Готові списки джерел за темами / Endocrine aspects of Immunity

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Добірка наукової літератури з теми "Endocrine aspects of Immunity"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 7 лютого 2022

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Статті в журналах з теми "Endocrine aspects of Immunity"

1

Adriana, Gherbon. "Aspects of Humoral Immunity in a Group of Children With Type 1 Diabetes and Thyroid Disorders." European Scientific Journal, ESJ 12, no. 36 (December 31, 2016): 18. http://dx.doi.org/10.19044/esj.2016.v12n36p18.

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Patients with diabetes have a high prevalence of thyroid disease compared with non-diabetic population. In the case of type 1 diabetes, it is often associated with autoimmune endocrine and systemic diseases as: Graves-Basedow disease, autoimmune chonic thyroiditis (ACT), Addison's disease, celiac disease, pernicious anemia, myasthenia gravis, vitiligo, etc.. The purpose of this study is to determine the main aspects of humoral immunity in a group of children with type 1 diabetes and thyroid disorders. The studied group was represented by 83 cases (71 girls and 12 boys), aged between 7-17 years. They were used clinical, imaging, biochemical, hormonal and immunological parameters. Results: Prevalence of positive anthyroid antibodies (ACAT) in the study group was: Basedow – Graves disease – 100% (both), ACT - 85.18% antiTPO and 83.33% antiTg, euthyroid difusse goiter – 0% (both). In the case of children and adolescents with type 1 diabetes and ACT with positive antiTPO AB we notice that they had a younger onset age of diabetes (4.86 ± 3.94 vs. 8.62 ± 0.51 years), a longer duration of diabetes (9.23 ± 4.05 vs. 8.12 ± 0.64 years), elevated HbA1c values (8.91 ± 2.03 vs.7, 55 ± 1.96%) and lower TSH values (12.00 ± 23.7 vs. 14.77 ± 17.03 mIU/ml) than those negative. Conclusions: It is recommended determination of antithyroid antibodies, particularly those antiTPO in children and adolescents with type 1 diabetes at onset of diabetes, or before puberty and, if they are positive should be tested the thyroid function annually to minimize the risk of undiagnosed hypothyroidism.
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2

Zhelavskyi, M. M. "Immunobiological aspects of cow lactation." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 95 (November 2, 2019): 3–8. http://dx.doi.org/10.32718/nvlvet9501.

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Lactation of cows is a high-energy metabolic process. It is regulated in the body by the complex physiological mechanisms of the nervous, endocrine and immune systems. The purpose of to study changes in the immunobiological reactivity of the body of cows during lactation. Clinical and experimental studies were accomplished at the veterinary clinic and in the specialized laboratory of reproductive animal immunology. For the study, four groups of analogues of experimental animals were formed in which the immunological methods determined the immune status: cows (n = 17) during the early lactation (secretion of colostrum, 3–5th day); second (n = 32) – cows (n = 32) in the mid (3–5th month) lactation; the third (n = 28) – during the late lactation (5–7th day) and the fourth group (n = 28) – during the dry period (12–20th day). Our research has shown that during lactation in the body of cows fluctuations of the studied indicators of cellular and humoral immunity occur. Experimental data that showed that the percentage of T-lymphocytes in the blood of cows of Ukrainian dairy black-billed breed during the initial (3–5 days) period of lactogenesis is the lowest (37.88 ± 1.53%). However, the lowest expression of B-immune cells (16.05 ± 0.74%) was also detected during colostrum secretion. These changes occurred against the background of the decrease in CD3+/СD22+ (2.36 ± 0.11). In particular, at the 3–5th month of lactation, peripheral blood flow contained 53.40 ± 0.83% CD3+, ie 1.40 times more. The number of CD22+ mononuclear cells increased by only 1.14 times (up to 18.31 ± 0.69%). The beginning late lactation and dry period in the number of immunocompetent cells was observed: CD3+ – up to 42.11 ± 1.03%, and CD22+ – up to 22.92 ± 0.89%. All this was accompanied by a corresponding redistribution of the balance (CD3+/СD22+). We have identified certain patterns in the blast transformation ability of T-lymphocytes, which was manifested in the change in the activity of activated immune cells of blood. At the beginning of lactation, the functional capacity of T cells was the lowest (42.47 ± 0.62%). But subsequently with the increase of the lactation curve there was a certain activation of their transformation into blasts (51.11 ± 1.05%). At the beginning of late lactation cows underwent a gradual decrease in the blasttransformation capacity of immunocompetent cells (43.11 ± 0.89%). And which continued to decline gradually during the dry period. Thus, during lactation in the body of cows there are dynamic permanent changes in the system of cellular and humoral immunity. From the beginning of lactogenesis, there is a gradual increase in the increase in the functioning of the mammary gland of cows, and further decrease in the population composition of CD3+ and СD22+, which was also accompanied by changes in the functional activity of immunocompetent cells.
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3

Tang, Tian, Jinghan Yang, and Siyuan Jing. "A Preliminary Study on the Mechanism of Premature Ovarian Failure." Proceedings of Anticancer Research 5, no. 4 (July 29, 2021): 34–39. http://dx.doi.org/10.26689/par.v5i4.2318.

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Premature ovarian failure (POF) refers to the failure of ovaries which causes amenorrhea before the age of 40. It is characterized by primary or secondary amenorrhea along with elevated blood gonadotropin levels and decreased estrogen levels with varying degrees of low estrogen symptoms such as hot flashes and sweating, facial flushing, reduced libido, and so on. Premature ovarian failure (POF) is a common endocrine disease in gynecology. The incidence of POF is increasing year by year and the affected population increasingly involves the younger-aged groups. Its etiology is complex and diverse involving many factors such as genetics, immunity, medical treatment, environment endocrine disruptors, etc. It is also affected by long-term smoking, alcohol intake, and other behaviors which damage patients’ physical and mental health. In recent years, the effects of gene therapy in restoring ovarian function and improving fertility in animal experiments have provided a new direction for POF patients. This article discusses the etiology and possible pathogenesis of POF and BRCA from various aspects as well as summarizes the recent research status and progress of new treatment methods of POF.
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4

Meier, Ursula, and Axel M. Gressner. "Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin." Clinical Chemistry 50, no. 9 (September 1, 2004): 1511–25. http://dx.doi.org/10.1373/clinchem.2004.032482.

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Abstract Background: Recent studies point to the adipose tissue as a highly active endocrine organ secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to take part in the regulation of energy metabolism. Approach: This review summarizes recent knowledge on leptin and its receptor and on ghrelin, adiponectin, and resistin, and emphasizes their roles in pathobiochemistry and clinical chemistry. Content: Leptin, adiponectin, and resistin are produced by the adipose tissue. The protein leptin, a satiety hormone, regulates appetite and energy balance of the body. Adiponectin could suppress the development of atherosclerosis and liver fibrosis and might play a role as an antiinflammatory hormone. Increased resistin concentrations might cause insulin resistance and thus could link obesity with type II diabetes. Ghrelin is produced in the stomach. In addition to its role in long-term regulation of energy metabolism, it is involved in the short-term regulation of feeding. These hormones have important roles in energy homeostasis, glucose and lipid metabolism, reproduction, cardiovascular function, and immunity. They directly influence other organ systems, including the brain, liver, and skeletal muscle, and are significantly regulated by nutritional status. This newly discovered secretory function has extended the biological relevance of adipose tissue, which is no longer considered as only an energy storage site. Summary: The functional roles, structures, synthesis, analytical aspects, and clinical significance of leptin, ghrelin, adiponectin, and resistin are summarized.
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5

Torino, Francesco, Agnese Barnabei, Rosa Maria Paragliola, Paolo Marchetti, Roberto Salvatori, and Salvatore Maria Corsello. "ENDOCRINE SIDE-EFFECTS OF ANTI-CANCER DRUGS: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses." European Journal of Endocrinology 169, no. 6 (December 2013): R153—R164. http://dx.doi.org/10.1530/eje-13-0434.

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mAbs are established targeted therapies for several diseases, including hematological and solid malignancies. These agents have shown a favorable toxicity profile, but, despite their high selectivity, new typical side-effects have emerged. In cancer patients, pituitary dysfunction may be mainly due to brain metastases or primary tumors and to related surgery and radiotherapy. Anticancer agents may induce hypopituitarism in patients cured for childhood cancers. These agents infrequently affect pituitary function in adult cancer patients. Notably, hypophysitis, a previously very rare disease, has emerged as a distinctive side-effect of ipilimumab and tremelimumab, two mAbs inhibiting the cytotoxic T-lymphocyte antigen-4 receptor, being occasionally seen with nivolumab, another immune checkpoint inhibitor. Enhanced antitumor immunity is the suggested mechanism of action of these drugs and autoimmunity the presumptive mechanism of their toxicity. Recently, ipilimumab has been licensed for the treatment of patients affected by metastatic melanoma. With the expanding use of these drugs, hypophysitis will be progressively encountered by oncologists and endocrinologists in clinical practice. The optimal management of this potentially life-threatening adverse event needs a rapid and timely diagnostic and therapeutic intervention. Hypopituitarism caused by these agents is rarely reversible, requiring prolonged or lifelong substitutive hormonal treatment. Further studies are needed to clarify several clinical and pathogenic aspects of this new form of secondary pituitary dysfunction.
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6

Zhao, Hongyan, Ning Zhao, Peng Zheng, Xiaohong Xu, Meijie Liu, Dan Luo, Huihui Xu, and Dahong Ju. "Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation." Journal of Immunology Research 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/6345857.

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Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis. Immune and bone cells are located in the bone marrow and share numerous regulatory molecules, signaling molecules, and transcription factors. Abnormal activation of the immune system alters the balance between osteoblasts and osteoclasts, which results in an imbalance of bone remodeling and osteoporosis. The incidence of osteoporosis is also increasing with the aging of China’s population, and traditional Chinese medicine has played a vital role in the prevention and treatment of osteoporosis for centuries. Chinese medicinal plants possess unique advantages in the regulation of the immune system and the relationships between osteoporosis and the immune system. In this review, we provide a general overview of Chinese medicinal plants in the prevention and treatment of osteoporosis, focusing on immunological aspects.
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7

Srinivasan, N., V. Swarnapriya, A. J. W. Felix, and T. Pravin. "Assessment of knowledge and practice on plastics among the professional course students of Annamalai University, Tamil Nadu." International Journal Of Community Medicine And Public Health 6, no. 2 (January 24, 2019): 510. http://dx.doi.org/10.18203/2394-6040.ijcmph20190099.

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Background: The use of plastics made life easy in day to day life. However, the disposal of it remains a public health problem worldwide. Plastic waste are major cause of environment pollution becomes carcinogenic to human, birth defects, impaired immunity, endocrine disruption, development and reproductive effect. Raising the awareness of the different stake holders is suggested by United Nations Environment Programme. Assessing the knowledge and practice of the student community, especially of the professional courses, in this regard is considered as a vital one.Methods: A total of 563 students of professional courses were included in the study. Their knowledge in terms general aspects, ill effects, reuse and practice in terms of usage and disposal were assessed with a questionnaire.Results: 46% of the students found having good knowledge. Only 27.6% were found to have good practice. Though the students have good knowledge on ill effects of plastics, their practice in terms of disposal was less. Significant variations were observed among the students of different courses.Conclusions: Addressing the gap between knowledge and practice in terms of designing messages for proper disposal and avoiding usage of single use plastics at individual and collective level is required.
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8

Tilg, Herbert, and Alexander R. Moschen. "Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases." Clinical Science 114, no. 4 (January 15, 2008): 275–88. http://dx.doi.org/10.1042/cs20070196.

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Obesity and obesity-related disorders play an important role in clinical medicine. Adipose tissue, with its soluble mediators called adipocytokines, has emerged as a major endocrine organ. These adipocytokines comprise many mediators such as adiponectin, PBEF (pre-B-cell-enhancing factor)/visfatin, leptin, resistin, retinol-binding protein-4 and others. They play major roles in key aspects of metabolism, such as insulin resistance, fatty acid oxidation, inflammation and immunity. Adiponectin, a prototypic adipocytokine, is of importance in the regulation of insulin resistance, as circulating levels are decreased in obesity and diseases associated with insulin resistance. Besides its major role in regulation of insulin sensitivity, recent evidence suggests potent anti-inflammatory functions for adiponectin. These effects are paralleled by other immune-regulatory properties, such as regulation of endothelial cell function. The in vitro effects of adiponectin have been corroborated by several studies demonstrating potent in vivo anti-inflammatory effects. Many other adipocytokines, such as PBEF/visfatin, leptin, resistin or retinol binding protein-4, are involved in the physiology and pathophysiology of adipocytes, adipose tissue and related diseases. PBEF/visfatin, another recently characterized adipocytokine, has been linked to several inflammatory disease states beyond insulin resistance, such as acute lung injury or inflammatory bowel diseases. It has been recognized for many decades that obesity is accompanied by an increase in cancer and potentially some immune-mediated diseases. Understanding this new exciting world of adipocytokines will be of importance in the development of novel therapies for obesity-associated diseases.
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9

Falzoni, Simonetta, Giovanna Donvito, and Francesco Di Virgilio. "Detecting adenosine triphosphate in the pericellular space." Interface Focus 3, no. 3 (June 6, 2013): 20120101. http://dx.doi.org/10.1098/rsfs.2012.0101.

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Release of adenosine triphosphate (ATP) into the extracellular space occurs in response to a multiplicity of physiological and pathological stimuli in virtually all cells and tissues. A role for extracellular ATP has been identified in processes as different as neurotransmission, endocrine and exocrine secretion, smooth muscle contraction, bone metabolism, cell proliferation, immunity and inflammation. However, ATP measurement in the extracellular space has proved a daunting task until recently. To tackle this challenge, some years ago, we designed and engineered a novel luciferase probe targeted to and expressed on the outer aspect of the plasma membrane. This novel probe was constructed by appending to firefly luciferase the N-terminal leader sequence and the C-terminal glycophosphatidylinositol anchor of the folate receptor. This chimeric protein, named plasma membrane luciferase, is targeted and localized to the outer side of the plasma membrane. With this probe, we have generated stably transfected HEK293 cell clones that act as an in vitro and in vivo sensor of the extracellular ATP concentration in several disease conditions, such as experimentally induced tumours and inflammation.
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10

Greco, Deborah S., and Lynn M. Harpold. "Immunity and the Endocrine System." Veterinary Clinics of North America: Small Animal Practice 24, no. 4 (July 1994): 765–82. http://dx.doi.org/10.1016/s0195-5616(94)50083-4.

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Більше джерел

Дисертації з теми "Endocrine aspects of Immunity"

1

Ritchie, Catherine Marian. "Aspects of hypertension in endocrine disease." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357488.

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2

Delgado, Verdugo Alberto. "Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224111.

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Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. This opens the question if there exists a single or several endocrine tumor genes. The aim of the study was to describe genetic derangements in endocrine tumors. Paper I: Investigation of mutational status of SDHAF2 in parathyroid tumors. SDHAF2 is located in the proximity of 11q13, a region that frequently displays loss in parathyroid tumors. We established that mutations in SDHAF2 are infrequent in parathyroid tumors. Paper II: Study of SDHAF2 gene expression in a cohort of benign pheochromocytomas (PCC) (n=40) and malignant PCC (n=10). We discovered a subset of  benign PCC (28/40) and all malignant PCC (10/10) with significantly lower SDHAF2 expression. Benign PCC with low SDHAF2 expression and malignant tumors consistently expressing low levels of SDHAF2 were methylated in the promoter region. SDHAF2 expression was restored in vitro after treatment with 5- aza-2-deoxycytidine. Paper III: HumanMethylation27 array (Illumina) covering 27578 CpG sites spanning over 14495 genes were analyzed in a discovery cohort of 10 primary small neuroendocrine tumors (SI-NETs) with matched metastases. 2697 genes showed different methylation pattern between the primary tumor and its metastasis. We identified several hypermethylated genes in key regions. Unsupervised clustering of the tumors identified three distinct clusters, one with a highly malignant behavior. Paper IV: Loss of chromosome 18 is the most frequent genetic aberration in SI-NETs. DNA from SI-NETs were subjected to whole exome capture sequencing and high resolution SNP array. Genomic profiling revealed loss of chromosome 18 in 5 out of 7 SI-NETs. No tumor-specific somatic mutation on chromosome 18 was identified which suggests involvement of other mechanisms than point mutations in SI-NET tumorigenesis. Paper V: The cost for diagnostic genetic screening of common susceptibility genes in PCC is expensive and labor intensive. Three PCC from three patients with no known family history were chosen for exome capture sequencing. We identified three variants in known candidate genes. We suggest that exome-capture sequencing is a quick and cost-effective tool.
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3

Bauer, Moises Evandro. "Endocrine-immune interactions in major depression, acute and chronic stress." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266950.

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4

Merani, Salima A. "Development of a specific and sensitive assay for cholecystokinin, and applications thereof." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37619.

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Cholecystokinin, or "CCK" peptides, originally identified in the gastrointestinal tract, are now considered to be one of the most abundant peptide systems in the mammalian central nervous system. Prompted by recent findings that implicated the cholecystokinergic system in the pathophysiology of various illnesses, we developed a novel assay system to measure the various forms of cholecystokinin peptides in human plasma and cerebrospinal fluid. The system detects CCK-4, sulfated CCK-8 (CCK-8s) and nonsulfated CCK-8 (CCK-8ns) with equal affinity, with the lower detection limit of 2.7 fmol and an ED50 of 10.6 +/- 2.2 fmol. Using the assay system, we determined that mean CCK-like immunoreactivity (CCK-LI) in the plasma of 12 healthy subjects was 12.9 +/- 2.1 pM CCK-4 equivalents.
After developing the cholecystokinin assay system, we were able to combine our unique methodology with other established techniques to investigate the role of CCK in illnesses such as premenstrual dysphoric disorder (PMDD), anxiety, bulimia nervosa, and cardiomyopathy.
Briefly, we observed no significant differences in plasma CCK levels between women with PMDD and healthy volunteers. However, we found that, independent of diagnosis, plasma cholecystokinin concentrations were higher in women during their first visit to the clinic to participate in the study, as compared to later visits.
In addition, application of our assay system allowed us to determine that oral ingestion of caffeine increased plasma CCK-LI levels 2--4 fold in humans. Moreover, we observed substantial variation in post-caffeine cholecystokinin levels among individuals.
In another study of cholecystokinin and anxiety, we used our CCK assay to determine the effects of ondansetron, a serotonin receptor antagonist, on cholecystokinin levels in plasma. We found that multiple oral doses of ondansetron influence the pharmacokinetic parameters of exogenous CCK.
We also used the three-step assay system to measure CCK-LI in patients with the eating disorder, bulimia nervosa. Baseline fasted cholecystokinin plasma levels were lower in bulimic women as compared to control subjects. However, at "satiety", or the post-binge stage, CCK levels in bulimic women were similar to those of control women.
Finally, our investigation into the role of cholecystokinin in cardiomyopathy revealed that neuronal cholecystokinin receptor density was altered in the cardiomyopathic hamster brain, as compared to age- and sex-matched control animals. (Abstract shortened by UMI.)
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5

Henderson, Keith Meade. "Aspects of the endocrine control of ovarian function." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/14052.

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This thesis consists of papers, published by the candidate between 1975 and 1991, describing the results of investigations into the endocrine control of ovarian function. The papers are presented in chronological order in each of five sections. Each section deals with a different apsect of the research undertaken by the candidate during the sixteen year period. Section 2 is concerned with investigations of follicle development and follicle steroidogenesis. Papers concerned with inhibin are presented in section 3. The papers in section 4 describe studies to investigate the mechanism(s) responsible for the high ovulation rates observed in Booroola ewes carrying a fecundity (F) gene. Section 5 contains papers related to the manipulation of ovulation rate.
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6

Heaney, Anthony Patrick. "Aspects of pituitary and adrenal disease." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295358.

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7

Yan, Ke-Ting. "Aspects of immunity to Leptospira borgpetersenii serovar hardjo." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387931.

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8

Behera, Malabika. "Long term endocrine sequelae of childhood cancer survivors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206611.

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Background: Newer multimodality therapeutic interventions have resulted in dramatic survival rates in childhood cancers. However diverse treatment related morbidities affect the long term survivors. An Endocrine complication comprises 20-40% of these morbidities and affects the hypothalamic pituitary axis, growth, pubertal progression, fertility, bone health and glucose homeostasis. Objectives: The aim of our study was to enumerate and evaluate the frequency of endocrine complications arising as a late effect of treatment in childhood cancer survivors. Risk factors likely to be associated with these complications were also evaluated. Methodology: Retrospective analysis of medical records from the Long Term Endocrine Follow up clinic in the Department of Paediatrics and Adolescent Medicine of Queen Mary Hospital was done. Patients with a primary diagnosis of Cancer and Langerhans cell histiocytosis with endocrine sequelae arising from various treatment modalities who have survived 5 years after diagnosis were included in the study. Those who had endocrine complications arising from various treatment modalities for Thalassemia’s, Immunodeficiency’s were excluded from the study Results: 135 cases were included in the study and 27 were excluded. Leukemia and Brain tumor survivors were the majority accounting for 40% and 26.67% respectively. ALL formed majority of leukemia survivors, Medulloblastoma survivors accounted for 50% of brain tumor survivors. Most common endocrine problem was Hypogonadism in 51.1% of cases, followed by growth disturbances in 40%, Thyroid dysfunction in 23% and Hyperlipidemias in 18.5%. Pubertal problems, Central Diabetes Insipidus, Adrenal insufficiency, Obesity, Altered glucose homeostasis were rest of the problems in small frequencies. PHGN (Primary Hypogonadism) was present in 91.3% and mostly in prepubertal males. PHGN was statistically associated with Leukemia survivors with OR-2.06 (1.02- 4.15), p value 0.04. The risk factors associated were exposure to alkylating agents, radiotherapy, TBI prior to transplant. SHGN (Secondary HGN) was statistically associated with Brain tumor survivor OR - 15.8 (1.7-140.5), p value 0.013. Cranial irradiation was the major risk for SHGN. PGV (Poor growth velocity) was the major growth problem.GHD (Growth Hormone Deficiency) had a highly significant association with Brain tumors (p value ˂ 0.0001), and significantly associated when all 3 modalities of treatment given together (p value 0.01). Risk factors for GHD were cranial radiotherapy, exposure to cyclophosphamide and TBI. PH (Primary Hypothyroidism) had highly significant association with craniospinal radiotherapy (p value ˂ 0.0001), and significantly associated with brain tumors. Similar results were observed in patients of CH (Central Hypothyroidism). Hyperlipidemias were present in 18% with no statistical correlation with the type of cancer. Brain tumor survivors had a significant association of GHD, PH, CH, SHGN and CDI. Leukemia survivors had significant association with GHD and PHGN. Conclusions: Endocrine problems are frequent manifestations of late effects of cancer related treatments. Early detection and intervention of these potentially treatable problems could be done through structured long term surveillance. Increasing awareness among health care professionals to anticipate problems in suspected patients and education of patients would optimize health care and quality of life.
published_or_final_version
Paediatrics and Adolescent Medicine
Master
Master of Medical Sciences
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9

Fjällskog, Marie-Louise. "Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2709.

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We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs.

Thirty-six patients with neuroendocrine tumors were treated with cisplatin combined with etoposide. Of 14 patients with evaluable EPTs, 50% responded radiologically and/or biochemically (median duration 9 months). We consider this treatment useful as first-line medical treatment in aggressive EPTs or in patients failing prior chemotherapy.

Twenty-eight tumor tissues from EPTs were examined with immunohistochemistry regarding expression of somatostatin receptors (ssts) 1 to 5 on tumor cells and in intratumoral vessels. We found that sst2 and sst4 were highly expressed on tumor cells and in vessels. However, sst3 and sst5 were lacking in half of the tumor tissues and in most of the vessels. Because of the variability in sst expression, we recommend analysis of each individual’s receptor expression before starting treatment.

Endocrine pancreatic tumors (EPTs) are rare with an incidence of 4 per million inhabitants. In the majority of cases they grow slowly, but there are exceptions with very rapidly progressing malignant carcinomas. First-line medical treatment is streptozotocin combined with 5-fluorouracil.

We examined 38 tumor samples regarding expression of tyrosine kinase receptors platelet-derived growth factor receptors (PDGFRs), c-kit and epidermal growth factor receptor (EGFR). We found that the receptors were expressed in more than half of the tumor tissues. Further studies will reveal if tyrosin kinase antagonists can be part of the future treatment arsenal.

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10

Chu, Xia. "Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands." Doctoral thesis, Uppsala universitet, Endokrin Onkologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254817.

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Multiple endocrine neoplasia syndrome type 1 (MEN1) is an autosomal dominantly inherited disease, which is described as an association of tumors mainly in endocrine organs, including pancreas and adrenal glands. Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in MEN1 patients. More than one third of the MEN1 patients also develop enlargement of the adrenals. MEN1 is caused by a germline mutation of MEN1 gene, a tumor suppressor gene that is located on the human chromosome 11. As noticed, the MEN1 related tumors often develop prior to inactivation of both wild type alleles, indicating MEN1 haploinsufficiency. In this thesis, I utilized a conventional Men1 mouse model that has the phenotype mimicking the human MEN 1 traits, in order to investigate MEN1 tumorigenesis in endocrine pancreas and adrenal glands.   The microvascular aberrations contributing to development and maintenance of PNETs were characterized. The increased vascular density of PNETs developed in the Men1 mice was paralleled by an early and extensive redistribution of pericytes within endocrine tissue. These morphological alterations were supported by fine-tuned variations in expression of several angiogenic regulators  (VEGF, FGF and PDGF) and were further potentiated by hypoxia. Vascular reactivity and blood perfusion of tumor arterioles were significantly altered in response to glucose and L-nitro-arginine methyl ester. Investigation of adrenals from10-month-old Men1 mice showed 681 proteins in mass spectrometry data sets, in which 52 proteins were commonly found in the Men1+/+ and Men1+/- adrenals, and the differential expression between the genotypes reached significant levels. Prdx3, catalyzing the reduction of oxidative stress to cell survival, is one of the overexpressed proteins. Some proteins belonging to the PPARα pathway, e.g. ACLY were also overexpressed. Subsequent microRNA (miRNA) profiling analysis of adrenals from the same age group revealed 31 miRNAs whose expression was significantly altered in comparison between the genotypes. The tumor suppressor miRNAs, miR-486, miR-330 and miR-214, were significantly downregulated in Men1+/- adrenals. The latter, miR-214, is known to inhibit ACLY expression. This finding was in concordance with the proteomic analysis. The oncogene miRNAs, miR-132 and miR-494, were significantly enhanced in the Men1+/- adrenals. Gene ontology analysis demonstrated overrepresentation of the miRNA-targeted genes that are involved in nucleic acid metabolism, vasculature development, angiogenesis, and transcription. Together, these finding after validation in humans may be exploited to improve MEN1 cancer treatment.
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Книги з теми "Endocrine aspects of Immunity"

1

International Conference on Hormones and Immunity (1st 1986 Toronto, Ont.). Hormones and immunity. Lancaster, [Eng.]: MTP Press, 1987.

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2

Istvan, Berczi, Kovács Kálmán, and International Congress of Immunology (6th : 1986 : University of Toronto), eds. Hormones and immunity: Proceedings of the First International Conference on Hormones and Immunity held at the University of Toronto, Canada, July 4, 5, 1986. Lancaster: MTP, 1987.

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3

Zelenskai͡a, T. M. Polovye zhelezy i immunitet. Kiev: Nauk. dumka, 1993.

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4

Evstropov, V. M. Immunno-ėndokrinnai͡a︡ reakt͡s︡ii͡a︡ organizma na lokalʹnoe vozdeĭstvie det͡s︡imetrovykh voln. Frunze: Izd-vo "Ilim", 1987.

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5

Willis, Judith Levine. Getting rid of yeast infections. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration], 1997.

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Immunoendocrinology: Scientific and clinical aspects. New York: Humana Press, 2011.

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7

Craig, Roberts, and SpringerLink (Online service), eds. Sex Hormones and Immunity to Infection. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2010.

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8

1990), Stromboli Conference on Aging and Cancer (2nd. Physiological senescence and its postponement: Theoretical approaches and rational interventions : Second Stromboli Conference on Aging and Cancer. New York, N.Y: New York Academy of Sciences, 1991.

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9

Walter, Pierpaoli, and Fabris N, eds. Physiological senescence and its postponement: Theoretical approaches and rational interventions. New York, N.Y: New York Academy of Sciences, 1991.

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10

Károly, Lapis, Eckhardt S, and International Union against Cancer, eds. Endocrine aspects of malignancies. Budapest: Akadémiai Kiadó, 1987.

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Частини книг з теми "Endocrine aspects of Immunity"

1

Vujović, Svetlana, M. Ivović, M. Tančić Gajić, L. J. Marina, Z. Arizanović, M. Barać, S. Popovic, et al. "Transsexualism: Endocrine Aspects." In ISGE Series, 47–52. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-09662-9_6.

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2

Vinson, S. Bradleigh. "Interactions between the Insect Endocrine System and the Immune System." In Insect Immunity, 103–12. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1618-3_8.

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3

Potter, C. W., and R. C. Rees. "Viruses, Immunity, and Cancer." In Immunological Aspects of Cancer, 207–40. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2557-4_11.

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Cunliffe, R. N., and Y. R. Mahida. "Intestinal mucosal innate immunity." In Immunological Aspects of Gastroenterology, 1–33. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0790-0_1.

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Nappi, A. J., and M. Sugumaran. "Some Biochemical Aspects of Eumelanin Formation in Insect Immunity." In Insect Immunity, 131–48. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1618-3_10.

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Loewenstein, Richard J., and David R. Rubinow. "Psychiatric Aspects of AIDS." In Viruses, Immunity, and Mental Disorders, 95–107. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1799-9_8.

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Pozzilli, Paolo, Rocky Strollo, and Nicola Napoli. "Drug-Induced Endocrine Autoimmunity." In Immunoendocrinology: Scientific and Clinical Aspects, 157–79. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-478-4_10.

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Macpherson, A. J. S., and K. J. Maloy. "Adaptive immunity in the gastrointestinal tract." In Immunological Aspects of Gastroenterology, 35–53. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0790-0_2.

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Kam, Peter, Ian Power, Michael J. Cousins, and Philip J. Siddal. "General Aspects of Endocrine Physiology." In Principles of Physiology for the Anaesthetist, 361–65. Fourth edition. | Boca Raton : CRC Press, Taylor & Francis Group, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429288210-59.

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Misra, Madhusmita. "Endocrine Aspects of Anorexia Nervosa." In Handbook of Famine, Starvation, and Nutrient Deprivation, 1–19. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-40007-5_115-1.

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Тези доповідей конференцій з теми "Endocrine aspects of Immunity"

1

Song, Qisheng. "Immunity during insect development: Endocrine regulation." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.93556.

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Zavadova, Eva, Bohuslav Konopasek, Michal Vocka, Michaela Miskovicova, Jan Spacek, Terezie Fucikova, and Lubos Petruzelka. "Abstract B9: Abnormalities in cellular and humoral immunity in breast cancer patients resistant to endocrine therapy." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-b9.

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3

Saltykova, E. S., L. R. Gaifullina, A. V. Poskryakov, and A. G. Nikolenko. "INFLUENCE OF IMIDACLOPRIDE ON THE IMMUNITY OF HONEY BEES (APIS MELLIFERA L.)." In V International Scientific Conference CONCEPTUAL AND APPLIED ASPECTS OF INVERTEBRATE SCIENTIFIC RESEARCH AND BIOLOGICAL EDUCATION. Tomsk State University Press, 2020. http://dx.doi.org/10.17223/978-5-94621-931-0-2020-58.

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The effect of the neonicotinoid, which is the most toxic for bees, on the components of the individual immunity of Apis mellifera L. workers, was studied. It was shown that a non-lethal dose of imidacloprid caused pathological changes in the intestine and fat body cells, the insect's reaction to its own decaying cells and tissues, aggregation, adhesion and lysis of granulocytes that removes a significant proportion of protective cells from the bloodstream, the generation of reactive oxygen species under the inhibition of phenol oxidase activity in hemocytes.
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Grachev, Nikolay N., and Sergey N. Safonov. "Schematic and Design Aspects of Interference Immunity in the Design of Analog Devices Electronic Means." In 2018 IEEE International Conference "Quality Management, Transport and Information Security, Information Technologies" (IT&QM&IS). IEEE, 2018. http://dx.doi.org/10.1109/itmqis.2018.8525102.

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5

Bollen, Math H. J., Snezana Cundeva, Jose-Maria Romero Gordon, Sasa Z. Djokic, Kurt Stockman, Jovica V. Milanovic, Robert Neumann, and Gaetan Ethier. "Voltage dip immunity aspects of power-electronics equipment — Recommendations from CIGRE/CIRED/UIE JWG C4.110." In 2010 14th International Power Electronics and Motion Control Conference (EPE/PEMC 2010). IEEE, 2010. http://dx.doi.org/10.1109/epepemc.2010.5606512.

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Bollen, Math H. J., Snezana Cundeva, Jose-Maria Romero Gordon, Sasa Z. Djokic, Kurt Stockman, Jovica V. Milanovic, Robert Neumann, and Gaetan Ethier. "Voltage dip immunity aspects of power-electronics equipment — Recommendations from CIGRE/CIRED/UIE JWG C4.110." In 2011 11th International Conference on Electrical Power Quality and Utilisation - (EPQU). IEEE, 2011. http://dx.doi.org/10.1109/epqu.2011.6128895.

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7

Shayakhmetova, L. A., A. I. Pevneva, and А. V. Chernov. "Socio-psychological aspects of self-regulation of cognitive states in educational activity." In INTERNATIONAL SCIENTIFIC AND PRACTICAL ONLINE CONFERENCE. Знание-М, 2020. http://dx.doi.org/10.38006/907345-50-8.2020.326.337.

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The article considers the problem of the effectiveness of self-regulation of cognitive states, due to various socio-psychological factors. The theoretical and methodological basis of the study is the concept of self-regulation of mental states A. O. Prokhorov. In previous studies, various aspects of the self-regulation of cognitive states were touched, however, the socio-psychological factors of self-regulation of cognitive states remain practically unstudied. The purpose of the study: to identify the role of the psychological climate in determining the effectiveness of self-regulation of cognitive conditions of students in everyday learning activities. In the course of the study, the following methods were used: 1. Test for determining the index of group cohesion K. E. Sisora. 2. Methodology for assessing the microclimate of a student group V. M. Zavyalova. 3. Methodology for the effectiveness of self-regulation of mental states A. O. Prokhorova and A. N. Nazarova. In addition, to determine the effectiveness of self-regulation of mental states, students were asked to identify and evaluate cognitive states that occurred at the beginning, in the middle, and at the end of the lecture. As a result of the study, it was revealed that in groups with an average level of favorable psychological climate prevailed interest and reflection. Students studying in groups with a low-favorable level of psychological climate are more likely to experience states of immunity and boredom. The greatest impact of the psychological climate in the group is affected by such aspects of self-regulation of conditions as physiological processes and behavior: their indicators were higher in groups with a higher level of psychological climate. Further, for a greater differentiation of data using factor analysis, various indicators of the psychological climate were identified: «mutual assistance and support», «security» and «business activity of the group». It has been established that the greatest influence among the identified factors on the effectiveness of self-regulation is exerted by the indicator «group business activity».
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Arnoni, Yoram (Jerry). "A Process Flow Model of ISO 14001 for the Implementation of an Environmental Management System." In ASME 2001 Engineering Technology Conference on Energy. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/etce2001-17094.

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Abstract There is increasing interest all over the world in Environmental Management Systems. Many Japanese electronic companies have mandated that their plants should be registered to ISO 14001 irrespective of what country they are located in. The big three automobile manufacturers in the United States have requested their suppliers to become registered to ISO 14001 within the next few years. The EPA is openly supporting Environmental Management Systems including ISO 14001. Twenty-two US States have enacted legislation that encourages voluntary environmental audits by granting immunity to certain non-compliance issues that was discovered during the audit, providing prior notice of the audit was given to the state and the auditee had no prior knowledge of the non-compliance. In response to the interest in Environmental Management Systems, this paper highlights the process flow from one environmental core element to the next in flow diagrams and gives examples from a number of implemented systems. There are a number of system concepts comprising of core elements that are described in ISO 14001 but the link between the core elements are not always immediately obvious. The main processes are as follows: • Identifying aspects, evaluating which are significant and then implementing control procedures for those issues, monitoring/measuring the outcome of the controls and reporting to management for corrective action or continuous improvement. • Identification of regulatory issues that apply to the organizations activities, keeping up to date with regulatory changes and reporting to regulatory offices as may be required. • Identifying which aspects that the organization wishes to pursue as an improvement program. The improvement program will include objectives, measurable targets for those objectives, the means by which those objectives will be achieved, the time frame and people responsible for the program. • Internal assessments, corrective actions, preventive actions and management review and re-action. An understanding of the EMS core elements and their inter relationship will be of interest to those who are considering implementing an Environmental management System in their organization.
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Khaled, Salma, Peter Haddad, Majid Al-Abdulla, Tarek Bellaj, Yousri Marzouk, Youssef Hasan, Ibrahim Al-Kaabi, et al. "Qatar - Longitudinal Assessment of Mental Health in Pandemics (Q-LAMP)." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0287.

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Aims: Q-LAMP aims to identify risk factors and resilience factors for symptoms of psychiatric illness during the pandemic. Study strengths include the 1-year longitudinal design and the use of standardized instruments already available in English and Arabic. The results will increase understanding of the impact of the pandemic on mental health for better support of the population during the pandemic and in future epidemics. Until an effective vaccine is available or herd immunity is achieved, countries are likely to encounter repeated ‘waves’ of infection. The identification of at-risk groups for mental illness will inform the planning and delivery of individualized treatment including primary prevention. Methodology: Longitudinal online survey; SMS-based recruitment and social media platforms advertisements e.g. Facebook, Instagram; Online consent; Completion time for questionnaires: approx. 20 to 30 minute; Baseline questionnaire with follow up at 3, 6, 9 and 12 months; Study completion date: Sept. 2021. Inclusion criteria: Currently living in Qatar; Qatari residents: citizens and expatriates; Age 18 years; read Arabic or English (questionnaire and consent form available in both languages). Instruments: Sociodemographic questionnaire including personal and family experience of COVID-19 infection; Standard instruments to assess psychiatric morbidity including depression, anxiety and PTSD; research team-designed instruments to assess social impact of pandemic; standard questionnaires to assess resilience, personality, loneliness, religious beliefs and social networks. Results: The analysis was based on 181 observations. Approximately, 3.5% of the sample was from the sms-recruitment method. The sample of completed surveys consisted of 65.0% females and 35.0% males. Qatari respondents comprised 27.0% of the total sample, while 52% of the sample were married, 25% had Grade 12 or lower level of educational attainment, and 46.0% were unemployed. Covid-19 appears to have affected different aspects of people’s lives from personal health to living arrangements, employment, and health of family and friends. Approximately, 41% to 55% of those who responded to the survey perceived changes in their stress levels, mental health, and loneliness to be worse than before the pandemic. Additionally, the wide availability of information about the pandemic on the internet and social media was perceived as source of pandemic-related worries among members of the public. Conclusion: The continued provision of mental health service and educational campaigns about effective stress and mental health management is warranted.
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Mavuru, Lydia. "PRE-SERVICE TEACHERS’ CRITICAL REFLECTION ON THE KNOWLEDGE AND SKILLS LEARNED IN LIFE SCIENCES METHODOLOGY MODULE." In International Conference on Education and New Developments. inScience Press, 2021. http://dx.doi.org/10.36315/2021end101.

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The complex roles teacher educators and teachers face require their ability to critically reflect on their practices. The question is on whether teachers are trained to make critical reflections of learning experiences for them to be able to critically reflect on their teaching practices. Based on constructivist approach, teacher educators continuously reflect on their practices in order to modify and improve their modules. It is however imperative that pre-service teachers who are the recipients, be given an opportunity to critically reflect on the services they receive and at the same time develop critical reflection skills. By creating reflective teaching and learning environments in the Life Sciences Methodology and Practicum module at the beginning of the academic year, 77 Bachelor of Education students specialising in Life Sciences and in their last year of study at a South African University, were purposefully selected to participate in a qualitative study. The study sought to answer the research questions: 1. What are pre-service teachers’ reflections on the knowledge and skills learned in their last year of study? and 2. What pedagogical and content knowledge aspects can be drawn from pre-service teachers’ critical reflection for the improvement of the module Life Sciences Methodology and Practicum? In collecting data, each pre-service teacher was tasked to compile a critical reflection report which they submitted towards the end of the year, and was analysed through content analysis. The findings showed important knowledge and skills learned which included the contextualization of teaching to ensure learners comprehend abstract concepts such as immunity. Amongst the teaching approaches and strategies covered in the module, argumentation as a social constructivist strategy stood out particularly when teaching controversial topics embedded with socioscientific issues e.g. genetics and evolution. The pre-service teachers indicated that the way practical work was taught, equipped them with knowledge and skills on how inquiry-based approaches can be implemented in the classrooms. Suggestions to improve the module included the provision of pre-service teachers with opportunities to conduct virtual micro lessons in light of COVID-19 pandemic; that the testing of Life Sciences concepts should include the assessment of pre-service teachers’ capabilities to teach the same concepts in the classrooms. The pre-service teachers’ argument is that since they are in their final year, the focus of the module should be on the development and assessment of their pedagogical content knowledge (PCK) and TPACK. The findings of the study have implications for teacher professional development.
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