Log in

Relevant bibliographies by topics / Adenine/pharmacology / Journal articles

To see the other types of publications on this topic, follow the link: Adenine/pharmacology.

Journal articles on the topic 'Adenine/pharmacology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Adenine/pharmacology.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

She, Jing, Rui Sheng, and Zheng-Hong Qin. "Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors." Aging and disease 12, no. 8 (2021): 1879. http://dx.doi.org/10.14336/ad.2021.0523.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Popova, Olga, Daria Bylinskaya, Anastasia Nikitina та Olga Ukrainskaya. "The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase". BIO Web of Conferences 181 (2025): 01026. https://doi.org/10.1051/bioconf/202518101026.

Full text

Abstract:

The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle. The relevance of studying cytochrome P450 enzymes and their activator is determined by the development of methods for effective diagnostics of hepatobiliary pathologies. It was found that the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase functions as a redox “partner” for cytochromes P450. An electrochemical method used to study

APA, Harvard, Vancouver, ISO, and other styles

3

Zeng, Yijia, Tingna Li, Xiaorui Zhang, et al. "Effects of Haima Duobian Pill in a Rat Model of Kidney Yang Deficiency Syndrome." Evidence-Based Complementary and Alternative Medicine 2021 (January 5, 2021): 1–13. http://dx.doi.org/10.1155/2021/6696234.

Full text

Abstract:

Objective. Modern research shows that Haima Duobian pill (HDP) can relieve the kidney yang deficiency syndrome (KYDS), but the mechanism is still unclear. The aim of this work was to study the effects of HDP in a rat model of KYDS. Materials and Methods. The network pharmacology methods were used to predict the therapeutic effects of Haima Duobian pill. Adenine was used to establish the rat model of kidney yang deficiency syndrome. The general physical signs of rats were observed after different doses of Haima Duobian pill (HDP) were given. Serum cyclic adenosine monophosphate (cAMP), cyclic g

APA, Harvard, Vancouver, ISO, and other styles

4

Gromova, O. A., and I. Yu Torshin. "Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis." Experimental and Clinical Gastroenterology, no. 10 (January 18, 2023): 111–25. http://dx.doi.org/10.31146/1682-8658-ecg-206-10-111-125.

Full text

Abstract:

Nicotinamide (niacin) is a PP (Pellagra-Preventive) vitamer necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). The NAD molecule is a coenzyme of proteins involved in the synthesis of ATP from fats and carbohydrates. For more than 50 years, nicotinamide has been used as an antihyperlipidemic agent and to improve blood microcirculation. The results of a systematic analysis of 70417 publications on the pharmacology of nicotinamide made it possible to clarify the molecular mechanisms of the vasoprotective action of nicotinamide (including anti-inflammatory action), to summariz

APA, Harvard, Vancouver, ISO, and other styles

5

Al-Salabi, Mohammed I., and Harry P. de Koning. "Purine Nucleobase Transport in Amastigotes of Leishmania mexicana: Involvement in Allopurinol Uptake." Antimicrobial Agents and Chemotherapy 49, no. 9 (2005): 3682–89. http://dx.doi.org/10.1128/aac.49.9.3682-3689.2005.

Full text

Abstract:

ABSTRACT Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important human pathogens, because they mediate the uptake of purine analogues, as well as some nonpurine drugs, that can be selectively cytotoxic to the parasites. We here report the first identification and characterization of a purine nucleobase transporter in Leishmania amastigote

APA, Harvard, Vancouver, ISO, and other styles

6

Ray, Adrian S., Jennifer E. Vela, Constantine G. Boojamra, et al. "Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 648–54. http://dx.doi.org/10.1128/aac.01209-07.

Full text

Abstract:

ABSTRACT GS-9131 is a phosphonoamidate prodrug of the novel ribose-modified phosphonate nucleotide analog GS-9148 that demonstrates potent anti-human immunodeficiency virus type 1 (HIV-1) activity and an excellent resistance profile in vitro. Prodrug moieties were optimized for the efficient delivery of GS-9148 and its active diphosphate (DP) metabolite to lymphoid cells following oral administration. To understand the intracellular pharmacology of GS-9131, incubations were performed with various types of lymphoid cells in vitro. The intracellular accumulation and antiviral activity levels of

APA, Harvard, Vancouver, ISO, and other styles

7

Fu, Yu, Xinya Zhang, Zhenguang Song, Lili Wang, Peng Zhao, and Suiqing Chen. "Exploring the Active Constitutions of Peach Blossom for Amelioration of Loperamide-Induced Mice Constipation by Ultra-Performance Liquid Chromatography-Mass Spectrometry Combined with Network Pharmacology." Natural Product Communications 18, no. 3 (2023): 1934578X2311611. http://dx.doi.org/10.1177/1934578x231161184.

Full text

Abstract:

Constipation is a multifactorial health problem resulting from systemic or neurologic disorders including medication. Peach blossom, an edible flower, could promote defecation, urination, and improve abdominal pain. However, the active components and mechanisms of action remain unclear. In the present study, we established a loperamide-induced mice constipation model to validate the anti-constipation activity of peach blossom. Some classical biomarkers for constipation, including fecal water content, gastrointestinal transit ratio, and fecal pellet weight were used to evaluate the efficacy of

APA, Harvard, Vancouver, ISO, and other styles

8

Grim, Shellee A., and Frank Romanelli. "Tenofovir Disoproxil Fumarate." Annals of Pharmacotherapy 37, no. 6 (2003): 849–59. http://dx.doi.org/10.1345/aph.1c388.

Full text

Abstract:

OBJECTIVE: To review the pharmacology, virology, pharmacokinetics, efficacy, safety, resistance profile, and clinical use of tenofovir disoproxil fumarate. DATA SOURCES: A MEDLINE search was performed (1966–August 2002) using the following terms: tenofovir, tenofovir disoproxil fumarate, PMPA (9-( R)-[2-(phosphonomethoxy)propyl]adenine), and Viread. Abstracts from HIV-related meetings were reviewed. DATA EXTRACTION AND STUDY SELECTION: Publications and meeting abstracts regarding tenofovir were reviewed. The most recent and pertinent items were included. DATA SYNTHESIS: Tenofovir disoproxil fu

APA, Harvard, Vancouver, ISO, and other styles

9

Gaffer, Hatem, Mounir Salem, and Magda Marzouk. "Synthesis of 4-hydroxy coumarin dyes and their applications." Pigment & Resin Technology 45, no. 5 (2016): 320–29. http://dx.doi.org/10.1108/prt-09-2014-0071.

Full text

Abstract:

Purpose The present study aims to focus on the possibility of developing new eco-friendly azo dyes with good colouristic application properties, exhibiting biological and pharmacological activities. Design/methodology/approach Coupling of 4-hydroxycoumarin with a variety of aromatic diazonium salts of 2-aminothiazole, 2-aminobenzothiazole, 4-aminoantipyrine, 4-aminoacetophenone, adenine sulphate, a-naphthylamine and sulphadimidine to produce novel azo dyes. The compounds were fully characterised using spectroscopic and analytical methods. All of the compounds were tested for their antimicrobia

APA, Harvard, Vancouver, ISO, and other styles

10

Chu, Jiaxin, Jianqiang Song, Zhuolin Fan, et al. "Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation." Pharmaceuticals 18, no. 5 (2025): 605. https://doi.org/10.3390/ph18050605.

Full text

Abstract:

Background/Objectives: Diabetic encephalopathy (DE), a severe neurological complication of diabetes mellitus (DM), is characterized by cognitive dysfunction. 3-Methyladenine (3-MA), a methylated adenine derivative, acts as a biomarker for DNA methylation and exhibits hypoglycemic and neuroprotective properties. However, the pharmacological mechanisms underlying 3-MA’s therapeutic effects on diabetic microvascular complications remain incompletely understood, owing to the intricate and multifactorial pathogenesis of DE. Methods: This study employed network pharmacology and molecular docking tec

APA, Harvard, Vancouver, ISO, and other styles

11

Radenkovic, Dina, Reason, and Eric Verdin. "Clinical Evidence for Targeting NAD Therapeutically." Pharmaceuticals 13, no. 9 (2020): 247. http://dx.doi.org/10.3390/ph13090247.

Full text

Abstract:

Nicotinamide adenine dinucleotide (NAD) pharmacology is a promising class of treatments for age-related conditions that are likely to have a favorable side effect profile for human use, given the widespread use of the NAD precursor vitamin B3 supplements. However, despite several decades of active investigation and numerous possible biochemical mechanisms of action suggested, only a small number of randomized and adequately powered clinical trials of NAD upregulation as a therapeutic strategy have taken place. We conducted a systematic review of the literature, following the PRISMA guidelines,

APA, Harvard, Vancouver, ISO, and other styles

12

Zhou, Lin, Xiaohui Wang, Zhi Sun, et al. "Study on the mechanism of Shenkang injection in the treatment of chronic renal failure based on the strategy of "Network pharmacology—Molecular docking—Key target validation"." PLOS ONE 18, no. 10 (2023): e0291621. http://dx.doi.org/10.1371/journal.pone.0291621.

Full text

Abstract:

Objective To explore the potential mechanism of Shenkang injection (SKI) in the treatment of chronic renal failure based on network pharmacology and molecular docking technology, and to verify the core targets and key pathways by using the renal failure model. Methods The active components and targets of Shenkang injection were retrieved by TCMSP database, and the disease related targets were obtained by OMIM, GeneCards and other databases. Then, the intersection was obtained, and were imported into String database for PPI analysis. After further screening of core targets, GO and KEGG analysis

APA, Harvard, Vancouver, ISO, and other styles

13

Zhang, Zhi-miao, Lei Yang, Yue Wan, et al. "The synergic renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced chronic kidney disease rats based on integrated plasma metabolomics and network pharmacology approach." Life Sciences 278 (August 2021): 119545. http://dx.doi.org/10.1016/j.lfs.2021.119545.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Zhao, Hong, Qi Gao, Ling-zhou Kong, et al. "Study on Network Pharmacological Analysis and Preliminary Validation to Understand the Mechanisms of Plantaginis Semen in Treatment of Gouty Nephropathy." Evidence-Based Complementary and Alternative Medicine 2020 (November 27, 2020): 1–12. http://dx.doi.org/10.1155/2020/8861110.

Full text

Abstract:

Plantaginis Semen (PS) has been used to promote diuresis and clear away dampness. Recent reports have shown that PS can be used to treat gouty nephropathy (GN). However, the action and mechanism of PS have not been well defined in treating GN. The present study aimed to define the molecular mechanisms of PS as a potential therapeutic approach to treat GN. A combination of network pharmacology and validation experiments in GN is used to understand the potential mechanism. Information on pharmaceutically active compounds in PS and gene information related to GN was obtained from public databases

APA, Harvard, Vancouver, ISO, and other styles

15

Sun, Kaiyue, Yingzi Zhang, Yingliang Li, Pengyu Yang, and Yingting Sun. "Biochemical Targets and Molecular Mechanism of Matrine against Aging." International Journal of Molecular Sciences 24, no. 12 (2023): 10098. http://dx.doi.org/10.3390/ijms241210098.

Full text

Abstract:

The aim of this study is to explore the potential targets and molecular mechanism of matrine (MAT) against aging. Bioinformatic-based network pharmacology was used to investigate the aging-related targets and MAT-treated targets. A total of 193 potential genes of MAT against aging were obtained and then the top 10 key genes (cyclin D1, cyclin-dependent kinase 1, Cyclin A2, androgen receptor, Poly [ADP-ribose] polymerase-1 (PARP1), histone-lysine N-methyltransferase, albumin, mammalian target of rapamycin, histone deacetylase 2, and matrix metalloproteinase 9) were filtered by the molecular com

APA, Harvard, Vancouver, ISO, and other styles

16

Li, Dong, Yuzhe Liu, Quancao Zhan, et al. "Astragaloside IV Blunts Epithelial–Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy." Cells 12, no. 13 (2023): 1777. http://dx.doi.org/10.3390/cells12131777.

Full text

Abstract:

Previous studies show that astragaloside IV (ASIV) has anti-renal fibrosis effects. However, its mechanism remains elusive. In this study, we investigated the anti-fibrosis mechanisms of ASIV on chronic kidney disease (CKD) in vivo and in vitro. A CKD model was induced in rats with adenine (200 mg/kg/d, i.g.), and an in vitro renal fibrosis model was induced in human kidney-2 (HK-2) cells treated with TGF-β1. We revealed that ASIV significantly alleviated renal fibrosis by suppressing the expressions of epithelial–mesenchymal transition (EMT)-related proteins, including fibronectin, vimentin,

APA, Harvard, Vancouver, ISO, and other styles

17

Praveena, M. Maria. "The Science of Aging: Therapeutic Approaches to Extend Lifespan and Healthspan." SBV Journal of Basic, Clinical and Applied Health Science 8, no. 1 (2025): 13–17. https://doi.org/10.4103/sbvj.sbvj_11_25.

Full text

Abstract:

The growing field of antiaging pharmacology represents a significant shift in our understanding of aging, characterized by progressive physiological decline and increased susceptibility to diseases. The World Health Organization estimates that by 2050, the number of individuals aged 60 years and older will reach 2 billion, emphasizing the need for interventions that not only extend lifespan but also enhance healthspan – the duration of life spent free from chronic disease. Key mechanisms of aging include cellular senescence, inflammation, mitochondrial dysfunction, and telomere shortening, whi

APA, Harvard, Vancouver, ISO, and other styles

18

Li, Na, Mukaram Amatjan, Pengke He, et al. "Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal Cichorium intybus formula in attenuating adenine and ethambutol hydrochloride-induced hyperuricemic nephropathy in rats." Pharmaceutical Biology 60, no. 1 (2022): 2338–54. http://dx.doi.org/10.1080/13880209.2022.2147551.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Lüscher, Alexandra, Estelle Lamprea-Burgunder, Fabrice E. Graf, Harry P. de Koning, and Pascal Mäser. "Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity." International Journal for Parasitology: Drugs and Drug Resistance 4, no. 1 (2014): 55–63. http://dx.doi.org/10.1016/j.ijpddr.2013.12.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Gori, Pooja, Alkesh Patel, Nilay Solanki, Umang Shah, Veena Patel, and Sandip Patel. "Protective effects of lycopene against adenine-induced chronic renal failure in rats." Indian Journal of Physiology and Pharmacology 65 (August 10, 2021): 74–85. http://dx.doi.org/10.25259/ijpp_188_2020.

Full text

Abstract:

Objectives: Chronic renal failure (CRF) is a public health concern in both developed and developing countries. Therefore, there is still a need to look for secure and successful agents that can either minimise or prevent CRF from advancing to end-stage renal disorder. This study aimed to assess the effect of lycopene on adenine-induced CRF in the rat. Materials and Methods: Animals were divided into five groups (n = 6). Normal control group received normal vehicle, disease control group received orally adenine (50 mg/kg/day), L 100 group received orally lycopene (100 mg/kg/day) + adenine (50 m

APA, Harvard, Vancouver, ISO, and other styles

21

Miller, Richard L., Carol L. K. Sabourin, and Thomas A. Krenitsky. "Trypanosoma cruzi adenine nucleoside phosphorylase." Biochemical Pharmacology 36, no. 4 (1987): 553–60. http://dx.doi.org/10.1016/0006-2952(87)90366-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Hussein, Abdelaziz M., Hala Abdel Malek, and Mohamed-Ahdy Saad. "Renoprotective effects of aliskiren on adenine-induced tubulointerstitial nephropathy: possible underlying mechanisms." Canadian Journal of Physiology and Pharmacology 94, no. 8 (2016): 829–37. http://dx.doi.org/10.1139/cjpp-2015-0364.

Full text

Abstract:

The present study investigated the possible renoprotective effect of direct renin inhibitor (aliskiren) on renal dysfunctions, as well as its underlying mechanisms in rat model of adenine-induced tubulointerstitial nephropathy. Forty male Sprague-Dawley rats were randomized into 4 groups; normal group, aliskiren group (normal rats received 10 mg/kg aliskiren), adenine group (animals received high-adenine diet for 4 weeks and saline for 12 weeks), and adenine + aliskiren group (animals received adenine for 4 weeks and aliskiren 10 mg/kg for 12 weeks). It was found that adenine caused significan

APA, Harvard, Vancouver, ISO, and other styles

23

Stone, Trevor W. "Receptors for adenosine and adenine nucleotides." General Pharmacology: The Vascular System 22, no. 1 (1991): 25–31. http://dx.doi.org/10.1016/0306-3623(91)90305-p.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Takamasa Kishi, Eishi Kittaka, Sumio Hyodo, et al. "Inhibition by adenine of in vitro immunological functions of normal and adenine phosphoribosyltransferase-deficient human lymphocytes." Immunopharmacology 10, no. 3 (1985): 157–62. http://dx.doi.org/10.1016/0162-3109(85)90021-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Randhawa, Parmjeet, Jiri Zemlicka, Andreas Sauerbrei, et al. "Anti-BK Virus Activity of Nucleoside Analogs." Antimicrobial Agents and Chemotherapy 52, no. 4 (2008): 1519–21. http://dx.doi.org/10.1128/aac.01241-07.

Full text

Abstract:

ABSTRACT Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.

APA, Harvard, Vancouver, ISO, and other styles

26

Pankiewicz, K., L. Chen, R. Petrelli, et al. "Nicotinamide Adenine Dinucleotide Based Therapeutics." Current Medicinal Chemistry 15, no. 7 (2008): 650–70. http://dx.doi.org/10.2174/092986708783885282.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

White, T. D. "Role of adenine compounds in autonomic neurotransmission." Pharmacology & Therapeutics 38, no. 2 (1988): 129–68. http://dx.doi.org/10.1016/0163-7258(88)90095-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Silwal, Prashanta, Kyu Lim, Jun-Young Heo, Jong IL Park, Uk Namgung, and Seung-Kiel Park. "Adenine attenuates lipopolysaccharide-induced inflammatory reactions." Korean Journal of Physiology & Pharmacology 22, no. 4 (2018): 379. http://dx.doi.org/10.4196/kjpp.2018.22.4.379.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Arenas-Jal, Marta, J. M. Suñé-Negre, and Encarna García-Montoya. "Therapeutic potential of nicotinamide adenine dinucleotide (NAD)." European Journal of Pharmacology 879 (July 2020): 173158. http://dx.doi.org/10.1016/j.ejphar.2020.173158.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Fujimori, Hirovuki, Tooru Sasaki, Kivokatsu Hibi, Masaaki Senda, and Masanori Yoshioka. "A method of direct injection of blood samples into an adenine analyser by fluorescent reaction to measure adenine nucleotides." Japanese Journal of Pharmacology 52 (1990): 108. http://dx.doi.org/10.1016/s0021-5198(19)32986-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Hendawy, Fatma, Rabab Hindawy, and Abeer Abdelhameed. "PROTECTIVE EFFECT OF EXOGENOUS REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADPH) ON DOXORUBICIN INDUCED CARDIOTOXICITY IN ADULT ALBINO RATS Fatma Fawzi Hendawy1 Rabab Fawzy Hindawy2, and Abeer A. Abdelhameed1 Pharmacology Department1, and Forensic Medicine & Clinical Toxicology Department2, Faculty of Medicine, Benha University, Egypt." Egyptian Journal of Forensic Sciences and Applied Toxicology 23, no. 2 (2023): 83–99. http://dx.doi.org/10.21608/ejfsat.2023.164695.1272.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Petit, P., M. Manteghetti, R. Puech, and M. M. Loubatieres-Mariani. "ATP and phosphate-modified adenine nucleotide analogues." Biochemical Pharmacology 36, no. 3 (1987): 377–80. http://dx.doi.org/10.1016/0006-2952(87)90297-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Kurahashl, Kazuyoshi, Hiroaki Shirahase, Hachiro Usui, Hisanobu Shimaji, and Motohatsu Fujiwara. "Endothelium-dependent cerebrovascular contraction induced by adenine nucleotides." Japanese Journal of Pharmacology 55 (1991): 29. http://dx.doi.org/10.1016/s0021-5198(19)38135-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Kurahashi, Kazuyoshi, Hiroaki Shirahase, Hachiro Usui, Hisanobu Shimaji, and Motohatsu Fujiwara. "Endothelium-dependent cerebrovascular contraction induced by adenine nucleotides." Japanese Journal of Pharmacology 52 (1990): 48. http://dx.doi.org/10.1016/s0021-5198(19)32921-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Kutryb-Zając, Barbara. "Editorial for the Special Issue Titled “Adenosine Metabolism: Key Targets in Cardiovascular Pharmacology”." Pharmaceuticals 17, no. 6 (2024): 751. http://dx.doi.org/10.3390/ph17060751.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Palmer, Sarah, Robert W. Shafer, and Thomas C. Merigan. "Hydroxyurea Enhances the Activities of Didanosine, 9-[2-(Phosphonylmethoxy)ethyl]adenine, and 9-[2-(Phosphonylmethoxy)propyl]adenine against Drug-Susceptible and Drug-Resistant Human Immunodeficiency Virus Isolates." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 2046–50. http://dx.doi.org/10.1128/aac.43.8.2046.

Full text

Abstract:

ABSTRACT We assessed the effects of hydroxyurea (HU) at a concentration of 50 μM on the in vitro activities of 2′,3′-dideoxyinosine (ddI), 9-[2-(phosphonylmethoxy)ethyl]adenine (PMEA), and 9-[2-(phosphonylmethoxy)propyl]adenine (PMPA) against a wild-type human immunodeficiency virus (HIV) type 1 (HIV-1) laboratory isolate and a panel of five well-characterized drug-resistant HIV isolates. Fifty micromolar HU significantly increased the activities of ddI, PMEA, and PMPA against both the wild-type and the drug-resistant HIV-1 isolates. In fixed combinations, both ddI and PMEA were synergistic wi

APA, Harvard, Vancouver, ISO, and other styles

37

Lam, S. P., F. Devinsky, and J. W. Gorrod. "Biological N-oxidation of adenine and 9-alkyl derivatives." European Journal of Drug Metabolism and Pharmacokinetics 12, no. 4 (1987): 239–43. http://dx.doi.org/10.1007/bf03189906.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Maufrais, Corinne, and Yves Boulard. "Solution structure of a DNA duplex containing a formamide-adenine base pair." Canadian Journal of Physiology and Pharmacology 80, no. 7 (2002): 609–17. http://dx.doi.org/10.1139/y02-068.

Full text

Abstract:

The N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide residue results from a ring fragmentation product of thymine or cytosine. The presence of a formamide-adenine base pair in the sequence 5'd(AGGAACCACG).d(CGTGGFTCCT) has been studied by 1H and 31P nuclear magnetic resonance (NMR) and molecular dynamics. There are two possible isomers for the formamide side chain, either cis or trans. For each isomer, we observed an equilibrium in solution between two forms. First, a species where the formamide is intrahelical and paired with the facing adenine. For the cis isomer, the formamide is in a sy

APA, Harvard, Vancouver, ISO, and other styles

39

Yokozawa, Takako, and Hikokichi Oura. "Increased heparic adenine nucleotide content by ginseng." Journal of Ethnopharmacology 34, no. 1 (1991): 79–82. http://dx.doi.org/10.1016/0378-8741(91)90191-f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Boeynaems, Jean-Marie, Odile Boutherin-Falson, and Sabine Pirotton. "Mechanisms of adenine nucleotides action on vascular endothelial cells." Japanese Journal of Pharmacology 52 (1990): 24. http://dx.doi.org/10.1016/s0021-5198(19)32901-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Ohkubo, Satoko, Isao Matsuoka, and Junko Kimura. "Extracellular metabolism of adenine nucleotides in C6Bu-1 cells." Japanese Journal of Pharmacology 82 (2000): 129. http://dx.doi.org/10.1016/s0021-5198(19)47978-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Li, Yue, Hironobu Sawata, Ikuo Norota, Masao Endoh, and Makoto Endo. "Effects of Adenine on Rat Cardiac Excitation-Contraction Coupling." Japanese Journal of Pharmacology 82 (2000): 148. http://dx.doi.org/10.1016/s0021-5198(19)48055-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Jørgensen, Søren. "Adenine Nucleotides and Oxypurines in Stored Donor Blood." Acta Pharmacologica et Toxicologica 13, no. 1 (2009): 102–6. http://dx.doi.org/10.1111/j.1600-0773.1957.tb00244.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Chalmers, A. H., T. Rotstein, M. Mohan Rao, V. R. Marshall, and M. Coleman. "Studies on the mechanism of immunosuppression with adenine." International Journal of Immunopharmacology 7, no. 4 (1985): 433–42. http://dx.doi.org/10.1016/0192-0561(85)90061-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Hall, Iris H., Bruce S. Burnham, Amy Elkins, et al. "Boronated Pyrimidines and Purines as Cytotoxic, Hypolipidemic and Anti-Inflammatory Agents." Metal-Based Drugs 3, no. 3 (1996): 155–60. http://dx.doi.org/10.1155/mbd.1996.155.

Full text

Abstract:

The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives. Interestingly the boronated acyclovir derivative was a very potent hypolipidemic agent achieving better activity than clofibrate and lovastatin. The boronated adenine derivatives appeared to have the best anti-inflammatory activity in reducing local edema and analgesic effects. The agents were acti

APA, Harvard, Vancouver, ISO, and other styles

46

Aussedat, J., M. Verdys, and A. Rossi. "Adenine nucleotide synthesis from inosine during normoxia and after ischaemia in the isolated perfused rat heart." Canadian Journal of Physiology and Pharmacology 63, no. 9 (1985): 1159–64. http://dx.doi.org/10.1139/y85-190.

Full text

Abstract:

[14C]inosine in a range of concentrations of 20 μM to 1 mM was administered-to the isolated perfused rat heart for 30 min. The incorporation of the nucleoside into myocardial adenine nucleotides increased for extracellular concentrations of the precursor up to 50 μM, reaching a plateau at 60 nmol∙g−1∙30 min−1 with concentrations ranging between 50 and 200 μM. The supply of 500 μM and 1 mM of inosine induced a further increase in cardiac adenine nucleotide synthesis to about 200 nmol∙g−1∙30 min−1. When supplied during low flow ischaemia (0.5 mL∙min−1, 30 min.), 1 mM of inosine protected the hea

APA, Harvard, Vancouver, ISO, and other styles

47

Hambrock, Annette, Cornelia Löffler-Walz, and Ulrich Quast. "Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides." British Journal of Pharmacology 136, no. 7 (2002): 995–1004. http://dx.doi.org/10.1038/sj.bjp.0704801.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Saitoh, Masaji, Masao Moriya, Naoko Murakoshi, Yoshio Shimizu, and Masakazu Nishimura. "Effects of adenosine and adenine on cold acclimation in mice." Folia Pharmacologica Japonica 110, supplement (1997): 183–88. http://dx.doi.org/10.1254/fpj.110.supplement_183.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Asakawa, Takeo, Masako Takano, and Shunji Ariyoshi. "Adenine nucleotide-dependent activation of guanylate cyclase in lung membranes." Japanese Journal of Pharmacology 67 (1995): 256. http://dx.doi.org/10.1016/s0021-5198(19)46988-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Torres, Iraci Lucena S., Cristina Ribas Fürstenau, Gabriela Rossi, et al. "Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum." European Journal of Pharmacology 560, no. 2-3 (2007): 212–15. http://dx.doi.org/10.1016/j.ejphar.2006.12.021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!