Relevant bibliographies by topics / 4-Pyridones

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic '4-Pyridones'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "4-Pyridones"

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Sośnicki, Jacek G., and Tomasz J. Idzik. "Pyridones – Powerful Precursors for the Synthesis of Alkaloids, Their Derivatives, and Alkaloid-Inspired Compounds." Synthesis 51, no. 18 (2019): 3369–96. http://dx.doi.org/10.1055/s-0037-1611844.

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2-Pyridone is characterized by a very wide range of reactivity of a different nature, ranging from electrophilic aromatic substitution, CH–metal-mediated reactions, and NH/OH functionalization of both possible lactam/lactim tautomers, through cycloaddition, to nucleophilic addition and transformation of the tautomeric C=O/C–OH moiety. The high availability of 2-pyridones and the possibility of their far-reaching functionalization additionally increased their values. Therefore, they are very useful building blocks for the synthesis of structurally diverse piperidine and pyridine compounds, incl
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Tadic, Julijana, Marina Mihajlovic, Mica Jovanovic, and Dusan Mijin. "Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones." Journal of the Serbian Chemical Society 84, no. 6 (2019): 531–38. http://dx.doi.org/10.2298/jsc180703092t.

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In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2- -pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially
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Steparuk, Elena V., Dmitrii L. Obydennov, and Vyacheslav Y. Sosnovskikh. "Synthesis of 5-Aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones." Molbank 2023, no. 2 (2023): M1668. http://dx.doi.org/10.3390/m1668.

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A two-stage synthesis of 5-aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones (56–66% overall yields) was carried out by refluxing 5-aroyl-3-(benzyloxy)-2-(het)aryl-4H-pyran-4-ones with ammonium acetate in AcOH and subsequent debenzylation. The prepared N-unsubstituted 4-pyridones exist in the pyridone tautomeric form.
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Hayat, Faisal, Manoj Sonavane, Mikhail V. Makarov, et al. "The Biochemical Pathways of Nicotinamide-Derived Pyridones." International Journal of Molecular Sciences 22, no. 3 (2021): 1145. http://dx.doi.org/10.3390/ijms22031145.

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As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its methylated form, and its ribosylated form. While they are viewed as markers of over-oxidation, they are often wrongly reported or mislabeled. To address this, we provide a comprehensive characterization of these catabolites of vitamin B3, justify their nomenclature, and differentiate between the biochemical pathways that lead to their generation. Fur
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Tan, Liquan, Peng Zhou, Cui Chen та Weibing Liu. "An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide". Beilstein Journal of Organic Chemistry 9 (28 листопада 2013): 2681–87. http://dx.doi.org/10.3762/bjoc.9.304.

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A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides. A variety of β-keto amides are used in this approach, and a wide range of functionalized 4-pyridones and 2-pyridones were obtained in good to excellent yields. When employing the N-aryl β-keto amides as the substrates in this protocol, 4-pyridones are resulted, however, when using N-aliphatic-substituted β-keto amides as the partners of N-aryl β-keto amides under the same conditio
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Fischer, Christian B., Kurt Polborn, Harald Steininger, and Hendrik Zipse. "Synthesis and Solid-State Structures of Alkyl-Substituted 3-Cyano-2-pyridones." Zeitschrift für Naturforschung B 59, no. 10 (2004): 1121–31. http://dx.doi.org/10.1515/znb-2004-1008.

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AbstractA series of 3-cyano-pyridones carrying a variety of alkyl substituents at C-5 and C-6 has been synthesized and their solid-state structures have been studied. Hydrogen bonding interactions between individual pyridone molecules lead either to the formation of symmetric dimers of the R22 (8) type or to helical chains of the C(4) type. Based on known and calculated structures for the 2-pyridone parent system, the solid-state structures can be divided in two groups representing cases with little external influence on the hydrogen bonding array (group A) and those with a larger external inf
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Dostanic, Jasmina, Natasa Valentic, Gordana Uscumlic, and Dusan Mijin. "Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3- cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenyldiazenyl)butanoates." Journal of the Serbian Chemical Society 76, no. 4 (2011): 499–504. http://dx.doi.org/10.2298/jsc100618044d.

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A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3- cyano-2-pyridones were prepared from ethyl 3-oxo-2-(substituted phenyldiazenyl)butanoates and cyanoacetamide in acetone using potassium hydroxide as a catalyst by simple refluxing the reaction mixture. The structure of these dyes was confirmed by FT-IR, NMR and UV-Vis spectroscopy.
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Mijin, Dusan, Gordana Uscumlic, and Natasa Valentic. "Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones." Journal of the Serbian Chemical Society 66, no. 8 (2001): 507–16. http://dx.doi.org/10.2298/jsc0108507m.

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A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the reaction of C-alkylation of ethyl acetoacetate. An investigation of the reaction conditions for the synthesis of 4-methyl-3-cyano-6-hydroxy-2-pyridone from cyanoacetamide and ethyl acetoacetate in eight different solvents was also performed. The ultraviolet absorption spectra of synthesized pyridones were measured in nine different solvents in the rang
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Gallagher, Timothy, and Aurélien Honraedt. "Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones." Synlett 27, no. 01 (2015): 67–69. http://dx.doi.org/10.1055/s-0035-1560469.

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Liu, Shitao, Jisen Li, Junjie Lin, Fujun Liu, Teng Liu, and Chao Huang. "Substituent-controlled chemoselective synthesis of multi-substituted pyridones via a one-pot three-component cascade reaction." Organic & Biomolecular Chemistry 18, no. 6 (2020): 1130–34. http://dx.doi.org/10.1039/c9ob02456e.

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Dissertations / Theses on the topic "4-Pyridones"

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Fernandez, Beatriz. "New functionalisation chemistry of 2- and 4-pyridones and related heterocycles." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21685.

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New methodology for the synthesis of several 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from commercially available 2-aminopyridines and β-oxo esters catalysed by Montmorillonite under solvent-free conditions in good yields. This methodology was expanded for the synthesis of 4H-pyrimido[1,2-a]pyrimidin-4-one derivatives from 2-aminopyrimidine and different β-keto esters. The new methodology for the synthesis of N-alkylated 6-methyl 2-pyridones and N-alkylated 2-methyl 4-pyridones, from commercially available starting materials was developed. For the synthesis of N-alkylated 6-methyl 2
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MacNevin, Christopher J. "Reactivity of substituted 4-Pyridones in normal and inverse demand Diels-Alder cycloaddition /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/macnevinc/christophermacnevin.pdf.

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Angello, Nicholas. "Development of a One Pot [4+2]/r[4+2] 2-Pyridone Synthesis and the Fluorescence of 2-Pyridone Azafluorenones." W&M ScholarWorks, 2018. https://scholarworks.wm.edu/etd/1550153876.

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We report the concise synthesis of several tricyclic 2-pyridones via a one pot sequence involving an aldol condensation, alkene isomerization, intramolecular Diels-Alder cycloaddition, and selective retro-Diels-Alder cycloreversion. The starting materials are synthesized in one step from cheap and commercially available precursors. The intermediate [2.2.2]diazabicycloalkene cycloadducts can be isolated. The retro-Diels-Alder occurs at easily accessible temperatures due to base acceleration. Simple derivatization of the tricyclic products afforded azafluorenones with unprecedented fluorescent a
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Hollick, Jonathan J. "Pyran-4-one, thiopyran-4-one and 4-pyridone inhibitors of the phosphatidylinositol 3-kinase-related kinase family." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402415.

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Kulyk, Svitlana. "PYRIDONE PHOTOCYCLOADDITION IN SYNTHESIS OF DIVERSE NATURAL AND UNNATURAL PRODUCTS." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/250995.

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Chemistry<br>Ph.D.<br>2-Pyridones are known to undergo a facile [4+4] photocycloaddition with themselves and other conjugated molecules. These transformations provide an access to complex molecular structures such as highly substituted cyclooctanoid derivatives, which normally represent a significant synthetic challenge. Moreover, the 2-pyridone photoadducts can be further elaborated into various biologically relevant products. The work presented here broadens the horizons of the [4+4] photocycloaddition in two distinct directions: 1) by utilizing [4+4] photocycloaddition in a total synthesis
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王慧貞. "[4+2] Cycloaddition Reactions of 4-Thio-Substituted-2-Pyridones." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/27972077383384254923.

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碩士<br>輔仁大學<br>化學系<br>91<br>Abstract This thesis mainly studies the [4+2] cycloaddition reactions of 4-thio-substituted-2-pyridones undergo , and discuss the effect of the thio group and N-substituents on the yield and regio- , stereo selectivity of the reaction. In the cycloaddition, if we choose suitable dienophiles such as maleimide derivatives to react with pyridones 6a and 6b , we can avoid the N→O migration side reaction, and can obtain the expect cycloaddition products. These results show that the tosyl group on the nitrogen plays an important role on the ster
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Pon-Won, Chen, and 陳鵬文. "Cycloaddition Reactions of 4-Sulfur-substituted-2-pyridones with Conjugated Dienes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/71875928223936994613.

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碩士<br>輔仁大學<br>化學系<br>95<br>This thesis mainly studies the [4+2] cycloaddition reactions of 4-sulfur-substituted 2-pyridones 6, 7, 18, and 20 with several electron-rich dienes, and explores the regio- and stereoselectivity of these reactions. Pyridone 6 reacts as a dienophile with cyclic and acyclic conjugated dienes to give the expected cycloaddition products. Pyridone 7, however, bearing a diene moiety itself, exhibits quite unusual reaction patterns with cyclopentadiene: it reacts as a diene at high temperatures, but reacts both as a dienophile and a diene at 50 oC. The reactivity of sulfox
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Hiebel, Anne-Cecile. "Derivatization of 2,3-dihydro-4-pyridones via the Nozaki-Hiyama-Kishi reaction." 2004. http://www.lib.ncsu.edu/theses/available/etd-05282004-161340/unrestricted/etd.pdf.

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Hsin-I, Hsieh, and 謝馨儀. "Nucleophilic Substitution Reactions of5-Bromo-4-sulfur-substituted 5,6-Dihydro-2-Pyridones." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45763674896989364064.

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碩士<br>輔仁大學<br>化學系<br>93<br>This thesis mainly studied the substitution reactions of bromo compound 5 and its sulfone derivative 19 with carbon nucleophiles, and explored the reactivity, solvent effect, and regioselectivity of the reaction. Compounds 5 or 19 underwent nucleophilic substitution reactions with dimethyl malonate anion,acetylacetone anion, ethyl acetoacetate anion, and dimethyl cuprate in a SN2' fashion. Aromatic derivative 21 underwent nucleophilic substitution reaction only with dimethyl malonate anion to give product 23, whereas its reaction with other nucleophiles yielded only
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Sahn, James Jeffrey. "Total synthesis of (+)-hyperaspine, advances toward the total synthesis of spirolucidine, and [2+2]-photochemical cycloadditions of 2,3-dihydro-4-pyridones." 2009. http://www.lib.ncsu.edu/theses/available/etd-12182008-133301/unrestricted/etd.pdf.

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Books on the topic "4-Pyridones"

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Kumpf, Joachim. Versuche zur Darstellung von Pyridin-3,4-chinonen und Synthesen von 3-Hydroxy-4-pyridonen. 1999.

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Book chapters on the topic "4-Pyridones"

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Makkar, Harinder P. S., P. Siddhuraju, and Klaus Becker. "L-Mimosine (β-(3-Hydroxy-4-Pyridone-1-yl)-L-Alanine)." In Plant Secondary Metabolites. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-425-4_8.

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Vittimberga, Bruno M., John Cosgrove, and Howard R. Heyman. "Photoinitiated Radical Reactions of l-(4′-Pyridyl)-4-Pyridone and its N-Protio and N-Methyl Derivatives. Dimerization and Polymerization Reactions." In Free Radicals in Synthesis and Biology. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0897-0_7.

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"4-Pyridones." In Metabolic Pathways of Agrochemicals. Royal Society of Chemistry, 2007. http://dx.doi.org/10.1039/9781847551382-00435.

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H. Asakawa, Ami, and Roman Manetsch. "A Comprehensive Review of 4(1H)-Quinolones and 4(1H)-Pyridones for the Development of an Effective Antimalarial." In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97084.

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Malaria is a global public health issue. Despite the efforts in malaria prevention, nearly half the world’s population is at risk of infection. Until present-day, researchers are struggling to design and discover an efficacious antimalarial. In comparison to most common antimalarial chemotypes that eliminate erythrocytic stages of P. falciparum, 4(1H)-quinolones and 4(1H)-pyridones exhibit antimalarial activity against multiple stages of the parasite. They have potential to treat blood stages of multidrug resistant P. falciparum malaria, eradicate dormant exoerythro stages of relapsing malaria
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Sieburth, Scott McN. "The inter-and intramolecular [4+4] photocycloaddition of 2-pyridones and its application to natural product synthesis." In Advances in Cycloaddition. Elsevier, 1999. http://dx.doi.org/10.1016/s1052-2077(99)80005-5.

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Taber, Douglass F. "Alkaloid Synthesis: (−)-L-Batzellaside A (Toyooka), Limazepine A (Zemribo), (+)-Febrifugine (Pansare), Amathaspiramide F (Tambar), Allomatrine (Brown), Lyconadine C (Waters), Tabersonine (Andrade)." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0057.

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Naoki Toyooka of the University of Toyama prepared (Eur. J. Org. Chem. 2013, 2841) the lactam 1 from commercial tri-O-benzyl-D-glucal. Reduction with Dibal followed by coupling of the intermediate with allyltrimethylsilane delivered the piper­idine 2, that was carried on to (−)-L-batzellaside A 3. Ronalds Zemribo of the Latvian Institute of Organic Synthesis effected (Org. Lett. 2013, 15, 4406) Ireland–Claisen rearrangement of the lactone 4 to give the pyrroli­dine 5 with high geometric control. This was readily converted to limazepine E 6. Sunil V. Pansare of Memorial University used (Synthes
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"Kap. 5: Elektrophile Agentien – neue Entwicklungen und präparative Anwendungen." In Von Aromaten und Heterocyclen zur Bio- und Nanotechnologie. GNT-Verlag GmbH, 2023. http://dx.doi.org/10.47261/1551-5.

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5.1 Die Friedel-Crafts-Acylierung von Aromaten – Carbonsäure-trifluormethansulfonsäureanhydride 5.2 Neue Halogen- und Schwefelelektrophile Sulfonsäuretriflate – ausgezeichnete Sulfonylierungsagentien 5.3 Carbonsäure-dihalogenphosphorsäureanhydride 5.4 2- und 4-Pyridone – ideale Austrittsgruppen für selektive Acylierungen
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Lambert, Tristan H. "Reactions of Alkenes." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0031.

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Paul J. Chirik at Princeton University reported (Science 2012, 335, 567) an iron catalyst that hydrosilylates alkenes with anti-Markovnikov selectivity, as in the conversion of 1 to 2. A regioselective hydrocarbamoylation of terminal alkenes was developed (Chem. Lett. 2012, 41, 298) by Yoshiaki Nakao at Kyoto University and Tamejiro Hiyama at Chuo University, which allowed for the chemoselective conversion of diene 3 to amide 4. Gojko Lalic at the University of Washington reported (J. Am. Chem. Soc. 2012, 134, 6571) the conversion of terminal alkenes to tertiary amines, such as 5 to 6, with an
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Taber, Douglass F. "Stereocontrolled C-N Ring Construction: The Pyne Synthesis of Hyacinthacine B 3." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0054.

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Keiji Maruoka of Kyoto University found (Organic Lett. 2010, 12, 1668) that the diazo amide 1 derived from the Oppolzer sultam condensed with the imine 2 to give the aziridine 3 with high stereocontrol. Andrei K. Yudin of the University of Toronto observed (Angew. Chem. Int. Ed. 2010, 49, 1607) that the unprotected aziridine aldehyde 4, which exists as a mixture of dimers, condensed smoothly with the Ohira reagent 5 to give the alkynyl aziridine 6. David M. Hodgson of the University of Oxford successfully (Angew. Chem. Int. Ed. 2010, 49, 2900) deprotonated the azetidine thioamide 7 to give, af
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Taber, Douglass F. "The Overman Synthesis of (-)-Actinophyllic Acid." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0103.

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(-)-Actinophyllic acid 3, isolated from Alstonia actinophylla, is a promising inhibitor of TAFIa/hippicuricase (0.84 μm). Larry E. Overman of the University of California, Irvine, envisioned (J. Am. Chem. Soc. 2010, 132, 4894) a bold route to 3 based on the aza-Cope/ intramolecular Mannich reorganization of 1 to 3. The absolute configuration of 1 and thus of 3 was set by Noyori hydrogenation of the enone 4. Ozonolysis followed by acetylation delivered the pyridone 6 as an inconsequential mixture of diastereomers. The ketone 9 was assembled by condensation of dimethyl malonate 8 with the acid c
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Conference papers on the topic "4-Pyridones"

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Gama, Fernando H. de Souza, and Simon J. Garden. "The use of 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD) in multicomponent reactions. Synthesis of acetoacetanilides, pyridones and dihydropyrimidines." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0273-1.

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Ilinca, Theodora, Doina Manaila-Maximean, Paul Ganea, Iuliana Pasuk, and Viorel Circu. "Polarized emission and dielectric studies of novel lanthanidomesogens based on 4-pyridone ligands." In Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies 2020, edited by Marian Vladescu, Ionica Cristea, and Razvan D. Tamas. SPIE, 2020. http://dx.doi.org/10.1117/12.2572109.

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Tadić, Julijana D., Jelena M. Lađarević, Maja D. Marković, Aleksandra M. Ivanovska, Mirjana M. Kostić, and Dušan Ž. Mijin. "A NOVEL AZO-AZOMETHINE DYE: SYNTHESIS, DYEING AND ANTIOXIDANT PROPERTIES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.379t.

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Schiff bases, or azomethine compounds, are commonly employed in the fields of organic synthesis, metal complexes, materials, and engineering. Especially, they have gained importance in medicinal researches, considering their antimicrobial, anticancer, anti- inflammatory, and antioxidant properties. On the other side, azo dyes are the most significant group of synthetic dyes, utilized in textile fiber dyeing. Conjugation of Schiff bases with azo compounds leads to the class of azo-azomethine dyes, which have numerous applications related to their coloration and biological properties. Viscose is
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Fan, Junhao, Jian Li, Kaihe Lv, et al. "Preparation and Mechanism Study of Resistant to High Temperature and High Salt Hyperbranched Fluid Loss Reducer for Water-Based Drilling Fluid." In GOTECH. SPE, 2025. https://doi.org/10.2118/224789-ms.

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Abstract It is difficult to regulate the flow and filtration characteristics of water-based drilling fluids(WBDFs) in complex formation conditions such as extreme thermal conditions, elevated pressure environments, and hypersaline circumstances. Conventional fluid loss reducer) are mainly linear structure polymers, which have large self-viscosity and have a great impact on the flow and filtration characteristics. In ultra-high temperature and hypersaline circumstances, polymer molecular chains are prone to conformational changes such as crosslinking and twisting, resulting in uncontrollable rh
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