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Journal articles on the topic 'Activité antiplasmodiale'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Kopa, Théodora K., Pierre Tane, Hippolyte K. Wabo, et al. "Activité antiplasmodiale in vitro des composés isolés des écorces du tronc de Vitex thyrsiflora." Comptes Rendus Chimie 19, no. 7 (2016): 807–11. http://dx.doi.org/10.1016/j.crci.2015.10.007.

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Gopalan, Sivaperumal, Kannnan Kulanthai, Gnanavel Sadashivam, Perumal Pachiappan, Sowmiya Rajamani, and Deepak Paramasivam. "Extraction, isolation, characterization, semi-synthesis and antiplasmodial activity of Justicia adathoda leaves." Bangladesh Journal of Pharmacology 11, no. 4 (2016): 878. http://dx.doi.org/10.3329/bjp.v11i4.28569.

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<p>There is a need to investigate the new sources of antimalarial drugs which are more effective against Plasmodium falciparum. The present study was undertaken to evaluate the in vitro antiplasmodial activity of vasicinone, vasicine and 9-oxo-1, 2, 3, 9-tetrahydropyrrolo [2,1-b]quinazolin-3-yl acetate (VA-1). Vasicinone and vasicine were extracted from the leaves of Justicia adhatoda. The novel compound VA-1 was synthesized from alkaloid the alkaloid vasicine, which was isolated from the ethanol extract of J. adhatoda leaves. Vasicine (IC<sub>50</sub> = 89.8 µg/mL) and vasic

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3

Rifaldi, Arif Fadlan, Taslim Ersam, Adi Setyo Purnomo, and Sri Fatmawati. "Antiplasmodial and Antioxidant Activity of Garcinia Bancana Extract." Journal of Hunan University Natural Sciences 50, no. 1 (2023): 278–88. http://dx.doi.org/10.55463/issn.1674-2974.50.1.28.

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Malaria caused by Plasmodium parasites is a significant public health issue, particularly in tropical and subtropical regions. There is also resistance to chloroquine-based therapy, which highlights the need for novel therapeutic agents. Therefore, our project in exploring antiplasmodial agents from Garcinia Indonesia continues. This study evaluates the phytochemical content of G. bancana by the total phenolic content (TPC) and total flavonoid content (TFC) and its in vitro antioxidant and antiplasmodial activities. The TPC and TFC values were determined using a UV-VIS spectrophotometer, while

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4

Zakiah, Mistika, Rul Afiyah Syarif, Mustofa Mustofa, Jumina Jumina, Nela Fatmasari, and Eti Nurwening Sholikhah. "In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives." Journal of Tropical Medicine 2021 (March 31, 2021): 1–11. http://dx.doi.org/10.1155/2021/8866681.

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The previous study showed that xanthone had antiplasmodial activity. Xanthone, with additional hydroxyl groups, was synthesized to increase its antiplasmodial activity. One of the strategies to evaluate a compound that can be developed into an antimalarial drug is by testing its mechanism in inhibiting heme polymerization. In acidic condition, hematin can be polymerized to β-hematin in vitro, which is analog with hemozoin in Plasmodium. This study was conducted to evaluate the antiplasmodial activity of hydroxyxanthone derivative compounds on two strains of Plasmodium falciparum 3D-7 and FCR-3

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5

Okokon, Jude E., Basil Ita, and Aniekan E. Udokpoh. "Antiplasmodial activity ofHomalium letestui." Phytotherapy Research 20, no. 11 (2006): 949–51. http://dx.doi.org/10.1002/ptr.1983.

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6

Okokon, Jude E., Peace M. E. Ubulom, and Aniekan E. Udokpoh. "Antiplasmodial activity ofSetaria megaphylla." Phytotherapy Research 21, no. 4 (2007): 366–68. http://dx.doi.org/10.1002/ptr.2059.

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7

Tshibangu, Pascal Tshisekedi. "Antiplasmodial Activity of Griffipavixanthone and Morelloflavone the Main Compounds from Garcinia Chromocarpa Engl. (Clusiaceae)." International Journal of Pharmacognosy & Chinese Medicine 6, no. 1 (2022): 1–7. http://dx.doi.org/10.23880/ipcm-16000225.

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Ethnopharmacological relevance: The genus Garcinia is a rich source of species mostly used in traditional medicine to treat a many diseases. Bioactive constituents from this genus have been used as antimicrobial, anticancer, antimalarial, anti-inflammatory, hepatoprotective and anti-HIV. According to these properties, major compounds of this plant have been evaluated for their antiplasmodial activity. Materials and methods: The methanol extract of the G. chromocarpa stem bark was used in this study. The chromatographic fractionation of this latest led to the isolation of two major compounds, i

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8

Grace, Mary H., Carmen Lategan, Rocky Graziose, Peter J. Smith, Ilya Raskin, and Mary Ann Lila. "Antiplasmodial Activity of the Ethnobotanical Plant Cassia fistula." Natural Product Communications 7, no. 10 (2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701002.

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In our ongoing investigation of new compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity of fractions and purified compounds from Cassia fistula L., a plant traditionally used by native populations of Tanzania, Zimbabwe, Mozambique and Brazil to treat malaria or symptoms associated with this disease. Crude extracts from leaves, bark and fruits were tested for their antiplasmodial activity against the chloroquine-sensitive strain of Plasmodium falciparum(D10), where leaf extracts showed the highest activity. The chloroform extract of the leaves was f

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9

Hermann, Theresa, Patrick Hochegger, Johanna Dolensky, et al. "Synthesis and Structure-Activity Relationships of New 2-Phenoxybenzamides with Antiplasmodial Activity." Pharmaceuticals 14, no. 11 (2021): 1109. http://dx.doi.org/10.3390/ph14111109.

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The 2-phenoxybenzamide 1 from the Medicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach. Subsequently, twenty-one new derivatives were prepared and tested for their in vitro activity against blood stages of the NF54 strain of P. falciparum. Several insights into structure-activity relationships were revealed. The antiplasmodial activity and cytotoxicity of compounds strongly depended on the substitution pattern of the anilino partial structure as well a

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10

Singh, Kawaljit, Gurminder Kaur, Faith Mjambili, Peter J. Smith, and Kelly Chibale. "Synthesis of metergoline analogues and their evaluation as antiplasmodial agents." Med. Chem. Commun. 5, no. 2 (2014): 165–70. http://dx.doi.org/10.1039/c3md00310h.

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A series of metergoline analogues were synthesized and evaluatedin vitrofor antiplasmodial activity and cytotoxicity towards a mammalian cell line. Some of the compounds exhibited promising selective antiplasmodial activity along with a high selectivity index relative to metergoline.

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11

Onyesom, I., C. O. Elu, J. O. Acha, E. T. Ojugbeli, E. P. Ochonogor, and L. O. Udumebraye. "Evaluation of antiplasmodial activity and inhibitions of lipid peroxidation and parasite haem polymerization activity by medicinal phytochemicals of Phyllanthus amarus." Nigerian Journal of Parasitology 43, no. 2 (2022): 293–302. http://dx.doi.org/10.4314/njpar.v43i2.12.

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Despite the dedicated struggle to eliminate malaria, the current trend of the infection, particularly, in sub-Saharan Africa remains worrisome due to failing control and treatment approaches caused by a myriad of factors. Therefore, the search for new, affordable, and more potent antimalarial drugs, from plants especially, have become the frontline in recent times. This study thus, evaluates the in vitro antiplasmodial, cytotoxic and antioxidant activities of the phytochemical (alkaloids, flavonoids, tannins, saponins, cardiac glycosides and anthraquinones) extracts of Phyllanthus amarus using

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12

Assis, Francisco Flávio Vieira de, José Sousa de Almeida Junior, Tânia Mara Pires Moraes, et al. "Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods." Pharmaceutics 15, no. 4 (2023): 1162. http://dx.doi.org/10.3390/pharmaceutics15041162.

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Malaria is an infectious and parasitic disease caused by protozoa of the genus Plasmodium, which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in Plasmodium populations, leading to the search for potential new active compounds against the parasite. Thus, we aimed to evaluate the in vitro antiplasmodial activity and cytotoxicity of the hydroalcoholic extract of Jucá (Libidibia ferrea) in serial concentrations. Jucá was used in the form of a freeze-dried hydroalcoholic extract. For the cytotoxicity assay, the(3-[4,5-di

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13

Akendengue, B., E. Ngou-Milama, F. Roblot, et al. "Antiplasmodial Activity of Uvaria klaineana." Planta Medica 68, no. 2 (2002): 167–69. http://dx.doi.org/10.1055/s-2002-20245.

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14

Martyn, Derek C., Joseph F. Cortese, Erin Tyndall, et al. "Antiplasmodial activity of piperazine sulfonamides." Bioorganic & Medicinal Chemistry Letters 20, no. 1 (2010): 218–21. http://dx.doi.org/10.1016/j.bmcl.2009.10.130.

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15

Okokon, Jude E., Basil N. Ita, and Aniekan E. Udokpoh. "Antiplasmodial activity of Cylicodiscus gabunensis." Journal of Ethnopharmacology 107, no. 2 (2006): 175–78. http://dx.doi.org/10.1016/j.jep.2006.03.002.

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16

Beldjoudi, Naïma, Lengo Mambu, Mehdi Labaïed, et al. "Flavonoids fromDalbergialouveliiand Their Antiplasmodial Activity." Journal of Natural Products 66, no. 11 (2003): 1447–50. http://dx.doi.org/10.1021/np030008x.

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17

Phuwajaroanpong, Arisara, Prapaporn Chaniad, Walaiporn Plirat, et al. "Antiplasmodial Properties of Aqueous and Ethanolic Extracts of Ten Herbal Traditional Recipes Used in Thailand against Plasmodium falciparum." Tropical Medicine and Infectious Disease 7, no. 12 (2022): 417. http://dx.doi.org/10.3390/tropicalmed7120417.

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This study evaluated the in vitro and in vivo antiplasmodial efficacy and toxicity of aqueous and ethanolic extracts from traditional recipes used in Thailand. The aqueous and ethanolic extracts of ten traditional recipes were tested for in vitro antiplasmodial activity (parasite lactate dehydrogenase assay), cytotoxicity (MTT assay), and hemolysis). Oxidant levels were measured using cell-permeable probe 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate fluorescent dye-based assays. The best candidate was chosen for testing in mouse models using 4-day suppressive and acute tox

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18

Reddy, M. Swapna, and B. Ramya Kuber. "ANTIPLASMODIAL ACTIVITY OF CAESALPINIA CRISTA SEED EXTRACTS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 354–57. http://dx.doi.org/10.22270/jddt.v8i5.1880.

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Objective: To evaluate antiplasmodial activity of Caesalpinia crista seed extracts Methods: Antiplasmodial activity of the seed extracts of Caesalpinia crista against rodent malaria infections in chloroquine sensitive Plasmodium falcipuram strain was investigated, and oral acute toxicity of seed extracts of Caesalpinia crista was also evaluated. Results: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative test

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19

Assis, Francisco Flávio Vieira de, Nazaré Carneiro da Silva, Waldiney Pires Moraes, Lauro Euclides Soares Barata, and Antonio Humberto Hamad Minervino. "Chemical Composition and In Vitro Antiplasmodial Activity of the Ethanolic Extract of Cyperus articulatus var. nodosus Residue." Pathogens 9, no. 11 (2020): 889. http://dx.doi.org/10.3390/pathogens9110889.

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Cyperus articulatus L. is popularly known as priprioca. Its rhizomes are used as a medicine in the treatment of malaria in traditional medicine. Since priprioca oil is extracted for commercial purpose, we evaluated if the components from the priprioca residue can be a source of antiplasmodial active molecules. This study aimed to determine the in vitro antiplasmodial and cytotoxicity activities of the ethanolic extract of C. articulatus as an in vitro antiplasmodial agent. From the solid residue of the plant rhizomes, 40 g samples were removed and subjected to hot extraction using a Soxhlet ex

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20

Munedzimwe, Tatenda C., Robyn L. van Zyl, Donovan C. Heslop, Adrienne L. Edkins, and Denzil R. Beukes. "Semi-Synthesis and Evaluation of Sargahydroquinoic Acid Derivatives as Potential Antimalarial Agents." Medicines 6, no. 2 (2019): 47. http://dx.doi.org/10.3390/medicines6020047.

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Background: Malaria continues to present a major health problem, especially in developing countries. The development of new antimalarial drugs to counter drug resistance and ensure a steady supply of new treatment options is therefore an important area of research. Meroditerpenes have previously been shown to exhibit antiplasmodial activity against a chloroquinone sensitive strain of Plasmodium falciparum (D10). In this study we explored the antiplasmodial activity of several semi-synthetic analogs of sargahydroquinoic acid. Methods: Sargahydroquinoic acid was isolated from the marine brown al

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21

Ngemenya, Moses Njutain, Grace Ntube Abwenzoh, Denis Zofou, Thierry Roland Kang, and James Ajeck Mbah. "Antiplasmodial activity against resistant strains, toxicity and effect on mouse liver enzymes of extracts of Terminalia species found in Southwest Cameroon." Journal of Herbmed Pharmacology 10, no. 1 (2020): 132–38. http://dx.doi.org/10.34172/jhp.2021.14.

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Introduction: Terminalia species have the potential to be exploited in phytomedicine based on their several pharmacological properties including antiplasmodial activity. However, there is need for more data on their antiplasmodial activity and toxicity. This study evaluated the antiplasmodial activities of Terminalia catappa and Terminalia superba found in the coastal area of Cameroon on resistant strains of Plasmodium falciparum not previously tested, and their toxicity. Methods: Three leaf extracts of each plant prepared separately using three organic solvents were screened in vitro on 3 str

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22

Passarini, Guilherme Matos, Daniel Sol Medeiros, Dionatas Ulisses de Oliveira Meneguetti, Renato Abreu Lima, Valdir Alves Facundo, and Patrícia Soares de Maria de Medeiros. "IN VITRO ANTIPLASMODIAL ACTIVITY OF FLOWER EXTRACTS FROM COMBRETUM LEPROSUM MART (MOFUMBO)." Ciência e Natura 39, no. 1 (2016): 84. http://dx.doi.org/10.5902/2179460x21485.

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Malaria is the cause of hundreds of deaths per year , besides putting billions of people at risk of developing disease. When it comes to its therapy, the drugs used currently are losing its efficacy due to increase inn the frequency of resistant strains of the parasite, highlight the importance for the serach of new classes of molecules prsentign antiplasmodial activity. In the present work, the antiplasmodial activities of five extracts from the flowers of Comretum leprosum are described. The method employed for obtaingine the extracts was silica gel column chromatography, and the techniques

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23

Tordzagla, Nestor. "IN VIVO AND IN VITRO ANTIPLASMODIAL ACTIVITY OF EXTRACTS, FRACTIONS AND AN ISOLATED COMPOUND FROM SILK OF ZEA MAYS (CORN SILK)." Journal of medical pharmaceutical and allied sciences 11, no. 3 (2022): 4810–16. http://dx.doi.org/10.55522/jmpas.v11i2.3160.

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This study has investigated antiplasmodial activity of extracts, fractions and an isolated compound from corn silk using both in vivo and in vitro assays. Also, safety studies were carried out on the extract. Pharmacologically, both aqueous and methanolic extracts demonstrated remarkable in vivo antiplasmodial activity of 78.9 ± 1.59 % and 77.3 ± 0.92 % reduction in parasitaemia respectively. The bioassay guided fractionation indicated that ethyl acetate fraction of the methanolic extract of corn silk exhibited highest antiplasmodial activity among the fractions investigated. Employing column

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Mbosso Teinkela, Jean Emmanuel, Thérèse Essonkene, Gisèle Marie Marguerite Etame Loe, Xavier Siwe Noundou, Tsakem Bienvenu, and Cécile Okalla. "Comparative Assessment of the Antiplasmodial Activity and Acute Toxicity of Schumanniophyton magnificum Good & Halle (Rubiaceae) Leaves, Trunk and Roots Methanolic Extracts." Journal of Drug Delivery and Therapeutics 13, no. 3 (2023): 20–26. http://dx.doi.org/10.22270/jddt.v13i3.5959.

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Background: Despite the various medicinal applications of Schumanniophyton magnificum, no comparative data are available to determine the part with best antiplasmodial activity and to guarantee its safety. This work deals with the evaluation of the antiplasmodial activity of methanolic extracts of S. magnificum organs as well as the study of acute toxicity of the most active part. Materials and methods: The methanolic extracts of the leaves, stem bark, trunk wood, root wood and root bark, were obtained by maceration with 96% methanol. Phytochemical screening, based on precipitation and c

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Amrane, Dyhia, Armand Gellis, Sébastien Hutter, et al. "Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines." Molecules 25, no. 17 (2020): 3929. http://dx.doi.org/10.3390/molecules25173929.

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From three previously identified antiplasmodial hit compounds (A–C) and inactive series (D), all based on a 2-trichloromethylquinazoline scaffold, we conducted a structure-activity relationship (SAR) study at position four of the quinazoline ring by synthesizing 42 novel derivatives bearing either a carboxamido- or an alkoxy-group, to identify antiplasmodial compounds and to enrich the knowledge about the 2-trichloromethylquinazoline antiplasmodial pharmacophore. All compounds were evaluated in vitro for their cytotoxicity towards the HepG2 cell line and their activity against the multiresista

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26

Eseyin, Olorunfemi Abraham, Iweh Emmanuel Etim, Emmanuel E. Attih, et al. "In vitro antiplasmodial, cytotoxic and antioxidant effects, and phytochemical constituents of eleven plants used in the traditional treatment of malaria in Akwa Ibom State, Nigeria." Tropical Journal of Pharmaceutical Research 20, no. 1 (2021): 105–11. http://dx.doi.org/10.4314/tjpr.v20i1.16.

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Purpose: To evaluate the antiplasmodial effects of eleven plants (Bombax buonopozense, Carica papaya, Anthocleista djalonensis, Milicia excelsa, Heterotis rotundifolia, Homalim letestui, Starchystarpheta cayennnensis, Ocimum gratissimum, Cleistopholis patens, Chromolaena odorata and Hippocratea africana) reportedly used in the treatment of malaria in Akwa Ibom State of Nigeria. Methods: Phytochemical analysis was done by standard methods, while in vitro antiplasmodial evaluation was carried out using Plasmodium falciparum chloroquine-sensitive and chloroquineresistant strains using lacta

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27

Idris, M. M., and U. Idris. "Assessment of cytotoxicity and antiplasmodial activities of Prosopis africana leaf extracts." Bayero Journal of Pure and Applied Sciences 12, no. 1 (2020): 380–85. http://dx.doi.org/10.4314/bajopas.v12i1.57s.

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Malaria is a major health concern in Sub Saharan Africa and there are few effective treatment options. Nigeria has diverse flora with potent antimalarial phytochemicals and high ethnomedicinal plants uses. This study investigated the phytochemicals, Cytotoxicity and in-vitro antiplasmodial activity of ethnomedicinal plant which is Prosopis africana. Crude ethanol extract and macerated fractions from the ethnomedicinal plant were screened for major classes of antiplasmodial phytochemical compounds i.e., terpenoids, alkaloids, flavonoids, anthraquinones and Steroids. The antiplasmodial assay was

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Budiarti, Mery, and Wahyu Jokopriyambodo. "POTENSI EKSTRAK DAUN PALIASA (Kleinhovia hospita) SEBAGAI ANTI Plasmodium falciparum." Buletin Penelitian Tanaman Rempah dan Obat 31, no. 2 (2020): 85. http://dx.doi.org/10.21082/bullittro.v31n2.2020.85-96.

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<em>Paliasa (</em>Kleinhovia hospita<em>) is known as a plant that has been used empirically for malaria treatment, especially in Eastern Indonesia. However, scientific publications regarding to the antiplasmodial activity of these natural resources are still limited. The aim of this study was to examine the potency of paliasa leaves as antiplasmodial against </em>Plasmodium falciparum<em> parasite. The procedure included sample and extract preparation, antiplasmodial in vitro activity testing on </em>P. falciparum<em> strain 3D7, and phytochemical scr

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Lima, Marilia NN, Bruno J. Neves, Gustavo C. Cassiano, et al. "Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria." Future Medicinal Chemistry 11, no. 20 (2019): 2635–46. http://dx.doi.org/10.4155/fmc-2018-0255.

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Aim: Computer-aided drug design approaches were applied to identify chalcones with antiplasmodial activity. Methodology: The virtual screening was performed as follows: structural standardization of in-house database of chalcones; identification of potential Plasmodium falciparum protein targets for the chalcones; homology modeling of the predicted P. falciparum targets; molecular docking studies; and in vitro experimental validation. Results: Using these models, we prioritized 16 chalcones with potential antiplasmodial activity, for further experimental evaluation. Among them, LabMol-86 and L

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TIKO, Gerard Hodevé, Adandé MEDJIGBODO, Rafiou ADAMOU, Abdou Madjid Olatoundé AMOUSSA, Luc Salako DJOGBENOU, and Latifou LAGNIKA. "Scientific Baseline Information for the Potential Use of Hibiscus surattensis L against Malaria: Phytochemistry and Biological Studies." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 127–35. http://dx.doi.org/10.22270/jddt.v10i5-s.4491.

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Background and aim: Hibiscus surattensis L. is a medicinal plant widely used traditionally in Benin to treat malaria. This study was designed to investigate antiplasmodial activity, hemolytic power, acute toxicity, antioxidant activity and phytochemical content of H. surattensis. Methodology: Bioassay-guided isolation approach was adopted and extracts and fractions collected were continuously tested in vitro against Chloroquine-sensitive and field isolate strains of Plasmodium falciparum by immune-dosage of Plasmodium lactate dehydrogenase. Hemolytic effect and acute toxicity of extracts

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Osman, Che Puteh, Nor Hadiani Ismail, Aty Widyawaruyanti, et al. "Evaluation of a Series of 9,10-Anthraquinones as Antiplasmodial Agents." Letters in Drug Design & Discovery 16, no. 3 (2019): 353–63. http://dx.doi.org/10.2174/1570180815666180607085102.

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Background: A phytochemical study on medicinal plants used for the treatment of fever and malaria in Africa yielded metabolites with potential antiplasmodial activity, many of which are Anthraquinones (AQ). AQs have similar sub-structure as naphthoquinones and xanthones, which were previously reported as novel antiplasmodial agents. </P><P> Objective: The present study aimed to investigate the structural requirements of 9,10- anthraquinones with hydroxy, methoxy and methyl substituents to exert strong antiplasmodial activity and to investigate their possible mode of action. </P&

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Tlhapi, Dorcas, Isaiah Ramaite, Teunis Van Ree, Chinedu Anokwuru, Taglialatela-Scafati Orazio, and Heinrich Hoppe. "Isolation, Chemical Profile and Antimalarial Activities of Bioactive Compounds from Rauvolfia caffra Sond." Molecules 24, no. 1 (2018): 39. http://dx.doi.org/10.3390/molecules24010039.

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In this study, the chemical profile of a crude methanol extract of Rauvolfia caffra Sond was determined by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Column chromatography and preparative thin layer chromatography were used to isolate three indole alkaloids (raucaffricine, N-methylsarpagine and spegatrine) and one triterpenoid (lupeol). The antiplasmodial activity was determined using the parasite lactate dehydrogenase (pLDH) assay. The UPLC-MS profile of the crude extract reveals that the major constituents of R. caffra are raucaffricine (m/z 513.2) and spegatrine (m

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Melariri, Paula, William Campbell, Paschal Etusim, and Peter Smith. "Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts fromCarica papayaLeaves." Journal of Parasitology Research 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/104954.

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We investigated the antiplasmodial properties of crude extracts fromCarica papayaleaves to trace the activity through bioassay-guided fractionation. The greatest antiplasmodial activity was observed in the ethyl acetate crude extract.C. papayashowed a high selectivity forP. falciparumagainst CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chloroquine-resistant DD2 strains, respectively.Carica papayaethyl acetate extract was subjected to bioassay-guided fractionation to ascertain the most active fraction, which was purified and identified using high-

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Tajuddeen, Nasir, Tarryn Swart, Heinrich C. Hoppe, and Fanie R. van Heerden. "Antiplasmodial Activity of Vachellia xanthophloea (Benth.) P.J.H. Hurter (African Fever Tree) and Its Constituents." Pharmaceuticals 15, no. 4 (2022): 470. http://dx.doi.org/10.3390/ph15040470.

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Vachellia xanthophloea is used in Zulu traditional medicine as an antimalarial remedy. A moderate antiplasmodial activity was previously reported for extracts of the plant against D10 Plasmodium falciparum. This study aimed to identify the phytochemicals responsible for the antiplasmodial activity of the leaf extract. The compounds were isolated by chromatography and their structures were determined using spectroscopic and spectrometric methods. The antiplasmodial activity was evaluated using a parasite lactate dehydrogenase assay and cytotoxicity was determined using a resazurin assay. The et

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Macuamule, Cristiano J., Erick T. Tjhin, Collins E. Jana, et al. "A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3666–68. http://dx.doi.org/10.1128/aac.04970-14.

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ABSTRACTPantothenamides inhibit blood-stagePlasmodium falciparumwith potencies (50% inhibitory concentration [IC50], ∼20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor coenzyme A. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification of the pantothenamide structure led to the identification of α-methyl-N-phenethyl-pantothenamide, a pantothenamide resistant to degradation, with excellent antiplasmodial activity (IC50, 52 ± 6 nM), target specificity, and

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Lande, Duc Hoàng, Abed Nasereddin, Arne Alder, et al. "Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones." Molecules 26, no. 16 (2021): 4739. http://dx.doi.org/10.3390/molecules26164739.

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Malaria is one of the most dangerous infectious diseases. Because the causative Plasmodium parasites have developed resistances against virtually all established antimalarial drugs, novel antiplasmodial agents are required. In order to target plasmodial kinases, novel N-unsubstituted bisindolylcyclobutenediones were designed as analogs to the kinase inhibitory bisindolylmaleimides. Molecular docking experiments produced favorable poses of the unsubstituted bisindolylcyclobutenedione in the ATP binding pocket of various plasmodial protein kinases. The synthesis of the title compounds was accomp

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Kumar, Sanjay, Sajal Kumar Das, Sumanta Dey, et al. "Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]Pyridine." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 705–15. http://dx.doi.org/10.1128/aac.00898-07.

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ABSTRACT A series of [(aryl)arylsufanylmethyl]pyridines (AASMP) have been synthesized. These compounds inhibited hemozoin formation, formed complexes (KD = 12 to 20 μM) with free heme (ferriprotoporphyrin IX) at a pH close to the pH of the parasite food vacuole, and exhibited antimalarial activity in vitro. The inhibition of hemozoin formation may develop oxidative stress in Plasmodium falciparum due to the accumulation of free heme. Interestingly, AASMP developed oxidative stress in the parasite, as evident from the decreased level of glutathione and increased formation of lipid peroxide, H2O

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Radzishevsky, I., M. Krugliak, H. Ginsburg, and A. Mor. "Antiplasmodial Activity of Lauryl-Lysine Oligomers." Antimicrobial Agents and Chemotherapy 51, no. 5 (2007): 1753–59. http://dx.doi.org/10.1128/aac.01288-06.

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ABSTRACT The ever evolving resistance of the most virulent malaria parasite, Plasmodium falciparum, to antimalarials necessitates the continuous development of new drugs. Our previous analysis of the antimalarial activities of the hemolytic antimicrobial peptides dermaseptins and their acylated derivatives implicated the importance of hydrophobicity and charge for drug action. Following these findings, an oligoacyllysine (OAK) tetramer designed to mimic the characteristics of dermaseptin was synthesized and assessed for its antimalarial activity in cultures of P. falciparum. The tetramer inhib

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Desgrouas, Camille, Charles Chapus, Jérôme Desplans, et al. "In vitro antiplasmodial activity of cepharanthine." Malaria Journal 13, no. 1 (2014): 327. http://dx.doi.org/10.1186/1475-2875-13-327.

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Mitaine-Offer, A. C., M. Sauvain, A. Valentin, J. Callapa, M. Mallié, and M. Zèches-Hanrot. "Antiplasmodial activity of Aspidosperma indole alkaloids." Phytomedicine 9, no. 2 (2002): 142–45. http://dx.doi.org/10.1078/0944-7113-00094.

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Kuria, Kimani A. M., Hezekiah Chepkwony, Cindy Govaerts, et al. "The Antiplasmodial Activity of Isolates fromAjugaremota." Journal of Natural Products 65, no. 5 (2002): 789–93. http://dx.doi.org/10.1021/np0104626.

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Frédérich, Michel, Marie-José Jacquier, Philippe Thépenier, et al. "Antiplasmodial Activity of Alkaloids from VariousStrychnosSpecies." Journal of Natural Products 65, no. 10 (2002): 1381–86. http://dx.doi.org/10.1021/np020070e.

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Bajsa, Joanna, Adam McCluskey, Christopher P. Gordon, et al. "The antiplasmodial activity of norcantharidin analogs." Bioorganic & Medicinal Chemistry Letters 20, no. 22 (2010): 6688–95. http://dx.doi.org/10.1016/j.bmcl.2010.09.004.

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Zhang, Wen-Qiang, Yun He, Qun Yu, et al. "Polyvalent effect enhances diglycosidic antiplasmodial activity." European Journal of Medicinal Chemistry 121 (October 2016): 640–48. http://dx.doi.org/10.1016/j.ejmech.2016.05.069.

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Khankischpur, Mehdi, Rolf D. Walter, and Thomas Kurz. "Synthesis and Antiplasmodial Activity of 4-Alkylidene(arylidene)hydrazono-1,3-oxazinan-2-ones and 3-Hydroxy-N'-alkylidene(arylidene)propanehydrazonamides." Australian Journal of Chemistry 63, no. 10 (2010): 1430. http://dx.doi.org/10.1071/ch10052.

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Previously unreported 6-substituted 4-alkylidene(arylidene)hydrazono-1,3-oxazinan-2-ones and a series of open-chained 3-hydroxy-N′-alkylidene(arylidene)propanehydrazonamides were synthesized and evaluated for their in vitro antiplasmodial activity. The most active 3-hydroxy-N′-alkylidene(arylidene)propanehydrazonamide exhibits potent in vitro antiplasmodial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum and demonstrates an IC50 value of 0.2 µM.

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Abbas, Jamilah, and Syafruddin Syafruddin. "Antiplasmodial Evaluation of One Compound from Calophyllum flavoranulum." Indonesian Journal of Chemistry 14, no. 2 (2014): 185–91. http://dx.doi.org/10.22146/ijc.21257.

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Calophyllum flavoranulum (Clusiaceae family) is a big tree and medical plants from the tropical rain forest of the Indonesian continent. The organic extracts from stem bark yielded phenyl coumarin. The structure was elucidated with the aid of spectroscopic technique. Antiplasmodial activities of isolated compound was tested in vivo against Plasmodium berghei parasite and showed the best antiplasmodial activity. New flavoranulum coumarin compound showed activity against P. berghei parasite with inhibition growth 0, 31.33, 40, 30.67, 46 and 34% at dosage 1.1x10-10, 1.1x10-9, 1.1x10-8, 1.1x10-7,

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Wahyuni, Dwi Kusuma, Shilfiana Rahayu, Andi Hamim Zaidan, Wiwied Ekasari, Sehanat Prasongsuk, and Hery Purnobasuki. "Growth, secondary metabolite production, and in vitro antiplasmodial activity of Sonchus arvensis L. callus under dolomite [CaMg(CO3)2] treatment." PLOS ONE 16, no. 8 (2021): e0254804. http://dx.doi.org/10.1371/journal.pone.0254804.

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Malaria is still a global health problem. Plasmodium is a single-cell protozoan parasite that causes malaria and is transmitted to humans through the female Anopheles mosquito. The previous study showed that Sonchus arvensis L. callus has antiplasmodial activity. Several treatments are needed for callus quality improvement for antimalarial compound production. This study aimed to examine the effect of dolomite [CaMg(CO3)2] on growth (morpho-anatomical structure and biomass), secondary metabolite production, and in vitro antiplasmodial activity of S. arvensis L. callus. In this study, leaf expl

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Reddy M., Swapna, and Ramya Kuber B. "ISOLATION, CHARACTERIZATION AND EVALUATION FOR ANTIPLASMODIAL ACTIVITY OF EXTRACTED CONSTITUENTS FROM CAESALPINIA CRISTA LINN SEEDS." Indian Drugs 60, no. 02 (2023): 44–49. http://dx.doi.org/10.53879/id.60.02.11933.

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The present work deals with extraction, isolation and characterization of phytoconstituents from seeds of Caesalpinia crista Linn and the study of their antiplasmodial activity. The phytoconstituents were extracted using soxhlet apparatus and separated by column chromatography. Structural elucidation was done by FTIR spectroscopy, NMR spectroscopy and mass spectrometry. Terpenoid, saponin and steroidal glucocorticoid were successfully isolated and identified. These constituents were tested for antimalarial activity using Peter’s 4 day suppressive test. Antiplasmodial efficacy was evaluated by

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Grellier, Philippe, Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, and Narimantas Čėnas. "Role of Single-Electron Oxidation Potential and Lipophilicity in the Antiplasmodial in vitro Activity of Polyphenols: Comparison to Mammalian Cells." Zeitschrift für Naturforschung C 63, no. 5-6 (2008): 445–50. http://dx.doi.org/10.1515/znc-2008-5-622.

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In spite of extensive studies, the structure-activity relationships in the action of polyphenols against the malaria parasite Plasmodium falciparum are poorly understood so far. As the mammalian cell cytotoxicity of polyphenols shows a negative dependence on the potential of the phenoxyl radical/phenol redox couple (E27 ), due to the involvement of prooxidant events, and a positive dependence on the octanol/water distribution coefficient at pH 7.0 (log D), we examined the role of these parameters in their antiplasmodial in vitro activity. We found that the concentrations of hydroxybenzenes cau

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Kpadonou-Kpoviessi, Bénédicta, Basile Goueti, Hyacinthe Agnimonhan, et al. "Investigation of the anti-salmonellal and antiplasmodial properties of leaf extracts of Rourea coccinea Beninese medicinal plant." International Journal of Biological and Chemical Sciences 17, no. 6 (2024): 2405–11. http://dx.doi.org/10.4314/ijbcs.v17i6.21.

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Rourea coccinea, also called Byrsocarpus coccineus is a medicinal plant widely used in primary health care in West Africa and in this case in Benin. In the present study, the hydroethanolic extract of these leaves was investigated for its anti-salmonella and antiplasmodial properties. The evaluation of anti-salmonella activity was carried out by the micro dilution method associated with resazurine while that of antiplasmodial activity by method described by Syber Green. Minimum inhibitory concentrations (MICs) of the hydroethanolic extract against Salmonella strains were higher than 2000 μg/mL

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