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Dissertations / Theses on the topic 'Animal Pharmacy'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Dias, Rita Sofia Seixas. "Medicamentos e terapêutica para animais de companhia : contribuição para o estudo do impacto da dispensa farmacêutica na saúde animal." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16453.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Os animais de companhia assumem um papel cada vez mais marcante no seio das famílias portuguesas, sendo que, de acordo com dados recentes, cerca de 2,151 milhões de portugueses, correspondendo a mais de metade (56%) dos lares do país, dispõem de pelo menos um. Compreensivelmente e em paralelismo ocorreu um aumento da importância atribuída ao bem-estar e saúde animal e da oferta e utilização de medicamentos destinados aos animais de companhia. A dispensa de medicamentos em farmácia comunitária não está livre de problemas existindo r

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2

Underwood, Stephen L. "Studies on the mechanisms of pulmonary inflammation and airway hyperreactivity in animal models of asthma." Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244986.

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3

Bourget, Louis A. "The effects of phenylalanine ammonia-lyase immobilized within artificial cells on the compartmental distribution of amino acids in phenylketonuric rats /." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74364.

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Microencapsulation of the enzyme phenylalanine ammonia-lyase (PAL) was developed for in vivo depletion of systemic phenylalanine (PHE) in Phenylketonuric (PKU) rats. Phenylalanine ammonia-lyase was successfully microencapsulated within artificial cells. The immobilized enzyme had an assayed activity of 20% $ pm$ 4% (Mean $ pm$ S.D.) of the free enzyme in solution. The immobilized enzyme maintained a higher enzyme activity at very low pH compared to the free enzyme in solution. The pH optimum of the free and immobilized enzyme was 8.5. This pH optimum corresponds to the average pH range of the

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4

Cox, Helen Celia. "A biodegradable system for the tailored delivery of growth factors and its application to bone morphogenetic protein-2 delivery for bone repair." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13881/.

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The repair of bone defects and fracture non-unions remain a challenge for clinicians. Current materials have limitations regarding quality, availability and there are long-term complications. Alternative graft materials, often in combination with growth factors have been investigated, but, poor retention of growth factors has lead to the clinical use of high doses and/or frequent injections, putting the patient at risk of adverse effects. The aim was to develop and evaluate a controlled bone morphogenetic protein-2 (BMP-2) delivery system based on poly(lactide-co-glycolide) (PLGA) that would i

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5

Marshall, Paul. "The internal properties of the bioadhesive bond." Thesis, University of Nottingham, 2000. http://eprints.nottingham.ac.uk/11460/.

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The movement and concentration of water inside hydrophilic matrices and the bioadhesive bonds formed by them have been proposed as important factors in the bioadhesion of hydrophilic matrices (Smart et al, 1991, and Mortazavi and Smart, 1993). This thesis has developed a non-invasive magnetic resonance imaging (MRI) technique to spatially resolve the self-diffusion coefficient (SDC) and concentration profiles of water inside the bioadhesive bonds formed by dry and hydrated hydrophilic matrices. The bioadhesive interaction between mucin and adhesive may affect the network structure and diffusio

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6

Madeira, do Ó. João. "Applications of glycopolymer libraries as protein aggregation modulators and drug delivery systems." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38014/.

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The biopharmaceutical market has been on the rise for the past two decades and is expected to continue to excel, currently presenting a growing rate of more than double than conventional pharma. Traditionally this growth has been hindered by multiple formulation issues such as poor bioavailability and poor stability. Consequently, the drive to optimise the stability of protein drug candidates via formulation impels the need for development of novel excipients. Novel glycopolymer excipients were reported to confer improved protein stability in selected cases. Nonetheless,their structure-functio

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7

Pettit, Wendy Marie. "Towards the development of a multicomponent, nanoscale oral vaccine delivery system targeting infectious bursal disease (IBD)." Thesis, University of Greenwich, 2013. http://gala.gre.ac.uk/11376/.

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As the global population increases, estimated to reach 9 billion by the year 2050, global food security becomes a priority. A prominent disease implicated in financial loss to the poultry industry, on a global scale, is infectious bursal disease virus (IBDV). Vaccination against IBDV is sub-optimal and difficult to deliver. Therefore it has been highlighted as a key area for the development of an oral vaccine. A highly conserved capsid protein from IBDV (VP2) was identified, and sub-cloned into a bacterial expression cassette. This protein was fused to a potential carrier protein (cholera toxi

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8

Tang, Huadong. "Allometric scaling for predicting human drug clearance." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/290158.

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Various modified methods have been proposed in response to criticisms regarding the practical applicability of allometric scaling, which is one of the most widely used approaches in predicting human drug clearance based on data from animal species. The major problems encountered among allometric methods in predicting human drug clearance are addressed in this dissertation. In chapter 2, a large data set for allometric scaling (n = 138) was collected from the literature and was categorized according to the following criteria: oral or systemic clearance; elimination routes; protein or non-protei

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9

Fathi, Zainab H. "Development and application of a linear polyamidoamine-SiRNA delivery system." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50082/.

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Spleen tyrosine kinase (Syk) plays a critical role in regulation of immune and inflammatory responses. The important role of Syk in inflammatory signalling cascades has led to the development of therapeutic agents designed to knock down Syk gene as novel therapeutic agents for allergic diseases (1). This thesis investigated the role of siRNA in Syk silencing using the newly developed RBL reporter systems as an in vitro model to study degranulation. Lack of an efficient and safe non-viral delivery systems has hindered the progress of siRNA into clinics. The ideal properties of the siRNA-nanopar

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10

Estey, Chelsie M. "The characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) in rainbow trout (Oncorhynchus mykiss) and the effect of statin drugs on HMGCoAR." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27454.

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The presence of pharmaceuticals in the aquatic environment is a growing area of concern. The objective of this thesis was to examine the effects of statin drugs, a class of pharmaceuticals prescribed to lower endogenous cholesterol production by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR), in the rainbow trout Oncorhynchus mykiss. The study also aimed to provide some insight into mechanisms governing the control of HMGCoAR in fish. Two statin drugs were used in this study, cerivastatin (CVT) and atorvastatin (AVT). Cerivastatin inhibited hepatic microsomal and brain ho

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11

Zhu, Jing. "Polymer-mediated crystallisation of proteins." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/27707/.

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Proteins are the functional machines of nature and play an essential role in life. Understanding the structure and function of proteins is central to numerous areas of science and technology, including biotechnological, pharmaceutical and chemical industries. Protein crystals are an important objective for many researchers, but even though there are many examples of protein crystals reported, there are still many uncertainties in controlling the crystallisation process. In addition, while protein crystals have mostly been obtained for characterisation purposes, there are other applications whe

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12

Sui, Cheng. "Effects of polymeric materials on bacterial aggregation and quorum sensing." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42853/.

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In order to develop novel antibacterial therapies that combine anti-adhesion, anti-quorum sensing and the delivery of conventional antibiotics, the effects of polymers on bacterial aggregation and quorum sensing (QS) were studied. QS is a term used to describe method by which bacteria use chemical signal molecules to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the signal molecules used for QS are therefore a potential means to control bacterial population responses. In this thesis, the ability of the cationic polymers poly

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13

Al-Ghabeish, Manar I. "Drug transporters in the nasal epithelia and their contribution in drug delivery." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1529.

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The nasal route has primarily been used to deliver drugs for the treatment of local diseases such as nasal infections, nasal congestion and allergies. The nasal route can also be used as a non-invasive alternative route to deliver drugs systemically when a rapid onset of action and/or avoidance of hepatic metabolism are desired. Moreover, there is a growing interest in the use of this route for direct transport of drugs from the nose to the brain. Most of the drugs that have been studied for nasal delivery are either small molecules which are lipophilic enough to passively diffuse through the

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14

Bejgum, Bhanu Chander. "Uptake and distribution of ultrafine nanoparticles and microemulsions from the nasal mucosa." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5713.

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Various colloidal delivery systems, including polymeric nanoparticles, metal colloids, liposomes, and microemulsions have been reported to enhance the delivery of therapeutic agents following intranasal administration. However, the mechanisms involved in the uptake of these nanomaterials, especially those in the ultrafine size ranges (diameter < 20 nm) through nasal mucosa and their subsequent biodistribution in the body are not well characterized. The objectives of this study address the knowledge gap regarding ultrafine nanoparticle transfer in the nasal mucosa by quantifying nanoparticle up

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15

Kulkarni, Upendra D. "Optimization of porcine buccal mucosa for in vitro evaluation." Scholarly Commons, 2007. https://scholarlycommons.pacific.edu/uop_etds/652.

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Porcine buccal mucosa has been extensively used as in vitro model to study the permeability of drugs and assess their potential to deliver through buccal route. Porcine buccal mucosa is found to be very similar to human oral mucosa in structure and function. However, the in vitro permeation studies across porcine buccal mucosa show high variability which is mostly due to the various experimental and biological variables that are often overlooked while conducting such studies. The precise nature of the permeability barrier offered by the various tissue layers of buccal mucosa was investigated i

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16

Kostrzewa, Richard M., John P. Kostrzewa, Russell W. Brown, Przemyslaw Nowak, and University of Silesia Ryszard Brus Medical. "Dopamine Receptor Supersensitivity: Development, Mechanisms, Presentation, and Clinical Applicability." Digital Commons @ East Tennessee State University, 2008. https://doi.org/10.1007/BF03033804.

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The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been learned regarding DARSS. For example, overt D1 DARSS occurs after perinatal destruction of nigrostriatal DA fibers. However, following perinatal destruction of DA innervation, the most-prominent behavioral effects of a D1 agonist are observed after a series of D1 agonist treatmen

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17

Fisher, Anthony Neil. "Studies on the nasal absorption of drugs in animals." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240262.

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18

Huang, Yingbo. "Intrapulmonary Inoculation of Multicellular Tumor Spheroids to Construct an Orthotopic Lung Cancer Xenograft Model that Mimics Four Clinical Stages of Non-small Cell Lung Cancer." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3596.

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Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development a

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19

Trameaux, Gilles. "La pharmacie vétérinaire et le pharmacien." Paris 5, 1998. http://www.theses.fr/1998PA05P223.

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20

Adam, Cécile. "Etude des pratiques en antibiothérapie dans la filière poulet de chair Label Rouge." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAC088.

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La lutte contre l’antibiorésistance, à présent reconnue comme un problème public mondial majeur, passe par l’utilisation raisonnée des antimicrobiens. Diminuer leur utilisation est ainsi un défi pour l’agriculture, en particulier pour les productions animales hors sol, dont les espèces figuraient en 2013 en France parmi les plus exposées aux antimicrobiens. La recherche de leviers d’action permettant de réduire l’usage des antibiotiques constitue donc un enjeu important. L’objectif de la thèse était précisément d’identifier des leviers d’action pour diminuer l’usage des antibiotiques, en prena

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21

Sari, Peyami, and n/a. "Isotropic medium chain mono- and diglyceride systems : vehicles for subcutaneous injection in sheep." University of Otago. School of Pharmacy, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070405.160443.

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Purpose: To develop an approach to formulating an injectable solution containing both hydrophilic and lipophilic drugs for subcutaneous administration. Based on the literature survey, isotropic medium chain mono-and diglyceride (MCMDG) systems were chosen for study. For this purpose, analytical methods were developed and validated. In vitro assessments of the MCMDG systems, and in vitro release and in vivo studies were conducted. Methods: The phase diagrams of the isotropic MCMDG systems were constructed with systems comprising two and three components. The isotropic region was examined by v

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22

Grosse, Laurent. "Étude de la régulation de la glucuronidation des androgènes par UGT2B15 et UGT2B17 dans la prostate et dans des modèles animaux." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30096/30096.pdf.

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Une dérégulation du métabolisme des androgènes peut induire de graves pathologies comme le CaP (CaP). Pour le traiter, on utilise la thérapie de déprivation en androgène (ADTh). Néanmoins, le CaP s’adaptant, les traitements deviennent inefficaces. Trouver de nouvelles cibles thérapeutiques est donc essentiel. Nous sommes intéressés par la glucuronidation via les enzymes UGT2B15 et UGT2B17, la voie majeure d’inactivation des androgènes. Ce projet de recherche avait deux objectifs. 1) déterminer comment l’expression des UGT2B15 et UGT2B17 est régulée in vivo et in vitro avec ou sans ADTh, 2) cré

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23

Hasibu, Ibrahim. "LE COCHON D'INDE COMME MODÈLE ANIMAL DE BIOTRANSFORMATION DES MÉDICAMENTS : Caractérisation de la sous-famille des cytochromes P450 2C, du transporteur membranaire MDR1 et des récepteurs nucléaires CAR et PXR." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28928/28928.pdf.

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24

Alshabanah, Othman A. "Polyamine and acetylpolyamine levels during phenylhydrazine-induced erythropoiesis in mouse spleen." Scholarly Commons, 1988. https://scholarlycommons.pacific.edu/uop_etds/3406.

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The phenylhydrazine-induced erythropoietic mouse spleen is used as a model system to demonstrate the relationship between tissue growth and polyamine metabolism. Phenylhydrazine produced significant changes in spleen weights, hematocrits and reticulocyte counts in Swiss-Webster mice. The average spleen weight went up from a control of 155 mg to 875 mg at 96 hours after phenylhydrazine administration, while a 49% reduction in the value of hematocrit was observed at 72 hours. Reticulocyte counts in peripheral blood went from 0.8 to 58% at 168 hours after treatment with phenylhydrazine. Phenylhyd

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25

St-Amour, Isabelle. "Effet des IGIV dans des modèles murins de maladies neurodégénératives." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30473/30473.pdf.

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Dans la recherche de traitement efficace contre les maladies neurodégénératives, des stratégies d’immunisation active et passive, visant la clairance des agrégats protéiques ont été proposées. Les immunoglobulines pour injection intraveineuse (IgIV) sont des préparations pharmaceutiques d’immunoglobulines G isolées du plasma de milliers de donneurs sains. Puisque des auto-anticorps naturels contre des protéines pathologiques ont été identifiés dans ces préparations, elles ont été proposées comme alternatives aux immunothérapies et font l’objet d’études cliniques dans le traitement de la maladi

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26

Correll, Jennifer A., Daniel M. Noel, A. Brianna Sheppard, et al. "Nicotine Sensitization and Analysis of Brain-Derived Neurotrophic Factor in Adolescent Beta-Arrestin-2 Knockout Mice." Digital Commons @ East Tennessee State University, 2009. https://doi.org/10.1002/syn.20625.

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Nicotine sensitization and levels of brain-derived neurotrophic factor (BDNF) were analyzed in adolescent beta-arrestin-2 knockout (betaA-2 KO) and wild type (WT) mice. The beta-arrestin-2 protein has been shown to be important in G-protein hydrolysis and receptor internalization. Four- to five-week-old adolescent betaA-2 KO and WT C57/Bl6 mice were administered either nicotine (0.5 mg/kg free base) or saline 10 min before being placed into a locomotor arena on each of 7 (Experiment 1) or 14 (Experiment 2) consecutive days. A nicotine challenge was given 7 days after sensitization was complete

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Brown, Russell W., Marla K. Perna, Daniel M. Noel, Jamie D. Whittemore, Julia Lehmann, and Meredith L. Smith. "Amphetamine Locomotor Sensitization and Conditioned Place Preference in Adolescent Male and Female Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6341.

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Neonatal quinpirole treatment has been shown to produce an increase in dopamine D2-like receptor sensitivity that persists throughout the subject's lifetime. The objective was to analyze the effects of neonatal quinpirole treatment on effects of amphetamine in adolescent rats using locomotor sensitization and conditioned place preference procedures. Sprague-Dawley rats were treated with quinpirole (1 mg/kg) or saline from postnatal days (P)1 to P11 and raised to adolescence. For locomotor sensitization, subjects were given amphetamine (1 mg/kg) or saline every second day from P35 to P47 and we

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28

Guérin-El, Khourouj Valérie. "Mise au point d'un modèle murin de sensibilisation à la phospholipase A2 de venin d'abeille : administration orale de microsphères chargées en allergène aux souris préalablement sensibilisées : étude de la modulation immunologique induite." Paris 11, 2001. http://www.theses.fr/2001PA114816.

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29

PAYS, PALETTE CATHERINE. "Le metabolisme de l'antipyrine comme modele d'etude de l'activite des cytochromes p-450 hepatiques : contribution a l'etude analytique des differents metabolites et application a l'exploration du metabolisme dans differentes especes animales." Paris 5, 1994. http://www.theses.fr/1994PA05W083.

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30

Ouellet, Mélissa. "La barrière hémato-encéphalique, les transporteurs ABC et la maladie d'Alzheimer." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25310/25310.pdf.

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31

Lagarce, Frédéric. "Développement d'une forme à libération prolongée destinée aux traitements chroniques par voie intrathécale : application aux microsphères de baclofène en vue du traitement des spasticités sévères." Angers, 2004. http://www.theses.fr/2004ANGE0503.

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L'administration chronique, de substances neuro-actives aux structures spinales, ne peut être aujourd'hui réalisée que grâce à des pompes implantées dans le corps du patient et reliées à des cathéters spinaux. Cette technique comporte des inconvénients qui pourraient être évités par implantation d'une forme médicamenteuse qui libérerait la substance active de façon contrôlée pendant plusieurs mois. Après une réflexion sur les différentes pistes poursuivies ces dernières années pour augmenter le temps de résidence de molécules au sein des structures spinales, nous décrivons la fabrication de mi

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32

Pin, Nicolas. "Le lapin et les rongeurs domestiques : le conseil à l'officine." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P061.

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Le, Saux Maryvonne. "Étude des mécanismes d'action de l'estradiol au cerveau de rattes ovariectomisées." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24657/24657.pdf.

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34

Brasnu, Emmanuelle. "Mise au point de modèles cellulaires pour l'étude des effets toxicologiques infracliniques de thérapeutiques utilisées en ophtalmologie." Paris 5, 2011. http://www.theses.fr/2011PA05P615.

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Les études récentes en toxicologie oculaire se sont beaucoup intéressées aux effets toxiques des conservateurs contenus dans les préparations ophtalmologiques, en particulier du chlorure de benzalkonium. Or, le programme REACH avec la limitation de l’utilisation d’animaux de laboratoire en toxicologie impose de revoir les outils classiques d’évaluation de la toxicité oculaire et de développer de nouvelles approches. En outre, les principales études in vitro réalisées jusqu’à présent utilisaient comme modèle la lignée épithéliale conjonctivale de Chang présentant l’inconvénient d’un mélange ave

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Bousquet, Mélanie. "Impact des lipides alimentaires dans la maladie de Parkinson : Études chez l'animal." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28860/28860.pdf.

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Lalej-Bennis, Dalila. "Mise au point et évaluation de la voie nasale d'administration de l'insuline dans le traitement du diabète sucré." Paris 5, 1997. http://www.theses.fr/1997PA05S020.

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Apres plus de 10 ans de travaux évaluant les potentialités de l'insuline nasale dans le traitement du diabète sucre, le constat est plutôt négatif : la biodisponibilité est insuffisante et les résultats métaboliques obtenus chez l'homme ne sont pas en rapport avec les espérances des cliniciens. Nous avons repris et complète les travaux de la littérature pour tenter d'améliorer l'efficacité et la tolérance de la formulation nasale et acquérir des données cliniques suffisantes pour conclure sur l'intérêt de l'insuline nasale. Nos résultats montrent que des modifications de la galénique et de la

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Tu, Ly. "Innovation thérapeutique dans la dysfonction endothéliale associée à l'hypertension artérielle pulmonaire." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114823/document.

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L’hypertension artérielle pulmonaire (HTAP) est une maladie grave caractérisée par une obstruction progressive des petites artères pulmonaires, conduisant à une augmentation progressive des résistances vasculaires pulmonaires (RVP) et à terme à une défaillance cardiaque droite et au décès du patient. La vasoconstriction, le remodelage vasculaire pulmonaire, la thrombose in situ et la dysfonction endothéliale sont autant de facteurs qui contribuent au développement et à la progression de la maladie. Ces travaux de doctorat ont visé à préciser et mieux comprendre le phénotype anormal de la cellu

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Phivilay, Alix. "Approches nanotechnologiques et nutraceutiques dans le traitement de la maladie d'Alzheimer." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25317/25317.pdf.

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Archambeaud, Marine. "Substitution éventuelle du stéréate de magnésium d'origine bovine par son homologue d'origine végétale dans la formulation des comprimés." Paris 5, 1999. http://www.theses.fr/1999PA05P068.

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40

Moustafa, Tarek Mohamed Mohamed. "Microencapsulation de cellules chromaffines bovines dans le traitement des douleurs chroniques rebelles : étude de faisabilité in vitro et in vivo." Toulouse 3, 2007. http://thesesups.ups-tlse.fr/45/.

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Le principe de thérapie cellulaire des douleurs chroniques rebelles est de transplanter dans l'espace sous-arachnoïdien des cellules chromaffines pour qu'elles se comportent comme un véritable mini pompes en libérant de manière continue des substances neuroactives telles que les catécholamines et les peptides opioïdes. Mais les transplants xénogéniques dégénèrent progressivement si un traitement immunosuppresseur n'est pas mis en route. Le concept d'immuno-isolement a été proposé pour éviter le traitement immunosuppresseur. Dans ce travail, nous rapportons la microencapsulation des cellules ch

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Ponzoni, Adele Asia. "Development and Application of Mass Spectrometry Methods to Qualify Models and Compounds to Support the Discovery of Small Molecules Modulators of Antigen Presentation." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS059.

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The challenges of drug discovery can be addressed through a multidisciplinary approach that integrates various scientific disciplines. Analytical chemistry has contributed significantly to advances in research and development of new drugs, with mass spectrometry-based techniques being widely applied in this context. The primary objective of this thesis is to support a drug discovery program targeting the endoplasmic reticulum aminopeptidases, ERAP1 and ERAP2, by developing and applying advanced analytical methods, specifically spectrometry imaging (MSI) and liquid chromatography-tandem mass sp

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Igra, Alma. "Farm to Pharmacy: Nutrition, Animals, and Governance in Britain 1870-1945." Thesis, 2020. https://doi.org/10.7916/d8-a0e7-vx11.

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This dissertation examines the emergence of nutrition science in the 20th century and the first cohort of experts who practiced nutrition as a form of medical diplomacy. Unpacking pivotal case studies in Scotland, Iraq, Vienna, Geneva, and Oxford, the project shows how scientific knowledge was produced on a local scale. I argue that knowledge about food developed in Britain from the late 19th century to World War II in a contingent path that involved much more than “discoveries” in labs. It was the unique formation of this discipline across national, international, and imperial political spher

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Jolayemi, Adebayo Taiwo Ezekiel. "Studies on some pharmacological properties of Capsicum frutescens-driven capsaicin in experimental animal models." Thesis, 2012. http://hdl.handle.net/10413/8111.

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The present study investigated pharmacological properties of Capsicum frutescens-derived capsaicin, including its analgesic, anti-inflammatory and coagulatory properties. The effects of capsaicin on gastrointestinal and myocardial muscles, as well as on myocardial ischaemic-reperfusion, were also investigated. Capsaicin pre-treatment in neonatal rats has been found to abolish the development of thermal hyperalgesia produced in a model of neuropathic pain in rats (Toth-Kasa et al., 1986). In addition, capsaicin sensitivity has been found to be dependent on continued presence of nerve growth fac

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Thurman, Graham Duncan. "The pharmacokinetics of phenobarbitone in fasting and non-fasting dogs." Thesis, 1990. http://hdl.handle.net/10413/8141.

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Practicing clinical veterinarians in large companion animal practices are often faced with the phenomena of epileptic seizures which occur commonly in dogs. The high incidence of non-responsive cases is often frustrating, and the literature offers incomplete, conflicting and often inaccurate information. The concept of therapeutic anti-epileptic drug concentration monitoring, as applied in man as an aid to treatment, appears attractive in order to provide an improved service to the patient and client. An investigation into the pharmacokinetics of phenobarbitone, particularly at steady state, b

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Badri, Roopram. "An investigation into the effects and possible mechanisms of action of cimetidine and ranitidine on the sexual behaviour of male rats." Thesis, 1985. http://hdl.handle.net/10413/9574.

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The development of a new class of antihistamines, the H2-receptor antagonists, introduced a new era in the treatment of peptic ulcer diseases. Cimetidine, the first clinically effective H2-blocker, was introduced in 1976. Recently ranitidine, a second member approved for clinical use, has been found to be as effective as cimetidine in the management of peptic ulcer diseases. Soon after the introduction of cimetidine several reports of loss of libido, impotence and gynaecomastia were described in male patients who were on normal or high therapeutic doses of cimetidine. A few unsubstan

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Gohore, Bi Goue D. "Évaluation et contrôle de l'irrégularité de la prise médicamenteuse : proposition et développement de stratégies rationnelles fondées sur une démarche de modélisations pharmacocinétiques et pharmacodynamiques." Thèse, 2010. http://hdl.handle.net/1866/4535.

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L'hétérogénéité de réponses dans un groupe de patients soumis à un même régime thérapeutique doit être réduite au cours d'un traitement ou d'un essai clinique. Deux approches sont habituellement utilisées pour atteindre cet objectif. L'une vise essentiellement à construire une observance active. Cette approche se veut interactive et fondée sur l'échange ``médecin-patient '', ``pharmacien-patient'' ou ``vétérinaire-éleveurs''. L'autre plutôt passive et basée sur les caractéristiques du médicament, vise à contrôler en amont cette irrégularité. L'objectif principal de cette thèse était de

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Gohore, Bi Gouê Denis. "Évaluation et contrôle de l'irrégularité de la prise médicamenteuse : proposition et développement de stratégies rationnelles fondées sur une démarche de modélisations pharmacocinétiques et pharmacodynamiques." Thèse, 2010. http://hdl.handle.net/1866/4535.

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Abstract:

L'hétérogénéité de réponses dans un groupe de patients soumis à un même régime thérapeutique doit être réduite au cours d'un traitement ou d'un essai clinique. Deux approches sont habituellement utilisées pour atteindre cet objectif. L'une vise essentiellement à construire une observance active. Cette approche se veut interactive et fondée sur l'échange ``médecin-patient '', ``pharmacien-patient'' ou ``vétérinaire-éleveurs''. L'autre plutôt passive et basée sur les caractéristiques du médicament, vise à contrôler en amont cette irrégularité. L'objectif principal de cette thèse était

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