Academic literature on the topic 'Amide proton transfer'

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Journal articles on the topic "Amide proton transfer"

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V. Komarov, Igor, Aleksandr Yu. Ishchenko, Aleksandr Hovtvianitsa, et al. "Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group—A Model for yet Unknown Peptidases?" Molecules 24, no. 3 (2019): 572. http://dx.doi.org/10.3390/molecules24030572.

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Unconstrained amides that undergo fast hydrolysis under mild conditions are valuable sources of information about how amide bonds may be activated in enzymatic transformations. We report a compound possessing an unconstrained amide bond surrounded by an amino and a carboxyl group, each mounted in close proximity on a bicyclic scaffold. Fast amide hydrolysis of this model compound was found to depend on the presence of both the amino and carboxyl functions, and to involve a proton transfer in the rate-limiting step. Possible mechanisms for the hydrolytic cleavage and their relevance to peptide
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Wójcik, J., K. Ruszczyńska, I. Zhukov, and A. Ejchart. "NMR measurements of proton exchange between solvent and peptides and proteins." Acta Biochimica Polonica 46, no. 3 (1999): 651–63. http://dx.doi.org/10.18388/abp.1999_4137.

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Scope and limitations of the NMR based methods, equilibration and magnetization transfer, for measuring proton exchange rates of amide protons in peptides and proteins with water protons are discussed. Equilibration is applied to very slow processes detected by hydrogen-deuterium exchange after a solute is dissolved in D2O. Magnetization transfer allows to study moderately rapid processes in H2O. A number of precautions should be undertaken in order to avoid systemic errors inherent in the magnetization transfer method.
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Song, Qingxu, Chencheng Zhang, Xin Chen, and Yufeng Cheng. "Comparing amide proton transfer imaging with dynamic susceptibility contrast-enhanced perfusion in predicting histological grades of gliomas: a meta-analysis." Acta Radiologica 61, no. 4 (2019): 549–57. http://dx.doi.org/10.1177/0284185119871667.

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Background As a subtype of chemical exchange saturation transfer imaging without contrast agent administration, amide proton transfer (APT) imaging has demonstrated the potential for differentiating the histologic grades of gliomas. Dynamic susceptibility contrast-enhanced perfusion, a perfusion-weighted imaging technique, is a well-established technique in grading gliomas. Purpose To compare the ability of amide proton transfer and dynamic susceptibility contrast-enhanced imaging for predicting the grades of gliomas. Material and Methods A comprehensive literature search was performed indepen
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Dai, Z., G. Yan, S. Li, et al. "Optimized amide proton transfer imaging of ischemic stroke." Journal of the Neurological Sciences 333 (October 2013): e234. http://dx.doi.org/10.1016/j.jns.2013.07.914.

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Tang, Guo Qing, Jean MacInnis, and Michael Kasha. "Proton-transfer spectroscopy of benzanilide. Amide-imidol tautomerism." Journal of the American Chemical Society 109, no. 8 (1987): 2531–33. http://dx.doi.org/10.1021/ja00242a058.

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Law, Benjamin King Hong, Ann D. King, Qi-Yong Ai, et al. "Head and Neck Tumors: Amide Proton Transfer MRI." Radiology 288, no. 3 (2018): 782–90. http://dx.doi.org/10.1148/radiol.2018171528.

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Ji, Chong-Lei, Pei-Pei Xie, and Xin Hong. "Computational Study of Mechanism and Thermodynamics of Ni/IPr-Catalyzed Amidation of Esters." Molecules 23, no. 10 (2018): 2681. http://dx.doi.org/10.3390/molecules23102681.

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Nickel catalysis has shown remarkable potential in amide C–N bond activation and functionalization. Particularly for the transformation between ester and amide, nickel catalysis has realized both the forward (ester to amide) and reverse (amide to ester) reactions, allowing a powerful approach for the ester and amide synthesis. Based on density functional theory (DFT) calculations, we explored the mechanism and thermodynamics of Ni/IPr-catalyzed amidation with both aromatic and aliphatic esters. The reaction follows the general cross-coupling mechanism, involving sequential oxidative addition,
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Zheng, Yang, Xiaoming Wang, and Xuna Zhao. "Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development." BioMed Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3052723.

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Purpose.This study aims to evaluate the process of brain development in neonates using combined amide proton transfer (APT) imaging and conventional magnetization transfer (MT) imaging.Materials and Methods.Case data were reviewed for all patients hospitalized in our institution’s neonatal ward. Patients underwent APT and MT imaging (a single protocol) immediately following the routine MR examination. Single-slice APT/MT axial imaging was performed at the level of the basal ganglia. APT and MT ratio (MTR) measurements were performed in multiple brain regions of interest (ROIs). Data was statis
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Sun, Phillip Zhe, Jinyuan Zhou, Weiyun Sun, Judy Huang, and Peter C. M. van Zijl. "Suppression of lipid artifacts in amide proton transfer imaging." Magnetic Resonance in Medicine 54, no. 1 (2005): 222–25. http://dx.doi.org/10.1002/mrm.20530.

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Zong, Xiaopeng, Ping Wang, Seong-Gi Kim, and Tao Jin. "Sensitivity and Source of Amine-Proton Exchange and Amide-Proton Transfer Magnetic Resonance Imaging in Cerebral Ischemia." Magnetic Resonance in Medicine 71, no. 1 (2013): 118–32. http://dx.doi.org/10.1002/mrm.24639.

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Dissertations / Theses on the topic "Amide proton transfer"

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Sakata, Akihiko. "Grading glial tumors with amide proton transfer MR imaging: different analytical approaches." Kyoto University, 2016. http://hdl.handle.net/2433/215431.

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Final publication is available at http://link.springer.com/article/10.1007/s11060-014-1715-8<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19605号<br>医博第4112号<br>新制||医||1014(附属図書館)<br>32641<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 村井 俊哉, 教授 平岡 眞寛, 教授 山田 泰広<br>学位規則第4条第1項該当
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Xu, Chao [Verfasser]. "Exploring novel magnetic resonance imaging markers for ischemic stroke in the application of vessel size imaging and amide proton transfer imaging / Chao Xu." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1028494939/34.

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Yu, Xue, and 于雪. "Imaging of peritoneal metastasis : evaluation of diagnostic performance of DWI-MRI and FDG-PET/CT, correlation of the functional indices and feasibility study based on amide proton transfer MRI." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193483.

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Introduction Peritoneal metastasis is advanced disease and is usually widely disseminated at the time of discovery. It is crucial to detect peritoneal metastasis at an early stage and to allow precise patient selection for the right treatments. Both fluorodeoxyglucose positron emission tomography/computed tomography (FDGPET/CT) and magnetic resonance imaging (MRI) are used in peritoneal metastasis detection. Standardized uptake value (SUV), derived from FDGPET/ CT can evaluate glucose metabolism in cells, whilst apparent diffusion coefficient (ADC) derived from diffusion-weighted MRI (DWI) i
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Tee, Yee Kai. "Quantitative measurement of pH in stroke using chemical exchange saturation transfer magnetic resonance imaging." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e5634676-55a5-43ef-92e7-12166f3d6bf0.

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Stroke is one of the leading causes of death and adult disability worldwide. The major therapeutic intervention for acute ischemic stroke is the administration of recombinant tissue plasminogen activator (rtPA) to help to restore blood flow to the brain. This has been shown to increase the survival rate and to reduce the disability of ischemic stroke patients. However, rtPA is associated with intracranial haemorrhage and thus its administration is currently limited to only about 5% of ischemic stroke patients. More advanced imaging techniques can be used to better stratify patients for rtPA tr
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Msayib, Yunus. "Quantifying impaired metabolism following acute ischaemic stroke using chemical exchange saturation transfer magnetic resonance imaging." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:a98323ce-5998-436d-bca4-09df549cf191.

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In ischaemic stroke a disruption of cerebral blood flow leads to impaired metabolism and the formation of an ischaemic penumbra in which tissue at risk of infarction is sought for clinical intervention. In stroke trials, therapeutic intervention has largely been based on perfusion-weighted measures, but these have not been shown to be good predictors of tissue outcome. The aim of this thesis was to develop analysis techniques for magnetic resonance imaging (MRI) of chemical exchange saturation transfer (CEST) in order to quantify metabolic signals associated with tissue fate in patients with a
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Frémond, Laurent. "Synthèse et étude physico-chimique de ligands macrocycliques, macrobicycliques et macrotricycliques dérivés du 5,12-dioxocyclame." Dijon, 2002. http://www.theses.fr/2002DIJOS069.

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Wu, Jun-Yi, and 吳俊毅. "Ultrafast Photoionization Induced Proton Transfer Dynamic in Phenol-Amide Cation Complex." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/yq3yud.

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碩士<br>國立清華大學<br>化學系<br>105<br>We report studies of ultrafast proton transfer (PT) reaction of phenol-N-methylformamide(PhOH-NMF) and phenol-N,N-dimethylformamide (PhOH-DMF) cation complexes by using femtosecond pump-probe photoionization-photofragmentation spectroscopy (fs-PIPF). Neutral PhOH-NMF and PhOH-DMF complexes prepared in a free jet are photoionized by femtosecond [1+1] resonance-enhanced multiphoton ionization via S1 state, and the subsequent dynamics occurring in the cations is probed by delayed pulses that result in ion fragmentation. The observed probe-wavelength dependence of the
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Shen, Kai-Lun, and 沈凱綸. "Quantum Chemistry Calculation of Substituent Effect、Stack Effect and Hydration Effect of Double Proton Transfer on Amide and Acid Molecules." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/nqn627.

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碩士<br>國立臺灣大學<br>應用力學研究所<br>104<br>We studied the N-H...O=C and O-H...O=C type hydrogen bonds by substituting alkyl groups on amide and acid molecules. All the quantum chemistry calculations were performed at Gaussian 09 software to optimize individual keto or enol structures and search the transition state of proton transfer reaction. Meanwhile,we use the IRC(Intrinsic reaction coordinate) method to plot the reaction path in order to obtain the energy barrier. In addition, the PSI4 software was utilized through the SAPT method to decompose the intermolecular interaction into several physically
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Book chapters on the topic "Amide proton transfer"

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Zhou, Jinyuan, and Jaishri O. Blakeley. "Brain Tumors: Amide Proton Transfer Imaging." In Methods of Cancer Diagnosis, Therapy, and Prognosis. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8665-5_11.

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Zhou, Jinyuan. "Amide Proton Transfer Imaging of the Human Brain." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-992-5_10.

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Zhou, Jinyuan, Yi Zhang, Shanshan Jiang, Dong-Hoon Lee, Xuna Zhao, and Hye-Young Heo. "Chapter 15 Principles and Applications of Amide Proton Transfer Imaging." In Chemical Exchange Saturation Transfer Imaging. Pan Stanford Publishing, 2017. http://dx.doi.org/10.1201/9781315364421-16.

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Wang, Puyang, Pengfei Guo, Jianhua Lu, Jinyuan Zhou, Shanshan Jiang, and Vishal M. Patel. "Improving Amide Proton Transfer-Weighted MRI Reconstruction Using T2-Weighted Images." In Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-59713-9_1.

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Wang, Silun, Samson Jarso, Peter C. M. van Zijl, and Jinyuan Zhou. "Role of Amide Proton Transfer (APT)-MRI of Endogenous Proteins and Peptides in Brain Tumor Imaging." In Functional Brain Tumor Imaging. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-5858-7_10.

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Fillaux, F., M. H. Baron, J. Tomkinson, and G. J. Kearley. "A New View of Proton Transfer Dynamics in Amides and Peptides: Vibrational Spectroscopy with Neutrons." In Spectroscopy of Biological Molecules. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0371-8_14.

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Yoshiura, Takashi. "Chemical Exchange Saturation Transfer and Amide Proton Transfer Imaging." In Bioimaging. CRC Press, 2020. http://dx.doi.org/10.1201/9780429260971-5.

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Taber, Douglass. "New Methods for Functional Group Conversion." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0008.

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Yujiro Hayashi of Tokyo University of Science and Teruaki Mukaiyama of the Kitasato Institute developed (Chem. Lett. 2008, 37, 592) a reduction-oxidation method for converting primary, secondary (such as 1, with clean inversion) and tertiary alcohols to sulfides. Peter A. Crooks of the University of Kentucky found (Chem. Lett. 2008, 37, 528) that tetrabenzylpyrophosphate 5 was an effective agent for condensing an acid 4 with an amine 6 to give the amide 7. This protocol, that runs in near quantitative yield in an hour at room temperature, with all impurities readily removable by washing with aqueous base and aqueous acid, appears to be well-suited both for scale-up, and for solid-phase synthesis. Balchandra M. Bhanage of the University of Mumbai reported (Tetrahedron Lett. 2008, 49, 965) the reductive amination of aldehydes, including 8, and ketones to the corresponding amines, using H2 and an inexpensive Fe catalyst. André Charette of the Université de Montréal showed (J. Am. Chem. Soc. 2008, 130, 18) that the Hantzsch ester 12 , in the presence of Tf2O, reduced amides selectively to amines. Esters, epoxides, ketones, nitriles and alkynes were stable to these conditions. Matthew Tudge of Merck Rahway demonstrated (Tetrahedron Lett . 2008, 49, 1041) that Br2 in DME activated NaBH4 , allowing facile reduction of esters, including the congested diester 14, at ambient temperature. David J. Procter of the University of Manchester made (J. Am. Chem. Soc. 2008, 130, 1136) the remarkable observation that six-membered ring lactones such as 16 were reduced to the corresponding diol with SmI2 . Five-membered ring and seven-membered ring lactones were not reduced under these conditions. Bruce H. Lipshutz of the University of California, Santa Barbara devised (Organic Lett . 2008, 10, 289) a convenient and economical procedure for CuH, using Cu and an inexpensive ligand in catalytic amounts, with PMHS as the bulk reductant. The reduction of 18 presumably proceeds by electron transfer, as with dissolving metal reduction, delivering 19 with the more stable trans ring fusion. In the presence of t-BuOH as a proton source, the reduction goes on to the alcohol 20.
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Tam, James P., and Y. A. Lu. "Chemoselective and orthogonal ligation techniques." In Fmoc Solid Phase Peptide Synthesis. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637256.003.0015.

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Peptide synthesis through segment ligation of unprotected peptides (total synthesis) and peptides to proteins (semi-synthesis) in aqueous solution is appealingly simple and efficient because protection and activation steps are not required. In addition, this method offers the potential to access a diverse group of macromolecules such as circular proteins, branched peptides, and protein conjugates which are difficult to obtain through conventional approaches using protecting group strategies. Furthermore, the use of unprotected peptide segments overcomes the problem of solubility encountered in the conventional approach to the synthesis of large peptides or proteins in solution. Conceptually, ligation can be approached two ways. In the first approach, a non-amide bond is formed between two peptide segments through a pair of mutually reactive functional groups. Typical methods of non-amide ligation include oxime, hydrazone, and thiazolidine as the coupling linkages. This type of reaction is traditionally referred to as chemoselective ligation. Non-amide ligation is characteristically flexible in joining two segments that result in amino-to-amino end, carboxyl-to-amine or end-to- side chain structures. This flexibility permits synthesis of protein mimetics and branched peptide dendrimers. In the second approach, an amide bond is formed through a two-step reaction sequence involving four functional moieties, two nucleophiles and two electrophiles in the reaction centre. This reaction is usually used for end-to-end coupling between the Cα-moiety of one peptide segment and the Nα-terminus of another peptide segment resulting in a peptide-backbone product. Similar to the non-amide chemoselective ligation, the first step in orthogonal ligation is a capture reaction by a pair of mutually reactive groups. In general, two nucleophiles, a weak-base nucleophile on the side chain and an α-amino, are located at the N-terminus as an N-terminal nucleophile 5 (NTN). The two electrophiles, usually an O-glycol-aldehyde or an S-ester 4, are located at the C-terminus of the another peptide segment. The initial non-amide capture of two segments through the side chain NTN with the O- or S-ester to form a covalent intermediate 6 enables the spontaneous proximity-driven intramolecular acyl transfer to occur. This intramolecular acyl migration achieves orthogonality in amide bond formation 7 between a specific α-amine in the presence of other free α- and ɛ-amines.
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Heremans, Karel, and Koen Goossens. "Pressure-Tuning Spectroscopy of Proteins: Fourier Transform Infrared Studies in the Diamond Anvil Cell." In High Pressure Effects in Molecular Biophysics and Enzymology. Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195097221.003.0007.

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The effect of hydrostatic pressure on the secondary structure of proteins can be followed by Fourier transform infrared (FTIR) spectroscopy in the diamond anvil cell. Pressure-induced changes in the amide I’ region of the deconvolved spectrum are used to follow the features of the secondary structure up to 20 kbar. The changes in the side chains such as tyrosine also can be followed. A self-deconvolution and fitting procedure is presented that allows the determination of both pressure-induced and temperature-induced changes in the secondary structure of proteins. The method takes into account the elastic, as well as the possible conformational, effects on the spectral bands of the protein. Applications are presented on pressure-induced changes in several proteins. Attention is also given to the influence of inert cosolvents. The fundamental principles of the phase diagram of proteins are presented to clarify their importance for understanding the behavior of proteins under pressure at different temperatures. Our results show that the infrared technique explores unique aspects of the behavior of proteins under these extreme conditions. The study of the effects of pressure has received considerable attention in recent years (Balny et al., 1992; Silva &amp; Weber, 1993). In general, low pressures induce reversible changes such as the dissociation of protein-protein complexes, the binding of ligands, and conformational changes. Pressures higher than about 5 kbar induce denaturation, which in most cases is irreversible. However, reports on a few proteins indicate that such high pressures may also cause reversible changes. One such protein is horse scrum albumin (Chen &amp; Heremans, 1990). A molecular interpretation of these phenomenon is based on the fact that pressure mainly affects the volume of a system, thus damping the molecular fluctuations. Temperature effects are known to affect both the kinetic energy and the volume of the system. Early in this century, it was shown that one can cook an egg by subjecting it to high pressure (Bridgman, 1914). The appearance of the pressure-induced coagulum of egg white is quite different from the coagulum induced by temperature.
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Conference papers on the topic "Amide proton transfer"

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Zhou, Iris Y., Takahiro Igarashi, Yingkun Guo, and Phillip Z. Sun. "Quantification ofin vivopH-weighted amide proton transfer (APT) MRI in acute ischemic stroke." In SPIE Medical Imaging, edited by Barjor Gimi and Robert C. Molthen. SPIE, 2015. http://dx.doi.org/10.1117/12.2082683.

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Zhao, Jing, Yinsheng Chen, Yiying Zhao, Shasha Yang, Zhongping Chen, and Yin Wu. "Assessment of chemoradiotherapy response in glioma with magnetic resonance amide proton transfer imaging in a rodent model." In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2017. http://dx.doi.org/10.1109/embc.2017.8036881.

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Jing Yuan, Qinwei Zhang, Yi-Xiang Wang, Juan Wei, and Jinyuan Zhou. "Accuracy and uncertainty of asymmetric magnetization transfer ratio quantification for amide proton transfer (APT) imaging at 3T: A Monte Carlo study." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6610705.

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Paech, D., C. Dreher, S. Regnery, et al. "Relaxation-compensated amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients." In 100. Deutscher Röntgenkongress. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0037-1682173.

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Wu, Peng, Dachao Li, Jingxin Zhang, Bing Song, and Kexin Xu. "Research on Influencing Factors of Surface Plasmon Resonance Glucose Detection Based on D-Galactose/D-Glucose Protein Immobilizied by Amine Coupling Method." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-40281.

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Prediction of blood glucose based on measuring the glucose concentration in interstitial fluid is an effectively way to control diabetes. A surface plasmon resonance (SPR) system based on a miniature integrated SPR sensor is set up in this paper to measure the glucose concentration in interstitial fluid, and the D-galactose/D-glucose Binding Protein (GGBP) which can specifically absorb glucose is immobilized onto the SPR sensor surface by amine coupling method for higher sensitivity. The experiment result is affected by various factors, such as the grime on sensor surface, baseline, flow veloc
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Chen, Kok Hao, and Jong Hyun Choi. "DNA Oligonucleotide-Templated Nanocrystals: Synthesis and Novel Label-Free Protein Detection." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11958.

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Semiconductor and magnetic nanoparticles hold unique optical and magnetic properties, and great promise for bio-imaging and therapeutic applications. As part of their stable synthesis, the nanocrystal surfaces are usually capped by long chain organic moieties such as trioctylphosphine oxide. This capping serves two purposes: it saturates dangling bonds at the exposed crystalline lattice, and it prevents irreversible aggregation by stabilizing the colloid through entropic repulsion. These nanocrystals can be rendered water-soluble by either ligand exchange or overcoating, which hampers their wi
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Hossain, Mohammad K., Samira N. Shaily, Hadiya J. Harrigan, and Terrie Mickens. "Processing of Biodegradable Polymer Composite Using Soy Protein-Based Resin and Nanoclay." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67809.

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A completely biodegradable composite was fabricated from an herbal polymer, soy protein concentrate (SPC) resin. Soy protein was modified by adding 30 wt% of glycerol and 5 wt% of poly vinyl alcohol (PVA) to enhance its mechanical as well as thermal property. 3%, 5%, 10%, and 20% nanoclay (NC) were infused into the system. To evaluate its mechanical properties, crystallinity, thermal properties, bonding interaction, and morphological evaluation, tensile, X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Fourier transform infrared spectrosco
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