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Relevant bibliographies by topics / 2 chloroquinoline 3 carbaldehyde derivative

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Academic literature on the topic '2 chloroquinoline 3 carbaldehyde derivative'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "2 chloroquinoline 3 carbaldehyde derivative"

1

Arsanious, Mona, Shaban Darwish, El-Sayed Shalaby, and Dina El-Ghwas. "Synthesis, X-ray, DFT Studies and Antimicrobial Properties of New Quinolinylphosphonates." Letters in Organic Chemistry 16, no. 8 (2019): 668–75. http://dx.doi.org/10.2174/1570178616666181231161801.

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The phosphorus atom in hexamethyl phosphorus triamide 5 attacks the carbonyl function in 2-chloroquinoline-3-carbaldehyde 4a to give the bis-quinolinyl ethanone product 6. On the other hand, quinoline ring-attack proceeds by the same phosphorus reagent upon reaction with 2-chloroquinoline- 3-aldoxime 4b yielding phosphonate 7. Meanwhile, the reaction of the tris-aminophosphine reagent 5 with 2-chloroquinoline- 3-(p-chlorophenyl)imine 4c affords the respective α-aminophosphonate 8. Moreover, the attack by phosphine 5 on 2-chloroquinoline-3-imines 4d and 4e produces the respective cyclic azophos

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2

Salem, Mohammed A., Moustafa A. Gouda, and Ghada G. El-Bana. "Chemistry of 2-(Piperazin-1-yl) Quinoline-3-Carbaldehydes." Mini-Reviews in Organic Chemistry 19, no. 4 (2022): 480–95. http://dx.doi.org/10.2174/1570193x18666211001124510.

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Abstract: This review described the preparation of 2- chloroquinoline-3-carbaldehyde derivatives 18 through Vilsmeier-Haack formylation of N-arylacetamides and the use of them as a key intermediate for the preparation of 2-(piperazin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2- (piperazin-1-yl) quinolines derivatives was explained through the following chemical reactions: acylation, sulfonylation, Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction and Kabachnik-Field’s reaction.

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3

Bonyad, Ali Moin. "Synthesis of Chalcones from Acetone and tetrazole and 2-acetyl naphthalene Assisted by Microwave." Engineering and Technology Quarterly Reviews 3, no. 1 (2020): 16–22. https://doi.org/10.5281/zenodo.3686827.

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In the present study, we understood the total synthesis one chalcone derivative via Claisen-Schmidt condensation of the respective aldehydes and ketones using Microwave assisted irradiation method. In the microwave environment, chemical reactions usually proceed faster and give higher yields with fewer by- products. In the synthesis, a common aldehyde namely tetrazolo {1, 5-a} quinoline-4-carbaldehyde was used while the ketones used were respectively acetone, 2- acetyl Naphthalene. The Chalcone synthesised from Tetrazolo {1, 5-a} quinolone-4-carbaldehyde and acetone was 4-(tetrazolo {1, 5-a} q

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4

Morteza, Shiri, Heydari Masumeh, and Zadsirijan Vahideh. "Efficient synthesis of novel functionalized pyrazolo-pyranoquinoline and tetrahydrodibenzo-[1,8]naphthyridinone derivatives." Tetrahedron 73, no. 15 (2017): 2116–22. https://doi.org/10.1016/j.tet.2017.02.064.

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The facile and efficient synthesis of 1,4-dihydropyrazolo-pyrano-[2,3-b]quinoline derivatives from the reaction of 2-chloroquinoline-3-carbaldehydes and pyrazolones is described. Moreover, a one-pot method for the development of functionalized tetrahydrodibenzo[b,g][1,8]naphthyridinone derivatives is reported by using a threecomponent reaction of 2-chloroquinoline 3-carbaldehydes, pyrazolone, and enaminones catalyzed by L-proline in EtOH.

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5

Kumara, Tholappanavara H. Suresha, Gopalpur Nagendrappa, Nanjappa Chandrika, et al. "Reactions between arylhydrazinium chlorides and 2-chloroquinoline-3-carbaldehydes: molecular and supramolecular structures of a hydrazone, a 4,9-dihydro-1H-pyrazolo[3,4-b]quinoline and two 1H-pyrazolo[3,4-b]quinolines." Acta Crystallographica Section C Structural Chemistry 72, no. 9 (2016): 670–78. http://dx.doi.org/10.1107/s205322961601278x.

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Hydrazone derivatives exhibit a wide range of biological activities, while pyrazolo[3,4-b]quinoline derivatives, on the other hand, exhibit both antimicrobial and antiviral activity, so that all new derivatives in these chemical classes are potentially of value. Dry grinding of a mixture of 2-chloroquinoline-3-carbaldehyde and 4-methylphenylhydrazinium chloride gives (E)-1-[(2-chloroquinolin-3-yl)methylidene]-2-(4-methylphenyl)hydrazine, C17H14ClN3, (I), while the same regents in methanol in the presence of sodium cyanoborohydride give 1-(4-methylphenyl)-4,9-dihydro-1H-pyrazolo[3,4-b]quinoline

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6

Gangadhara, Angajala, and Subashini R. "Synthesis and docking studies of novel quinoline substituted thiobarbituric acid derivatives as potential therapeutic agents for type-II diabetes." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 918–20. https://doi.org/10.5281/zenodo.5637670.

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Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail </em>: dr.subashini.r@gmail.com In the present work novel 5-((2-chloroquinolin-3-yl)methylene)-dihydro-2-thioxopyrimidine-4,6(1<em>H</em>,5<em>H</em>)-dione derivatives were synthesized by Knoevenagel condensation of 2-chloroquinoline-3-carbaldehyde with thiobarbituric acid. The synthesized compounds were successfully characterized by FTIR, <sup>1</sup>H NMR and <sup>13</sup>C NMR. Further comparative docking studies were carried out to find out t

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7

Morteza, Shiri, Notash Behrouz, Zamanian Fatemeh, Yasaei Zahra, and Ranjbar Maryam. "Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides." Organic and Biomolecular Chemistry 15, no. 47 (2017): 10073–81. https://doi.org/10.1039/c7ob02043k.

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A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pdcatalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C–C, C–N, and C–O bonds in a one-pot procedure.

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8

Abdi, Bayan, Mona Fekadu, Digafie Zeleke, Rajalakshmanan Eswaramoorthy, and Yadessa Melaku. "Synthesis and Evaluation of the Antibacterial and Antioxidant Activities of Some Novel Chloroquinoline Analogs." Journal of Chemistry 2021 (December 30, 2021): 1–13. http://dx.doi.org/10.1155/2021/2408006.

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Quinoline heterocycle is a useful scaffold to develop bioactive molecules used as anticancer, antimalaria, and antimicrobials. Inspired by their numerous biological activities, an attempt was made to synthesize a series of novel 7-chloroquinoline derivatives, including 2,7-dichloroquinoline-3-carbonitrile (5), 2,7-dichloroquinoline-3-carboxamide (6), 7-chloro-2-methoxyquinoline-3-carbaldehyde (7), 7-chloro-2-ethoxyquinoline-3-carbaldehyde (8), and 2-chloroquinoline-3-carbonitrile (12) by the application of Vilsmeier–Haack reaction and aromatic nucleophilic substitution of 2,7-dichloroquinoline

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9

Potdar, Vaibhav V., Arun B. Joshi, and Himanshu Joshi. "Synthesis, Antibacterial Screening and ADME Prediction of Novel Ester Derivatives of 6-Substituted-2-chloroquinoline-3-carbaldehyde." Asian Journal of Chemistry 36, no. 7 (2024): 1518–22. http://dx.doi.org/10.14233/ajchem.2024.31503.

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In this research, a series of novel 2-chloroquinoline-3-carbaldehyde analogues (4a-f) were successfully synthesized by employing several acetanilides in combination with hydrazides and acyl chlorides. The methodology yielded compounds with distinct substitutions, thus expanding the chemical diversity of this class of compounds. Characterization through FT-IR, 1H NMR, 13C NMR and mass spectral analysis confirmed the structural integrity of the synthesized derivatives. The ADME study indicates that the synthesized compounds were found to be possessing reliable ADME properties. The antimicrobial

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10

Sangula, Vara Satish, and Paul Douglas Sanasi. "Green Synthesis of N-Aryl, 2-(Chloroquinoline)-4-Thiazolidinone Derivatives using Magnetically Separable Copper Oxide Nano Particles and their Anti-Cancer Activity Studies." Research Journal of Chemistry and Environment 27, no. 12 (2023): 12–23. http://dx.doi.org/10.25303/2712rjce012023.

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Multi-component one-pot synthesis of biologically active heterocyclic compounds has been prevailing as a potential methodology to meet the therapeutic requirements of the pharmaceutical industry. On this background, a facile one-pot green synthesis of Nsubstitutedaryl- 2-(chloroquinoline)-4-thiazolidinone derivatives (4a-h) was conducted with a mixture of 2- chloroquinoline-3-carbaldehyde (1), thioglycolic acid (2) and various aromatic amines (3a-h). The reaction involved cyclo-condensation mechanism catalyzed by the synthesized CuO NPs which were obtained through hydrothermal method. These NP

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