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Dissertations / Theses on the topic 'Adrenergic stress'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Camp, Robert M. "Effect of Chronic Stress Exposure on Beta-adrenergic Receptor Signaling and Fear- Learning." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1449576849.

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2

Manion, Sean T. "Amygdala, anxiety & alpha-1 adrenoreceptors : investigations utilizing a rodent model of traumatic stress /." Download the thesis in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/Manion2006.pdf.

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Dalal, Suman, Cerrone R. Foster, Bhudev C. Das, Mahipal Singh та Krishna Singh. "β-Adrenergic Receptor Stimulation Induces Endoplasmic Reticulum Stress in Adult Cardiac Myocytes: Role in Apoptosis". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/8572.

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Accumulation of misfolded proteins and alterations in calcium homeostasis induces endoplasmic reticulum (ER) stress, leading to apoptosis. In this study, we tested the hypothesis that β-AR stimulation induces ER stress, and induction of ER stress plays a pro-apoptotic role in cardiac myocytes. Using thapsigargin and brefeldin A, we demonstrate that ER stress induces apoptosis in adult rat ventricular myocytes (ARVMs). β-AR-stimulation (isoproterenol; 3h) significantly increased expression of ER stress proteins, such as GRP-78, Gadd-153, and Gadd-34, while activating caspase-12 in ARVMs. In mos

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4

Nagabhushan, Sahana. "Neural Mechanisms Underlying Stress-Induced Depression and Its Prevention." Kent State University Honors College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304462392.

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5

Hagenmaier, Jacob Andrew. "Investigation into an ongoing dilemma: undefined welfare implications challenging the use of β-adrenergic agonists in beef production". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/35217.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Daniel U. Thomson<br>Beta-adrenergic agonists (βAA) are administered during the final weeks of the beef production system to improve efficiency and increase meat yield. Welfare concerns linked to the administration of βAA have garnered significant attention in recent years due to anecdotal reports of increased mortality during βAA feeding periods and cattle without obvious disease or injury having difficulty walking at abattoirs being overrepresented in cattle fed βAA. Thomson et al. (2015) reported 2 events where cattle

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6

Chen, Xiaochuan, Amy C. Kelly, Dustin T. Yates, Antoni R. Macko, Ronald M. Lynch, and Sean W. Limesand. "Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine." BIOSCIENTIFICA LTD, 2017. http://hdl.handle.net/10150/623222.

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Complications in pregnancy elevate fetal norepinephrine (NE) concentrations. Previous studies in NE-infused sheep fetuses revealed that sustained exposure to high NE resulted in lower expression of α2-adrenergic receptors in islets and increased insulin secretion responsiveness after acutely terminating the NE infusion. In this study, we determined if the compensatory increase in insulin secretion after chronic elevation of NE is independent of hyperglycemia in sheep fetuses and whether it is persistent in conjunction with islet desensitization to NE. After an initial assessment of glucose-sti

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7

Zhang, Xiaobin. "Generalized anxiety disorder in the elderly : role of bio-environmental factors and genetic vulnerability." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT036/document.

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Le trouble anxieux généralisé (TAG) est un problème majeur de santé publique. Il est fréquemment sous ou mal diagnostiqué, notamment chez les personnes âgées. Il est souvent comorbide et source d’incapacité et présente un faible taux de rémission complète. Malgré des conséquences socio-économiques et sanitaires importantes, les recherches sur les déterminants du TAG en population générale âgée restent limitées. L'objectif de cette thèse était d’étudier les caractéristiques cliniques et étiologiques du TAG à partir de l'étude prospective ESPRIT, constituée de 2259 personnes âgées de 65 ans et p

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8

Reader, Brenda Faye. "Social Stress Induces Immunoenhancement During Allergic Airway Inflammation and Infection." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385475903.

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9

Calderón, Diego Mauricio Bravo. "Expressão de receptor beta-2 adrenérgico em carcinoma espinocelular de boca e sua associação com a evolução clínica tumoral." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-27072011-095304/.

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Os hormônios produzidos durante o estresse e seus receptores específicos têm sido amplamente envolvidos com a progressão do câncer. O objetivo deste estudo foi avaliar a expressão dos receptores β2 adrenérgicos pelas células malignas de carcinomas espinocelulares de boca (CEC) e sua correlação com as a características clínicas, evolução e o prognóstico dos pacientes. Um total de 106 pacientes portadores de CEC de boca em estádios clínicos II, III e IV, tratados no Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do Hospital de Câncer A.C. Camargo, São Paulo, Brasil, no

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10

Karimigalougahi, Keyvan. "Redox regulation of eNOS and Na+-K+ pump: therapeutic implications in diabetes." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12135.

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Background: Oxidative stress is central in pathobiology of many diseases. The focus of this Thesis is on oxidative mechanisms involved in signaling through angiotensin II (Ang II)- and beta-1 adrenergic receptors (ARs), and their effects on the membrane proteins endothelial nitric oxide synthase (eNOS) and Na+-K+ pump in cardiovascular system. The redox mechanism investigated was glutathionylation, a reversible modification of cysteines, with effects on proteins similar to phosphorylation. As the final aim, we examined the effects of beta-3 AR stimulation on redox pathways and membrane protein

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11

Modiri, Ali-Reza. "Functional Models in the Search for Pharmacological Treatment of Urinary Incontinence : The Role of Adrenergic, Cholinergic, and Serotonergic Receptors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5278-7/.

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12

Alam, Sabikha. "Cross-talk of retinoic acid and adrenergic hormone signaling may influence development of cardiac conduction and rhythmicity in utero." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/11.

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Stress hormones, adrenaline and noradrenaline, have been shown to be critical for heart development. Mice lacking dopamine greek lower case letter beta]-hydroxylase (Dbh), an enzyme responsible for synthesis of these adrenergic hormones, die during mid-gestation due to cardiac failure. Prior research showed that adrenergic cells are found within the electrical conduction system of the heart, and adrenergic deficiency leads to slowed cardiac conduction during embryogenesis. Microarray analysis of wild-type (Dbh⁺/⁺) and knockout (Dbh⁻/⁻) mouse hearts revealed significant differences in expressio

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13

Ana, Yuliana. "Study on the regulatory mechanism for Uncoupling protein 1 (Ucp1) expression in beige adipocytes." Kyoto University, 2019. http://hdl.handle.net/2433/244554.

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14

Miller, Roxanne M. "Pharmaceutical and Natural (Exercise) Mechanisms to Mitigate the Negative Impact of PTSD and Chronic Stress on Synaptic Plasticity and Memory." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7242.

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Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing chan

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15

Calderón, Diego Mauricio Bravo. "Migração e invasão do câncer de boca via ativação de receptor beta 2 adrenérgico por mediador do estresse." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-10032016-163155/.

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A ativação do receptor beta 2 adrenérgico (β2-AR), pelos mediadores químicos do estresse, pode induzir efeitos estimuladores ou inibidores na migração e invasão celular, dependendo do tipo de tumor maligno. A importância deste receptor na evolução do câncer de boca não está totalmente esclarecida. O objetivo deste estudo foi verificar a expressão do β2-AR em linhagens de carcinomas espinocelular de boca (SCC-9 e SCC-25), e investigar o papel da ativação deste receptor pela norepinefrina e de seu bloqueio por um antagonista na migração e invasão destas células neoplásicas. As célul

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16

Grogan, Shawn Patrick, of Western Sydney Hawkesbury University, Faculty of Environmental Management and Agriculture, and School of Agriculture and Rural Development. "Endocrine alteration of meat quality and gene expression in rats and deer." THESIS_FEMA_ARD_Grogan_S.xml, 1998. http://handle.uws.edu.au:8081/1959.7/724.

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Stress activates a number of endocrine pathways that alter an animal's physiology in a manner which can result in undesirable meat quality. Animals frequently exhibit meat quality defects, including ecchymosis, at slaughter due to the stress of slaughter. This thesis explores how stress related hormones interact with adrenergic receptors to alter muscle and vascular physiology. Fallow deer were exposed to either a transciptional regulator (hydrocortisone), a beta adrenergic recptor agonist (clenbuterol) or a beta adrenergic receptor antagonist (propranolol). The administration of hydrocortison

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17

Grogan, Shawn Patrick. "Endocrine alteration of meat quality and gene expression in rats and deer." Thesis, [Richmond, N.S.W.] : CSIRO Animal Production : School of Agriculture, University of Western Sydney, Hawkesbury, 1998. http://handle.uws.edu.au:8081/1959.7/724.

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Stress activates a number of endocrine pathways that alter an animal's physiology in a manner which can result in undesirable meat quality. Animals frequently exhibit meat quality defects, including ecchymosis, at slaughter due to the stress of slaughter. This thesis explores how stress related hormones interact with adrenergic receptors to alter muscle and vascular physiology. Fallow deer were exposed to either a transciptional regulator (hydrocortisone), a beta adrenergic recptor agonist (clenbuterol) or a beta adrenergic receptor antagonist (propranolol). The administration of hydrocortison

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18

Vilardi, Bruna Maria Rodrigues. "Modulação da expressão de VEGF-C por mediador relacionado ao estresse em culturas de carcinomas espinocelulares de boca." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-13072011-164007/.

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Os mediadores do estresse, epinefrina e norepinefrina, participam da modulação de diversos processos celulares como a proliferação, a migração celular e a apoptose durante a tumorigênese, influenciando assim, o crescimento e a progressão tumoral. A presença de receptores beta-adrenérgicos e sua expressiva resposta ao estímulo do neurohormônio norepinefrina foram identificadas em várias linhagens de células tumorais, incluindo o carcinoma espinocelular de boca. O objetivo deste estudo foi investigar a influência da norepinefrina na expressão do fator de crescimento endotelial vascular do tipo C

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19

Perfetti, Juliano Genaro. "Bloqueio dos receptores β1 - adrenérgicos periféricos impede o desenvolvimento da ansiedade tardia induzida por estresse em ratos Wistar." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-08092016-093352/.

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INTRODUÇÃO: o estresse, causa importante de ansiedade, provoca ativação do eixo HPA, liberando hormônios glicocorticoides e adrenalina, e neurotransmissores, como a norepinefrina. Consequentemente, ocorrem mudanças morfológicas e biomoleculares em diversas regiões do SNC, destacando-se o complexo basolateral da amígdala, além de alterações comportamentais. OBJETIVOS: investigar, por meio de administrações (ip) de atenolol e metirapona, possíveis influências periféricas dos receptores de NE (β1) e GR no BLA de ratos na ansiedade tardia. Analisar também a via de sinalização intracelular E

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20

Rodrigues, Aurora Corrêa. "Efeitos do treinamento físico sobre as propriedades morfológicas e mecânicas em cardiomiócitos de camundongos knockout para os receptores β1- e β2-adrenérgicos". Universidade Federal de Viçosa, 2014. http://locus.ufv.br/handle/123456789/3496.

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Made available in DSpace on 2015-03-26T13:22:04Z (GMT). No. of bitstreams: 1 text completo.pdf: 757671 bytes, checksum: 435de7db4aaa7b1bdaf1bc5260f57dd9 (MD5) Previous issue date: 2014-03-11<br>O objetivo do presente estudo foi investigar os efeitos do treinamento físico sobre as propriedades morfológicas e mecânicas de cardiomiócitos de camundongos knockout (KO) para receptores os β1- e β2 adrenérgicos. Camundongos C57BL/6J, KO para os receptores β1-adrenérgicos, FVB/N e KO para os receptores β2-adrenérgicos com 4 meses de idade, foram inicialmente separados aleatoriamente em 8 grupos: C5

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21

Petkevicius, Kasparas. "The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/285429.

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Obesity-associated metabolic disorders are amongst the most prevalent causes of death worldwide. Understanding how obesity leads to the development of the Metabolic Syndrome (MetS) and cardiovascular disease (CVD) will enable the development of novel therapies that dissociate obesity from its cardiometabolic complications. Our laboratory views the functional capacity of white adipose tissue (WAT), the organ designed for safe lipid storage, as a key factor in the development of MetS and CVD. At a genetically-defined stage of the aberrant WAT expansion that occurs during obesity, adipocytes unde

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22

Tanno, Ana Paula. "Influencia do ciclo estral sobre as alterações de sensibilidade adrenergica induzidas por estresse agudo." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288846.

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Orientador: Fernanda Klein Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-01T15:52:30Z (GMT). No. of bitstreams: 1 Tanno_AnaPaula_M.pdf: 2309126 bytes, checksum: dbb3c3a796d6795d34bddff7378b218b (MD5) Previous issue date: 2002<br>Resumo: o estresse pode alterar a sensibilidade de vários tecidos às catecolaminas. O objetivo deste estudo foi avaliar a sensibilidade à noradrenalina e adrenalina de átrios direitos de ratas submetidas ao estresse agudo, em diferentes fases do ciclo estral. Rata

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23

MARIANI, RAFFAELLA. "Il sovraccarico di ferro: modulatore della risposta adrenergica." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7470.

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Adrenergic vascular hyper-responsiveness is a hallmark of different cardiometabolic disease, including essential hypertension, diabetes, obesity, metabolic syndrome, heart failure and chronic kidney disease. Previous studies have shown that sympathetic activation and insulin resistance are closely related each other, but the cause-and-effect relationship remains undefined. Iron overload impairs glucose metabolism in hemochromatosis patients by either insulin resistance or decreased insulin secretion. There are no data on the effect of iron overload on the adrenergic overdrive. The study group

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24

Rumball, Freya. "Studying individual differences and emotion regulation effects on PTSD-like responding and recovery : a psychophysiological VR-trauma paradigm." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14171.

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Despite a high proportion of the population experiencing traumatic events within their lifetime, the number of individuals who go on to develop posttraumatic stress disorder (PTSD) is comparatively small; herein highlighting the importance of individual differences in imparting risk and resilience towards the development and maintenance of PTSD. Existing literature illustrates that biological and ecological factors are important in predicting PTSD development, with pathological vulnerabilities excepting their effects at pre- peri- and post trauma stages. Whilst cognitive and emotion based mode

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25

Moura, Andre Luiz de. "Sensibilidade a agonistas [beta]-adrenergicos em atrio esquerdo isolado de ratos submetidos a estresse." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314622.

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Orientadores: Regina Celia Spadari-Bratfisch, Dora Maria Grassi-Kassisse<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-02T14:08:15Z (GMT). No. of bitstreams: 1 Moura_AndreLuizde_M.pdf: 4831255 bytes, checksum: 89a79fa25a0a6831c383781d8adbb2ce (MD5) Previous issue date: 2002<br>Resumo: O estresse por choque nas patas promove supersensibilidade ao efeito cronotrópico positivo da isoprenalina em átrios direitos isolados de ratos e ratas sacrificadas em diestro, a qual está associada a aumento da proteína do adrenocept

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26

Verago, Josiane Lombardi. "Concentrações plasmaticas de corticosterona, glicose, glicerol e triacilglicerois em resposta a infusão de agonistas beta-adrenergicos em ratos submetidos a estresse por choque nas patas." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314628.

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Orientador: Regina Celia Spadari-Bratfisch<br>Dissertação (mestrado) - Universidade estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-25T21:41:07Z (GMT). No. of bitstreams: 1 Verago_JosianeLombardi_M.pdf: 2480631 bytes, checksum: c9bc11f0d37c318d249e64047243f35b (MD5) Previous issue date: 2000<br>Resumo: No estresse observa-se a elevação das concentrações plasmáticas de hormônios tais como as catecolaminas, os glicocorticóides e o glucagon. Estes hormônios determinam alterações em funções metabólicas, entre elas as que ocorrem em tecido adiposo, estimulando a

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27

Hoppmann, Uta [Verfasser]. "Einfluss von sozialem Stress auf das Neuropeptid Y- Dipeptidylpeptidase 4-System und die sympathiko–adrenerge- medulläre-Achse bei Patienten mit koronarer Herzerkrankung und depressiver Komorbidität / Uta Hoppmann." Ulm : Universität Ulm, 2018. http://d-nb.info/1150781068/34.

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28

Silva, Dany. "Adrenergic contribution to the stress induced carcinogenesis." Master's thesis, 2019. https://hdl.handle.net/10216/125337.

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Silva, Dany. "Adrenergic contribution to the stress induced carcinogenesis." Dissertação, 2019. https://hdl.handle.net/10216/125337.

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30

Kuo, Chung-Hsun, and 郭忠訓. "Blockage of ß-adrenergic Receptors Reduces the Odds of Stress-induced Learned Helplessness." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/16084384978386973544.

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碩士<br>國立陽明大學<br>腦科學研究所<br>98<br>Background: When animals are under stress, norepinephrine in their bodies surges to activate the sympathetic nervous system (SNS) via the ß-adrenergic receptors (ß-AR). Increased norepinephrine can help animals to handle stress, but may as well cause anxiety, tension, fear, and impair attention when the SNS is over-activated. Although over-activated SNS can be tempered by ß-AR antagonists, like propranolol, which is believed may disturb memory formation. This study explored the mechanism of propranolol’s effects on learned helplessness which is similar to stres

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31

Silva, Cátia Marisa Soares 1990. "Role of β-adrenergic signaling in ovarian cancer cells biology". Master's thesis, 2014. http://hdl.handle.net/10451/15381.

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Tese de mestrado. Biologia (Biologia Evolutiva e do Desenvolvimento). Universidade de Lisboa, Faculdade de Ciências, 2014<br>Human ovarian cancer is the seventh most common tumour in women worldwide and the leading cause of death from gynaecological cancers. Nowadays, there is strong evidence that stress affect cancer progression and patient survival. However, the underlying mechanisms of this association are poorly understood. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are released in response to stress, exerting their effects through interaction with adrenergic receptor

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32

Vítková, Ivana. "Vliv akutního chladu a stálého světla na levou komoru srdce potkana." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388455.

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Acute cold exposure increases the risk of sudden cardiac events, similarly exposure to constant light negatively affects the cardiovascular system. However, the individual effects of these factors and the effect of their combination on cardiomyocytes are not yet known. The thesis deals with the influence of a 3 day cold exposure and constant light on the expression of β-adrenergic receptors and associated G-proteins in association with apoptotic signals in the left ventricle of the Wistar rat heart. In this work apoptotic proteins BAX, BCL2, caspase 8 and important components of β-adrenergic s

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Nováková, Martina. "Vlastnosti a regulace muskarinových a adrenergních receptorů Podtitul:Působení stresu na vlastnosti muskarinových a adrenergních receptorů v plicích a srdci." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-312076.

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The aim of this thesis was to clarify the influence of the stress on the adrenergic and muscarinic receptors in the heart and in the lungs. Research was perform on rat hearts and lungs and on the hearts and lungs of the CRH KO mice. First, we assessed mRNA levels of all α- and β-adrenergic receptor and muscarinic receptor subtypes. Subsequently, we performed the radioligand-binding studies to determine densities of these receptors. We identified all three α1-adrenergic receptor subtypes in the rat lungs. In the lungs of WT mice, we found that the amount of α1-adrenergic and muscarinic receptor

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Christians, Claus. "Die Genregulation des myokardialen Na+/Ca2+-Austauschers." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BBE7-C.

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Die Regulation der Expression des myokardialen Na+/Ca2+-Austauschers spielt eine entscheidende Rolle in der Genese von kontraktiler Dysfunktion und Arrhythmie bei der Herzinsuffizienz. Ein besseres Verständnis dieser Regulationsprozesse könnte neue Angriffspunkte für Präventions- und Therapiestrategien liefern. In der vorliegenden Arbeit wurden die Effekte von α1-adrenerger-Stimulation und mechanischer Last, auf die mRNA-Transkription des NCX 1-Gens und weiterer Gene des Kalziumtransportes untersucht. Es wurden elektrisch stimulierte (1 Hz, 1,75 mmol/l Ca2+, optimale Vorlast), rechtsventrikulä

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