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Dissertations / Theses on the topic 'And Clinical Applications'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tate, S. K. "Clinical applications of pharmacogenetics." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446133/.

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The field of pharmacogenetics has grown rapidly over the last few years yet, with a couple of exceptions, pharmacogenetic diagnostics are not yet used in a clinical setting. Progress in the field is discussed and the current state of pharmacogenetic research is assessed in a literature review. This thesis describes studies to investigate the pharmacogenetics of the anti-epileptic drugs phenytoin, carbamazepine and levetiracetam, using data obtained from the routine clinical use of these drugs, and the pharmacogenetics of the beta-blocker bucindolol in a clinical trial setting. Evidence is pres

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2

Chopra, S. "Clinical applications of Goodpasture antigen." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592246.

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Goodpasture's disease is a well described autoimmune disorder characterised by rapidly progressive glomerulonephritis and pulmonary haemorrhage. The antigen had been identified as the carboxyl terminal of the non-collagenous domain of the α3 chain of type IV collagen, α3(IV)NC1. This has been successfully expressed as a recombinant minichain construct in insect cells. This project investigates ways in improving the production and purity of the recombinant antigen as well as probing possible clinical uses for the recombinant product, rAg. A minichain construct expressing α4(IV)NC1 was developed

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3

Bravi, Andrea. "Variability Monitoring for Clinical Applications." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31116.

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Current monitoring tools in the intensive care units focus on displaying physiologically monitored parameters (e.g. vital signs such as heart rate, respiratory rate and blood pressure) at the present moment. Added clinical utility can be found by analyzing how the conditions of a patient evolve with time, and automatically relating that dynamics to population trends. Variability analysis consists of monitoring patterns of variation over intervals in time of physiological signals such as heart rate and respiratory rate. Given that illness has been associated in multiple studies with altered var

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4

TOSCO, VINCENZO. "Nanotechnological applications in clinical dentistry." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/290680.

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Al giorno d'oggi, i progressi delle nanotecnologie hanno rivoluzionato drasticamente tutti i campi dell'odontoiatria, dalle malattie orali alla diagnosi, prevenzione e trattamento. Lo scopo di questa tesi di dottorato è stato quello di indagare e valutare l'applicazione delle nanotecnologie nella pratica clinica, con particolare attenzione all'Odontoiatria Preventiva, Estetica e Restaurativa. La prevenzione della carie e il trattamento precoce delle lesioni sono sfide prioritarie per il clinico. Il design basato su nanomateriali, che include idrossiapatite sintetica o suoi derivati, è in grad

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5

Yang, Xiangyu. "Quantitative Approaches in MRI with Clinical Applications." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211393381.

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6

Sedayo, Anas. "Clinical applications of the Medipix detector." Thesis, University of Canterbury. Physics and astronomy, 2012. http://hdl.handle.net/10092/7229.

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In this thesis a recently developed energy resolving x-ray detector (Medipix) is used to investigate potential medical applications of spectral x-ray imaging. Computed Tomography (CT) is one of the most important medical imaging modalities. Recent developments in CT techniques include dual-energy CT, where images are taken with two different x-ray spectra by either using two x-ray tubes operated at different voltages, or modulating the operating voltage of a single tube. These techniques provide spectral information in the CT dataset but are limited to what can be achieved by manipulating the

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7

Corradini, Paula L. "CLINICAL APPLICATIONS OF THE QUANTITATIVE ELECTROENCEPHALOGRAPH." Thesis, Laurentian University of Sudbury, 2014. https://zone.biblio.laurentian.ca/dspace/handle/10219/2154.

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Clinical psychology is a discipline that assesses and treats individuals experiencing a variety of psychological disorders; including brain injuries. Employing neuroimaging tools can reveal biological correlates that have not been previously studied in detail. The quantitative electroencephalograph (QEEG) is a dynamic neuroimaging tool that allows for the measurement of brain activity. QEEG source localization analysis has provided additional construct validity for neuropsychological tests by revealing increased activation in the associated brain regions. In addition, differences in resting br

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8

Abraha, Hagosa Demoz. "Clinical applications of circulating S100B protein." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426060.

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9

Quraishi, Tanviha. "Clinical applications of Electrical Impedance Tomography." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/clinical-applications-of-electrical-impedance-tomography(bfe18e6f-e9e3-49ff-9f5b-4b0bbf72c575).html.

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Introduction: Electrical Impedance Tomography (EIT) is an emerging clinical imaging technique. Functional EIT by Evoked Response (fEITER) was developed at the University of Manchester as a high-speed, functional brain imaging device for use at the bedside. This 32-electrode EIT system applies an injection frequency of 10kHz and captures data using a 10ms temporal resolution. This thesis reports on the first volunteer and patient trials undertaken using fEITER for the following conditions: (a) flashing visual sequence - 14 awake volunteers; (b) a voluntary Valsalva manoeuvre (VM) - 15 awake vol

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10

Hasegawa, Satoshi. "CLINICAL APPLICATIONS OF ELECTRICAL MUSCLE STIMULATION." Kyoto University, 2011. http://hdl.handle.net/2433/142294.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第16166号<br>人博第549号<br>新制||人||133(附属図書館)<br>22||人博||549(吉田南総合図書館)<br>28745<br>京都大学大学院人間・環境学研究科共生人間学専攻<br>(主査)教授森谷敏夫, 教授津田謹輔, 准教授林達也<br>学位規則第4条第1項該当

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11

Yang, Kylie. "Towards Fluorescent Tools for Clinical Applications." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24542.

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As our understanding of molecular biology broadens, we gain a deeper understanding of the molecular signatures and microenvironments associated with disease. In conjunction, better understanding of activatable fluorophores and the chemical transformations that occur within biological systems has enabled the development of numerous molecular probes and sensors. It is now possible to selectively sense chemical species associated with disease and use biochemical transformations to create activatable therapeutics. Through rational design, it is possible to build tailored molecular tools with fi

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12

Smurzynski, Jacek. "New Clinical Applications of Otoacoustic Emissions." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2158.

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13

Alonci, Giuseppe. "Injectable hydrogels for innovative clinical applications." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF064.

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Cette thèse porte sur la conception d'hydrogels injectables pouvant être utilisés en chirurgie mini-invasive, par exemple en dissection endoscopique sous-muqueuse (ESD) ou en réparation de hernie.Les polyamidoamines (PAAm) constituent une classe d'hydrogel intéressante à ces fins. Après avoir étudié les différents facteurs qui affectent leurs propriétés, nous montrons qu'il est également possible d'obtenir des microgels à base de PAAm pour la délivrance de médicaments ou l'encapsulation de cellules. Il est possible de synthétiser des PAAm dégradables qui peuvent être injectés dans la sous-muqu

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14

Ciulla, M. M. "Ultrasonic myocardial tissue characterization: clinical applications." Doctoral thesis, Università degli Studi di Milano, 2001. http://hdl.handle.net/2434/49004.

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15

Mestres, Bea Gemma. "Novel phosphate-based cements for clinical applications." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/101393.

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This Thesis aims at the development of two novel families of inorganic phosphate cements with suitable characteristics for clinical applications in hard tissue regeneration or replacement. It is organized in two distinct parts. The first part focuses at the development of silicon-doped a-tricalcium phosphate and the subsequent preparation of a silicon-doped calcium phosphate cement for bone regeneration applications. For this purpose, silicon-doped a-tricalcium phosphate was synthesized by sintering a calcium-deficient hydroxyapatite at 1250ºC with different amounts of silicon oxide. The hig

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16

Bunce, Nicholas Harry. "Clinical applications of coronary cardiovascular magnetic resonance." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409417.

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17

Nilsson, Anders. "Power Doppler - Principles and Potential Clinical Applications." Doctoral thesis, Uppsala : Institutionen för onkologi, radiologi och klinisk immunologi : Uppsala universitet, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3775.

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18

Ostrovska, Alexsandra. "Vestibular evoked myogenic potentials in clinical applications." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80345.

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It is uncertain whether clinically useful information of otolith function can be well characterized by vestibular-evoked-myogenic-potentials (VEMPs), i.e., electromyogenic activity recorded from sternomastoid muscles in response to brief loud auditory clicks. We aimed to assess the utility of VEMP testing in the differential diagnosis of dizziness (81 dizzy patients, 12 normals). We found that: (1) VEMP was reliably elicited from all controls and from 96% of patients without loss of vestibular function; (2) in patients with documented unilateral peripheral vestibular disorders, VEMP cou

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19

Gilchrist, Sophie Louise. "Clinical applications of errors-in-variables methodology." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/54075/.

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A further assumption made by these methods is that of assuming knowledge of the error variance. Theoretical results are presented with respect to estimating all the model parameters from a single study dataset. An investigation into the practical elements of this theoretical work is presented, concluding that there is not enough information within the data to practically estimate all the model parameters.

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20

John, W. G. "Glycated proteins : Their measurement and clinical applications." Thesis, De Montfort University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376968.

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21

Byers, Robert. "Clinical applications of angiographic optical coherence tomography." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/21904/.

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Angiographic optical coherence tomography (OCTA) has rapidly found utility within many facets of medical research. Here OCTA algorithms are enabled on a commercial OCT system and verified through correlation with intra-vital light microscopy (IVM). While the vast majority of vessels were accurately measured, smaller vessels (< 30μm) have a tendency to appear dilated in comparison to IVM. The technique was also expanded upon to facilitate the imaging of subcutaneous murine fibrosarcoma tumours, negating the requirement for an intra-vital window. It was found that vessel measurement sensitivity

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22

Hotton, Matthew. "The clinical applications of working memory training." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:62a7a411-9624-4fc6-9330-3a279013db42.

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Working memory is involved in a variety of cognitive tasks, with working memory capacity predicting an individual's ability to process information and focus attention on taskrelated information. Subsequently, recent research has investigated whether working memory capacity can be improved through training and whether improvements generalise to other cognitive, behavioural or emotional domains. This training is typically adaptive in nature, changing in difficulty according to participant ability, and can be completed in the participant's home on a computer, giving it the potential to be an easi

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23

SAUSER, FRANK EDWARD. "PACKAGING OF PRESSURE MICROSENSORS FOR CLINICAL APPLICATIONS." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109368416.

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24

Bulale, Yusuf. "Flexible tactile digital feedback for clinical applications." Thesis, Aston University, 2014. http://publications.aston.ac.uk/23646/.

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Trauma and damage to the delicate structures of the inner ear frequently occurs during insertion of electrode array into the cochlea. This is strongly related to the excessive manual insertion force of the surgeon without any tool/tissue interaction feedback. The research is examined tool-tissue interaction of large prototype scale (12.5:1) digit embedded with distributive tactile sensor based upon cochlear electrode and large prototype scale (4.5:1) cochlea phantom for simulating the human cochlear which could lead to small scale digit requirements. This flexible digit classified the tactile

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25

Chan, Kin Foong. "Pulsed infrared laser ablation and clinical applications /." Digital version:, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992765.

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26

Moriarty, Tom. "Self-concept : alternative perspectives and clinical applications." Thesis, Bangor University, 2002. https://research.bangor.ac.uk/portal/en/theses/selfconcept-alternative-perspectives-and-clinical-applications(e75d2c85-6fb7-420e-a304-321e4a19c39a).html.

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This thesis examined self-concept from both a theoretical and applied perspective. It is written as a series of research papers, each of which investigates a specific aspect of this topic. These papers are preceded in Chapter 1 by a comprehensive review of the most relevant research in this area of empirical investigation. The most significant development in self-concept research over recent years has been the shift from a unidimensional model to a multidimensional model that is hierarchically organised. However, this hierarchical structure has received weak empirical support. The study in Cha

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27

SAGGESE, IGOR. "NGS data analysis approaches for clinical applications." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/86924.

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28

Fry, Ian David Robert. "Oxalate analysis and its applications." Thesis, University of Surrey, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292296.

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29

Nagaraj, Nagarjuna. "Developing mass spectrometry towards applications in clinical proteomics." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-134131.

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30

Blystad, Ida. "Clinical Applications of Synthetic MRI of the Brain." Doctoral thesis, Linköpings universitet, Avdelningen för radiologiska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143032.

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Magnetic Resonance Imaging (MRI) has a high soft-tissue contrast with a high sensitivity for detecting pathological changes in the brain. Conventional MRI is a time-consuming method with multiple scans that relies on the visual assessment of the neuroradiologist. Synthetic MRI uses one scan to produce conventional images, but also quantitative maps based on relaxometry, that can be used to quantitatively analyse tissue properties and pathological changes. The studies presented here apply the use of synthetic MRI of the brain in different clinical settings. In the first study, synthetic MR imag

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31

Visioli, Andrew. "High intensity focused ultrasound : applications in clinical oncology." Thesis, Institute of Cancer Research (University Of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422332.

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32

Wang, Silun. "Clinical applications of cardiac multi-detector computed tomography." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36944087.

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33

Maltez, José Carlos. "Quantitative EEG analysis : temporal variability and clinical applications /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-522-4/.

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34

Ng, Kwok-chai Kelvin. "Clinical applications of radiofrequency ablation for hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557674.

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35

Ng, Wai-man. "Anterolateral thigh flap flap design and clinical applications /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558538.

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36

Schuurman, Timothy. "Developments and clinical applications in diagnostic molecular microbiology." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13137.

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37

Smellie, W. Stuart A. "Clinical applications of an assay for intact proinsulin." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308805.

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38

Toms, Gill. "Applications of family-centred care in clinical practice." Thesis, Bangor University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540738.

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39

Scott, Daniel F. "DEVELOPMENT OF LUMINESCENT SENSING SYSTEMS WITH CLINICAL APPLICATIONS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/184.

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As the move towards the miniaturization of many diagnostic and detection systems continues, the need for increasingly versatile yet sensitive labels for use in these systems also grows. Luminescent reporters provide us with a solution to many of the issues at hand through their unique and favorable characteristics. Bioluminescent proteins offer detection at extremely low concentrations and no interference from physiological fluids leading to excellent detection limits, while the vast number of fluorescent proteins and molecules available allows the opportunity to select a tailored reporter for

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40

倪淑慧 and Suk-wai Cora Ngai. "Clinical applications of misoprostol in obstetrics and gynecology." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31981720.

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41

Tang, Oi-shan, and 鄧靄珊. "The clinical applications of sublingual misoprostol in gynaecology." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30243749.

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42

李福東 and Fook-tung Lee. "Potential clinical applications of bilirubin protein binding studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B31208253.

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43

Wang, Silun, and 王思倫. "Clinical applications of cardiac multi-detector computed tomography." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36944087.

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44

Ng, Kwok-chai Kelvin, and 吳國際. "Clinical applications of radiofrequency ablation for hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557674.

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45

Ng, Wai-man, and 吳偉民. "Anterolateral thigh flap: flap design and clinical applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558538.

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46

Hellmuth, Christian. "LC-MS/MS applications in Targeted Clinical Metabolomics." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168254.

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47

Lumpaopong, Punyawan. "Patellofemoral joint biomechanics : computational modelling and clinical applications." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/27286.

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The patellofemoral joint (PFJ) plays an important role in the extensor mechanism of the knee. Several types of PFJ disorders are commonly found in about 25% of the people. It is believed that patellofemoral (PF) disorders, e.g. excessive lateral pressure syndrome and patellar maltracking, may be associated with articular cartilage contact pressure elevation, which accelerates degenerative joint disease and causes anterior knee pain. To reduce the pressures, a number of anatomical interventions have been applied to correct contact mechanics and patellar tracking. However, the rate of successful

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48

Xi, Jiahe. "Cardiac mechanical model personalisation and its clinical applications." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:0db4cf52-4f64-4ee0-8933-3fb49d64aee6.

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An increasingly important research area within the field of cardiac modelling is the development and study of methods of model-based parameter estimation from clinical measurements of cardiac function. This provides a powerful approach for the quantification of cardiac function, with the potential to ultimately lead to the improved stratification and treatment of individuals with pathological myocardial mechanics. In particular, the diastolic function (i.e., blood filling) of left ventricle (LV) is affected by its capacity for relaxation, or the decay in residual active tension (AT) whose inhi

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49

Riffe, Matthew Joseph. "Wireless MRI Detector Arrays: Technology & Clinical Applications." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1377183452.

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Ngai, Suk-wai Cora. "Clinical applications of misoprostol in obstetrics and gynecology." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2180638X.

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