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Journal articles on the topic '341/34.096 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Friedman, Julia, Kathryn Vannatta, William A. Cunningham, Elisabeth A. Wilde, Keith Owen Yates, and Kristen R. Hoskinson. "34 Severity of Traumatic Brain Injury Predicts Neurobehavioral Outcomes and White Matter Microstructure." Journal of the International Neuropsychological Society 29, s1 (2023): 142–43. http://dx.doi.org/10.1017/s1355617723002382.

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Objective:Pediatric traumatic brain injury (TBI) is the leading cause of disability in children under the age of 15, often resulting in executive function deficits and poor behavioral outcomes. Damage to white matter tracts may be a driving force behind these difficulties. We examined if whether 1) greater TBI severity was associated with worse neurobehavioral outcome, 2) greater TBI severity was associated with tract-based white matter microstructure, and 3) worse neurobehavioral outcome was associated with white matter microstructure.Participants and Methods:Twelve children with complicated-

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Higashionna, Takuya, Ryoichiro Iwanaga, Akiko Tokunaga, et al. "Relationship between Motor Coordination, Cognitive Abilities, and Academic Achievement in Japanese Children with Neurodevelopmental Disorders." Hong Kong Journal of Occupational Therapy 30, no. 1 (2017): 49–55. http://dx.doi.org/10.1016/j.hkjot.2017.10.002.

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Background/Objective Motor coordination impairment is common in children with neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (AD/HD). The purpose of this study was to investigate the relationship between motor coordination, cognitive ability, and academic achievement in Japanese children with neurodevelopmental disorders. Methods Thirty-four school-age (6–12 years old) children with neurodevelopmental disorders and 34 age-matched typically developing (TD) children were recruited in this study. Correlations between the scores of

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Sorokin, M., N. Lutova, and V. Wied. "Phenomenology of psychiatric stigma: A factor of patients’ motivation to treatment." European Psychiatry 64, S1 (2021): S502. http://dx.doi.org/10.1192/j.eurpsy.2021.1344.

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IntroductionPsychiatric patients often are self-stigmatized and hardly involve in the treatment.ObjectivesAssociations of self-stigmatizing beliefs in psychiatric inpatients and their treatment motivation.Methods63 inpatients; ICD-10: F2–65%, F3–13%, F4+F6–14%, F06–8%; mean age 34±13, illness duration 12±11 years. Treatment Motivation Assessment Questionnaire (TMAQ), Internalized Stigma of Mental Illness scale (ISMI); K-mean cluster analysis; dispersion analyses; p≤0.05.Results18 patients of cluster 1 (C1) demonstrated explicit self-stigmatization. In comparison with 25 subjects from cluster 3

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Calderón-Goercke, M., J. J. Gaitán-Valdizán, R. Fernández-Ramón, L. Sánchez-Bilbao, R. Demetrio-Pablo, and R. Blanco. "SAT0512 OCULAR INVOLVEMENT AND TREATMENT IN SARCOIDOSIS. STUDY OF 41 PATIENTS OF A SERIES OF 383 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1212.2–1212. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3757.

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Background:The eye is a common and potential severe complication of sarcoidosis. Topical and systemic corticosteroids are the first-line treatment. Conventional and biological immunosuppressants (IS) are frequently needed(1-5).Objectives:To assess the frequency, clinical and treatment of ocular involvement of sarcoidosis.Methods:Study of a large cohort (n=383) of systemic sarcoidosis from a single university hospital. All consecutive patients diagnosed with sarcoidosis from January 1,1999 to January 1,2019 according the ATS/ERS/WASOG criteria(Eur Respir J 1999;14:735–737) were included.Results

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Abu-Khalaf, Maysa, Fnu Nikita, Ayako Shimada, et al. "Abstract P4-11-32: Change in body mass index in breast cancer survivors." Cancer Research 82, no. 4_Supplement (2022): P4–11–32—P4–11–32. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-11-32.

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Abstract Background: Obesity is associated with an increased risk of breast cancer recurrence and poor survival. Obesity rate in adults in the city of Philadelphia is high, with non-Hispanic blacks and Hispanics having the highest rates. We sought to evaluate changes in body mass index (BMI) in breast cancer survivors within the first 2 years from initial encounter for a breast cancer (BC) diagnosis (dx), and investigate factors that may correlate with a change in BMI. Methods: We identified 5,423 BC patients (pts) in our electronic medical record, (1/2015-present), using ICD-10 code C50.X. We

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Hill, Timothy A., Jennette A. Sakoff, Phillip J. Robinson, and Adam McCluskey. "Parallel Solution-Phase Synthesis of Targeted Tyrphostin Libraries with Anticancer Activity." Australian Journal of Chemistry 58, no. 2 (2005): 94. http://dx.doi.org/10.1071/ch04143.

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The combination of semi-automation, an elegant synthesis, and parallel solution-phase synthesis approaches has allowed the development of five targeted, symmetrical tyrphostin compound libraries. These libraries on average are comprised of 12 compounds. Notwithstanding this, low micromolar potent growth inhibitors against HT29 (colorectal carcinoma) and G401 (renal carcinoma) cell lines were discovered. Additionally, significant SAR data was obtained. We noted that the most potent growth inhibitory activity was consistently observed for those analogues that possessed a 2-chlorophenyl (for 10:

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Shipovskaya, A. A., I. V. Kurbatova та O. P. Dudanova. "Pleiotropic eﬀects of ursodeoxycholic acid in patients with non-alcoholic steatohepatitis with impaired glycemic control". Experimental and Clinical Gastroenterology 183, № 11 (2020): 34–38. http://dx.doi.org/10.31146/1682-8658-ecg-183-11-34-38.

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The goal was to determine the eﬀect of ursodeoxycholic acid (UDCA) in non-alcoholic steatohepatitis (NASH) with impaired glycemic control.Materials and methods. 67 patients NASH were examined: prediabetes — 38 (56.7%), type 2 diabetes mellitus 29 (43.3%), men — 39 (58.2%), women — 28 (41.8%), age — 45.1 ± 10.2 years. The UDCA dose was 9.4 ± 2.0 mg / kg / day during 59.7 ± 77.6 weeks. Fragments of cytokeratin-18 (FCK-18) (TPS ELISA, Biotech, Sweden), TNF-α (Human TNFα Platinum ELISA, eBioscience, Austria), IL-6 (“Interleukin-6-IFA-Best”, Vector-Best, Russia), insulin (“Insulin TEST System”, Mon

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Kitko, Carrie L., Rima M. Saliba, Sophie Paczesny, et al. "Risk Factors for Non-Relapse Mortality in Chronic Graft Versus Host Disease: Predicting Outcomes At Disease Onset." Blood 120, no. 21 (2012): 1941. http://dx.doi.org/10.1182/blood.v120.21.1941.1941.

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Abstract Abstract 1941 Chronic graft versus host disease (cGVHD) is a major contributor to morbidity and mortality in long-term survivors of allogeneic hematopoietic cell transplantation (HCT). The treatment course is heterogeneous and unpredictable, and a prognostic system at the time of disease onset is highly desirable. Current systems were not developed for disease onset (Arai, Blood, 2011), or used the limited/extensive classification (Arora, Blood, 2011). In addition, utilization of these systems is time consuming, complex, and practice variation can lead to inconsistent application. We

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Maytal, Joseph, and Shlomo Shinnar. "Febrile Status Epilepticus." Pediatrics 86, no. 4 (1990): 611–16. http://dx.doi.org/10.1542/peds.86.4.611.

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As part of a study of status epilepticus in children (Maytal J, Shinnar S, Moshe SL, Alvarez LA. Pediatrics. 1989;83:323-331); 44 children with febrile convulsions lasting more than 30 minutes were followed for a mean of 28 months (range 4 to 72). Thirty children were followed prospectively. Children with prior afebrile seizures or evidence of acute central nervous system infection were excluded. Nine (20%) children had prior neurological deficits. The duration of the febrile seizure was 0.5 to 1 hour in 41 cases (85%), 1 to 2 hours in 5 (10%), and greater than 2 hours in 2 children (5%). No c

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Koscielny, J., J. T. Tauer, B. Huhn, et al. "Desmopressin testing in haemo-philia A patients and carriers." Hämostaseologie 32, no. 04 (2012): 271–75. http://dx.doi.org/10.5482/hamo-12-06-0012.

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SummaryIntroduction: Desmopressin (DDAVP) testing (DT) in patients (pts) with haemophilia A (HA) and carriers (CHA) is up to now not standardized. This prompted us to evaluate results of DT carried out between 1996 and 2011 in centres of the Competence Network Haemor-rhagic Diatheses East. Patients and method: An increase of the factor VIII activity (FVIII) above 50% or at least the two fold of initial values within 120 min after DDAVP was defined as complete response (CR). Data from 80 patients (31 children, 49 adults) of whom 64 suffered from HA (sub-HA: n = 48; mild: n = 14; moderate: n = 2

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Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis

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De Hooge, M., A. Ishchenko, S. Steinfeld, et al. "OP0055 MINIMAL RADIOGRAPHIC DAMAGE OF SACROILIAC JOINTS DETECTED IN PSORIATIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 37.1–37. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2392.

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Background:Psoriatic arthritis (PsA) is an inflammatory joint disease that is traditionally included in the Spondyloarthritis (SpA) spectrum. Prevalence and impact of axial involvement in PsA remains understudied but increasingly affects treatment decisions.Objectives:The first step, in this multi-purpose radiographic study, is to report on baseline radiographic damage of the sacroiliac joints (SIJ) in PsA patients from a prospective multicentre cohort study in private and academic rheumatology practices.Methods:Data from the Belgian Epidemiological Psoriatic Arthritis Study (BEPAS), a prospec

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Gerasimova, E., T. Popkova, A. Aleksankin, and D. Tabakov. "POS0622 THE BLOOD T-CELL SUBSETS IN RHEUMATOID ARTHRITIS PATIENTS ON LONG-TERM IL-6 RECEPTOR BLOCKER THERAPY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 549.1–549. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2310.

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Background:Pleiotropic effects of IL-6 receptor antagonist tocilizumab (TCZ) in rheumatoid arthritis (RA) involve circulating T-cells. Preliminary reports have suggested that TCZ therapy can modulate T cell function and humoral immune responses in RA [1,2]. According to other studies, TCZ had no influence on T-lymphocyte subdifferentiation [3].Objectives:To assess the effect of 12 months (m) TCZ therapy on T-cell phenotype, and to analyze the association between T-cell subsets and RA activity.Methods:36 active RA pts (29F/7M); median age 55[46; 64] years; disease duration 120[72; 1928]m; DAS28

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Xiang, L., A. Low, Y. Y. Leung, et al. "POS1413 INTERVAL BETWEEN SYMPTOM ONSET AND DIAGNOSIS AMONG PATIENTS WITH AUTOIMMUNE RHEUMATIC DISEASES IN A MULTI-ETHNIC ASIAN POPULATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 990.1–990. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1713.

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Background:The interval between symptom onset and diagnosis can often be longer than is ideal in autoimmune rheumatic diseases (ARDs).Objectives:We aimed to characterise this interval among patients newly diagnosed with ARDs in a multi-ethnic Asian population and to identify factors associated with a longer interval.Methods:We used Scott’s model of pathways to treatment to characterise the interval between symptom onset and diagnosis into 4 intervals: #1 between symptom onset and first seeking medical attention, #2 between first medical attention and rheumatology referral, #3 between rheumatol

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Łosińska, K., M. Wilk, A. H. Pripp, M. Korkosz, and G. Haugeberg. "AB0219 EXPLORING LONG-TERM DRUG EFFECTIVENESS AND DRUG SURVIVAL FOR RITUXIMAB REFERENCE DRUG IN TREATMENT OF RHEUMATOID ARTHRITIS PATIENTS IN ORDINARY OUTPATIENT CLINIC." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1135.3–1136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1661.

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Background:In randomized controlled trials (RCTs) rituximab (RTX) has been shown to effectively suppress inflammation and reduce structural joint damage in rheumatoid arthritis (RA) patients [1]. There is a lack of RA data on RTX effectiveness and drug survival when used in real life practice.Objectives:To explore long-term drug effectiveness and drug survival for RTX used to treat RA patients in ordinary clinical practice.Methods:The study population included RA patients treated between 2006 and 2020 with RTX at an outpatient clinic in Norway. Patients were monitored using recommended measure

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Ransohoff, Julia D., Karen Andrade, Natasha Purington, et al. "Abstract P3-12-34: Antibiotic use and mortality from triple-negative breast cancer." Cancer Research 82, no. 4_Supplement (2022): P3–12–34—P3–12–34. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-12-34.

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Abstract Background: Gut-associated lymphoid tissue is the largest component of the body's immune system, as it influences both local and systemic immune responses. Gut microbiome dysbiosis related to antimicrobial exposure may be associated with decreased circulating and tumor-infiltrating lymphocytes and decreased immune repertoire, which may adversely impact survival in patients with triple-negative breast cancer (TNBC). We hypothesized that increasing antimicrobial exposure may lead to higher overall mortality (OM) and BC-specific mortality (BCM) in the presence of time-varying absolute ly

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Ayan, G., A. Sadic, L. Kiliç, and U. Kalyoncu. "AB0946 Pelvis radiography findings and progression rates in patients with Psoriatic Arthritis under biologic treatment." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1601.2–1602. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3471.

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BackgroundPsoriatic arthritis (PsA) is a heterogenous disease that can present with various musculokeletal manifestations. Several studies have assessed the rate of sacroileitis in PsA population, however data on the involvement of other pelvic structures that may cause symptoms, such as major entheseal or hip involvevement, and progression rates during follow-up is scarce.ObjectivesThis study aimed to understand overall pelvis radiography findings and progression rates during follow-up in a cohort of patients with PsA under biologic treatment.MethodsPsA patients from the Hacettepe University

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Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Kibirige, Davis, Isaac Sekitoleko, William Lumu, et al. "Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes." Diabetologia 65, no. 4 (2022): 675–83. http://dx.doi.org/10.1007/s00125-021-05644-8.

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Abstract Aims/hypothesis Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This cross-sectional study aimed to perform a detailed clinical and metabolic characterisation of newly diagnosed adult patients with diabetes in Uganda, in order to compare features between lean and non-lean individuals. Methods Socio-demographic, clinical, biophysical and metabolic (including oral glucose toleranc

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Prutchi-Sagiv, Sara, Nataliya Golishevski, Odelia Katz, et al. "T-Cell Abnormalities in Patients with Myelodysplastic Syndromes: Improved Immunological Functions in Patients Treated with Recombinant Erythropoietin." Blood 108, no. 11 (2006): 2675. http://dx.doi.org/10.1182/blood.v108.11.2675.2675.

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Abstract Erythropoietin (Epo) is being used to treat anemias. We have observed prolonged survival in patients with multiple myeloma (MM) on recombinant Epo (rHuEpo) (Mittelman, EJH 2004). Studies on mice suggested an Epo anti-MM immune effect (Mittelman, PNAS 2001; Katz, Acta Haem 2005), and we have also found improved immunity in rHuEpo-treated MM patients. Here we tested the effect of Epo on immune function in myelodysplastic syndrome (MDS). We tested 27 MDS patients (15 controls). We show immune defects in early (IPSS low/int1) MDS, that are more pronounced in progressive disease. Consisten

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Dauvilliers, Yves, Abby Chen, Marisa Whalen, Wayne Macfadden, and Michael Thorpy. "0592 Efficacy of Lower-Sodium Oxybate by Baseline Sleep Inertia in a Phase 3 Clinical Study in Patients With Idiopathic Hypersomnia." SLEEP 46, Supplement_1 (2023): A260. http://dx.doi.org/10.1093/sleep/zsad077.0592.

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Abstract Introduction Idiopathic hypersomnia is a debilitating neurologic sleep disorder. Sleep inertia (difficulty awakening) is a common symptom that can significantly impair functioning and quality of life. This post hoc analysis evaluated response to lower-sodium oxybate (LXB; Xywav®) by baseline sleep inertia in a phase 3 trial (NCT03533114). Methods Eligible participants began LXB treatment with an open-label treatment titration and optimization period (10–14 weeks), followed by a 2-week stable-dose period (SDP). Participants were randomized to placebo or continued LXB treatment during a

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Chukanov, Nikita V., Sergey M. Aksenov, Ramiza K. Rastsvetaeva, et al. "Eleonorite, Fe63+(PO4)4O(OH)4·6H2O: validation as a mineral species and new data." Mineralogical Magazine 81, no. 1 (2017): 61–76. http://dx.doi.org/10.1180/minmag.2016.080.070.

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AbstractEleonorite, ideally Fe63+(PO4)4O(OH)4·6H2O, the analogue of beraunite Fe2+Fe53+(PO4)4O(OH)5·6H2O with Fe2+ completely substituted by Fe3+, has been approved by the International Mineralogical Association Commission on New Minerals, Nomenclature and Classification as a mineral species (IMA 2015-003). The mineral was first described on material from the Eleonore Iron mine, Dünsberg, near Giessen, Hesse, Germany, but during this study further samples were required and a neotype locality is the Rotläufchen mine, Waldgirmes, Wetzlar, Hesse, Germany, where eleonorite is associated with goeth

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Manafov, Parvin Galib oglu. "THE CLINIC-ANAMNESTIC FEATURES OF PSORIASIS AT ADULT PERSONS IN BAKU." Siberian Journal of Life Sciences and Agriculture 16, no. 2 (2024): 377–87. http://dx.doi.org/10.12731/2658-6649-2024-16-2-1078.

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Background. Currently, psoriasis is one of the most common chronic dermatoses, which affects 1 to 3% of the world's population. Purpose. The purpose of this study is to study the epidemiological features of the spread of psoriasis and to give a microbiological characteristic of the causative agents of psoriasis among men in Baku. Material and methods of study. In the context of the purpose and objectives of the study, 490 men admitted to the Republican Dermatovenerologic Dispensary in 2018-2019. were examined for Psoriasis (in 2018 - 225 people (45.9%), in 2019 - 265 people (54.1%)). The mean

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Vitovskiy, R., O. Bolshak, V. Boukarim, Yu Bakhovska, and V. Popov. "Mitral Valve Plasty During Correction of Combined Mitral-Aortic Valve Diseases." Ukrainian journal of cardiovascular surgery, no. 4 (41) (December 16, 2020): 63–68. http://dx.doi.org/10.30702/ujcvs/20.4112/059063-068/407-08-097.

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The aim. To study reconstructive operations on the mitral valve (MV) combined with aortic valve replacement (AVR) for combined mitral-aortic valve defects (CMAVD). Materials and methods. The study included 1690 patients with CMAVD who underwent surgical treatment at the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine for the period from 01/01/2006 to 01/01/2020. Of these, 429 (23.4%) patients underwent MV reconstruction with AVR. The following valve-sparing procedures were performed: – application of annuloplasty ring: 123

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Bengtsson, K., J. Askling, M. Lorentzon, et al. "POS0959 RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN ANKYLOSING SPONDYLITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 785.2–786. http://dx.doi.org/10.1136/annrheumdis-2022-eular.509.

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BackgroundOsteoporosis is common in patients with ankylosing spondylitis (AS) and a risk factor for fragility fractures. Additional established risk factors for fractures in the general population include higher age, female sex, previous fracture, fall tendency, glucocorticoid treatment, insulin dependent diabetes, smoking and high alcohol consumption.ObjectivesTo estimate the influence of established risk factors for fragility fractures on the development of non-vertebral fractures in AS and population controls.MethodsThrough linkage of national population and health care registers 2001-2016,

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van der Merwe, Maria-Terésa, Per-Anders Jansson, Nigel J. Crowther, et al. "Lactate and Glycerol Release from Subcutaneous Adipose Tissue in Black and White Lean Men1." Journal of Clinical Endocrinology & Metabolism 84, no. 8 (1999): 2888–95. http://dx.doi.org/10.1210/jcem.84.8.5927.

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To measure interstitial glycerol and lactate production from the sc adipose tissue of two regions in nine black and nine white lean men, sc microdialysis was performed in combination with adipose tissue blood flow rates measured with 133Xe clearance. In the postabsorptive state, the plasma glucose and insulin levels of the black men and white men were similar. The black men had higher plasma free fatty acids (825 ± 97 vs. 439 ± 58 μmol/L; P &lt; 0.005), glycerol (99.5 ± 5.1 vs. 54.1 ± 3.3 μmol/L; P&lt; 0.0001), and lactate (1056 ± 95 vs. 729 ± 45 μmol/L; P &lt; 0.01). Interstitial

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Wong, Rachel Su Jen, Jiaxuan Wu, Alisha Joan Leen, et al. "The role of targeted therapy (TKI) in the treatment of advanced hepatocellular carcinoma (aHCC) in the era of immunotherapy: Real-world data using AI analytics from an academic medical center." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16623-e16623. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16623.

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e16623 Background: The management of aHCC has evolved dramatically in recent years, with new agents like immunotherapy receiving regulatory approval. As we begin incorporating these drugs into routine clinical practice, data on real-world sequencing of therapies and clinical outcomes are needed. Methods: We utilised the DISCOVERYAI platform, a virtual machine containing de-identified patient electronic health records to review HCC patients treated at the National University Health System, Singapore from January 2015 to December 2019. We then identified those who received systemic therapy and c

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Al-Kaisey, Ahmed M., Ramanathan Parameswaran, Christina Bryant, et al. "Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress." JAMA 330, no. 10 (2023): 925. http://dx.doi.org/10.1001/jama.2023.14685.

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ImportanceThe impact of atrial fibrillation (AF) catheter ablation on mental health outcomes is not well understood.ObjectiveTo determine whether AF catheter ablation is associated with greater improvements in markers of psychological distress compared with medical therapy alone.Design, Setting, and ParticipantsThe Randomized Evaluation of the Impact of Catheter Ablation on Psychological Distress in Atrial Fibrillation (REMEDIAL) study was a randomized trial of symptomatic participants conducted in 2 AF centers in Australia between June 2018 and March 2021.InterventionsParticipants were random

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POLATOWSKA, Marika, Zuzanna CZUDY, Hanna DOMINIK, et al. "When diet is not enough - obesity treatment options." Journal of Education, Health and Sport 42, no. 1 (2023): 24–34. https://doi.org/10.12775/JEHS.2023.42.01.002.

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<strong>POLATOWSKA, Marika, CZUDY, Zuzanna, DOMINIK, Hanna, PAWĘSKA, Wojciech, RADWAŃSKI, Jan, GADOMSKA, Anna, KUREK, Justyna, GORZYŃSKI, Rafał, GARSTKA, Michał & MOLCZYK-SIEŃCZAK, Justyna. When diet is not enough - obesity treatment options</strong><strong>. </strong><strong>Journal of Education, Health and Sport. 2023;42(1):</strong><strong>24</strong><strong>-</strong><strong>34</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.42.01.00</strong><strong>2</strong> <strong>https://apcz.umk.pl/JEHS/article/view/44</strong><strong>112</strong> <str

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Mease, P. J., A. Setty, K. Papp, et al. "POS1539 SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH PSORIATIC ARTHRITIS AND INADEQUATE RESPONSE TO BIOLOGICS: 3-YEAR RESULTS FROM THE PHASE 3 SELECT-PSA 2 STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1136–37. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2513.

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BackgroundThe efficacy and safety of upadacitinib (UPA) in patients (pts) with psoriatic arthritis (PsA) and inadequate response to ≥1 biologic disease-modifying antirheumatic drug (bDMARD-IR) have been demonstrated up to 56 and 104 weeks of treatment[1,2].ObjectivesTo assess the long-term safety and efficacy of UPA in bDMARD-IR pts with PsA through 152 weeks of treatment in the SELECT-PsA 2 study.MethodsPts were randomized to receive UPA 15 or 30 mg once daily (QD), or placebo (PBO) for 24 weeks, followed by blinded switch to UPA 15 or 30 mg QD for pts initially randomized to PBO. After 56 we

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Pavlu, Jiri, Katayoun Rezvani, Bhuvan Kishore, et al. "Elevated Preconditioning Serum Levels of C-Reactive Protein Are Associated with Increased Nonrelapse Mortality and Inferior Survival After Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation." Blood 118, no. 21 (2011): 1945. http://dx.doi.org/10.1182/blood.v118.21.1945.1945.

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Abstract Abstract 1945 Introduction: Identification of prognostic indicators which predict outcome of allogeneic stem cell transplantation (allo-SCT) is important for selection of patients who may benefit from the procedure. The European Group for Blood and Marrow Transplantation (EBMT) proposed a scoring system for CML which, after modification, also predicted outcomes for patients transplanted for other hematologic malignancies. We have recently shown that the level of C-reactive protein (CRP) measured shortly before transplantation is another important prognostic factor in patients undergoi

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Habib, Alma, Nausheen Ahmed, Abdullah Mohammad Khan, et al. "A Real-World Analysis of the Safety and Efficacy of BCMA-Directed CAR T-Cell Therapy for Patients with Relapsed/Refractory Multiple Myeloma and Baseline Renal Impairment." Blood 144, Supplement 1 (2024): 2009. https://doi.org/10.1182/blood-2024-208799.

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Introduction: Novel treatments targeting B-cell maturation antigen (BCMA), such as ciltacabtagene autoleucel (cilta-cel) and idecabtagene vicleucel (ide-cel), have shown promising results in treating relapsed or refractory multiple myeloma (RRMM). Despite significant clinical improvements in patients, there is limited real-world evidence on outcomes and toxicities in patients with baseline renal impairment (RI) receiving BCMA chimeric antigen receptor T-cell therapy (CART). Methods: This multicenter, retrospective study includedRRMM patients who received either cilta-cel or ide-cel at multiple

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Canonaco, Francesco, Anna Tobler, Gang Chen, et al. "A new method for long-term source apportionment with time-dependent factor profiles and uncertainty assessment using SoFi Pro: application to 1 year of organic aerosol data." Atmospheric Measurement Techniques 14, no. 2 (2021): 923–43. http://dx.doi.org/10.5194/amt-14-923-2021.

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Abstract. A new methodology for performing long-term source apportionment (SA) using positive matrix factorization (PMF) is presented. The method is implemented within the SoFi Pro software package and uses the multilinear engine (ME-2) as a PMF solver. The technique is applied to a 1-year aerosol chemical speciation monitor (ACSM) dataset from downtown Zurich, Switzerland. The measured organic aerosol mass spectra were analyzed by PMF using a small (14 d) and rolling PMF window to account for the temporal evolution of the sources. The rotational ambiguity is explored and the uncertainties of

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Nagler, Arnon, Allain-Thibeault Ferhat, Nicolaus Kröger, et al. "Non-T-Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation from Unrelated and Matched Sibling Donors in Patients with Secondary Acute Myeloid Leukemia in First Complete Remission: A Study from the ALWP/EBMT." Blood 144, Supplement 1 (2024): 505. https://doi.org/10.1182/blood-2024-194057.

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Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapeutic option for secondary acute myeloid leukemia (sAML. Non-T-cell depleted haploidentical stem cell transplantation (HaploSCT) may serve as the preferred therapeutic option (J Hematol Oncol 2023, 16(1):106). Methods: The study aimed to compare outcomes of HaploSCT to those of HSCT from a matched sibling donor (MSD) or matched (9-10/10) unrelated donor (MUD) performed between 2010 and 2022 in patients (pts) with sAML in first complete remission (CR1). Statistical tests included a multivariate analysis (M

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Hoeks, Marlijn, Saskia Langemeijer, Louise De Swart, et al. "Elevated Labile Plasma Iron Levels (LPI) and Increased Oxidative Stress Are Associated with Red Blood Cell Transfusions in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Subtitle: from the European Leukemianet MDS Registry." Blood 128, no. 22 (2016): 4327. http://dx.doi.org/10.1182/blood.v128.22.4327.4327.

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Abstract Background: The EUMDS registry, collecting prospective observational data on lower-risk MDS (LR-MDS) patients from 142 centers in 17 countries, is performing a study on the hypothesized negative impact of red blood cell transfusions (RBCT) on outcome in LR-MDS. The aim of this study istoevaluate in transfusion dependent (TD) patients temporal changes in iron metabolism and presence of potentially toxic forms of iron, measured as labile plasma iron (LPI) and their impact on oxidative stress, using malondialdehyde (MDA), and their impact on survival. Methods: We analyzed serum samples f

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Flouri, I., A. Repa, N. Avgustidis, et al. "AB0375 IN PATIENTS STARTING ETANERCEPT, MALE SEX, ABSENCE OF COMORBIDITIES AND NO csDMARDs CO-ADMINISTRATION ARE INDEPENDENT PREDICTORS OF LONG-TERM (MORE THAN 3 YEARS) PERSISTENCE TO THERAPY, IRRESPECTIVELY OF THE CLINICAL DIAGNOSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1314.2–1315. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4826.

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BackgroundComparative data among rheumatoid arthritis (RA), spondylarthritis (SpA) and psoriatic arthritis (PsA) patients regarding long-term survival of etanercept (ETN) in clinical practice are limited.ObjectivesThe first aim of this study was to analyze the long-term (>3 years) ETN survival comparatively between its three main indications. We also aimed to analyze for predictors of long term ETN survival.MethodsWe analyzed data from the University of Crete Rheumatology Clinic Registry (UCRCR), a single center prospective cohort study. All patients with a diagnosis of RA, SpA or PsA start

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Mehic, Dino, Jasmin Sabrina Rast, Michelle Fuchs, et al. "Utility of the Platelet Function Analyzer (PFA-100) in Patients with Bleeding Disorder of Unknown Cause." Blood 142, Supplement 1 (2023): 3965. http://dx.doi.org/10.1182/blood-2023-185756.

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Introduction: Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion and patients share a similar phenotype with established mild bleeding disorders (MBDs) such as platelet function defects (PFD), mild von Willebrand disease (VWD), or mild coagulation factor deficiencies (CFD). The integration of global assays, such as the Platelet Function Analyzer (PFA)-100, as screening tools for MBDs lacks universal endorsement and is currently not recommended in clinical routine. While the PFA-100 has demonstrated noteworthy sensitivity in the detection of VWD, data regarding its clinical u

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Shah, Gunjan L., Michael Scordo, Satyajit Kosuri, et al. "Comparable Survival and Incidence of Toxicity for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation." Blood 128, no. 22 (2016): 1236. http://dx.doi.org/10.1182/blood.v128.22.1236.1236.

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Abstract Introduction: Systemic evaluation of toxicities after allogeneic hematopoietic stem cell transplantation (allo-HCT) has been limited. Ex vivo CD 34+ selection prior to allo-HCT reduces GVHD without increasing relapse, but is usually done in the context of myeloablative conditioning. Comprehensive collection of toxicities is particularly important in older patients (pts) who usually receive a reduced intensity conditioning. Aim: To identify toxicity patterns in older pts and their association with overall survival (OS) and non-relapse mortality (NRM). Methods: A retrospective analysis

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Trotman, Judith, Katherine Rankin, Ibrahim Tohidi-Esfahani, et al. "Long-Term Impact of Dose Interruptions (DIs) of Bruton Tyrosine Kinase Inhibitors (BTKis) on Change in IgM Levels and Clinical Outcomes in Waldenström Macroglobulinemia (WM)." Blood 144, Supplement 1 (2024): 4412. https://doi.org/10.1182/blood-2024-200334.

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Introduction: BTKis are a mainstay of therapy for patients with WM, with most receiving continuous oral monotherapy for several years. While dosing is commonly interrupted, data on the impact of BTKi DIs on disease control remain limited. The phase 1/2 BGB-3111-AU-003 study (NCT02343120) evaluated zanubrutinib monotherapy in patients with B-cell malignancies. The subsequent phase 3 ASPEN study (NCT03053440) evaluated zanubrutinib vs ibrutinib in patients with MYD88 mutated WM and zanubrutinib in patients with MYD88 wild-type WM. At the end of each study, eligible patients (including those in t

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Fahey, Margaret C., Marion E. Hare, Gerald W. Talcott, et al. "Characteristics Associated With Participation in a Behavioral Weight Loss Randomized Control Trial in the U.S. Military." Military Medicine 184, no. 3-4 (2018): e120-e126. http://dx.doi.org/10.1093/milmed/usy199.

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Abstract Introduction Effective recruitment and subsequent enrollment of diverse populations is often a challenge in randomized controlled trials, especially those focused on weight loss. In the civilian literature, individuals identified as racial and ethnic minorities, men, and younger and older adults are poorly represented in weight loss interventions. There are limited weight loss trials within military populations, and to our knowledge, none reported participant characteristics associated with enrollment. There may be unique motives and barriers for active duty personnel for enrollment i

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Gladstone, Douglas Edward, Amanda Blackford, Yvette L. Kasamon, et al. "IGHV Mutational Status Is Prognostic in Del(11q) and Del(17p) Chronic Lymphocytic Leukemia." Blood 118, no. 21 (2011): 4598. http://dx.doi.org/10.1182/blood.v118.21.4598.4598.

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Abstract Abstract 4598 Introduction The importance of interphase fluorescence in-situ hybridization (FISH) DNA analysis as a predictive tool for survival in patients with chronic lymphocytic leukemia (CLL) is well-established. However, even among cytogenetically defined groups, survival varies widely. In CLL patients who harbor del(13q), their IGHV mutational status predicts for Rai stage progression, treatment initiation and overall survival. Here we analyze, the influence of IGHV mutational status upon overall survival in CLL patients harboring the poor prognostic CLL FISH findings of a del(

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Gugliotta, Luigi, Carlos Besses, Martin Griesshammer, et al. "Combination of Cytoreductive Therapies in Patients with Essential Thrombocythemia: A Preliminary Report From the E.X.E.L.S. Study." Blood 120, no. 21 (2012): 2842. http://dx.doi.org/10.1182/blood.v120.21.2842.2842.

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Abstract Abstract 2842 Background: As some patients (pts) with essential thrombocythemia (ET) may discontinue their cytoreductive treatment because of drug intolerance/inefficacy, combinations of drugs with different activity/tolerability patterns are being utilized in clinical practice. Objectives: To evaluate the clinical relevance and patterns of cytoreductive combination treatment in ET in Evaluation of Xagrid™ Efficacy and Long-term Safety (EXELS), an observational study in 3643 European pts with high-risk ET. Patients and Methods: Data on pts receiving cytoreductive treatments in combina

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Burkhart, Scott O., Christine Ellis, and Troy M. Smurawa. "ACUTE PERFORMANCE ON A VESTIBULAR AND OCULAR MOTOR SCREENER AND RECOVERY FOLLOWING CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0013. http://dx.doi.org/10.1177/2325967119s00136.

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Background: Concussion injuries are synonymous with vestibular impairments and symptoms include dizziness, impaired balance, and problems with gaze stability (Covassin et al., 2014). Common ocular motor impairments after a concussion include convergence/accommodative insufficiencies and saccadic dysfunction (Mucha et al., 2014). Vestibular and ocular motor impairments have been linked to worse outcomes following concussion (Pearce et al., 2015), including prolonged recovery (Corwin et al., 2015). The purpose of the current study was to determine which VOMS impairments were linked with longer r

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Berenson, James R., Robert Pflugmacher, Peter Jarzem, et al. "Final Results of the First Randomized Trial Comparing Balloon Kyphoplasty (BKP) to Non-Surgical Management Among Cancer Patients with Vertebral Compression Fractures: Marked Improvement in Back Function, Quality of Life and Pain in the BKP Arm." Blood 114, no. 22 (2009): 2873. http://dx.doi.org/10.1182/blood.v114.22.2873.2873.

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Abstract Abstract 2873 Poster Board II-849 Destructive vertebral lesions are a common source of morbidity for patients with cancer. Balloon kyphoplasty (BKP) is a minimally invasive surgical procedure for patients with painful vertebral compression fractures (VCFs) with the goal of reducing pain and disability. We report the final results of the first randomized trial among cancer patients with VCFs to assess the efficacy and safety of BKP. Twenty-two multinational sites enrolled 134 patients after consent and ethical review board approval. Adult patients diagnosed with cancer and ' 3 painful

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Zhang, X., H. Huang, D. Gao, Y. Fan, and Z. Zhang. "OP0283 MYCOPHENOLATE MOFETIL VS CYCLOPHOSPHAMIDE FOR TREATMENT OF LUPUS NEPHRITIS: A SINGLE-CENTER COHORT REAL-WORLD ANALYSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 188.1–188. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2222.

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BackgroundMycophenolate mofetil (MMF) or low-dose intravenous cyclophosphamide (CYC) are recommended as initial (induction) treatment in many recommendations for the management of lupus nephritis (LN), and randomized controlled trials have shown their similar efficacy. However, there is little to no real-world data.ObjectivesWe conducted the real-world analysis to compare the efficacy and safety of MMF and CYC for the induction treatment of LN.MethodsOur patients came from PKUFH SLE cohort, a single-center longitudinal observational cohort set up in 2007, and only patients received initial rem

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Sharp, John, Qiuhong Zhao, Timothy Voorhees, et al. "Acute Kidney Injury Following Chimeric Antigen Receptor T-Cell Therapy Is Associated with Inferior Survival for Patients with Relapsed or Refractory Large B-Cell Lymphoma." Blood 144, Supplement 1 (2024): 3747. https://doi.org/10.1182/blood-2024-203798.

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Background: Chimeric antigen T-cell receptor therapy (CAR-T) has revolutionized treatment of relapsed/refractory (R/R) large B-cell lymphomas (LBCL). Acute kidney injury (AKI) is a notable toxicity of CAR-T that may be associated with inferior outcomes. The etiology of AKI during CAR-T is likely multi-factorial and may include cytokine release syndrome (CRS), intravascular volume depletion, tumor lysis syndrome (TLS), exposure to nephrotoxic agents, and others. A prior study examining AKI in LBCL patients (pts) treated with CAR-T was limited by sample size (n=46) limiting their ability to eval

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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