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Journal articles on the topic 'Anti-ulcer agent'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Isobe, Yoshihiko, Yoichi Kiuchi, Haruko Kijita, Makoto Muramatsu, and Susuau Otoao. "Anti-ulcer and anti-secretory effects of SU-840, a novel anti-ulcer agent." Japanese Journal of Pharmacology 64 (1994): 282. http://dx.doi.org/10.1016/s0021-5198(19)50760-0.

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2

Kondo, Isamu, and Masashl Yamaguchi. "Morphological changes of Helicobacter pylori caused in vitro by cytoprotective anti-ulcer drug, Sofalcone." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 620–21. http://dx.doi.org/10.1017/s0424820100160650.

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Since Helicobacter pylori has recently been regarded as a possible causative agent of a chronic gastritis and a peptic ulcer disease, the susceptibilities of this organism to anti-ulcer agents or antibiotics have attracted much interest of not only clinical docters but also medicobiologists.We have reported that Sofalcone, a cytoprotective anti-ulcer drug, has anti-bacterial and bactericidal activity as well as TDS (tripotassium dicitrats bithmuthate) and Clarithromycin (a derivative of erythromycin), but the other anti-ulcer drugs Including anti-acid or H2 receptor antagonists such as cimetid

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3

Dedieu-Chaufour, C., F. Hertz, F. Caussade, and A. Cloarec. "UP 5145-52: A mew anti-ulcer and antisecretory agent." European Journal of Pharmacology 183, no. 2 (1990): 298–99. http://dx.doi.org/10.1016/0014-2999(90)93154-i.

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4

TANAKA, Hisashi, and Shun-ichi NAITO. "Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent." Folia Pharmacologica Japonica 85, no. 5 (1985): 357–66. http://dx.doi.org/10.1254/fpj.85.357.

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5

Zeniya, Akira, Michiro Otaka, Toshiyuki Kuwabara, Shusel Fujimori, Setsuya Otani, and Osamu Masamune. "Anti-Ulcer effect of FK 506, immunosuppressive agent, in rats." Journal of Gastroenterology 29, no. 3 (1994): 383–84. http://dx.doi.org/10.1007/bf02358382.

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6

Matsumoto, Tsuyoshi, Kenichi Sakurai, Asami Tanaka, et al. "The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells." European Journal of Pharmacology 685, no. 1-3 (2012): 213–17. http://dx.doi.org/10.1016/j.ejphar.2012.04.005.

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7

Jhuma, Azima Aktar, Md Moynul Haque, Jamil Ahmed, Shantanu Das, Tarun Kanti Paul, and Md Mahbubur Rahman. "Microbial Agents Causing Infective Corneal Ulcer and their Anti-microbial Susceptibility pattern." Bangladesh Medical Journal 47, no. 2 (2019): 1–6. http://dx.doi.org/10.3329/bmj.v47i2.43502.

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This study was designed to identify the microbial agents causing infective corneal ulcer and to carry out the antimicrobial susceptibility patterns of isolated bacteria causing infective corneal ulcer. Out of 80 samples, 67 (83.75%) cases were positive by microscopy and culture. This study showed pure fungal growth in 39 (48.75%) cases, pure bacterial growth in 8 (10%) cases, mixed microbial growth (both fungi and bacteria) in 20 (25%) cases and no growth was observed in 13 (16.25%) cases. Among the fungal isolates, Aspergillus species was the leading agent detected in 37(46.3%) cases followed

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8

Shigeru, Murakami, Muramatsu Makoto, Aihara Hironaka, and Otomo Susumu. "Inhibition of gastric H+,K+-ATPase by the anti-ulcer agent, sofalcone." Biochemical Pharmacology 42, no. 7 (1991): 1447–51. http://dx.doi.org/10.1016/0006-2952(91)90458-h.

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9

Hoshina, Kenji, Noboru Yamazaki, Hiroaki Mitsuhashi, Toru Takeshita, and Tatsuyuki Naruchi. "A novel anti-ulcer agent, TEI-5103, promotes the gastric mucosal barrier." Japanese Journal of Pharmacology 43 (1987): 232. http://dx.doi.org/10.1016/s0021-5198(19)58499-2.

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10

Kuroki, Akiko Mera, Takashi Kitaoka, Yoko Matsuo, and Tsugio Amemiya. "Inhibition of Experimental Choroidal Neovascularization by Irsogladine, an Anti-Gastric Ulcer Agent." Ophthalmic Research 35, no. 3 (2003): 137–42. http://dx.doi.org/10.1159/000070048.

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11

Javed, Muhammad Ahsan, Mahtab Ahmad Khan, Haroon Arshad, et al. "Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer." RADS Journal of Pharmacy and Pharmaceutical Sciences 8, no. 1 (2020): 47–57. http://dx.doi.org/10.37962/jpps.v8i1.361.

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Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. Omeprazole and ra

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12

Cheng, Die, Mo Liu, Deng-Ke Liu, Ying Liu, and Chang-Xiao Liu. "1-[2-Hydroxy-4-(3-methylbut-2-enyloxy)phenyl]ethan-1-one." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4496. http://dx.doi.org/10.1107/s1600536807053056.

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The title compound, C13H16O3, is an intermediate in the synthesis of the anti-ulcer agent sofalcone. The asymmetric unit contains two independent molecules. Intramolecular O—H...O hydrogen bonds are formed between the carbonyl and hydroxyl groups.

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13

Castillo-Juárez, Israel, and Irma Romero-Álvarez. "Plantas con actividad anti-Helicobacter pylori: una revisión." Botanical Sciences, no. 80 (June 3, 2017): 35. http://dx.doi.org/10.17129/botsci.1744.

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The bacterium Helicobacter pylori is recognized as the main causal agent of active chronic gastritis and peptic ulcer. For many years, traditional medicine has made use of several plants for the treatment of these afflictions; nevertheless, their possible effect upon the bacterium has just begun to be investigated. This study summarizes and analyzes the studies, conducted up to date, of plants with anti-H. pylori activity. It is proposed that their action on H. pylori is mainly directed to the depletion of bacterial population rather than to its eradication, as the current anti-ulcer therapy d

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14

Mochizuki, S., S. Wakabayashi, A. Tomiyama, N. Satake, and S. Shibata. "Thromboxane A2Antagonistic Action of a New Anti-Ulcer Agent, Azuletil Sodium (KT1-32)." Scandinavian Journal of Gastroenterology 24, sup162 (1989): 194–97. http://dx.doi.org/10.3109/00365528909091159.

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15

Saita, Masaru, Takenobu Mizoguchi, Hironobu Sato, Masahiro Nakahara, and Masayoshi Tsuji. "Effects of a new anti-ulcer agent (HAU-102) on experimental gastric ulcers." Japanese Journal of Pharmacology 46 (1988): 289. http://dx.doi.org/10.1016/s0021-5198(19)57707-1.

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16

Saita, Masaru, Tukenubu Mizoguchi, Masahiro Nakahara, Hironubu Sato, and Masayoshi Tsuji. "Effects of a new anti-ulcer agent (HAU-102) on gastric acid secretion." Japanese Journal of Pharmacology 46 (1988): 293. http://dx.doi.org/10.1016/s0021-5198(19)57720-4.

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17

Li, Jun, Xibin Liang, Qian Wang, Richard M. Breyer, Louise McCullough, and Katrin Andreasson. "Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia." Neuroscience Letters 438, no. 2 (2008): 210–15. http://dx.doi.org/10.1016/j.neulet.2008.04.054.

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18

Srivastava, Pratima, and R. C. Gupta. "LC determination of the anti-ulcer agent CDRI-85/92 in rat serum." Journal of Pharmaceutical and Biomedical Analysis 27, no. 6 (2002): 1009–15. http://dx.doi.org/10.1016/s0731-7085(01)00600-8.

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19

Iwasaki, Takanori, and Kazuki Matsunaga. "Nitric oxide-associated vasorelaxing effect of an anti-ulcer agent, benexate hydrochloride betadex." Drug Development Research 36, no. 1 (1995): 13–19. http://dx.doi.org/10.1002/ddr.430360103.

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20

Kaur, Ramandeep, and Kalyan Sen. "Antiulcer activity of hydroalcoholic extract of unripe fruit of carica papaya in experimental rats." International Journal of Basic & Clinical Pharmacology 6, no. 2 (2017): 432. http://dx.doi.org/10.18203/2319-2003.ijbcp20170344.

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Background: Carica papaya has previously reported antioxidant, analgesic and anti-inflammatory, antibacterial and anti-histaminic activity. Peptic ulcer disease involves inflammation and oxidative stress, so hydroalcoholic extract of Carica papaya fruits may have strong potential for an antiulcer agent. Aim and objectives of the study were in this study pharmacological evaluation of antiulcer effect of hydroalcoholic extract of Carica papaya fruits was performed by pyloric ligation induced gastric ulcers.Methods: Preliminary phytochemical investigation, estimation of phenolic and flavonoid con

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21

Pandya, Maitreyi, Anupama N. Kalappanavar, Rajeshwari G. Annigeri, and Dhanya S. Rao. "Relative Efficacy of Quercetin Compared with Benzydamine Hydrochloride in Minor Aphthae: A Prospective, Parallel, Double Blind, Active Control, Preliminary Study." International Journal of Dentistry 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/7034390.

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Background and Objectives. Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Methods. 40 patients with minor aphthous ulcers were divided equally into two groups: A and B. Group A patients were advised to apply quercetin gel and Group B patients were advised to take benzydamine hydr

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22

Masukawa, Yoshikazu, Yosuke Urano, Hiroyuki Hamada, et al. "Effects of a Novel Anti-ulcer Agent Tocoretinate on Acute, Subacute or Chronic Ulcer Models in Rats and Dogs." Japanese Journal of Pharmacology 55 (1991): 85. http://dx.doi.org/10.1016/s0021-5198(19)38265-4.

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23

Ahmad, Md Afroz, Mohd Mujeeb, Mohd Akhtar, Mohd Khushtar, Mohd Arif, and Md Rafiul Haque. "Guggulipid: A Promising Multi-Purpose Herbal Medicinal Agent." Drug Research 70, no. 04 (2020): 123–30. http://dx.doi.org/10.1055/a-1115-4669.

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Herbal medicines therapy is appreciated by many research works because herbal drugs have relatively high therapeutic window, lower side effects and more cost effective. Guggulipid is an ethyl acetate extract of resin known as guggul from the tree Commiphora wightii / mukul (Arn.) Bhandari. Chemical analysis revealed that the compounds responsible for the major activities of gum guggul are the isomers E- and Z-guggulsterone. Guggul has been used for thousands of years in the treatment of arthritis, inflammation, obesity, cardiac protection, anti-ulcer, anti-epileptic and disorders of lipid meta

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24

Inada, Ikuko, Hiroshi Satoh, Nobuhiro Inatomi, Hideaki Nagaya, and Yoshitaka Maki. "Spizofurone, a new anti-ulcer agent, increases alkaline secretion in isolated bullfrog duodenal mucosa." European Journal of Pharmacology 124, no. 1-2 (1986): 149–55. http://dx.doi.org/10.1016/0014-2999(86)90135-4.

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25

Ikeda, Masanori, Yoshinari Kawai, Kyoko Mori, et al. "Anti-ulcer agent teprenone inhibits hepatitis C virus replication: potential treatment for hepatitis C." Liver International 31, no. 6 (2011): 871–80. http://dx.doi.org/10.1111/j.1478-3231.2011.02499.x.

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26

Coroi, Mihaela Cristiana, Liana Todor, Aurel George Mohan, et al. "Treatment with Regenerating Agent Cacicol�." Revista de Chimie 70, no. 5 (2019): 1805–7. http://dx.doi.org/10.37358/rc.19.5.7219.

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The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is demonstrated by numerous pathologies of acute or chronic injury associated with destruction or disruption of its components. Regenerating agent therapy (RGTA) showed a strong anti-oxidative and protective effect resulting in reduced inflammation in chronic periodontitis, corneal lesions, oral and skin ulcers [1-5].Two cases of corneal healing with Cacicol�. The first one was a chemical corneal burn with persistent lesions which resulted in restitutio ad integrum after treatment with Cacicol�. The se

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27

Kongpuckdee, Sonsawan, Suwipa Ungphaiboon, Supreedee Sungkharak, Narubodee Phadoongsombut, and Sirima Mahattanadul. "Efficacy of An Aqueous Morinda citrifolia Fruit Extract-Phytosome Gel in Treating Oral Inflammatory Ulcer in Rabbit Model." Current Pharmaceutical Biotechnology 21, no. 15 (2020): 1699–710. http://dx.doi.org/10.2174/1389201021666200711151925.

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Background: Oral inflammatory ulcers are one of the common complaints of patients attending out-patient clinics. Previous in vivo studies had shown that an Aqueous M. citrifolia Fruit Extract (AMFE) possessed anti-inflammatory and ulcer healing activities. Therefore, a standardized topical bioadhesive gel containing AMFE-phytosome was developed and determined for its oral ulcer healing efficacy in a rabbit model. Methods: The AMFE phytosome (AMFE-P) was prepared by a complexation method with the required amount of AMFE: Phosphatidylcholine: Tween 80 to weigh ratio of 2:1:0.2. Poloxamer 407 was

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28

Satoh, Hiroshi, Kuniko Iwasaki, Nobuhiro Inatomi, Akio Sino, and Yoshitaka Maki. "Effect of spizofurone, a new anti-ulcer agent, on PAF-induced gastric lesions in rats." Japanese Journal of Pharmacology 43 (1987): 231. http://dx.doi.org/10.1016/s0021-5198(19)58496-7.

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29

Yamazaki, Noboru, Hirofumi Tanabe, Masaru Yamamoto, et al. "A novel anti-ulcer agent (TEI-5103) direetly acting on the gastric mucosa from lumen." Japanese Journal of Pharmacology 43 (1987): 232. http://dx.doi.org/10.1016/s0021-5198(19)58500-6.

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30

Bragman, S. G. L., C. L. Pankhurst, and M. W. Casewell. "Activity of sucralfate (sucrose octa-sulphate), an anti-ulcer agent, against opportunistic Gram-negative bacilli." Journal of Antimicrobial Chemotherapy 36, no. 4 (1995): 703–6. http://dx.doi.org/10.1093/jac/36.4.703.

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31

UMEMURA, KAZUO. "Pharmacokinetics of a novel anti-ulcer agent, Z-300 and its action on intragastrine pH." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 25, no. 1 (1994): 239–40. http://dx.doi.org/10.3999/jscpt.25.239.

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32

Keiji, Nishida, Ohta Yoshiji, and Ishiguro Isao. "Teprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats." Japanese Journal of Pharmacology 78, no. 4 (1998): 519–22. http://dx.doi.org/10.1254/jjp.78.519.

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33

Devi, K. Manasa, and Jyothi Y. "Pharmacodynamic interaction of Boerhaavia diffusa with omeprazole in experimentally induced ulcers inrats." Indian Journal of Pharmaceutical and Biological Research 3, no. 01 (2015): 56–63. http://dx.doi.org/10.30750/ijpbr.3.1.9.

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The study evaluates the possible gastro protective of combination therapy of Omeprazole and Boerhaavia diffusa using three different gastric ulcer models. Gastric Ulcers in SD rats were induced by Indomethacin (25mg/kg), Pyrolus ligation model and stress-induced Ulcer. Various parameters like free acidity and total acidity, ulcer index, ulcer score, pepsin and mucin content, anti oxidant parameters like super oxide dismtase and catalase were evaluated. Omeprazole (2mg/kg) was used as the standard drug. Boerhaavia diffusa was administered at two dose levels, 200mg/kg and 400 mg/kg body weight.

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34

Kangwan, Napapan, Komsak Pintha, Suree Lekawanvijit, and Maitree Suttajit. "Rosmarinic Acid Enriched Fraction fromPerilla frutescensLeaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats." BioMed Research International 2019 (March 4, 2019): 1–13. http://dx.doi.org/10.1155/2019/9514703.

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Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source to minimize the effect of the gastric ulcers.Perilla frutescensor Nga-mon (in Thai) leaves are rich in rosmarinic acid (RA), which has antioxidant, anti-inflammatory, and anticancer effects. This study investigates the protective effect of ethanolic extract (EE) and aqueous fraction (AF) fromPerilla fru

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35

Fang, Hu Biao, Lei Jin, Wei Chen Zai, Yu Rong Song, Jun Zhi Wang, and Nian Yu Huang. "Synthesis and H⁺/K⁺-ATPase Inhibitory Activity of 2-Phenyl-6,7-Dihydrobenzofuran-4(5H)-one Oxime Ether Derivatives." Advanced Materials Research 634-638 (January 2013): 1192–95. http://dx.doi.org/10.4028/www.scientific.net/amr.634-638.1192.

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Three pairs of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime and corresponding oxime ether isomers were synthesized and separated as potential anti-ulcer agent. Their structures were characterized by NMR, IR, ESI-MS and elemental analysis. Preliminarily H+/K+-ATPase activity evaluation indicated that all the target compounds had a better inhibitory effect than the commercial omeprazole with the IC50 of 2.0~30.0 μM.

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36

Martín, M. J., C. La -Casa, C. Alarcón-de-la-Lastra, J. Cabeza, I. Villegas, and V. Motilva. "Anti-Oxidant Mechanisms Involved in Gastroprotective Effects of Quercetin." Zeitschrift für Naturforschung C 53, no. 1-2 (1998): 82–88. http://dx.doi.org/10.1515/znc-1998-1-215.

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Abstract The anti-ulcerogenic and anti-oxidant effects of various flavonoids have been frequently reported. We investigated the cytoprotective properties of quercetin, a natural flavone, in gastric mucosal injury induced by 50% ethanol, since in this experimental model the pathogenesis of the lesions has been related with production of reactive oxygen species. The involvement of neutrophil infiltration and the capacity of this flavonoid to restrain the oxidative process produced in the gastric tissue after ethanol administration were also investigated. Oral pretreatment with the highest dos

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37

Molina, F., MM Vohra, and CN Williams. "Pharmacotherapy of Peptic Ulcer Disease." Canadian Journal of Gastroenterology 5, no. 1 (1991): 21–33. http://dx.doi.org/10.1155/1991/683517.

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The etiology of peptic ulcer is multifactorial; except for omeprazole, all drugs used for the treatment of peptic ulcer result in healing with no statistical difference at four weeks. The healing rare increases with time for active medication and placebo, and is lower among smokers than nonsmokers for all drugs but misoprostol. Mucosal protectives (or ‘cytoprotectives’) as a group seem to have a lower relapse rate than the H2receptor antagonists at one year. Combination therapy has not yet proved to be better than single drug therapy; however, the number of studies is still small, and more cli

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38

Diaz, Diana, Heinz Döbeli, Dorothy Yeboah-Manu, et al. "Use of the Immunodominant 18-Kilodalton Small Heat Shock Protein as a Serological Marker for Exposure to Mycobacterium ulcerans." Clinical and Vaccine Immunology 13, no. 12 (2006): 1314–21. http://dx.doi.org/10.1128/cvi.00254-06.

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ABSTRACT While it is well established that proximity to wetlands is a risk factor for contracting Buruli ulcer, it is not clear what proportion of a population living in an area where the etiologic agent, Mycobacterium ulcerans, is endemic is actually exposed to this disease. Immunological cross-reactivity among mycobacterial species complicates the development of a specific serological test. Among immunodominant proteins recognized by a panel of anti-M. ulcerans monoclonal antibodies, the M. ulcerans homologue of the M. leprae 18-kDa small heat shock protein (shsp) was identified. Since this

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39

Wang, Cuizhu, Yuze Yuan, He Pan, et al. "Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics." International Journal of Molecular Sciences 21, no. 7 (2020): 2577. http://dx.doi.org/10.3390/ijms21072577.

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Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric m

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40

TOYAMA, Seiji, Takeshi ITABASHI, Junko NAKAYA, Tohru SUGIMOTO, Masahiro MIWA, and Hiroshi SANO. "Effect of Polaprezinc, a Novel Anti-ulcer Agent, On the Gastrointestinal Absorption of Antibiotics in Dogs." Drug Metabolism and Pharmacokinetics 11, no. 1 (1996): 38–44. http://dx.doi.org/10.2133/dmpk.11.38.

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41

Yamazaki, Satoshi, Makoto Kawamura, and Akihiro Tobe. "Effects of MCI-727, a new anti-ulcer agent, on gastric mucosal prostaglandin level in rats." Japanese Journal of Pharmacology 58 (1992): 351. http://dx.doi.org/10.1016/s0021-5198(19)49546-2.

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42

Sakurai, Kazushi, and Katsuya Yamasaki. "A novel anti-ulcer agent, rebamipide attenuates reactive oxygen metabolites by two different mechanisms in vitro." Japanese Journal of Pharmacology 64 (1994): 285. http://dx.doi.org/10.1016/s0021-5198(19)50772-7.

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43

Shimoyama, Tadashi, Shinsaku Fukuda, Qiang Liu, Yoshihiro Fukuda, Shigeyuki Nakaji, and Kazuo Sugawara. "Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils." Journal of Pharmacological Sciences 91, no. 2 (2003): 153–57. http://dx.doi.org/10.1254/jphs.91.153.

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44

Cao, Tingting, Yong Li, Ziyao Yang, et al. "Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent." Chemical Biology & Drug Design 88, no. 2 (2016): 264–71. http://dx.doi.org/10.1111/cbdd.12753.

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45

Belhocine, Mansouria, Abdelkader Homrani, Fatima Azzouz Azzouz, and Chahrazed Sakmeche. "Gastro-protective effects of camel milk on indomethacin-induced peptic ulcer in Wistar rats." South Asian Journal of Experimental Biology 7, no. 2 (2018): 42–56. http://dx.doi.org/10.38150/sajeb.7(2).p42-56.

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Gastric ulcer associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin is a major public health problem. The present study was undertaken to determine the camel milk antioxidant activity, tested on DPPH, and its gastro-protective effect, investigated in Wistar rats sub-jected to gastric ulcer induced by a nonsteroidal anti-inflammatory agent, indomethacin. The study was performed on 20 adult male Wistar rats divided into 4 groups of 5 rats each. The negative control group received distilled water, the positive control group received indomethacin, the standa

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46

Pachevska, Alisa V., Alina V. Biloshitska, and Valery M. Istoshyn. "Effects of Prophylactic Use of a Decoction of Blueberry Leaves in Modeling the Lesion of the Gastrointestinal Tract by Non-Steroidal Anti-Inflammatory Drugs." Acta Balneologica 62, no. 4 (2020): 239–44. http://dx.doi.org/10.36740/abal202004107.

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Introduction: Today there is a continuing search for an effective, affordable remedy that can be used to treat and prevent diseases of periodontal, stomach and duodenum during the use non-steroidal anti-inflammatory drugs ( NSAIDs ). Aim: To study the protective effect of phytopreparation (decoction of blueberry leaves) on an experimental model of gastric ulcer and periodontitis. Material and Methods: The study was performed on 30 rats, which were evenly divided into three groups: 1 – control animals, 2 – animals that were modeled with non-steroid gastric ulcer and periodontitis (7 mg/kg diclo

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47

Chatterjee, Ananya, Subrata Chattopadhyay, and Sandip K. Bandyopadhyay. "Biphasic Effect ofPhyllanthus emblicaL. Extract on NSAID-Induced Ulcer: An Antioxidative Trail Weaved with Immunomodulatory Effect." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/146808.

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Amla (Phyllanthus emblicaL.), apart from its food value, can be used as a gastroprotective agent in non steroidal anti-inflammatory drug (NSAID)-induced gastropathy. It has been suggested that the antioxidative property of amla is the key to its therapeutic effect. Hence, on the basis ofin vitroantioxidative potential, the ethanolic extract of amla (eAE) was selected forin vivostudy in NSAID-induced ulcer. Intriguingly, eAE showed biphasic activity in ulcerated mice, with healing effect observed at 60 mg/kg and an adverse effect at 120 mg/kg.The dose-dependent study revealed that switching fro

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48

YAMADA, Haruyoshi, Shingo TAJIMA, and Takeji NISHIKAWA. "Effect of an Anti-Gastric Ulcer Agent, Plaunotol(Kelnac), on Collagen Synthesis in Cultured Human Skin Fibroblasts." Nishi Nihon Hifuka 59, no. 5 (1997): 731–33. http://dx.doi.org/10.2336/nishinihonhifu.59.731.

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Asano, Masahide, Youichi Kurebayashi, Yuichi Ryokawa, et al. "Effects of DQ-2511, a new anti-ulcer agent, on experimental gastric and duodenal ulcers in rats." Japanese Journal of Pharmacology 40 (1986): 225. http://dx.doi.org/10.1016/s0021-5198(19)59422-7.

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Nozaki, Shinichi, Mitsuaki Maeda, Hiroyuki Tsuda, and George W. Sledge. "Inhibition of Breast Cancer Regrowth and Pulmonary Metastasis in Nude Mice by Anti-gastric Ulcer Agent, Irsogladine." Breast Cancer Research and Treatment 83, no. 3 (2004): 195–99. http://dx.doi.org/10.1023/b:brea.0000013996.49528.d8.

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