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Journal articles on the topic 'Alkamide'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rogers, K. L., I. D. Grice, C. J. Mitchell, and L. R. Griffiths. "High performance liquid chromatography determined alkamide levels in Australian-grown Echinacea spp." Australian Journal of Experimental Agriculture 38, no. 4 (1998): 403. http://dx.doi.org/10.1071/ea98001.

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Summary. Extracts of Echinacea spp. are widely used as therapeutic immunostimulants with such activity being attributed in part to the alkamide fractions of these plants. Using high performance liquid chromatography, the levels of 8 alkamides, including 2 tetraene alkamides (dodeca-2E, 4E, 8Z, 10E/Z-tetraenoic acid isobutylamide), were quantitatively determined in 2 Australian-grown Echinacea spp. Overall, the levels of alkamides in Australian-grown E. angustifolia were found to be comparable with levels obtained in this study and other studies for USA and European Echinacea spp. However, resu

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2

Vázquez-Martínez, Juan, and Jorge Molina-Torres. "Alkamide Content and Localization in Heliopsis longipes Cypselae, Obtained via Fluorescence and Double-Multiphoton Microscopy." Molecules 29, no. 23 (2024): 5651. http://dx.doi.org/10.3390/molecules29235651.

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The alkamide content and specific tissue localization in the cypselae of Heliopsis longipes were investigated using gas chromatography–electron ionization mass spectrometry (GC-EIMS) and multiphoton fluorescence microscopy (MPFM). GC-EIMS analysis identified two olefinic alkamides: affinin (spilanthol) and N-2-methylbutyl-2E,6Z,8E-decatrienamide. Microscopic analysis revealed that alkamides are localized within the cotyledons, and specifically compartmentalized in lipid bodies, highlighting their spatial organization. The linear unmixing of fluorescence emission fingerprints showed that affini

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3

Lu, I.-Cheng, Pin-Yang Hu, Chia-Heng Lin, et al. "Alkamides in Zanthoxylum Species: Phytochemical Profiles and Local Anesthetic Activities." International Journal of Molecular Sciences 25, no. 22 (2024): 12228. http://dx.doi.org/10.3390/ijms252212228.

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Zanthoxylum species have long been utilized in traditional medicine; among their various properties, they provide an analgesic effect. Central to this medicinal application are alkamides, a class of alkaloids characterized by their unsaturated fatty acid chains. These compounds are particularly noted for their distinctive alleviation of tingling and numbing effects, which are beneficial in dental pain management and local anesthesia. This review synthesizes the existing phytochemical research on alkamides derived from 11 Z. species, focusing on their chemical properties, pharmacodynamics and c

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4

Campos-García, Tonatiu, and Jorge Molina-Torres. "Solanum lycopersicum Seedlings. Metabolic Responses Induced by the Alkamide Affinin." Metabolites 11, no. 3 (2021): 143. http://dx.doi.org/10.3390/metabo11030143.

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Alkamides have been observed to interact in different ways in several superior organisms and have been used in traditional medicine in many countries e.g., to relieve pain. Previous studies showed that affinin when applied to other plant species induces prominent changes in the root architecture and induces transcriptional adjustments; however, little is known about the metabolic pathways recruited by plants in response to alkamides. Previous published work with Arabidopsis seedlings treated in vitro with affinin at 50 µM significantly reduced primary root length. In tomato seedlings, that con

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5

Qu, Luping, Ying Chen, Xiping Wang, Richard Scalzo, and Jeanine M. Davis. "Patterns of Variation in Alkamides and Cichoric Acid in Roots and Aboveground Parts of Echinacea purpurea (L.) Moench." HortScience 40, no. 5 (2005): 1239–42. http://dx.doi.org/10.21273/hortsci.40.5.1239.

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We investigated patterns of variation in alkamides and cichoric acid accumulation in the roots and aboveground parts of Echinacea purpurea (L.) Moench. These phytochemicals were extracted from fresh plant parts with 60% ethanol and quantified by high performance liquid chromatography (HPLC) analysis. Concentrations of alkamides and cichoric acid were measured on a dry-weight basis (mg·g–1). For total alkamides, concentrations among individual plants varied from 5.02 to 27.67 (mean = 14.4%) in roots, from 0.62 to 3.42 (mean = 1.54) in nearly matured seed heads (NMSH), and 0.22 to 5.25 (mean = 0

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6

Buitimea-Cantúa, Génesis V., Nayelli Marsch-Martinez, Patricia Ríos-Chavez, Alfonso Méndez-Bravo, and Jorge Molina-Torres. "Global gene expression analyses of the alkamide-producing plant Heliopsis longipes supports a polyketide synthase-mediated biosynthesis pathway." PeerJ 8 (September 25, 2020): e10074. http://dx.doi.org/10.7717/peerj.10074.

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Background Alkamides are plant-specific bioactive molecules. They are low molecular weight N-substituted α-unsaturated acyl amides that display biological explicit activities in different organisms from bacteria, fungi, insects to mammals and plants. The acyl chain has been proposed to be biosynthesized from a fatty acid; however, this has not been demonstrated yet. Heliopsis longipes (Asteraceae) accumulates in root a C10 alkamide called affinin in its roots, but not in leaves. The closely related species Heliopsis annua does not produce alkamides. To elucidate the biosynthetic pathway of the

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7

Reyes-Trejo, Benito, Mario Noel Morales-Hernández, Gloria Melisa González-Anduaga, José Luis Balderas-López, José Carlos Tavares-Carvalho та Andrés Navarrete. "Evidence for Involvement of TRPV1 Receptors and Potassium Channels in the Seizures Induced by α-Sanshool". Planta Medica International Open 6, № 01 (2019): e23-e27. http://dx.doi.org/10.1055/a-0871-2496.

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Abstract α-Sanshool is an alkamide isolated from the stem bark of Zanthoxylum liebmannianum, a Mexican medicinal plant known as Colopahtle. Our research group has reported that the intraperitoneal administration of α-sanshool induces tonic-clonic seizures in mice. In the present study, we investigated the convulsive effect of this alkamide and elucidated its mechanism of action by comparing with well-known convulsive and anticonvulsive drugs in an in vivo approach. α-Sanshool showed a potent (ED50 [CL 95%]=3.06 [2.92–3.22] mg/kg) and immediate (2±2 s) seizure effect after the intraperitoneal a

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8

Matiadis, Dimitris, Eleni Kakouri, Eleftheria H. Kaparakou, and Petros A. Tarantilis. "Guineensine: Isolation, Synthesis, and Biological Activity." Applied Sciences 15, no. 3 (2025): 1444. https://doi.org/10.3390/app15031444.

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The genus Piper is the largest among plants of the Piperaceae family. Phytochemical studies on various piper species indicate the presence of bioactive compounds, with alkamides being among the most prominent. Piperine is well studied, and is usually found in abundance in most species. Guineensine is an alkamide that merits particular interest and, until now, has received less scientific attention. Therefore, in the present review, we discuss guineensine’s isolation, synthesis, and pharmacological activity. Data were collected from 1974 to 2024. Databases including PubMed, Google Scholar, and

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9

Powell, Erin E., Danielle Julie Carrier, Trever G. Crowe, and Myles R. L. Bantle. "Echinacoside and Alkamide Distribution inEchinacea angustifoliaRoot." Journal of Nutraceuticals, Functional & Medical Foods 3, no. 3 (2001): 95–107. http://dx.doi.org/10.1300/j133v03n03_05.

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10

Srinivas, P. V., and J. Madhusudana Rao. "Isopiperolein B: an alkamide from Piper nigrum." Phytochemistry 52, no. 5 (1999): 957–58. http://dx.doi.org/10.1016/s0031-9422(99)00287-3.

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11

Lin, Kai-Wei, Dravidum Maitraie, A.-Mei Huang, Jih-Pyang Wang, and Chun-Nan Lin. "Triterpenoids and an alkamide from Ganoderma tsugae." Fitoterapia 108 (January 2016): 73–80. http://dx.doi.org/10.1016/j.fitote.2015.11.003.

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12

Romero, Fredy R., Kathleen Delate, George A. Kraus, Avery K. Solco, Patricia A. Murphy, and David J. Hannapel. "Alkamide production from hairy root cultures of Echinacea." In Vitro Cellular & Developmental Biology - Plant 45, no. 5 (2009): 599–609. http://dx.doi.org/10.1007/s11627-008-9187-1.

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13

Ingólfsdóttir, K., S. R. Gissurarson, A. Nenninger, A. Neszmelyi, B. Wiedemann, and H. Wagner. "Biologically active alkamide from the lichen Stereocaulon alpinum." Phytomedicine 4, no. 4 (1997): 331–34. http://dx.doi.org/10.1016/s0944-7113(97)80042-6.

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14

Sarmento Silva, T. M., R. Braz-Filho, M. G. de Carvalho, and M. F. Agra. "Flavonoids and an alkamide from Solanum paludosum Moric." Biochemical Systematics and Ecology 30, no. 5 (2002): 479–81. http://dx.doi.org/10.1016/s0305-1978(01)00105-3.

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15

Hamimed, Souad, Nadji Boulebda, Hocine Laouer, and Abdelmalik Belkhiri. "Bioactivity-guided isolation of alkamides from a cytotoxic fraction of the ethyl acetate extract of Anacyclus pyrethrum (L.) DC. roots." Current Issues in Pharmacy and Medical Sciences 31, no. 4 (2018): 180–85. http://dx.doi.org/10.1515/cipms-2018-0033.

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Abstract Introduction. The alcohol extract of Pellitory (Anacyclus pyrethrum) roots has been previously shown to exert anticancer activities on the Human Colorectal Cancer Cell Line (HCT) by targeting apoptosis, metastasis and cell cycle arrest. However, the nature of the cytotoxic molecules associated with this activity remains unexplored. Aims. This study aims to reinvestigate Pellitory root extract as regard to its cytotoxic activity and to proceed to a bioguided fractionation to explore its active fraction and to give new insight in their phytochemical constituents. Methods. Powdered roots

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16

S., S. BARI, P. VIG O., A. SATTAR M., K. SETHI MADHURESH, and K. SHARMA A. "A Stereoselective Synthesis of N-[7-(3' ,4'-Methylenedioxyphenyl)-2E,6E-heptadienoyl] pyrrolidine (Sarmentosine). A New Alkamide isolated from Pipersarmentosum." Journal of Indian Chemical Society Vol. 73, Oct 1996 (1996): 520–22. https://doi.org/10.5281/zenodo.5902503.

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Department of Chemistry, Panjab University. Chandigarh-160 014 <em>Manuscript received 26 September 1991, revised  27 January 1995, accepted 11 February 1995</em> A convenient stercoselective synthesis of <em>N</em>-[7-(3', 4'-methylenedioxyphenyl)-2<em>E</em>, 6<em>E</em>- hepladienoyl]pyrrolidine (l), an alkaloid isolated from the genus piper, has been performed starting from piperonal, where the stereochemistry was fixed by utilising the modified Wittig reaction.

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17

Liu, W. X., M. Dong, R. Q. Zhang, et al. "New Benzylated Alkamide from the Roots of Lepidium meyenii." Chemistry of Natural Compounds 55, no. 4 (2019): 696–99. http://dx.doi.org/10.1007/s10600-019-02781-w.

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18

Srinivas, P. V., and J. Madhusudana Rao. "ChemInform Abstract: Isopiperolein B: An Alkamide from Piper nigrum." ChemInform 31, no. 10 (2010): no. http://dx.doi.org/10.1002/chin.200010227.

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19

Matthias, A., R. S. Addison, K. G. Penman, R. G. Dickinson, K. M. Bone, and R. P. Lehmann. "Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion." Life Sciences 77, no. 16 (2005): 2018–29. http://dx.doi.org/10.1016/j.lfs.2005.04.009.

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20

Rios, María Yolanda, A. Berenice Aguilar-Guadarrama, and María del Carmen Gutiérrez. "Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae)." Journal of Ethnopharmacology 110, no. 2 (2007): 364–67. http://dx.doi.org/10.1016/j.jep.2006.09.041.

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21

Althaus, Julia, Marcel Kaiser, Reto Brun, and Thomas Schmidt. "Antiprotozoal Activity of Achillea ptarmica (Asteraceae) and Its Main Alkamide Constituents." Molecules 19, no. 5 (2014): 6428–38. http://dx.doi.org/10.3390/molecules19056428.

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22

Rios-Chavez, P., E. Ramirez-Chavez, C. Armenta-Salinas, and J. Molina-Torres. "Acmella radicans var. radicans: In vitro culture establishment and alkamide content." In Vitro Cellular & Developmental Biology - Plant 39, no. 1 (2003): 37–41. http://dx.doi.org/10.1079/ivp2002354.

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23

Perry, Nigel B., John W. van Klink, Elaine J. Burgess, and Graeme A. Parmenter. "Alkamide Levels in Echinacea purpurea: Effects of Processing, Drying and Storage." Planta Medica 66, no. 1 (2000): 54–56. http://dx.doi.org/10.1055/s-2000-11111.

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24

Ndom, Jean C., Joseph T. Mbafor, Luc M. Meva’a, et al. "New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)." Phytochemistry Letters 3, no. 4 (2010): 201–6. http://dx.doi.org/10.1016/j.phytol.2010.07.007.

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25

Duarte, Allana Brunna S., Rebeca C. Gomes, Vitória Regina V. Nunes, et al. "The Antitumor Activity of Piplartine: A Review." Pharmaceuticals 16, no. 9 (2023): 1246. http://dx.doi.org/10.3390/ph16091246.

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Cancer is a worldwide health problem with high mortality in children and adults, making searching for novel bioactive compounds with potential use in cancer treatment essential. Piplartine, also known as piperlongumine, is an alkamide isolated from Piper longum Linn, with relevant therapeutic potential. Therefore, this review covered research on the antitumor activity of piplartine, and the studies reported herein confirm the antitumor properties of piplartine and highlight its possible application as an anticancer agent against various types of tumors. The evidence found serves as a reference

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26

Méndez-Bravo, Alfonso, Javier Raya-González, Luis Herrera-Estrella, and José López-Bucio. "Nitric Oxide is Involved in Alkamide-Induced Lateral Root Development in Arabidopsis." Plant and Cell Physiology 51, no. 10 (2010): 1612–26. http://dx.doi.org/10.1093/pcp/pcq117.

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27

Artaria, C., G. Maramaldi, A. Bonfigli, L. Rigano, and G. Appendino. "Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum." International Journal of Cosmetic Science 33, no. 4 (2011): 328–33. http://dx.doi.org/10.1111/j.1468-2494.2010.00629.x.

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28

Ley, Jakob�P, Jens-Michael Hilmer, Berthold Weber, Gerhard Krammer, Ian�L Gatfield, and Heinz-J�rgen Bertram. "Stereoselective Enzymatic Synthesis ofcis-Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon." European Journal of Organic Chemistry 2004, no. 24 (2004): 5135–40. http://dx.doi.org/10.1002/ejoc.200400403.

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29

Ley, Jakob�P, Jens-Michael Hilmer, Berthold Weber, Gerhard Krammer, Ian�L Gatfield, and Heinz-J�rgen Bertram. "Stereoselective Enzymatic Synthesis ofcis-Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon." European Journal of Organic Chemistry 2005, no. 3 (2005): 618. http://dx.doi.org/10.1002/ejoc.200400893.

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30

Ye, Yan-Qing, Zu-Hong Ma, Qiao-Fen Yang, et al. "Isolation and synthesis of a new benzylated alkamide from the roots of Lepidium meyenii." Natural Product Research 33, no. 19 (2018): 2731–37. http://dx.doi.org/10.1080/14786419.2018.1499633.

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31

López-Bucio, José, Mayra Millán-Godínez, Alfonso Méndez-Bravo, et al. "Cytokinin Receptors Are Involved in Alkamide Regulation of Root and Shoot Development in Arabidopsis." Plant Physiology 145, no. 4 (2007): 1703–13. http://dx.doi.org/10.1104/pp.107.107953.

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32

Liu, Yi, and Patricia A. Murphy. "Alkamide Stability inEchinacea purpureaExtracts with and without Phenolic Acids in Dry Films and in Solution." Journal of Agricultural and Food Chemistry 55, no. 1 (2007): 120–26. http://dx.doi.org/10.1021/jf0619481.

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33

ARAÚJO, Éverton José Ferreira de, Layana Karine Farias LIMA, Oskar Almeida SILVA, et al. "In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)." Acta Amazonica 46, no. 3 (2016): 309–14. http://dx.doi.org/10.1590/1809-4392201505436.

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ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes

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34

Park, InWha, Hee Sun Byun, Gang Min Hur та MinKyun Na. "Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation". Journal of Natural Products 84, № 5 (2021): 1598–606. http://dx.doi.org/10.1021/acs.jnatprod.1c00146.

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35

Silveira, Narjara, Julia Saar, Alan Santos, et al. "A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity." Molecules 21, no. 6 (2016): 765. http://dx.doi.org/10.3390/molecules21060765.

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36

Perry, Nigel, John van Klink, Elaine Burgess, and Graeme Parmenter. "Alkamide Levels inEchinacea purpurea: A Rapid Analytical Method Revealing Differences among Roots, Rhizomes, Stems, Leaves and Flowers." Planta Medica 63, no. 01 (1997): 58–62. http://dx.doi.org/10.1055/s-2006-957605.

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37

Gray, Dean, Stephen Pallardy, H. Garrett, and George Rottinghaus. "Acute Drought Stress and Plant Age Effects on Alkamide and Phenolic Acid Content in Purple Coneflower Roots." Planta Medica 69, no. 01 (2003): 50–55. http://dx.doi.org/10.1055/s-2003-37026.

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38

Bezerra, Daniel Pereira, Dinara Jaqueline Moura, Renato Moreira Rosa, et al. "Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 652, no. 2 (2008): 164–74. http://dx.doi.org/10.1016/j.mrgentox.2008.02.001.

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39

Fontenele, Juvenia B., L. Kalyne A. M. Leal, Edilberto R. Silveira, F. Helder Felix, Cícero F. Bezerra Felipe, and Glauce S. B. Viana. "Antiplatelet effects of piplartine, an alkamide isolated fromPiper tuberculatum: possible involvement of cyclooxygenase blockade and antioxidant activity." Journal of Pharmacy and Pharmacology 61, no. 4 (2009): 511–15. http://dx.doi.org/10.1211/jpp.61.04.0014.

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40

Arifin, Poppy Firzani, Theoprawira Imanuel Yobert ASSA, Adri Nora, and Rosalina Wisastra. "EVALUATING THE ANTIOXIDANT ACTIVITY OF Echinacea purpurea (L.) Moench ETHANOL EXTRACT." Indonesian Journal of Biotechnology and Biodiversity 6, no. 2 (2022): 39–44. http://dx.doi.org/10.47007/ijobb.v6i2.132.

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The purpose of this research was to extract the yield of Echinacea purpurea at the SOHO Center of Excellence in Herbal Research Sukabumi on a laboratory scale and determine the antioxidant effect. This plant is known to grow in Europe before being cultivated in Sukabumi, Indonesia. Additionally, the specimen contains compounds with antioxidant functionalities, estimated to be useful in cell protection from oxidative stress. This property is attributed to the presence of alkamide compounds. In this research, Simplicia was extracted using 2 different methods, and those generated by DPPH yielded

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41

Silva, Rayanne H. N., Emanuel P. Magalhães, Rebeca C. Gomes, Yunierkis Perez-Castillo, Alice M. C. Martins, and Damião P. de Sousa. "Piplartine Synthetic Analogs: In Silico Analysis and Antiparasitic Study against Trypanosoma cruzi." Applied Sciences 13, no. 20 (2023): 11585. http://dx.doi.org/10.3390/app132011585.

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Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi. Piplartine is an alkamide present in various species of the genus Piper that possess trypanocidal activity. In this study, the antiparasitic potential of a collection of 23 synthetic analogs of piplartine against Trypanosoma cruzi was evaluated in vitro. The compounds were prepared via amidation and esterification reactions using 3,4,5-trimethoxybenzoic acid as starting material. The products were structurally characterized using 1H a

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42

Rizhsky, Ludmila, Huanan Jin, Michael R. Shepard, et al. "Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis." Plant Journal 88, no. 5 (2016): 775–93. http://dx.doi.org/10.1111/tpj.13295.

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43

Velez-Haro, John M., Nydia E. Buitimea-Cantúa, Ema C. Rosas-Burgos, Jorge Molina-Torres, and Génesis V. Buitimea-Cantúa. "EFFECT OF THE ROOTS EXTRACT FROM Heliopsis longipes ON Aspergillus parasiticus GROWTH." Biotecnia 20, no. 3 (2018): 127–34. http://dx.doi.org/10.18633/biotecnia.v20i3.720.

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The organic extracts from Heliopsis longipes roots possess interesting biological and pharmacological activities. However, the effect on Aspergillus parasiticus has not been investigated so far. This study was aimed to evaluate the antifungal effect of the ethanolic extract from H. longipes roots against A. parasiticus growth. Four extract concentrations, 50, 75, 150 and 200 μg/mL were evaluated for antifungal effect, and the anti-aflatoxigenic assay was tested at 150 and 200 μg/mL. The minimal inhibitory concentration that inhibited 50 and 99% of growth (MIC50 and MIC99) were determined. Etha

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44

Bakondi, Edina, Salam Bhopen Singh, Zoltán Hajnády, et al. "Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis." International Journal of Molecular Sciences 20, no. 17 (2019): 4308. http://dx.doi.org/10.3390/ijms20174308.

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Activated macrophages upregulate inducible nitric oxide synthase (iNOS) leading to the profuse production of nitric oxide (NO) and, eventually, tissue damage. Using macrophage NO production as a biochemical marker of inflammation, we tested different parts (flower, leaf, and stem) of the medicinal plant, Spilanthes acmella. We found that extracts prepared from all three parts, especially the flowers, suppressed NO production in RAW macrophages in response to interferon-γ and lipopolysaccharide. Follow up experiments with selected bioactive molecules from the plant (α-amyrin, β-caryophylline, s

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45

Silva, Rayanne H. N., Thaíssa Q. Machado, Anna Carolina C. da Fonseca, et al. "Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma." Molecules 28, no. 4 (2023): 1675. http://dx.doi.org/10.3390/molecules28041675.

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Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approximately 90% located mainly on the tongue and floor of the mouth. Piplartine is an alkamide found in certain species of the genus Piper and presents many pharmacological properties including antitumor activity. In the present study, the cytotoxic potential of a collection of piplartine analogs against

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46

Singh, Meenakshi, A. V. Amrutha Krishnan, Ramkrishna Mandal, et al. "Azomethine ylide cycloaddition: a versatile tool for preparing novel pyrrolizidino-spiro-oxindolo hybrids of the doubly conjugated alkamide piperine." Molecular Diversity 24, no. 3 (2019): 627–39. http://dx.doi.org/10.1007/s11030-019-09969-w.

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47

Fontenele, Juvenia B., L. Kalyne A. M. Leal, Edilberto R. Silveira, F. Helder Felix, Cícero F. Bezerra Felipe, and Glauce S. B. Viana. "Antiplatelet effects of piplartine, an alkamide isolated from Piper tuberculatum: possible involvement of cyclooxygenase blockade and antioxidant activity." Journal of Pharmacy and Pharmacology 61, no. 4 (2009): 511–15. http://dx.doi.org/10.1211/jpp/61.04.0014.

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Nóbrega, Flávio R., Larisse V. Silva, Carlos da Silva M. Bezerra Filho, et al. "Design, Antileishmanial Activity, and QSAR Studies of a Series of Piplartine Analogues." Journal of Chemistry 2019 (January 8, 2019): 1–12. http://dx.doi.org/10.1155/2019/4785756.

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Abstract:

Piplartine is an alkamide found in different Piper species and possesses several biological activities, including antiparasitic properties. Thus, the aim of the present study was to evaluate a series of 32 synthetic piplartine analogues against the Leishmania amazonensis promastigote forms and establish the structure-activity relationship and 3D-QSAR of these compounds. The antileishmanial effect of the compounds was determined using the MTT method. Most compounds were found to be active against L. amazonensis. Among 32 assayed derivatives, compound (E)-(−)-bornyl 3-(3,4,5-trimethoxyphenyl)-ac

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Sancha, Shirley A. R., Adriana V. Gomes, Joana B. Loureiro, Lucília Saraiva, and Maria-José U. Ferreira. "Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells." Molecules 27, no. 18 (2022): 5759. http://dx.doi.org/10.3390/molecules27185759.

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Abstract:

Aiming to find Amaryllidaceae alkaloids against breast cancer, including the highly aggressive triple-negative breast cancer, the phytochemical study of Pancratium maritimum was carried out. Several Amaryllidaceae-type alkaloids, bearing scaffolds of the haemanthamine-, homolycorine-, lycorine-, galanthamine-, and tazettine-type were isolated (3–11), along with one alkamide (2) and a phenolic compound (1). The antiproliferative effect of compounds (1–11) was evaluated by the sulforhodamine B assay against triple-negative breast cancer cell lines MDA-MB-231 and MDA-MB-468, breast cancer cells M

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Hasa, Dritan, Simon Žakelj, Iztok Grabnar, et al. "Echinacea angustifolia DC. Lipophilic Extract Patch for Skin Application: Preparation, In Vitro and In Vivo Studies." Pharmaceutics 12, no. 11 (2020): 1096. http://dx.doi.org/10.3390/pharmaceutics12111096.

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Abstract:

Dodeca-2E,4E,8Z,10E/Z-tetraenoic isobutylamide (tetraene) is the main component of Echinacea angustifolia DC. lipophilic extract, the bioavailability and immunomodulatory effect after oral administration in soft gel capsules in healthy volunteers of which we have already demonstrated. In the present work, we assessed the transdermal administration as an alternative route of administration of such an alkamide. The first step, therefore, encompassed the preparation of a drug-in-adhesive patch with an area of 868 mm2 and containing a dose of 0.64 mg of tetraene. In vitro skin permeation studies i

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