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Journal articles on the topic '613.2:796.4 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Bowmaker, Graham A., Effendy, John D. Kildea, Eban N. de Silva, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXI Synthesis, Spectroscopy and Structural Systematics of Some 1 : 2 Binuclear Adducts of Silver(I) Compounds with Triphenylarsine, [(Ph3As)2Ag(µ-X)2Ag(AsPh3)2], X = Cl, Br, I, SCN." Australian Journal of Chemistry 50, no. 6 (1997): 627. http://dx.doi.org/10.1071/c96037.

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The syntheses and room-temperature single-crystal X-ray structural characterization of binuclear 1 : 2 adducts formed between silver(I) (pseudo-)halides, AgX, and triphenylarsine, AsPh3, for X = Cl, Br, I, SCN (1)–(4), are described. The chloride (1), obtained from 2-methylpyridine, is triclinic, P-1, a 10·410(2), b 12·716(2), c 14·196(6) Å, α 113·38(2), β 109·41(2), γ 75·08(1)°, Z = 1 (dimer); conventional R on F was 0·037 for No 3979 independent ‘observed’ (I > 3σ(I)) reflections. The bromide (2a), obtained from 2,6-dimethylpyridine, and iodide (3), obtained from a mixture of AgI/saturate

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is

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Latagliata, R., M. Breccia, P. Fazi, et al. "Long-Term Results of the GIMEMA LAP AIDA 0493 Amended Protocol in Elderly Patients with Acute Promyelocytic Leukemia (APL)." Blood 106, no. 11 (2005): 885. http://dx.doi.org/10.1182/blood.v106.11.885.885.

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Abstract In order to reduce toxicity in elderly patients with newly diagnosed APL, since 3/1997 the Italian cooperative group GIMEMA evaluated an amended AIDA protocol for patients aged &gt; 60 years, consisting of the same induction with ATRA and Idarubicin but only 1st consolidation course (Idarubicin + Cytarabine), followed by 2 years maintenance with ATRA alone. Up to now, 56 patients (25 males and 31 females, median age 66.2 years, 46 with PS 0-1 and 10 with PS 2) are fully evaluable. At onset, according to GIMEMA-PETHEMA risk score, 18 were low-risk(32.5%), 31 intermediate risk (55%)

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Talamo, G., D. F. Claxton, W. C. Ehmann, J. Mierski, W. Rybka, and S. Ibrahin. "Effect of mobilization chemotherapy with cyclophosphamide and etoposide on stem cell collection by lenalidomide." Journal of Clinical Oncology 27, no. 15_suppl (2009): 7096. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.7096.

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7096 Background: The combination of dexamethasone and lenalidomide is currently considered one of the standards of care for induction therapy of patients with multiple myeloma (MM) before autologous stem cell transplantation (ASCT). Increasing evidence suggests that lenalidomide impairs the ability to collect peripheral blood stem cells (PBSC). Methods: We retrospectively analyzed the outcomes of PBSC collections of MM patients who received induction therapy with dexamethasone and lenalidomide, and who were collected with either granulocyte-colony stimulating factor (G-CSF) alone, 10–16 mcg/Kg

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Sandhu, Shahneen, Shalini Subramaniam, Hayley Thomas, et al. "¹⁷⁷ Lu-PSMA-617 with ipilimumab (ipi) and nivolumab (nivo) in metastatic castration-resistant prostate cancer (mCRPC): An investigator-initiated phase 2 trial (EVOLUTION; ANZUP2001)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 5016. https://doi.org/10.1200/jco.2025.43.16_suppl.5016.

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5016 Background: LuPSMA improves progression-free survival (PFS) and overall survival (OS) in patients with mCRPC. Immune checkpoint inhibitors (ICI) have limited single-agent activity in mCRPC. Radiation may enhance ICI activity by inducing immunogenic tumor cell death and altering the tumor microenvironment. We evaluated the activity and safety of ipi plus nivo plus LuPSMA in mCRPC. Methods: Eligibility: prior androgen receptor pathway inhibitor therapy, PSMA-positive disease, normal organ function, no contraindications to ICIs, <= 1 line of chemotherapy. Randomized (1:2) to LuPSMA alone

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Xiang, L., A. Low, Y. Y. Leung, et al. "POS1413 INTERVAL BETWEEN SYMPTOM ONSET AND DIAGNOSIS AMONG PATIENTS WITH AUTOIMMUNE RHEUMATIC DISEASES IN A MULTI-ETHNIC ASIAN POPULATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 990.1–990. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1713.

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Background:The interval between symptom onset and diagnosis can often be longer than is ideal in autoimmune rheumatic diseases (ARDs).Objectives:We aimed to characterise this interval among patients newly diagnosed with ARDs in a multi-ethnic Asian population and to identify factors associated with a longer interval.Methods:We used Scott’s model of pathways to treatment to characterise the interval between symptom onset and diagnosis into 4 intervals: #1 between symptom onset and first seeking medical attention, #2 between first medical attention and rheumatology referral, #3 between rheumatol

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PENA-PEREIRA, Márcio Alexandre, Manoel Alves SOBREIRA-NETO, Emmanuelle SOBREIRA, et al. "Validation of the Brazilian Portuguese version of the Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ-BR)." Arquivos de Neuro-Psiquiatria 78, no. 10 (2020): 629–37. http://dx.doi.org/10.1590/0004-282x20200125.

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ABSTRACT Introduction: A diagnosis of rapid eye movement sleep behavior disorder (RBD) currently requires confirmation with polysomnography (PSG). However, PSG may not be sufficiently available. In these situations, a clinical diagnostic measure might be useful. Objective: To validate the Brazilian Portuguese version of RBD screening questionnaire (RBDSQ) for patients with Parkinson’s disease (PD). Methods: Using detailed clinical interviews and PSG analysis (diagnostic gold standard), a convenience sample of 69 subjects was divided into the following subgroups: patients with PD and RBD (PD+RB

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Dinca, Eduard B., Patricia de Lacy, John Yianni, et al. "Gamma Knife surgery for pediatric arteriovenous malformations: a 25-year retrospective study." Journal of Neurosurgery: Pediatrics 10, no. 5 (2012): 445–50. http://dx.doi.org/10.3171/2012.8.peds1241.

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Object The authors present their 25-year experience in treating pediatric arteriovenous malformations (AVMs) to allow comparisons with other historic studies and data in adults. Methods Data were collected from a prospectively maintained departmental database selected for age and supplemented by case note review and telephone interviews as appropriate. Results Three hundred sixty-three patients, ages 1–16 years (mean ± SD, 12 ± 3.2 years), underwent 410 treatments; 4 had planned 2-stage treatments and 43 were retreated subsequent to an initial partial response. Fifty-eight percent received gen

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dos Santos, Flávia A. R., Jadriane A. Xavier, Felipe C. da Silva, J. P. Jose Merlin, Marília O. F. Goulart, and H. P. Vasantha Rupasinghe. "Antidiabetic, Antiglycation, and Antioxidant Activities of Ethanolic Seed Extract of Passiflora edulis and Piceatannol In Vitro." Molecules 27, no. 13 (2022): 4064. http://dx.doi.org/10.3390/molecules27134064.

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The objective of this work was to investigate the antidiabetic, antiglycation, and antioxidant potentials of ethanolic extract of seeds of Brazilian Passiflora edulis fruits (PESE), a major by-product of the juice industry, and piceatannol (PIC), one of the main phytochemicals of PESE. PESE, PIC, and acarbose (ACB) exhibited IC50 for alpha-amylase, 32.1 ± 2.7, 85.4 ± 0.7, and 0.4 ± 0.1 µg/mL, respectively, and IC50 for alpha-glucosidase, 76.2 ± 1.9, 20.4 ± 7.6, and 252 ± 4.5 µg/mL, respectively. The IC50 of PESE, PIC, and sitagliptin (STG) for dipeptidyl-peptidase-4 (DPP-4) was 71.1 ± 2.6, 113

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Kobalava, Zh D., V. V. Kireeva, V. S. Chernomorets, E. A. Troitskaya, and Yu V. Stavtseva. "Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program." Russian Journal of Cardiology, no. 12 (December 28, 2019): 87–95. http://dx.doi.org/10.15829/1560-4071-2019-12-87-95.

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Aim. To study the effects of fixed-dose indapamide/perindopril combination on endothelial function and arterial stiffness in patients with uncontrolled stage 1-2 hypertension (HTN) and chronic kidney disease (CKD).Material and methods. Total of 100 patients with uncured or uncontrolled with ≥3 months antihypertensive therapy HTN and CKD G3 (67% females, mean age 59,1±12,5 years) were included in the study. Each patient took indapamide/perindop combination in accordance with 1 of 3 existing regimes (depending on doses) for 3 months. Primary aim was to assess the effects of indapamide/perindopri

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Roy, Ronald R., Patrick Wilson, Ronald R. Laski, et al. "Monitoring of Domestic and Imported Apples and Rice by the U.S. Food and Drug Administration Pesticide Program." Journal of AOAC INTERNATIONAL 80, no. 4 (1997): 883–94. http://dx.doi.org/10.1093/jaoac/80.4.883.

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Abstract In 1993-94, the U.S. Food and Drug Administration (FDA) conducted a statistically based study of pesticide residues in domestic and imported fresh apples and processed rice. For apples, 769 domestic and 1062 imported samples were collected and analyzed; 85% of the domestic and 86% of the imported samples had detectable residues. Benomyl, a widely used fungicide, was found with greatest frequency in domestic apples, while diphenylamine was found most often in imported apples. One domestic and 4 imported samples contained violative residues of pesticides for which there are no U.S. tole

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Leblond, Veronique, Sylvie Chevret, marie Sarah Dilhuydy, et al. "Phase II Trial In Advanced Waldenstrom Macroglobulinemia (WM) Patients With Bortezomib: Interest Of Addition Of Dexamethasone To Bortezomib On Behalf Of The French CLL/WM Intergroup (NCT 00777738)." Blood 122, no. 21 (2013): 4359. http://dx.doi.org/10.1182/blood.v122.21.4359.4359.

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Abstract Background Bortezomib (B) is an effective drug alone or in combination in naive and pretreated WM patients. The interest of high dose of dexamethasone (D) with bortezomib (B) has not been evaluated in WM patients and D is systematically added to bortezomib combination with or without Rituximab (R) (BD, BDR). However, D is responsible for side effects in elderly population. We tested in a phase II trial the efficacy and safety of the addition of D to B after 2 B cycles in patients with a stable or progressive disease (SD, PD). Patients and Methods Bortezomib was used at 1.3mg/m2 IV D1,

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Waterhouse, David, Amanda Shawky, Aanal Desai, et al. "Abstract 5946: Five-year real-world survival outcomes of patients with advanced non-small cell lung cancer receiving first-line immunotherapy-based regimens." Cancer Research 85, no. 8_Supplement_1 (2025): 5946. https://doi.org/10.1158/1538-7445.am2025-5946.

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Abstract Background: Five-year real-world outcomes of first-line (1L) immunotherapy (IO)-based regimens for advanced non-small cell lung cancer (aNSCLC) were assessed to describe how real-world outcomes correspond to those in clinical trials. Methods: Adult patients (pts) with aNSCLC from Flatiron Health database receiving 1L IO monotherapy or single-agent IO + chemotherapy from Jan 1, 2016 to Jun 30, 2024 were identified. Pts were excluded if they had EGFR/ALK mutations or unknown histology type. Overall survival (OS) and real-world progression-free survival (rwPFS) of each 1L treatment were

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Rizzari, Carmelo, Anja Moericke, Valentino Conter, et al. "Incidence of Hypersensitivity Reactions (HSR) Reactions (HSR) to Peg-Asparaginase (PEG-ASP) in 6136 Patients Treated in the AIEOP-BFM ALL 2009 Study Protocol." Blood 134, Supplement_1 (2019): 2589. http://dx.doi.org/10.1182/blood-2019-123448.

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Background and aim: The AIEOP-BFM ALL 2009 trial (https://www.clinicaltrials.gov/NCT01117441) is an international collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia (ALL) wherein PEG-ASP (Oncaspar®, Servier) was used as the front-line ASP product. Since HSR represent the most relevant limitation to the completion of ASP treatment schedules in the context of any study protocol, we evaluated the cumulative incidence of HSR following PEG-ASP treatment for better understanding the impact of this product on the HSR phenomenon in the context of the treatm

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Giné, Eva, Sílvia Beà, Alba Navarro, et al. "Risk of Central Nervous System (CNS) Involvement in Patients with Mantle Cell Lymphoma (MCL): Analysis of Clinico-Biological Factors in a Series of 283 Cases." Blood 124, no. 21 (2014): 1677. http://dx.doi.org/10.1182/blood.v124.21.1677.1677.

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Abstract Introduction: MCL is a mature B-cell neoplasm characterized by t(11;14) (q13;q32) and cyclin D1 (CCND1) overexpression. Molecular studies have revealed other alterations in cell-cycle regulation, DNA damage response and cell survival pathways, with a landscape of somatic mutations being recently identified. CNS involvement is a well known complication, occurring in 4-26% of MCL at five years, with an ominous significance. Although different clinical variables have been identified as risk factors for CNS infiltration, the biological parameters related to this complication have not been

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Patenaude, Jan, Gustavo Zarini, Michael McLean, and Susan Linke. "Effectiveness of a Tailored Dietary Program in Subjects With Fibromyalgia." Current Developments in Nutrition 5, Supplement_2 (2021): 856. http://dx.doi.org/10.1093/cdn/nzab047_019.

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Abstract Objectives We examined the effects of the Lifestyle Eating and Performance (LEAP) program to alleviate fibromyalgia-related symptoms. Methods The retrospective study included de-identified data of 33 subjects with fibromyalgia. Dietitians used the in-vitro Leukocyte Activation Assay-MRT (LAA-MRT) blood test results to develop the tailored LEAP program for each subject. The LAA-MRT measures white blood cells reactivity to scale the degree of an adverse immune response to 150 food and food-chemical antigens. The LEAP program is based on the principles of the oligoantigenic dietary appro

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Paschka, Peter, Richard F. Schlenk, Verena I. Gaidzik, et al. "IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication." Journal of Clinical Oncology 28, no. 22 (2010): 3636–43. http://dx.doi.org/10.1200/jco.2010.28.3762.

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Purpose To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations in acute myeloid leukemia (AML). Patients and Methods We studied 805 adults (age range, 16 to 60 years) with AML enrolled on German-Austrian AML Study Group (AMLSG) treatment trials AML HD98A and APL HD95 for mutations in exon 4 of IDH1 and IDH2. Patients were also studied for NPM1, FLT3, MLL, and CEBPA mutations. The median follow-up for survival was 6.3 years. Results IDH mutations were found in 129 patients (16.0%) —IDH1 in 61 patients (7.6%), and IDH2

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Wiederin, Jason, Christina Gu, Patricia Jewett, and Anne Hudson Blaes. "Pectoralis muscle wasting during chemotherapy." Journal of Clinical Oncology 38, no. 15_suppl (2020): e24069-e24069. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24069.

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e24069 Background: Chemotherapy is often followed by muscle mass loss which has been associated with frailty. We explored factors associated with change in pectoralis muscle mass after chemotherapy. We hypothesized greater muscle loss with time would be associated with poorer overall survival. Methods: We identified individuals with breast cancer (N = 221), sarcoma (N = 115), and lymphoma (N = 216) who received chemotherapy at the University of Minnesota MHealth Fairview and had CT scans before and after chemotherapy. Right pectoralis muscle area was measured using CORESLICER and indexed to bo

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Remy, Katya, Chase Alston, Elyse Gonzales, et al. "Targeted Reinnervation During Gender-Affirming Mastectomy and Restoration of Sensation." JAMA Network Open 7, no. 11 (2024): e2446782. http://dx.doi.org/10.1001/jamanetworkopen.2024.46782.

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ImportanceDuring gender-affirming mastectomy, nerves are transected, resulting in sensory loss. Nerve preservation using targeted nipple-areola complex (NAC) reinnervation (TNR) may restore sensation.ObjectiveTo determine the quantitative and patient-reported sensory outcomes of TNR.Design, Setting, and ParticipantsProspective matched cohort study of patients undergoing gender-affirming mastectomy from August 2021 to December 2022 at Weill Cornell Medicine and Massachusetts General Hospital. Data were analyzed from January to March 2023.ExposurePatients who underwent TNR and matched patients w

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Brunner, Andrew M., Shuli Li, Amir T. Fathi, et al. "Hematopoietic Cell Transplantation with or without Sorafenib Maintenance for Patients with FLT3-ITD Acute Myeloid Leukemia in CR1." Blood 126, no. 23 (2015): 864. http://dx.doi.org/10.1182/blood.v126.23.864.864.

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Abstract Introduction: Patients with acute myeloid leukemia (AML) with internal tandem duplications in the fms-like tyrosine kinase 3 receptor (FLT3-ITD) are at high risk for relapse despite allogeneic hematopoietic cell transplantation (HCT) in first remission (CR1).We have previously shown sorafenib, an oral FLT3/multikinase inhibitor, to be safe as maintenance therapy after HCT (BBMT 2014;20:2042). We performed a retrospective study to evaluate the impact of sorafenib maintenance on outcomes of adult patients with FLT3-ITD AML undergoing HCT in CR1. Methods: We identified consecutive patien

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Ko, Soohyeon, Hannah Oh, S. V. Subramanian, and Rockli Kim. "Small Area Geographic Estimates of Cardiovascular Disease Risk Factors in India." JAMA Network Open 6, no. 10 (2023): e2337171. http://dx.doi.org/10.1001/jamanetworkopen.2023.37171.

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ImportanceWith an aging population, India is facing a growing burden of cardiovascular diseases (CVDs). Existing programs on CVD risk factors are mostly based on state and district data, which overlook health disparities within macro units.ObjectiveTo quantify and geovisualize the extent of small area variability within districts in CVD risk factors (hypertension, diabetes, and obesity) in India.Design, Setting, and ParticipantsThis cross-sectional study analyzed nationally representative data from the National Family Health Survey 2019-2021, encompassing individuals aged 15 years or older, fo

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Chamseddine, Sarah, Haniah A. Zaheer, John V. Williams, Judith M. Martin, Anne-Marie Rick, and Hui Liu. "1328. Risk Factors for Severe Influenza Outcomes Among Infants Born Between 2011 and 2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S752. http://dx.doi.org/10.1093/ofid/ofab466.1520.

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Abstract Background Influenza in infancy can cause significant morbidity and mortality. This study aimed to characterize influenza outcomes in infants &lt; ορ = 12 months and identify risk factors for severe infection. Methods A retrospective cohort of infants ≤ 12 months born between 2011-2019 who received longitudinal ambulatory and inpatient care within a multi-facility hospital system and had laboratory-confirmed influenza were included. Perinatal, medical and illness characteristics were described. Risk factors for severe influenza (hospitalization, intensive-care unit (ICU) admission

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Mian, A., P. Curtis, C. Henning, et al. "AB0519 LONG-TERM SAFETY OF BELIMUMAB AMONG ADULT PATIENTS WITH SLE: POOLED DATA FROM THREE OPEN-LABEL EXTENSION STUDIES OVER 11+ YEARS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1454–55. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3002.

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BackgroundBelimumab is approved for the treatment of systemic lupus erythematosus (SLE) in >75 countries[1]. Clinical trials and long-term extension (LTE) studies have demonstrated the consistent safety profile of belimumab in patients with SLE receiving standard therapy (ST)[2-4]. A pooled analysis of LTE studies could provide a more robust dataset to explore the long-term safety of belimumab.ObjectivesTo evaluate the long-term safety of belimumab in adult patients with SLE using pooled data from three multicentre, LTE studies.MethodsThis post hoc analysis pooled data from three belimumab

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Duong, Vu H., Michael V. Jaglal, Ling Zhang, et al. "Phase II Pilot Study of Oral Dasatinib in Subjects with Higher Risk Myelodysplastic Syndrome (MDS) Who Failed Conventional Therapy." Blood 118, no. 21 (2011): 1727. http://dx.doi.org/10.1182/blood.v118.21.1727.1727.

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Abstract Abstract 1727 Introduction: Src family kinases (SFKs), in particular Lyn kinase, play a critical role in mediating GM-CSF and G-CSF response in myeloid leukemic cell proliferation. Lyn kinase is constitutively active in AML blasts and MDS megakaryocyte progenitors, and inhibition of Lyn suppresses leukemic cell growth in vitro (Ozawa Y, et. al. Leuk Res 2008). Given dasatinib's broad spectrum of kinase inhibition, we hypothesized that dasatinib treatment could limit blast proliferation in patients with high risk MDS. Methods and Materials: This was a single-center, open-label, 2-stage

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Montalban-Bravo, Guillermo, Xuelin Huang, Elias J. Jabbour, et al. "A Phase II Clinical Trial of Azacitidine and Vorinostat for Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS) with Poor Performance Status, Comorbidities, Other Active Malignancies or Organ Dysfunction Not Eligible for Conventional Clinical Trials." Blood 128, no. 22 (2016): 1999. http://dx.doi.org/10.1182/blood.v128.22.1999.1999.

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Abstract INTRODUCTION: Most clinical trials exclude patients with poor performance, organ dysfunction, and presence of other active malignancies or comorbidities. Although some of these criteria are based on clinical reasoning, patients with such clinical features have dismal expected outcomes and limited therapeutic options and could therefore have a more favorable risk/benefit ratio if treated with a low intensity investigational intervention. The current study was designed to test whether it is feasible to treat patients not eligible for conventional studies in a clinical trial. METHODS: We

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Musicus, Aviva A., Christina A. Roberto, Alyssa J. Moran, Sarah Sorscher, Eva Greenthal, and Eric B. Rimm. "Effect of Front-of-Package Information, Fruit Imagery, and High–Added Sugar Warning Labels on Parent Beverage Choices for Children." JAMA Network Open 5, no. 10 (2022): e2236384. http://dx.doi.org/10.1001/jamanetworkopen.2022.36384.

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ImportanceFruit drinks are widely consumed by young children, and many parents mistakenly believe that these drinks are healthy, potentially due to front-of-package claims and imagery. Research is needed on the influence of this marketing and how labeling regulations could change behavior.ObjectiveTo assess the effects of a front-of-package 100% vitamin C claim, fruit imagery, percentage juice and teaspoons of added sugar disclosures, and high–added sugar warnings on parents’ choices, knowledge, and perceptions of beverages.Design, Setting, and ParticipantsThis randomized clinical trial was co

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Cappellini, Maria Domenica, Amal El-Beshlawy, Antonis Kattamis, et al. "Efficacy and Safety of Deferasirox (Exjade®) in Patients with Transfusion- Dependent Anemias: 1-Year Results from the Large, Prospective, Multicenter EPIC Study." Blood 112, no. 11 (2008): 3875. http://dx.doi.org/10.1182/blood.v112.11.3875.3875.

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Abstract Background: Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy for treating transfusional iron overload. In registration trials, the starting dose was based on baseline liver iron concentration (LIC). The prospective multicenter EPIC trial, the largest ever conducted for an iron chelator, included patients (pts) with a variety of transfusion-dependent anemias and was designed to evaluate the efficacy and safety of fixed starting doses of deferasirox based on transfusion history, with subsequent dose titration based on serum ferritin (SF) trends. On

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Borjas-Howard, Jaime, Wouter FW Bierman, Tjip S. van der Werf, Karina Meijer, and Vladimir Tichelaar. "Incidence of Thrombotic Events in Patients Admitted to a Dedicated Tuberculosis Center in the Netherlands." Blood 124, no. 21 (2014): 2860. http://dx.doi.org/10.1182/blood.v124.21.2860.2860.

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Abstract Introduction Tuberculosis (TB) claims over 1 million deaths per year. Some patients die despite institution of effective chemotherapy. As epidemiological and fundamental research show that acute or chronic inflammatory diseases are a risk factor for thrombotic events, TB-patients may especially be at high risk for venous thrombotic events (VTE) as TB is an infectious disease that can be seen as an acute-on-chronic inflammatory process and is often associated with a double/triple infectious burden caused by HIV or hepatitis. Consequently, VTE may explain a part of TB related mortality,

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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De Greef, Georgine E., Eric Braakman, Wendimagegn G. Alemayehu, et al. "Lymphocyte and Hematopoietic Stem and Progenitor Cell (HSPC) Subsets Mobilized By Either Plerixafor or G-GCSF: A Retrospective Comparison of Grafts Harvested in Healthy Allogeneic Stem Cell Donors." Blood 124, no. 21 (2014): 2451. http://dx.doi.org/10.1182/blood.v124.21.2451.2451.

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Abstract Plerixafor (PXF) is a bicyclam molecule, which acts as a reversible inhibitor of SDF-1 binding to CXCR4. A single injection results in immediate release of CD34+ cells into the peripheral blood. Sofar, PXF has been used for stem cell mobilization only in a limited number of allogeneic donors (Devine et al. Blood.2008;112(4):990) The currently ongoing randomized phase 2 Hovon -107 study of the Dutch hemato-oncology group HOVON (www.hovon.nl) aims to compare the feasibility of intravenous (iv) versus subcutaneous (sc) PXF (Genzyme Europe BV) 320 µg/kg subcutaneously (sc) 9 hours before

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AYANKOSO, Micheal Taiwo, Damilola Miracle OLUWAGBAMILA, and Olugbenga Samson ABE. "EFFECTS OF ACTIVATED CHARCOAL ON LIVESTOCK PRODUCTION: A REVIEW." Slovak Journal of Animal Science 56, no. 01 (2023): 46–60. http://dx.doi.org/10.36547/sjas.791.

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Aerts, R. (1997). Nitrogen partitioning between resorption and decomposition pathways: a trade-off between nitrogen use efficiency and litter decomposability? Oikos, 80(3), 603−406. Ahmedna, M., Marshall, W. E. & Rao, R. O. (2000). Granular Activated Carbons from Agricultural By-Products: Preparation, Properties, and Application in Cane Sugar Refining. LSU AgCenter: Bulletin Number 869. Albiker, D. & Zweifel, R. (2019). Pflanzenkohle im Futter oder in der Einstreu und ihre Wirkung auf die Stickstoffretention und Leistung von Broilern. Wissenschaftstagung Ökologischer Landbau. Kassel: S

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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Wang, Jianxiang, Weijun Fu, Soo-Mee Bang, et al. "Progression-Free Survival Outcomes By Response Status for Bortezomib, Melphalan, and Prednisone with or without Daratumumab in Newly Diagnosed Multiple Myeloma: Pooled Subgroup Analysis of Octans and Alcyone." Blood 138, Supplement 1 (2021): 1648. http://dx.doi.org/10.1182/blood-2021-148937.

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Abstract Introduction: Daratumumab is a human IgGκ monoclonal antibody that targets CD38 with a direct on-tumor and immunomodulatory mechanism of action. In the primary analysis (median follow-up, 16.5 months) of the global phase 3 ALCYONE trial, daratumumab in combination with bortezomib, melphalan, and prednisone (D-VMP) significantly improved progression-free survival (PFS) versus VMP alone in patients with newly diagnosed multiple myeloma (NDMM) who were ineligible for transplant (median PFS, not reached vs 18.1 months; hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.38-0.65; P&am

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Kim, Jinyoung, and Geahwan Jin. "The Analysis of Correction Effect of Motion Artifacts in PET Images Using Respiratory Gating System." Journal of Medical Imaging 5, no. 1 (2022): 1–20. http://dx.doi.org/10.31916/sjmi2022-01-01.

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PET is used effectively for biochemical or pathological phenomena, disease diagnosis, prognosis determination after treatment, and treatment planning because it can quantify physiological indicators in the human body by imaging the distribution of various biochemical substances. However, since respiratory motion artifacts may occur due to the movement of the diaphragm due to breathing, we would like to evaluate the practical effect by using the a device-less data-driven gated technique called Motion Free (DDG) with the phase-based gating correction method called Q.static scan mode. In this stu

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Polizzotto, Mark N., Irini Sereti, Thomas S. Uldrick, et al. "Pomalidomide Induces Expansion of Activated and Central Memory CD4+ and CD8+ T Cells in Vivo in Patients with and without HIV Infection." Blood 124, no. 21 (2014): 4128. http://dx.doi.org/10.1182/blood.v124.21.4128.4128.

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Abstract Background: Despite antiretroviral therapy (ART), people with HIV continue to exhibit immune deficits including failure to fully reconstitute CD4 T cell numbers and function, resulting in increased risks of tumors and infections and reduced response to vaccination. Pomalidomide, a derivative of thalidomide (IMID), has immunomodulatory properties that may be beneficial in this setting. We explored its impact on lymphocyte number and activation in patients with and without HIV treated within a prospective clinical trial for Kaposi sarcoma. Methods: Patients received pomalidomide 5mg ora

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Malte, Carol A., Patrick L. Dulin, John S. Baer, et al. "Usability and Acceptability of a Mobile App for the Self-Management of Alcohol Misuse Among Veterans (Step Away): Pilot Cohort Study." JMIR mHealth and uHealth 9, no. 4 (2021): e25927. http://dx.doi.org/10.2196/25927.

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Background Alcohol misuse is common among Operation Enduring Freedom and Operation Iraqi Freedom veterans, yet barriers limit treatment participation. Mobile apps hold promise as means to deliver alcohol interventions to veterans who prefer to remain anonymous, have little time for conventional treatments, or live too far away to attend treatment in person. Objective This pilot study evaluated the usability and acceptability of Step Away, a mobile app designed to reduce alcohol-related risks, and explored pre-post changes on alcohol use, psychological distress, and quality of life. Methods Thi

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Hou, Jian, Weijun Fu, Soo-Mee Bang, et al. "Daratumumab, Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma: Pooled Analysis of Octans and Alcyone." Blood 138, Supplement 1 (2021): 1661. http://dx.doi.org/10.1182/blood-2021-146974.

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Abstract Introduction: Daratumumab is a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action. In the global phase 3 ALCYONE trial, the addition of daratumumab to bortezomib, melphalan, and prednisone (D-VMP) resulted in improved outcomes over bortezomib, melphalan, and prednisone (VMP) alone in transplant-ineligible patients (pts) with newly diagnosed multiple myeloma (NDMM). At a median follow-up of 16.5 months, the median progression-free survival (PFS) was not reached (NR) for the D-VMP group versus 18.1 months for the VMP group (haza

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Killaspy, Helen, Stefan Priebe, Michael King, et al. "Supported accommodation for people with mental health problems: the QuEST research programme with feasibility RCT." Programme Grants for Applied Research 7, no. 7 (2019): 1–82. http://dx.doi.org/10.3310/pgfar07070.

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Background Across England, around 60,000 people live in mental health supported accommodation: residential care, supported housing and floating outreach. Residential care and supported housing provide on-site support (residential care provides the highest level), whereas floating outreach staff visit people living in their own tenancies. Despite their abundance, little is known about the quality and outcomes of these services. Objectives The aim was to assess the quality, costs and effectiveness of mental health supported accommodation services in England. The objectives were (1) to adapt the

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McAnally, Brooke E., Dallas R. Soffa, Molly S. Smith, et al. "PSI-12 Characterization of Boar Reproductive Tract Microbiome Prior to Puberty Attainment." Journal of Animal Science 101, Supplement_3 (2023): 365–66. http://dx.doi.org/10.1093/jas/skad281.434.

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Abstract A large portion of microbiome research has focused on characterization of the gastrointestinal tract and female reproductive tract. However, minimal research has focused on establishing the bacterial community in other organs, specifically male reproductive tissues and gonads. Characterization of these microbiomes in early life could be an indicator of future semen microbiome composition and subsequent fertility status. The aim of this study was to characterize the bacterial communities of various male reproductive tissues including the testes, epididymis, seminal vesicles, prostate,

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Chen, Robert W., Jessie Hou, Indu Nair, et al. "Inhibition of MDR1 Overcomes Brentuximab Vedotin Resistance in Hodgkin Lymphoma Cell Line Model and Is Synergistic with Brentuximab Vedotin in Mouse Xenograft Model." Blood 128, no. 22 (2016): 752. http://dx.doi.org/10.1182/blood.v128.22.752.752.

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Abstract Background: Classical Hodgkin lymphoma (HL) expresses surface CD30. Brentuximab vedotin (BV) is an antibody-drug conjugate that selectively delivers a potent cytotoxic agent, monomethyl auristatin E (MMAE), specifically to cells expressing surface CD30. Although BV elicits a high response rate (75%) in HL, patients who do not achieve complete response (CR) will eventually develop resistance to BV. We have developed 2 BV-resistant HL cell models and shown that resistance to BV is due to MDR1 upregulation rather than downregulation of surface CD30. MDR1 upregulation leads to increased d

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Haferlach, Torsten, Ulrike Bacher, Tamara Alpermann, et al. "Further Insights Into The Molecular Landscape Of De Novo Acute Myeloid Leukemia (AML) Investigating 1,291 Patients." Blood 122, no. 21 (2013): 607. http://dx.doi.org/10.1182/blood.v122.21.607.607.

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Abstract Background The Cancer Genome Atlas Research Network (TCGA) published a hallmark sequencing study on molecular mutations in 200 fully characterized adult de novo AML (NEJM 2013). According to their data AML harbor in average 13 mutations in the coding region of the genome of which 5 are in genes known to be recurrently mutated in AML. Further, detailed data on co-occurrence and mutual exclusiveness of molecular mutations was presented. However, given the heterogeneity of AML a cohort of 200 AML might not be fully representative. Aims 1. Compare the published mutation frequency to our c

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Maffini, Enrico, Myriam Labopin, Didier Blaise, et al. "CD34+ Cell Dose Effects on Clinical Outcomes of Patients with Acute Myeloid Leukemia after T-Replete Haploidentical Allogeneic Hematopoietic Stemcell Transplantation Using Peripheral Blood Stem Cells. a Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)." Blood 134, Supplement_1 (2019): 4586. http://dx.doi.org/10.1182/blood-2019-123987.

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The absolute number of infused CD34+ donor cells represents a critical step towards the achievement of a meaningful marrow engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). Previous observations have reported controversial conclusions regarding the impact of CD34+ donor cell doses and post-transplant clinical end-points. The vast majority of analysis conducted so far have considered myeloablative and reduced-intensity conditioning allogeneic HSCT setting, with HLA-matched sibling and/or unrelated donors. The T-cell replete haploidentical setting has not been extensiv

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Lopez Salazar, Javier, Laura A. Ramirez Tirado, Nora Gomez Contreras, Oscar Arrieta, Dolores Gallardo, and Gabriela Cesarman-Maus. "Leukocytosis, but Not Thrombocytosis, May Constitute a Prothrombotic Pathway in Women with Ovarian Cancer: A Cohort Study." Blood 132, Supplement 1 (2018): 1228. http://dx.doi.org/10.1182/blood-2018-99-120193.

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Abstract Venous thromboembolism (VTE) occurs at a higher rate in cancer patients and is frequently associated with well-known prothrombotic risk factors such as prolonged bed rest, central venous catheters, diverse oncological treatments and invasive procedures. Patients may share one or more risk factors. In addition, there seem to be tumor-driven prothrombotic pathways. Thus different tumors may promote activation of coagulation either directly through the expression of procoagulant molecules such as tissue factor or indirectly through the secretion of factors that in turn induce thrombocyto

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Mease, P. J., E. Soriano, S. D. Chakravarty, et al. "POS1030 PAIN RESPONSE IN PSORIATIC ARTHRITIS PATIENTS TREATED WITH GUSELKUMAB IS DRIVEN PREDOMINANTLY BY INFLAMMATION-INDEPENDENT EFFECTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 828.1–828. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1384.

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BackgroundAlthough reducing inflammation has been associated with pain improvement, the two do not always correlate. Recent studies have suggested that, in addition to its role in inflammation pathogenesis, IL-23 may be involved in pain regulation in a lymphocyte-independent manner1. Guselkumab (GUS), a fully human monoclonal antibody that selectively inhibits IL-23, has demonstrated safety and efficacy in treating multiple domains of active PsA in the DISCOVER-1&2 (D1&D2) trials2,3.ObjectivesTo quantify the role of reducing inflammation on the observed relationship between GUS and pai

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Rossi, Davide, Michaela Cerri, Clara Deambrogi, et al. "The Prognostic Value of TP53 Mutations in Chronic Lymphocytic Leukemia (CLL) Is Independent of del17p13: Implications for Overall Survival and Chemorefractoriness." Blood 112, no. 11 (2008): 3137. http://dx.doi.org/10.1182/blood.v112.11.3137.3137.

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Abstract CLL harboring del17p13 displays a dismal prognosis and a high risk of chemorefractoriness. We tested whether TP53 inactivation through mutation harbors the same prognostic role as del17p13 on 308 consecutive CLL. TP53 mutation status was assessed at diagnosis by direct sequencing of TP53 exons 2–10. Thirty-two TP53 mutations were observed in 31/308 (10.0%) CLL. Among 26 missense mutations, the median residual transactivation activity compared to germline TP53 was 8.9% (25th–75th percentile: 0.6–13.0%), and was ≤20% in 22/26 (84.6%) mutations. All microdeletions and microinsertions (4/

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Dimopoulos, Meletios A., Maria-Victoria Mateos, Michele Cavo, et al. "One-Year Update of a Phase 3 Randomized Study of Daratumumab Plus Bortezomib, Melphalan, and Prednisone (D-VMP) Versus Bortezomib, Melphalan, and Prednisone (VMP) in Patients (Pts) with Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM): Alcyone." Blood 132, Supplement 1 (2018): 156. http://dx.doi.org/10.1182/blood-2018-156.

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Abstract Introduction Daratumumab (DARA) is a human IgGκ anti-CD38 monoclonal antibody with a direct on-tumor and immunomodulatory mechanism of action. In combination with standard of care (SOC) regimens, DARA has consistently demonstrated a doubling of complete response (CR) rates, tripling of minimal residual disease (MRD)-negative rates, and reduction in the risk of progression or death by ≥50% vs SOC alone in relapsed/refractory MM and NDMM pts. In the prespecified interim analysis of ALCYONE, a phase 3 study of D-VMP versus VMP in transplant ineligible NDMM (Mateos MV, N Engl J Med 2018.

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