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Journal articles on the topic 'Acridine Compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Golcs, Ádám, Panna Vezse, Bálint Árpád Ádám, Péter Huszthy, and Tünde Tóth. "Comparison in practical applications of crown ether sensor molecules containing an acridone or an acridine unit – a study on protonation and complex formation." Journal of Inclusion Phenomena and Macrocyclic Chemistry 101, no. 1-2 (2021): 63–75. http://dx.doi.org/10.1007/s10847-021-01086-2.

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AbstractCrown ethers containing an acridone or an acridine unit are successfully applied opto- and electrochemical cation sensors. The heteroaromatic unit of these macrocycles can be in different forms during the applications, which have a strong influence on the sensing behavior. Moreover, in the case of acridono-macrocycles a prototropic equilibrium takes place upon complexation, which is effected by the physicochemical characteristics. A Pb2+-selective acridono-18-crown-6 ether and its 9-phenylacridino-analogue were used as model compounds for comparing the different forms of the heterocycl

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2

Othman, Salem, and Maria Kozurkova. "Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines." Current Medicinal Chemistry 25, no. 17 (2018): 1968–75. http://dx.doi.org/10.2174/0929867324666170414165019.

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Background: The possible use of acridines as anticancer agents was first considered in the 1920´s. Since then, a large number of acridine drugs have been tested as antitumour agents, including compounds containing sulphur on the acridine chromophore. In this review, we will discuss recent studies which have investigated the anticancer activity of this class of acridine derivatives. Methods: We present the results both of our own decade-long research and also of existing research literature into the anticancer activity of acridine derivatives containing sulphur. The evidence of specific tumor-c

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3

Caffrey, Conor R., Dietmar Steverding, Ryan K. Swenerton, et al. "Bis-Acridines as Lead Antiparasitic Agents: Structure-Activity Analysis of a Discrete Compound Library In Vitro." Antimicrobial Agents and Chemotherapy 51, no. 6 (2007): 2164–72. http://dx.doi.org/10.1128/aac.01418-06.

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ABSTRACT Parasitic diseases are of enormous public health significance in developing countries—a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one helminth parasite species and compared the bioactivities and the cytotoxicities of these compounds toward various mammalian cell lines. Structure-activity relationships demonstrated the influence of both the bis-acridine linker structure and the terminal acridine heterocy

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4

Gabriel, Iwona. "‘Acridines’ as New Horizons in Antifungal Treatment." Molecules 25, no. 7 (2020): 1480. http://dx.doi.org/10.3390/molecules25071480.

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Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical practice, the development of multidrug resistance has become increasingly significant. The urgency to expand the range of therapeutic options for the treatment of f

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5

Khunnawutmanotham, Nisachon, Watthanachai Jumpathong, Chatchakorn Eurtivong, Nitirat Chimnoi, and Supanna Techasakul. "Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents." Journal of Chemical Research 44, no. 7-8 (2020): 410–25. http://dx.doi.org/10.1177/1747519820902674.

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Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2, N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative be

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6

Magesh M and Gandhimathi R. "An overview of pharmacological activities of acridine derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6922–31. http://dx.doi.org/10.26452/ijrps.v11i4.3683.

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The derivatives of acridine can be served as a lead molecule of an antibacterial, anti-viral antiprotozoal, anti-viral, antitubercular, anti-fungal, anti-malarial and anti-cancer agents. Even though the usage of acridine becomes limited due to its side effects, so many potent and safe compounds can be derived through molecular modification in the acridine ring. Since the resistance of pathogens and tumour cells has become more common nowadays, it necessitates the search of new drug candidates. Since the treatment and management of Alzheimer's disease is such a complicated and proper drug regim

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7

Chen, Rui, Lini Huo, Yogini Jaiswal, et al. "Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives." Molecules 24, no. 11 (2019): 2065. http://dx.doi.org/10.3390/molecules24112065.

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Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer and antimicrobial effects. However, literature reveals some side effects associated with use of acridines. It is suggested that hybrid molecules may reduce the side effects and enhance the beneficial properties due to synergistic activity. The objectives of the present study are to synthesize and evaluate the anticancer and antimicrobial properties of new hybrids of acridine thiosemicarbazides derivatives. Results: The structures of the sy

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8

Němcová, Irena, Karel Nesměrák, Božena Kafková, and Jan Sejbal. "Physicochemical Properties of 9-(Alkylsulfanyl)- and 9-(Arylsulfanyl)acridine Derivatives and Their Interaction with (2-Hydroxypropyl)cyclodextrins." Collection of Czechoslovak Chemical Communications 71, no. 2 (2006): 179–89. http://dx.doi.org/10.1135/cccc20060179.

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Acid-base properties and aggregations of 9-(alkylsulfanyl)- and 9-(arylsulfanyl)acridine derivatives were studied as a part of systematic study of physicochemical properties of these compounds synthesized as potential drugs. The effect of the (2-hydroxypropyl)cyclodextrins on these properties and their association with the acridines was also followed.

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9

Lahmy, S., J. M. Salmon, and P. Viallet. "Microspectrofluorometric comparison of benzo(a)pyrene and dibenzo(c,h)acridine metabolism in single living 3T3 fibroblasts." Journal of Histochemistry & Cytochemistry 35, no. 2 (1987): 197–201. http://dx.doi.org/10.1177/35.2.3794313.

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The purpose of this study was to determine if dibenzo(c,h)acridine could be used as a probe for the N-heterocyclic aromatic compound detoxification system. The determination was achieved by cell population studies (histograms) using microspectrofluorimetry on single living cells. The results show a similar metabolic distribution pattern between dibenzo(c,h)acridine and benzo(a)pyrene, whereas important differences appear between 6-aminochrysene and dibenzo(c,h)acridine, respectively amine aromatic and N-heterocyclic aromatic compounds. No differences were observed in the metabolism of benzo(a)

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10

Silva, Daiana K. Frade, Sâmia S. Duarte, Thaís M. H. Lisboa, et al. "Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action." Molecules 25, no. 1 (2019): 29. http://dx.doi.org/10.3390/molecules25010029.

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Tumor cells have specific features, including angiogenesis induction, cell cycle dysregulation, and immune destruction evasion. By inducing a T helper type 2 (Th2) immune response, tumor cells may favor immune tolerance within the tumor, which allows progression of cancer growth. Drugs with potential antitumor activity are the spiro-acridines, which is a promising new class of acridine compounds. Herein, the novel spiro-acridine (E)-5′-oxo-1′-((3,4,5-trimethoxybenzylidene)amino)-1′,5′-dihydro-10H-spiro[acridine-9,2′-pyrrole]-4′-carbonitrile (AMTAC-17) was synthesized and tested for antitumor e

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11

Lisboa, Thaís, Daiana Silva, Sâmia Duarte, et al. "Toxicity and Antitumor Activity of a Thiophene–Acridine Hybrid." Molecules 25, no. 1 (2019): 64. http://dx.doi.org/10.3390/molecules25010064.

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The antitumor effects of thiophene and acridine compounds have been described; however, the clinical usefulness of these compounds is limited due to the risk of high toxicity and drug resistance. The strategy of molecular hybridization presents the opportunity to develop new drugs which may display better target affinity and less serious side effects. Herein, 2-((6-Chloro-2-methoxy-acridin-9-yl)amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]-thiophene-3-carbonitrile (ACS03), a hybrid thiophene–acridine compound with antileishmanial activity, was tested for toxicity and antitumor activity. The toxic

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12

Godard, A., P. Rocca, F. Guillier та ін. "Ortho-directed metallation of π-deficient heterocycles in connection with palladium-catalyzed biaryl cross-coupling Synthesis of marine alkaloids of the pyridoacridine series". Canadian Journal of Chemistry 79, № 11 (2001): 1754–61. http://dx.doi.org/10.1139/v01-147.

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Connection between ortho-directed metallation of π-deficient heterocycles and Suzuki cross-coupling reactions provides a very efficient and fruitful strategy to polycyclic molecules of biological interest. The methodology is used to synthesize alkaloids or precursors and analogues of natural compounds of the pyrido[2,3,4-k,l]acridine series.Key words: marine alkaloids, pyrido[2,3,4-k,l]acridines, metallation, cross-coupling.

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13

Di Giorgio, Carole, Florence Delmas, Nathalie Filloux, et al. "In Vitro Activities of 7-Substituted 9-Chloro and 9-Amino-2-Methoxyacridines and Their Bis- and Tetra-Acridine Complexes against Leishmania infantum." Antimicrobial Agents and Chemotherapy 47, no. 1 (2003): 174–80. http://dx.doi.org/10.1128/aac.47.1.174-180.2003.

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ABSTRACT 9-Chloro and 9-amino-2-methoxyacridines bearing different substituents in position 7, as well as their corresponding unsubstituted dimeric and tetrameric complexes, were investigated for in vitro antiproliferative properties against Leishmania infantum compared to toxicity towards human monocytes. The results clearly confirmed that several compounds of the 2-methoxyacridine series, together with their corresponding dimeric and tetrameric derivatives, had strong in vitro antiparasitic properties. Antileishmanial activity was shown to depend on the nature of both 7- and 9-substituted gr

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14

Tot, Miklos, Dejan Opsenica, Milena Mitric, et al. "New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria." Journal of the Serbian Chemical Society 78, no. 12 (2013): 1847–64. http://dx.doi.org/10.2298/jsc130924112t.

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Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs). The observed inhibition of the BoNT/B LC by ca. 50% is the highest attained inhibitory activity against this serotype by acridine-based compounds to date. With respect to antimalarial activity, adamantane acridines were the most potent derivatives (IC50 = 6-9 nM, SI > 326), indicating that an adamantyl group is a better carries than a steroidal motif f

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15

Tomaščiková, Jana, Ján Imrich, Ivan Danihel, Stanislav Böhm, and Pavol Kristian. "Heterocyclization of (Acridin-9-yl)thiosemicarbazides with Dimethyl Acetylenedicarboxylate." Collection of Czechoslovak Chemical Communications 72, no. 3 (2007): 347–62. http://dx.doi.org/10.1135/cccc20070347.

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Two types of (acridin-9-yl)thiosemicarbazides with the acridine moiety in the thiourea part (Acr-NHCS, 10a, 10b) and hydrazine part (Acr-NHNHCS, 12a-12c) were prepared to investigate their reactions with dimethyl acetylenedicarboxylate. Five-membered thiazolidinone derivatives 15a, 15b, 19a-19c were formed; some aspects of corresponding reaction mechanisms are discussed. 1D and 2D 1H and 13C NMR spectroscopy and DFT quantum chemical calculations were used to elucidate the structure of the compounds.

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16

Chandler, Graham S., and Wolfgang H. F. Sasse. "Bromination of Acridine." Australian Journal of Chemistry 71, no. 4 (2018): 285. http://dx.doi.org/10.1071/ch17619.

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The quantitative determination of the products of bromination of acridine in concentrated sulfuric acid and glacial acetic acid is described. In both cases, the only monobromo products were the 2- and 4-substituted compounds. With sulfuric acid, the 4-isomer predominates whereas in acetic acid, the 2-isomer is predominant. This work expands substantially on the tiny amount of previous work on halogenation of dibenzo-annelated pyridines.

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17

Rong, Liangce, Hui Xu, Lei Li, et al. "An Efficient Fe/H2O Medium in situ Reduction and Cyclization Reaction for the Synthesis of Pyrazolo[3,4-a]acridin-10-one and Pyrazolo[4,3-a]acridin-10-one Derivatives." Synthesis 50, no. 03 (2017): 583–92. http://dx.doi.org/10.1055/s-0036-1589124.

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An efficient and simple method for the synthesis of pyrazolo[3,4-a]acridine and pyrazolo[4,3-a]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H2O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

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18

Karelou, Maria, Vasileios Kourafalos, Athanasia P. Tragomalou, et al. "Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives." Molecules 25, no. 19 (2020): 4584. http://dx.doi.org/10.3390/molecules25194584.

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Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines—namely HCT-116 (colorectal), the uterine sarcoma MES-SA, and its doxorubicin-resistant variant MES-SA/Dx5. A limited number of the new acridines showed marginal cytotoxicity against the tested cell lines; nevertheless, these analogues possessed a similar substitution pattern. The moderate biological activity of these derivatives was attributed to their instability in aqueou

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19

Barek, Jiří, Jaroslav Matějka, and Jiří Zima. "Determination of Acridine, Benz[c]acridine and Dibenz[a,h]acridine by Fast Scan Differential Pulse Voltammetry and Adsorptive Stripping Voltammetry." Collection of Czechoslovak Chemical Communications 59, no. 2 (1994): 294–308. http://dx.doi.org/10.1135/cccc19940294.

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The behaviour of the title compounds in fast scan differential pulse voltammetry and adsorptive stripping voltammetry was studied and the optimum conditions were found for their determination by FS DPV over the concentration region of (2 - 100) .10-7 mol l-1 and by AdSV over the concentration regions of (2 - 10) .10-8 mol l-1 for acridine and dibenz[a,h]acridine and (2 - 100) .10-9 mol l-1 for benz[c]acridine. Practical applicability of the methods to the monitoring of the chemical efficiency of destruction of the carcinogens with potassium permanganate was tested.

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20

IWAMOTO, Yoshihisa, Toshio ITOYAMA, Kyoko YASUDA, et al. "Photodynamic DNA Strand Breaking Activities of Acridine Compounds." Biological & Pharmaceutical Bulletin 16, no. 12 (1993): 1244–47. http://dx.doi.org/10.1248/bpb.16.1244.

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21

Lee, In-Sook Han, Hyun Joo Kil, and Young Ran Ji. "Reactivities of acridine compounds in hydride transfer reactions." Journal of Physical Organic Chemistry 20, no. 7 (2007): 484–90. http://dx.doi.org/10.1002/poc.1182.

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22

Smetanin, Nikolay, Sofia Tokarieva, Svetlana Varenichenko, Oleg Farat, and Victor Markov. "IN SILICO PREDICTION AND MOLECULAR DOCKING STUDIES OF BIOLOGICAL ACTIVITY OF HYDROACRIDINE (QUINOLINE) DERIVATIVES." Ukrainian Chemistry Journal 87, no. 5 (2021): 38–52. http://dx.doi.org/10.33609/2708-129x.87.05.2021.38-52.

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To find biological activity among easily available 2-[(4S,4’S/4R,4’R)-2’,5’-dioxo-2,3,5,6,7,8-hexahydro-1H-spiro[acridine-4,3’-pyrrolidin]-4’-yl]-N-aryl-acetamide, (4S/4R)-4-[(3R/3S)-1-(2-aryl)-2,5-dioxopyrrolidin-3-yl]-1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile, (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1-N-aryl)pyrrolidine-2,5-diones. Methods: Organic synthesis, spectral methods, and molecular docking. We investigated by molecular docking the potential biological activity of previously synthesized compounds containing acridine and pyrrolidine-2,5-diones fragments in their st

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23

Mun, Min Sik, Chan Hee Ryu, Hyunhee So, et al. "Multiple photoluminescence of spiro[acridine-fluorene]-based o-carboranyl compounds with potential as a visual sensory material." Journal of Materials Chemistry C 8, no. 47 (2020): 16896–906. http://dx.doi.org/10.1039/d0tc03801f.

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Two spiro[acridine-9,9′-fluorene]-based closo-o-carboranyl compounds were prepared and they demonstrated the application potential of π-aromatic conjugated o-carboranyl compounds as visual sensory materials.

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24

Cisárikováa, Alžbeta, Pavel Abaffy, Ján Imrich, and Helena Paulíková. "Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines." Acta Chimica Slovaca 8, no. 2 (2015): 97–100. http://dx.doi.org/10.1515/acs-2015-0017.

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Abstract New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently prepared and their action on the cancer cells has been investigated by our research team. In this paper, we studied an effect of UV-A irradiation of two groups of proflavines: 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides (AcrDIMs) and 1’,1”-(acridin-3,6-diyl)-3’,3”-dialkyldithiourea hydrochlorides (AcrDTUs) on a plasmid DNA (pDNA). These compounds induced a photocleavage of pDNA characteristic by generatio

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25

Gunasekaran, K., V. K. Ganesh, D. Velmurugan, et al. "Crystal structures of some acridine diones – laser active compounds." Acta Crystallographica Section A Foundations of Crystallography 52, a1 (1996): C263. http://dx.doi.org/10.1107/s0108767396088976.

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26

Werbovetz, K. A., E. K. Lehnert, T. L. Macdonald, and R. D. Pearson. "Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro." Antimicrobial Agents and Chemotherapy 36, no. 2 (1992): 495–97. http://dx.doi.org/10.1128/aac.36.2.495.

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Filloux, Nathalie, and Jean-Pierre Galy. "New Polyacridine Compounds: Synthesis of Acridine Dimers and Tetramers." Synlett 2001, no. 07 (2001): 1137–39. http://dx.doi.org/10.1055/s-2001-15137.

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28

Wynn, Jessica E., Wenyu Zhang, Denis M. Tebit, et al. "Effect of intercalator and Lewis acid–base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA." MedChemComm 7, no. 7 (2016): 1436–40. http://dx.doi.org/10.1039/c6md00171h.

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29

Csuk, René, Stefan Schwarz, Bianka Siewert, Ralph Kluge, and Dieter Ströhl. "Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids." Zeitschrift für Naturforschung B 67, no. 7 (2012): 731–46. http://dx.doi.org/10.5560/znb.2012-0107.

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Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNA laddering experiments.

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Szymański, Paweł, Paulina Olszewska, Elżbieta Mikiciuk-Olasik, et al. "Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling." Tumor Biology 39, no. 3 (2017): 101042831769501. http://dx.doi.org/10.1177/1010428317695011.

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Lung cancer is still the leading cause of cancer-related death worldwide, indicating a necessity to develop more effective therapy. Acridine derivatives are potential anticancer agents due to their ability to intercalate DNA as well as inhibit enzymes involved in replication and transcription. Recently, we have evaluated anticancer activity of 32 novel acridine-based compounds. We found that the most effective were tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid containing eight and nine carbon atoms in the aliphatic chain. The aim of this study was to determine

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AITKEN, Jacqueline F., Kerry M. LOOMES, Barbara KONARKOWSKA, and Garth J. S. COOPER. "Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid." Biochemical Journal 374, no. 3 (2003): 779–84. http://dx.doi.org/10.1042/bj20030422.

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There is a significant correlation between the occurrence of pancreatic islet amyloid and β-cell failure in advanced type II diabetes mellitus. Islet amyloid is composed primarily of the fibrillar form of the pancreatic hormone, amylin. Using thioflavin-T fluorescence binding and radioprecipitation assays, we investigated whether or not a series of small tricyclic compounds, tetracycline or Congo Red could interfere with the conversion of synthetic human amylin into its insoluble amyloid form. Of the compounds investigated, incubation of human amylin with a 20-fold molar excess of either Congo

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Gobinath, Perumal, Ponnusamy Packialakshmi, Ali Daoud, Saud Alarifi, Akbar Idhayadhulla, and Surendrakumar Radhakrishnan. "Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line." Molecules 25, no. 24 (2020): 5862. http://dx.doi.org/10.3390/molecules25245862.

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In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1H-spiro [acridine-9,2′-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound 1c was more effective (GI50 0.01 µm) against MCF-7 cancer cell lines than standard and other compounds. Therefor

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Halim, Eliza, Hardinsyah Hardinsyah, Noorwati Sutandyo, Ahmad Sulaeman, Made Artika, and Yahdiana Harahap. "KAJIAN BIOAKTIF DAN ZAT GIZI PROPOLIS INDONESIA DAN BRASIL." Jurnal Gizi dan Pangan 7, no. 1 (2013): 1. http://dx.doi.org/10.25182/jgp.2012.7.1.1-7.

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Indonesia has a potency to produce its own propolis, however the propolis market in Indonesia is dominated by imported product, such as from Brazil. Currently, still there is no reasearch which evaluate bioactive compound and nutrient content of Indonesian Propolis (IP) compare with Brazilian Propolis (BP). The objectives of this study were to analyze bioactive compounds and nutrient contents of IP compared to BP. Bioactive compounds and nutrients content were analyzed by gas chromatography–mass spectrophotometry. The results<br />showed both IP and BP contain fenol, α-amyrin, cylolanost

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Burt, Christopher D., and Douglas E. Moore. "PHOTOCHEMICAL SENSITIZATION BY 7-METHYLBENZ[c]ACRIDINE AND RELATED COMPOUNDS." Photochemistry and Photobiology 45, s1 (1987): 729–39. http://dx.doi.org/10.1111/j.1751-1097.1987.tb07874.x.

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35

Iwamoto, Yoshihisa, Ichiji Mifuchi, and L. W. Yielding. "Photodynamic mutagenic action of acridine compounds on yeast Saccharomyces cerevisiae." Mutation Research/Genetic Toxicology 158, no. 3 (1985): 169–75. http://dx.doi.org/10.1016/0165-1218(85)90080-1.

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36

Auparakkitanon, Saranya, Wilai Noonpakdee, Raymond K. Ralph, William A. Denny, and Prapon Wilairat. "Antimalarial 9-Anilinoacridine Compounds Directed at Hematin." Antimicrobial Agents and Chemotherapy 47, no. 12 (2003): 3708–12. http://dx.doi.org/10.1128/aac.47.12.3708-3712.2003.

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ABSTRACT Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-Diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were investigated for their abilities to inhibitβ -hematin formation, to form drug-hematin complexes, and to enhance hematin-induced lysis of red blood cells. Inhibition ofβ -hematin formation was minimal with 3,6-diamino analogs of 9-anilinoacridine and greatest with analogs with a 3,6-diCl su

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37

Brown, CL, MM Harding, GY Krippner, S. Rainone, and LK Webster. "Preparation and Biological Activity of Heteroaryl-Substituted Bile Steroids." Australian Journal of Chemistry 49, no. 1 (1996): 7. http://dx.doi.org/10.1071/ch9960007.

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The synthesis, and growth inhibition studies against the L1210 mouse leukaemia, �MCF-7 human breast cancer and SKOV-3 ovarian carcinoma cell lines, of derivatives of lithocholic acid and cholic acid in which quinoline-3-carboxylate and acridine-9-carboxylate are substituted at the 3 and/or the 24 position are reported. The 3α,24-diheteroaryl-substituted steroid systems, lithocholic acid, cholic acid, quinoline and acridine-9-carboxylic acid showed no significant biological activity against any of the cell lines. In contrast, when either a single quinoline-3-carboxylate or acridine-9-carboxylat

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38

Ferreira, Rubén, Anna Aviñó, Ricardo Pérez-Tomás, Raimundo Gargallo, and Ramon Eritja. "Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers." Journal of Nucleic Acids 2010 (2010): 1–10. http://dx.doi.org/10.4061/2010/489060.

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The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis, which showed a clear affinity for DNA sequences that form G-quadruplexes and parallel triplexes. The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. These spectral changes were used to calculate the binding constants (K). LogKwere found to be in the order of 4–

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39

Mesa-Valle, C. M., J. Castilla-Calvente, M. Sanchez-Moreno, V. Moraleda-Lindez, J. Barbe, and A. Osuna. "Activity and mode of action of acridine compounds against Leishmania donovani." Antimicrobial Agents and Chemotherapy 40, no. 3 (1996): 684–90. http://dx.doi.org/10.1128/aac.40.3.684.

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In the present work, we have assayed both the in vitro and in vivo action of two acridine compounds against Leishmania donovani. As part of this effort, we have studied the possible action mechanism of these compounds at the ultrastructural and biochemical levels and in relation to the synthesis of macromolecules. The two acridinones inhibit the in vitro growth of the promastigote forms of L. donovani at the highest concentration assayed (100 micrograms/ml). The in vivo results indicate that both compounds reduce the number of amastigotes per gram of spleen, and decrease parasitism, by more th

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40

Hussain, Sajid, Farhat Ullah, Abdul Sadiq, et al. "Cytotoxicity of Anchusa arvensis Against HepG-2 Cell Lines: Mechanistic and Computational Approaches." Current Topics in Medicinal Chemistry 19, no. 30 (2020): 2805–13. http://dx.doi.org/10.2174/1568026619666191105103801.

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Background: Liver cancer is a devastating cancer with increasing incidence and mortality rates worldwide. Plants possess numerous therapeutic properties, therefore the search for novel, naturally occurring cytotoxic compounds is urgently needed. Methods: The anticancer activity of plant extracts and isolated compounds from Anchusa arvensis (A. arvensis) were studied against the cell culture of HepG-2 (human hepatocellular carcinoma cell lines) using 3-(4,5-Dimethylthiazol-yl)-diphenyl tetrazoliumbromide (MTT) assay. Apoptosis was investigated by performing Acridine orange –ethidium bromide sta

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Csuk, René, Christian Raschke, Gunnar Göthe, and Stefan Reißmann. "Synthesis of Monomeric Acridine Derived Nucleic Acid Intercalators." Zeitschrift für Naturforschung B 60, no. 1 (2005): 83–88. http://dx.doi.org/10.1515/znb-2005-0113.

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A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. In the presence of ascorbate a reduction of the phage-titer of MS2 phages by several logarithmic decades was achieved.

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42

Singh, Palwinder, Arun Kumar, Sukhmeet Kaur, and Amrinder Singh. "Strategically designed biomodel: engineering C3–C4 cleavage of d-fructose." Organic & Biomolecular Chemistry 13, no. 14 (2015): 4210–20. http://dx.doi.org/10.1039/c4ob02666g.

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Amongst a library of aldolase inspired, rationally designed compounds, the acridine derivative carrying a (S)-Tyr-Gly-(S)-Lys tripeptide selectively effected C3–C4 scissoring of d-fructose and produced d-glyceraldehyde and dihydroxyacetone.

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43

Kishimoto, Mai, Kei Kondo, Munetaka Akita, and Michito Yoshizawa. "A pH-responsive molecular capsule with an acridine shell: catch and release of large hydrophobic compounds." Chemical Communications 53, no. 8 (2017): 1425–28. http://dx.doi.org/10.1039/c6cc09094j.

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Reversible assembly and disassembly of a supramolecular capsule bearing multiple acridine panels occur in water under neutral and acidic conditions, respectively. The pH-responsive capsule encapsulates various hydrophobic compounds in neutral water and subsequently releases them by simple acidification.

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44

Naga Raju, Gollapalli. "GREEN SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTHIC ACTIVITY OF NEWER QUINOLINE DERIVATIVES CONTAINING ACRIDINE MOIETY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 377. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.17226.

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Objectives: Synthesis of newer 3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-9-(2-chloro-6-substituted-quinolin-3-yl)-acridine-1,8(2H,5H,9H,10H)-diones were synthesized by reacting 5,5-dimethylcyclohexane-1,3-dione with substituted 2-chloro-quinoline-3-carbaldehyde in presence of ammonium acetate.Methods: Synthesis was carried out by microwave irradiation method and the synthesized compounds have been characterized using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic pla

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Matzner, Robert A., Roger C. Bales, and Jeanne E. Pemberton. "In situ Raman Spectroscopy of Aza-Arenes Adsorbed at the Aqueous/Silica Interface." Applied Spectroscopy 48, no. 9 (1994): 1043–53. http://dx.doi.org/10.1366/0003702944029406.

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Raman spectroscopy is used to study the effect of pH on the solute/sorbent interactions and the chemical nature of the adsorbed species at the aqueous/silica interface for the aza-arenes acridine, quinoline, and pyridine. The neutral aza-arene is hydrogen-bonded to surface sites in aqueous media in which the pH is above the p Ka of the compound. A protonated aza-arene/ClO4− ion pair interacts with surface sites in aqueous solutions in which the pH is below the pKa of the compound. These results may be useful in predicting the fate of these environmentally significant compounds in groundwater.

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Chemate, Santosh, Yogesh Erande, Dhanraj Mohbiya, and Nagaiyan Sekar. "Acridine derivative as a “turn on” probe for selective detection of picric acid via PET deterrence." RSC Advances 6, no. 87 (2016): 84319–25. http://dx.doi.org/10.1039/c6ra16537k.

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A new acridine based photoinduced electron transfer based fluorescent chemosensor for the detection of nitroaromatic compounds is reported. The probe exhibited high selectivity and sensitivity for the detection of picric acid over trivial explosive in CH<sub>3</sub>OH.

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47

Csuk, René, Thorsten Brezesinski, Gunnar Göthe, Christian Raschke, and Stefan Reißmann. "Synthesis of Dimeric Acridine Derived Nucleic Acid Intercalators." Zeitschrift für Naturforschung B 60, no. 1 (2005): 89–98. http://dx.doi.org/10.1515/znb-2005-0114.

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A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Suitably monoprotected 1,ω-alkyldiamines gave upon reaction with 6,9-dichloro-2-methoxyacridine (1) followed by deprotection and reaction with EDTA dianhydride the target molecules. In the presence of ascorbate a reduction of the phage-titer of the MS2 phages by > 8 logarithmic decades was achieved.

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48

Almeida, Marcel L., Douglas C. F. Viana, Valécia C. M. da Costa, et al. "Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives." Combinatorial Chemistry & High Throughput Screening 23, no. 5 (2020): 359–68. http://dx.doi.org/10.2174/1386207323666200319105239.

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Aim and Objective: In the last decades, cancer has become a major problem in public health all around the globe. Chimeric chemical structures have been established as an important trend on medicinal chemistry in the last years. Thiazacridines are hybrid molecules composed of a thiazolidine and acridine nucleus, both pharmacophores that act on important biological targets for cancer. By the fact it is a serious disease, seven new 3-acridin-9-ylmethyl-thiazolidine-2,4-dione derivatives were synthesized, characterized, analyzed by computer simulation and tested in tumor cells. In order to find ou

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IWAMOTO, YOSHIHISA, HISASHI YOSHIOKA, and YASUTAKE YANAGIHARA. "Singlet oxygen-producing activity and photodynamic biological effects of acridine compounds." CHEMICAL & PHARMACEUTICAL BULLETIN 35, no. 6 (1987): 2478–83. http://dx.doi.org/10.1248/cpb.35.2478.

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50

Zhu, Xiu Hua, Cheng Zhi Zhou, Ran Ran, Zhen Wang, Xin Dong Ma, and Xiao Xiao Li. "Levels and Distributions of Six Toxic PAHs in the Urban Air of Dalian, China During Heating Periods." Advanced Materials Research 518-523 (May 2012): 2572–75. http://dx.doi.org/10.4028/www.scientific.net/amr.518-523.2572.

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Superscript text Superscript textThe concentration of six potential carcinogenic compounds (3-Methylcholanthrene, Dibenz(a,h)acridine, Dibenz(a,i)acridine, Dibenzo(a,e)pyrene, Dibenzo(a,h)pyrene, Dibenzo(a,i)pyrene ) in the urban air of Dalian, China were monitored from November 2009 to March 2010 with active high-volume sampler. They were detected in gaseous phase and particulate phase, respectively. The total concentration of them was 563.2 pg m-3, and they were mainly found in particulate phase with the concentration of 540.5 pg m-3 while the concentration in the gas phase only was 22.7 pg

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