Relevant bibliographies by topics / Adrenal steroidogenic enzymes

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Adrenal steroidogenic enzymes'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Adrenal steroidogenic enzymes"

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Baranowski, Elizabeth S., Wiebke Arlt, and Jan Idkowiak. "Monogenic Disorders of Adrenal Steroidogenesis." Hormone Research in Paediatrics 89, no. 5 (2018): 292–310. http://dx.doi.org/10.1159/000488034.

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Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of mineralocorticoids, glucocorticoids, and androgens. This mini review describes the principles of adrenal steroidogenesis, including the newly appreciated 11-oxygenated androgen pathway. This is followed by a description of pathophysiology, biochemistry, and clinical implications of steroidogenic disorders, including mutations affecting cholesterol import and
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Ross, J. T., I. C. McMillen, F. Lok, A. G. Thiel, J. A. Owens, and C. L. Coulter. "Intrafetal Insulin-Like Growth Factor-I Infusion Stimulates Adrenal Growth But Not Steroidogenesis in the Sheep Fetus during Late Gestation." Endocrinology 148, no. 11 (2007): 5424–32. http://dx.doi.org/10.1210/en.2006-1573.

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We investigated the effects of an intrafetal infusion of IGF-I on adrenal growth and expression of the adrenal steroidogenic and catecholamine-synthetic enzyme mRNAs in the sheep fetus during late gestation. Fetal sheep were infused for 10 d with either IGF-I (26 μg/kg·h; n = 14) or saline (n = 10) between 120 and 130 d gestation, and adrenal glands were collected for morphological analysis and determination of the mRNA expression of steroidogenic and catecholamine-synthetic enzymes. Fetal body weight was not altered by IGF-I infusion; however, adrenal weight was significantly increased by 145
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Melau, Cecilie, John Erik Nielsen, Hanne Frederiksen, et al. "Characterization of Human Adrenal Steroidogenesis During Fetal Development." Journal of Clinical Endocrinology & Metabolism 104, no. 5 (2018): 1802–12. http://dx.doi.org/10.1210/jc.2018-01759.

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Abstract Context The endocrine function of human fetal adrenals (HFAs) is activated already during first trimester, but adrenal steroidogenesis during fetal life is not well characterized. Objective This study aimed to investigate HFA steroidogenesis by analyzing adrenal glands from first and second trimesters. Design and Setting Male and female HFA from gestational weeks (GWs) 8 to 19 were examined, including a total of 101 samples from 83 fetuses. Main Outcome Measure(s) Expression level of steroidogenic genes and protein expression/localization were determined by quantitative PCR and immuno
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Parker, Keith L., and Bernard P. Schimmer. "Transcriptional regulation of the adrenal steroidogenic enzymes." Trends in Endocrinology & Metabolism 4, no. 2 (1993): 46–50. http://dx.doi.org/10.1016/s1043-2760(05)80014-1.

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Lottrup, Grete, John E. Nielsen, Niels E. Skakkebæk, Anders Juul, and Ewa Rajpert-De Meyts. "Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours." European Journal of Endocrinology 172, no. 4 (2015): 491–99. http://dx.doi.org/10.1530/eje-14-0810.

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ObjectiveTesticular adrenal rest tumours (TARTs) are a common finding in patients with congenital adrenal hyperplasia (CAH). These tumours constitute a diagnostic and management conundrum and may lead to infertility. TART cells share many functional and morphological similarities with Leydig cells (LCs), and masses consisting of such cells are occasionally misclassified as malignant testicular tumours, which may lead to erroneous orchiectomy in these patients.DesignIn this study, we aimed to investigate the potential of LC developmental markers and adrenal steroidogenic markers in the differen
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Couzinet, Beatrice, Geri Meduri, Maria G. Lecce, et al. "The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 5060–66. http://dx.doi.org/10.1210/jcem.86.10.7900.

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It is currently believed that the postmenopausal ovary remains a gonadotropin-driven, androgen-producing gland. However, the adrenal contribution to circulating androgen levels may explain some conflicting results previously reported. In addition, the steroidogenic potential and gonadotropin responsiveness of the postmenopausal ovary have not been recently reassessed. Plasma T, bioavailable T, free T, androstenedione (Adione), and dehydroepiandrosterone sulfate levels were measured in postmenopausal or ovariectomized women with complete adrenal insufficiency, compared with women with intact ad
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Lundqvist, Johan. "Vitamin D as a regulator of steroidogenic enzymes." F1000Research 3 (July 8, 2014): 155. http://dx.doi.org/10.12688/f1000research.4714.1.

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During the last decades, the outlook on vitamin D has widened, from being a vitamin solely involved in bone metabolism and calcium homeostasis, to being a multifunctional hormone known to affect a broad range of physiological processes. The aim of this review is to summarize the research on vitamin D as a regulator of steroidogenic enzymes. Steroid hormones exert a wide range of physiological responses, including functions in the immune system, protein and carbohydrate metabolism, water and salt balance, reproductive system and development of sexual characteristics. The balance of sex hormones
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Saito, Ryuta, Natsuko Terasaki, Makoto Yamazaki, Naoya Masutomi, Naohisa Tsutsui, and Masahiro Okamoto. "Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells." Journal of Toxicology 2016 (2016): 1–19. http://dx.doi.org/10.1155/2016/4041827.

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Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of steroidogenesis in human adrenocortical carcinoma NCI-H295R cells. The model includes cellular proliferation, intracellular cholesterol translocation, diffusional transport of steroids, and metabolic pathways of adrenal steroidogenesis, which serially involve steroidogenic proteins and enzymes such as StAR, CYP11A1, CYP17A1,
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Provencher, P. H., Y. Tremblay, B. Belanger, and A. Belanger. "Studies of adrenal steroidogenic enzymes in guinea pigs." American Journal of Physiology-Endocrinology and Metabolism 262, no. 6 (1992): E869—E874. http://dx.doi.org/10.1152/ajpendo.1992.262.6.e869.

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In the present study we found that 3 beta-hydroxysteroid dehydrogenase 4-ene-5-ene-isomerase (3 beta-HSD), 17-hydroxylase and 17,20-lyase (P-450c17), and 21-hydroxylase (P-450c21) activities in a suspension of cells from guinea pig zona reticularis (RE) were 10- to 15-fold less than those measured in cells from zona fasciculata-glomerulosa (FG). Whereas the secretion of cortisol and C-19 steroids was remarkably increased during treatment of FG cells with adrenocorticotropic hormone (ACTH), no response could be detected when using cells from zona RE. By contrast, the measurement of a series of
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Suda, Noriko, Hirotaka Shibata, Isao Kurihara, et al. "Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS1." Endocrinology 152, no. 6 (2011): 2266–77. http://dx.doi.org/10.1210/en.2010-1232.

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Steroidogenic factor-1 (SF-1) is a nuclear orphan receptor, which is essential for adrenal development and regulation of steroidogenic enzyme expression. SF-1 is posttranslationally modified by small ubiquitin-related modifier-1 (SUMO-1), thus mostly resulting in attenuation of transcription. We investigated the role of sumoylation enzymes, Ubc9 and protein inhibitors of activated STAT1 (PIAS1), in SF-1-mediated transcription of steroidogenic enzyme genes in the adrenal cortex. Coimmunoprecipitation assays showed that both Ubc9 and PIAS1 interacted with SF-1. Transient transfection assays in a
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Dissertations / Theses on the topic "Adrenal steroidogenic enzymes"

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Lo, Yi-Chen. "The regulation of steroidogenic enzymes in rat adrenal gland." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24856.

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Functional zonation of the rat adrenal cortex may be defined by the expression of the mitochondrial enzymes aldosterone synthase (CYP11B2) and 11 (3-hydroxylase (CYP11B1) that regulate the secretion of the steroids aldosterone in the zona glomerulosa (ZG) and corticosterone in the zona fasciculata (ZF), respectively. Synthesis of these steroids is also dependent on steroidogenic acute regulatory (StAR) protein which limits the transport of cholesterol into the mitochondria. The main aims of this thesis were to study the distribution and expression of CYP11B2 and CYP11B1 in the adrenal cortex o
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Perold, Helene. "The influence of Rooibos (Aspalathus linearis) on adrenal steroidogenic P450 enzymes." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2381.

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Thesis (MSc (Biochemistry))--University of Stellenbosch, 2009.<br>This study: 1. Describes the preparation of unfermented and fermented rooibos methanol and aqueous extracts. 2. Investigates the influence of unfermented and fermented rooibos methanol and aqueous extracts on the binding of natural steroid substrates to ovine adrenal microsomal cytochrome P450 enzymes, demonstrating that the binding of natural steroids is inhibited in the presence of rooibos extracts. 3. Describes an assay demonstrating the inhibitory effect of rooibos extracts on the catalytic activity of cytochrome 17α
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De, Silva Matharage Shenali. "Involvement of AMPK and AP-1 Biochemical Pathways in IL-6 Regulation of Steroidogenic Enzymes in the Adrenal Cortex." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4301.

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The adrenal cortex is a crucial endocrine gland in the mammalian stress response. In chronic inflammatory stress, cortisol is elevated whereas adrenal androgens are decreased. Furthermore, ACTH levels have poor correlation with the plasma cortisol in these conditions, thus suggesting that other factors are driving the stress response during chronic inflammatory stress. Interleukin-6 (IL-6), a cytokine which is released during chronic inflammatory stress, is assumed to be one such factor. Thus the biochemical pathways by which IL-6 increases cortisol release from the zona fasciculata (ZF), and
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Schloms, Lindie. "The inhibition of adrenal steroidogenic enzymes and modulation of glucocorticoid levels in vitro and in vivo by aspalathus linearis (rooibos)." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97000.

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Thesis (PhD)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: This study describes: • the influence of a methanolic extract of unfermented Rooibos and five major Rooibos flavonoids, aspalathin, nothofagin, rutin, orientin and vitexin, on the activities of key adrenal steroidogenic enzymes - cytochrome P450 17β- hydroxylase/17,20-lyase (CYP17A1), 3β-hydroxysteroid dehydrogenase • the development of a novel UPLC-MS/MS method for the separation and quantification of 21 adrenal steroid metabolites; • the influence of Rooibos and aforementioned flavonoids on adrenal steroid hormone prod
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Book chapters on the topic "Adrenal steroidogenic enzymes"

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Miller, Walter L. "Steroidogenic Enzymes." In Disorders of the Human Adrenal Cortex. KARGER, 2008. http://dx.doi.org/10.1159/000134751.

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Krone, Nils. "Congenital adrenal hyperplasia." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.0616.

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Congenital adrenal hyperplasia (CAH) represents a group of autosomal recessive disorders of steroidogenesis caused by defects in steroidogenic enzymes involved in glucocorticoid synthesis or in enzymes providing cofactors to steroidogenic enzymes (1, 2). Congenital lipoid adrenal hyperplasia (CLAH) caused by steroidogenic acute regulatory protein (StAR) deficiency is distinct in origin and presentation from the conventional variants of CAH, with the unique feature of lipid accumulation subsequently leading to destruction of adrenal function. This chapter will also mention aldosterone synthase deficiency, which is the only defect in adrenal steroidogenesis causing deficient mineralocorticoid biosynthesis without affecting glucocorticoid biosynthesis. The disorder cannot strictly be considered a CAH variant as it does not result in increased ACTH drive and thus not in adrenal hyperplasia. Novel forms of CAH have emerged during recent years. These include P450 oxidoreductase deficiency (ORD), P450 side-chain cleavage (CYP11A1) deficiency, the nonclassic form of CLAH (StAR deficiency), and apparent cortisone reductase deficiency. All forms of congenital adrenal hyperplasia resemble a disease continuum spanning from mild nonclassic presentations to classic onset with severe signs and symptoms.
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BETTERLE, CORRADO, RENATO ZANCHETTA, SHU CHEN, and JADWIGA FURMANIAK. "ANTIBODIES TO ADRENAL, GONADAL TISSUES AND STEROIDOGENIC ENZYMES." In Autoantibodies. Elsevier, 2007. http://dx.doi.org/10.1016/b978-044452763-9/50054-8.

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"Adrenocortical Toxicology In Vitro: Assessment of Steroidogenic Enzyme Expression and Steroid Production in H295R Cells." In Adrenal Toxicology. CRC Press, 2008. http://dx.doi.org/10.3109/9781420061307-11.

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Brutsaert, Erika F., Hironobu Sasano, Pamela Unger, Mary Beasley, Maria New, and Alice C. Levine. "Immunohistochemical Analysis of Steroidogenic Enzyme Expression in Adrenal Cortical Carcinoma Pulmonary Metastases Causing Cushing Syndrome." In CLINICAL - Adrenal Tumor Cases. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p11.p2-662.

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Wang, T., F. Satoh, R. Morimoto, Y. Nakamura, H. Sasano, and WE Rainey. "Steroidogenic Enzyme Transcript Levels in Aldosterone-Producing Adenomas and Adjacent Normal Adrenal Tissue." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part2.p13.p2-636.

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Journal articles
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