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Journal articles on the topic 'Amidoximes'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Decato, Daniel A., and Orion B. Berryman. "Structural and computational characterization of a bridging zwitterionic-amidoxime uranyl complex." Organic Chemistry Frontiers 6, no. 7 (2019): 1038–43. http://dx.doi.org/10.1039/c9qo00267g.

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2

Samsonowicz-Górski, Jan, Paweł Kowalczyk, Dominik Koszelewski, et al. "The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model Bacterial E. coli Strains." Materials 14, no. 24 (2021): 7577. http://dx.doi.org/10.3390/ma14247577.

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The biological research on newly synthesized amidoximes, Boc-protected amidoximes and Boc-derived amidines, obtained by a reduction of the parent amidoximes is reported, herein. Due to the presence of a free amino group in both amidines and amidoximes, these compounds can undergo various chemical reactions such as N-alkylation and N-acylation. One such reaction is Boc-protection, often used in organic synthesis to protect the amino and imino groups. Until now, Boc-protected amidoximes have not been tested for biological activity. Amidoxime derivatives were tested on bacterial E. coli strains.

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3

Al-Mousawi, Saleh Mohammed, Moustafa Sherief Moustafa, and Mohamed Hilmy Elnagdi. "Studies with 2-Arylhydrazononitriles: Further Investigations on the Utility of 2-Arylhydrazononitriles as Precursors to 1,2,3-Triazole Amines." Journal of Chemical Research 2007, no. 9 (2007): 515–18. http://dx.doi.org/10.3184/030823407x244869.

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3-Oxo-2-arylhydrazonobutanenitriles react with hydroxylamine hydrochloride in ethanolic sodium acetate to yield either amidoximes or isoxazolamines depending on the nature of the substituent. The amidoximes cyclise in refluxing DMF containing piperidine to form 2-aryl-1,2,3-triazol-5-amines. The isoxazolamines rearranged into 1,2,3-triazolamines on refluxing in DMF. Amidoxime 2c cyclised in acetic anhydride to give 2-arylhydrazono-1,2,4-oxadiazole 9c, which rearranged to acetylamino-1,2,3-triazole 8c. The prepared acetyl-1,2,3-triazolamines 8b,c were utilised as precursors to triazolopyridines

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4

Yang, Chuting, Shuqi Pei, Baihua Chen, Lina Ye, Haizhu Yu, and Sheng Hu. "Density functional theory investigations on the binding modes of amidoximes with uranyl ions." Dalton Transactions 45, no. 7 (2016): 3120–29. http://dx.doi.org/10.1039/c5dt04645a.

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5

Sahyoun, Tanya, Axelle Arrault, and Raphaël Schneider. "Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors." Molecules 24, no. 13 (2019): 2470. http://dx.doi.org/10.3390/molecules24132470.

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Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system. Recently; many researchers tried to develop external sources to increase the NO level in the body; for example by using amidoximes and oximes which can be oxidized in vivo and release NO. In this review; the classical methods and most recent advances for the synthesis of both amidoximes and oximes are presented first. The isomers of amidoximes and oximes and their stabilities will also be described; (Z)-amidoximes and (Z)-oximes being usually

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6

Avendaño Leon, Oscar Leonardo, Christophe Curti, Hussein El-Kashef, Youssef Kabri, Sébastien Redon, and Patrice Vanelle. "4-(5-Benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-2-nitrobenzamide." Molbank 2023, no. 4 (2023): M1750. http://dx.doi.org/10.3390/m1750.

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As part of our ongoing attempt to broaden the applications of the amidoxime moiety as a potential source of new antileishmanial agents, this study focuses on the product 4-(5-Benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-2-nitrobenzamide. This unexpected amide was obtained in an 85% yield as the major product with a conventional amidoxime synthesis protocol (Ethanol/Na2CO3) involving the reaction of hydroxylamine and a nitrile group. The formation of this amide derivative instead of the expected amidoxime can be attributed to two complementary effects: the strong electron

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7

Bolotin, Dmitrii S., Mikhail V. Il'in, Alexander S. Novikov, Nadezhda A. Bokach, Vitalii V. Suslonov, and Vadim Yu Kukushkin. "Trinuclear (aminonitrone)ZnII complexes as key intermediates in zinc(ii)-mediated generation of 1,2,4-oxadiazoles from amidoximes and nitriles." New Journal of Chemistry 41, no. 5 (2017): 1940–52. http://dx.doi.org/10.1039/c6nj03508f.

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8

Kayukova, Lyudmila, Anna Vologzhanina, Pavel Dorovatovskii та ін. "Reaction Products of β-Aminopropioamidoximes Nitrobenzenesulfochlorination: Linear and Rearranged to Spiropyrazolinium Salts with Antidiabetic Activity". Molecules 27, № 7 (2022): 2181. http://dx.doi.org/10.3390/molecules27072181.

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Nitrobenzenesulfochlorination of β-aminopropioamidoximes leads to a set of products depending on the structure of the initial interacting substances and reaction conditions. Amidoximes, functionalized at the terminal C atom with six-membered N-heterocycles (piperidine, morpholine, thiomorpholine and phenylpiperazine), as a result of the spontaneous intramolecular heterocyclization of the intermediate reaction product of an SN2 substitution of a hydrogen atom in the oxime group of the amidoxime fragment by a nitrobenzenesulfonyl group, produce spiropyrazolinium ortho- or para-nitrobenzenesulfon

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9

Möhrle, Hans, Karin Bluhme-Hensen, Birgit Middelhauve, Dietrich Mootz, and Hartmut Wunderlich. "Cyclisierung von Amidoximen mit Oxybis(diphenylboran) / Cyclization of Amidoximes with Oxybis(diphenylborane)." Zeitschrift für Naturforschung B 46, no. 9 (1991): 1219–22. http://dx.doi.org/10.1515/znb-1991-0914.

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Substituted amidoximes when reacted with oxybis(diphenylborane) do not yield ester chelates as main products but boron heterocycles. The compound obtained from p-toluamidoxime was found by crystal structure analysis to be 2-phenyl-4-(4-methylphenyl)-2,3-dihydro-1,3,5,2-oxadiazaborol (9). The conformation of the molecule is determined by angles of 29.1 and 24.4° between the planes of adjacent rings. Except N–O all bonds in the heterocyclic ring contain significant π character. Molecules are linked to chains by a weak bifurcated hydrogen bond. 9 crystallizes with the monoclinic space group P21/c

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10

Hall, James Edwin, John E. Kerrigan, Kishore Ramachandran, et al. "Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs." Antimicrobial Agents and Chemotherapy 42, no. 3 (1998): 666–74. http://dx.doi.org/10.1128/aac.42.3.666.

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ABSTRACT Aromatic dicationic compounds, such as pentamidine, have potent antimicrobial activities. Clinical use of these compounds has been restricted, however, by their toxicity and limited oral activity. A novel approach, using amidoxime derivatives as prodrugs, has recently been proposed to overcome these limitations. Although results were presented for amidoxime derivatives of only one diamidine, pentamidine, the authors in the original proposal claimed that amidoxime derivatives would work as effective prodrugs for all pharmacologically active diamidines. Nine novel amidoxime derivatives

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11

Maračić, Silvija, Petra Grbčić, Suresh Shammugam, et al. "Amidine- and Amidoxime-Substituted Heterocycles: Synthesis, Antiproliferative Evaluations and DNA Binding." Molecules 26, no. 22 (2021): 7060. http://dx.doi.org/10.3390/molecules26227060.

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The novel 1,2,3-triazolyl-appended N- and O-heterocycles containing amidine 4–11 and amidoxime 12–22 moiety were prepared and evaluated for their antiproliferative activities in vitro. Among the series of amidine-substituted heterocycles, aromatic diamidine 5 and coumarine amidine 11 had the most potent growth-inhibitory effect on cervical carcinoma (HeLa), hepatocellular carcinoma (HepG2) and colorectal adenocarcinoma (SW620), with IC50 values in the nM range. Although compound 5 was toxic to non-tumor HFF cells, compound 11 showed certain selectivity. From the amidoxime series, quinoline ami

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12

Rehse, Klaus, and Franziska Brehme. "Amidoximes and Their Prodrugs." Archiv der Pharmazie 331, no. 12 (1998): 375–79. http://dx.doi.org/10.1002/(sici)1521-4184(199812)331:12<375::aid-ardp375>3.0.co;2-f.

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13

Yavuz, Cafer Tayyar. "Amidoximes: Promising Candidates for CO2Capture." Qatar Foundation Annual Research Forum Proceedings, no. 2011 (November 2011): EVP10. http://dx.doi.org/10.5339/qfarf.2011.evp10.

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14

Ranjbar-Karimi, Reza, Asma Karbakhsh-Ravari, and Alireza Poorfreidoni. "Reactions of pentafluoropyridine with amidoximes." Journal of the Iranian Chemical Society 14, no. 11 (2017): 2397–405. http://dx.doi.org/10.1007/s13738-017-1174-1.

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15

Kaugars, Girts, and William Watt. "Reactions of amidoximes with orthoacetates." Journal of Heterocyclic Chemistry 30, no. 2 (1993): 497–500. http://dx.doi.org/10.1002/jhet.5570300237.

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16

Jiang, Chan, Mingfang Li, Leitao Xu, Yangjie Yi, Jiao Ye, and Aixi Hu. "Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization." Organic & Biomolecular Chemistry 19, no. 48 (2021): 10611–16. http://dx.doi.org/10.1039/d1ob02040d.

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17

MOURA, A. L., J. F. SILVA, J. J. R. DE FREITAS, J. C. R. FREITAS, and J. R. DE FREITAS FILHO. "EXPERIENCING A SYNTHESIS ONE-POT OF 1,2,4-OXADIAZOLE MEDIATED BY MICROWAVE OVEN: GREEN CHEMISTRY IN FOCUS." Periódico Tchê Química 16, no. 32 (2019): 820–32. http://dx.doi.org/10.52571/ptq.v16.n32.2019.838_periodico32_pgs_820_832.pdf.

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1,2,4-oxadiazoles are compounds that have attracted the attention of many researchers due to their wide range of biological activities, for example, anti-inflammatory, antimicrobial, antitumor etc. The syntheses are based mostly on the use of amidoximes and acylating agents as the initial reactants. This work aims to describe a one-pot reaction for the synthesis of 1,2,4-oxadiazols, mediated by microwave irradiation, employing home-use microwave oven, in the discipline of heterocyclic Chemistry in the postgraduate. The methodology consisted of the reaction of nitriles, hydroxylamine hydrochlor

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18

Phakhodee, Wong, Chuthamat Duangkamol, Nitaya Wiriya, and Mookda Pattarawarapan. "A convenient one-pot synthesis of N-substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones." RSC Advances 8, no. 67 (2018): 38281–88. http://dx.doi.org/10.1039/c8ra08207c.

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19

Freitas Filho, João R., Renato Luiz da Silva, Edilma Elayne da Silva, Jonh Anderson M. Santos, Jucleiton José R. de Freitas, and Juliano C. R. Freitas. "Amidoximes: Applications and Methods of Synthesis." Revista Virtual de Química 7, no. 6 (2015): 2549–96. http://dx.doi.org/10.5935/1984-6835.20150153.

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20

Tronchet, Jean M. J., Guido Zosimo-landolfo, Gérald Bernardinelli, Philippe Arrizabalaga та Michel Geoffrey. "Amidoximes α-Hydroxylées Dérivées de Sucres". Journal of Carbohydrate Chemistry 5, № 4 (1986): 631–45. http://dx.doi.org/10.1080/07328308608062981.

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21

Zulfiqar, Sonia, Ferdi Karadas, Joonho Park, et al. "Amidoximes: promising candidates for CO2 capture." Energy & Environmental Science 4, no. 11 (2011): 4528. http://dx.doi.org/10.1039/c1ee02264d.

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22

MOEHRLE, H., and J. LESSEL. "ChemInform Abstract: Intramolecular Aminoalkylation of Amidoximes." ChemInform 22, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199125182.

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23

Tabélé, Clémence, Viviane dos S. Faiões, Fabien Grimaud, et al. "Original antileishmanial hits: Variations around amidoximes." European Journal of Medicinal Chemistry 148 (March 2018): 154–64. http://dx.doi.org/10.1016/j.ejmech.2018.02.029.

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24

NICOLAIDES, D. N., and E. A. VARELLA. "ChemInform Abstract: The Chemistry of Amidoximes." ChemInform 24, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.199330329.

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25

Ahmed, Ajaz, Qazi Naveed Ahmed, and Debaraj Mukherjee. "Correction: Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose." RSC Advances 12, no. 17 (2022): 10424. http://dx.doi.org/10.1039/d2ra90030k.

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Correction for ‘Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose’ by Ajaz Ahmed et al., RSC Adv., 2021, 11, 36143–36147, DOI: 10.1039/D1RA06912H.

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26

Tsantis, Sokratis T., Maria Iliopoulou, Demetrios I. Tzimopoulos, and Spyros P. Perlepes. "Synthetic and Structural Chemistry of Uranyl-Amidoxime Complexes: Technological Implications." Chemistry 5, no. 2 (2023): 1419–53. http://dx.doi.org/10.3390/chemistry5020097.

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Resource shortage is a major problem in our world. Nuclear energy is a green energy and because of this and its high energy density, it has been attracting more and more attention during the last few decades. Uranium is a valuable nuclear fuel used in the majority of nuclear power plants. More than one thousand times more uranium exists in the oceans, at very low concentrations, than is present in terrestrial ores. As the demand for nuclear power generation increases year-on-year, access to this reserve is of paramount importance for energy security. Water-insoluble polymeric materials functio

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27

Bolotin, Dmitrii S., Marina Ya Demakova, Anton A. Legin, et al. "Amidoxime platinum(ii) complexes: pH-dependent highly selective generation and cytotoxic activity." New Journal of Chemistry 41, no. 14 (2017): 6840–48. http://dx.doi.org/10.1039/c7nj00982h.

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The reaction ofcis-[PtCl<sub>2</sub>(Me<sub>2</sub>S̲O)<sub>2</sub>] with amidoximes RC(NH<sub>2</sub>)NOH results in selective generation of two types of complexes,viz.open-chain and chelated, depending on the reaction media.

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28

Filimonov, Aleksandr, Anastasia Diveikina, Yuri Gatilov, Olga Luzina, and Nariman Salakhutdinov. "Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid." Molbank 2024, no. 4 (2024): M1912. http://dx.doi.org/10.3390/m1912.

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Diffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reaction of diffractaic acid with amidoximes.

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29

Presnukhina, Sofia I., Marina V. Tarasenko, Kirill K. Geyl, et al. "Unusual Formation of 1,2,4-Oxadiazine Core in Reaction of Amidoximes with Maleic or Fumaric Esters." Molecules 27, no. 21 (2022): 7508. http://dx.doi.org/10.3390/molecules27217508.

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We have developed a simple and convenient method for the synthesis of 3-aryl- and 3-hetaryl-1,2,4-oxadiazin-5-ones bearing an easily functionalizable (methoxycarbonyl)methyl group at position 6 via the reaction of aryl or hetaryl amidoximes with maleates or fumarates. The conditions for this reaction were optimized. Different products can be synthesized selectively in good yields depending on the base used and the ratio of reactants: substituted (1,2,4-oxadiazin-6-yl)acetic acids, corresponding methyl esters, or hybrid 3-(aryl)-6-((3-(aryl)-1,2,4-oxadiazol-5-yl)methyl)-4H-1,2,4-oxadiazin-5(6H)

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30

Agirbag, Hikmet, Dogan Sümengen, Yaşar Dürüst, and Nedime Dürüst. "The Reaction of Amidoximes with Chloroacetyl Chloride." Synthetic Communications 22, no. 2 (1992): 209–17. http://dx.doi.org/10.1080/00397919208021295.

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31

Bolotin, D. S. "Reactions of Amidoximes with Metal-Activated Nitriles." Russian Journal of Coordination Chemistry 44, no. 4 (2018): 243–51. http://dx.doi.org/10.1134/s1070328418040024.

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32

Baykov, Sergey, Artem Semenov, Marina Tarasenko, and Vadim P. Boyarskiy. "Application of amidoximes for the heterocycles synthesis." Tetrahedron Letters 61, no. 42 (2020): 152403. http://dx.doi.org/10.1016/j.tetlet.2020.152403.

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33

Katritzky, Alan R., Niveen M. Khashab, Nataliya Kirichenko, and Anamika Singh. "Microwave-Assisted Preparations of Amidrazones and Amidoximes." Journal of Organic Chemistry 71, no. 24 (2006): 9051–56. http://dx.doi.org/10.1021/jo061410u.

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34

Novikov, Alexander S., and Dmitrii S. Bolotin. "Tautomerism of amidoximes and other oxime species." Journal of Physical Organic Chemistry 31, no. 3 (2017): e3772. http://dx.doi.org/10.1002/poc.3772.

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35

ANDREICHIKOV, YU S., S. G. PITIRIMOVA, and I. V. KRYLOVA. "ChemInform Abstract: Reaction of Aroylketenes with Amidoximes." ChemInform 23, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.199220053.

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36

KAUGARS, G., and W. WATT. "ChemInform Abstract: Reactions of Amidoximes with Orthoacetates." ChemInform 24, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199338243.

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37

Möhrle, Hans, та Jürgen Lessel. "Ν,Ν-Disubstituierte Amidoxim-Nachbargruppen in Cyclodehydrierungen / Assistance of Ν,Ν-Disubstituted Amidoximes in Cyclodehydrogenation Reactions". Zeitschrift für Naturforschung B 47, № 9 (1992): 1333–40. http://dx.doi.org/10.1515/znb-1992-0920.

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o-(tert-Amino)benzamidoximes 6, Ν,Ν-disubstituted at the amid-N-atom of the nucleophilic moiety, are suitable neighbouring groups in cyclodehydrogenation reactions of tertiary amines using mercury(II)-edta. The kind of the N-substituents and the amount of oxidizing agent control the nature of the products, lactams 9 and anellated nitrones 8. The configuration of the tricyclic systems is determined by NMR spectroscopic methods. During the reaction an inversion of the configuration of the oxime moiety occurs, which is explained by an electrocyclic mechanism.

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38

Sauer, André C., Lucas Wolf, Natália Quoos та ін. "A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach". Journal of Chemistry 2019 (16 січня 2019): 1–9. http://dx.doi.org/10.1155/2019/8589325.

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A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.

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39

Tinant, Bernard, Janine Dupont-Fenfau, Jean-Paul Declercq, Jaroslav Podlaha, and Otto Exner. "Configuration on the C=N double bond of monosubstituted amidines and amidoximes." Collection of Czechoslovak Chemical Communications 54, no. 12 (1989): 3245–52. http://dx.doi.org/10.1135/cccc19893245.

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Configuration on the C=N double bond of amidines and amidoximes is controlled by steric effects on the second nitrogen atom but there is a difference in the case of N’-monosubstituted derivatives: amidines prefer E configuration (conformation around the C-N bond sp) and amidoximes Z configuration (conformation ap). This was confirmed by the X-ray structures of two analogous model compounds N,N’-dimethyl-4-nitrobenzamidine (monoclinic, P21c, a = 10.855(3), b = 11.043(3), c = 8.593(3) Å, β = 105.69(2)°, V = 991.8(5) Å3, Z = 4, Dx = 1.29 g cm-3, CuKα, λ = 1.5418 Å, μ = 7.91 cm-1, F(000) = 408, T

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40

Markov, Andrey V., Aleksandra V. Sen’kova, Irina I. Popadyuk та ін. "Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo". International Journal of Molecular Sciences 21, № 10 (2020): 3511. http://dx.doi.org/10.3390/ijms21103511.

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A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3′-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1′,2′,4′-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid’s carboxyl group with corresponding amidoximes and further cyclization. Screening of the cytotoxicity of novel GA derivatives on a panel of tumor cell lines showed that the 3-acetoxy triterpenoid intermediates—O-acylated amidoxime 3a-h—display better solubility under bioassay conditions and more pronounced cytotoxicity compared to their 1′,2′,4′-oxadiazole analogs 4f-h (median IC

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41

Deshmukh, Swapnil S., Sameerana N. Huddar, Dinesh S. Bhalerao, and and Krishnacharya G. Akamanchi. "Oxidation of amidoximes with IBX and IBX/ TEAB." Arkivoc 2010, no. 2 (2010): 118–26. http://dx.doi.org/10.3998/ark.5550190.0011.209.

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42

Mahajan, Umesh S., Rupesh R. Godinde, and P. N. Mandhare. "Preparation of Amidines from Amidoximes via Transfer Hydrogenation." Synthetic Communications 41, no. 15 (2011): 2195–99. http://dx.doi.org/10.1080/00397911.2010.488307.

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43

Sanguineti, Gabriella, Hoang V. Le, and Bruce Ganem. "Studies on the synthesis of amidoximes from nitroalkanes." Tetrahedron 67, no. 52 (2011): 10208–11. http://dx.doi.org/10.1016/j.tet.2011.09.147.

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44

Baykov, Sergey V., Aleksey A. Zharov, Galina A. Stashina, Igor V. Zavarzin, and Evgeniy R. Kofanov. "Reaction of amidoximes with acetonitrile at high pressure." Mendeleev Communications 26, no. 3 (2016): 264–65. http://dx.doi.org/10.1016/j.mencom.2016.05.015.

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45

MOEHRLE, H., K. BLUHME-HENSEN, B. MIDDELHAUVE, D. MOOTZ, and H. WUNDERLICH. "ChemInform Abstract: Cyclization of Amidoximes with Oxybis(diphenylborane)." ChemInform 22, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199151240.

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46

KORBONITS, D., and K. HORVATH. "ChemInform Abstract: Synthesis of Heterocycles from Amino Amidoximes." ChemInform 25, no. 42 (2010): no. http://dx.doi.org/10.1002/chin.199442305.

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47

Kysil, Andrii, Angelina Biitseva, Oleksandra Bugera, Tetyana Yegorova, and Zoia Voitenko. "Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones." French-Ukrainian Journal of Chemistry 8, no. 2 (2020): 176–82. http://dx.doi.org/10.17721/fujcv8i2p176-182.

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Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.

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48

Mehmood, Hina, Muhammad Asif Iqbal, Le Lu, and Ruimao Hua. "Base-Promoted Annulation of Amidoximes with Alkynes: Simple Access to 2,4-Disubstituted Imidazoles." Molecules 25, no. 16 (2020): 3621. http://dx.doi.org/10.3390/molecules25163621.

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An efficient construction of imidazole ring by a Cs2CO3-promoted annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synthetic route with high atom-utilization for the synthesis of 2,4-disubstituted imidazoles in good yields under transition-metal-free and ligand-free conditions. Internal alkynes can also undergo the annulation to give 2,4,5-trisubstituted imidazoles.

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49

Rajesh, O. Bora, and Farooqui Mazahar. "Synthesis of 3,5-disubstituted [1,2,4]-oxadiazoles." Journal of Indian Chemical Society Vol. 85, May 2008 (2008): 569–73. https://doi.org/10.5281/zenodo.5816556.

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Wockhardt Research Centre, Chikalthana, Aurangabad-431 210, Maharashtra, India <em>E-mail :</em> rajeshobora@yahoo.com Aurangabad College for Women, Navkhanda, Aurangabad-431 001, Maharashtra. India <em>Manuscript received 4 June 2007. revised 5 December 2007. accepted 6 March 2008</em> Substituted amidoximes have been synthesized, and converted to corresponding oxadiazoles as a novel heterocyclic compounds under mild conditions in good to excellent yield.

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50

Ölmez, Nevin Arıkan, and Faryal Waseer. "New Potential Biologically Active Compounds: Synthesis and Characterization of Urea and Thiourea Derivativpes Bearing 1,2,4-oxadiazole Ring." Current Organic Synthesis 17, no. 7 (2020): 525–34. http://dx.doi.org/10.2174/1570179417666200417112106.

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Background: Urea, thiourea, and 1,2,4-oxadiazole compounds are of great interest due to their different activities such as anti-inflammatory, antiviral, analgesic, fungicidal, herbicidal, diuretic, antihelminthic and antitumor along with antimicrobial activities. Objective: In this work, we provide a new series of potential biologically active compounds containing both 1,2,4-oxadiazole and urea/thiouprea moiety. Materials and Methods: Firstly, 5-chloromethyl-3-aryl-1,2,4-oxadiazoles (3a-j) were synthesized from the reaction of different substituted amidoximes (2a-j) and chloroacetyl chloride i

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