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Dissertations / Theses on the topic 'Alcoholic Liver cirrhosis'

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1

Stokkeland, Knut. "Studies on alcoholic liver disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-853-3/.

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2

Le, Moine Olivier. "Interleukin-10 in liver ischaemia-reperfusion injury and alcoholic cirrhosis." Doctoral thesis, Universite Libre de Bruxelles, 1996. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212296.

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3

Gunnarsdóttir, Steingerður Anna /. "Liver cirrhosis : epidemiological and clinical aspects /." Göteborg : Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg University, 2008. http://hdl.handle.net/2077/10132.

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4

Virstiuk, N. O., I. Kobitovuch, Nataliia Oleksyivna Slyvka, and O. V. Virstiuk. "N-terminal pro-brain natriuretic peptide and prognosis of alcoholic liver cirrhosis course." Thesis, The international liver congress. - Barselona, Spain, 13-17.04.2016, 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/11745.

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5

Satishchandran, Abhishek. "The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/838.

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Chronic alcohol use results in accelerated liver injury, leading to alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. However, due to the complex nature of this disease process, a central, druggable mechanism has remained elusive. microRNAs are potent post-transcriptional regulators of gene expression. A single miRNA has the ability to regulate hundreds of pathways simultaneously, defining cellular fate and function. microRNA-122 (miR-122), the most abundant miRNA in hepatocytes, has a demonstrated role as an tumor suppressor, regulator of hepatocyte metabolism, and hepatic d
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Satishchandran, Abhishek. "The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/838.

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Chronic alcohol use results in accelerated liver injury, leading to alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. However, due to the complex nature of this disease process, a central, druggable mechanism has remained elusive. microRNAs are potent post-transcriptional regulators of gene expression. A single miRNA has the ability to regulate hundreds of pathways simultaneously, defining cellular fate and function. microRNA-122 (miR-122), the most abundant miRNA in hepatocytes, has a demonstrated role as an tumor suppressor, regulator of hepatocyte metabolism, and hepatic d
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7

Fassnacht, Ryan. "Molecular Mechanisms Involved Involved in the Interaction Effects of HCV and Ethanol on Liver Cirrhosis." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2246.

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The leading causes of liver disease are Hepatitis C virus infection and chronic alcohol abuse. Alcohol accelerates liver disease in HCV but the mechanisms are poorly understood. The identification of molecular gene expression profiles on human liver tissue was performed using microarrays. Samples were obtained from alcoholic-cirrhotic, HCV-cirrhotic, HCV/alcohol-cirrhotic and control non-cirrhotic liver tissue. Probe set expression summaries were calculated using RMA. Probe set level linear models were fit where probe set expression was modeled by HCV status, alcohol status, and the interactio
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8

Slyvka, N. O., N. G. Virstiuk, I. A. Plesh, and V. A. Gaidukov. "Low cardiac output predicts development of hepatorenal syndrome and survival in patients with alcoholic liver cirrhosis." Thesis, Матерiали 97-ї пiдсумковоi' наукової конференцiї професорсько-викладацького персоналу вищого державного навчального закладу України «Буковинський державний медичний унiверситет» (Чернiвцi, 15, 17 ,22 лютого 2016 р.) - Чернiвцi: Медунiверситет, 2016, 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10380.

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9

Kruger, F. C. "A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1415.

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Thesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008.<br>Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, extending from steatosis (FLD) to steatohepatitis (NASH). Differentiation between NASH and nonprogressive NAFLD is difficult on clinical grounds therefore a need exists to identify reliable biomarkers of disease progression. The aims of the study were 1) to describe the disease profile of NAFLD/NASH in South African patients of the Western Cape, 2) to investigate the metabolic derangements associated with
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10

Trepo, Eric. "Role of genetic factors in the progression of fibrosis in alcoholic liver disease and chronic hepatitis C." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209659.

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La maladie alcoolique du foie (MAF) et l’hépatite C chronique (HCC) sont les causes les plus fréquentes de cirrhose, carcinome hépatocellulaire (CHC) et transplantation hépatique dans les pays industrialisés. La fibrose hépatique est le stigmate lésionnel de la progression de la maladie vers la cirrhose comme dans toutes les hépatopathies chroniques. Certains facteurs de risque cliniques environnementaux ont été identifiés. Toutefois, ils n’expliquent pas l’extrême variabilité individuelle de la progression de la fibrose. L’influence ethnique à développer une maladie plus sévère ainsi que les
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11

Munteanu, Mona. "Performances pronostiques du FibroTest chez les sujets avec maladie métabolique du foie Long‐term prognostic value of the FibroTest in patients with non‐alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS591.

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Le FibroTest (Brevet APHP-Sorbonne Université) est un marqueur quantitatif de la sévérité de la fibrose, largement validé chez les sujets avec les quatre maladies chroniques les plus fréquentes: les hépatites chroniques C et B, la maladie alcoolique du foie et la stéatose non alcoolique du foie (NAFLD). Sa valeur pronostique pour la prédiction des décès liés au foie a également été validée dans ces maladies à l'exception de la NAFLD, probablement en raison de la progression plus lente de la fibrose, et du fait de la plus grande fréquence des décès d'origine extra-hépatique et la plus faible in
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12

McCann, Jennifer Laura. "Comparing Indices of Diet Quality and Nutrient Intakes in Patients with Varying Stages of Non-alcoholic Fatty Liver Disease Utilizing a Web-based 90-day Food Frequency Questionnaire." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555421355382894.

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13

Lemmers, Arnaud. "Transition de l'immunité innée à l'immunité adaptative au cours des maladies chroniques du foie: implication de l'axe "Pattern recognition" récepteurs - Interleukine-6-Th17." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210331.

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La muqueuse intestinale puis le foie sont en contact récurrent avec la flore microbienne issue du tube digestif. L’activation des récepteurs reconnaissant des motifs moléculaires microbiens (PRR :Pattern Recognition Receptors) constitue l’élément initial de la réponse inflammatoire de l’immunité innée et oriente le type d’activation de l’immunité adaptative. La première étape entraînera l’expression de médiateurs inflammatoire (cytokines (IL-1, IL-6, TNFα), activation de la réponse de phase aiguë) et le recrutement des cellules effectrices de l’immunité innée (neutrophiles, puis monocytes). L’
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14

Yang, Jie. "Identification of new genetic determinants that predispose to hepatocellular carcinomas." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7156.

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Le carcinome hépatocellulaire (CHC) est l’un des cancers les plus répandus et les plus meurtriers au monde. Dans le contexte des maladies chroniques du foie, les déterminants génétiques jouent un rôle important dans le développement du CHC. Jusqu'à présent, peu de polymorphismes mononucléotidiques (SNPs) ont été associés de manière reproductible au CHC. Le but de mon projet est d’identifier des marqueurs génétiques prédictif de la survenue du CHC.Par l’étude de cas/témoins, nous avons testé l'association entre une sélection de SNPs et la survenue du CHC, en fonction de l’étiologie et la gravit
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15

Željka, Savić. "Uticaj statusa vitamina D na metaboličku aktivnost kosti i koštanu masu kod bolesnika sa alkoholnom cirozom jetre." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=89494&source=NDLTD&language=en.

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Uvod: Hepatička osteodistrofija je termin koji obuhvata metaboličke bolesti kosti udružene sa hroničnim bolestima jetre. U alkoholnoj cirozi (AC) jetre postoji visoka zastupljenost deficijencije vitamina D proporcionalna stepenu disfunkcije jetre, ali njena uloga u patogenezi hepatičke osteodistrofije nije dovoljno obja&scaron;njena. Nivo 25(OH)D odražava status vitamina D. Kod AC jetre izmenjena je metabolička aktivnost kosti i suprimirano je formiranje kosti &scaron;to dovodi do smanjenja ko&scaron;tane mase. U centru interesovanja je postizanje optimalnog statusa vitamina D. Stavovi o suple
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16

Delacôte, Claire. "Vers une meilleure compréhension de la maladie du foie liée à l'alcool et des facteurs influençant sa progression : approche de modélisation." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S029.

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En France, la consommation excessive d’alcool est la première cause de cirrhose et de carcinome hépatocellulaire (CHC), devant les hépatites virales et le syndrome métabolique. En 2016, on recense près de 10 500 décès par cirrhose ou CHC, et ce malgré une diminution significative de la consommation per capita d’alcool depuis 1960 (26L en 1960, 11,7L en 2017).Les personnes consommant de l’alcool ont un risque de développer une maladie du foie liée à l’alcool (MFLA). Elle évolue du stade initial de stéatose vers des stades plus avancés de fibrose et de cirrhose, pouvant se compliquer d’une décom
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17

Čihák, Jakub. "Alkonomie." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-163942.

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This diploma thesis investigates the relationship between the business cycle and the alcohol consumption by using aggregate data for Czech Republic and constituent regions of Czech Republic in the period 1994-2011. The key question of this study is whether alcohol consumption is pro-cyclical or counter-cyclical. This question was asked in many works (Ruhm, Black, 2002). Unlike American studies, in which alcohol consumption is pro-cyclical, my study shows that the decrease of economic conditions has resulted in increased alcohol consumption in society and therefore indicates to me counter-cycli
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18

James, Brandon C. "Understanding the role of miRNAs in neuroinflammation." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415826.

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Chronic alcohol abuse is a key component of alcohol use disorder and leads to adverse changes in localised regions of the human brain (Zahr & Pfefferbaum, 2017). The prefrontal cortex is particularly susceptible to damage following chronic alcohol abuse (Abernathy et al., 2010). Differential gene expression in the prefrontal cortex has been identified between alcoholics and controls, and includes genes related to immune/stress response (Liu et al., 2006). A chronic immune response in the central nervous system, termed neuroinflammation, has been implicated in the progression of alcohol-induced
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19

Rehm, Jürgen, Peter Anderson, Joe Barry, et al. "Prevalence of and Potential Influencing Factors for Alcohol Dependence in Europe." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A71615.

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Alcohol use disorders (AUDs), and alcohol dependence (AD) in particular, are prevalent and associated with a large burden of disability and mortality. The aim of this study was to estimate prevalence of AD in the European Union (EU), Iceland, Norway, and Switzerland for the year 2010, and to investigate potential influencing factors. The 1-year prevalence of AD in the EU was estimated at 3.4% among people 18–64 years of age in Europe (women 1.7%, men 5.2%), resulting in close to 11 million affected people. Taking into account all people of all ages, AD, abuse and harmful use resulted in an est
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20

Djalali, Mahmoud. "Contribution à l'étude du métabolisme digestif des corrinoïdes chez l'homme dans les conditions physiologiques et pathologiques." Nancy 1, 1988. http://www.theses.fr/1988NAN10030.

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Mise au point de la purification des corrinoïdes et leur séparation par chromatographie liquide à haute performance. La détermination quantitative a été réalisée par dosage radioisotopique des corrinoïdes présents dans les fractions issues de la chromatographie. Les analogues représentent respectivement 18,5 %, 55 % et 95 % des corrinoïdes présents dans le plasma, la bile et les selles. L'étude de l'étape porto-hépatique du cycle entérohépatique des corrinoïdes a permis de mettre en évidence l'origine principalement digestive des analogues de la vitamine B12. Après avoir montré l'importance de
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21

Hsiao, Jong-Kai, and 蕭仲凱. "Clinical manifestation of H1 magnetic resonance spectroscopy in non-alcoholic liver cirrhosis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/32625008314480518919.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>93<br>Magnetic Resonance Spectroscopy (MRS) is commonly applied in medicine with 1H proton or 31phosphorus spectra. The proton MRS is often used in evaluating the central nervous system such as metabolites in epilepsy, diagnosis of brain tumor and biological change after acute ischemic stroke(Hammen et al. 2003). 31P MRS was used in muscular disease or neoplasm(Munakata et al. 1993). F19 was often used for monitoring of drug delivery to the body(Klomp et al. 2003). Because of the richness in proton in the human body, it is advantageous to get higher signal/noise rat
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Liao, Fang-mien, and 廖芳綿. "A Narrative Research on the Life Experience of an Alcoholic Liver Cirrhosis Patient." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/57678837165338080673.

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碩士<br>南華大學<br>生死學研究所<br>96<br>The purpose of this study was to explore the life experience of a alcoholic liver cirrhosis patient how to shape the unique individuality. The author took narrative as research method to press close to subjective experience and life world of the research-participator, common to comprise the life story of context coherent. Life experiences that can affect the research-participator’s self-identity, including: the family, working, affections, violence, illness experiences, and that the significant others: parents, peer groups, wife and daughters to have direct relati
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Holcová, Zuzana. "Dietní opatření při onemocnění jater." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-387332.

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Master thesis summarizes latest knowledge in the field of special nutrition for patients with liver condition. Theoretical chapters describe liver physiology and etiology of selected liver diseases e.g. hepatitis, cirrhosis, chemical-driven liver damage. Given the fact the main cause of chronic liver disease is globally considered alcohol, a special chapter is dedicated to this topic which describes pathogenesis of alcoholic liver disease, the effect of chronic alcohol consumption on hepatocytes and other non-parenchymal liver cells. The thesis provides a comprehensive view on the issue of mal
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