Dissertations / Theses on the topic '毒性'
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松下, 修門. "ヤエヤマサソリ毒液に含まれる殺虫性ペプチド毒素の構造と活性." 京都大学, 2009. http://hdl.handle.net/2433/123984.
Full text0048
新制・課程博士
博士(農学)
甲第14672号
農博第1754号
新制||農||969(附属図書館)
学位論文||H21||N4445(農学部図書室)
UT51-2009-D384
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 宮川 恒, 教授 西田 律夫, 教授 三芳 秀人
学位規則第4条第1項該当
泉尾, 直孝. "アミロイドβ誘発神経毒性における立体構造の役割と毒性発現機構に関する研究." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/175234.
Full textKYOUNGSOO, PARK. "被災下水処理場の暫定処理水に対する塩素やオゾン，紫外線による消毒方法の評価に関する研究." Kyoto University, 2020. http://hdl.handle.net/2433/259033.
Full text長谷川, 雅哉, and 俊隆 鍋島. "フェンフルラミンの中枢神経系への毒性について." 日本トキシコロジー学会, 2002. http://hdl.handle.net/2237/10884.
Full text十一, 浩典. "ヤエヤマサソリ毒液に含まれるβ-KTx毒素ペプチドおよびその部分ペプチドの構造と活性." Kyoto University, 2019. http://hdl.handle.net/2433/242720.
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新制・課程博士
博士(農学)
甲第21843号
農博第2356号
新制||農||1069(附属図書館)
学位論文||H31||N5215(農学部図書室)
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 宮川 恒, 教授 三芳 秀人, 教授 森 直樹
学位規則第4条第1項該当
吉田, 天士. "有毒渦鞭毛藻類における麻痺性貝毒原因毒素に特異的な硫酸基転移酵素に関する研究." 京都大学, 1999. http://hdl.handle.net/2433/157128.
Full textKyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第7589号
農博第1028号
新制||農||773(附属図書館)
学位論文||H11||N3224(農学部図書室)
UT51-99-D206
京都大学大学院農学研究科水産学専攻
(主査)教授 内田 有恆, 教授 坂口 守彦, 教授 中原 紘之
学位規則第4条第1項該当
西本, 高明. "興奮性神経毒性に対するAMPAの保護作用機序に関する研究." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137171.
Full text王耀德 and Yau-Der Wang. "香桂莖部化學成分及細胞毒殺活性之研究." 碩士, 輔英科技大學, 1995. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22095FY005527004%22.&searchmode=basic.
Full text米澤, 淳. "白金系抗がん剤の動態特性と腎毒性発現機構に関する研究." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137142.
Full text張, 昀鵬. "シスプラチン特異的腎毒性発現機構の解明に関する研究." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/253235.
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新制・課程博士
博士(薬科学)
甲第22399号
薬科博第121号
新制||薬科||13(附属図書館)
京都大学大学院薬学研究科薬科学専攻
(主査)教授 松原 和夫, 教授 山下 富義, 教授 髙倉 喜信
学位規則第4条第1項該当
Doctor of Pharmaceutical Sciences
Kyoto University
DFAM
中村, 任. "バンコマイシンの腎排泄挙動と腎毒性発現機構に関する研究." 京都大学 (Kyoto University), 1999. http://hdl.handle.net/2433/182023.
Full text白川, 久志. "大脳皮質におけるニューロアクティブステロイドによる興奮性神経毒性の制御機構に関する研究." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/73179.
Full text宮下, 正弘. "宿主特異的毒素AM-toxin類縁体の合成と構造活性相関." 京都大学, 1998. http://hdl.handle.net/2433/78089.
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新制・課程博士
博士(農学)
甲第7564号
農博第1025号
新制||農||772(附属図書館)
学位論文||H10||N3214(農学部図書室)
UT51-99-A250
京都大学大学院農学研究科農芸化学専攻
(主査)教授 上野 民夫, 教授 岩村 俶, 教授 桒原 保正
学位規則第4条第1項該当
谷, 修祐. "鉛の神経毒性に着目したヒト健康リスク評価手法の構築." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142200.
Full textYang, Yongkui. "Aggregation, adsorption and toxicity of fullerene C60 nanoparticles in the activated sludge process." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/174905.
Full text藤本, 真二. "出血性脳障害誘発因子としてのセリンプロテアーゼによる神経毒性発現機序に関する研究." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137136.
Full text優樹, 角谷, and Yuki Kadoya. "がん細胞選択的細胞死の誘導を目的とした高いDNA切断活性を有する新規二核銅(II)錯体の開発に関する研究." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13158496/?lang=0, 2021. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13158496/?lang=0.
Full text上園, 崇. "パーキンソン病発症物質としての内因性神経毒β-カルボリンに関する研究." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150434.
Full text王臻雅 and Jen-ya Wang. "沙門氏桿菌感染巨噬細胞的發炎反應及其細胞毒性之研究." 碩士, 輔英科技大學, 1997. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22097FY005527003%22.&searchmode=basic.
Full text義本, 裕介. "サソリ由来の殺虫性ペプチド毒素ならびに表皮蛍光物質の構造解析." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263715.
Full text北村, 朗. "フォールディング異常によるタンパク質凝集 : 細胞質シャペロニンによるその毒性阻止機構." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136941.
Full textHuang, Zhao Bin, and 黃招斌. "以微生物毒性試驗法評估工業廢水毒性之研究." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/20670240615043492449.
Full textLi, Han Lang, and 李漢郎. "積體電路製造業:廢水生物毒性分析及處理減毒性探討." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/43178982871771442016.
Full textYUAN, YOU-GANG, and 袁又罡. "銅對烏魚(MugilcephalusIinnaeus)之急慢性毒性的影響." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/45060267523525272413.
Full textYuan, You-Gang, and 袁又罡. "銅對烏魚(MugilcephalusIinnaeus)之急慢性毒性的影響." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/11439262233493599909.
Full textGAO, YOU-XIN, and 高又新. "土壤中酚酸的毒性行為." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/79487950183549553342.
Full textZHONG, YU-WEN, and 鍾郁文. "Edwardsiella tarda外毒素之磷脂 活性." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/22701181394328265817.
Full textHE, ZHONG-YANG, and 何忠陽. "染料成分之厭氣生物分解性及毒性." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/82592998166272087983.
Full textZHAO, HUAN-PING, and 趙煥平. "廢水水質特性對毒性物質揮發之影響." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/36339467521509115161.
Full textHUANG, HONG, and 黃弘. "豬假性狂犬病毒分離株變異性的研究." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/59470407725602444526.
Full textHsien, Chang Shao, and 張紹先. "施用毒品行為可罰性之研究." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/78536113983653982343.
Full text佛光大學
公共事務學系
96
Recently we can see in the media as well as the newspapers that a lot of famous actors cause a serial of social news initiated by drug case including apologizing to the crowd. It shows that has extremely repentant purpose to oneself by making this kind of mistake and hope everybody can offer them a chance to correct their manners and so on. Such as like the apology. Herein, I wonder in my own heart, the victim that takes drug is oneself should pardon to oneself not apologize to the people. Does the crime mean that make a mistake? But the behavior of drugging to oneself that they can regard as the behavior of a kind of crime in the long run that many questions is worthy of pondering behind the issue. This mainly discussion of the research that the point of penalty about the behavior of using drugs at present in our country that its purpose can hope that via various criminal policy law science books, relevant literature analysis, in order to probe the concept of the drugs crime, analyze our country's present constitution, judicial organ lord chancellor explain, the drugs endanger and prevent and cure regulations, criminal law, criminal policy, and relevant measures of rescuing, and study as well as dissect about relevant academic periodicals that the norm of the drugs endanger and the theory between advantage and disadvantage , provide the relevant improvement and suggestion. In our country, focus on the behavior of using the drugs from severe punishment consciousness in the past to the provision that the drugs endanger and the crime prevention act in the present, the performance of penalty don’t execute the drugs crime well than before, the reason that change of the criminal policy in our country that probe into it whether have punishment for the behavior of taking drugs from the criminal legislative policy aspect in this point of the issue. Therefore, we hope that about drug question is equal as the mode of thought in the crime problem via the issue. In terms of individual, society and country, discuss as the starting point, and offer the suggestion that improve in the relevant correction supplementary measure of our country at present in the country.
WU, HONG-LIN, and 吳鴻林. "GENTAMICIN 肌肉注射對豬之短期毒性." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/32376973417649463976.
Full textWang, Jin Mei, and 王錦梅. "一氧化氮(NO)毒性機制之探討." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/82311200620829402958.
Full textPENG, NAN-HONG, and 彭南弘. "動態河川毒性物質解析模式." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/25522920041069825716.
Full textLIN, TONG-LONG, and 林統隆. "代表性尿毒素在活性炭顆粒上之吸附研究." Thesis, 1986. http://ndltd.ncl.edu.tw/handle/46825555755413925413.
Full textLiao, wen-ling, and 廖文伶. "性別與慢性B型肝炎病毒感染易感受基因之相關性." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/34604612351305110632.
Full text國立臺灣大學
流行病學研究所
88
Abstract Background: Numerous clinical and epidemiological observations have shown that males are more susceptible to hepatitis B virus (HBV) infection and chronic HBV disease than females. Previous studies have also shown that children born to carrier parents are more likely to be male. Moreover, the existence of a genetic basis for susceptibility to chronic HBV infection has gained increasing acceptance. Based on the observational information, we propose a hypothesis that susceptible gene(s) for chronic HBV infection may be located on the sex chromosomes. Aims: Part I: To verify that HBV carrier parents bear mostly male offspring in Taiwan. Part II: To identify susceptible gene(s) of chronic HBV infection on X chromosome by genomic screening using microsatellite markers. Part I: Number of male and female offspring according to parental HBsAg serological statues Study design: In this questionnaire survey, 251 married males and 407 married females, around 20-35 years of age, were recruited from MJ health screening center. The female spouses’ pregnancy history, including number of pregnancy, offspring, and abortion is collected by a structured questionnaire and parental HBV serological status is provided by medical records of the MJ Health Screening Centers. Results: Parental HBV serological status does not affect the number of male offspring; the number of female offspring for each carrier mother is significantly fewer than that of non-carrier mothers (chi-square test, p=0.01). The carrier fathers also have fewer daughters than non-carrier fathers, but the difference dose not reach statistic significance (p=0.25). Part II: A genome wide screening of X-chromosome Study design : This case-control study is divided into two parts. In the stage I analysis, we studied 86 vaccinated children, including 35 carriers and 51 non-carriers, by chromosome-wide screening using 15 microsatellite markers on X chromosome. According to the results of the first stage analysis, we focus on two loci and study additional 231 vaccinated children using 6 selected markers that are within 1-10 cM apart. Results: One marker near the q 21.33 of X chromosome shows a significant difference in allele distribution among cases and both control groups. Conclusion: Our data strongly suggest the existence of a susceptible gene to chronic HBV infection on X chromosome. This finding, if fully substantiated, would be of value to the development of targeted interventions for HBV control. Key word: hepatitis B virus, sex ratio, case control study, vaccination, genomic screening, susceptibility, genetic epidemiology
TANG, TENG-YU, and 唐登友. "毒性化學物質管理之法制研究." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/uetxd2.
Full textjolan, wei, and 韋若蘭. "成年吸毒者吸毒涉入強度、自我控制、非理性信念與再吸毒意向之關係研究." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/30260177522092715794.
Full textYang, Jui-mei, and 楊瑞美. "毒品政策對施用毒品者之影響--以某成年男性戒治所為例." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/28289705150561021605.
Full textGao, Jia Ze, and 高嘉澤. "Methyl methacrylic acid對哺乳類細胞的毒性研究." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/00849377193699081921.
Full textLIN, XIN-LONG, and 林興龍. "無毒性混煉配料對聚氯乙烯擠壓加工性之影響." Thesis, 1986. http://ndltd.ncl.edu.tw/handle/27567217934199761639.
Full textYang, Wei-Lei, and 楊偉磊. "PKB/Akt激對MNNG誘發之細胞毒性與致突變性的影響." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/92686705955143154514.
Full text國立清華大學
生命科學系
89
Alkylating agent N-methyl-N’-nitro-N-nitroso-guanidine (MNNG) forms a structurally diverse population of alkyl-DNA adducts. The O6-methylguanine induced by MNNG is the most significant adduct causing cytotoxicity and mutagenicity. This adduct is repaired by O6-methylguanine-DNA methyltransferase (MGMT) in cells. Previous studies have indicated that alkylating agents can also induce signal transduction pathways, suggesting that signal transduction pathways may be associated with DNA repair systems. We have adopted the MGMT highly expressed Chinese hamster ovary cells (phenotype Mer+, AGT) and the MGMT deficient parental cells (phenotype Mer-, CHOM) to investigate whether MGMT is involved in the regulation of signaling pathways induced by MNNG. We have also investigated the roles of MNNG-induced signals in cytotoxicity and genotoxicity. CHOM cells exhibit higher levels of endogenous phospho-Akt than AGT cells. MNNG significantly induced phospho-Akt in AGT cells, conversely it decreased the levels of phospho-Akt by in CHOM cells. These phenomena are also observed in Mer+ and Mer- human fibroblasts HFW and GM0011, respectively. MNNG did not elicit ERK and p38 MAPK signals nor did it alter the expression of PTEN, a PI3 kinase phosphatase, in both AGT and CHOM cells. Co- administrating Wortmannin or LY294002, PI3-kinase inhibitors, increased cytotoxicity and decreased mutagenicity induced by MNNG in AGT cells. Okadaic acid, a protein phosphatase inhibitor, markedly elevated the levels of phospho-Akt, and decreased cytotoxicity and mutagenicity induced by MNNG in CHOM cells. The results suggest that in Mer+ cells the activity of Akt may be negatively regulated by MGMT, which must conduct DNA repair upon MNNG exposure and thereby leave the Akt negative control complex to allow increase of Akt activity. In Mer- cells, low MGMT enables the endogenous Akt activity maintained at high levels, which may be decreased by other negative control mechanism such as phosphatase elicited upon MNNG exposure. Akt signal protects MNNG-induced cytotoxicity in both Mer+ and Mer- cells. However, in Mer+ cells Akt activity may elicit "error-prone" repair or replication pathways and subsequently increase mutation frequency. Conversely, supplement Akt activity can decrease mutagenesis in Mer- cells. The results suggest that Akt signal transduction pathway is a key regulator in controlling DNA repair, replication and mutagenesis in MNNG-treated cells.
HUANG, JUN-CHANG, and 黃蕙琳. "蛇毒磷酯�失秖慾壯K疫交叉反應性." Thesis, 1986. http://ndltd.ncl.edu.tw/handle/48880365452961224100.
Full textXU, SHU-ZHI, and 徐淑芷. "毒性化學物質運作管理模式之探論." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/76166930405564600178.
Full text陳冠州. "痢疾桿菌Shigellaflexneri自發性抗藥性質體變異株與自發性毒性質體變異株的分析." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/38866676204092335511.
Full text國立中興大學
分子生物學研究所
92
Forty-two Taiwan isolates and 1 ATCC isolate of Shigella flexneri were collected and their minimum inhibitory concentrations (MIC) of ampicillin, streptomycin and nalidixic acid were determined. The results showed that MIC of ampicillin and streptomycin for the 42 Taiwan isolates were 64 - 512 μg/ml and 128 - 512 μg/ml, respectively, whereas MIC of ampicillin and streptomycin for the ATCC isolate were 2 and 8 μg/ml, respectively. On the other hand, only 1 Taiwan isolate had MIC of nalidixic acid to be 1024 μg/ml. Except for this Taiwan isolate, MIC of nalidixic acid for all other Taiwan isolates and the ATCC isolate were 1 μg/ml. In the previous study, one Taiwan isolate (SH595) was picked and a resistant plasmid (R plasmid) responsible for its resistance to ampicillin and streptomycin was identified. In addition to the R plasmid, SH595 carried 4 cryptic small plasmids and one large plasmid likely involved in its virulence. SH595 had MIC of streptomycin to be 128 μg/ml. Many plasmid mutants resistant to streptomycin of 200 μg/ml were selected. These plasmid mutants could be grouped into two types. The type 1 mutants had an insertion of either a 15-kb or 26-kb Tn21-like transposon in one of the four cryptic small plasmids. The Tn21-like transponson was likely originated from the R plasmid in SH595. The type II mutants had an extra 40-kb plasmid, with the 6 endogeneous plasmids seemingly unchanged in size (Wang, 2002; Chen, 1999). In this study, the 40-kb plasmid was transformed into E. coli and analyzed by PCR, Southern hybridization, sequencing and restriction analysis. The results indicated that the plasmid consists of a 36-kb Tn21-like transposon and a 4-kb sequence containing a ColE1 origin of replication. It seems that SH595 contained a cryptic low-copied or undetectable 4-kb plasmid in the bacteria. An insertion of the 36-kb Tn21-like transposon in this plasmid resulted in generation of the type II mutant which showed enhanced resistance to streptomycin. The relationship between the R plasmid and the three Tn21-like transposons (15-kb, 26-kb and 36-kb) awaits further study. In the second part of this study, another class of plasmid mutants of S. flexneri was studied. Plasmid mutants from two Taiwan isolates (SH2308 and SH2576) were selected by loss of the capabilities of congo red binding. One SH2308 plasmid mutant and 3 SH2576 plasmid mutants were selected for further PFGE and Southern analyses. The SH2308 mutant lost a large plasmid completely, whereas two SH2576 mutants had a large plasmid, similar in size to that in SH2308, integrated into the chromosome in different locations. The other SH2576 mutant had a further deletion after integration of the same large plasmid in the chromosome. SH2308 and SH2576 both showed multiplication after infection into human macrophage cells and had cytotoxicity toward the cells. But the four mutants lose the multiplication ability and cytotoxicity. The large plasmid in SH2308, and likely the large plasmid in SH2576, could be defined as the virulence plasmid.
Tsao, Chen-Yun, and 曹承允. "兩岸合作防制毒品危害可行性之研究." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/73389100981162882181.
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