Relevant bibliographies by topics / Anti-Cox-2 drugs

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Anti-Cox-2 drugs'

Author: Grafiati
Published: 10 September 2021
Last updated: 29 July 2025

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Journal articles on the topic "Anti-Cox-2 drugs"

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Jackson, Lucina M., and Christopher J. Hawkey. "COX-2 Selective Nonsteroidal Anti-Inflammatory Drugs." Drugs 59, no. 6 (2000): 1207–16. http://dx.doi.org/10.2165/00003495-200059060-00001.

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Sano, Hajime. "2. Nonsteroidal Anti-inflammatory Drugs (COX-2 Selective Inhibitors)." Nihon Naika Gakkai Zasshi 100, no. 10 (2011): 2888–901. http://dx.doi.org/10.2169/naika.100.2888.

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Patrignani, Paola. "Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer." Toxicology Letters 112-113 (March 2000): 493–98. http://dx.doi.org/10.1016/s0378-4274(99)00210-6.

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Reitz, David B., and Peter C. Isakson. "Cyclooxygenase-2 Inhibitors." Current Pharmaceutical Design 1, no. 2 (1995): 211–20. http://dx.doi.org/10.2174/1381612801666220917221427.

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Prostaglandins are synthesized by the enzyme cyclooxygenase (COX), which is the target for nonsteroidal anti-inflammatory drugs (NSAIDs). Recently a second form of COX was discovered (COX-2) that is induced by inflammatory stimuli. The identification of an inducible form of COX led to the hypothesis that COX-2 is responsible for inflammatory prostaglandins, whereas the constitutive COX-I produces physiologically important prostaglandins, e.g., in stomach and kidney. Selective COX- 2 inhibitors have been shown to be anti-inflammatory but do not cause ulcers in the stomach or intestines. It is a
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Khan, Asma A., and Raymond A. Dionne. "The COX-2 inhibitors: new analgesic and anti-inflammatory drugs." Dental Clinics of North America 46, no. 4 (2002): 679–90. http://dx.doi.org/10.1016/s0011-8532(02)00032-0.

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Ishiguro, Hitoshi, and Takashi Kawahara. "Nonsteroidal Anti-Inflammatory Drugs and Prostatic Diseases." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/436123.

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Prostatic diseases are characterized by increased activity of cytokines, growth factors, and cyclooxygenases- (COX-) 1 and 2. Activation of COX-1 and COX-2 results in increased levels of prostaglandins and the induction of angiogenic, antiapoptotic and inflammatory processes. Inhibition of COX enzymes by members of the widely used nonsteroidal anti-inflammatory drug (NSAID) class of drugs decreases prostaglandin production, and exerts a variety of anti-inflammatory, antipyretic, and antinociceptive effects. While numerousin vitro,in vivo, and clinical studies have shown that NSAIDs inhibit the
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Jahnavi, Kasturi, Palla Pavani Reddy, Bakshi Vasudha, and Boggula Narender. "Non-steroidal anti-inflammatory drugs: an overview." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 442–48. http://dx.doi.org/10.22270/jddt.v9i1-s.2287.

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Non-steroidal anti-inflammatory drugs (NSAIDs) including both traditional non-selective NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti-inflammatory and analgesic effects. NSAIDs are a necessary choice in pain management because of the integrated role of the COX path way in the generation of inflammation and in the biochemical recognition of pain. NSAIDs are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effe
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Sondhi, Sham, Shefali Rajvanshi, Nirupma Singh, Shubhi Jain, and Anand Lahoti. "Heterocyclic inflammation inhibitors." Open Chemistry 2, no. 1 (2004): 141–87. http://dx.doi.org/10.2478/bf02476188.

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AbstractNon steroidal anti-inflammatory drugs are the most widely used medicines for relief of pain. These drugs have some side effects, particularly toxicity in the gastrointestinal tract and kidneys. Various approaches have been used for obtaining safer anti-inflammatory drugs. In this review we have summarized the recent developments in the following areas; (i) mode of action of NSAIDs (ii) Role of COX-1 & COX-2 in inflammation, (iii) Different approaches used to improve gastric tolerance i.e. chemical manipulation, formulation & co-administration, development of non specific (COX-1
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Sevinç, Sevgi Koçyiğit, Oya Orun, Pınar Mega Tiber, Pelin Çıkla-Süzgün, and Ş. Güniz Küçükgüzel. "Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines." Proceedings 2, no. 25 (2018): 1573. http://dx.doi.org/10.3390/proceedings2251573.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin synthesis through inhibition of cyclooxygenase (COX) enzymes. Recent studies showed that anti-carcinogenic effects of these drugs are especially mediated by COX-2 enzyme. Etodolac is a COX-2 inhibitor and though not perfectly selective, it exhibits “preferential selectivity” for COX-2. In this study, the anti-proliferative and apoptotic effects of etodolac and its hydrazone or triazole derivatives (SGK 206 and SGK 242, respectively), were inve
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Rao, Praveen, and Edward E. Knaus. "Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond." Journal of Pharmacy & Pharmaceutical Sciences 11, no. 2 (2008): 81. http://dx.doi.org/10.18433/j3t886.

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Purpose. NSAIDs constitute an important class of drugs with therapeutic applications that have spanned several centuries. Treatment of inflammatory conditions such as rheumatoid arthritis (RA) and osteoarthritis (OA) starting from the classic drug aspirin to the recent rise and fall of selective COX-2 inhibitors has provided an enthralling evolution. Efforts to discover an ultimate magic bullet to treat inflammation continues to be an important drug design challenge. This review traces the origins of NSAIDs, their mechanism of action at the molecular level such as cyclooxygenase (COX) inhibiti
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Dissertations / Theses on the topic "Anti-Cox-2 drugs"

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Cunha, Daniela Erica de Horta e. Goes Ribeiro da. "Avaliação da expressão de Cox-2 em tumores mamários da gata por imunohistoquímica : correlação com aspetos clinicopatológicos, classificação histopatológica e possíveis implicações clínicas." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2013. http://hdl.handle.net/10400.5/6098.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A cicloxigenase-2 (Cox-2) é uma enzima que desempenha um papel importante na tumorigénese e encontrando-se sobrexpressa em várias neoplasias humanas, incluindo o cancro da mama. Em medicina veterinária, alguns trabalhos mostram existir uma sobrexpressão da Cox-2 em certas neoplasias da espécie felina, incluindo nos tumores mamários, estando esta associada a pior prognóstico. Tendo em conta estas evidências, a utilização de fármacos anti-Cox-2 como agentes terapêuticos nas neoplasias mamárias é uma hipótese que poderá trazer ben
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Borges, Marina. "Função renal de cães hígidos tratados com anti-inflamatórios não-esteroidais." Universidade do Oeste Paulista, 2011. http://bdtd.unoeste.br:8080/tede/handle/tede/242.

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Made available in DSpace on 2016-01-26T18:55:31Z (GMT). No. of bitstreams: 1 DISSERTACAO.pdf: 506827 bytes, checksum: 85183faa6a63e1b561cacb568f6cf77e (MD5) Previous issue date: 2011-02-24<br>The anti-inflammatory nonsteroidal compounds have extremely widespread use in the therapy of small animals, due to their anti-inflammatory and analgesic properties. However, the use of these drugs can produce changes in kidney function. The present study was conducted to assess kidney function in healthy dogs undergoing therapy with anti-inflammatory nonsteroidal compounds. Thirty mongrel dogs, adults,
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Elliott, Christopher S. "The Chemoprevention of Lung Cancer Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1041537546.

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Gray, Paula Amanda. "The pharmacological profile and theapeutic applications of novel NO-releasing non-steroid anti-inflammatory drugs on the activity of COX-1 and COX-2 in experimental models of inflammation." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396308.

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Bianchetti, érica Silva. "Estudo da interferência de diferentes dietas nutricionais sobre as ações antiinflamatória e analgésica do Etoricoxib (Arcóxia®)." Universidade Jose do Rosario Vellano, 2006. http://tede2.unifenas.br:8080/jspui/handle/jspui/65.

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Made available in DSpace on 2016-05-02T13:54:42Z (GMT). No. of bitstreams: 1 DISSERTACAO COMPLETA ERICA SILVA BIANCHETTI.pdf: 401322 bytes, checksum: d859a5d12a9b16ecd28ee0fecfa86d09 (MD5) Previous issue date: 2006-06-01<br>Conselho Nacional de Desenvolvimento Cientifico e Tecnologico<br>Etoricoxib is a new medicine expected to lead the next generation of selective inhibitors of COX-2 Presently the focus of many clinical assays it is a potent fast-action second generation coxib and the most selective of all The purpose of this study was to evaluate the interference of different nutritional d
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Gunter, Bryan R., Kristen A. Butler, Rick L. Wallace, Steven M. Smith, and Sam Harirforoosh. "NSAIDs-Induced Cardio- and Cerebro-Vascular Adverse Events: a Meta-analysis." Digital Commons @ East Tennessee State University, 2017. https://doi.org/10.1111/jcpt.12484.

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What is known and objective: Although non-steroidal anti-inflammatory drugs (NSAIDs) have been studied in randomized, controlled trials and meta-analyses in an effort to determine their cardiovascular (CV) risks, no consensus has been reached. These studies continue to raise questions, including whether cyclooxygenase-2 (COX-2) selectivity plays a role in conferring CV risk. We performed a meta-analysis of current literature to determine whether COX-2 selectivity leads to an increased CV risk. Methods: We utilized randomized, controlled trials and prospective cohort studies. We selected eight
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Betina-Bencharif, Soumeya. "Isolement et caractérisation de saponosides extraits de deux plantes médicinales : Cyclamen africanum, Zygophyllum cornutum et évalution de leur activité anti-inflammatoire." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOPE03/document.

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L’apparition de plusieurs maladies, telles que le cancer, le diabète, l'hypertension artérielle et la propagation d'infections de type virus mutagènes peuvent être liées à la qualité et au mode de vie que nous menons aujourd’hui. En effet, plusieurs études sur les facteurs déclenchant ces maladies dites "morbides" à long ou à court terme, sont liées au stress et à la qualité des aliments consommés, qu'ils soient d'origine végétale ou animale. Ces maladies deviennent un phénomène courant, elles touchent différentes races et toutes les catégories de la société. D'après les recherches ethnobotani
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Fredriksson, Sundbom Marcus. "Characterisation of anandamide uptake in resting and activated murine cells." Thesis, Umeå universitet, Farmakologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100031.

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Modifying the metabolism of the body’s own endocannabinoids is a novel approach for analgesia. Two key catabolic enzymes are fatty acid amide hydrolase (FAAH) and inflammation-inducible cyclooxygenase 2 (COX-2). The cellular uptake of the key endocannabinoid anandamide (AEA) has been found to be regulated by its FAAH-catalysed intracellular degradation, but COX-2 has not been investigated in this respect. We aimed to find out whether or not COX-2 in an in vitro inflammation setting would be able to gate AEA uptake. To achieve this, C6 cells and Raw 264.7 cells were stimulated with LPS/INF-γ an
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Connolly, Christopher Kevin. "The effects of the preferential COX-2 inhibitor, Meloxicam and motion on fracture healing." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343095.

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Ferguson, Shawn. "Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8909.

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The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX enzyme activity was measured in the M-1 cells, both indomethacin (COX-1 and -2 inhibitor) and the specific COX-2 inhibitor NS-398 effectively blocked PGE2 synthesis. These
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Books on the topic "Anti-Cox-2 drugs"

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Vane, John, Jack Botting, and Regina Botting, eds. Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2.

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Vane, John R. Improved non-steroid anti-flammatory drugs COX-2 enzyme inhibitors: Proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Kluwer Academic Publishers, 1996.

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William Harvey Conference (1995 London, England). Improved non-steroid anti-inflammatory drugs: COX-2 enzyme inhibitors : proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Kluwer Academic, 1996.

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Barragry, Thomas B. N.S.A.I.D.S./toxicity: COX 2 developments. [University College Dublin, Department of Small Animal Studies], 1998.

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Botting, R. M., Jack H. Botting, and Sir John R. Vane. Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer, 2012.

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Botting, Jack H., and Sir John R. Vane. Improved Non-Steroid Anti-Inflammatory Drugs: Cox-2 Enzyme Inhibitors. Island Press, 1996.

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Simon, Lee S., and Marc C. Hochberg. Non-steroidal anti-inflammatory drugs. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0030.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse group of compounds that share three cardinal characteristics: they are anti-inflammatory, analgesic, and antipyretic. They are approved by regulatory authorities for the treatment of patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout, and some forms of juvenile idiopathic arthritis. There are at least 20 chemically different NSAIDs currently available in Europe and the United States. These include not only the ‘traditional’ non-selective cyclooxygenase (COX) inhibitors that inhibit both
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Cheng, Jerry, and David Madigan. Bayesian approaches to aspects of the Vioxx trials: Non-ignorable dropout and sequential meta-analysis. Edited by Anthony O'Hagan and Mike West. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198703174.013.3.

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This article discusses Bayesian approaches to aspects of the Vioxx trials study, with a focus on non-ignorable dropout and sequential meta-analysis. It first provides a background on Vioxx, a COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) approved by the FDA in May 1999 for the relief of the signs and symptoms of osteoarthritis, the management of acute pain in adults, and for the treatment of menstrual symptoms. However, Vioxx was found to cause an array of cardiovascular side-effects such as myocardial infarction, stroke, and unstable angina. As a result, Vioxx was withdrawn fr
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Book chapters on the topic "Anti-Cox-2 drugs"

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Bennett, P., and D. Slater. "COX-2 expression in labour." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_10.

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Vane, J. R., and R. M. Botting. "Overview — mechanisms of action of anti-inflammatory drugs." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_1.

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Patrono, C., P. Patrignani, M. R. Panara, et al. "COX-2 expression and inhibition in human monocytes." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_7.

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Pairet, M., and G. Engelhardt. "Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_6.

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Simmons, D. L., X. Lu, W. S. Bradshaw, and W. Xie. "The dilemma of two cyclooxygenases: identifying the roles of COX-1 and COX-2 in inflammation and apoptosis." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_3.

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Emery, P. "Pharmacology, safety data and therapeutics of COX-2 inhibitors." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_13.

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Pairet, M., L. Churchill, G. Trummlitz, and G. Engelhardt. "Differential Inhibition of Cyclooxygenase-1 (COX-1) and -2 (COX-2) by NSAIDs: Consequences on Anti-Inflammatory Activity Versus Gastric and Renal Safety." In Side Effects of Anti-Inflammatory Drugs IV. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5394-2_23.

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Bateman, D. N. "Re-evaluation of gut toxicity of NSAIDs." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_11.

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Frölich, J. C., and D. O. Stichtenoth. "NSAID: can renal side effects be avoided?" In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_12.

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Garavito, R. M. "The three-dimensional structure of cyclooxygenases." In Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-010-9029-2_2.

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Conference papers on the topic "Anti-Cox-2 drugs"

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Nedeljković, Nikola V., Vladimir D. Dobričić, Marina Ž. Vesović, et al. "In silico estimation of COX-2 and 5-LOX inhibitory potential of some novel thiourea derivatives of naproxen." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.475n.

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Design of dual COX-2/5-LOX inhibitors can be considered an adequate approach in the development of new anti-inflammatory drugs with less pronounced side effects. The aim of the present research was to examine the binding potential of the seven newly designed thiourea derivatives of naproxen towards COX-2 and 5-LOX. The binding analysis of ligand conformations was performed by OEDocking 3.2.0.2 software. The binding potential assessment revealed that thiourea derivatives of naproxen exhibited a comparable binding affinity as naproxen towards COX-2. The highest number of key binding interactions
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Keta, Otilija, Jelena Bošković, Vladana Petković, et al. "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.503k.

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Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, i
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Katanić Stanković, Jelena S., Vanja Todorović, Jelena Đorović Jovanović, et al. "„In vitro“ and „in silico“ assessment of anti-inflammatory activity of cocoa powders." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.156ks.

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Plants are considered the major sources of biologically active compounds, which provide unlimited opportunities for their use either as medical treatments or as novel drug formulations. Cocoa powder is frequently used in nutrition and is known to have many benefits thanks to its wide range of biological activities. The presented study was focused on the evaluation of the anti-inflammatory potential of extracts obtained from cocoa powder. In vitro assays were employed to evaluate the level of inhibition of cyclooxygenases-1 and -2 activities (COX-1 and COX-2) by tested extracts. Molecular docki
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Punganuru, Surendra R., Hanumantha Rao Madala, Constantinos Mikelis, and Kalkunte S. Srivenugopal. "Abstract 4839: Design of a Rofecoxib-Combretastatin hybrid drug that exerts highly potent antimicrotubule, anti-angiogenesis properties and Cox-2 inhibition both in cell culture and xenograft models." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4839.

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Jiménez-Cruz, Juan C., Ramón Guzmán-Mejía, Pedro Navarro-Santos, et al. "Synthesis of Peptide–Nonsteroidal Anti-Inflammatory Drug Hybrid Compounds and Their Selectivity in Inhibiting the Dual Cyclooxygenase-2 (COX)–5-Lipoxygenase (LOX) System: A Docking and Molecular Dynamics Study." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20256.

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