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Journal articles on the topic '2-Chloro-3-formyl-quinoline'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Peerzade, Nargisbano A., Shravan Y. Jadhav, and Raghunath B. Bhosale. "Synthesis and Biological Evaluation of Some Novel Quinoline based Chalcones as Potent Antimalarial, Anti-inflammatory, Antioxidant and Antidiabetic Agents." Asian Journal of Chemistry 32, no. 4 (2020): 959–64. http://dx.doi.org/10.14233/ajchem.2020.22542.

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The objective of the present study was to synthesize a series of some novel quinoline based methoxy substituted chalcones and to evaluate their in vitro antimalarial, anti-inflammatory, antioxidant and antidiabetic activitites. The quinoline based chalcones was synthesized by condensation of 2-chloro-3-formyl qunoline with various methoxy substituted acetophenone in presence of NaOH. The Claisen-Schmidt condensation gave high yield of quinoline based chalcones. Synthesis of 2-chloro-3-formyl quinoline was carried out by Vilsmeir-Haack reaction on acetanilide and 4-methoxy acetanilide which on

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2

Mashelkar, Uday, Mukesh Jha, and Beena Mashelkar. "Synthesis of 2-azetidinones substituted quinoline derivative." Journal of the Serbian Chemical Society 78, no. 5 (2013): 621–25. http://dx.doi.org/10.2298/jsc120617081m.

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Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90?C and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones.

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3

Selvaraj, Mohana Roopan, Rahman Nawaz Khan Fazlur, and Elango Ganesh. "Antidermatophytic studies of some 2-chloro-quinoline analogues." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 851–53. https://doi.org/10.5281/zenodo.5636290.

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Chemistry Research Laboratory, Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail </em>: nawaz_f@yahoo.co.in, mohanaroopan.s@vit.ac.in In this study, a series of 2-chloro-quinoline-3-carbaldehydes (1a-g) and (2-chloro-quinolin-3-yl)-methanols (2ag) were tested for their antidermatophytic studies against four species of dermatophytes : <em>T. rubrum</em>, <em>E. floccosum</em>, <em>T. mentagrophytes</em> and <em>M. gypseum</em> by well diffusion method. Compounds 1c, 1e and 2a

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4

Parab, R. H., and B. C. Dixit. "Synthesis, Characterization and Antimicrobial Activity of Imidazole Derivatives Based on 2-chloro-7-methyl-3-formylquinoline." E-Journal of Chemistry 9, no. 3 (2012): 1188–95. http://dx.doi.org/10.1155/2012/164235.

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A series of oxazole and thereof imidazole derivatives were prepared from 2-chloro-7-methyl-3-formyl quinoline. The structures of all synthesized compounds were elucidated by elemental, IR,1HNMR,13CNMR spectra. Supplementary to these, they were assayedin vitrofor their antimicrobial activity; it was revealed that some synthesized derivatives were exhibiting competent biological activity against both gram negative and gram positive bacterial species and fungal microorganisms.

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5

Ayoob, Ala, and Fatma Mohmood. "Synthesis of some new heterocyclic compounds derived from 2-Chloro-3-formyl quinoline." JOURNAL OF EDUCATION AND SCIENCE 26, no. 5 (2013): 75–85. http://dx.doi.org/10.33899/edusj.2013.163057.

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6

Beg, Nawaj Ali, and Maqdoom Farooqui. "Facile Synthesis of New Substituted 4-Thiazolidinones Conjugates containing Quinoline-Sulfamethoxazole Motifs and their Bioevaluation." Asian Journal of Chemistry 37, no. 2 (2025): 455–64. https://doi.org/10.14233/ajchem.2025.33177.

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Difunctional Brönsted acidic ionic liquid [DBN][HSO4] mediated synthesis of quinoline-sulfamethoxazole blended 4-thiazolidinones derivatives (7a-l) by reacting 4-amino-N-(5-methylisoxazol-3-yl) benzenesulfonamide (4), 2-chloro-3-formyl quinoline (5a-l) and mercapto acetic acid (6) in promising yields at 80 ºC. All the newly synthesized quinoline-sulfamethaoxazole incorporated 4-thiazolidinones derivatives were explored for their in vitro antifungal and antioxidant activity. The novel compounds, 4-thiazolidinones hybrids were evaluated against various fungal strains and compounds 7g, 7h, 7i, 7j

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7

Farrayeh, Batool A., Mustafa M. El-Abadelah, Jalal A. Zahra, Salim F. Haddad, and Wolfgang Voelte. "Heterocycles [h]-Fused onto 4-Oxoquinoline-3-carboxylic Acid. Part X [1]. Synthesis and X-Ray Structure of a Model 4- Oxo[1,4]benzoxazepino[2,3-h]quinoline-3-carboxylic Ester." Zeitschrift für Naturforschung B 68, no. 2 (2013): 187–94. http://dx.doi.org/10.5560/znb.2013-2270.

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Direct interaction of salicylaldehyde oxyanion with ethyl 7-chloro-8-nitro-4-oxoquinoline-3- carboxylate (2) delivered the respective 7-(2-formyl-phenoxy)-8-nitro-4-oxoquinoline-3-carboxylic ester 3. Reductive cyclization of 3 furnished the corresponding 4-oxo-[1,4]benzoxazepino[2,3- h]quinoline-3-carboxylic ester 5. Acid-catalyzed hydrolysis of the esters 3/5 produced the respective acids 4/6. Structural assignments for the new compounds 3 - 6 are supported by microanalytical and spectral (IR, HRMS, NMR) data and confirmed by X-ray structure determination for compound 5. Interestingly, compou

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8

Nayak, Govind, Birendra Shrivastava, and Akhlesh Singhai. "Synthesis and Antimicrobial Activity of Azetidin-2-One Fused 2-Chloro-3-Formyl Quinoline Derivatives." Oriental Journal of Chemistry 32, no. 4 (2016): 1977–82. http://dx.doi.org/10.13005/ojc/320423.

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9

Heravi;, Majid M., M. Shiri, Heravi M. Momahed, et al. "Pseudo-five-component condensation for the diversity-oriented synthesis of novel indoles and quinolines containing pseudo-peptides (tricarboxamides)." Iranian Journal of Chemistry and Chemical Engineering 37, no. 4 (2018): 101–15. https://doi.org/10.5281/zenodo.4052265.

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A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH<sub>2</sub>Cl<sub>2</sub> at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Part

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10

Prasanna, B. M., B. M. Praveen, Narayana Hebbar, T. V. Venkatesha, and H. C. Tandon. "Inhibition study of mild steel corrosion in 1 M hydrochloric acid solution by 2-chloro 3-formyl quinoline." International Journal of Industrial Chemistry 7, no. 1 (2015): 9–19. http://dx.doi.org/10.1007/s40090-015-0064-6.

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11

Saleh, Fahad T., Abdul Ahad, Prashant D. Netankar, Anis A. Sheikh, and Syed U. K. Asema. "Synthesis of Some Quinoline Oximes by an Efficient Method and their Biological Screening." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 05 (2023): 591–96. http://dx.doi.org/10.25004/ijpsdr.2023.150506.

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Quinoline scaffolds have gained substantial interest in the modern era of medicinal chemistry due to their wide range of biological applications. The present work reported the synthesis of various oxime derivatives of quinolines by the reaction of substituted 2-chloro-3-formyl-quinolines with hydroxyl amine hydrochloride. The reaction was mediated by aqueous ethanol, whereas hexamine was used as an efficient, non-toxic and easily available basic organocatalyst. The developed protocol has various advantages, including operational ease, affordability, an eco-friendly approach, and short reaction

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12

Karekal, Mahendra Raj, Vivekanand Biradar, and Mruthyunjayaswamy Bennikallu Hire Mathada. "Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties." Bioinorganic Chemistry and Applications 2013 (2013): 1–16. http://dx.doi.org/10.1155/2013/315972.

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A new Schiff base of 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide and 3-formyl-2-hydroxy-1H-quinoline (HL), and its Cu(II), Co(II), Ni(II), Zn(II), Cd(II), and Hg(II) complexes have been synthesized and characterized in the light of microanalytical, IR,H1NMR, UV-Vis, FAB-mass, ESR, XRD, and TGA spectral studies. The magnetic susceptibility measurements and low conductivity data provide evidence for monomeric and neutral nature of the complexes. On the basis of spectral studies and analytical data, it is evident that the Schiff base acts as tridentate ligand. The Cu(II), Co(II), and Ni(II) co

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13

Morteza, Shiri, Heravi Majid Momahed, Vahideh Zadsirjan, and Arani Atefeh Najatinezhad. "Pseudo-five-component condensation for the diversity-oriented synthesis of novel indoles and quinolines containing pseudo-peptides (tricarboxamides)." Iranian Journal of Chemistry and Chemical Engineering 37, no. 4 (2020): 101–15. https://doi.org/10.5281/zenodo.4161795.

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Abstract:

A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Particularly, a number of s

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14

Abdel-Baky, Yasser M., Ahmed M. Omer, Esmail M. El-Fakharany, Yousry A. Ammar, Moustafa S. Abusaif, and Ahmed Ragab. "Developing a new multi-featured chitosan-quinoline Schiff base with potent antibacterial, antioxidant, and antidiabetic activities: design and molecular modeling simulation." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-50130-3.

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AbstractA new chitosan Schiff base was developed via the reaction of chitosan (CH) with 2-chloro-3-formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and morphology of CHQ derivative was confirmed by 1H NMR, FT-IR spectroscopy and SEM analysis. The antibacterial activity was considerably promoted with increasing quinoline concentration up to 1 M with maximal inhibition reached 96 and 77% against Staphylococcus haemolyticus and Escherichia coli, respectively. Additionally, CHQ derivative afforded higher ABTS·+ radical scavenging activity reached 59% compared to 1

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15

Saleh, Mohanad, Ala Ayoub, and Ali Hammady. "Synthesis biological studies of some new heterocyclic compound derived from 2-chloro-3-formyl quinoline and 4-(benzyl sulfonyl) acetophenone." Egyptian Journal of Chemistry, June 6, 2020, 0. http://dx.doi.org/10.21608/ejchem.2020.26354.2535.

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16

KUMAR, VIPIN, Shubham Sharma, Vaishali ., Dharmender Singh, Chandi C. Malakar, and Virender Singh. "Exploration of Synthetic Potential of 2‐Chloro‐Quinoline‐3‐Carbaldehyde." European Journal of Organic Chemistry, July 15, 2024. http://dx.doi.org/10.1002/ejoc.202400456.

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Quinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. Specifically, quinoline is renowned antimalarial agents from several past decades and showed strong potential in this field. 3‐Formyl‐quinoline is a versatile precursor which transformed through the several easy methods into a wide range of biologically valuable scaffolds. The exploration of 3‐formyl‐quinoline gained much more attention to medicinal chemists in the field of drug discovery to design and synthesize new fused/tethere

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