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Journal articles on the topic '8-naphthyridines'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

K., VIJAYENDBR REDDY, MOGILAIAH K, and SREENIVASULU B. "Substituted I ,8-Naphthyridines. Part-Ill. Synthesis and Biological Activity of some I ,8-Naphthyridine Derivatives." Journal of Indian Chemical Society Vol. 63, Apr 1986 (1986): 443–46. https://doi.org/10.5281/zenodo.6255511.

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Department of Chemistry, Kakatiya University, Warangal-506 009 <em>Manuscript received 16 August 1985, accepted 24 December 1985</em> Substituted I,8-Naphthyridines. Part-Ill. Synthesis and Biological Activity of some I ,8-Naphthyridine Derivatives.          

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2

K., RAJENDAR REDDY, MOGILAIAH K., and SREENlVASULU B. "Substituted-1 ,8-naphthyridines. Part-lV. Synthesis of 1-Methyl-N-aryl-1,8-naphthyridine- 3-carboxamides." Journal of Indian Chemical Society Vol. 64, Mar 1987 (1987): 193–94. https://doi.org/10.5281/zenodo.6221584.

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Department of Chemistry, Kakatiya University, Warangal-506 009 <em>Manuscript received 23 September 1986, acctepted 22 January 1981</em> Substituted-1 ,8-naphthyridines. Part-lV. Synthesis of 1-Methyl-N-aryl-1,8-naphthyridine- 3-carboxamides  

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3

Chen, QP, LW Deady, and MF Mackay. "A Comparison of Chemical Reactivity in Some Benzo[b]Naphthyridines (Azaacridines)." Australian Journal of Chemistry 46, no. 12 (1993): 1909. http://dx.doi.org/10.1071/ch9931909.

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Some comparisons between four series of benzo [b][1,x] naphthyridines (x=5-8) have been made. Bromination in acetic acid gave almost exclusive reaction β to the nitrogen in the outer pyrido ring. Basic silver oxide oxidation of the centre ring occurred in the order x = 6 > 8 > 7 > 5. Methylation occurred on the pyrido nitrogen, the relative nucleophilicities paralleling those of the corresponding naphthyridines . One methiodide (x = 6) underwent an interesting dimerization in solution and the structure of the product was determined by X-ray crystallography.

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4

Mogilaiah, Kaleru, Janapatla Uma Rani, and Boda Sakram. "Synthesis of 1,2,4-triazolo[4,3-a][1,8]Naphthyridines using Chloranil under Microwave Irradiation." Journal of Chemical Research 2005, no. 8 (2005): 516–19. http://dx.doi.org/10.3184/030823405774663309.

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A simple and highly efficient procedure has been described for the synthesis of 1-aryl-4-[p-bromophenyl)-1,2, 4-triazolo[4,3-a][1,8]naphthyridines (8) by the oxidation of the corresponding aryl aldehyde 3-(p-bromophenyl)-1, 8-naphthyridin-2-ylhydrazones (7) with chloranil under microwave irradiation. The products are obtained in good yields and in a state of high purity.

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5

K., RAJENDAR REDDY, MOGILAIAH K., and SREENIVASULU B. "Condensed 1,8-Naphthyridines. Part-VI. Synthesis of 8-Aryl-8H-naphtho [1',2' : 5,6]pyrano[4,3-b][1,8]naphthyridines." Journal of Indian Chemical Society Vol. 63, Nov 1986 (1986): 984–85. https://doi.org/10.5281/zenodo.6296706.

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Department of Chemistry, Kakatiya University, Warangal-506 009 <em>Manuscript received 3 December 1985, accepted 5 September 1986</em> The condensation of 2-aminonicotinaldehyde (1) with substituted-2-hydrory-1- naphthyl styryl ketones (2) in the presence of glacial acetic acid containing a catalytic amount of concentrated sulphuric acid affords the corresponding 8-aryl-8<em>H</em>-naphthot[1'2' : 5,6]pyrano[4,3-<em>b]</em>[1,8]naphthyridines (3). Structures of the products have been established on the basis of elemental analyses, and ir, pmr and mass spectral data. The compounds

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6

Jiang, Xinglong, Guang-Pei Chen, Kapa Prasad, Oljan Repič, and Thomas J. Blacklock. "A general synthesis of 8-hydroxy-6-substituted-1,7-naphthyridines." Journal of Heterocyclic Chemistry 43, no. 6 (2006): 1725–28. http://dx.doi.org/10.1002/jhet.5570430648.

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7

Kingsford-Adaboh, R., S. Kashino, K. Sasaki, A. S. S. Rouf, and T. Hirota. "5-Amino-8-methyl-1,2-dihydrothieno(and furo)[2,3-h][1,6]naphthyridines." Acta Crystallographica Section C Crystal Structure Communications 52, no. 2 (1996): 372–75. http://dx.doi.org/10.1107/s0108270195013035.

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8

Konovalenko, Artem, Oleh Shablykin, Olga Shablykina, Andrii Kozytskyi, and Volodymyr Brovarets. "Convenient and versatile method of 8-amino-6-(2-R-thiazol-4-yl)-1,7-naphthyridines synthesis." Current Chemistry Letters 13, no. 1 (2024): 163–72. http://dx.doi.org/10.5267/j.ccl.2023.7.004.

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On the base of 3-formylpicolinic acid by two successive heterocyclizations (the formation of a pyrone fragment by the cyclization of chloroacetone with the carboxyl and formyl groups; and the construction of the thiazole cycle through the bromination of the acetyl fragment and following interaction with thioamides), 6-(2-(phenyl/thiophen-2-yl)thiazole-4-yl)-8H-pyrano[3,4-b]pyridin-8-ones were obtained; and then the pyrone fragment was converted to pyridone by the action of ammonia under high pressure. When such 6-(2-R-thiazol-4-yl)-1,7-naphthyridin-8(7H)-ones reacted with triflic anhydride, O-

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9

Kulikova, Larisa N., Ghulam Reza Raesi, Daria D. Levickaya, et al. "Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors." Molecules 28, no. 4 (2023): 1662. http://dx.doi.org/10.3390/molecules28041662.

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In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (5), 1-indol-3-yl (8), and azocino[4,5-b]quinoline (10) derivatives, were synthesized and characterized herein for the first time. Among the newly synthesized derivatives, 5c–h proved to be MAO B inhibitors with potency in the low micromolar range. In particular, the 1-(2-(4-fluorophenyl)ethynyl) analog 5g achieved an IC50 of 1.35 μM, a value close to that of the well-known MAO B inhibitor pargyline.

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10

Ravikumar Naik, Tangali R., Halehatty S. Bhojya Naik, M. Raghavendra, P. J. Bindu, and Kittappa M. Mahadevan. "Synthesis of novel 1,5-benzothiazepine[7,6-b]-1, 8-naphthyridines under microwave irradiation via Mannich condensation." Journal of Sulfur Chemistry 28, no. 6 (2007): 589–95. http://dx.doi.org/10.1080/17415990701625050.

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11

Badawneh, Muwaffag, and Jalal Aljamal. "SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PIPERIDINE AND MORPHOLINE 1, 8 NAPHTHYRIDINE ANALOGUES." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 12 (2016): 252. http://dx.doi.org/10.22159/ijpps.2016v8i12.13503.

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<p><strong>Objective: </strong>The search for new, potentially useful antimycobacterial agents. In continuation with our previous screening for the discovery of novel drugs for tuberculosis, a new series of 1,8-naphthyridines derivatives were synthesized and evaluated <em>in vitro </em>for antimycobacterial activity against <em>Mycobacterium tuberculosis </em>H37Rv.</p><p><strong>Methods: </strong>Several 4-morpholinomethyl-1.8-naphthyridine derivatives have been synthesized in excellent yields. The synthesized compounds were ch

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12

Zhuang, Linghang, John S. Wai, Mark W. Embrey, et al. "Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells." Journal of Medicinal Chemistry 46, no. 4 (2003): 453–56. http://dx.doi.org/10.1021/jm025553u.

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13

KANCHAN, AGARWAL. "Synthesis and Pharmacological Evaluation of some New Substituted-1 ,8-naphthyridines and Substitutedquinazolin-4-ones as Hypotensive and CNS Active Agents." Journal of Indian Chemical Society Vol. 68, Feb 1991 (1991): 85–87. https://doi.org/10.5281/zenodo.5954640.

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Department of Chemistry, Lucknow University, Lucknow·226 007 <em>Manuscript received 31 May 1990, revised 27 November 1990, accepted 6 December 1990</em> <em>p</em>-(3 -Aroy1-2-pheny1-1,8-naphthyridinyl)methoxyacetylhydrazine on reaction with isatin converted into 5 and with 2-(3<em>'</em>-nitro-4<em>'</em>-chlorophenyl)quinazolin-4-one converted into 10. Both 5 and 10 on Mannich reaction gave the desired products (7a —j and 11a — f). The compounds were evaluated for central nervous system (CNS) and hypotensive activity.

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14

van der Plas, H. C., M. Wózniak, and A. van Veldhuizen. "Ring transformations and tele-aminations in the reaction of 2-halogeno- and 8-halogeno-1,7-naphthyridines by potassium amide in liquid ammonia." Recueil des Travaux Chimiques des Pays-Bas 96, no. 6 (2010): 151–55. http://dx.doi.org/10.1002/recl.19770960602.

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15

Thomas, Michael G., Manu De Rycker, Richard J. Wall, et al. "Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity." Journal of Medicinal Chemistry 63, no. 17 (2020): 9523–39. http://dx.doi.org/10.1021/acs.jmedchem.0c00705.

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16

Bacqué, Eric, Myriem El Qacemi, and Samir Z. Zard. "Tin-Free Radical Cyclizations for the Synthesis of 7-Azaoxindoles, 7-Azaindolines, Tetrahydro[1,8]naphthyridines, and Tetrahydro-5H-pyrido[2,3-b]azepin-8-ones." Organic Letters 6, no. 21 (2004): 3671–74. http://dx.doi.org/10.1021/ol0489649.

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17

Guajardo, Juana, Andrés Ibañez, Veronique Guerchais, Andrés Vega, Sergio Moya, and Pedro Aguirre. "Ruthenium(II)–carbonyl complexes containing two N-monodentate 1,8-naphthyridine ligands: active catalysis in transfer hydrogenation reactions." Acta Crystallographica Section C Structural Chemistry 74, no. 11 (2018): 1547–52. http://dx.doi.org/10.1107/s2053229618014201.

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The reaction of 2-aminonicotinaldehyde with 2- or 4-methoxyacetophenone in basic media leads to the new ligands 2-(4-methoxyphenyl)-1,8-naphthyridine and 2-(2-methoxyphenyl)-1,8-naphthyridine, respectively, in high yield. The reaction of these naphthyridine derivatives with [RuCl2(CO)2] n leads to the respective complexes cis-dicarbonyldichloridobis[2-(4-methoxyphenyl)-1,8-naphthyridine-κN 8]ruthenium(II) and cis-dicarbonyldichloridobis[2-(2-methoxyphenyl)-1,8-naphthyridine-κN 8]ruthenium(II), both [RuCl2(C15H12N2O)2(CO)2], in good yield. Both ruthenium(II) complexes display a slightly distort

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18

Chen, Chen, Kun-Yan Wang, Jin-Fang Liu, Dan-Feng Wang, and Hong-Jun Zhu. "4-Diphenylphosphanyl-8-methyl-1,5-naphthyridine." Acta Crystallographica Section E Structure Reports Online 69, no. 6 (2013): o928. http://dx.doi.org/10.1107/s1600536813013196.

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19

Gurjar, Vinod Kumar. "Synthesis and ADMET Study of Some 1, 8-Naphthyidine and Quinoline 3-Carboxylic Acid Derivatives." International Journal for Research in Applied Science and Engineering Technology 9, no. 11 (2021): 1932–38. http://dx.doi.org/10.22214/ijraset.2021.39142.

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Abstract: The extremely drug resistant may be a worldwide public ill health in recent years. Molecules with newer targets and an alternate mechanism of action is an urgent requirement of improvement of latest drugs. The utilization of heterocyclic compounds has been increased dramatically over the last 70 years due to their wide selection of technical applications and their favorable environmental and toxicological properties The 1,8-naphthyridine and quinoline 3-carboxylic acid derivatives that we'll manufacture during this method will change the potency and specificity of fluoroquinolones. T

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20

Utkina, Natalia K., and Vladimir A. Denisenko. "N-Demethylaaptanone, A new Congener of Aaptamine Alkaloids from the Vietnamese Marine Sponge Aaptos aaptos." Natural Product Communications 11, no. 9 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100916.

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A new compound, N-demethylaaptanone (5), having an oxygenated 1,6-naphthyridine core, has been isolated from the Vietnamese marine sponge Aaptos aaptos, along with the known metabolites, aaptamine (1), isoaaptamine (2), 9-demethylaaptamine (3), and aaptanone (4). The structure of N-demethylaaptanone was determined as 9-hydroxy-8-methoxy-4 H-benzo[ de][1,6]-naphthyridine-5,6-dione from spectroscopic data.

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21

Rádl, Stanislav, and Pavel Hradil. "Synthesis of some 1-alkyl-1,4-dihydro-4-oxo-1,7-naphthyridine-3-carboxylic acids." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2420–29. http://dx.doi.org/10.1135/cccc19912420.

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Reaction of substituted 2-aminopyridines IIIa, IIIb, IIIe, and IIIf with ethyl ethoxymethylene malonate provided corresponding pyridylaminomethylenemalonates Va-Vd, respectively. Thermal cyclization of Va, Vc, and Vd yielded substituted ethyl 4-hydroxy-1,7-naphthyridine-3-carboxylates VIa, VIc, and VId. Compounds VIc and VId treated with morpholine gave 8-morpholino derivatives VIe and VIf. These compounds were ethylated to mixtures of N-ethylated (VIIa, VIIb) and O-ethylated products (VIIIa, VIIIb). Compound VIIIb was also prepared from ethyl 4-chloro-6-fluoro-8-morpholino-1,7-naphthyridine-3

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22

Raghuraj, Parihar, Meena Mukesh, Kumar Meena Dinesh, and Kishore Sharma Brij. "CP-MLR/PLS directed quantitative structure-activity relationship study on the CDK8 inhibitory activity: The derivatives of naphthyridine and isoquinoline." World Journal of Biology Pharmacy and Health Sciences 12, no. 3 (2022): 384–400. https://doi.org/10.5281/zenodo.7643051.

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The CDK8 and 7dF3 inhibition activity of naphthyridine and isoquinoline derivatives have been quantitatively analyzed in terms of Dragon descriptors. The statistically validated quantitative structure-activity relationship (QSAR) models provided rationales to explain the inhibition activities of these congeners. The descriptors identified through CP-MLR analysis for the CDK8 inhibitory activity have highlighted the role of sum of the topological distances between N..N (T(N..N)), distance/detour ring index of order 6 (D/Dr06), aromatic ratio (ARR), number of double bonds (nDB), number of 6-memb

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23

Araújo-Neto, José B. de, Maria M. C. da Silva, Cícera D. de M. Oliveira-Tintino, et al. "Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains." Molecules 26, no. 23 (2021): 7400. http://dx.doi.org/10.3390/molecules26237400.

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The search for new antibacterial agents has become urgent due to the exponential growth of bacterial resistance to antibiotics. Nitrogen-containing heterocycles such as 1,8-naphthyridine derivatives have been shown to have excellent antimicrobial properties. Therefore, the purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H

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24

Shivhare, Km Neha, Anushree Srivastava, and Ibadur Rahman Siddiqui. "Catalyst-Free Glycerol Promoted Green Synthesis of 2-amino-1,8- naphthyridine -3-carbonitriles and 2-amino-3-quinolinecarbonitriles." Current Green Chemistry 6, no. 1 (2019): 62–68. http://dx.doi.org/10.2174/2452273203666190114145322.

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We describe herein the use of glycerol as an efficient and sustainable approach for the synthesis of 2-amino-1, 8-naphthyridine-3-carbonitriles and 2-amino-3-quinolinecarbonitriles. The catalyst- free reactions occur straightforwardly using biodegradable and non-hazardous solvent. It is a strategy to address mounting environmental concerns with current approach includes the use of environmentally benign solvent, simple workup procedure, economic viability, shorter reaction time and providing good to excellent yield.

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25

Chinnakali, K., H. K. Fun, I. A. Razak, P. Murugan, and V. T. Ramakrishnan. "5-Amino-2,4-diphenyl-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." Acta Crystallographica Section C Crystal Structure Communications 54, no. 6 (1998): 781–83. http://dx.doi.org/10.1107/s0108270197019574.

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26

Ferrarini, Pier Luigi, Claudio Mori, Vincenzo Calderone, et al. "ChemInform Abstract: Synthesis of 1,8-Naphthyridine Derivatives: Potential Antihypertensive Agents. Part 8." ChemInform 30, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199948162.

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27

Oanh, Nguyen Thi Tu, To Hai Tung, Cao Thi Hue, Le Nguyen Thanh, Do Thi Thao, and Nguyen Thi Minh Hang. "Two New Alkaloids from Polyalthia nemoralis." Natural Product Communications 12, no. 7 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200706.

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A new azaoxoaporphine alkaloid, 8,9-dimethoxysampangine (1), and a new naphthyridine alkaloid, 7-methoxy-8-hydroxyeupolauridine (2), along with two known azaoxoaporphine alkaloids, sampangine (3) and 9-methoxysampangine (4), were isolated from the EtOAc extract of the barks of Polyalthia nemoralis. Their structures were established on the basis of spectral evidences. Compound 1 exhibited significant cytotoxicity against KB, MCF7, LU-1, HepG2, LNCap, SW626 and SW480 cancer cell lines with IC50 values in the range of 5.06±0.04-7.61±0.06 μM.

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28

Barlin, GB, and W. Tan. "Potential Antimalarials. III. N4-Substituted 7-Bromo-1,5-naphthyridin-4-amines." Australian Journal of Chemistry 38, no. 3 (1985): 459. http://dx.doi.org/10.1071/ch9850459.

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A series of new N4-substituted 7-bromo-1,5-naphthyridin-4-amines has been prepared from nicotinic acid through 3-bromo-8-chloro- 1,5- naphthyridine by nucleophilic replacement of the 8-chloro substituent with appropriate amines. Several of these compounds, namely 7-bromo-N- (4′-diethylamino-1′-methylbutyl)-1,5-naphthy-ridin-4-amine (′5-azabromoquine'), 4-(7′-bromo-1′,5′-naphthyridin-4′-ylamino)-2-(diethylamino-methyl)phenol and 7-bromo-N-(2′-diethylaminoethyl)-1,5- naphthyridin-4-amine showed significant antimalarial acivity. Apparent cures were effected when these test chemicals were injected

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29

Sandhya, Gandra, and Garepalli Ganga Sravanthi. "Microwave assisted synthesis of 1, 3, 5-triazine containing [1, 8]naphthyridine derivatives." Asian Journal of Research in Chemistry 11, no. 1 (2018): 109. http://dx.doi.org/10.5958/0974-4150.2018.00022.6.

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30

Wang, Dao-Lin, Dan Wu, Wei Zhao, Yong-Yang Wang, and Jian-Ying Wu. "An efficient synthesis of benzo[b]benzofurano[2,3-e]-[1,6]naphthyridine-8-ones." Chinese Chemical Letters 26, no. 2 (2015): 251–54. http://dx.doi.org/10.1016/j.cclet.2014.11.005.

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31

Gurjar, Vinod Kumar, and Dilipkumar Pal. "RECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8-NAPHTHYRIDINE DERIVATIVES: A REVIEW." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 8 (2018): 1. http://dx.doi.org/10.22159/ijpps.2018v10i8.27006.

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The 1,8-naphthyridine derivatives have gained special attention from researchers nowadays on account of their demonstrating a variety of interesting biological activities. A wide range of biological activities establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anti-inflammatory, anticancer, antihypertensive and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer’s disease and depression. In addition, these

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32

Md, Kadeer, Dr Ramakanth Pagadala, Dr Venkatesan Kasi, and Dr Ramesh Domala. "Synthesis of 1, 8-Naphthyridine Derivatives using Biodegradable Starch Sulfuric Acid as Heterogeneous Catalyst." CVR Journal of Science & Technology 20, no. 1 (2021): 151–55. http://dx.doi.org/10.32377/cvrjst2024.

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33

Sabatini, Stefano, Violetta Cecchetti, Oriana Tabarrini, and Arnaldo Fravolini. "8-Methyl-7-substituted-1,6-naphthyridine-3-carboxylic acids as New 6-desfluoroquinolone antibacterials." Journal of Heterocyclic Chemistry 36, no. 4 (1999): 953–57. http://dx.doi.org/10.1002/jhet.5570360422.

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34

Nandha Kumar, R., T. Suresh, and P. S. Mohan. "A convenient one-pot synthesis of benzopyrimido[1,8]naphthyridines by Knoevenagel condensation." Chemistry of Heterocyclic Compounds 40, no. 11 (2004): 1490–92. http://dx.doi.org/10.1007/s10593-005-0077-8.

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35

Refat, Hala M., and Khaled S. Mohamed. "Efficient and convenient synthesis of pyrido [2,1-b]benzothiazole, pyrimidopyrido[2,1-b]benzothiazole and benzothiazolo[3,2-a][1,8]naphthyridine derivatives." Heterocyclic Communications 21, no. 4 (2015): 219–24. http://dx.doi.org/10.1515/hc-2015-0018.

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AbstractNew 3-aryl-pyrido[2,1-b][1,3]benzothiazole derivatives 2a–e were synthesized in excellent yields via the reaction of benzothiazoleacetonitrile (1) with different aromatic aldehydes. The treatment of 2-(benzo[d]thiazol-2-yl)-3-(pyridin-4-yl)acrylonitrile (6) with malononitrile afforded 1-amino-3-(pyridin-4-yl)-3H-pyrido[2,1-b][1,3]benzothiazole-2,4-dicarbonitrile (7), which was allowed to react with a variety of reagents to provide pyrimido[5′,4′:5,6]pyrido[2,1-b][1,3]benzothiazole 8, 9 and [1,3]benzothiazolo[3,2-a][1,8]naphthyridine 10, 15 derivatives. All synthesized products were con

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36

Sankaranarayanan, R., S. Shanmuga Sundara Raj, D. Velmurugan, H. K. Fun, V. Raghukumar, and V. T. Ramakrishnan. "5-Amino-4-(4-methoxyphenyl)-2-phenyl-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." Acta Crystallographica Section C Crystal Structure Communications 55, no. 10 (1999): 1670–72. http://dx.doi.org/10.1107/s0108270199007829.

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37

Govindasamy, L., D. Velmurugan, V. Raghukumar, Il-Hawn Suh, and V. T. Ramakrishnan. "5-Amino-4-(4-diethylaminophenyl)-2-phenyl-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." Acta Crystallographica Section C Crystal Structure Communications 56, no. 1 (2000): 80–81. http://dx.doi.org/10.1107/s0108270199009257.

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38

Wang, Dao-Lin, Dan Wu, Wei Zhao, Yong-Yang Wang, and Jian-Ying Wu. "ChemInform Abstract: An Efficient Synthesis of Benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-ones." ChemInform 46, no. 28 (2015): no. http://dx.doi.org/10.1002/chin.201528216.

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39

Mastalarz, Henryk, Ryszard Jasztold-Howorko, Felicja Rulko, Alain Croisy, and Daniele Carrez. "Synthesis and Cytostatic Properties of Some 6H-Indolo[2, 3-b][1, 8]naphthyridine Derivatives." Archiv der Pharmazie 337, no. 8 (2004): 434–39. http://dx.doi.org/10.1002/ardp.200200696.

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YOSHIDA, Atomi, and Reimei MOROI. "Crystal structure of 5-ethyl-5,8-dihydro-8-oxofuro(3,2-b)(1,8)naphthyridine-7-carboxylic acid." Analytical Sciences 7, no. 2 (1991): 353–54. http://dx.doi.org/10.2116/analsci.7.353.

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Bhaskaran, Sundari, M. Yogavel, V. Rajakannan, R. Krishna, D. Velmurugan, and V. Raghukumar. "5-Amino-4-(4-dimethylaminophenyl)-2-(4-methoxyphenyl)-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." Acta Crystallographica Section E Structure Reports Online 59, no. 2 (2003): o200—o202. http://dx.doi.org/10.1107/s1600536803001235.

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Sankaranarayanan, R., D. Velmurugan, S. Shanmuga Sundara Raj, and Hoong-Kun Fun. "5-Amino-4-(4-diethylaminophenyl)-2-(4-hydroxyphenyl)-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." Acta Crystallographica Section C Crystal Structure Communications 57, no. 6 (2001): 726–27. http://dx.doi.org/10.1107/s010827010100422x.

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Sabatini, Stefano, Violetta Cecchetti, Oriana Tabarrini, and Arnaldo Fravolini. "ChemInform Abstract: 8-Methyl-7-Substituted-1,6-naphthyridine-3-carboxylic Acids as New 6-Desfluoroquinolone Antibacterials." ChemInform 31, no. 6 (2010): no. http://dx.doi.org/10.1002/chin.200006144.

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Gómez de Andérez, D., J. R. Helliwell, E. J. Dodson, et al. "Structure of 7-amino-5-bromo-4-methyl-2-oxo-1,2,3,4-tetrahydro-1,6-naphthyridine-8-carbonitrile monohydrate." Acta Crystallographica Section C Crystal Structure Communications 48, no. 1 (1992): 104–6. http://dx.doi.org/10.1107/s0108270191007175.

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Guare, James P., John S. Wai, Robert P. Gomez, et al. "A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors." Bioorganic & Medicinal Chemistry Letters 16, no. 11 (2006): 2900–2904. http://dx.doi.org/10.1016/j.bmcl.2006.03.003.

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Govindasamy, L., D. Velmurugan, V. Raghukumar, Il-Hawn Suh, and V. T. Ramakrishnan. "ChemInform Abstract: 5-Amino-4-(4-diethylaminophenyl)-2-phenyl-7- (pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile." ChemInform 31, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.200022023.

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Al jamal, Jalal A., та Muwaffag Badawneh. "Characterization of the Biochemical Effects of New 1, 8-Naphthyridine Derivatives,β-Receptor Antagonists, in Ventricular Myocytes". Archiv der Pharmazie 336, № 67 (2003): 285–92. http://dx.doi.org/10.1002/ardp.200300781.

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Tucker, Sheryl A., Hardjanti Darmodjo, William E. Acree, et al. "Polycyclic Aromatic Nitrogen Heterocycles. Part IV: Effect of Solvent Polarity, Solvent Acidity, Nitromethane and 1,2,4-Trimethoxybenzene on the Fluorescence Emission Behavior of Select Monoaza- and Diazaarenes." Applied Spectroscopy 46, no. 11 (1992): 1630–35. http://dx.doi.org/10.1366/0003702924926952.

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Abstract:

Fluorescence emission spectra are reported for naphth[2′l′8′7′: 4,10,5]anthra[l,9,8cdef]cinnoline, benzo[lmn][3,8]phenanthroline (also called 2,7-diazapyrene), benz[4,10]anthra[l,9,8cdef]cinnoline, naphtho[8,1,2hij]pyreno[9,10,ldef]phthalazine, acenaphtho[l,2b]pyridine, benzo[a]phenazine, indeno[l,2,3ij][2,7]naphthyridine, and indeno-[l,2,3ij]isoquinoline dissolved in organic nonelectrolyte solvents of varying polarity and acidity. Results of these measurements indicate that naphth[2′,1′,8′,7′:4,10,5]anthra[l,9,8cdef]cinnoline exhibits some signs of probe character as evidenced by changing emi

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Kong, Qinghong, Jianxin Lv, Shengjiao Yan, Kwen-Jen Chang, and Guanlin Wang. "A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells." International Journal of Molecular Sciences 19, no. 10 (2018): 2975. http://dx.doi.org/10.3390/ijms19102975.

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Abstract:

Naphthyridine derivatives are a widely-used class of heterocycles due to their pharmacological activities. A novel compound (10-Methoxy-1,2,3,4-tetrahydrobenzo(g)(1,3) diazepino(1,2-a)-(1,8)naphthyridin-6-yl)(phenyl) methanone (named 3u), showed good anticancer activity in the human malignant melanoma cell line A375 via Thiazolyl Blue Tetrazolium Bromide (MTT) assay. After Western blotting confirmed, we found that 3u induces necroptosis at low concentrations and apoptosis at high concentrations via the upregulation of death receptors and scaffold protein in A375 cells. Furthermore, by combinin

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Mizuki, Y., I. Fujiwara, T. Yamaguchi, and Y. Sekine. "Structure-related inhibitory effect of antimicrobial enoxacin and derivatives on theophylline metabolism by rat liver microsomes." Antimicrobial Agents and Chemotherapy 40, no. 8 (1996): 1875–80. http://dx.doi.org/10.1128/aac.40.8.1875.

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Abstract:

Enoxacin, an antimicrobial fluoroquinolone with a 7-piperazinyl-1, 8-naphthyridine skeleton, is a potent inhibitor of cytochrome P-450-mediated theophylline metabolism. The present study was designed to clarify, using seven enoxacin derivatives, the molecular characteristics of the fluoroquinolone responsible for the inhibition. Three derivatives with methyl-substituted 7-piperazine rings inhibited rat liver microsomal theophylline metabolism to 1,3-dimethyluric acid to an extent similar to that of enoxacin (50% inhibitory concentrations [IC50s] = 0.39 to 0.48 mM). 7-Piperazinyl-quinoline deri

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