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Tesis sobre el tema "ABCA13"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 10 de febrero de 2022

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1

Knight, Helen Miranda. "Candidate gene studies in psychiatric illness." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/6508.

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Schizophrenia, bipolar disorder and major depression are common, heritable neuropsychiatric conditions and yet the source of the inherited risk remains largely unknown. This thesis focuses on two complementary strategies for identifying and characterising the genetic component of these illnesses: homozygosity mapping in consanguineous pedigrees, and genetic and neurobiological investigations of candidate genes identified by the analysis of structural chromosomal abnormalities carried by patients with psychiatric diagnoses. In a family of a cousin marriage, five of six offspring presented with

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2

Tomioka, Maiko. "Expression of ABCA13 in the brain and the effect of neurological disorder-related SNPs on the function." Kyoto University, 2013. http://hdl.handle.net/2433/175051.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第17622号<br>農博第1984号<br>新制||農||1010(附属図書館)<br>学位論文||H25||N4743(農学部図書室)<br>30388<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授植田充美, 教授阪井康能<br>学位規則第4条第1項該当

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3

Davids, Muneera. "Single nucleotide polymorphism association studies of ABCA13 and ABHD11 genes and the bioinformatics analysis of the autism candidate genes localized on chromosome 7." University of the Western Cape, 2016. http://hdl.handle.net/11394/4977.

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Magister Scientiae - MSc<br>Autism, Aspergers Syndrome and Pervasive Developmental Delay-Not Otherwise Specified (PDD-NOS), among others, fall under an umbrella of disorders known as Autism Spectrum Disorder. Twin studies show that autism is a highly heritable disorder. More than 100 genes have been implicated in the aetiology of autism, each of which is involved in numerous biological processes and a variety of molecular interactions. William-Beuren syndrome is a multisystem developmental disorder caused by the deletion of contiguous genes at the 7q11.23 position. The aims of this study were

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4

Teixeira, Mayza Dalcin. "Estudo da associação de polimorfismos dos genes FTO, ABCA1, ABCA7 e ABCG1 com marcadores de obesidade e perfil lipídico em mulheres obesas." reponame:Repositório Institucional da UFPR, 2017. http://hdl.handle.net/1884/47563.

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Orientadora : Profª. Drª. Lupe Furtado-Alle<br>Coorientadora : Drª Luciane Viater Tureck<br>Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Genética. Defesa: Curitiba, 31/03/2017<br>Inclui referências : f. 85-88<br>Resumo: A maioria dos casos de obesidade e de dislipidemias possui origem complexa, pois é resultante da interação entre fatores genéticos e ambientais. Diversos genes têm sido relacionados com a susceptibilidade a estas doenças, incluindo variantes alélicas dos genes FTO, ABCA1, ABCA7 e ABCG1. Desse modo, o objetiv

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5

Matsuda, Akihiro. "(24S)-Hydroxycholesterol efflux from neuronal cells by ABC proteins." Kyoto University, 2014. http://hdl.handle.net/2433/185211.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第17986号<br>農博第2033号<br>新制||農||1019(附属図書館)<br>学位論文||H26||N4811(農学部図書室)<br>80830<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授植田充美, 教授三芳秀人<br>学位規則第4条第1項該当

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6

Nascimento, Gabrielle Araújo do. "Avaliação do efeito de polimorfismos nos genes FTO, ABCA1, ABCA7 e ABCG1 sobre indicadores de obesidade e dislipidemias em crianças e adolescentes submetidos a treinamentos físico." reponame:Repositório Institucional da UFPR, 2017. http://hdl.handle.net/1884/47393.

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Orientadora : Profª Drª Luciane Viater Tureck<br>Coorientadora : Profª Drª Lupe Furtado Alle<br>Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Genética. Defesa: Curitiba, 27/03/2017<br>Inclui referências<br>Resumo: A obesidade e as dislipidemias geralmente estão associadas, e na maior parte dos casos possuem origem complexa, sendo decorrentes da interação entre os fatores ambientais e fatores genéticos. Dentre os fatores genéticos já conhecidos encontram-se genes relacionados ao metabolismo, como o gene FTO (Fat Mass and Obes

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7

Rodrigues, Lucas Campos de Sá. "Estudo da expressão dos genes de resistência a múltiplas drogas ABCB1, ABCC1 e ABCG2, em cães com linfoma multicêntrico, submetidos a três diferentes protocolos de tratamento antineoplásico." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-08102012-141346/.

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Um dos principais desafios no tratamento quimioterápico em seres humanos e animais é a resistência que as células neoplásicas apresentam, sendo esse mecanismo responsável por falhas no tratamento e recidivas da doença. A resistência pode ser intrínseca ou adquirida e ocorre em função da expressão de transportadores de membrana ABC, como a glicoproteína P (ABCB1/MDR), proteínas de resistência a múltiplas drogas (ABCC1/MRP) e proteína de resistência do câncer de mama (ABCG2/BCRP). O linfoma é a neoplasia hematopoiética mais comum em cães, altamente responsiva à quimioterapia, mas que recidiva du

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8

Plazzo, Anna Pia. "Influence of ABCA1 and ABCA7 on the lipid microenvironment of the plasma membrane." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15953.

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Der ABC-Transporter ABCA1 ist unmittelbar in die zelluläre Lipidhomeostasie einbezogen, in dem er die Freisetzung von Cholesterol an plasmatische Rezeptoren, wie ApoA-I, vermittelt. Trotz intensiver Untersuchungen ist dieser molekulare Mechanismus nicht verstanden. Verschiedene Studien deuten daraufhin, dass durch die Aktivität von ABCA1 bedingte Veränderungen in der Lipidphase der äußeren Hälfte der Plasmamembran (PM) wichtig für die Freisetzung des Cholesterols sind. In der vorliegenden Arbeit wird die Lipidumgebung von ABCA1 in der PM lebender Säugetierzellen unter Anwendung der Fluoreszen

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9

Brüggmann, Nina [Verfasser]. "Untersuchungen zum ABCA1-/ABCG1-vermittelten Cholesterin-Efflux in humanen Kontroll- und Tangierfibroblasten / Nina Brüggmann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228861153/34.

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10

中塔, 充宏. "ABCタンパク質による脳内脂質輸送の生理的役割". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263711.

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11

Monzel, Judith Verena [Verfasser]. "Regulation der Cholesteroltransporter ABCA1 und ABCG1 im Kontext der Doxorubicin-induzierten Kardiotoxizität / Judith Verena Monzel." Greifswald : Universitätsbibliothek Greifswald, 2017. http://d-nb.info/1143131673/34.

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12

Zago, Vanessa Helena de Souza 1984. "Estudo molecular dos genes ABCA1, ABCG1, ABCG5, ABCG8 e SCARB1 em amostra populacional brasileira assintomática." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312594.

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Orientadores: Eliana Cotta de Faria, Helena Coutinho Franco de Oliveira, Daniel Zanetti Scherrer<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T20:49:38Z (GMT). No. of bitstreams: 1 Zago_VanessaHelenadeSouza_D.pdf: 5059555 bytes, checksum: 854d9d1d1674a14d2ebcf5798acc31b3 (MD5) Previous issue date: 2015<br>Resumo: Dado o importante papel desempenhado pelos transportadores ATP binding cassete A1 (ABCA1), G1 (ABCG1), G5 (ABCG5), G8 (ABCG8) e pelo scavenger receptor class B type I (SR-BI) para a homeostase corpóre

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13

Moraes, Ana Carolina Rabello de. "Estudo da associação de genes e proteínas de resistência a múltiplos fármacos (abcb1/ABCB1, abcc1/ABCC1 e lrp/LRP) com marcadores moleculares em pacientes portadores de leucemias agudas." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/107623.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.<br>Made available in DSpace on 2013-12-06T00:39:31Z (GMT). No. of bitstreams: 1 319055.pdf: 3105190 bytes, checksum: f462b93c678d315794c7ff809ddb0b6c (MD5) Previous issue date: 2013<br>Menos de 45% dos portadores de leucemias agudas (LAs) sobrevivem cinco anos após o diagnóstico. O insucesso no tratamento relaciona-se, principalmente, à resistência à quimioterapia. O mecanismo mais comumente implicado na resistência a múltiplos fármacos (MDR) é a

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14

Gerloff, Thomas. "Die Bedeutung der ABC-Transportsysteme ABCB1 und Abcb11 in der Arzneimitteltherapie und bei cholestatischen Lebererkrankungen." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972571264.

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15

Rajpopat, Shefali. "Harlequin ichthyosis and ABCA12." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3159.

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Harlequin ichthyosis (HI), a rare severe form of congenital ichthyosis is caused by recessive mutations in the ABCA12 gene. At birth, affected neonates have widespread, grossly thickened skin, separated by deep red fissures, bilateral ectropion, eclabium and a rudimentary nose and ears. Previously, most babies died shortly after birth but with improved neonatal care and the early introduction of oral retinoids, there is now a cohort of HI survivors. ABCA12 mutation analysis was performed and bi-allelic mutations were identified in 14 out of 17 cases, 9 of which were novel. In one consanguineou

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16

Zhang, Anja Ziwen. "Sumoylierung und Targeting von ABCA3." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-146702.

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17

Kang, Martin Hubert. "Post-transcriptional regulation of ABCA1." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43655.

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Epidemiological studies consistently demonstrate an inverse relationship between HDL levels and cardiovascular disease (CVD), independent of LDL and triglyceride levels. Due to the crucial role ABCA1 plays in HDL biogenesis, increasing ABCA1 expression is considered an attractive strategy to increase plasma HDL levels. In this thesis we attempt to identify novel post-transcriptional and post-translational mechanisms that regulate ABCA1 expression and/or function. Prior to translation, ABCA1 protein expression is regulated by non-coding RNA molecules known as microRNAs which bind and inhibit tr

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18

Chambenoit, Olivier. "ABCA1 et l'homéostasie du cholestérol cellulaire." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22023.

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19

Stefan, Katja [Verfasser]. "Etablierung und Anwendung unterschiedlicher kolorimetrischer Detektionsmethoden zur Aktivitätsbestimmung von Modulatoren der ABC-Transporter ABCB1, ABCC1 und ABCG2 / Katja Stefan." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1221668986/34.

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20

Sahrhage, Tim Oliver [Verfasser], and Marc [Akademischer Betreuer] Freichel. "Verteilung der ATP-binding-cassette Transporter ABCG1, ABCG2, ABCB9 und ABCE1 in murinem Hodengewebe / Tim Oliver Sahrhage. Betreuer: Marc Freichel." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1053725469/34.

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21

Huppmann, Marceline. "Lungenmechanische Charakterisierung von heterozygoten ABCA3-Knockout-Mäusen." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-133099.

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22

Nagao, Kojiro. "Mechanism of high-density lipoprotein formation by ABCA1." Kyoto University, 2010. http://hdl.handle.net/2433/120486.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第15443号<br>農博第1828号<br>新制||農||981(附属図書館)<br>学位論文||H22||N4542(農学部図書室)<br>27921<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授間藤徹, 教授阪井康能<br>学位規則第4条第1項該当

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23

Do, Tuan Minh. "Intégrité de la barrière hémato-encéphalique et transport du peptide bêta-amyloïde dans la maladie d'Alzheimer." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114839.

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Récemment, des études menées chez des patients atteints de la maladie d’Alzheimer (MA) suggèrent un rôle important de la clairance cérébrale des peptides bêta-amyloïde (Abeta) dans la physiopathologie de la MA. Les échanges de peptide Abeta entre le cerveau et le sang peuvent se faire à travers la barrière hémato-encéphalique (BHE). De nombreux transporteurs sont exprimés au niveau de la BHE, telles les protéines ABC (ATP-Binding Casette) et SLC (Solute Carriers). Il a été montré que l’influx du peptide Abeta à travers la BHE était partiellement médié par le récepteur RAGE (Receptor for Advanc

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24

Nandi, Shilpi. "The involvement of membrane vesiculation in ABCA1 mediated efflux." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27897.

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The mechanism of ATP binding cassette transporter A1 (ABCA1) mediated cholesterol efflux is presently unclear. Cells expressing ABCA1 reported to display distinctive membrane-protrusion-like morphology and apoA1 was also seen to bind to those structures. We hypothesized that cholesterol efflux may be in part originated from membrane shedding through membrane vesiculation and therefore may rely on relatively flexible plasma membrane. We tested several reagents known to modulate membrane fluidity and found that cholesterol efflux is indeed inversely correlated with membrane rigidity. Additionall

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25

Schulte, Daniel. "Molekulare und funktionelle Charakterisierung von Targetingsequenzen im humanen ABCA3-Protein." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-92875.

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26

Jennelle, Lucas Trent. "Contribution of Calnexin to HIV-1 Nef effects on ABCA1." Thesis, The George Washington University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3557581.

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<p> HIV-infected patients are at increased risk of developing atherosclerosis, in part due to an altered HDL profile exacerbated by downmodulation and impairment of ATP-Binding Cassette Transporter A1 (ABCA1) activity by the HIV-1 protein Nef. Nef has been shown to increase delivery of cholesterol to lipid rafts, sites of viral assembly and egress, by inhibition of ABCA1 cholesterol efflux functionality and reduction of ABCA1 protein levels through lysosomal degradation. Important mechanistic details of ABCA1 inactivation and degradation by Nef, and whether these two processes are intimately

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27

Höppner, Stefanie [Verfasser], and Matthias [Akademischer Betreuer] Griese. "Funktionelle Analyse des ABCA3 Transporters / Stefanie Höppner ; Betreuer: Matthias Griese." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1206878231/34.

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28

Patel, Dipesh C. "Glycaemic influences on the ATP-binding cassette transporter A1 (ABCA1)." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6864.

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Increased glucose levels are associated with increased risk of vascular disease. The risk is elevated 2-4 fold in type 2 diabetes and there is a positive relationship between glucose (or HbA1c) levels and vascular disease in the general population. We tested the hypothesis that there is a glycaemia-mediated impairment of reverse cholesterol transport (RCT) by studying an early key step, notably the expression and activity of the ATP binding cassette transporter-A1 (ABCA1). This protein exports cellular cholesterol to apolipoprotein A1 (ApoA-I), thereby forming nascent HDL. In this thesis, it i

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Moraes, Ana Carolina Rabello de. "Importância da investigação de proteínas de resistência ABCB1, ABCC1 e LRP e da proteína antiapoptótica Bcl-2 no diagnóstico e no prognóstico de leucemias agudas." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/93790.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010<br>Made available in DSpace on 2012-10-25T03:26:24Z (GMT). No. of bitstreams: 1 279884.pdf: 7471394 bytes, checksum: 49ecffa5cacc5208c3b1840fdef5866c (MD5)<br>A resistência a múltiplas drogas é uma das maiores causas para a falha do tratamento das leucemias agudas (LA). A resistência adquirida ou intrínseca a múltiplas drogas (MDR) depende de muitas variáveis biológicas e é principalmente caracterizada pela resistência cruzada a uma ampla vari

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Karcher, Annette. "Struktur von ABCE1." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-72198.

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31

Lee, Jee Yeon. "ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20519.

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ABCA1 is a key plasma membrane protein required for the efflux of cellular cholesterol to extracellular acceptors, particularly to apoA-I. This process is essential to maintain cholesterol homeostasis in the body. The detailed molecular mechanisms, however, are still insufficiently understood. Also, the molecular identity of ABCA1, i.e. channel, pump or flippase, remains unknown. In this study we analyzed the extracellular ATP levels in the medium of ABCA1-expressing BHK cells and RAW macrophages and compared them to the medium of relevant non-expressing cells. We found that the extracellular

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Kahraman, Emine. "Rolle von ABCA1 auf das HDL-induzierte Recycling von Chylomikronen Bestandteilen /." Hamburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252993.

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Zhang, Anja Ziwen Verfasser], and Andreas [Akademischer Betreuer] [Holzinger. "Sumoylierung und Targeting von ABCA3 / Anja Ziwen Zhang. Betreuer: Andreas Holzinger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1026012333/34.

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Zhang, Anja Ziwen [Verfasser], and Andreas [Akademischer Betreuer] Holzinger. "Sumoylierung und Targeting von ABCA3 / Anja Ziwen Zhang. Betreuer: Andreas Holzinger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1026012333/34.

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35

Sims, Lynn. "Biochemical Studies of ABCE1." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5501.

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The growth and survival of all cells require functional ribosomes that are capable of protein synthesis. The disruption of the steps required for the function of ribosomes represents a potential future target for pharmacological anti-cancer therapy. ABCE1 is an essential Fe-S protein involved in ribosomal function and is vital for protein synthesis and cell survival. Thus, ABCE1 is potentially a great therapeutic target for cancer treatment. Previously, cell biological, genetic, and structural studies uncovered the general importance of ABCE1, although the exact function of the Fe-S cluster

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36

Genvigir, Fabiana Dalla Vecchia. "Estudo da expressão gênica e de polimorfismos do gene ABCA1 em indivíduos sob terapia hipolipemiante." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-17042008-151909/.

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A ATP-binding cassette transporter A1 (ABCA1) é uma proteína transmembrana responsável pelo efluxo celular de colesterol e fosfolipídeos, que é um passo essencial para o transporte reverso do colesterol e para a biogênese da HDL. Polimorfismos do gene ABCA1 foram associados com risco de doença arterial coronariana, variações no perfil lipídico e diferenças na resposta a fármacos hipolipemiantes. Com a finalidade de avaliar os efeitos de polimorfismos do ABCA1 sobre a expressão gênica e a resposta a vastatinas, foram selecionados indivíduos normolipidemicos (NL, n=143) e hipercolesterolêmicos (

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Hrusovar, Natalie. "Beeinflussung des LXR Alpha-abhängigen Cholesterintransporters ABCA1 durch Stigmasterol und seine Oxyderivate." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-97539.

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Hrusovar, Natalie. "Beeinflussung des LXR Alpha-abhängigen Cholesterintransporters ABCA1 durch Stigmasterol und seine Oxyderivate." kostenfrei, 2009. http://edoc.ub.uni-muenchen.de/9753/.

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39

Schindlbeck, Ulrike [Verfasser], and Matthias [Akademischer Betreuer] Griese. "Charakterisierung neuer Missense Mutationen im Lipidtransporter ABCA3 / Ulrike Schindlbeck ; Betreuer: Matthias Griese." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/119981640X/34.

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40

Schicker, Maresa. "Die Charakterisierung der Funktion des Lipidtransporters ABCA3 in der Milchdrüse (am Mausmodell)." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-172584.

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ABCA3 ist als Phospholipidtransporter der ABC-Transporterfamilie wesentlich an der Synthese von Lungensurfactant beteiligt. Diese wichtige Rolle von ABCA3 in der Lunge ist mittlerweile bekannt und wird weiterhin näher erforscht. Des Weiteren wird ABCA3 auch in anderen Geweben exprimiert, darunter Leber, Niere, Gehirn [Stahlman et al. 2007]. ABCA3 wurde daneben auch in humanem Milchdrüsengewebe entdeckt und stellt in Mammakarzinomen einen Marker für eine gute Prognose dar [Schimanski 2010]. In der murinen Milchdrüse ist die Abca3-Expression molekularbiologisch auf Ebene der mRNA nachgewiesen

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Zarubica, Ana. "Influence du transporteur ABCA1 sur le microenvironnement lipidique de la membrane plasmique." Aix-Marseille 2, 2009. http://theses.univ-amu.fr.lama.univ-amu.fr/2009AIX22025.pdf.

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Le transporteur ABCA1 est impliqué dans le transfert des phospholipides et du cholestérol vers Apo A-I sur la membrane plasmique cellulaire. Comme ABCA1 est un transporteur des lipides, nous avons examiné son effet sur le microenvironnement lipidique de la membrane. Nous avons démontré que l'activité ATP-ase d'ABCA1 modifie sa répartition dans les radeaux lipidiques, ainsi que la répartition d’autres protéines de la membrane comme le récepteur de transferrine (TfR), la dynamique cinétique de TfR et réduit l’endocytose de TfR. Nous avons montré par des méthodes biophysiques, cationic sensors et

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Azuma, Yuya. "Studies on intracellular trafficking and degradation of ABCA1 involved in HDL formation." Kyoto University, 2009. http://hdl.handle.net/2433/126527.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第14841号<br>農博第1781号<br>新制||農||974(附属図書館)<br>学位論文||H21||N4481(農学部図書室)<br>27247<br>UT51-2009-F483<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授三芳秀人<br>学位規則第4条第1項該当

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Yu, Zhao. "Effect of sphingomyelin on the lipid-export activities of ABCA1 and ABCB4." Kyoto University, 2015. http://hdl.handle.net/2433/200507.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19241号<br>農博第2138号<br>新制||農||1036(附属図書館)<br>学位論文||H27||N4945(農学部図書室)<br>32240<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授矢﨑一史, 教授栗原達夫<br>学位規則第4条第1項該当

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Hozoji, Masako. "Post-translational modification and regulation of ABCA1 involved in cellular cholesterol homeostasis." Kyoto University, 2009. http://hdl.handle.net/2433/126528.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第14842号<br>農博第1782号<br>新制||農||974(附属図書館)<br>学位論文||H21||N4482(農学部図書室)<br>27248<br>UT51-2009-F484<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授三芳秀人<br>学位規則第4条第1項該当

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Brunham, Liam Robert. "The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/400.

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The ATP-binding cassette transporter, sub-family A, member 1 (ABCA1) mediates the major pathway for cholesterol exit from non-hepatic cells and thereby controls the rate-limiting step in the biogenesis of high density lipoprotein (HDL) particles. In humans,ABCA1 deficiency results in Tangier disease, characterized by low levels of HDL cholesterol, cellular cholesterol accumulation and increased risk for atherosclerosis. More than 100 coding variants have been described in the ABCA1 gene. We attempted to understand how both naturally occurring and engineered mutations in ABCA1 impact its role i

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Chigusa, Yoshitsugu. "Reduced ABCA1 expression and low Nrf2 activation due to decreased lectin-like oxidized LDL receptor 1 (LOX-1)in the placenta are involved in preeclampsia." Kyoto University, 2014. http://hdl.handle.net/2433/188637.

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Thajam, Deirdre. "The role of multidrug resistance proteins in determining fetal susceptibility to drugs of misuse." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-multidrug-resistance-proteins-in-determining-fetal-susceptibility-to-drugs-of-misuse(85fef852-5e19-4700-950e-753d85fad88c).html.

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Background: Negative outcomes from fetal exposure to maternal dug use include Neonatal Abstinence Syndrome (NAS) and altered development, the unpredictability of which suggests a biological element as yet not accounted for. The manner in which the human placenta protects the fetus from xenobiotics such as drugs of misuse is not completely characterised. However, Adenosine Triphosphate Binding Cassette (ABC) transporters in placentae have demonstrated their ability to efflux xenobiotics away from the fetal vascular compartment leading to lower concentrations than in the maternal compartment and

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Weichert, Nina. "Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-137380.

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Huppmann, Marceline [Verfasser], and Andreas W. [Akademischer Betreuer] Flemmer. "Lungenmechanische Charakterisierung von heterozygoten ABCA3-Knockout-Mäusen / Marceline Huppmann. Betreuer: Andreas W. Flemmer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015169775/34.

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Landry, Yves D. "ABCA1 expression disrupts lipid raft plasma membrane microdomains through its ATPase-related functions." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27871.

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The ATP-binding cassette transporter A1 (ABCA1) is known to mediate cholesterol efflux to lipid-poor apolipoprotein A-I. In addition, ABCA1 has been shown to influence functions of the plasma membrane, such as endocytosis and phagocytosis. Here, we report that ABCA1 expression results in a significant redistribution of plasma membrane cholesterol and sphingomyelin from lipid rafts to non-raft regions. Caveolin, a lipid raft/caveolae protein marker, also redistributes from punctate, caveolae-like structures to the general area of the plasma membrane upon expression of ABCA1. Furthermore, we obs

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