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Journal articles on the topic '3-dione derive'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Johns, SR, JA Lamberton, TC Morton, H. Suares, and RI Willing. "Campnosperma Exudates. The Optically Active Long Chain 5-Hydroxycyclohex-2-Enones and Long-Chain Bicyclo[3.3.1]Nonane-3,7-Diones." Australian Journal of Chemistry 40, no. 1 (1987): 79. http://dx.doi.org/10.1071/ch9870079.

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Re-examination of the optically active long-chain 5-hydroxycyclohex-2-enones of Campnosperma species has confirmed the former structural assignments, except that in Tigaso oil both the 5- hydroxycyclohex-2-enones and the phenolic components contain a significant (35-40%) proportion of compounds with di-unsaturation in the C19-chain. Further study has been made of the conversion of (-)-endo-4-hexadecyl-l-hydroxybicyclo[3.3.l]nonane-3,7-dione (10) into a mixture of an optically inactive and optically active β- diketones. The major product from this reaction is (�)-5-(1-acetylheptadecy1)cyclohexa

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2

Tran, Hieu Quang, Hien Cao Nguyen, Thin Van Nguyen, Thanh Thi Nguyen, Toan Ngoc Vo, and Cong Tien Nguyend. "Synthesis and Evaluation of Cytotoxic Activity on Mcf-7 Cell Line of Some Diesters Derived from 5-(Hydroxybenzylidene)Thiazolidine-2,4-Diones." Acta Chemica Iasi 26, no. 2 (2018): 233–48. http://dx.doi.org/10.2478/achi-2018-0015.

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Abstract Knoevenagel condensation of thiazolidine-2,4-dione, which were prepared from chloroacetic acid and thioure by 1,3 dipolar cycloaddition reaction, with 2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and 4-hydoxy-3-methoxybezaldehyde gave five corresponding 5-(hydroxybenzylidene)thiazolidine-2,4-dione compounds. The reaction of 5-(hydroxybenzylidene)thiazolidine-2,4-diones and ethyl chlorofomate or ethyl chloroacetate occurred at both NH and OH centers and gave ten corresponding diesters. The structures of the diesters were confirmed b

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3

Possner, Sven T., Frank C. Schroeder, Hans Tore Rapp, Volker Sinnwell, Stefan Franke, and Wittko Francke. "3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea." Zeitschrift für Naturforschung C 72, no. 7-8 (2017): 259–64. http://dx.doi.org/10.1515/znc-2017-0012.

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AbstractA new isoquinoline quinone system and its iodinated derivatives were isolated from the ascidian tunicateAscidia virgineaMüller 1776 (Phlebobranchia: Ascidiidae). Structures were elucidated by spectroscopic methods and derivatization reactions. Ascidine A (3,7-dihydro-1,8-dihydroxy-4-(4′-hydroxyphenyl)isoquinoline-3,7-dione (1), ascidine B (3,7-dihydro-1,8-dihydroxy-4-(4′-hydroxy-3′-iodophenyl)isoquinoline-3,7-dione (2), and ascidine C (3,7-dihydro-1,8-dihydroxy-4-(4′-hydroxy-3′,5′-diiodophenyl)isoquinoline-3,7-dione (3) represent a novel type of tyrosine-derived alkaloids.

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4

Dwivedi, Bhavna, and Dinabandhu Das. "Polymorphism in some new bis-hydrazone compounds." Acta Crystallographica Section C Structural Chemistry 74, no. 12 (2018): 1656–66. http://dx.doi.org/10.1107/s2053229618014286.

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We describe the polymorphism of four new bis-hydrazone compounds, namely butane-2,3-dione 2,3-bis{[bis(4-fluorophenyl)methylidene]hydrazone}, C30H22F4N4 (1), butane-2,3-dione 2,3-bis{[bis(4-chlorophenyl)methylidene]hydrazone}, C30H22Cl4N4 (2), butane-2,3-dione 2,3-bis{[bis(4-methylphenyl)methylidene]hydrazone}, C34H34N4 (3), and butane-2,3-dione 2,3-bis({bis[4-(dimethylamino)phenyl]methylidene}hydrazone), C38H46N8 (4), derived by the condensation reaction between substituted benzophenone hydrazone and butane-2,3-dione. Concomitant polymorphism has been observed in 1, 2 and 3. Overlays of molec

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5

Fan, Ning-Juan, Yuan-feng Li, Shuang Liang, and Jiang-Jiang Tang. "Synthesis and cytotoxic activity of novel steroidal derivatives containing a [1,2,4]triazolo[1,5-a]pyrimidine ring." Journal of Chemical Research 41, no. 7 (2017): 413–15. http://dx.doi.org/10.3184/174751917x14967701767003.

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The synthesis of steroidal derivatives containing [1,2,4]triazolo[1,5- a]pyrimidine derived from progesterone is described. The Claisen condensations of Δ1,4-pregnadien-3,20-dione and 4-chloro-Δ1,4-pregnadien-3,20-dione with dimethyl oxalate afforded 21-methoxalylpregn-1,4-diene-3,20-dione and 4-chloro-21-methoxalylpregn-1,4-diene-3,20-dione, respectively. Furthermore, the reactions of these compounds with 3-amino-1,2,4-triazole yielded the corresponding [1,2,4]triazolo[1,5- a]pyrimidine derivatives. The newly synthesised compounds were evaluated in vitro by means of sulforhodamine B assays fo

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6

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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7

Marcuccio, SM, and JA Elix. "Pyrazine Chemistry. V. Synthesis of Methylanhydropicroroccellin and Dimethylpicroroccellin." Australian Journal of Chemistry 38, no. 12 (1985): 1785. http://dx.doi.org/10.1071/ch9851785.

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The structure of the lichen diketopiperazine, picroroccellin, has been studied by the synthesis of several of its degradation products. The three possible formulations of methylanhydropicroroccellin (3), (4) and (5) were synthesized and from the physical and chemical properties, the former two compounds were shown to be dissimilar from the naturally derived material. Furthermore, the reactivity of the 3- methoxypiperazine-2,5-dione (5) entirely paralleled that reported for picroroccellin and was consistent with the oxygen functions being located at the 3- and 6-positions of the piperazine-2,5-

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8

Londhe, A. V., B. Gupta, S. Kohli, P. Pardasani, and R. T. Pardasani. "Synthesis, Semiempirical, Stereoselectivity and Pharmacological Activity of a New Class of Spiro Pyrrolidine and Isoquinoline Derivatives." Zeitschrift für Naturforschung B 61, no. 2 (2006): 213–20. http://dx.doi.org/10.1515/znb-2006-0217.

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Abstract1,3-Dipolar cycloaddition of azomethine ylides derived from acenaphthylene-1,2-dione and 5- methyl-benzo[b]-thiophene-2,3-dione with L-proline, thiazolidine-4-carboxylic acid and 1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid with various electron deficient dipolarophiles leads to the formation of novel spiroheterocycles having two or more chiral centers. Semiempirical studies have been performed to understand the stereochemical course of the reaction. The synthesized cycloadducts have been screened for antimicrobial and toxicological activity.

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9

Chen, Qinfang, Yihao Pan, Dongxin Zhao, Weiran Yang, and Jing Zheng. "Construct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides." RSC Advances 10, no. 37 (2020): 21895–906. http://dx.doi.org/10.1039/d0ra03919e.

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For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione is reported using Na<sub>2</sub>CO<sub>3</sub> as the base.

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10

Chinh, Pham The, Pham Thi Tham, Duong Huong Quynh, et al. "Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties." Natural Product Communications 16, no. 4 (2021): 1934578X2110100. http://dx.doi.org/10.1177/1934578x211010040.

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Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), a

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11

Collins, DJ, та NE Krause. "Monoacetals Derived From 12-α-Hydroxyandrosta-1,4-diene-3,17-dione and Androsta-1,4-diene-3,12,17-trione". Australian Journal of Chemistry 41, № 6 (1988): 985. http://dx.doi.org/10.1071/ch9880985.

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Conversion of 12α-hydroxyandrosta-1,4-diene-3,17-dione (5) into the corresponding 17-cyclic ethylene acetal (1) was accompanied by acid- catalysed attack of ethylene glycol at C3 to give 17,17-ethylenedioxy- 3-(2′-hydroxyethoxy)-1-methylestra-1,3,5(10)-trien-12a-ol (2), which was the major product with prolonged reaction times. Exchange dioxolanation of androsta-1,4-diene-3,12,17-trione (8), prepared by Jones oxidation of (5), gave selectively the 12-monoacetal (9): the regioisomeric 17-monoacetal (4) was obtained by oxidation of the hydroxy acetal (1) with chromium trioxide in pyridine. The t

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12

Rapacz, Anna, Sabina Rybka, Jolanta Obniska, et al. "Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione." Naunyn-Schmiedeberg's Archives of Pharmacology 389, no. 3 (2015): 339–48. http://dx.doi.org/10.1007/s00210-015-1194-2.

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13

Jiang, Minghua, Senhua Chen, Jing Li, and Lan Liu. "The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms." Marine Drugs 18, no. 2 (2020): 114. http://dx.doi.org/10.3390/md18020114.

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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopia

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14

Ivanov, Anton, Sebastian Boldt, Zaib un Nisa, et al. "Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives." RSC Advances 6, no. 14 (2016): 11118–27. http://dx.doi.org/10.1039/c5ra25558a.

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15

Boitsov, Vitali M., Alexander V. Stepakov, Siqi Wang, et al. "Construction of Spiro[3-azabicyclo[3.1.0]hexanes] via 1,3-Dipolar Cycloaddition of 1,2-Diphenylcyclopropenes to Ninhydrin-Derived Azomethine Ylides." Synthesis 53, no. 12 (2021): 2114–32. http://dx.doi.org/10.1055/a-1360-9716.

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AbstractThe multi-component 1,3-dipolar cycloaddition of ninhydrin, α-amino acids (or peptides), and cyclopropenes for the synthesis of spirocyclic heterocycles containing both 3-azabicyclo[3.1.0]hexane and 2H-indene-1,3-dione motifs has been developed. This method provides easy access to 3-azabicyclo[3.1.0]hexane-2,2′-indenes with complete stereoselectivity and a high degree of atom economy under mild reaction conditions. A broad range of cyclopropenes and α-amino acids have been found to be compatible with the present protocol, which offers an opportunity to create a new library of biologica

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16

Wang, Fa-Zuo, De-Hai Li, Tian-Jiao Zhu, Min Zhang, and Qian-Qun Gu. "Pseurotin A1 and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25." Canadian Journal of Chemistry 89, no. 1 (2011): 72–76. http://dx.doi.org/10.1139/v10-157.

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Two new metabolites containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core, pseurotin A1 (1) and A2 (2), as well as pseurotin A (3), were isolated from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. These compounds were determined using extensive analysis of their spectroscopic data, including 1D and 2D NMR, HR-ESI-MS, and circular dichroism (CD) experiments.

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17

Avdović, Edina H., Danijela L. J. Stojković, Verica V. Jevtić, et al. "Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarin-derived ligand 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione. Crystal structure of the 3-(1-(3-hydroxypropylamino)ethylidene)-chroman-2,4-dione." Inorganica Chimica Acta 466 (September 2017): 188–96. http://dx.doi.org/10.1016/j.ica.2017.06.015.

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18

Kumar, Krishna, Bhuvnesh Singh, Soumyadip Hore, and Ravi P. Singh. "Catalytic enantioselective synthesis of chiral 4-hydroxy 4′-substituted pyrazolones by the vinylogous aldol reaction of pyrazole-4,5-diones with 3-alkylidene-2-oxindoles." New Journal of Chemistry 45, no. 31 (2021): 13747–50. http://dx.doi.org/10.1039/d0nj05886f.

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19

Prager, RH, and P. Razzino. "The Chemistry of 5-Oxodihydroisoxazoles. X. Butyllithium and Lithium Diisopropylamide Promoted Rearrangements of 3-Unsubstituted Isoxazol-5(2H)-ones." Australian Journal of Chemistry 47, no. 9 (1994): 1673. http://dx.doi.org/10.1071/ch9941673.

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The reaction pathway of 3-unsubstituted isoxazol-5(2H)-ones with bases, proposed by Woodman1-3 to proceed via four intermediates to azetidine-2,4-diones, has been confirmed by the isolation of products unequivocally derived from each of the intermediates. Isoxazol-5(2H)-ones substituted on nitrogen by methyl, phenyl, quinolin-2-yl and vinyl groups have been studied. The azetidine-2,4-diones have only been isolated when the intermediate enolate has been alkylated , but only reactive alkyl halides lead to useful syntheses.

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20

Revankar, GR, JO Ojwang, SD Mustain, et al. "Thiazolo[4,5-d]Pyrimidines. Part II. Synthesis and Anti-Human Cytomegalovirus Activity in Vitro of Certain Acyclonucleosides and Acyclonucleotides Derived from the Guanine Analogue 5-Aminothiazolo[4,5-d]Pyrimidine-2,7(3H,6H)-Dione." Antiviral Chemistry and Chemotherapy 9, no. 1 (1998): 53–63. http://dx.doi.org/10.1177/095632029800900102.

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The synthesis and in vitro antiviral activity of certain hydroxyalkoxymethyl, hydroxyalkyl, hydroxyalkenyl and phosphonoalkenyl derivatives of the guanine congener 5-aminothiazolo-[4,5- d]pyrimidine-2,7(3 H,6 H)-dione are reported. The compounds of this study were selected for their structural similarity to acyclonucleosides with known anti-herpesvirus activity. 5-Amino-3-[(Z)-4-hydroxy-2-buten-1-yl]thiazolo[4,5- d]pyrimidine-2,7(3 H,6 H)-dione was the only member of the series to display significant in vitro activity against human cytomegalovirus (HCMV); however, this compound did not inhibit

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21

Piggott, Matthew J., and Dieter Wege. "Some Cycloaddition Reactions of 5,8-Dimethoxynaphtho[2,3-c]furan-4,9-dione." Australian Journal of Chemistry 51, no. 9 (1998): 819. http://dx.doi.org/10.1071/c98031.

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Methylation of 5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione (5) gave, in addition to the title ether (7), the fragmentation products 4-hydroxy-1,5,8-trimethoxy-3-methylnaphthalene-2-carbaldehyde (8) and its methyl ether (9). Addition of benzyne to (7) afforded mainly the expected [4+2] cycloadduct (15) and minor amounts of adduct (16), derived by addition of (7) to (15), and adduct (19), derived by a homo- or 1,3-addition of benzyne to (15), followed by decarbonylation. Adducts of (7) with 1,4-dihydro-1,4-epoxynaphthalene and dimethyl acetylenedicarboxylate also were prepared.

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22

Li, Wei-Guo, and He-Qun Wang. "Design and synthesis of a novel 5-(aminomethylene)thiazolidine-2,4-dione derivatives as potent hepatitis-B virus polymerase inhibitors." Bangladesh Journal of Pharmacology 10, no. 2 (2015): 271. http://dx.doi.org/10.3329/bjp.v10i2.21876.

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<p>A series of novel thiazolidinedione analogues (TZD) were designed and synthesized potent inhibitors of HBV capsid assembly. The synthesis of thiazolidine-2,4-dione derivatives (4a–4o), starting from the condensation of 5-(ethoxymethylene)thiazolidine-2,4-dione (1) with various secondary amines (3) derived from biologically active compounds. The newly synthesized TZD analogues 4a-4o were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and MS and evaluated for their anti-HBV activity. Most of the compounds inhibited the expression of viral antigens at low

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23

Sumathi, S., C. Anitha, P. Tharmaraj та C. D. Sheela. "Spectral, NLO, Fluorescence, and Biological Activity of Knoevenagel Condensate of β-Diketone Ligands and Their Metal(II) Complexes". International Journal of Inorganic Chemistry 2011 (11 січня 2011): 1–8. http://dx.doi.org/10.1155/2011/154326.

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Transition metal complexes of various acetylacetone-based ligands of the type ML (where M= Cu(II), Ni(II), Co(II); L= 3-(aryl)-pentane-2,4-dione) have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, H1NMR, mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are nonelectrolytic in nature. Spectroscopic and other analytical data of the complexes suggest square planar geometry for copper(II), cobalt(II), and nickel(II) complexes of 3-(3-phenylallylidene)pentane-2,4

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24

Hřebabecký, Hubert, Milena Masojídková, Martin Dračínský, and Antonín Holý. "Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol." Collection of Czechoslovak Chemical Communications 71, no. 6 (2006): 871–88. http://dx.doi.org/10.1135/cccc20060871.

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(1R*,2R*,3R*,4R*,5R*,6S*)-3-Amino-5-(benzyloxy)-6-(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol (18) was prepared in seven easy steps from benzyl (1R*,2S*,3S*,4S*)-3-(benzyloxy)bicyclo[2.2.1]hept-5-ene-2-carboxylate (10). Reaction of amine18with ethylN-((2E)-3-ethoxymethacryloyl)carbamate afforded 1-[(1R*,2R*,3R*,4R*,5S*,6R*)-6-(benzyloxy)-3-hydroxy-5- (hydroxymethyl)bicyclo[2.2.1]heptan-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (21) and after deprotection by transfer hydrogenation, free thymine analogue22. The thymine derivative21was converted to 2,3'-anhydronucleoside26. Treatment of the benzyl d

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25

Vetica, Fabrizio, Stephen J. Bailey, Mukesh Kumar, et al. "Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines." Synthesis 52, no. 14 (2020): 2038–44. http://dx.doi.org/10.1055/s-0040-1707472.

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A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities.

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26

Ying, Wei-Wei, Wen-Ming Zhu, Hongze Liang, and Wen-Ting Wei. "Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide." Synlett 29, no. 02 (2017): 215–18. http://dx.doi.org/10.1055/s-0036-1589106.

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A novel strategy has been developed for the synthesis of indoline-2,3-diones through a metal-free radical-coupling reaction. Alkyl radicals derived from indolin-2-ones through a radical-transfer reaction combine with the tert-butylhydroperoxy radical readily generated from commercially available tert-butyl hydroperoxide to afford 3-(tert-butylperoxy)indolin-2-one intermediates that can be further transformed into indoline-2,3-diones under air. This strategy provides a simple and eﬃcient route to the construction of a C=O bond without the use of any metal catalyst or base.

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27

Tao, Huaming, Yunqiu Li, Xiuping Lin, et al. "A New Pentacyclic Ergosteroid from Fungus Aspergillus sp. SCSIO41211 Derived of Mangrove Sediment Sample." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301214.

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Chemical investigation of the fungus Aspergillus sp. SCSIO41211 derived of mangrove sediment sample afforded a ergostane-type pentacyclic steroid, (22 S, 23 R)-12α,14α,23α-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione (1), together with seven known compounds, flavacol (2), aspergilliamide (3), ochratoxin A methyl ester (4), ochratoxin A ethyl ester (5), dihydroaspyrone (6), aspilactonol E (7) and aspilactonol F (8). The structures were determined on the basis of NMR and MS analysis. The isolated compounds were tested for their antiviral activity against H3N2 and EV71 viruses, cytotoxic, a

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28

Butkus, Eugenius, та Birute Bielinyte-Williams. "Divergent Pathways of Reaction Between Cyclohexanone Enamines and α,β-Unsaturated Acid Chlorides". Collection of Czechoslovak Chemical Communications 60, № 8 (1995): 1343–56. http://dx.doi.org/10.1135/cccc19951343.

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The reaction of cyclohexanone enamines with α,β-unsaturated acid chlorides and 2- and 3-chloropropanoyl chlorides under various conditions has been investigated. a,ae-Annulation of enamines Ia-Ie occurs on treatment with chlorides IIa-IId or 3-chloropropanoyl chloride to give bicyclo[3.3.1]nonane-2,9-dione derivatives III. The formation of isomeric bicyclononanediones IIIe and IIIh and chromanones VIIIa and VIIIb in the reaction of enamines derived from substituted cyclohexanones suggests that the cyclization might proceed also by another pathway than via [3,3] sigmatropic rearrangement. Based

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29

Rybka, Sabina, Jolanta Obniska, Anna Rapacz, Anna Furgała, Barbara Filipek, and Paweł Żmudzki. "Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from 3-(1-phenylethyl)- and 3-benzyl-pyrrolidine-2,5-dione." Bioorganic & Medicinal Chemistry Letters 26, no. 9 (2016): 2147–51. http://dx.doi.org/10.1016/j.bmcl.2016.03.075.

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30

Yurttaş, Leyla, Merve Ertaş, Meral Yılmaz Cankılıç, and Şeref Demirayak. "Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1h- indol- 2, 3- diones." ACTA Pharmaceutica Sciencia 55, no. 1 (2017): 51. http://dx.doi.org/10.23893/1307-2080.aps.0554.

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31

Brown, RFC, KB Caldwell, BM Gatehouse, and PYT Teo. "Synthetic Approaches to Mycorrhizin A and Gilmicolin. III A Synthesis of Tricyclic Enones Epimeric with and Identical with the Key Synthetic Intermediate of Koft and Smith." Australian Journal of Chemistry 38, no. 9 (1985): 1339. http://dx.doi.org/10.1071/ch9851339.

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The cyclopentadiene adduct (2) derived from the benzofuranol (1) undergoes selective deprotonation with lithium diisopropylamide at C 8a, leading with allyl bromide to the 8a-allyl derivative (3) and with Me3SiCl to the silyl ether (8). Reduction and methanolysis of (8) gives the epimeric hydroxy ketones (9) and (10) which by pyrolysis and O-silylation can be converted into the epimeric triethylsilyloxy tricyclic enones (13) and (15); the latter enone is identical with the key synthetic intermediate of Koft and Smith, but is the minor product. Attempted Mitsunobu inversion of the hydroxy enone

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Banfield, JE, GD Fallon, and BM Gatehouse. "Heterocyclic-Derivatives of Guanidine. VI. Formation and X-Ray Structure Determination of 2-Dimethylamino-7,8-diphenyl-4,6-dihydropyrrolo[1,2-a]pyrimidine-4,6-dione." Australian Journal of Chemistry 40, no. 5 (1987): 1003. http://dx.doi.org/10.1071/ch9871003.

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The structure N-(2-dimethylamino-4-oxo-7,8-diphenyl-4,6-dihydropyrrolo [l,2-a]pyrimidi n-6-yl-idene)acetamide (3) is proposed for a compound derived from the action of ketene on 2-(2-imino- 3,4-diphenyl-2H-pyrrol-5-yl)-1,1,3-trimethylguanidine (1; R1 = R2 = R3 = Me) on the basis of the crystal structure of its hydrolysis product, the oxo-compound 2-dimethylamino-7,8-diphenyl-4,6-dihydropyrrolo[l,2-a]pyrimidine-4,6-dione (4), the structure of which was determined by X-ray analysis. A lower homologue of (3), N-(2-methylamino-4-oxo-7,8-diphenyl-4,6-dihydro- pyrrolo[l,2-a]pyrimidin-6-ylidene)aceta

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33

Rybka, Sabina, Jolanta Obniska, Anna Rapacz, Barbara Filipek, and Paweł Żmudzki. "Synthesis and evaluation of anticonvulsant properties of new N -Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs." Bioorganic & Medicinal Chemistry Letters 27, no. 6 (2017): 1412–15. http://dx.doi.org/10.1016/j.bmcl.2017.02.002.

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Hussein, Essam M., Saleh A. Ahmed, Nizar El Guesmi, and Khalid S. Khairou. "1,3-Dipolar cycloaddition approach to novel dispiro[pyrazolidine-4,3′-pyrrolizidine-2′,3″-indoline]-2″,3,5-triones." Journal of Chemical Research 41, no. 6 (2017): 346–51. http://dx.doi.org/10.3184/174751917x14951017434315.

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A simple and convenient 1,3-dipolar cycloaddition of non-stabilised azomethine ylides derived from isatins and L-proline, in a variety of different solvents, to ( Z)-4-arylidene-1-phenylpyrazolidine-3,5-diones as dipolarophiles afforded a series of novel dispiro[pyrazolidine-4,3′-pyrrolizidine-2′,3″-indoline]-2″,3,5-triones regioselectively and in good yields.

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35

Ayudha, Vety Sri Harlinda, and Mokhamat Ariefin. "Synthesis and Characterization of Pyrazine Derived Compounds as Potential Materials for Hole Transporting Layer (HTL)." Jurnal Kimia Sains dan Aplikasi 23, no. 6 (2020): 228–33. http://dx.doi.org/10.14710/jksa.23.6.228-233.

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Three simple compounds that have the potential as a hole transporting layer (HTL) based on pyrazine derivatives conjugated with electron donor groups in the form of triphenylamine have been successfully synthesized and characterized. The synthesis began with a substitution reaction at high temperatures between 4-bromoaniline and 4-iodoanisole to produce 4-bromo-N,N-bis(methoxyphenyl)-aniline, followed by substitution of bromo atoms with tributylstanum at low temperatures and inert atmosphere (N2) producing 4-methoxy-N-(4-(tributylstanyl)phenyl)aniline. The conjugation reaction was carried out

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36

Mehani ne’e Chopra, Rimpi. "ANTI- FUNGAL PROPERTIES OF SYNTHESIZED COMPLEXES OF TRIVALENT TRANSITION METAL IONS DERIVED FROM INDAN-1, 3-DIONE AND DIAMINOBENZENE." Rasayan Journal of Chemistry 11, no. 2 (2018): 694–701. http://dx.doi.org/10.31788/rjc.2018.1121953.

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37

Rybka, Sabina, Jolanta Obniska, Anna Rapacz, Barbara Filipek, and Krzysztof Kamiński. "Synthesis, Physicochemical, and Anticonvulsant Properties of NewN-Mannich Bases Derived from Pyrrolidine-2,5-dione and Its 3-Methyl Analog." Archiv der Pharmazie 347, no. 10 (2014): 768–76. http://dx.doi.org/10.1002/ardp.201400152.

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38

Liao, Hai-Xia, Tai-Ming Shao, Rong-Qing Mei, et al. "Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus Daldinia eschscholtzii HJ004." Marine Drugs 17, no. 12 (2019): 710. http://dx.doi.org/10.3390/md17120710.

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Two new polyketides, 8-O-methylnodulisporin F (1) and nodulisporin H (2), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone (3) and 5-hydroxy-2-methoxynaphtho[9–c]furan-1,4-dione (4), and a new naphthofuran 1,3,8-trimethoxynaphtho[9–c]furan (5), along with five known compounds 4-O-methyl eleutherol (6), 2-acetyl-7-methoxybenzofuran (7), (-)-orthosporin (8), diaporthin (9), and 6-hydroxymellein (10), were obtained from the EtOAc extract of the mangrove-derived fungus Daldinia eschscholtzii HJ004. The structures of the isolated compounds were elucidated by extensive NM

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Pulina, N. A., A. S. Kuznetsov, N. Yu Lisovenko, and D. G. Chemadurov. "Diaza-Wittig reaction of 4,5-disubstituted furan-2,3-diones with triphenylphosphazenes derived from 3-R-adamantanoyldiazomethane." Russian Journal of Organic Chemistry 50, no. 12 (2014): 1783–86. http://dx.doi.org/10.1134/s1070428014120124.

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Kamiński, Krzysztof, Jolanta Obniska, Iwona Chlebek, Beata Wiklik, and Sabina Rzepka. "Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones." Bioorganic & Medicinal Chemistry 21, no. 21 (2013): 6821–30. http://dx.doi.org/10.1016/j.bmc.2013.07.029.

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41

Rodopoulos, Theo, Koji Ishihara, Mary Rodopoulos, M. J. Zaworotko, M. Maeder, and A. McAuley. "Synthesis and reactivity of the macrobicyclic complexes (1,5,8,12-tetraaza-17-oxabicyclo[10.5.2]nonadecane)cobalt(III) perchlorate ([Co(L1)(ClO4)](ClO4)2), [(chloro(1,4,8,11-tetraaza-17-oxabicyclo[9.5.3]nonadecane)cobalt(III) perchlorate ([Co(L2)(Cl)](ClO4)2), (4,8-dimethyl-1,4,8,11-tetraaza-17-oxabicyclo[9.5.3]nonadecane)cobalt(III) perchlorate ([Co(L3)(ClO4)](ClO4)2), and (5,8-dimethyl-1,5,8,12-tetraaza-17-oxabicyclo[10.5.2]nonadecane)cobalt(III) perchlorate ([Co(L4)(ClO4)](ClO4)2) Crystal structure of the L2 complex." Canadian Journal of Chemistry 83, no. 6-7 (2005): 894–902. http://dx.doi.org/10.1139/v05-089.

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The potentially penta-coordinating ligands L2 and L3 have been synthesized by reaction of the 10-membered macrocycle 1,5-diaza-8-oxacyclodecane with either 1,9-dichloro-3,7-diazanonane-2,8-dione, and subsequent reduction of the diamide (3), or with 1,9-dichloro-3,7-(dimethyl)diazanonane-2,8-dione and reduction (L3). A similar procedure is outlined for the dimethylated macrobicycle (L4), based on the corresponding nine-membered 1,4-diaza-7-oxacyclononane. The Co(III) complexes of these ligands and of 1,5,8,12-tetraaza-17-oxabicyclo[10.5.2]nonadecane (L1) have been prepared. Spectrophotometric d

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42

Zhou, Jing, Hairong Zhang, Jing Ye, et al. "Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144." Marine Drugs 19, no. 4 (2021): 186. http://dx.doi.org/10.3390/md19040186.

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Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (3), 8-hydroxy-3-methylxanthone-1-carboxylate (4), crosphaeropsone C (5), and 4-megastigmen-3,9-dione (6). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionization mass spectra (HRESIMS) data. The absolute co

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43

Avdović, Edina H., Danijela Lj Stojković, Verica V. Jevtić, et al. "Preparation and antimicrobial activity of a new palladium(II) complexes with a coumarin-derived ligands. Crystal structures of the 3-(1-(o-toluidino)ethylidene)-chroman-2,4-dione and 3-(1-(m-toluidino) ethylidene)-chroman-2,4-dione." Inorganica Chimica Acta 484 (January 2019): 52–59. http://dx.doi.org/10.1016/j.ica.2018.09.014.

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44

Ito, Chihiro, Tomiyasu Murata, Midori Kato, et al. "Severibuxine, Isolated from Severinia buxifolia, Induces Apoptosis in HL-60 Leukemia Cells." Natural Product Communications 8, no. 6 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800623.

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In an ongoing search for cancer-preventing compounds derived from plant sources, we isolated the quinolin-2,4-dione alkaloid severibuxine from the root bark of Severinia buxifolia collected in Taiwan and then examined the apoptotic effect of this compound. Severibuxine showed cytotoxicity to leukemia HL-60 cells (IC50 = 12.3±0.6 μM). Fluorescence microscopic analysis of cells stained with Hoechst 33342 indicated that the percentage of apoptotic cells showing nuclear condensation and fragmentation increased in a time-dependent manner. In addition, the activities of caspase-9 and caspase-3 were

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45

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds Derived from 2-Mercapto Benzoxazole." Baghdad Science Journal 10, no. 3 (2013): 766–78. http://dx.doi.org/10.21123/bsj.10.3.766-778.

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New series of 2-mecapto benzoxazole derivatives (1-20) incorporated into fused to different nitrogen and suphur containing heterocyclic were prepared from 2-meracpto benzoxazole, when treated with hydrazine hydrate to afford 2-hydrazino benzoxazol (1). Compound (1) converted to a variety of pyridazinone andphthalazinone derivatives (2-4) by reaction with different carboxylic anhydride. Also, reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-phenyl-1,3-thiazolidin-2,4-dione-2-(benzoxazole-2-yl-hydrazone) (6). Azomethines (7-10) were prepared through reaction of (1)

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Hřebabecký, Hubert, Martin Dračínský, Armando M. De Palma, Johan Neyts, and Antonín Holý. "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol." Collection of Czechoslovak Chemical Communications 74, no. 3 (2009): 487–502. http://dx.doi.org/10.1135/cccc2008204.

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Hydroboration of [(1R*,2R*,4R*)-7-oxabicyclo[2.2.1]hept-5-en-2-yl]methyl benzoate (5), which was prepared by Diels–Alder reaction of furan with acrolein and subsequent reduction and benzoylation of the Diels–Alder product, afforded [(1R*,2S*,4S*,6S*)-6-hydroxy-7-oxabicyclo[2.2.1]heptan-2-yl]methyl benzoate (6) and [(1R*,2R*,4R*,5S*)-5-hydroxy-7-oxabicyclo[2.2.1]heptan-2-yl]methyl benzoate (7). The key intermediates, [(1R*,2S*,4S*,6R*)-6-hydroxy-7-oxabicyclo[2.2.1]heptan-2-yl]methyl benzoate (10) and [(1R*,2R*,4R*,5R*)-5-hydroxy-7-oxabicyclo[2.2.1]heptan-2-yl]methyl benzoate (11), were prepared

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47

Hodgson, David M., Rebecca Glen, and Alison J. Redgrave. "[3+2] Cycloaddition reactions of arylacetylenes with carbonyl ylides derived from 1-aryl-1-diazohexane-2,5-diones." Tetrahedron Letters 43, no. 21 (2002): 3927–30. http://dx.doi.org/10.1016/s0040-4039(02)00630-5.

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48

Obniska, Jolanta, Maciej Kopytko, Agnieszka Zagórska, Iwona Chlebek, and Krzysztof Kamiński. "Synthesis and Anticonvulsant Properties of New Mannich Bases Derived from 3-Aryl-pyrrolidine-2,5-diones. Part 1." Archiv der Pharmazie 343, no. 6 (2010): 333–41. http://dx.doi.org/10.1002/ardp.200900250.

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Feng, Joseph C., Cecilia C. Feng, and S. S. Sidhu. "Determination of hexazinone residue and its release from a granular formulation under forest conditions." Canadian Journal of Forest Research 19, no. 3 (1989): 378–81. http://dx.doi.org/10.1139/x89-057.

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The release rate of hexazinone (3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione) applied as a surface coating on a new granular formulation, Pronone 10G, was determined by means of gas chromatography. The area under study was a 3-year-old forest cutover. The exposed granules were retrieved from the field 1, 2, 3, 4, 7, 8, 13, 18, 34, and 37 days after field application. Percent release of hexazinone was 26, 31, 36, 44, 91, 98, 99, 99, 100, and 100%, respectively, at 0.25, 0.25, 0.25, 0.51, 11.7, 11.9, 12.2, 26.2, 104, and 106 mm of cumulative rainfall. Multiple regressi

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Obniska, Jolanta, Iwona Chlebek, Krzysztof Kamiński, and Janina Karolak-Wojciechowska. "Synthesis and Anticonvulsant Properties of NewN-Mannich Bases Derived from 3,3-Diphenyl- and 3-Ethyl-3-methyl-pyrrolidine-2,5-diones. Part III." Archiv der Pharmazie 346, no. 1 (2012): 71–82. http://dx.doi.org/10.1002/ardp.201200265.

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