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Tesi sul tema "Metastáza"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 25 aprile 2022

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1

Nohel, Michal. "Analýza časového vývoje léčených nádorů páteře v CT datech." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442581.

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Abstract (sommario):
This diploma thesis is focused on time-development analysis of treated lesion in CT data. The theoretical part of the thesis deals with the anatomy, physiology, and pathophysiology of the spine and vertebral bodies. It further describes diagnostic and therapeutic options for the detection and treatment of spinal lesions. It contains an overview of the current state of usage of time-development analysis in oncology. The problems of the available databases are discussed and new databases are created for subsequent analysis. Futhermore, the methodology of time-development analysis according to th
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2

Chmelík, Jiří. "Metody detekce, segmentace a klasifikace obtížně definovatelných kostních nádorových lézí ve 3D CT datech." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-433066.

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Abstract (sommario):
The aim of this work was the development of algorithms for detection segmentation and classification of difficult to define bone metastatic cancerous lesions from spinal CT image data. For this purpose, the patient database was created and annotated by medical experts. Successively, three methods were proposed and developed; the first of them is based on the reworking and combination of methods developed during the preceding project phase, the second method is a fast variant based on the fuzzy k-means cluster analysis, the third method uses modern machine learning algorithms, specifically deep
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3

Ivana, Mijatov. "Uticaj dubine invazije oralnog planocelularnog karcinoma na pojavu metastaza u limfnim čvorovima vrata." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110690&source=NDLTD&language=en.

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Abstract (sommario):
Oralni karcinom je po učestalosti šesta najčešća maligna bolest u svetu čija incidenca varira u različitim geografskim područjima. Predstavlja 5% svih novootkrivenih malignih tumora godišnje i čini 14% svih malignih tumora glave i vrata. Pod oralnim karcinom podrazumevamo planocelularni karcinom obzirom na činjenicu da on čini preko 90% malignih tumora oralne lokalizacije, dok se u manjem procentu javljaju drugi tumori (maligni tumori malih pljuvačnih žlezda, limfomi, mezenhimni tumori). Oralni karcinom podrazumeva karcinome koji se javljaju u sledećim anatomskim regijama:
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4

Nemanja, Petrović. "Terapijski i prognostički značaj gustine tumorskih pupoljaka kod reseciranih sinhronih i metahronih jetrenih metastaza kolorektalnog karcinoma." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114131&source=NDLTD&language=en.

Testo completo
Abstract (sommario):
Tumorsko pupljenje (TP) u karcinomu je morfološki fenomen koji predstavlja pojavu pojedinačnih ili malih grupa dediferentovanih tumorskih ćelija koje se na invazivnom frontu karcinoma odvajaju od glavne tumorske mase. Kod metastatskog kolorektalnog karcinoma (KRK) definitivno ne možemo odrediti pravi doprinos TP. Cilj je bio da se ispita terapijski patohistološki odgovor na primenjeni hemioterapijski režim, prognostički i nezavisni negativni značaj TP , kao i korelacija TP i terapijskog odgovora histološke regresije kod R0 reseciranih sinhronih i metahronih jetrenih metast
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5

Novosadová, Michaela. "Segmentace 3D obrazových dat s využitím pokročilých texturních a tvarových příznaků." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-221144.

Testo completo
Abstract (sommario):
This thesis first describes theory of range of methods of textural and shape analysis. In several published articles some of the mentioned methods are used for automatic detection of lesion in spine in CT images. Some of these articles are shortly presented (in this thesis). Next part of the thesis includes description of various classifiers which are used for classification of feature vectors. Practical part of the thesis is a design and implementation of image data segmentation solution (metastatic lesions in vertebrae) with use of classification of feature vectors formed by texture and shap
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6

Stahler, Arndt [Verfasser], and Volker [Akademischer Betreuer] Heinemann. "Einfluss der mRNA-Expression der EGFR-Liganden Epiregulin (EREG) und Amphiregulin (AREG) auf das Überleben von Patienten mit metasta-siertem kolorektalen Karzinom unter 5-Fluoruracil/Leucovorin plus Irino-tecan (FUFIRI) oder Irinotecan plus Oxaliplatin Erstlinientherapie (FIRE 1 – Studie) / Arndt Stahler ; Betreuer: Volker Heinemann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1156172977/34.

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7

Marijana, Basta Nikolić. "Magnetnorezonantna sekvenca difuzionog kretanja u proceni metastatske invazije limfnih čvorova kod malignih tumora ženskih polnih organa." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101131&source=NDLTD&language=en.

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Abstract (sommario):
UVOD: Maligni tumori reproduktivnih organa nalaze se među vodećim uzrocima obolevanja i umiranja od malignih bolesti žena, kako u svetu, tako i u Srbiji. Jedan od najvažnijih puteva širenja ovih bolesti je limfogeni, a konvencionalna radiološka dijagnostika limfnih čvorova kod ovih pacijentkinja je neprecizna. Funkcionalna radiološka dijagnostika, uključujući i magnentno rezonantnu sekvencu difuzionog kretanja (DWI) i iz nje izvedenu ADC mapu koja omogućava kvantitativnu analizu difuzionih osobina unutar limfnog čvora, daju obećavajuće rezultate u mogućnosti razlikovanja b
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8

Malínský, Miloš. "Pokročilé algoritmy fúze 3D medicínských dat pro specifické lékařské problémy." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-233603.

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Abstract (sommario):
Fúze obrazu je dnes jednou z nejběžnějších avšak stále velmi diskutovanou oblastí v lékařském zobrazování a hraje důležitou roli ve všech oblastech lékařské péče jako je diagnóza, léčba a chirurgie. V této dizertační práci jsou představeny tři projekty, které jsou velmi úzce spojeny s oblastí fúze medicínských dat. První projekt pojednává o 3D CT subtrakční angiografii dolních končetin. V práci je využito kombinace kontrastních a nekontrastních dat pro získání kompletního cévního stromu. Druhý projekt se zabývá fúzí DTI a T1 váhovaných MRI dat mozku. Cílem tohoto projektu je zkombinovat stuktu
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9

Ivana, Kolarov Bjelobrk. "Klinička vrednost određivanja prisustva tumor infiltrišućih limfocita u bolesnica sa karcinomom dojke." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=96484&source=NDLTD&language=en.

Testo completo
Abstract (sommario):
UVOD: Glavni problem u lečenju karcinoma dojke je kako na osnovu kliničke klasifikacije i morfoloških osobina tumora predvideti njegovo dalje ponašanje. Vrlo često ni kombinacija standardnih prognostičkih faktora ne daje odgovor o potrebi davanja adjuvantne hemioterapije. U cilju sprovođenja adekvatne dalje terapije karcinoma dojke i otkrivanja agresivnih tipova tumora, a nakon hirurškog lečenja, postoji stalna potreba za pronalaženjem novih pokazatelja pomoću kojih bi se identifikovale bolesnice koje imaju povećan rizik od razvoja relapsa bolesti. CILJEVI: Ciljevi su bili
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10

Ilija, Baroš. "Молекуларна и генска хетерогеност метастаза у аксиларним лимфним чворовима код пацијенткиња са инвазивним карциномом дојке". Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110238&source=NDLTD&language=en.

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Abstract (sommario):
HER2 Gene-Protein Assay (GPA) је посебно погодан за истовремено процењивање експресије HER2 протеина и статуса амплификације HER2 гена на нивоу појединачних ћелија и њихово повезивање са ћелијском морфологијом. Циљ истраживања био је испитати да ли су постојећи критеријуми препоручени од стране ASCO/CAP довољни за дијагностиковање HER2 позитивности код пацијенткиња које показују интратуморску хетерогеност, како у примарним туморима тако и у метастазама у регионалне лимфне чворове, учесталост HER2 хетерогености у макрометастазама лоцираним у лимфним чворовима, те да ли постоји јасна корелација
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11

Tupý, Radek. "Komplexní předoperační zobrazování nádorů mozku." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-389253.

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Abstract (sommario):
Title Complex preoperative brain tumor imaging Abstract The differentiation of glioblastoma, metastases and brain lymphoma using modern diagnostic imaging methods has a major impact on the strategy of further diagnostic examinations and treatment. In a group of 67 patients with glioblastoma and 31 with cerebral metastasis, the ability to differentiate them according to the evaluation of perfusion parameters changes in peritumoral white matter by T1 dynamic post-contrast magnetic resonance imaging was verified, with the positive predictive value in glioblastoma detection up to 91%. In a group o
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12

Kosla, Jan. "Molekulární mechanizmy fenotypových přechodů fibroblastických buněk: dediferenciace myofibroblastů a ovlivnění invazivity a metastazování sarkomu." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-327416.

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Abstract (sommario):
Fibroblasts are the principal cellular component of the connective tissue. They are a heterogeneous group of cells which contribute to the structure of connective tissue and wound healing by their ability to produce extracellular matrix (ECM). Fibroblasts and cells derived from them are involved in many pathological processes such as formation of malignant tumors and fibrosis. Tumor progression which finally leads to metastasis is a serious biomedical problem. There is a growing body of the recent evidence showing an important role of the tumor stroma and its interaction with cancer cells in c
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13

Vágnerová, Lenka. "Využití testu CAM pro charakterizaci a studium invazivních vlastností rakovinných buněk." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312678.

Testo completo
Abstract (sommario):
The chorioallantoic membrane (CAM) of chicken embryos belongs to the in vivo model systems frequently used for the study of angiogenesis and cell invasiveness. Using CAM assay we have tested selected chicken sarcoma cell lines characterized by different angiogenic properties and different ability to form metastasis. In addition to CAM assay, several other methods have been used to characterize the phenotype of these cell lines. We have selected a few proteins which could significantly influence the angiogenic and metastatic properties of investigated cell lines. We have established cell lines
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14

Reguli, Štefan. "Časná volumetrie mozkových metastáz ošetřených CyberKnife." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-383309.

Testo completo
Abstract (sommario):
The CyberKnife is a device for frameless whole-body radiosurgery using image guided robotic technology and linear accelerator as a photon source. It was introduced in USA in 2001. First CyberKnife device in eastern ad middle Europe was installed in Faculty hospital Ostrava in 2010. So we were given a chance do use the most recent technology in treating oncological patients. Brain metastases are an important and frequently treated indication in modern radiosurgery. This non-invasive method offers good local control with minimum toxicity and repeability of the treatment. Biological aspect and do
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15

Moreira, Marisa Morgado. "Perfil imunohistoquímico do cancro da mama que metastiza com aumento do marcador tumoral." Master's thesis, 2010. http://hdl.handle.net/10316/79531.

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Abstract (sommario):
Tese de mestrado integrado em Medicina, apresentado á Faculdade de Medicina da Universidade de Coimbra<br>Introdução: O cancro da mama é, a nível mundial, o cancro mais comum na mulher e a segunda principal causa de morte por cancro, apresentando incidência crescente. Os marcadores tumorais, por apresentarem baixa sensibilidade e especificidade, têm aplicação clínica limitada. Raramente usados para rastreio ou diagnóstico precoce, a sua principal aplicabilidade é avaliar a resposta após a terapêutica, através de medições seriadas. No entanto, o doseamento de CA 15.3, marcador de eleição no can
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16

Krbal, Lukáš. "Studium metastatických procesů a odpovědi na léčebnou terapii u primokultur izolovaných z kolorektálního karcinomu a metastáz do lymfatických uzlin." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-404790.

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Abstract (sommario):
Study of metastatic processes and response to chemotherapy in primary cultures obtained from colorectal carcinoma and lymph node metastases Colorectal carcinoma is one of the most common malignant diseases in the Czech Republic. Despite an implementation of primary population screening to detect premalignant lesions, the incidence and the mortality of the disease do not appear to decrease significantly. A significant percentage of patients still manifest with late (metastatic) stage of the disease. Isolation of primary cell cultures of colorectal carcinoma is a method in which a large number o
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17

ČECHOVÁ, Magda. "Studium možnosti ovlivnění metastázování pomocí proenzymoterapie." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-79750.

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Abstract (sommario):
The aim of this thesis was to study the possibilities of influencing the metastasizing processes by means of proenzyme therapy. We accented the role of primary tumor excision. In the second part of the thesis we carried out our first screening experiments in the new area of cancer treatment based on tumour coupled PAMPs.
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18

Fichtl, Jakub. "Regenerace jaterního parenchymu pomocí aplikace hematopoetických progenitorových buněk po embolizaci portálního řečiště u nemocných s primárně inoperabilními metastázami kolorektálního karcinomu do jater." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-351291.

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Abstract (sommario):
Introduction: The reason for the inability of performing the liver resection for colorectal carcinoma metastasis is usually insufficient remnant liver parenchyma after liver resection (future liver remnant volume - FLRV). The current standard method of increasing FLRV is the embolization of the branch of portal vein (portal vein embolization - PVE) on the side of the tumor, and then suspended after hypertrophy of the non-embolised lobe liver resection. Unfortunately, there are some patients who do not increase liver volume despite perfectly executed PVE. Besides that, FLRV occurs during the ti
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19

Šůchová, Anna-Marie. "Vliv signalizace související se zánětem na invazivitu nádorových buněk." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436102.

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Abstract (sommario):
Metastasizing is responsible for 90% of death in cancer patients. Metastatic tumour cells have several strategies that they use to invade surrounding tissues - they can migrate together or individually. When individual cells migrate, tumour cells adopt two different morphologies. They are either elongated and migrate using the proteolytically active mesenchymal mode, or they are rounded and migrate in the amoeboid mode. Metastatic tumour cells can switch between these modes, which complicates the development of effective migrastatics. In this work, we focused on the effect of inflammatory sign
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20

Čermák, Vladimír. "Regulace transkripce proteiny rodin Early growth response a Myb." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328727.

Testo completo
Abstract (sommario):
The regulation of transcription of tens of thousands of genes in a vertebrate organism is an enormously complex phenomenon which entails the participation of thousands of various regulatory proteins. The largest functional category of these regulators is accounted for by sequence-specific DNA-binding proteins known as transcription factors. Proteins of the EGR and Myb families of transcription factors are long-studied regulators of a variety of physiological processes including cellular proliferation and differentiation. The structural and physical aspects of their function have been well char
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21

Lyková, Dominika. "Lokalizace a transport proteáz mezibuněčné hmoty." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355673.

Testo completo
Abstract (sommario):
Metastasis is the main cause of death from solid cancer. The dissemination of cancer cells from a primary tumour is a very complex process that involves many steps and cells must overcome many obstacles to colonize distant organs. The tumour microenvironment influences the mode and the dynamics of invasion of cancer cells. Cancer cells have the ability to adapt to distinct environmental conditions in order to stay motile. Invasive cancer cells form membrane protrusions called invadopodia that are able to degrade extracellular matrix. The formation of invadopodia by cancer cells is interconnect
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22

Brůha, Jan. "Význam tumor infiltrujících lymfocytů jako prognostických faktorů u pacientů po embolizaci portální žíly (PVE) a po PVE s aplikací autologních kmenových buněk." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-450509.

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Abstract (sommario):
Relevance of tumor infiltrating lymphocytes as a prognostic factors in patients with portal vein embolisation (PVE) and patients with PVE and administration of autologous stem cells Background: low future liver remnant volume (FLRV) is the cause of why 75% of patients with colorectal liver metastases (CLM) are primarily inoperable. Portal vein embolisation (PVE) helps to increase FLRV and so increase the operability. But PVE fails in almost 40 % of patients. Usage of stem cells (SCs) could be the way how to support the effect of PVE. Currently, there are studies of interactions of the immune s
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23

Belšánová, Barbora. "Optimalizace metodiky pro stanovení volné nádorové DNA v plazmě a její klinické využití u pacientů s karcinomy kolorekta, plic a slinivky břišní." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368058.

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Abstract (sommario):
In current days, examination of circulating tumor DNA (ctDNA) finds new use across different cancers. It is directed at tumor-derived short fragments of DNA present in peripheral blood of patiens (mainly in advanced stages). Due to its minimal invasivity, almost 100 % specificity and relatively high sensitivity in stage IV patients, this approch found its main potential clinical utility especially in early detection of disease relapse or progression after tumor resection (i.e. post-operative follow-up), prediction and monitoring of therapy response and estimation of prognosis. As a result of m
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