein exhibits the same ligand binding, dimerization with RXR and transactivation properties as the wild-type VDR, suggesting that the insertion region does not affect these main functions. Furthermore, solution studies by small angle X-ray scattering indicated that the insertion region in the VDR locates on the surface of molecule and it is not structurally well ordered.

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Rowand, Judith K. "Comparative structural studies of proteolyzed human thrombin forms and bovine thrombin through use of hirudin analogs /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688973685458.

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Bonano, Julie S. "Structural Determinants of Abuse-Related Neurochemical and Behavioral Effects of Para-Substituted Methcathinone Analogs in Rats." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3911.

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Methcathinone (MCAT) is the β-ketone analog of methamphetamine, and like its amphetamine analog, MCAT functions as a monoamine releaser that selectively promotes the release of dopamine (DA) and norepinephrine (NE) over serotonin (5-HT). MCAT produces amphetamine-like psychostimulant effects and is classified as a Schedule I drug of abuse by the United States Drug Enforcement Administration (DEA). Recently, synthetic MCAT analogs have emerged as designer drugs of abuse in Europe and the United States and have been marketed under deceptively benign names like “bath salts” in an attempt to evade legal restriction. These dangerous, recently emergent and novel drugs of abuse display varying selectivity to promote release of DA/NE vs. 5-HT, and selectivity for DA neurotransmission is believed to correlate with abuse liability. The goal of this dissertation was to conduct preclinical research to examine structural determinants of abuse-related behavioral and neurochemical effects produced by a series of synthetic MCAT analogs. Specifically, this project focused on one feature of the methcathinone scaffold: the para substituent of the benzene ring. A series of six novel MCAT analogs will be examined to evaluate how physicochemical parameters (steric, Es; electronic, σp; lipophilic, πp) of the para substituent influence in vitro monoamine transporter selectivity as well as in vivo neurochemical and behavioral effects. Results from this body of work implicate steric factors as being particularly important in determining a compound’s abuse-related neurochemical and behavioral effects. Thus, these data not only offer an improved understanding of the mechanism of abuse-related drug effects produced by synthetic MCAT analogs, but also help in the generation of homology models of the human DA and 5-HT transporters (DAT and SERT, respectively).

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Parameswar, Archana R. "Towards development of a fully synthetic conjugate vaccine investigation of structural analogs of Streptococcus pneumoniae serogroup 6 /." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2008. http://etd.umsl.edu/r3161.

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Musca, Vanessa. "Elucidating the Important Structural Features of Aryl Glycosides and Antifreeze Glycoprotein Disaccharide Analogs for Ice Recrystallization Inhibition." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35653.

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Cryopreservation of human red blood cells (RBCs) extends the storage time from 42 days (hypothermic storage limit) to a maximum of 10 years. While this reduces the possibility of RBC shortages in emergency situations, this preservation method is currently limited to individuals with rare blood phenotypes, patients who require autologous blood transfusions, and military applications. Furthermore, cryopreservation is associated with a high degree of cellular damage, which can subsequently reduce the viability of cells post-thaw. The cellular damage incurred upon cryopreservation is primarily attributed to the process of ice recrystallization. To reduce the degree of cellular damage, cryoprotective agents (CPAs) are used. Currently, 10 % dimethyl sulphoxide (DMSO) and 40 % glycerol are used for the cryopreservation of hematopoietic stem cells (HSCs) and human RBCs respectively. Unfortunately, these CPAs do not provide protection against ice recrystallization. The biological antifreezes (BAs) consisting of antifreeze proteins (AFPs) and antifreeze glycoproteins (AFGPs) were identified as the first inhibitors of ice recrystallization. Consequently, the Ben laboratory is interested in synthesizing small molecule carbohydrate-based inhibitors of ice recrystallization that can be used as an alternative to glycerol or DMSO for the cryopreservation of various cell types. Therefore, this thesis focuses on elucidating important structural features of carbohydrate-based derivatives that are responsible for IRI activity. The first part of this study examines the importance of the anomeric oxygen atom of aryl glycosides for IRI activity. Our laboratory previously demonstrated that the O-linked aryl glycosides are effective inhibitors of ice recrystallization. However, the influence of stereoelectronic effects at the C1 position of aryl glycosides on IRI activity has not been investigated. As a result, N- and S-linked aryl glycosides were synthesized in this study and their IRI activities were compared to that of the O-linked aryl glycosides. These results suggest that a stronger exo-anomeric effect exhibited by the C1 nitrogen derivatives reduces the IRI activity of aryl glycosides. The second part of this study focuses on the synthesis of AFGP disaccharide analogs. While the β-(1,3) glycosidic linkage found in native AFGP-8 was previously assessed for its influence on IRI activity, an extensive structure-function analysis of AFGP disaccharide analogs has not yet been performed. As a result, an AFGP disaccharide analog was designed whereby a para-methoxyphenyl (PMP) substituent was incorporated. This was done to assess whether the PMP substituent could enhance the lack of IRI activity exhibited previously with AFGP disaccharide analogs. Although the synthesis of this disaccharide target was not completed, a number of advantageous developments have been made regarding the glycosylation of N-acetyl-D-glycosamine derivatives. In addition, the PMP-GlcNAc intermediate encountered in disaccharide synthesis was assessed for its IRI activity, confirming that the acetamido (NHAc) function is not required for IRI activity.

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Sehgal, Rippa. "Binding of Oxaliplatin and its Analogs with DNA Nucleotides at Variable pH and Concentration Levels." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1602.

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Oxaliplatin is one of the three FDA-approved platinum anticancer drugs and considered a third generation drug, discovered after the first generation drug cisplatin and second generation drug carboplatin. It is known to react with proteins and DNA nucleotides in the body. Reaction with DNA occurs primarily at guanosine residues and secondarily at adenine residues for oxaliplatin and other platinum drugs. We have previously studied oxaliplatin and an analog with additional steric hindrance in the amine ligand and found that the analog had different reactivity with methionine. Now, we have prepared oxaliplatin and its three analogs Pt(Me2dach)(ox), Pt(en)(ox) and Pt(Me4en)(ox) and have reacted each platinum compound with both guanine and adenine nucleotides at pH 4 and pH 7 at different molar ratios. These reactions have been characterized by Nuclear Magnetic Resonance (NMR) spectroscopy equipment over time to observe the formation of products and compare them on the basis of their kinetics and binding affinities. NMR has shown that even under the conditions of excess platinum, the dominant products are usually those with two nucleotides coordinated to one platinum center. Reactions are faster at pH 7 than pH 4 due to deprotonation of phosphate group. Reactions of GMP with a platinum center are faster than reaction with AMP because of the chelate formed by the oxalate ligand. The extra methyl groups on the oxaliplatin analogs do not appear to slow down the reactions with nucleotides considerably. The pH generally affects the rate but does not substantially affect the product distribution.

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Nilsson, Ulf. "Structural requirements for glycolipid receptors recognized by uropathogenic E. coli synthetic and biological studies with fragments and analogs of globo oligosaccharides /." Lund : Organic Chemistry 2, Lund Institute of technology, University of lund, 1995. http://books.google.com/books?id=EjdsAAAAMAAJ.

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Obeid, Samra [Verfasser]. "Snapshots of DNA polymerase processing aberrant substrates : Structural insights into abasic site bypass and polymerization of 5-alkynylated nucleotide analogs / Samra Obeid." Konstanz : Bibliothek der Universität Konstanz, 2011. http://d-nb.info/1024457699/34.

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Bonner, Grady Gregg 1965. "Synthesis, pharmacology, and structural analysis of opioid peptides: Cyclic somatostatin analogs which include unusual amino acids with conformationally restricted side-chain groups." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282318.

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This work relates the activities of Somatostatin-derived opioid peptides to their 3-dimensional structures. Due to the flexability of peptides, they adopt multiple conformations. This flexibility leads to ambiguity in the development of structure-activity profiles. Here flexibility is reduced by incorporation of amino acids with conformationally restricted side-chain groups. These groups are restricted to certain topographies by cyclization or biased through substitution at the beta carbon. The opioid activities of these peptides are determined by brain binding radioligand competition assay, in vitro activity in the mouse vas deferens (MVD) and guinea pig ileum (GPI) smooth muscle twitch-height inhibition assays, and in vivo in the mouse warm water tail-flick latency assay. Their 3-dimensional structures were determined through a variety of 2D 1H NMR including TOCSY, ROESY, DQF-COSY, and COSY-35, as well as molecular modeling including energy minimization and molecular dynamics. By knowing the activity of the peptides, and their preferred conformations, a reasonably confident structure-activity profile was generated.

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Gibson, Meghan E. "Examining the Role of Magnesium Ions in the Structural Stability of Ribosomal Subunits and An Investigation of a Novel Anticancer Therapeutic: Analyzing the Binding Affinity of a Stapled p53 Peptide Analog for Regulator MDM2." Thesis, Boston College, 2011. http://hdl.handle.net/2345/bc-ir:104431.

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Thesis advisor: Udayan Mohanty
Computational research can play a crucial component in the discovery of unique biochemical phenomena, from answering fundamental questions about molecular function and structure to the modeling of designed pharmaceuticals to cure many debilitating illnesses. Here computational methods are employed to examine the exquisite role that magnesium ions play in stabilizing ribosomal subunits responsible for protein translation and to analyze the potential of a proposed anticancer drug for a pathway that is impaired in the majority of human cancer cases
Thesis (BS) — Boston College, 2011
Submitted to: Boston College. College of Arts and Sciences
Discipline: College Honors Program
Discipline: Chemistry

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Marechal, Nils. "Étude structurale des protéine arginine méthyltransférases : reconnaissance des substrats et conception rationnelle de modulateurs." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ048.

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Les protéine arginine méthyltransférases (PRMT) sont impliquées dans de nombreux processus cellulaires, incluant la régulation de l’expression des gènes, le contrôle de l’épissage, le maintien de l’intégrité du génome et la transduction du signal. De nombreuses études montrent que la dérégulation de l’activité des PRMT est associée au développement de pathologies, et en particulier de cancers. Les PRMT constituent ainsi une des nouvelles cibles potentielles en chimiothérapie. Les travaux présentés dans ce manuscrit portent sur trois cibles : PRMT2, PRMT3 et PRMT4/CARM1. Combinant des approches biochimiques, biophysiques et structurales (cristallographie et cryo- microscopie électronique), ces travaux comportent deux aspects : (I) comprendre au niveau atomique la régulation de la réaction de méthylation des protéines (reconnaissance protéines-protéines et interactions entre modifications post-traductionnelles) ; (II) découvrir des inhibiteurs spécifiques et puissants de plusieurs PRMT cibles
Protein arginine methyltransferases (PRMT) are involved in many cellular processes, including gene expression regulation, splicing control, maintenance of genome integrity and signal transduction.Since deregulation of those biological processes appears to be implicated in the pathogenesis of different diseases, PRMTs have emerged as potential new targets for the development of novel therapeutic modulators. Despite the large amount of biological and structural data on PRMTs, two challenges remain to be solved by structural biology ; (I) understanding how PRMTs recognize and bind their full-length substrates ; (II) revealing how PRMTs achieve specific arginine methylation on different target sites. The works presented here focused on 3 targets: PRMT2, PRMT3 and PRMT4/ CARM1. We used biochemical, biophysical and structural methods (bio-crystallography and cryo- electron microscopy) to decipher structural clues that drive PRMT-substrate recognition. We developed new chemical probes that can be used in early drug discovery for the conception of PRMT inhibitors

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Lengyel, András. "Analogy between equilibrium of structures and compatibility of mechanisms." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:457c87b2-5adb-45fc-9799-c2540950996f.

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Planar bar-and-joint mechanisms with one degree-of-freedom are widely used in deployable structures and machines. Such mechanisms are designed to undergo a specific motion, which can be described mathematically by plotting out the compatibility conditions, resulting in a curve called compatibility path. It has been observed that compatibility paths can develop singularities similar to that of equilibrium paths of elastic structures. This dissertation studies singularities occurring in compatibility paths with the aid of knowledge in the theory of structural stability. An analogy is set up between the equilibrium path of elastic structures and the compatibility path of mechanisms with a single degree-of-freedom incorporating the different types of bifurcation, effects of imperfections and detection of singularities. It is shown that the fundamentally distinct critical points such as limit points and bifurcation points can also appear in compatibility path. Methods used to singularities for compatibility conditions of mechanisms and equilibrium of structures are unified so that they can be used for both cases. A formulation of potential energy for mechanisms is also proposed in analogy with the potential energy function used in structural analysis. Further analysis of the mechanisms is carried out to demonstrate that singularities of compatibility paths can also be dealt with by the elementary catastrophe theory similar to the stability theory. A relationship is established between the mathematical formulation of different compatibility bifurcations and the canonical forms of catastrophe types. Examples of mechanisms demonstrating the existence of cuspoids of the compatibility conditions are given. An overall classification of the compatibility paths is also proposed.

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Delacroix-Beaurain, Nathalie. "Conception et synthese de derives benzothiopheniques impliquant les mecanismes melatoninergiques." Lille 2, 2001. http://www.theses.fr/2001LIL2P254.

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Darleux, Robin. "Development of analogous piezoelectric networks for the vibration damping of complex structures." Thesis, Paris, HESAM, 2020. http://www.theses.fr/2020HESAC011.

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Cette thèse de doctorat s'intéresse au développement de réseaux piézoélectriques analogues pour l'amortissement vibratoire de structures complexes. L'objectif est de réduire les vibrations des modes de plus grandes longueur d'ondes de structures, qui sont recouvertes de patchs piézoélectriques dans ce but. Ces patchs permettent de coupler les structures à des réseaux qui présentent des propriétés identiques de propagation d'onde. On obtient de cette façon un amortissement multimodal de la structure. Pour ce faire, on détaille une méthode permettant de définir l'analogue électrique de toute structure mécanique. Cette méthode est ensuite appliquée à des cas standards de propagation d'ondes mécaniques, tels que la traction-compression en 1D, ou la flexion en 1D ou en 2D. On forme ainsi une bibliothèque de cellules électriques analogues. Le cas d'une plaque rectangulaire recouverte de patchs piézoélectriques est traité. Un réseau analogue est assemblé à l'aide d’éléments de librairie précédemment obtenue. Un dimensionnement adéquat des composants magnétiques du réseau assure qu'il soit de nature purement passive. La connexion de la plaque à son réseau analogue résulte en un amortissement multimodal, ce qui prouve l'efficacité de cette solution d'amortissement. En parallèle, un modèle éléments finis d'une structure couplée à un réseau électrique par des patchs piézoélectriques est développé. La comparaison entre résultats expérimentaux et simulés permet de valider ce modèle. Il peut ainsi être utilisé pour finalement aborder l'amortissement large bande de structures complexes. Des exemples numériques de plaques complexes et de structures à une courbure sont traités. Les résultats sont prometteurs, puisqu'ils démontrent la possibilité d'appliquer à des structures complexes l'amortissement multimodal par couplage à des réseaux piézoélectriques analogues purement passifs
This doctoral thesis focuses on the development of analogous piezoelectric networks for broadband damping of complex structures. The objective is to damp the modes of largest wavelengths of mechanical structures, which are covered by piezoelectric patches to this end. This allows coupling them to fully passive electrical devices which exhibit similar wave propagating properties. Multimodal vibration mitigation is hence achieved. To do so, we first propose a method to derive the electrical analogue of any mechanical structure. It is applied to create a library of elementary analogues that represent classical wave propagation cases, such as 1D traction, 1D bending or 2D bending. Then, the electrical analogue of a rectangular plate covered by piezoelectric transducers is assembled with elements from the library. Following design methods of passive inductors and transformers, the produced network is fully passive. Vibration tests prove the mitigation efficiency of the setup when the plate is connected to its analogous network. Meanwhile, we develop a finite element model of a structure covered with thin piezoelectric transducers connected to a lumped element network. Comparisons with experiments validate this model. Thus it is used to finally investigate the achievable performance by of piezoelectric network damping applied to more complex structures. Numerical simulations are performed on complex plates and single curved structures. Results are promising: they highlight it might be possible to develop fully passive piezoelectric analogous networks to damp vibrations of complex structures

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Zoghaib, Wajdi Michel. "Structure/anti-herpes activity studies of pyrimidine nucleoside analogs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24024.pdf.

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Halstead, Daniel T. "Statistical Relational Learning through Structural Analogy and Probabilistic Generalization." NORTHWESTERN UNIVERSITY, 2012. http://pqdtopen.proquest.com/#viewpdf?dispub=3488474.

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Eklöf, Anders M. "Lowcoordinated Silicon and Hypercoordinated Carbon : Structure and Stability of Silicon Analogs of Alkenes and Carbon Analogs of Silicates." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9298.

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Quantum chemical studies on lowcoordinated group 14-16 compounds have been performed. This thesis focuses particularly on silenes influenced by reverse Siδ-=Cδ+ bond polarization. Hypercoordinated carbon compounds are also studied. The geometries from calculations with several common computationally inexpensive methods have been tested against high level CCSD/cc-pVTZ geometries for a series of substituted silenes. Hybrid HF/DFT methods performed best among the inexpensive methods tested for silenes. Heavy alkenes strongly influenced by reverse polarization are found to have less exothermic dimerization energies for both head-to-head and head-to-tail dimerizations, and to have higher activation energies for water addition than naturally polarized heavy alkenes. We also investigated solvated lithium, magnesium and potassium silenolates and found that lithium and magnesium ions coordinate preferably to O, giving their SiC bond some double bond character. Reverse polarized 2-siloxy-, 2-thiosiloxy-, and 2-(N-sila-N-methyl)-silenes could according to calculations be formed thermolytically from the corresponding tetrasilanes as transient species. It was, however, found that silenes highly influenced by π-conjugative reverse polarization have low barriers for the back-reaction, and thus these silenes are more difficult to form as stable species than naturally polarized silenes. It is also found that conjugated 1-siladienes, formed by electrocyclic ring-opening of 1-silacyclobut-2-enes, which are highly influenced by π-conjugative reverse polarization, have higher barriers for electrocyclization back to starting material than naturally polarized 1-siladienes. It is found that CHe54+, CHe64+, CNe54+, and CNe64+ are the closest carbon analogs of SiH5-, SiH62-, SiF5- and SiF62-, respectively. However, due to their exothermic dissociation reaction, these very high-lying local minima will be impossible to reach experimentally.

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Docef, Alen. "Efficient structures for oversampling A/D conversion." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/14975.

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Exner, Ulrike. "Analogue modelling of flanking structures /." [Zurich] : [s.n.], 2005. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16061.

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Barone, Natalie V. "The Synthesis and Characterization of Oxygen Containing Porphyrin Analogs and Rhenium Coordination Chemistry for Diagnostic Imaging." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1217273303.

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Meyers, Ross Owen. "Anticancer Structure-Activity Relationships of Semi-Synthetic Analogs of Nordihydroguaiaretic Acid." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1086%5F1%5Fm.pdf&type=application/pdf.

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Yurek-George, Alexander. "Total synthesis of spiruchostatin A and structural analogues." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442866.

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Olsson, Frida, and Höök Anna Svensson. "Medveten modellering : En kompatibilitetskontroll mellan Tekla Structures 15.0 samt Autodesk Robot Structural Analysis Professional 2010." Thesis, Karlstad University, Karlstad University, Karlstad University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-5852.

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Till grund för detta examensarbete ligger en ineffektiv process, samt dubbelarbete som idag utgör arbetsgången vid CAD-projektering för konstruktörer hos Structor i Karlstad. Målet med examensarbetet är att genomföra en kompatibilitetskontroll av 3D-modelleringsprogrammet Tekla Structures 15.0 mot analys- och beräkningsprogrammen Autodesk Robot Structural Analysis Professional 2010 samt Strusoft FEM-Design. Syftet är att med hjälp av kompatiblitetskontrollen utgöra vilket av programmen Autodesk Robot och FEM-Design som bäst lämpar sig att köras tillsammans med Tekla Structures utifrån valda faktorer. Två äldre examensarbeten används för att få en uppfattning om FEM-Design.

För att undvika det omfattande och tidskrävande arbetet med att skapa två modeller, en grafisk samt en analytisk modell, finns en lösning. Genom att skapa den grafiska modellen i Tekla Structures 15.0, vilket sedermera genererar den analytiska modellen, och sedan exportera den via länk till Autodesk Robot Structural Analysis 2010 behövs bara en modellering. Ett arbetsmoment, som förut inneburit ytterligare en modellering i analysprogrammet, undviks härmed. Medveten modellering, det vill säga kontinuerlig kontroll av den analytiska modellens utseende i Tekla, krävs för mest fördelaktiga resultat. Detta bör finnas i åtanke under hela arbetsprocessen. Det är i slutändan alltid projektören/konstruktören som styr hur Robot i sin tur kommer att behandla modellen som skickas från Tekla.

Laster och lastkombinationer går att justera i både Tekla och Robot. Dock anses det, för en van Teklaanvändare, vara smidigast att hantera detta i Tekla. Om detta sker i Tekla behövs ytterligare inställningar i Robot aldrig göras. Robot utför då endast analysen och bearbetar de resultat som analysen utgör. De resultat som återfinns går att behandla i Robot och redovisas på sätt som är relevanta för respektive användare. De grundläggande resultaten, så som största påverkande moment och tvärkraft, går att importera tillbaka till modellen i Tekla och hamnar då under respektive profils attributinställningar.

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Reisin, Vanessa Raquel. "theatre: analogy of the city reflected inward." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/34834.

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this thesis is an exploration of rational architectural forms and urban ideas. reflections of density, circulation, rhythm, pattern, and punctuation. the formal consequence of two ideas, city and spectacle, manifest in a theatre for the acrobatic performing arts. on the exterior, an autonomous construction where the architecture is a confrontation to the urban world. internally, a world where spectator and spectacle exist playfully through drawing, modeling, and collage. the project brings the structure of the city to the structure of the theatre. theatre as analogy, a city turned inward.
Master of Architecture

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Akis, Tolga. "Lateral Load Analysis Of Shear Wall-frame Structures." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12604713/index.pdf.

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The purpose of this study is to model and analyze the nonplanar shear wall assemblies of shear wall-frame structures. Two three dimensional models, for open and closed section shear wall assemblies, are developed. These models are based on conventional wide column analogy, in which a planar shear wall is replaced by an idealized frame structure consisting of a column and rigid beams located at floor levels. The rigid diaphragm floor assumption, which is widely used in the analysis of multistorey building structures, is also taken into consideration. The connections of the rigid beams are released against torsion in the model proposed for open section shear walls. For modelling closed section shear walls, in addition to this the torsional stiffness of the wide columns are adjusted by using a series of equations. Several shear wall-frame systems having different shapes of nonplanar shear wall assemblies are analyzed by static lateral load, response spectrum and time history methods where the proposed methods are used. The results of these analyses are compared with the results obtained by using common shear wall modelling techniques.

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Liu, Lixuan. "MMV008138 and analogs: potential novel antimalarial agents for P. falciparum." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/95315.

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Malaria is a severe and deadly mosquito-borne disease. Although treatable, the continuous emergence of multi-drug resistant parasite strains urgently calls for the development of novel antimalarial agents. P. falciparum parasites synthesize essential isoprenoid precursors, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), via a non-mevalonate pathway: the methylerythritol phosphate (MEP) pathway. This pathway is not utilized by humans. Thus, compounds that target the MEP pathway and disrupt isoprenoid biosynthesis in P. falciparum hold promise as potent and safe new antimalarial agents, that engage new targets. Previously, we and others identified MMV008138 from the Malaria Box as a MEP pathway targeting compound. Later work revealed that it targets the IspD enzyme within the MEP pathway. Work in the Carlier group has established preliminary structure-activity relationship (SAR) of MMV008138: 1) (1R,3S)-configuration is required; 2) 2', 4'-disubstitution of the D-ring with small, electronegative substituents; 3) functional importance of carboxylate acid at C3. In this work, I aim to gain further insight into the C3 SAR and A-ring SAR of lead compound MMV008138. Synthesized acid bioisosteres and A-ring analogs of MMV008138 were evaluated in their ability to inhibit P. falciparum parasite growth. We showed that the C3 substituent of MMV008138 has a very tight SAR, and likely interacts with a very constricted pocket within the PfIspD enzyme. A-ring modifications are limited to certain positions of MMV001838 and need to be sterically small. However, we have yet to identify a modification that significantly improves drug lead potency. Future work will continue towards understanding the A-ring SAR of MMV008138, as well as D-ring SAR and C1-SAR. Efforts will also be directed towards finding analogs with improved potency, transport and metabolic stability.
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32

Raynal, Lucas. "La sensibilité structurelle des analogies spontanées." Thesis, CY Cergy Paris Université, 2020. http://www.theses.fr/2020CYUN1094.

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L’analogie est un mécanisme fondamental permettant d’interpréter une nouvelle situation à travers des expériences passées. La présente thèse vise à redonner toute sa force à ce postulat en mettant en avant la capacité à percevoir comme essentiellement similaires des expériences d’apparence pourtant différentes. Partant du principe que les analogies constituent un mécanisme naturel par lequel le système cognitif traite l’information nouvelle, un intérêt particulier est attribué à leur manifestation spontanée (i.e. sans incitation par un tiers à effectuer la comparaison), telles qu’elles apparaissent à travers l’assimilation de nouvelles expériences à des conceptions familières stockées en Mémoire à Long Terme (MLT). Ce mécanisme est envisagé comme un moteur du développement conceptuel chez le jeune enfant.Les trois premières études empiriques ont pour objectif de tester l’hypothèse selon laquelle des concepts abstraits familiers sont utilisées pour comprendre la structure profonde des situations rencontrées quotidiennement et évoquer des expériences passées en se basant sur des similitudes structurelles plutôt que superficielles. Les résultats issus de paradigmes expérimentaux de rappel d’histoires écrites, de rappel de situations filmées et d’évocation libre d’expériences personnelles valident notre hypothèse, dévoilant que les situations structurellement similaires sont plus fréquemment évoquées que les situations superficiellement similaires. Compte tenu du rôle des concepts abstraits dans la compréhension, la quatrième étude aborde la question de leur développement chez le jeune enfant. Nous faisons l’hypothèse que les processus cognitifs et neuronaux impliqués lors du traitement d’approximations sémantiques verbales (ex : « elle déshabille l’orange ») par le jeune enfant de 4 ans reflètent le mécanisme par lequel des catégories lexicales aux frontières immatures sont appliquées par analogie à de nouvelles situations. Conformément à notre prédiction, les Potentiels Évoqués (PE) indiquent que les jeunes enfants détectent l’incongruence (effet N400) de verbes inappropriés, mais pas celles des approximations sémantiques.Les implications et les perspectives émergeant de nos résultats sont discutées dans le cadre d’une approche plaçant la capacité à établir spontanément des rapprochements profonds au centre des mécanismes de compréhension de développement des catégories
Analogy is a crucial mechanism allowing one to interpret a new situation in the light of passed experiences. The present dissertation seeks to give this statement back its rightful strength by highlighting the ability to perceive as essentially similar experiences showing a different appearance. Based on the idea that analogies are a natural mechanism through which the cognitive system processes new information, a particular interest will be allotted to their spontaneous expression (i.e. without incitation by someone else to draw the comparison), as their appear through the assimilation of new experiences to familiar concepts stored in long term memory. This mechanism is considered as a motor for young children’s conceptual development.The purpose of the first three empirical studies is to test the hypothesis that familiar concepts are used to understand the deep structure of daily-life situations and to retrieve passed experiences based on structural rather than superficial similarities. Results from experimental paradigms of written story-recall, filmed situation-recall and free-recall of personal experiences confirm our hypothesis, revealing that structurally similar situations are more often retrieved than superficially similar ones. Given the role of abstract concepts in the understanding processes, the fourth study tackles the question of their development during early childhood. Our hypothesis is that cognitive and neural processes involved 4-year-olds’ processing of semantic approximations (e.g. “she is undressing the orange”) reflect the mechanism through which lexical categories with immature boundaries are applied by analogy to new situations. In line with our prediction, event-related potentials’ responses suggest that young children detect incorrect verbs incongruence (N400 effect), but not that of semantic approximations.We discuss implications and perspectives brought about by our results within a framework giving a central place to the ability to draw spontaneous comparisons in understanding processes and categories development

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33

Yamada, Yasuhiro. "3D analogue modelling of inversion structures." Thesis, Royal Holloway, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311874.

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Ben, Hassena Anouar. "Apprentissage par analogie de structures d'arbres." Rennes 1, 2012. http://www.theses.fr/2011REN1E007.

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Les travaux de cette thèse s'inscrivent dans la continuité des travaux faites sur le thème d'apprentissage par analogie dans le projet CORDIAL de l'IRISA. Les efforts précédents ont porté sur l'étude de la proportion analogique dans le cas des objets numériques et symboliques, puis dans le cas de séquences de ces objets, ainsi que sur l'utilisation de ces notions pour l'apprentissage. Nous nous intéressons ici, dans nos travaux, à l'application de ce concept en apprentissage automatique pour le Traitement automatique du langage naturel (TALN), notamment pour l'analyse syntaxique et pour la génération de la prosodie en synthèse de parole. Ceci nécessite de définir le concept de proportion analogique entre quatre structures d'arbres. Notre approche trouve son originalité dans l'utilisation des propriétés hiérarchiques des structures manipulées et dans l'utilisation de mesure de dissemblance analogique (DA) entre ces structures. Son intérêt réside donc dans son adaptation facile à différents contextes et différentes données, quand ceux-ci sont propices à une représentation arborescente. Dans ce cadre, deux algorithmes ont été mis en place pour calculer la DA entre quatre structures d'arbres et pour résoudre une équation analogique. Le principe de notre démarche réside à étendre la notion connue d'alignement entre deux arbres à quatre (ou un plus grand nombre) d'arbres et de profiter des propriétés de l'alignement lors de la définition de l'analogie sur les structures d'arbres en question. Les applications de notre démarche se sont attachées à des problèmes de traitement de langue, notamment en analyse syntaxique et la génération de paramètres prosodiques. Le principe est le même dans les deux cas. Pour ce faire, il est nécessaire de détecter une dissemblance analogique dans le domaine source et de faire l'hypothèse qu'elle pourrait s'appliquer dans le domaine cible. Les résultats se sont montrés encourageants dans leur globalité, en tout cas comparés à la méthode du plus proche voisin. De profondes améliorations sont encore nécessaires, principalement dans la complexité des algorithmes. Nous souhaitons que leur réalisation ultérieure permette d'appliquer cette méthode, qui nous semble prometteuse, à des problèmes variés.

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35

Bladh, Håkan. "Structure-activity studies of novel colchicine analogs synthesis, conformation and tublin binding /." Lund : Lund University, 1998. http://books.google.com/books?id=1sBqAAAAMAAJ.

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36

Stewart, Charlotte. "Structure activity relationships of bisphosphonate analogues." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=128207.

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The nitrogen-containing bisphosphonates (NBPs) are the most widely used treatment for diseases involving excessive osteoclastic bone resorption, such as osteoporosis. The clinical efficacy of NBPs is due in large part to their affinity for bone mineral, but it has been suggested that lowering affinity may have benefits due to altered distribution and duration of action possibly allowing direct anti-tumour effects. In addition, the phosphonocarboxylate (PC) analogues inhibit prenylation more selectively through a different enzyme target, Rab geranylgeranyl transferase (RGGT), which may offer additional benefits by reducing side-effects associated with farnesyl diphosphate synthase (FPPS) inhibition. Using fluorescent analogues of PCs and NBPs demonstrated that mineral affinity not only affects initial bone-binding, but also influences desorption, reattachment and penetration at the bone surface, suggesting that lower affinity compounds have lower retention and increased access to other cell types, such as tumour cells. The work presented aimed to investigate the potential of low affinity analogues by characterising their intracellular potency for inhibiting their target enzymes. The results showed that modification to the phosphonate groups to produce phosphonoalkylphosphinate analogues reduced potency for inhibiting FPPS. By contrast, removal of one of the phosphonate groups to give a monophosphonate changed the target enzyme to RGGT. Modifications to the R1 side-chain (substituting with hydrogen or a halogen) of both NBPs and PCs were studied and showed contrasting results, modifications to the R1 side-chain of NBPs affect their ability to inhibit FPPS whereas the same modification to PCs is insignificant for inhibiting RGGT. This showed the distinction between the structural requirements for inhibition of RGGT and FPPS and furthers the understanding of the structure-activity relationships of both NBPs and PCs which could guide future drug design. Within this thesis the most potent inhibitor of RGGT to date, 3-IPEHPC, was characterised which in addition to having therapeutic potential may be used as tool to investigate the importance of Rab prenylation for cellular function.

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37

Spinks, Stephen James. "Fault simulation for structural testing of analogue integrated circuits." Thesis, University of Hull, 1998. http://hydra.hull.ac.uk/resources/hull:8047.

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In this thesis the ANTICS analogue fault simulation software is described which provides a statistical approach to fault simulation for accurate analogue IC test evaluation. The traditional figure of fault coverage is replaced by the average probability of fault detection. This is later refined by considering the probability of fault occurrence to generate a more realistic, weighted test metric. Two techniques to reduce the fault simulation time are described, both of which show large reductions in simulation time with little loss of accuracy. The final section of the thesis presents an accurate comparison of three test techniques and an evaluation of dynamic supply current monitoring. An increase in fault detection for dynamic supply current monitoring is obtained by removing the DC component of the supply current prior to measurement.

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38

Roussel, Patrick Gabriel. "Synthesis of structural analogues of ecdysone and 20-hydroxyecdysone." Thesis, University of Exeter, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239384.

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39

Brown, Rebecca E. "Studies towards the synthesis of lophotoxin and structural analogues." Thesis, University of Cambridge, 1998. https://www.repository.cam.ac.uk/handle/1810/272050.

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40

Fannin, Christopher A. "Design of an Analog Adaptive Piezoelectric Sensoriactuator." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/37020.

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In order for a piezoelectric transducer to be used as a sensor and actuator simultaneously, a direct charge due to the applied voltage must be removed from the total response in order to allow observation of the mechanical response alone. Earlier researchers proposed electronic compensators to remove this term by creating a reference signal which destructively interferes with the direct piezoelectric charge output, leaving only the charge related to the mechanical response signal. This research presents alternative analog LMS adaptive filtering methods which accomplish the same result. The main advantage of the proposed analog compensation scheme is its ability to more closely match the order of the adaptive filter to the assumed dynamics of the piezostructure using an adaptive first-order high-pass filter. Theoretical and experimental results are provided along with a discussion of the difficulties encountered in trying to achieve perfect compensation of the feedthrough capacitive charge on a piezoelectric wafer.
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41

Yildirim, Egemen. "Development Of Multi-layered Circuit Analog Radar Absorbing Structures." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614314/index.pdf.

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A fast and efficient method for the design of multi-layered circuit analog absorbing structures is developed. The method is based on optimization of specular reflection coefficient of a multi-layered absorbing structure comprising of lossy FSS layers by using Genetic Algorithm and circuit equivalent models of FSS layers. With the introduced method, two illustrative absorbing structures are designed with -15 dB reflectivity for normal incidence case in the frequency bands of 10-31 GHz and 5-46 GHz, respectively. To the author&rsquo
s knowledge, designed absorbers are superior in terms of frequency bandwidth to similar studies conducted so far in the literature. For broadband scattering characterization of periodic structures, numerical codes are developed. The introduced method is improved with the employment of developed FDTD codes to the proposed method. By taking the limitations regarding production facilities into consideration, a five-layered circuit analog absorber is designed and manufactured. It is shown that the manufactured structure is capable of 15 dB reflectivity minimization in a frequency band of 3.2-12 GHz for normal incidence case with an overall thickness of 14.2 mm.

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42

Glidden, Michael D. II. "Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522270994798884.

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43

Galcéra, Marie-Odile. "Thio-oligosaccharides analogues structuraux de messages cellulaires." Grenoble 1, 1990. http://www.theses.fr/1990GRE10136.

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Le motif structural gluco-oligosaccharidique ramifie beta-(1->3) (1->6) est rencontre dans des polysaccharides fongiques immunostimulants aussi bien que comme composants d'heptasaccharides eliciteurs d'alexines chez le vegetal. Dans le premier cas, le motif repetitif comporte une structure tetrasaccharidique a chaine principale beta-(1->3) ramifiee beta-(1->6) alors que dans le second cas, la chaine principale est beta-(1->6) avec des ramifications beta-(1->3 alternees. Dans le but de disposer de modeles oligosaccharidiques susceptibles de contribuer a la connaissance des mecanismes de defense du vegetal et de cet aspect de l'immunostimulation non specifique chez l'animal, des analogues structuraux de ces oligosaccharides comportant des liaisons interosidiques soufrees beta-(1->3) (1->6) ont ete prepares. Ce memoire rapporte notamment la synthese d'analogues des gentiobiose, gentiotriose, laminaribiose, 3#1-beta-d-glucopyranosyl-gentiobiose, 3#2-beta-d-glucopyranosyl-gentiotriose, 6#2beta-d-glucopyranosyl-laminaritriose et 3#1,3#3-di-beta-d-glucopyranosyl-laminaritetraose. Des techniques de synthese thio-oligosaccharidiques basees sur l'activation nucleophile de 1-thioglycoses ont ete developpees

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44

Ciret, Charles. "Photo-induced waveguide structures and quantum analogies." Doctoral thesis, LMOPS, Université de Lorraine, Metz, France, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/218459.

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45

Chen, Ru. "Isolation, structure elucidation and approaches to the partial synthesis of new taxol analogs." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-11102009-020316/.

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46

BRAND, GUY. "Cycloputrescines, cyclospermidines et cyclospermines analogues structuraux de polyamines naturelles. Conception, syntheses et etudes physico-chimiques, infographiques et structurales." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13183.

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Une partie de cette these est consacree a la conception de nouveaux analogues structuraux cycliques de la putrescine, de la spermidine et de la spermine, a leurs etudes physico-chimiques par rmn et par ph-metrie, a l'etude theorique par modelisation moleculaire et aux evaluations de ces molecules sur differents modeles biologiques (cancerologie, immunopathologie et pharmacologie cardio-vasculaire). D'autre part, les temps de relaxation #1#3c pour differents etats de protonation de ces composes ont ete mesures. Ce type d'etude permet d'avoir une information sur le degre de rigidification des composes. Les simulations ont permis de mettre en evidence la stabilisation des cyclopolyamines par une liaison hydrogene intramoleculaire. La mise au point de la synthese des cyclopolyamines a conduit a des intermediaires reactionnels de type bisamidines, capables de former des solides cristallins dans lesquels les entites complementaires sont assemblees par liaisons hydrogene: fils ou rubans moleculaires, feuillets moleculaires, la dimensionnalite de ces solides a ete modulee par modifications des briques moleculaires utilisees

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47

Fluet-Chouinard, Adrien. "Synthesis of Analogs of a Potential Drug for Treatment of Epilepsy." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39257.

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Prior work in the Durst group had generated more than forty analogs of the potent anticonvulsant isoxylitone isolated isolated from a medicinal plant Delphinium denudatum Wall. The nitrile designated as TD532 was the most potent compound generated by A. Saikaley. The starting material for the synthesis of TD532 is isophorone. The observation that TD532 showed considerable potential as an anticonvulsant suggested that other cyclohexenones might have have similar activity. During this project close to fifty derivatives of cyclohex-2-enone, focusing mainly on 3-arylcylohex-2-enones, were prepared. The synthesis of these compounds is described and structure activity relationships are discussed. Based on all the available structure activity data, we have designated the indicated portion of structure A as the pharmacophore for anticonvulsant and anti-epileptic activity. The ester designated as TD561 (compound 40) showed excellent potential in both in vitro and in vivo assays. It has been shown to be a pro-drug of the corresponding acid TD562 (compound 48). These two compounds and the sodium salt of TD562 are currently undergoing final pre-clinical studies at the Center for Drug Research and Development in Vancouver. Five analogs, including TD561 are also under investigation by the Epilepsy and Seizure Division of the US National Institutes of Health.

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48

Smith, Adam Luke. "Characterization of excitatory amino acid receptors using novel structural analogues." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302953.

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49

Jackson, Stuart Andrew. "Representation grounding : investigating a connectionist procedural semantics for structural analogues." Thesis, University of Exeter, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332929.

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50

Gormley, Niall Anthony. "A structural investigation of ras oncoproteins using guanine nucleoside analogues." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317684.

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Dissertations / Theses on the topic 'Structural analogs'

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