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Journal articles on the topic 'Urinary clusterine'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Sambara, Yuliana, Mansyur Arif, and Uleng Bahrun. "Pathomechanism of Renal Damage in Type 2 Diabetes Mellitus Patients." Indonesian Biomedical Journal 5, no. 3 (2013): 161. http://dx.doi.org/10.18585/inabj.v5i3.66.

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BACKGROUND: Hyperglycemia in diabetic patients cause both chronic inflammation and extracellular matrix accumulation that can lead to progressive renal damage. Albumin, Gammaglutamytransferase (GGT) and clusterin in urine are markers to detect damage in glomerulus, cell of the tubules and proximal tubules, respectively.METHODS: This study aimed to evaluate the pathomechanism of haemoglobin A1c (HbA1c), albumin, GGT, clusterin, type IV collagen in urine, and high sensitivity C-reactive protein (hsCRP) in type 2 diabetes mellitus (DM) patients. The study was a cross sectional study involving 82

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Musiał, Kinga, Monika Augustynowicz, Izabella Miśkiewicz-Migoń, Krzysztof Kałwak, Marek Ussowicz, and Danuta Zwolińska. "Clusterin as a New Marker of Kidney Injury in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Pilot Study." Journal of Clinical Medicine 9, no. 8 (2020): 2599. http://dx.doi.org/10.3390/jcm9082599.

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Background and aims: The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney injury molecule (KIM)-1) and functional (cystatin C) markers. Material and methods: Serum and urinary clusterin, KIM-1 and cystatin C concentrations were assessed by ELISA in 27 children before alloHSCT, 24 h, 1, 2, 3 and 4 weeks after alloHSCT and in controls. Results: All paramet

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Dodiya, Hardik, Mukul Jain, and Sunita S. Goswami. "Renal Toxicity of Lisinopril and Rosuvastatin, Alone and in Combination, in Wistar Rats." International Journal of Toxicology 30, no. 5 (2011): 518–27. http://dx.doi.org/10.1177/1091581811415293.

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The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. Rosuvastatin at 2 different doses showed increase in urinary microalbumin levels whereas lisinopril and its combination with rosuvastatin at 2 different doses did not show urinary microalbumin excretion indicating beneficial effects of lisinopril in terms of reducing microalbumin. Urinary clusterin levels significantly increased in high-dose

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Martynova, Ekaterina V., Adelya N. Maksudova, Venera G. Shakirova, et al. "Urinary Clusterin Is Upregulated in Nephropathia Epidemica." Disease Markers 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/8658507.

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Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to

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Esteban-Fernández, Adelaida, Clara Ibañez, Carolina Simó, Begoña Bartolomé, and Victoria Moreno Arribas. "Metabolome-based clustering after moderate wine consumption." OENO One 54, no. 3 (2020): 455–67. http://dx.doi.org/10.20870/oeno-one.2020.54..2983.

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Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an

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Jiang, Yuan-Hong, Jia-Fong Jhang, Jen-Hung Wang, Ya-Hui Wu, and Hann-Chorng Kuo. "Applying K-Means Cluster Analysis to Urinary Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome: A New Perspective on Disease Classification." International Journal of Molecular Sciences 26, no. 8 (2025): 3712. https://doi.org/10.3390/ijms26083712.

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This study applied K-means cluster analysis to urinary biomarker profiles in interstitial cystitis/bladder pain syndrome (IC/BPS) patients, aiming to provide a new perspective on disease classification and its clinical relevance. We retrospectively analyzed urine samples from 127 IC/BPS patients and 30 controls. The urinary levels of 10 inflammatory cytokines and three oxidative stress markers (8-hydroxy-2-deoxyguanosin [8-OHdG], 8-isoprostane, and total antioxidant capacity [TAC]) were quantified. K-means clustering was performed to identify biomarker-based patient subgroups. IC/BPS patients

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7

Eti, S., C. Y. Cheng, A. Marshall, and M. M. Reidenberg. "Urinary Clusterin in Chronic Nephrotoxicity in the Rat." Experimental Biology and Medicine 202, no. 4 (1993): 487–90. http://dx.doi.org/10.3181/00379727-202-43564.

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García-Martínez, Juan D., Asta Tvarijonaviciute, José J. Cerón, Marco Caldin, and Silvia Martínez-Subiela. "Urinary clusterin as a renal marker in dogs." Journal of Veterinary Diagnostic Investigation 24, no. 2 (2012): 301–6. http://dx.doi.org/10.1177/1040638711435112.

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9

Mavrogeorgis, Emmanouil, Sophie Valkenburg, Justyna Siwy, et al. "Integration of Urinary Peptidome and Fecal Microbiome to Explore Patient Clustering in Chronic Kidney Disease." Proteomes 12, no. 2 (2024): 11. http://dx.doi.org/10.3390/proteomes12020011.

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Millions of people worldwide currently suffer from chronic kidney disease (CKD), requiring kidney replacement therapy at the end stage. Endeavors to better understand CKD pathophysiology from an omics perspective have revealed major molecular players in several sample sources. Focusing on non-invasive sources, gut microbial communities appear to be disturbed in CKD, while numerous human urinary peptides are also dysregulated. Nevertheless, studies often focus on isolated omics techniques, thus potentially missing the complementary pathophysiological information that multidisciplinary approache

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10

Purohit, Rajveer S., and Marshall L. Stoller. "Stone clustering of patients with cystine urinary stone formation." Urology 63, no. 4 (2004): 630–34. http://dx.doi.org/10.1016/j.urology.2003.11.045.

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11

Aulitzky, W. K., P. N. Schlegel, D. Wu, et al. "Measurement of Urinary Clusterin as an Index of Nephrotoxicity." Experimental Biology and Medicine 199, no. 1 (1992): 93–96. http://dx.doi.org/10.3181/00379727-199-43335.

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12

McDuffie, J. E., Y. Chen, J. Y. Ma, et al. "Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine." Toxicology Research 5, no. 4 (2016): 1202–15. http://dx.doi.org/10.1039/c5tx00497g.

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In dogs, CDDP induced corticomedullary tubular lesions [A.]; clusterin (CLU) staining in damaged medullary tubules [B.]; and elevated urinary CLU [C.]. Baseline CLU was detected from Control dogs [A. and C.].

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13

Solichova, Pavlina, Michal Karpisek, Radka Ochmanova, et al. "Urinary clusterin concentrations - a possible marker of nephropathy? Pilot study." Biomedical Papers 151, no. 2 (2007): 233–36. http://dx.doi.org/10.5507/bp.2007.039.

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Tian, Jing-Hui, Chung-You Tsai, Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, and Hann-Chorng Kuo. "Clustering of Urinary Biomarkers to Identify Interstitial Cystitis Subtypes and Different Clinical Characteristics and Treatment Outcomes." Biomedicines 13, no. 2 (2025): 369. https://doi.org/10.3390/biomedicines13020369.

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Purpose: Interstitial cystitis/bladder pain syndrome (IC/BPS) is mysterious and difficult to diagnose without cystoscopic hydrodistention. This study aimed to explore non-invasive and highly reliable urine biomarkers to identify Hunner’s IC (HIC) and different non-Hunner’s IC (NHIC) subtypes. Methods: In total, 422 women with and without clinically diagnosed IC/BPS (n = 376 and 46, respectively) were retrospectively enrolled. Patients were diagnosed with HIC or NHIC by cystoscopic hydrodistention under anesthesia. Then, the maximal bladder capacity (MBC) and glomerulation grade were determined

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Wu, Chao-Yi, Huang-Yu Yang, Hui-Ping Chien, Min-Hua Tseng, and Jing-Long Huang. "Urinary clusterin—a novel urinary biomarker associated with pediatric lupus renal histopathologic features and renal survival." Pediatric Nephrology 33, no. 7 (2018): 1189–98. http://dx.doi.org/10.1007/s00467-018-3924-4.

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Demidova, K. N., D. A. Morozov, V. V. Rostovskaya, O. L. Morozova, O. V. Staroverov, and O. S. Shmyrov. "Mathematical analysis of individual biomarker profiles of kidney damage in children with vesicoureteral reflux." Voprosy praktičeskoj pediatrii 17, no. 1 (2022): 43–52. http://dx.doi.org/10.20953/1817-7646-2022-1-43-52.

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Objective. To assess the severity of lesions to renal parenchyma in children with grade II–IV vesicoureteral reflux (VUR) using hierarchical clustering based on the analysis of individual profiles of urinary biomarkers. Patients and methods. In this study, we evaluated the excretion of urinary biomarkers of inflammation (IL-8, IL-18, MCP-1), angiogenesis (VEGF), and fibrogenesis (TGF-β1) and compared them with clinical and demographic parameters of 65 patients with grade II–IV VUR aged 1 to 17 years (mean age 4.9 ± 3.1 years) with a normal glomerular filtration rate (GFR). The control group co

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Liu, Jianing, and Kai Wang. "Disentangling the Relationship Between Urinary Metal Exposure and Osteoporosis Risk Across a Broad Population: A Comprehensive Supervised and Unsupervised Analysis." Toxics 12, no. 12 (2024): 866. http://dx.doi.org/10.3390/toxics12120866.

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Background: Limited evidence links urinary metal exposure to osteoporosis in broad populations, prompting this study to cover this knowledge gap using supervised and unsupervised approaches. Methods: This study included 15,923 participants from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. Urinary concentrations of nine metals—barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), and tungsten (Tu)—were measured using inductively coupled plasma mass spectrometry (ICP-MS). Osteoporosis was assess

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Khasanova, Aiperi K., Vera S. Dobrodeeva, Natalia A. Shnayder, et al. "Blood and Urinary Biomarkers of Antipsychotic-Induced Metabolic Syndrome." Metabolites 12, no. 8 (2022): 726. http://dx.doi.org/10.3390/metabo12080726.

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Metabolic syndrome (MetS) is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Antipsychotic (AP)-induced MetS (AIMetS) is the most common adverse drug reaction (ADR) of psychiatric pharmacotherapy. Herein, we review the results of studies of blood (serum and plasma) and urinary biomarkers as predictors of AIMetS in patients with schizophrenia (Sch). We reviewed 1440 studies examining 38 blood and 19 urinary metabolic biomarkers, including uri

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Wang, Xin, Carrie A. Karvonen-Gutierrez, William H. Herman, Bhramar Mukherjee, Siobán D. Harlow, and Sung Kyun Park. "Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e001233. http://dx.doi.org/10.1136/bmjdrc-2020-001233.

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IntroductionEnvironmental exposure to metals may play a role in the pathogenesis of diabetes; however, evidence from human studies is limited. We prospectively evaluated the associations of 20 urinary metal concentrations and their mixtures with incident diabetes in the Study of Women’s Health Across the Nation, a multisite, multiethnic cohort study of midlife women.Research design and methodsThe sample included 1237 white, black, Chinese and Japanese-American women, aged 45–56 years, free of diabetes at baseline (1999–2000) who were followed through 2016. Concentrations of 20 metals (arsenic,

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Sandelius, Åsa, Jayati Basak, Mikko Hölttä, et al. "Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity." Toxicologic Pathology 48, no. 8 (2020): 981–93. http://dx.doi.org/10.1177/0192623320964391.

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Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glucosaminidase, neutrophil gelatinase-associated lipocalin (NGAL), and osteopontin, for monitoring kidney toxicity in early clinical trials. The qualification was based on small molecule drugs in humans, and the full panel has not been assessed in other species or for other drug mod

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Pais, Gwendolyn M., Jiajun Liu, Sean N. Avedissian, et al. "1335. A Translational Nephrotoxicity Model to Probe Acute Kidney Injury with Vancomycin and Piperacillin–Tazobactam." Open Forum Infectious Diseases 6, Supplement_2 (2019): S483. http://dx.doi.org/10.1093/ofid/ofz360.1199.

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Abstract Background Vancomycin and piperacillin–tazobactam (VAN+TZP) are two of the most commonly utilized antibiotics in the hospital setting and are reported in clinical studies to increase acute kidney injury (AKI). However, no clinical study has demonstrated that synergistic AKI occurs, only that serum creatinine increases with VAN+TZP. Previous preclinical work demonstrated that novel urinary biomarkers and histopathologic scores were not increased in the VAN+TZP group compared with VAN alone. The purpose of this study was to assess changes in urinary output and plasma creatinine between

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Tractenberg, Rochelle E., Suzanne L. Groah, Jamie K. Frost, Futoshi Yumoto, Amanda K. Rounds, and Inger H. Ljungberg. "Urinary Symptoms Among People With Neurogenic Lower Urinary Tract Dysfunction (NLUTD) Vary by Bladder Management." Topics in Spinal Cord Injury Rehabilitation 29, no. 3 (2023): 31–43. http://dx.doi.org/10.46292/sci22-00065.

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Objectives To determine whether assessment and decision-making around urinary symptoms in people with neurogenic lower urinary tract dysfunction (NLUTD) should depend on bladder management. Methods Three surveys of urinary symptoms associated with NLUTD (USQNBs) were designed specific to bladder management method for those who manage their bladders with indwelling catheter (IDC), intermittent catheter (IC), or voiding (V). Each was deployed one time to a national sample. Subject matter experts qualitatively assessed the wording of validated items to identify potential duplicates. Clustering by

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Laping, N. J., B. A. Olson, J. R. Day, et al. "The age-related increase in renal clusterin mRNA is accelerated in obese Zucker rats." Journal of the American Society of Nephrology 9, no. 1 (1998): 38–45. http://dx.doi.org/10.1681/asn.v9138.

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Clusterin is a multifunctional glycoprotein associated with development and tissue injury. Because renal function decreases with advancing age in the obese Zucker rat, clusterin mRNA expression was examined in the kidney of young adult Zucker rats and compared with age-related changes in renal clusterin mRNA expression in Fischer 344 (F344) rats. Renal clusterin mRNA levels in the obese Zucker rat were 2.5-fold higher by 3 mo of age and fourfold higher at 5 mo of age compared with the lean strain. In comparison, renal clusterin mRNA in 12-mo-old F344 rats was twofold higher than in 3-mo-old an

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Heo, Jung-Yoon, Ji-Eun Kim, Yongwook Dan, et al. "Clusterin deficiency induces lipid accumulation and tissue damage in kidney." Journal of Endocrinology 237, no. 2 (2018): 175–91. http://dx.doi.org/10.1530/joe-17-0453.

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Clusterin is a secretory glycoprotein that is involved in multiple physiopathological processes, including lipid metabolism. Previous studies have shown that clusterin prevents hepatic lipid accumulation via suppression of sterol regulatory element-binding protein (SREBP) 1. In this study, we examined the role of clusterin in renal lipid accumulation in clusterin-knockout mice and NRK52e tubular epithelial cells. Clusterin deficiency increased the expression of SREBP1 and its target genes and decreased malonyl-CoA decarboxylase protein levels in the kidney. Expression of the endocytic receptor

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Pan, Heng-Chih, Chiao-Yin Sun, Thomas Tao-Min Huang, et al. "Distinct Subtyping of Successful Weaning from Acute Kidney Injury Requiring Renal Replacement Therapy by Consensus Clustering in Critically Ill Patients." Biomedicines 10, no. 7 (2022): 1628. http://dx.doi.org/10.3390/biomedicines10071628.

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Background: Clinical decisions regarding the appropriate timing of weaning off renal replacement therapy (RRT) in critically ill patients are complex and multifactorial. The aim of the current study was to identify which critical patients with acute kidney injury (AKI) may be more likely to be successfully weaned off RRT using consensus cluster analysis. Methods: In this study, critically ill patients who received RRT at three multicenter referral hospitals at several timepoints from August 2016 to July 2018 were enrolled. An unsupervised consensus clustering algorithm was used to identify dis

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Vlasakova, Katerina, Sean P. Troth, Frank D. Sistare, and Warren E. Glaab. "Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates." Toxicologic Pathology 48, no. 5 (2020): 633–48. http://dx.doi.org/10.1177/0192623320932159.

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To date, there has been very little published data evaluating the performance of novel urinary kidney biomarkers in nonhuman primates (NHPs). To assess the biomarker performance and characterize the corresponding histomorphologic patterns of tubular renal injury in the NHP, several studies were conducted using mechanistically diverse nephrotoxicants including cefpirome, cisplatin, naproxen, cyclosporine, and a combination of gentamicin with everninomicin. An evaluation of 10 urinary biomarkers (albumin, clusterin, cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin

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Chieng, Catherine C. Y., Qingyang Kong, Natasha S. Y. Liou, et al. "Novel Techniques to Unravel Causative Bacterial Ecological Shifts in Chronic Urinary Tract Infection." Pathogens 14, no. 3 (2025): 299. https://doi.org/10.3390/pathogens14030299.

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Chronic urinary tract infection (UTI) presents with protracted lower urinary tract symptoms and elevated urinary leukocyte counts, but its bacterial etiological agents remain obscure. In this cross-sectional investigation, we aimed to unravel the role of the bladder microbiota in chronic UTI pathogenesis by studying the host immune response. Urine samples were collected from healthy controls (HT), chronic UTI patients who had not initiated treatment (PT) and those undergoing treatment (OT), then sorted into white blood cell (WBC) and epithelial cell (EPC) fractions. Bacteria associated with bo

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Rosen Vollmar, Ana K., Nicholas J. W. Rattray, Yuping Cai, et al. "Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches." Metabolites 9, no. 10 (2019): 198. http://dx.doi.org/10.3390/metabo9100198.

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Metabolomics studies of the early-life exposome often use maternal urine specimens to investigate critical developmental windows, including the periconceptional period and early pregnancy. During these windows changes in kidney function can impact urine concentration. This makes accounting for differential urinary dilution across samples challenging. Because there is no consensus on the ideal normalization approach for urinary metabolomics data, this study’s objective was to determine the optimal post-analytical normalization approach for untargeted metabolomics analysis from a periconceptiona

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Adams, William M., Michael Wininger, Mitchell E. Zaplatosch, Derek J. Hevel, Jaclyn P. Maher, and Jared T. McGuirt. "Influence of Nutrient Intake on 24 Hour Urinary Hydration Biomarkers Using a Clustering-Based Approach." Nutrients 12, no. 10 (2020): 2933. http://dx.doi.org/10.3390/nu12102933.

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Previous work focusing on understanding nutrient intake and its association with total body water homeostasis neglects to consider the collinearity of types of nutrients consumed and subsequent associations with hydration biomarkers. Therefore, the purpose of this study was to analyze consumption patterns of 23 a priori selected nutrients involved in osmotic homeostasis, as well as their association with 24 h urinary hydration markers among fifty African–American first-year college students through a repeated measures observation in a daily living setting. Through application of hierarchical c

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Mena, Pedro, Claudia Favari, Animesh Acharjee, et al. "Metabotypes of flavan-3-ol colonic metabolites after cranberry intake: elucidation and statistical approaches." European Journal of Nutrition 61, no. 3 (2021): 1299–317. http://dx.doi.org/10.1007/s00394-021-02692-z.

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Abstract Purpose Extensive inter-individual variability exists in the production of flavan-3-ol metabolites. Preliminary metabolic phenotypes (metabotypes) have been defined, but there is no consensus on the existence of metabotypes associated with the catabolism of catechins and proanthocyanidins. This study aims at elucidating the presence of different metabotypes in the urinary excretion of main flavan-3-ol colonic metabolites after consumption of cranberry products and at assessing the impact of the statistical technique used for metabotyping. Methods Data on urinary concentrations of phen

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Gordin, Emilia, Sanna Viitanen, Daniel Gordin, et al. "A Clinical Study on Urinary Clusterin and Cystatin B in Dogs with Spontaneous Acute Kidney Injury." Veterinary Sciences 11, no. 5 (2024): 200. http://dx.doi.org/10.3390/vetsci11050200.

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Novel biomarkers are needed in diagnosing reliably acute kidney injury (AKI) in dogs and in predicting morbidity and mortality after AKI. Our hypothesis was that two novel tubular biomarkers, urinary clusterin (uClust) and cystatin B (uCysB), are elevated in dogs with AKI of different etiologies. In a prospective, longitudinal observational study, we collected serum and urine samples from 18 dogs with AKI of different severity and of various etiology and from 10 healthy control dogs. Urinary clusterin and uCysB were compared at inclusion between dogs with AKI and healthy controls and remeasure

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Mayhew, Terry M. "CROSS-CORRELATION ANALYSIS OF THE SPATIAL INTERACTIONS BETWEEN TISSUE COMPARTMENTS OF THE RENAL CORPUSCLE." Image Analysis & Stereology 21, no. 3 (2011): 151. http://dx.doi.org/10.5566/ias.v21.p151-155.

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The renal corpuscle is a multi-compartment unit of kidney morphology which is important for normal ultrafiltration of blood. Its structure is perturbed during ontogeny, disease and experimental manipulation. Transmission electron microscopy and second-order stereological tools (cross covariance and cross correlation functions) were used to examine 3-D spatial interactions between the main tissue compartments (glomerular capillaries, podocytes, mesangium, urinary space) of the renal corpuscle in normal adult rats. Volume densities, covariance and correlation functions were estimated by counting

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Da, Yi, K. Akalya, Tanusya Murali, et al. "Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury." Current Drug Metabolism 20, no. 8 (2019): 656–64. http://dx.doi.org/10.2174/1389200220666190711114504.

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Background: : Drug-induced Acute Kidney Injury (AKI) develops in 10-15% of patients who receive nephrotoxic medications. Urinary biomarkers of renal tubular dysfunction may detect nephrotoxicity early and predict AKI. Methods:: We prospectively studied patients who received aminoglycosides, vancomycin, amphotericin, or calcineurin inhibitors, and collected their serial urine while on therapy. Patients who developed drug-induced AKI (fulfilling KDIGO criteria) were matched with non-AKI controls in a 1:2 ratio. Their urine samples were batch-analyzed at time-intervals leading up to AKI onset; th

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Gilbertson-White, Stephanie, Sanvesh Srivastava, Yunyi Li, et al. "Multimorbidity, cancer, and symptoms: Using electronic health record data to cluster patients in multimorbidity phenotypes." Journal of Clinical Oncology 37, no. 31_suppl (2019): 130. http://dx.doi.org/10.1200/jco.2019.37.31_suppl.130.

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130 Background: Cancer-related symptoms are associated with decreased quality of life, increased health care utilization, and shorter life expectancy. There is limited understanding of how multiple chronic conditions (MCC) contribute to variability in symptoms experienced in the context of cancer. Data mining the EHR will allow us to use real clinical data to identify multimorbidity phenotypes based on the clinical similarity of patients. Purpose of this study is to identify distinct subgroups of patients based on the MCC and cancer diagnoses and describe differences across these subgroups. Me

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Ascher, Simon B., Rebecca Scherzer, Michelle M. Estrella, et al. "Association of Urinary Biomarkers of Kidney Injury with Estimated GFR Decline in HIV-Infected Individuals following Tenofovir Disoproxil Fumarate Initiation." Clinical Journal of the American Society of Nephrology 13, no. 9 (2018): 1321–29. http://dx.doi.org/10.2215/cjn.01700218.

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Background and objectivesTenofovir disoproxil fumarate (tenofovir) is associated with elevated concentrations of biomarkers of kidney damage and dysfunction in individuals with HIV. The relationship of these kidney biomarkers with longitudinal kidney function decline is unknown.Design, setting, participants, & measurementsWe evaluated associations of 14 urinary biomarkers of kidney injury with changes in eGFR among 198 men and women with HIV who initiated tenofovir between 2009 and 2015 in the Multicenter AIDS Cohort Study and Women’s Interagency HIV Study. Urinary biomarkers included albu

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Pais, Gwendolyn M., Jiajun Liu, Sean N. Avedissian, et al. "Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model." Journal of Antimicrobial Chemotherapy 75, no. 5 (2020): 1228–36. http://dx.doi.org/10.1093/jac/dkz563.

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Abstract Background Vancomycin and piperacillin/tazobactam are reported in clinical studies to increase acute kidney injury (AKI). However, no clinical study has demonstrated synergistic toxicity, only that serum creatinine increases. Objectives To clarify the potential for synergistic toxicity between vancomycin, piperacillin/tazobactam and vancomycin + piperacillin/tazobactam treatments by quantifying kidney injury in a translational rat model of AKI and using cell studies. Methods (i) Male Sprague–Dawley rats (n = 32) received saline, vancomycin 150 mg/kg/day intravenously, piperacillin/taz

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Yusenko, Elena, Kirill Yusenko, Ilya Korolkov, et al. "High-throughput powder X-ray diffraction, IR-spectroscopy and ion chromatography analysis of urinary stones: A comparative study." Open Chemistry 11, no. 12 (2013): 2107–19. http://dx.doi.org/10.2478/s11532-013-0335-z.

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AbstractThe instrumental qualitative analysis of urinary stones is a critical step in clinical practice and urological research. A powder X-ray diffraction, IR-spectroscopy and ion chromatography have been applied for the qualitative analysis of 20 urinary stones. Suggestions for a sample preparation and an optimal measurement strategy were formulated. The main difficulties for the powder X-ray diffraction qualitative analysis are a limiting amount of the sample and a preferential orientation of crystals, both issues should be minimized by the special sample preparation. Urinary stones samples

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Woszczyło, Martyna, Paweł Pasikowski, Sankarganesh Devaraj, et al. "Urinary Proteins of Female Domestic Dog (Canis familiaris) during Ovarian Cycle." Veterinary Sciences 10, no. 4 (2023): 292. http://dx.doi.org/10.3390/vetsci10040292.

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The presence and identity of non-volatile chemical signals remain elusive in canines. In this study, we aim to evaluate the urinary proteins of female domestic dogs in the estrus and anestrus phases to evidence the presence of non-volatile chemical signals and to elucidate their identities. We collected urine samples from eight female dogs in the estrus and anestrus phases. A total of 240 proteins were identified in the urine samples using liquid chromatography–mass spectrometry (LC–MS analysis). The comparison of the proteins revealed a significant difference between the estrus and anestrus u

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Romano, Megan E., Jessie P. Buckley, Xiuhong Li, et al. "Changes in urinary concentrations of contemporary and emerging chemicals in commerce during the COVID-19 pandemic: Insights from the Environmental influences on Child Health Outcomes (ECHO) program." PLOS ONE 20, no. 1 (2025): e0317358. https://doi.org/10.1371/journal.pone.0317358.

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Previous research indicates that the COVID-19 pandemic catalyzed alterations in behaviors that may impact exposures to environmental endocrine-disrupting chemicals. This includes changes in the use of chemicals found in consumer products, food packaging, and exposure to air pollutants. Within the Environmental influences on Child Health Outcomes (ECHO) program, a national consortium initiated to understand the effects of environmental exposures on child health and development, our objective was to assess whether urinary concentrations of a wide range of potential endocrine-disrupting chemicals

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Van den Ende, Mauro, Laure Van de Steen, Karel Everaert, François Hervé, and George Bou Kheir. "Exploring Childhood Lower Urinary Tract Symptoms (LUTS), Urinary Tract Infections (UTIs) and the Microbiome—A Systematic Review." Life 15, no. 5 (2025): 730. https://doi.org/10.3390/life15050730.

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Pediatric lower urinary tract symptoms (LUTS) are influenced by age and coexist with nocturnal enuresis (NE) and bladder-bowel dysfunction (BBD). Urinary tract infections (UTIs) are common and linked to LUTS, though the causal relationship remains unclear. This systematic review aims to analyze microbiome alterations in pediatric LUTS and UTIs. Methods: A systematic review was conducted following PRISMA guidelines. PubMed, Embase, and CINAHL databases were searched for studies analyzing gut and urinary microbiomes in pediatric patients with LUTS and UTIs. Quality assessment was performed using

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Blümlhuber, Annika, Dennis Freuer, Nina Wawro, Florian Rohm, Christine Meisinger, and Jakob Linseisen. "Association Between Habitual Dietary Intake and Urinary Metabolites in Adults—Results of a Population-Based Study." Metabolites 15, no. 7 (2025): 441. https://doi.org/10.3390/metabo15070441.

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Background: Chronic non-communicable diseases (NCDs) are a major global health challenge, with unhealthy diets contributing significantly to their burden. Metabolomics data offer new possibilities for identifying nutritional biomarkers, as demonstrated in short-term intervention studies. This study investigated associations between habitual dietary intake and urinary metabolites, a not well-studied area. Methods: Data were available from 496 participants of the population-based MEIA study. Linear and median regression models examined associations between habitual dietary intake and metabolites

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Lysak, Nicholas, Ashkan Ebadi, Sabyasachi Bandyopadhyay, et al. "Unsupervised Machine Learning Analysis of Urinary Transcriptome Reveals Distinct Genotypic Clustering in Surgical Sepsis." Journal of the American College of Surgeons 225, no. 4 (2017): S66—S67. http://dx.doi.org/10.1016/j.jamcollsurg.2017.07.137.

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Startsev, V. Yu, and V. A. Dudarev. "Assessment of novel biomarkers of renal dysfunction associated with lower urinary tract symptoms in men with benign prostatic hyperplasia." Urology Herald 12, no. 5 (2024): 33–44. https://doi.org/10.21886/2308-6424-2024-12-5-33-44.

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Introduction. The problem of diagnostics and treatment of patients with complex lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) remains highly relevant. Clinical diagnostic methods do not always allow timely prediction of changes in renal, upper and lower urinary tract function with different types of treatment intervention. The search for potential biomarkers allowing minimally invasive assessment of the bladder and renal function condition seems to be a promising direction of scientific research.Objective. To identify potential urine and serum biomarkers

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Odun-Ayo, Frederick, Jagidesa Moodley, and Thajasvarie Naicker. "Urinary clusterin and glutathione-s-transferase levels in HIV positive normotensive and preeclamptic pregnancies." Hypertension in Pregnancy 37, no. 3 (2018): 160–67. http://dx.doi.org/10.1080/10641955.2018.1498881.

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Boardman, S., M. Coffey, K. Taylor, et al. "WS04.5 Urinary clusterin in children with cystic fibrosis: a novel biomarker of lung disease?" Journal of Cystic Fibrosis 19 (June 2020): S7—S8. http://dx.doi.org/10.1016/s1569-1993(20)30187-9.

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Shabayek, Marwa I., Ola M. Sayed, Hanan A. Attaia, Heba A. Awida, and Hamdy Abozeed. "Diagnostic Evaluation of Urinary Angiogenin (ANG) and Clusterin (CLU) as Biomarker for Bladder Cancer." Pathology & Oncology Research 20, no. 4 (2014): 859–66. http://dx.doi.org/10.1007/s12253-014-9765-y.

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Soukup, Viktor, Marta Kalousová, Otakar Capoun, et al. "Panel of Urinary Diagnostic Markers for Non-Invasive Detection of Primary and Recurrent Urothelial Urinary Bladder Carcinoma." Urologia Internationalis 95, no. 1 (2015): 56–64. http://dx.doi.org/10.1159/000368166.

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Objectives: To determine the combination of urinary protein markers for noninvasive detection of primary and recurrent urothelial bladder carcinomas. Methods: Urinary concentrations of 27 biomarkers (NSE, ATT, AFABP, Resistin, Midkine, Clusterin, Uromodulin, ZAG2, HSP27, HSP 60, NCAM1/CD56, Angiogenin, Calreticulin, Chromogranin A, CEACAM1, CXCL1, IL13Ra2, Progranulin, VEGFA, CarbAnhydIX, Annexin-V, TIM4, Galectin1, Cystatin B, Synuclein G, ApoA1 and ApoA2) were assessed by enzyme-linked immunosorbent assay or by electrochemiluminiscence immunoassay. Results: During the primary diagnostics, a

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Gu, Yi-Zhong, Larry Handt, Katerina Vlasakova, et al. "Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling." Toxicologic Pathology 50, no. 1 (2021): 35–46. http://dx.doi.org/10.1177/01926233211049171.

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Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory study to directly compare the low-grade kidney injury monitoring performance of serum safety biomarkers, novel urine safety biomarkers, microscopic histopathology and targeted gene expression alterations in kidney biopsy specimens in rhesus monkeys treated with tobramycin. Targeted gene expression increases were observed in the kidney biopsy samples and whole kidney sections for kidney injury molecule 1 ( KIM-1), clusterin ( CLU), osteopontin ( OPN) messenger RNA transcripts.

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Carestia, Elena, Fabrizio Di Giuseppe, Mohammad Kazemi, et al. "Significant Changes in Low-Abundance Protein Content Detected by Proteomic Analysis of Urine from Patients with Renal Stones After Extracorporeal Shock Wave Lithotripsy." Biology 14, no. 5 (2025): 482. https://doi.org/10.3390/biology14050482.

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Extracorporeal shock wave lithotripsy (ESWL), although a highly effective method for the treatment of kidney stones, can cause significant kidney damage. Since urinary protein composition directly reflects kidney function, proteomic analysis of this fluid may be useful to identify changes in protein levels induced by patient exposure to ESWL as a sign of kidney damage. To this end, we collected urine samples from 80 patients with nephrolithiasis 2 h before and 24 h after exposure to ESWL, which were concentrated and subsequently processed with a commercially available enrichment method to extr

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Rhodes, Nathaniel J., Walter C. Prozialeck, Thomas P. Lodise, et al. "Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats." Antimicrobial Agents and Chemotherapy 60, no. 10 (2016): 5742–51. http://dx.doi.org/10.1128/aac.00591-16.

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ABSTRACTVancomycin has been associated with acute kidney injury (AKI). However, the pharmacokinetic/toxicodynamic relationship for AKI is not well defined. Allometrically scaled vancomycin exposures were used to assess the relationship between vancomycin exposure and AKI. Male Sprague-Dawley rats received clinical-grade vancomycin in normal saline (NS) as intraperitoneal (i.p.) injections for 24- to 72-h durations with doses ranging 0 to 200 mg/kg of body weight divided once or twice daily. Urine was collected over the protocol's final 24 h. Renal histopathology was qualitatively scored. Urina

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