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Journal articles on the topic '6-OHDA animal model'

Author: Grafiati

Published: 5 September 2021

Last updated: 29 July 2025

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1

Barata-Antunes, Sandra, Fábio G. Teixeira, Bárbara Mendes-Pinheiro, et al. "Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease." International Journal of Molecular Sciences 21, no. 10 (2020): 3459. http://dx.doi.org/10.3390/ijms21103459.

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Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. The neurodegeneration leading to incapacitating motor abnormalities mainly occurs in the nigrostriatal pathway due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Several animal models have been developed not only to better understand the mechanisms underlying neurodegeneration but also to test the potential of emerging disease-modifying therapies. However, despite aging being the main risk factor for developing idiopathic PD, most of the studies do not use aged animals.

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2

Kosksi, Tahsine, Arem Selmi, Sahar Mani, et al. "Antinociceptive effect of melatonin in the animal model of Parkinson’s Disease." Melatonin Research 4, no. 3 (2021): 440–52. http://dx.doi.org/10.32794/mr112500104.

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Several animal experimental and clinical studies have shown the effectiveness of melatonin in the treatment of some symptoms of Parkinson&#39;s disease (PD). However, the antinociceptive effect of melatonin against pain associated to PD has not been fully investigated. Thus, the present study investigated the possible antiallodynic and antinociceptive effects of acute and chronic melatonin treatments in Parkinsonian model of rats. This model was created by unilateral injection of 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle (MFB). The electronic von Frey test was used t

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3

Morris, Jill K., Gregory L. Bomhoff, John A. Stanford, and Paige C. Geiger. "Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299, no. 4 (2010): R1082—R1090. http://dx.doi.org/10.1152/ajpregu.00449.2010.

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Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to address the relationship between insulin resistance and nigrostriatal dopamine (DA) in a preclinical animal model. High-fat feeding in rodents is an established model of insulin resistance, characterized by increased adiposity, systemic oxidative stress, and hyperglycemia. We subjected rats to a normal chow or high-fat diet for 5 wk before infusing 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our goal

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Song, Dan, Kangli Ma, Alexei Verkhratsky, and Liang Peng. "l-Dopa and Fluoxetine Upregulate Astroglial 5-HT2B Receptors and Ameliorate Depression in Parkinson’s Disease Mice." Neuroglia 1, no. 1 (2018): 48–62. http://dx.doi.org/10.3390/neuroglia1010006.

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Here, we report the association between depressive behavior (anhedonia) and astroglial expression of 5-hydroxytryptamine receptor 2B (5-HT2B) in an animal model of Parkinson’s disease, induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Expression of the 5-HT2B receptor at the mRNA and protein level was decreased in the brain tissue of 6-OHDA-treated animals with anhedonia. Expression of the 5-HT2B receptor was corrected by four weeks treatment with either l-3,4-dihydroxyphenylalanine (l-dopa) or fluoxetine. Simultaneously, treatment with l-dopa abolished 6-OHDA eff

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5

Austin, Publishing Group. "The Neuroprotective Effect of Clove Essential Oil Against 6-Ohda-Induced Cell Death in Sh-Sy5y and A Rat Model of Parkinson's Disease." Austin Alzheimer's and Parkinson's Disease 6, no. 2 (2023): 1039. https://doi.org/10.26420/austinalzheimersjparkinsonsdis.2023.1039.

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Abstract Parkinson’s Disease (PD) is the second most prevalent neurological disorder. Natural therapies are becoming more popular for preventing disease onset. Clove Essential Oil (CEO), a potent antioxidant derived from Syzygium aromaticum buds, was tested in vitro (SH-SY5Y) and in vivo (PD rat model) for its ability to protect against 6-OHDA-induced cell death. Twenty-four hours of SH-SY5Y cells’ exposure to 6-OHDA (100μM) drastically decreased cell viability. At doses lesser than 20μg/ml, CEO and its main component Eugenol (EG) had no cytotoxic effect on SH-SY5Y. CEO and E

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6

Kim, Bohye, Poornima D. E. Weerasinghe-Mudiyanselage, Mary Jasmin Ang, et al. "Changes in the Neuronal Architecture of the Hippocampus in a 6-Hydroxydopamine-Lesioned Rat Model of Parkinson Disease." International Neurourology Journal 26, Suppl 2 (2022): S94–105. http://dx.doi.org/10.5213/inj.2244252.126.

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Purpose: Parkinson disease (PD) is a progressive neurodegenerative disorder in which dopaminergic (DAergic) systems are destroyed (particularly in the nigrostriatal system), causing both motor and nonmotor symptoms. Hippocampal neuroplasticity is altered in PD animal models, resulting in nonmotor dysfunctions. However, little is known about the precise mechanism underlying the hippocampal dysfunctions in PD.Methods: Striatal 6-hydroxydopamine (6-OHDA) infusions were performed unilaterally in adult Sprague Dawley rats. Both motor and nonmotor symptoms alongside the expression of tyrosine hydrox

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7

Dantas, Camila G., Ailma O. da Paixão, Tássia L. G. M. Nunes, et al. "Africanized Bee Venom (Apis mellifera Linnaeus): Neuroprotective Effects in a Parkinson’s Disease Mouse Model Induced by 6-hydroxydopamine." Toxics 10, no. 10 (2022): 583. http://dx.doi.org/10.3390/toxics10100583.

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This study evaluated the neuroprotective effects of the Africanized bee venom (BV) and its mechanisms of action after 6-hydroxydopamine-(6-OHDA)-induced lesion in a mice model. Prior to BV treatment, mice received intrastriatal microinjections of 6-OHDA (no induced dopaminergic neuronal death) or ascorbate saline (as a control). BV was administered subcutaneously at different dosages (0.01, 0.05 or 0.1 mg·Kg−1) once every two days over a period of 3 weeks. The open field test was carried out, together with the immunohistochemical and histopathological analysis. The chemical composition of BV w

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Ariza, D., L. Sisdeli, C. C. Crestani, R. Fazan, and M. C. Martins-Pinge. "Dysautonomias in Parkinson's disease: cardiovascular changes and autonomic modulation in conscious rats after infusion of bilateral 6-OHDA in substantia nigra." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 3 (2015): H250—H257. http://dx.doi.org/10.1152/ajpheart.00406.2014.

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It is important to elucidate the mechanism of dysautonomias in patients with Parkinson's disease; therefore, this study aimed to investigate the cardiovascular and autonomic changes that occur in an animal model of Parkinsonism. Adult male Wistar rats were anesthetized before bilateral microinfusions of 6-hydroxydopamine (6-OHDA) into the substantia nigra. The sham group underwent the same surgical procedure but received vehicle. After 7 days, the mean arterial pressure (MAP) and heart rate (HR) were measured, and various drugs were injected into conscious rats through cannulas previously impl

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9

Xie, Caroline, and Asheeta A. Prasad. "Probiotics Treatment Improves Hippocampal Dependent Cognition in a Rodent Model of Parkinson’s Disease." Microorganisms 8, no. 11 (2020): 1661. http://dx.doi.org/10.3390/microorganisms8111661.

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Parkinson’s disease (PD) is a neurological disorder with motor dysfunction and a number of psychiatric symptoms. Symptoms such as anxiety and cognitive deficits emerge prior to motor symptoms and persist over time. There are limited treatments targeting PD psychiatric symptoms. Emerging studies reveal that the gut microbe is altered in PD patients. Here we assessed the effect of a probiotic treatment in a rat model of PD. We used the neurotoxin (6-hydroxydopamine, 6-OHDA) in a preclinical PD model to examine the impact of a probiotic treatment (Lacticaseibacillus rhamnosus HA-114) on anxiety a

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Masini, Débora, Carina Plewnia, Maëlle Bertho, Nicolas Scalbert, Vittorio Caggiano, and Gilberto Fisone. "A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson’s Disease for the Study of Non-Motor Symptoms." Biomedicines 9, no. 6 (2021): 598. http://dx.doi.org/10.3390/biomedicines9060598.

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In Parkinson’s disease (PD), a large number of symptoms affecting the peripheral and central nervous system precede, develop in parallel to, the cardinal motor symptoms of the disease. The study of these conditions, which are often refractory to and may even be exacerbated by standard dopamine replacement therapies, relies on the availability of appropriate animal models. Previous work in rodents showed that injection of the neurotoxin 6-hydroxydopamine (6-OHDA) in discrete brain regions reproduces several non-motor comorbidities commonly associated with PD, including cognitive deficits, depre

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Larisch, R., H. Vosberg, M. Beu, et al. "In vivo imaging neurotransmitter function." Nuklearmedizin 50, no. 04 (2011): 155–56. http://dx.doi.org/10.3413/nukmed-0371-10-12.

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SummaryThis article gives an overview of those small animal imaging studies which have been conducted on neurotransmitter function in the rat 6-hydoxydopamine (6-OHDA) model of Parkinson’s disease, and discusses findings with respect to the outcome of clinical studies on Parkinsonian patients.

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Vecchia, Débora Dalla, Marissa Giovanna Schamne, Marcelo Machado Ferro, et al. "Effects of Hypericum perforatum on turning behavior in an animal model of Parkinson's disease." Brazilian Journal of Pharmaceutical Sciences 51, no. 1 (2015): 111–15. http://dx.doi.org/10.1590/s1984-82502015000100012.

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Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg

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Abuirmeileh, Amjad N., Sawsan M. Abuhamdah, Asser Ashraf, and Karem H. Alzoubi. "Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson’s disease: Behavioral and neurochemical evidence." Restorative Neurology and Neuroscience 39, no. 2 (2021): 149–57. http://dx.doi.org/10.3233/rnn-201131.

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Background: Caffeine and taurine, which possess neuro-modulatory activity happen to be consumed together as part of the constituents of energy drinks, could have beneficial effects and prevent neuronal deterioration in Parkinson’s disease (PD). Objective: This study aimed to investigate behavioral and neurochemical effects of these two agents in an animal model of PD at two time points to evaluate possible neuro-protective or neuro-modulatory effects. Methods: Stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum was used to model PD-like behavior in animals. Motor behavior was a

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Pienaar, I. S., T. Schallert, V. A. Russell, L. A. Kellaway, J. A. Carr, and W. M. U. Daniels. "Early pubertal female rats are more resistant than males to 6-hydroxydopamine neurotoxicity and behavioural deficits: A possible role for trophic factors." Restorative Neurology and Neuroscience 25, no. 5-6 (2007): 513–26. https://doi.org/10.3233/rnn-2007-00408.

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Purpose: The infusion of 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway in rats is commonly used to produce an animal model of Parkinson's disease (PD). However, most studies use male adult animals only. The present study focused on possible gender differences in vulnerability to 6-OHDA during the early pubertal period when the effects exerted by gonadal steroid hormones are unpronounced. Methods: Young Sprague-Dawley rats, 35 days of age, were given a low vs. a higher dose of 6-OHDA in the medial forebrain bundle (MFB). Control rats received equivalent saline infusions. At 14 days

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15

Tseng, Kuan-Yin, Jui-Sheng Wu, Yuan-Hao Chen, Mikko Airavaara, Cheng-Yi Cheng, and Kuo-Hsing Ma. "Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model." Biomedicines 10, no. 6 (2022): 1446. http://dx.doi.org/10.3390/biomedicines10061446.

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Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, which leads to the motor control deficits. Recently, cell transplantation is a cutting-edge technique for the therapy of PD. Nevertheless, one key bottleneck to realizing such potential is allogenic immune reaction of tissue grafts by recipients. Cerebral dopamine neurotrophic factor (CDNF) was shown to possess immune-modulatory properties that benefit neurodegenerative diseases. We hypothesized that co-administration of CDNF with fetal ventral mesencephalic (VM) tissue can improve

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16

Stavrovskaya, Alla V., Dmitry N. Voronkov, Artem S. Olshansky, Anastasia S. Gushchina, and Nina G. Yamshikova. "The relationship between the location of a lesion in the striatal dopaminergic innervation and its behavioral manifestation in a 6-hydroxydopamine-induced model of Parkinson's disease in rats." Annals of Clinical and Experimental Neurology 15, no. 2 (2021): 42–49. https://doi.org/10.25692/acen.2021.2.6.

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Introduction. Animal modelling of Parkinsons disease is an essential step in studying disease pathogenesis and searching for effective treatment methods. An accurate assessment of the resulting model is critical. The aim of the study was to identify the correlation between the location of a lesion in the striatal dopaminergic innervation when the neurotoxin 6-hydroxydopamine (6-OHDA) was administered to rodents and the resulting behavior. Materials and methods. The study was carried out on 75 male Wistar rats that received intranigral injection of 3 l of 6-OHDA at a dose of 4 g/l. The animals

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Erkan, Orhan, Aysegul Gemici Sinen, Mustafa Munzuroğlu, Semir Özdemir, Narin Derin, and Osman Sinen. "Kisspeptin-54 Ameliorates Electrocardiographic Abnormalities in an Experimental Parkinson's Rat Model." Medical Records 7, no. 3 (2025): 541–6. https://doi.org/10.37990/medr.1669046.

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Aim: Cardiac complications may arise in association with Parkinson’s disease as age progresses. Kisspeptins are a group of peptides that mediate their physiological functions by binding to the GPR54 receptor. This study aimed to investigate whether KP-54 has an effect on the electrical activity of the heart in an animal model of Parkinson's disease. Material and Method: Sprague-Dawley rats weighing between 290–310 g were used. An experimental hemiparkinsonian rat model was generated via stereotaxic injection of the neurotoxin 6-OHDA into the right medial forebrain bundle, effectively replicati

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de Araújo, Dayane Pessoa, Caren Nádia Soares De Sousa, Paulo Victor Pontes Araújo, et al. "Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/571378.

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This study aimed to investigate behavioral and neurochemical effects ofα-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity.α-Lipoic acid decreased body rotations induced by apomorphine,

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Yiğit, Esra Nur, Ekin Sönmez, Melis Savaşan Söğüt, Tunahan Çakır, and Işıl Aksan Kurnaz. "Validation of an In-Vitro Parkinson’s Disease Model for the Study of Neuroprotection." Proceedings 2, no. 25 (2018): 1559. http://dx.doi.org/10.3390/proceedings2251559.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease with an estimation of 10 million people living with the disease and it is increasing in prevalence every year. Familial cases of PD are source of valuable information to determine genetical risk factors yet sporadic cases can emerge from distinct mechanisms so, identifying common pathways of familial and sporadic cases of PD may provide worthwhile insights to determine underlying mechanisms through the progression. LRRK2 mutations are the most common indicators of both sporadic and familial cases of PD and α-synuclein

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Fiametti, Louise Oliveira, Claudia Neves Correa, and Leandro Mantovani de Castro. "Peptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model." Zebrafish 18, no. 1 (2021): 55–65. http://dx.doi.org/10.1089/zeb.2020.1945.

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Ham, Sangwoo, Heejeong Kim, Jin-Ha Yoon, et al. "Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson’s Disease." International Journal of Molecular Sciences 20, no. 21 (2019): 5481. http://dx.doi.org/10.3390/ijms20215481.

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The motor and nonmotor symptoms of Parkinson’s disease (PD) correlate with the formation and propagation of aberrant α-synuclein aggregation. This protein accumulation is a pathological hallmark of the disease. Our group recently showed that peucedanocoumarin III (PCIII) possesses the ability to disaggregate β sheet aggregate structures, including α-synuclein fibrils. This finding suggests that PCIII could be a therapeutic lead compound in PD treatment. However, the translational value of PCIII and its safety information have never been explored in relevant animal models of PD. Therefore, we f

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Lee, Jin-Suk, Ji-Yong Lee, Won-Gil Cho, Young-Chul Yang, and Byung-Pil Cho. "Relationship between Microglial Activation and Dopaminergic Neuronal Loss in 6-OHDA-induced Parkinsonian Animal Model." Korean Journal of Physical Anthropology 26, no. 1 (2013): 13. http://dx.doi.org/10.11637/kjpa.2013.26.1.13.

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Joshi, Nancy, Neetesh Kumar Jain та Narendra Silawat. "Effect of PPAR α/γ agonist on Behavioural Alterations in 6-OHDA induced Parkinson Disease". International Journal of Medical Sciences and Pharma Research 8, № 2 (2022): 24–28. http://dx.doi.org/10.22270/ijmspr.v8i2.33.

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AIM- The aim of present research work aimed to investigate the neuroprotective potential of saroglitazor in experimental animal model of neurodegenerative disease. MATERIAL & METHODS- Sixty Male Wistar albino rats (150-200 gm) were obtained from the Central Animal House of Pharmaceutical Sciences, India. The tablets of 4 mg Saroglitazar (SG), were weighed and finely powdered and then transferred into a 10-ml calibrated flask, dissolved in 4 ml sterile saline solution (0.9% NaCl), swirled and sonicated for 5 min, completed to volume with saline, and shaken well for 15 min immediately before

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El Nebrisi, Eslam, Hayate Javed, Shreesh K. Ojha, Murat Oz та Safa Shehab. "Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson’s Disease is Mediated by α7-Nicotinic Receptors". International Journal of Molecular Sciences 21, № 19 (2020): 7329. http://dx.doi.org/10.3390/ijms21197329.

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Parkinson’s disease (PD) is a common neurodegenerative disorder, characterized by selective degeneration of dopaminergic nigrostriatal neurons. Most of the existing pharmacological approaches in PD consider replenishing striatal dopamine. It has been reported that activation of the cholinergic system has neuroprotective effects on dopaminergic neurons, and human α7-nicotinic acetylcholine receptor (α7-nAChR) stimulation may offer a potential therapeutic approach in PD. Our recent in-vitro studies demonstrated that curcumin causes significant potentiation of the function of α7-nAChRs expressed

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Love, R. M., R. L. Branton, J. Karlsson, P. Brundin, and D. J. Clarke. "Effects of Antioxidant Pretreatment on the Survival of Embryonic Dopaminergic Neurons In Vitro and following Grafting in an Animal Model of Parkinson's Disease." Cell Transplantation 11, no. 7 (2002): 653–62. http://dx.doi.org/10.3727/000000002783985431.

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The effect of pretreating cell suspensions of embryonic rat ventral mesencephala (VM) with antioxidant combinations on the survival of dopaminergic (DA) neurons was studied in vitro and following transplantation into the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease. The in vitro experiments examined the effects of two thiol antioxidants, N-acetyl-l-cysteine (NAC) and reduced glutathione (GSH), and a member of the lazaroid family of 21-aminosteroids, U-83836E, singly and in combination, on survival of DA neurons derived from dissociated E14 rat VM tissue. For

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Zeljkovic Jovanovic, Milica, Jelena Stanojevic, Ivana Stevanovic, et al. "Intermittent Theta Burst Stimulation Improves Motor and Behavioral Dysfunction through Modulation of NMDA Receptor Subunit Composition in Experimental Model of Parkinson’s Disease." Cells 12, no. 11 (2023): 1525. http://dx.doi.org/10.3390/cells12111525.

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the progressive degeneration of the dopaminergic system, leading to a variety of motor and nonmotor symptoms. The currently available symptomatic therapy loses efficacy over time, indicating the need for new therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) has emerged as one of the potential candidates for PD therapy. Intermittent theta burst stimulation (iTBS), an excitatory protocol of rTMS, has been shown to be beneficial in several animal models of neurodegeneration, in

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Wattanathorn, Jintanaporn, and Chatchada Sutalangka. "Laser Acupuncture at HT7 Acupoint Improves Cognitive Deficit, Neuronal Loss, Oxidative Stress, and Functions of Cholinergic and Dopaminergic Systems in Animal Model of Parkinson’s Disease." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/937601.

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To date, the therapeutic strategy against cognitive impairment in Parkinson’s disease (PD) is still not in satisfaction level and requires novel effective intervention. Based the oxidative stress reduction and cognitive enhancement induced by laser acupuncture at HT7, the beneficial effect of laser acupuncture at HT7 against cognitive impairment in PD has been focused. In this study, we aimed to determine the effect of laser acupuncture at HT7 on memory impairment, oxidative stress status, and the functions of both cholinergic and dopaminergic systems in hippocampus of animal model of PD. Male

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Tsai, Wan-Ling, Hsin-Yung Chen, Ying-Zu Huang, et al. "Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease." Behavioural Neurology 2019 (December 5, 2019): 1–10. http://dx.doi.org/10.1155/2019/4829572.

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Background. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder affecting 7–10 million individuals. The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. Recent animal studies have demonstrated that physical exercise improves behavioral and neuropathological deficits in PD. However, the exact underlying mechanism underlying this effect remains unclear. In this study, we investigated whether long-term exercise has neuroprotective effect

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Kolmančič, Kaja, Marko Živin, and Maja Zorović. "Modulation by Estradiol of L-Dopa-Induced Dyskinesia in a Rat Model of Post-Menopausal Hemiparkinsonism." Life 12, no. 5 (2022): 640. http://dx.doi.org/10.3390/life12050640.

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Treatment with levodopa (L-dopa) in Parkinson’s disease (PD) leads to involuntary movements termed L-dopa-induced dyskinesia (LID). There are contradictory data about the influence of hormone therapy in female PD patients with LID and of 17-β-estradiol (E2) on animal correlates of LID-abnormal involuntary movements (AIMs). Our aim was to characterize the influence of E2 on motor impairment and AIMs in ovariectomized 6-hydroxydopamine (6-OHDA) rat model of PD. Half of the rats received empty and the other half implants filled with E2. Following the 6-OHDA surgery, the rats received daily treatm

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Kolmančič, Kaja, Marko Živin, and Maja Zorović. "Modulation by Estradiol of L-Dopa-Induced Dyskinesia in a Rat Model of Post-Menopausal Hemiparkinsonism." Life 12, no. 5 (2022): 640. http://dx.doi.org/10.3390/life12050640.

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Treatment with levodopa (L-dopa) in Parkinson’s disease (PD) leads to involuntary movements termed L-dopa-induced dyskinesia (LID). There are contradictory data about the influence of hormone therapy in female PD patients with LID and of 17-β-estradiol (E2) on animal correlates of LID-abnormal involuntary movements (AIMs). Our aim was to characterize the influence of E2 on motor impairment and AIMs in ovariectomized 6-hydroxydopamine (6-OHDA) rat model of PD. Half of the rats received empty and the other half implants filled with E2. Following the 6-OHDA surgery, the rats received daily treatm

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Lee, Hee Ju, Basanta Dhodary, Ju Yong Lee, et al. "Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction of Humulus japonicus and It’s Protective Effects against Parkinson’s Disease Mouse Model." Molecules 24, no. 7 (2019): 1435. http://dx.doi.org/10.3390/molecules24071435.

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Humulus japonicus is an annual plant belonging to the Cannabacea family, and it has been traditionally used to treat pulmonary tuberculosis, dysentery, chronic colitis, and hypertension. We investigated the active components against Parkinson’s disease from H. japonicus fraction (HJF) using high performance liquid chromatography (HPLC) coupled with quadruple-time-of-flight mass spectroscopy (qTOF-MS) and NMR. Fourteen compounds were isolated from HJF, including one new compound, using HPLC-qTOF-MS and NMR. The major compounds of HJF were luteolin-7-O-glucoside and apigenin-7-O-glucoside, and t

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Biolchi, Andréia Mayer, Danilo Gustavo Rodrigues de Oliveira, Henrique de Oliveira Amaral, et al. "Fraternine, a Novel Wasp Peptide, Protects against Motor Impairments in 6-OHDA Model of Parkinsonism." Toxins 12, no. 9 (2020): 550. http://dx.doi.org/10.3390/toxins12090550.

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Parkinson’s disease (PD) is a progressive neurodegenerative condition that affects the Central Nervous System (CNS). Insect venoms show high molecular variability and selectivity in the CNS of mammals and present potential for the development of new drugs for the treatment of PD. In this study, we isolated and identified a component of the venom of the social wasp Parachartergus fraternus and evaluated its neuroprotective activity in the murine model of PD. For this purpose, the venom was filtered and separated through HPLC; fractions were analyzed through mass spectrometry and the active frac

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Turco, Luigia, Nicola Opallo, Elisabetta Buommino, et al. "Zooming into Gut Dysbiosis in Parkinson’s Disease: New Insights from Functional Mapping." International Journal of Molecular Sciences 24, no. 11 (2023): 9777. http://dx.doi.org/10.3390/ijms24119777.

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Gut dysbiosis has been involved in the pathogenesis and progression of Parkinson’s disease (PD), but the mechanisms through which gut microbiota (GM) exerts its influences deserve further study. Recently, we proposed a two-hit mouse model of PD in which ceftriaxone (CFX)-induced dysbiosis amplifies the neurodegenerative phenotype generated by striatal 6-hydroxydopamine (6-OHDA) injection in mice. Low GM diversity and the depletion of key gut colonizers and butyrate producers were the main signatures of GM alteration in this model. Here, we used the phylogenetic investigation of communities by

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Wei, Renrong, Cuiping Rong, Qingfeng Xie, et al. "Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson’s Disease through the Inflammation Pathway." Evidence-Based Complementary and Alternative Medicine 2019 (December 21, 2019): 1–11. http://dx.doi.org/10.1155/2019/2529641.

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Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN)-striatum circuit, which is associated with glial activation and consequent chronic neuroinflammation. Optimized Yinxieling Formula (OYF) is a Chinese medicine that exerts therapeutical effect and antiinflammation property on psoriasis. Our previous study has proven that pretreatment with OYF could regulate glia-mediated inflammation in an acute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Given that PD is a chronic degeneration disorder, this

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Hsieh, Tsung-Hsun, Xiao-Kuo He, Hui-Hua Liu, et al. "Early Repetitive Transcranial Magnetic Stimulation Exerts Neuroprotective Effects and Improves Motor Functions in Hemiparkinsonian Rats." Neural Plasticity 2021 (December 27, 2021): 1–14. http://dx.doi.org/10.1155/2021/1763533.

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Repetitive transcranial magnetic stimulation (rTMS) is a popular noninvasive technique for modulating motor cortical plasticity and has therapeutic potential for the treatment of Parkinson’s disease (PD). However, the therapeutic benefits and related mechanisms of rTMS in PD are still uncertain. Accordingly, preclinical animal research is helpful for enabling translational research to explore an effective therapeutic strategy and for better understanding the underlying mechanisms. Therefore, the current study was designed to identify the therapeutic effects of rTMS on hemiparkinsonian rats. A

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Carey, Robert J. "Dopamine receptors mediate drug-induced but not Pavlovian conditioned contralateral rotation in the unilateral 6-OHDA animal model." Brain Research 515, no. 1-2 (1990): 292–98. http://dx.doi.org/10.1016/0006-8993(90)90609-f.

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Kuter, Katarzyna Z., Łukasz Olech, Urszula Głowacka, and Martyna Paleczna. "Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson’s Disease. Exploration of Brain and Liver Energy Metabolism Markers." International Journal of Molecular Sciences 22, no. 14 (2021): 7556. http://dx.doi.org/10.3390/ijms22147556.

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The benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson’s disease (PD). There are multiple theoretical reasons but very little actual experimental proof or clinical trials. We examined the long-term effects of the ketogenic diet in an animal model of early PD. A progressive, selective dopaminergic medium size lesion was induced by 6-OHDA injection into the medial forebrain bundle. Animals were kept on the stringent ketogenic diet (1% carbohydrates, 8% protein, 70% fat) for 3 weeks prior and 4 weeks after the brain operat

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Fan, Hueng-Chuen, Yu-Kang Chang, Jeng-Dau Tsai, et al. "The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder." Cell Transplantation 29 (January 1, 2020): 096368972094741. http://dx.doi.org/10.1177/0963689720947416.

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While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan’s Longitudinal Health Insurance Database 2000 to provide the significant nationwide population-based evidence of an increased risk of PD among ADHD patients, and the connection between the two conditions was not the result of other comorbidities. Moreover, this study showed that the patients with PD were 2.

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Caballero, Miguel, Fabiana Núñez, Siobhán Ahern, et al. "Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD)." Neuroscience Letters 494, no. 1 (2011): 44–48. http://dx.doi.org/10.1016/j.neulet.2011.02.050.

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Prasad, E. Maruthi, and Shih-Ya Hung. "Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson’s Disease." Antioxidants 9, no. 10 (2020): 1007. http://dx.doi.org/10.3390/antiox9101007.

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Currently, neurodegenerative diseases are a major cause of disability around the world. Parkinson’s disease (PD) is the second-leading cause of neurodegenerative disorder after Alzheimer’s disease. In PD, continuous loss of dopaminergic neurons in the substantia nigra causes dopamine depletion in the striatum, promotes the primary motor symptoms of resting tremor, bradykinesia, muscle rigidity, and postural instability. The risk factors of PD comprise environmental toxins, drugs, pesticides, brain microtrauma, focal cerebrovascular injury, aging, and hereditary defects. The pathologic features

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Chia, Shyh Jenn, Eng-King Tan, and Yin-Xia Chao. "Historical Perspective: Models of Parkinson’s Disease." International Journal of Molecular Sciences 21, no. 7 (2020): 2464. http://dx.doi.org/10.3390/ijms21072464.

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Parkinson’s disease (PD) is the most common movement disorder with motor and nonmotor signs. The current therapeutic regimen for PD is mainly symptomatic as the etio-pathophysiology has not been fully elucidated. A variety of animal models has been generated to study different aspects of the disease for understanding the pathogenesis and therapeutic development. The disease model can be generated through neurotoxin-based or genetic-based approaches in a wide range of animals such as non-human primates (NHP), rodents, zebrafish, Caenorhabditis (C.) elegans, and drosophila. Cellular-based diseas

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Li, Xiang-Yun, Guang-Hai Mei, Qiang Dong, et al. "Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease." Parkinson's Disease 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/931058.

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Aim. In this study we examined the influence of tetrandrine (Tet) on the neuroprotective effects of glutathione (GSH) in the 6-hydroxydopamine- (6-OHDA-) lesioned rat model of Parkinson’s disease (PD).Methods. Levels in the redox system, dopamine (DA) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (SN) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of GSH + Tet (or GSH) and/or L-3,4-dihydroxyphenylalanine (L-dopa) to PD rats. Ethics Committee of Huashan Hospital, Fudan University approved the protocol (

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Santiago, R. M., F. S. Tonin, J. Barbiero, et al. "The nonsteroidal antiinflammatory drug piroxicam reverses the onset of depressive-like behavior in 6-OHDA animal model of Parkinson’s disease." Neuroscience 300 (August 2015): 246–53. http://dx.doi.org/10.1016/j.neuroscience.2015.05.030.

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Brzozowski, M. J., S. Lopez Alcantara, M. M. Iravani, S. Rose, and P. Jenner. "P2.120 iNOS-but not nNOS-inhibition protects against 6-OHDA-induced nigral cell loss in an animal model of PD." Parkinsonism & Related Disorders 15 (December 2009): S122. http://dx.doi.org/10.1016/s1353-8020(09)70471-7.

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Haghdoost-Yazdi, Hashem, Hossein Piri, Reza Najafipour, et al. "Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model." Neurosciences 22, no. 1 (2017): 44–50. http://dx.doi.org/10.17712/nsj.2017.1.20160266.

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Bernal-Conde, Luis Daniel, Verónica Peña-Martínez, C. Alejandra Morato-Torres, et al. "Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson’s Disease Animal Model." Life 14, no. 6 (2024): 728. http://dx.doi.org/10.3390/life14060728.

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Parkinson’s disease (PD) caused by SNCA gene triplication (3XSNCA) leads to early onset, rapid progression, and often dementia. Understanding the impact of 3XSNCA and its absence is crucial. This study investigates the differentiation of human induced pluripotent stem cell (hiPSC)-derived floor-plate progenitors into dopaminergic neurons. Three different genotypes were evaluated in this study: patient-derived hiPSCs with 3XSNCA, a gene-edited isogenic line with a frame-shift mutation on all SNCA alleles (SNCA 4KO), and a normal wild-type control. Our aim was to assess how the substantia nigra

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Bartlett, L. E., and I. Mendez. "Dopaminergic Reinnervation of the Globus Pallidus by Fetal Nigral Grafts in the Rodent Model of Parkinson's Disease." Cell Transplantation 14, no. 2-3 (2005): 119–27. http://dx.doi.org/10.3727/000000005783983241.

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The current neural transplantation strategy for Parkinson's disease (PD) involves the dopaminergic reinnervation of the striatum (STR). Although up to 85% reinnervation of the STR has been attained by neural transplantation, functional recovery in animal models and transplanted patients is incomplete. This limitation may be due to an incomplete restoration of the dopaminergic input to other basal ganglia structures such as the external segment of the globus pallidus (GPe, homologue of the rodent GP), which normally receives dopaminergic input from the substantia nigra (SN). As part of our inve

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Vasava, Nimisha, and Vipul Gajera. "In Vivo Studies of various Antiparkinson’s agents: A Systematic Review." International Journal for Research in Applied Science and Engineering Technology 10, no. 11 (2022): 1448–64. http://dx.doi.org/10.22214/ijraset.2022.47603.

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Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder which is characterized by typical symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills. Although there is no definitive cure for PD, the extract of some medicinal plants and their ingredients have been suggested to relieve its symptoms and to prevent disability in patients. This review is focused on therapeutic effects of some anti-Parkinson’s agents. The findings presented in this review were collected from experimental studies in databases including PubMed, Web of Science and Google Scholar

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Lee, Joohyung, Paulo Pinares-Garcia, Hannah Loke, Seungmin Ham, Eric Vilain, and Vincent R. Harley. "Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease." Proceedings of the National Academy of Sciences 116, no. 33 (2019): 16577–82. http://dx.doi.org/10.1073/pnas.1900406116.

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Parkinson’s disease (PD) is a debilitating neurodegenerative disorder caused by the loss of midbrain dopamine (DA) neurons. While the cause of DA cell loss in PD is unknown, male sex is a strong risk factor. Aside from the protective actions of sex hormones in females, emerging evidence suggests that sex-chromosome genes contribute to the male bias in PD. We previously showed that the Y-chromosome gene, SRY, directly regulates adult brain function in males independent of gonadal hormone influence. SRY protein colocalizes with DA neurons in the male substantia nigra, where it regulates DA biosy

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Jing, X., H. Shi, C. Zhang, et al. "Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity." Neuroscience 286 (February 2015): 131–40. http://dx.doi.org/10.1016/j.neuroscience.2014.11.047.

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